
                                SEQUENCE LISTING

<110> Zycos Inc.

<120> TRANSLATIONAL PROFILING
  

<130> 08191-026WO1

<150> 60/279,495          
<151> 2001-03-28  

<150> 60/292,544          
<151> 2001-05-21  

<150> 60/310,801          
<151> 2001-08-08  

<150> 60/326,370          
<151> 2001-10-01  

<150> 60/336,780          
<151> 2001-12-04  

<150> 60/358,985          
<151> 2002-02-20  

<160> 2041

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1
Val Ser Asp Lys Gly Asn Leu Met Tyr
 1               5

<210> 2
<211> 9
<212> PRT
<213> Homo sapiens

<400> 2
Val Ala Asp Lys Val His Leu Met Tyr
 1               5

<210> 3
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3
Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala Tyr Val
 1               5                  10

<210> 4
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4
Gly Pro Ala Leu Gly Arg Ser Phe Leu
 1               5

<210> 5
<211> 9
<212> PRT
<213> Homo sapiens

<400> 5
Lys Pro Ser Leu Pro Phe Thr Ser Leu
 1               5

<210> 6
<211> 10
<212> PRT
<213> Homo sapiens

<400> 6
Asp Val Ser Ile Gly Ala Phe Gly Gln Val
 1               5                  10

<210> 7
<211> 8
<212> PRT
<213> Homo sapiens

<400> 7
Leu Ser Asp Leu Glu Gln Gln Tyr
 1               5

<210> 8
<211> 9
<212> PRT
<213> Homo sapiens

<400> 8
Ser Leu Ala Glu Leu Val His Ala Val
 1               5

<210> 9
<211> 9
<212> PRT
<213> Homo sapiens

<400> 9
Ala Leu Thr Glu Leu Leu Ala Lys Ile
 1               5

<210> 10
<211> 9
<212> PRT
<213> Homo sapiens

<400> 10
Ile Leu Ser Glu Val Gln Gln Ala Val
 1               5

<210> 11
<211> 9
<212> PRT
<213> Homo sapiens

<400> 11
Lys Leu Val Lys Glu Val Ile Ala Val
 1               5

<210> 12
<211> 9
<212> PRT
<213> Homo sapiens

<400> 12
Leu Leu Asp His Ala Pro Pro Glu Ile
 1               5

<210> 13
<211> 9
<212> PRT
<213> Homo sapiens

<400> 13
Gly Leu Ile Glu Ile Leu Lys Lys Val
 1               5

<210> 14
<211> 9
<212> PRT
<213> Homo sapiens

<400> 14
Ala Leu Leu Asp Gln Leu His Thr Leu
 1               5

<210> 15
<211> 9
<212> PRT
<213> Homo sapiens

<400> 15
Thr Leu Ala Asp Val Leu Tyr His Val
 1               5

<210> 16
<211> 9
<212> PRT
<213> Homo sapiens

<400> 16
Val Leu Phe His Asn Leu Pro Ser Leu
 1               5

<210> 17
<211> 9
<212> PRT
<213> Homo sapiens

<400> 17
Val Leu Ala Asp Gln Glu Val Arg Leu
 1               5

<210> 18
<211> 10
<212> PRT
<213> Homo sapiens

<400> 18
Lys Val Phe Asp Pro Val Pro Val Gly Val
 1               5                  10

<210> 19
<211> 9
<212> PRT
<213> Homo sapiens

<400> 19
His Leu Leu Glu Gln Leu Ala Lys Leu
 1               5

<210> 20
<211> 9
<212> PRT
<213> Homo sapiens

<400> 20
Thr Leu Val Asp Glu Val Phe Arg Ile
 1               5

<210> 21
<211> 9
<212> PRT
<213> Homo sapiens

<400> 21
Ile Leu Gln Asp Arg Leu Asn Gln Val
 1               5

<210> 22
<211> 9
<212> PRT
<213> Homo sapiens

<400> 22
Lys Leu Met Asp Lys Val Val Arg Leu
 1               5

<210> 23
<211> 9
<212> PRT
<213> Homo sapiens

<400> 23
Leu Leu Gln Glu Val Glu His Gln Leu
 1               5

<210> 24
<211> 9
<212> PRT
<213> Homo sapiens

<400> 24
Trp Leu Val Asp His Val Tyr Ala Ile
 1               5

<210> 25
<211> 9
<212> PRT
<213> Homo sapiens

<400> 25
Tyr Leu Leu Thr Arg Asn Pro His Leu
 1               5

<210> 26
<211> 9
<212> PRT
<213> Homo sapiens

<400> 26
Ser Leu Leu Asp Glu Phe Tyr Lys Leu
 1               5

<210> 27
<211> 9
<212> PRT
<213> Homo sapiens

<400> 27
Lys Leu Phe Asp Thr Gln Gln Phe Leu
 1               5

<210> 28
<211> 11
<212> PRT
<213> Homo sapiens

<400> 28
Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
 1               5                  10

<210> 29
<211> 10
<212> PRT
<213> Homo sapiens

<400> 29
Lys Leu Met Asp Leu Asp Val Glu Gln Leu
 1               5                  10

<210> 30
<211> 11
<212> PRT
<213> Homo sapiens

<400> 30
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu
 1               5                  10

<210> 31
<211> 11
<212> PRT
<213> Homo sapiens

<400> 31
Tyr Gln Phe Asp Lys Val Gly Ile Leu Thr Leu
 1               5                  10

<210> 32
<211> 11
<212> PRT
<213> Homo sapiens

<400> 32
Ile Leu Leu Asp Glu Arg Gly Gln Ile Lys Leu
 1               5                  10

<210> 33
<211> 12
<212> PRT
<213> Homo sapiens

<400> 33
Lys Leu Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala
 1               5                  10

<210> 34
<211> 13
<212> PRT
<213> Homo sapiens

<400> 34
Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly Tyr Lys Leu
 1               5                  10

<210> 35
<211> 9
<212> PRT
<213> Homo sapiens

<400> 35
Tyr Leu Ser Pro Asp Leu Ser Lys Val
 1               5

<210> 36
<211> 10
<212> PRT
<213> Homo sapiens

<400> 36
Ile Leu Gln Ser Thr Arg Leu Pro Leu Ile
 1               5                  10

<210> 37
<211> 9
<212> PRT
<213> Homo sapiens

<400> 37
Phe Leu Asp Lys Gln Gly Phe Tyr Val
 1               5

<210> 38
<211> 9
<212> PRT
<213> Homo sapiens

<400> 38
Ala Leu Asn Glu Gln Ile Ala Arg Leu
 1               5

<210> 39
<211> 9
<212> PRT
<213> Homo sapiens

<400> 39
Ser Leu Leu Gln Thr Gln His Ala Leu
 1               5

<210> 40
<211> 10
<212> PRT
<213> Homo sapiens

<400> 40
Ile Ala Pro Ala Leu Val Ser Lys Lys Leu
 1               5                  10

<210> 41
<211> 9
<212> PRT
<213> Homo sapiens

<400> 41
Ala Leu Leu Val Arg Leu Gln Glu Val
 1               5

<210> 42
<211> 9
<212> PRT
<213> Homo sapiens

<400> 42
Asn Met Val Asp Ile Ile His Ser Val
 1               5

<210> 43
<211> 9
<212> PRT
<213> Homo sapiens

<400> 43
Leu Leu Ala Glu Lys Ile Tyr Lys Ile
 1               5

<210> 44
<211> 9
<212> PRT
<213> Homo sapiens

<400> 44
Leu Ser Ser Val Lys Asp Arg Phe Ile
 1               5

<210> 45
<211> 9
<212> PRT
<213> Homo sapiens

<400> 45
Val Leu Phe Ser Phe Ile Val Ser Val
 1               5

<210> 46
<211> 9
<212> PRT
<213> Homo sapiens

<400> 46
Arg Leu Phe His Leu His Ser Gln Lys
 1               5

<210> 47
<211> 9
<212> PRT
<213> Homo sapiens

<400> 47
Ala Val Gln Arg Thr Leu Leu Glu Lys
 1               5

<210> 48
<211> 10
<212> PRT
<213> Homo sapiens

<400> 48
Ala Gln Asn Ser Val Ile Ile Val Asp Lys
 1               5                  10

<210> 49
<211> 10
<212> PRT
<213> Homo sapiens

<400> 49
Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg
 1               5                  10

<210> 50
<211> 9
<212> PRT
<213> Homo sapiens

<400> 50
Ser Pro Ala Ser Arg Ser Ile Ser Leu
 1               5

<210> 51
<211> 9
<212> PRT
<213> Homo sapiens

<400> 51
Ala Pro Gln Asn His Thr Ile Ser Leu
 1               5

<210> 52
<211> 9
<212> PRT
<213> Homo sapiens

<400> 52
Ala Pro Ala Arg Leu Leu Ala Pro Leu
 1               5

<210> 53
<211> 9
<212> PRT
<213> Homo sapiens

<400> 53
Ser Pro Gln Lys Val Thr Leu Tyr Leu
 1               5

<210> 54
<211> 10
<212> PRT
<213> Homo sapiens

<400> 54
Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro
 1               5                  10

<210> 55
<211> 9
<212> PRT
<213> Homo sapiens

<400> 55
Lys Pro Arg Asp Gln Val Val Ala Leu
 1               5

<210> 56
<211> 9
<212> PRT
<213> Homo sapiens

<400> 56
Ser Pro Val Phe Arg Leu Glu Thr Leu
 1               5

<210> 57
<211> 16
<212> PRT
<213> Homo sapiens

<400> 57
Ala Pro Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu
 1               5                  10                  15

<210> 58
<211> 19
<212> PRT
<213> Homo sapiens

<400> 58
Ile Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser
 1               5                  10                  15
Asn Arg Ile


<210> 59
<211> 20
<212> PRT
<213> Homo sapiens

<400> 59
Ile Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser
 1               5                  10                  15
Asn Arg Ile Tyr
            20

<210> 60
<211> 17
<212> PRT
<213> Homo sapiens

<400> 60
Asn Asp His Val Leu Leu Phe Trp Lys Ser Leu Ala Leu Lys Glu Lys
 1               5                  10                  15
His


<210> 61
<211> 15
<212> PRT
<213> Homo sapiens

<400> 61
His Leu Lys Ala Phe Thr Tyr Ile Asn Leu Asp Lys Ala Val Leu
 1               5                  10                  15

<210> 62
<211> 18
<212> PRT
<213> Homo sapiens

<400> 62
Ile Pro Val Gln Thr Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly
 1               5                  10                  15
Asn Met


<210> 63
<211> 13
<212> PRT
<213> Homo sapiens

<400> 63
Lys Ala Phe Thr Tyr Ile Asn Leu Asp Lys Ala Val Leu
 1               5                  10

<210> 64
<211> 19
<212> PRT
<213> Homo sapiens

<400> 64
Pro Asn Ile Pro Val Gln Thr Ile Ser Arg Ala Ala Ala Glu Lys Leu
 1               5                  10                  15
Phe Gly Asn


<210> 65
<211> 17
<212> PRT
<213> Homo sapiens

<400> 65
Val Met Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln
 1               5                  10                  15
Lys


<210> 66
<211> 15
<212> PRT
<213> Homo sapiens

<400> 66
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val
 1               5                  10                  15

<210> 67
<211> 20
<212> PRT
<213> Homo sapiens

<400> 67
Gly Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr
 1               5                  10                  15
Asp Lys Pro His
            20

<210> 68
<211> 21
<212> PRT
<213> Homo sapiens

<400> 68
Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala
 1               5                  10                  15
Leu His Glu Asp Ile
            20

<210> 69
<211> 18
<212> PRT
<213> Homo sapiens

<400> 69
Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly
 1               5                  10                  15
Gly Asp


<210> 70
<211> 14
<212> PRT
<213> Homo sapiens

<400> 70
His Thr Gly Ser Trp Ile Gly Leu Arg Asn Leu Asp Leu Lys
 1               5                  10

<210> 71
<211> 15
<212> PRT
<213> Homo sapiens

<400> 71
His Thr Gly Ser Trp Ile Gly Leu Arg Asn Leu Asp Leu Lys Gly
 1               5                  10                  15

<210> 72
<211> 16
<212> PRT
<213> Homo sapiens

<400> 72
His Thr Gly Ser Trp Ile Gly Leu Arg Asn Leu Asp Leu Lys Gly Glu
 1               5                  10                  15

<210> 73
<211> 13
<212> PRT
<213> Homo sapiens

<400> 73
Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val Asp
 1               5                  10

<210> 74
<211> 18
<212> PRT
<213> Homo sapiens

<400> 74
Ser His Thr Gly Ser Trp Ile Gly Leu Arg Asn Leu Asp Leu Lys Gly
 1               5                  10                  15
Glu Phe


<210> 75
<211> 15
<212> PRT
<213> Homo sapiens

<400> 75
Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn
 1               5                  10                  15

<210> 76
<211> 14
<212> PRT
<213> Homo sapiens

<400> 76
Arg Thr Gly Thr Phe Ile Ala Leu Ser Asn Ile Leu Glu Arg
 1               5                  10

<210> 77
<211> 18
<212> PRT
<213> Homo sapiens

<400> 77
His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp Ala Ser
 1               5                  10                  15
Lys Val


<210> 78
<211> 16
<212> PRT
<213> Homo sapiens

<400> 78
Ile Pro Val Gln Thr Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly
 1               5                  10                  15

<210> 79
<211> 15
<212> PRT
<213> Homo sapiens

<400> 79
Met Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Lys
 1               5                  10                  15

<210> 80
<211> 16
<212> PRT
<213> Homo sapiens

<400> 80
Met Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Lys Glu
 1               5                  10                  15

<210> 81
<211> 19
<212> PRT
<213> Homo sapiens

<400> 81
Met Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Lys Glu
 1               5                  10                  15
Ser Pro Phe


<210> 82
<211> 14
<212> PRT
<213> Homo sapiens

<400> 82
Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Lys
 1               5                  10

<210> 83
<211> 16
<212> PRT
<213> Homo sapiens

<400> 83
Val Met Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Lys
 1               5                  10                  15

<210> 84
<211> 17
<212> PRT
<213> Homo sapiens

<400> 84
Val Met Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Lys
 1               5                  10                  15
Glu


<210> 85
<211> 11
<212> PRT
<213> Homo sapiens

<400> 85
Val Val Phe Asp Thr Ser Leu Gln Val Lys Lys
 1               5                  10

<210> 86
<211> 11
<212> PRT
<213> Homo sapiens

<400> 86
Gln Val Asp Ile Ser Glu Glu Ala Thr Leu Glu
 1               5                  10

<210> 87
<211> 10
<212> PRT
<213> Homo sapiens

<400> 87
Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu
 1               5                  10

<210> 88
<211> 14
<212> PRT
<213> Homo sapiens

<400> 88
Ala Lys Leu Ile Ala Thr Phe Pro Asp Thr Leu Thr Tyr Ser
 1               5                  10

<210> 89
<211> 15
<212> PRT
<213> Homo sapiens

<400> 89
Val Leu Lys Gly Ile Ser Pro Tyr Phe Gly Tyr Ser Ile Ala Gly
 1               5                  10                  15

<210> 90
<211> 6
<212> PRT
<213> Homo sapiens

<400> 90
Asn Leu Ser Asn Phe Leu
 1               5

<210> 91
<211> 18
<212> PRT
<213> Homo sapiens

<400> 91
Asn Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg
 1               5                  10                  15
Ala Gly


<210> 92
<211> 16
<212> PRT
<213> Homo sapiens

<400> 92
Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro
 1               5                  10                  15

<210> 93
<211> 14
<212> PRT
<213> Homo sapiens

<400> 93
Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly Met Val Ile
 1               5                  10

<210> 94
<211> 13
<212> PRT
<213> Homo sapiens

<400> 94
Lys Pro Arg Ala Ile Val Val Asp Pro Val His Gly Phe
 1               5                  10

<210> 95
<211> 11
<212> PRT
<213> Homo sapiens

<400> 95
Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu
 1               5                  10

<210> 96
<211> 10
<212> PRT
<213> Homo sapiens

<400> 96
Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
 1               5                  10

<210> 97
<211> 9
<212> PRT
<213> Homo sapiens

<400> 97
Tyr Gln Phe Ser Lys Asn Phe Ser Leu
 1               5

<210> 98
<211> 9
<212> PRT
<213> Homo sapiens

<400> 98
Phe Leu Val Thr Val Ile His Thr Leu
 1               5

<210> 99
<211> 9
<212> PRT
<213> Homo sapiens

<400> 99
Ile Leu Lys Lys Val Leu Glu Ala Leu
 1               5

<210> 100
<211> 9
<212> PRT
<213> Homo sapiens

<400> 100
Ile Ile Ile Pro Glu Ile Gln Lys Val
 1               5

<210> 101
<211> 9
<212> PRT
<213> Homo sapiens

<400> 101
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 102
<211> 9
<212> PRT
<213> Homo sapiens

<400> 102
Lys Ile Leu Pro Thr Leu Glu Ala Val
 1               5

<210> 103
<211> 9
<212> PRT
<213> Homo sapiens

<400> 103
Asn Ile Asp Glu Ile Tyr Lys Ala Leu
 1               5

<210> 104
<211> 9
<212> PRT
<213> Homo sapiens

<400> 104
Lys Phe Leu Glu Lys Leu Gln Thr Leu
 1               5

<210> 105
<211> 10
<212> PRT
<213> Homo sapiens

<400> 105
Gly Met Lys Asp Gly Gln Lys Ile Thr Phe
 1               5                  10

<210> 106
<211> 9
<212> PRT
<213> Homo sapiens

<400> 106
Ile Thr Leu Lys Ala Phe Asn Asn Val
 1               5

<210> 107
<211> 9
<212> PRT
<213> Homo sapiens

<400> 107
Lys Leu Asp Arg Leu Leu Leu Glu Leu
 1               5

<210> 108
<211> 10
<212> PRT
<213> Homo sapiens

<400> 108
Val Leu Tyr Gly Pro Asp Val Pro Thr Ile
 1               5                  10

<210> 109
<211> 9
<212> PRT
<213> Homo sapiens

<400> 109
Lys Leu Asp His Val Val Thr Ile Ile
 1               5

<210> 110
<211> 10
<212> PRT
<213> Homo sapiens

<400> 110
Ile Leu Asp Asp Val Ser Leu Thr His Leu
 1               5                  10

<210> 111
<211> 12
<212> PRT
<213> Homo sapiens

<400> 111
Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg
 1               5                  10

<210> 112
<211> 13
<212> PRT
<213> Homo sapiens

<400> 112
Phe Ala Ala Ala Thr Gly Ala Thr Pro Ile Ala Gly Arg
 1               5                  10

<210> 113
<211> 13
<212> PRT
<213> Homo sapiens

<400> 113
Gln Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys
 1               5                  10

<210> 114
<211> 11
<212> PRT
<213> Homo sapiens

<400> 114
Ile Gln Val Leu Val Glu Pro Asp His Phe Lys
 1               5                  10

<210> 115
<211> 9
<212> PRT
<213> Homo sapiens

<400> 115
Phe Gln Asp Ser Val Phe Asn Asp Leu
 1               5

<210> 116
<211> 10
<212> PRT
<213> Homo sapiens

<400> 116
Gly Leu Ile Ser Gly Ile Ser Ile Ile Val
 1               5                  10

<210> 117
<211> 9
<212> PRT
<213> Homo sapiens

<400> 117
Gln Leu Asp Ser Val Arg Val Trp Leu
 1               5

<210> 118
<211> 9
<212> PRT
<213> Homo sapiens

<400> 118
Tyr Val Asp Pro Val Asn Lys Val Leu
 1               5

<210> 119
<211> 9
<212> PRT
<213> Homo sapiens

<400> 119
Met Leu Pro Lys Asp Ile Ala Lys Leu
 1               5

<210> 120
<211> 9
<212> PRT
<213> Homo sapiens

<400> 120
Val Leu Trp Asp Arg Thr Phe Ser Leu
 1               5

<210> 121
<211> 8
<212> PRT
<213> Homo sapiens

<400> 121
Ser Leu Asp Arg Tyr Ile Lys Ile
 1               5

<210> 122
<211> 9
<212> PRT
<213> Homo sapiens

<400> 122
Thr Leu Ile Pro Ala Met Ala Phe Leu
 1               5

<210> 123
<211> 17
<212> PRT
<213> Homo sapiens

<400> 123
Ala Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser
 1               5                  10                  15
Arg


<210> 124
<211> 11
<212> PRT
<213> Homo sapiens

<400> 124
Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg
 1               5                  10

<210> 125
<211> 10
<212> PRT
<213> Homo sapiens

<400> 125
Val Ala Leu Ala Gly Val Ala Gly Leu Leu
 1               5                  10

<210> 126
<211> 10
<212> PRT
<213> Homo sapiens

<400> 126
Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu
 1               5                  10

<210> 127
<211> 9
<212> PRT
<213> Homo sapiens

<400> 127
Ile Met Ile Gly Val Leu Val Gly Val
 1               5

<210> 128
<211> 17
<212> PRT
<213> Homo sapiens

<400> 128
Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys Ala Ala Thr Val Thr Gly
 1               5                  10                  15
Lys


<210> 129
<211> 15
<212> PRT
<213> Homo sapiens

<400> 129
Lys Ser Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln
 1               5                  10                  15

<210> 130
<211> 14
<212> PRT
<213> Homo sapiens

<400> 130
Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys
 1               5                  10

<210> 131
<211> 18
<212> PRT
<213> Homo sapiens

<400> 131
Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser
 1               5                  10                  15
Pro Ser


<210> 132
<211> 15
<212> PRT
<213> Homo sapiens

<400> 132
Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
 1               5                  10                  15

<210> 133
<211> 14
<212> PRT
<213> Homo sapiens

<400> 133
Tyr Val Ala Tyr Ser Lys Ala Ala Thr Val Thr Gly Lys Leu
 1               5                  10

<210> 134
<211> 9
<212> PRT
<213> Homo sapiens

<400> 134
Ala Met Ser Ser Lys Phe Phe Leu Val
 1               5

<210> 135
<211> 9
<212> PRT
<213> Homo sapiens

<400> 135
Met Val Asn Pro Val Ile Tyr Ala Leu
 1               5

<210> 136
<211> 9
<212> PRT
<213> Homo sapiens

<400> 136
Gly Leu Tyr Ser Gly Val Thr Thr Val
 1               5

<210> 137
<211> 11
<212> PRT
<213> Homo sapiens

<400> 137
Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val
 1               5                  10

<210> 138
<211> 9
<212> PRT
<213> Homo sapiens

<400> 138
Lys Leu Gln Glu Leu Asn Tyr Asn Leu
 1               5

<210> 139
<211> 9
<212> PRT
<213> Homo sapiens

<400> 139
Lys Leu Leu Gly Glu Leu His Thr Leu
 1               5

<210> 140
<211> 9
<212> PRT
<213> Homo sapiens

<400> 140
Ala Val Leu Glu Leu Lys Asn Glu Leu
 1               5

<210> 141
<211> 9
<212> PRT
<213> Homo sapiens

<400> 141
Ala Thr Ile Gln Gly Ala Tyr Ala Arg
 1               5

<210> 142
<211> 9
<212> PRT
<213> Homo sapiens

<400> 142
Val Ile Leu Asp Lys Tyr Tyr Phe Leu
 1               5

<210> 143
<211> 18
<212> PRT
<213> Homo sapiens

<400> 143
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
 1               5                  10                  15
Ser Arg


<210> 144
<211> 10
<212> PRT
<213> Homo sapiens

<400> 144
Val Ile Asp Glu Val Arg Thr Gly Thr Tyr
 1               5                  10

<210> 145
<211> 9
<212> PRT
<213> Homo sapiens

<400> 145
Ser Leu Ser Asp His Ile Val Leu Leu
 1               5

<210> 146
<211> 9
<212> PRT
<213> Homo sapiens

<400> 146
Arg Leu Ala Val Tyr Ile Asp Arg Val
 1               5

<210> 147
<211> 10
<212> PRT
<213> Homo sapiens

<400> 147
Leu Leu Tyr Gln Gly Pro His Asn Thr Leu
 1               5                  10

<210> 148
<211> 9
<212> PRT
<213> Homo sapiens

<400> 148
Leu Leu Ser Ala Glu Pro Val Pro Ala
 1               5

<210> 149
<211> 9
<212> PRT
<213> Homo sapiens

<400> 149
Ser Met Ser Ala Asp Val Pro Leu Val
 1               5

<210> 150
<211> 9
<212> PRT
<213> Homo sapiens

<400> 150
Thr Val Leu Pro Phe Val Ser Thr Val
 1               5

<210> 151
<211> 18
<212> PRT
<213> Homo sapiens

<400> 151
Glu Gly Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu
 1               5                  10                  15
Phe Gly


<210> 152
<211> 14
<212> PRT
<213> Homo sapiens

<400> 152
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu
 1               5                  10

<210> 153
<211> 13
<212> PRT
<213> Homo sapiens

<400> 153
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His
 1               5                  10

<210> 154
<211> 15
<212> PRT
<213> Homo sapiens

<400> 154
Gly Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu
 1               5                  10                  15

<210> 155
<211> 16
<212> PRT
<213> Homo sapiens

<400> 155
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
 1               5                  10                  15

<210> 156
<211> 15
<212> PRT
<213> Homo sapiens

<400> 156
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe
 1               5                  10                  15

<210> 157
<211> 16
<212> PRT
<213> Homo sapiens

<400> 157
Glu Gly Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu
 1               5                  10                  15

<210> 158
<211> 18
<212> PRT
<213> Homo sapiens

<400> 158
Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln
 1               5                  10                  15
His Thr


<210> 159
<211> 17
<212> PRT
<213> Homo sapiens

<400> 159
Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln
 1               5                  10                  15
His


<210> 160
<211> 15
<212> PRT
<213> Homo sapiens

<400> 160
Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg
 1               5                  10                  15

<210> 161
<211> 8
<212> PRT
<213> Homo sapiens

<400> 161
Leu Leu Val Val Thr Asp Pro Arg
 1               5

<210> 162
<211> 9
<212> PRT
<213> Homo sapiens

<400> 162
Phe Phe Val Ser Ser Ser Gln Gly Arg
 1               5

<210> 163
<211> 10
<212> PRT
<213> Homo sapiens

<400> 163
Leu Leu Pro Gly Leu Asp Leu Asn His Lys
 1               5                  10

<210> 164
<211> 10
<212> PRT
<213> Homo sapiens

<400> 164
Ser Asp Gly Ile Tyr Ile Ile Asn Leu Lys
 1               5                  10

<210> 165
<211> 10
<212> PRT
<213> Homo sapiens

<400> 165
Lys Asp Val Leu Glu Thr Phe Thr Val Lys
 1               5                  10

<210> 166
<211> 11
<212> PRT
<213> Homo sapiens

<400> 166
Ser Asp Gly Ile Tyr Ile Ile Asn Leu Lys Arg
 1               5                  10

<210> 167
<211> 15
<212> PRT
<213> Homo sapiens

<400> 167
Lys Phe Tyr Gly Pro Glu Gly Pro Tyr Gly Val Phe Ala Gly Arg
 1               5                  10                  15

<210> 168
<211> 11
<212> PRT
<213> Homo sapiens

<400> 168
Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val
 1               5                  10

<210> 169
<211> 9
<212> PRT
<213> Homo sapiens

<400> 169
Lys Leu Asp Lys Gln Tyr Glu Ser Leu
 1               5

<210> 170
<211> 9
<212> PRT
<213> Homo sapiens

<400> 170
Leu Val His Ala Asn Phe Gly Thr Lys
 1               5

<210> 171
<211> 11
<212> PRT
<213> Homo sapiens

<400> 171
Gly His Gln Ala Phe Asp Val Gly Gln Pro Arg
 1               5                  10

<210> 172
<211> 11
<212> PRT
<213> Homo sapiens

<400> 172
Tyr Val Asp Ile Ala Ile Pro Cys Asn Asn Lys
 1               5                  10

<210> 173
<211> 11
<212> PRT
<213> Homo sapiens

<400> 173
Lys Ser Asp Gly Ile Tyr Ile Ile Asn Leu Lys
 1               5                  10

<210> 174
<211> 15
<212> PRT
<213> Homo sapiens

<400> 174
Asp Pro Glu Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys
 1               5                  10                  15

<210> 175
<211> 8
<212> PRT
<213> Homo sapiens

<400> 175
Leu Leu Pro Pro Val Phe Asn Ile
 1               5

<210> 176
<211> 9
<212> PRT
<213> Homo sapiens

<400> 176
Ser Leu Pro Glu Val Leu Pro Ile Leu
 1               5

<210> 177
<211> 9
<212> PRT
<213> Homo sapiens

<400> 177
Tyr Gly Leu Pro Val Val Val Lys Leu
 1               5

<210> 178
<211> 9
<212> PRT
<213> Homo sapiens

<400> 178
Ala Leu Pro Val Phe Phe Ile Leu Ala
 1               5

<210> 179
<211> 9
<212> PRT
<213> Homo sapiens

<400> 179
His Leu Asp Gly Val His Val Val Phe
 1               5

<210> 180
<211> 9
<212> PRT
<213> Homo sapiens

<400> 180
Ser Leu Asp Gln Ile Ile Gln His Leu
 1               5

<210> 181
<211> 10
<212> PRT
<213> Homo sapiens

<400> 181
Ile Val Glu Val Leu Glu Asp Val Pro Leu
 1               5                  10

<210> 182
<211> 9
<212> PRT
<213> Homo sapiens

<400> 182
Tyr Leu Asp Thr Leu Tyr Arg Tyr Ala
 1               5

<210> 183
<211> 11
<212> PRT
<213> Homo sapiens

<400> 183
Leu Leu His Gln Glu Gly Ala Lys Met Ala Val
 1               5                  10

<210> 184
<211> 11
<212> PRT
<213> Homo sapiens

<400> 184
Leu Leu Asp Asp Pro Ala Asn Ala His Phe Ile
 1               5                  10

<210> 185
<211> 9
<212> PRT
<213> Homo sapiens

<400> 185
Phe Gln Asp Asp Arg Tyr Leu Tyr Met
 1               5

<210> 186
<211> 9
<212> PRT
<213> Homo sapiens

<400> 186
Lys Thr Asp Lys Thr Leu Val Leu Leu
 1               5

<210> 187
<211> 10
<212> PRT
<213> Homo sapiens

<400> 187
Asn Leu Phe Gly Gly Glu Pro Leu Ser Tyr
 1               5                  10

<210> 188
<211> 9
<212> PRT
<213> Homo sapiens

<400> 188
Lys Gln Ile Asp Asp Asn Arg Lys Phe
 1               5

<210> 189
<211> 8
<212> PRT
<213> Homo sapiens

<400> 189
Lys Leu Val Gly Tyr Leu Asp Arg
 1               5

<210> 190
<211> 16
<212> PRT
<213> Homo sapiens

<400> 190
Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys
 1               5                  10                  15

<210> 191
<211> 16
<212> PRT
<213> Homo sapiens

<400> 191
Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys
 1               5                  10                  15

<210> 192
<211> 10
<212> PRT
<213> Homo sapiens

<400> 192
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
 1               5                  10

<210> 193
<211> 14
<212> PRT
<213> Homo sapiens

<400> 193
Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
 1               5                  10

<210> 194
<211> 17
<212> PRT
<213> Homo sapiens

<400> 194
Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn Ser Asp Glu Pro
 1               5                  10                  15
Lys


<210> 195
<211> 11
<212> PRT
<213> Homo sapiens

<400> 195
Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg
 1               5                  10

<210> 196
<211> 16
<212> PRT
<213> Homo sapiens

<400> 196
Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
 1               5                  10                  15

<210> 197
<211> 11
<212> PRT
<213> Homo sapiens

<400> 197
Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg
 1               5                  10

<210> 198
<211> 16
<212> PRT
<213> Homo sapiens

<400> 198
Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys
 1               5                  10                  15

<210> 199
<211> 11
<212> PRT
<213> Homo sapiens

<400> 199
Thr Gln His Ile Gly Asn Gln Glu Glu Asn Lys
 1               5                  10

<210> 200
<211> 9
<212> PRT
<213> Homo sapiens

<400> 200
Tyr Leu Ile Glu Leu Ile Asp Arg Val
 1               5

<210> 201
<211> 16
<212> PRT
<213> Homo sapiens

<400> 201
His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ser Arg
 1               5                  10                  15

<210> 202
<211> 10
<212> PRT
<213> Homo sapiens

<400> 202
Ser Phe Leu His Gly Pro Glu Leu Asp Lys
 1               5                  10

<210> 203
<211> 19
<212> PRT
<213> Homo sapiens

<400> 203
Ala His Thr Pro Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro
 1               5                  10                  15
Ser Glu Lys


<210> 204
<211> 12
<212> PRT
<213> Homo sapiens

<400> 204
His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
 1               5                  10

<210> 205
<211> 9
<212> PRT
<213> Homo sapiens

<400> 205
Gly Leu Val Leu Gly Pro Ile His Lys
 1               5

<210> 206
<211> 10
<212> PRT
<213> Homo sapiens

<400> 206
Leu Glu Pro His Glu Gly Leu Leu Leu Arg
 1               5                  10

<210> 207
<211> 14
<212> PRT
<213> Homo sapiens

<400> 207
Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys
 1               5                  10

<210> 208
<211> 10
<212> PRT
<213> Homo sapiens

<400> 208
Gly Glu Glu Asp Asn Ser Leu Ser Val Arg
 1               5                  10

<210> 209
<211> 14
<212> PRT
<213> Homo sapiens

<400> 209
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg
 1               5                  10

<210> 210
<211> 20
<212> PRT
<213> Homo sapiens

<400> 210
Asp Leu Leu Leu Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly
 1               5                  10                  15
Glu His Thr Lys
            20

<210> 211
<211> 13
<212> PRT
<213> Homo sapiens

<400> 211
Val Phe Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys
 1               5                  10

<210> 212
<211> 12
<212> PRT
<213> Homo sapiens

<400> 212
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg
 1               5                  10

<210> 213
<211> 12
<212> PRT
<213> Homo sapiens

<400> 213
Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg
 1               5                  10

<210> 214
<211> 14
<212> PRT
<213> Homo sapiens

<400> 214
Gly Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg
 1               5                  10

<210> 215
<211> 19
<212> PRT
<213> Homo sapiens

<400> 215
Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala
 1               5                  10                  15
Gly Leu Lys


<210> 216
<211> 14
<212> PRT
<213> Homo sapiens

<400> 216
Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
 1               5                  10

<210> 217
<211> 18
<212> PRT
<213> Homo sapiens

<400> 217
Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val His Leu
 1               5                  10                  15
Ile Lys


<210> 218
<211> 17
<212> PRT
<213> Homo sapiens

<400> 218
Gly Asp Cys Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val
 1               5                  10                  15
Lys


<210> 219
<211> 13
<212> PRT
<213> Homo sapiens

<400> 219
Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Lys
 1               5                  10

<210> 220
<211> 19
<212> PRT
<213> Homo sapiens

<400> 220
Ala Asp Phe Pro Thr Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser
 1               5                  10                  15
Asn Ile Arg


<210> 221
<211> 16
<212> PRT
<213> Homo sapiens

<400> 221
Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr Arg
 1               5                  10                  15

<210> 222
<211> 20
<212> PRT
<213> Homo sapiens

<400> 222
Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala
 1               5                  10                  15
Asn Asn Ala Lys
            20

<210> 223
<211> 16
<212> PRT
<213> Homo sapiens

<400> 223
Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr Val Ala Thr Lys
 1               5                  10                  15

<210> 224
<211> 15
<212> PRT
<213> Homo sapiens

<400> 224
Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala Glu Phe Gln Arg
 1               5                  10                  15

<210> 225
<211> 10
<212> PRT
<213> Homo sapiens

<400> 225
Ser Leu Leu His Gly Asp Phe His Ala Phe
 1               5                  10

<210> 226
<211> 18
<212> PRT
<213> Homo sapiens

<400> 226
Asp Asp Val Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly
 1               5                  10                  15
Ser Lys


<210> 227
<211> 13
<212> PRT
<213> Homo sapiens

<400> 227
Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg
 1               5                  10

<210> 228
<211> 10
<212> PRT
<213> Homo sapiens

<400> 228
Phe Ser Pro Gln Trp Ser His His Gly Lys
 1               5                  10

<210> 229
<211> 13
<212> PRT
<213> Homo sapiens

<400> 229
His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
 1               5                  10

<210> 230
<211> 20
<212> PRT
<213> Homo sapiens

<400> 230
Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile
 1               5                  10                  15
Asp Ala Ala Lys
            20

<210> 231
<211> 15
<212> PRT
<213> Homo sapiens

<400> 231
Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg
 1               5                  10                  15

<210> 232
<211> 11
<212> PRT
<213> Homo sapiens

<400> 232
Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys
 1               5                  10

<210> 233
<211> 9
<212> PRT
<213> Homo sapiens

<400> 233
Phe Ala Gly Val Phe His Val Glu Lys
 1               5

<210> 234
<211> 11
<212> PRT
<213> Homo sapiens

<400> 234
Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln Lys
 1               5                  10

<210> 235
<211> 9
<212> PRT
<213> Homo sapiens

<400> 235
Lys Tyr Gly Asn Leu Ser Asn Phe Leu
 1               5

<210> 236
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 236
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser
    370                 375                 380
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe
                565                 570                 575
Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Lys
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 237
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 237
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser
    370                 375                 380
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe
                565                 570                 575
Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Lys
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 238
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 238
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser
    370                 375                 380
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Trp Val Leu
                565                 570                 575
Asp Tyr Ser Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Glu
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 239
<211> 222
<212> PRT
<213> Homo sapiens

<400> 239
Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys Lys
 1               5                  10                  15
Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys Leu
            20                  25                  30
Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser Ser
        35                  40                  45
Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly Ser
    50                  55                  60
Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser Asp
65                  70                  75                  80
Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met Asn
                85                  90                  95
Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn Asn
            100                 105                 110
Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn Pro
        115                 120                 125
Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser Arg
    130                 135                 140
Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp Ser
145                 150                 155                 160
Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu Asn
                165                 170                 175
Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met Ala
            180                 185                 190
His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg Glu
        195                 200                 205
Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys
    210                 215                 220

<210> 240
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 240
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Gly Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Val Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Val Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Ala Lys Trp Lys Asn Asn Thr Leu Ser
    370                 375                 380
Leu Ser His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe
                565                 570                 575
Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Ser Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Val
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Asn Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Gly Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Glu Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Leu Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Gly Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Lys
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 241
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 241
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser
    370                 375                 380
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Trp Val Leu
                565                 570                 575
Asp Tyr Ser Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Glu
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 242
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 242
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser
    370                 375                 380
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe
                565                 570                 575
Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Lys
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 243
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 243
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser
    370                 375                 380
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Trp Val Leu
                565                 570                 575
Asp Tyr Ser Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Glu
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 244
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 244
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser
    370                 375                 380
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Trp Val Leu
                565                 570                 575
Asp Tyr Ser Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Glu
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 245
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 245
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser
    370                 375                 380
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe
                565                 570                 575
Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Lys
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 246
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 246
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu
 1               5                  10                  15
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro
            20                  25                  30
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu
        35                  40                  45
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro
    50                  55                  60
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys
65                  70                  75                  80
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His
                85                  90                  95
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met
            100                 105                 110
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His
        115                 120                 125
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe
    130                 135                 140
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys
145                 150                 155                 160
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile
                165                 170                 175
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp
            180                 185                 190
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr
        195                 200                 205
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser
    210                 215                 220
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu
225                 230                 235                 240
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile
                245                 250                 255
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe
            260                 265                 270
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu
        275                 280                 285
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser
    290                 295                 300
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys
305                 310                 315                 320
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro
                325                 330                 335
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu
            340                 345                 350
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys
        355                 360                 365
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser
    370                 375                 380
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu
385                 390                 395                 400
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe
                405                 410                 415
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn
            420                 425                 430
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu
        435                 440                 445
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu
    450                 455                 460
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val
465                 470                 475                 480
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met
                485                 490                 495
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu
            500                 505                 510
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe
        515                 520                 525
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val
    530                 535                 540
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met
545                 550                 555                 560
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe
                565                 570                 575
Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys
            580                 585                 590
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu
        595                 600                 605
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly
    610                 615                 620
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile
625                 630                 635                 640
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu
                645                 650                 655
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg
            660                 665                 670
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly
        675                 680                 685
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr
    690                 695                 700
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu
705                 710                 715                 720
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn
                725                 730                 735
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser
            740                 745                 750
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly
        755                 760                 765
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly
    770                 775                 780
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys
785                 790                 795                 800
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn
                805                 810                 815
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu
            820                 825                 830
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys
        835                 840                 845
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser
    850                 855                 860
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys
865                 870                 875                 880
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys
                885                 890                 895
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser
            900                 905                 910
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly
        915                 920                 925
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser
    930                 935                 940
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met
945                 950                 955                 960
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn
                965                 970                 975
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn
            980                 985                 990
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser
        995                 1000                1005
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp
    1010                1015                1020
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met
                1045                1050                1055
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg
            1060                1065                1070
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg
        1075                1080                1085
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr
    1090                1095                1100
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val
                1125                1130                1135
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln
            1140                1145                1150
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn
        1155                1160                1165
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr
    1170                1175                1180
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser
                1205                1210                1215
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser
            1220                1225                1230
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile
        1235                1240                1245
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu
    1250                1255                1260
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val
                1285                1290                1295
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser
            1300                1305                1310
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu
        1315                1320                1325
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe
    1330                1335                1340
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg
                1365                1370                1375
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro
            1380                1385                1390
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr
        1395                1400                1405
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile
    1410                1415                1420
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Lys
                1445                1450                1455
Met Pro Ser Ile Glu Ser Asp Val
            1460

<210> 247
<211> 630
<212> PRT
<213> Homo sapiens

<400> 247
Met Ala Glu Leu Cys Pro Leu Ala Glu Glu Leu Ser Cys Ser Ile Cys
 1               5                  10                  15
Leu Glu Pro Phe Lys Glu Pro Val Thr Thr Pro Cys Gly His Asn Phe
            20                  25                  30
Cys Gly Ser Cys Leu Asn Glu Thr Trp Ala Val Gln Gly Ser Pro Tyr
        35                  40                  45
Leu Cys Pro Gln Cys Arg Ala Val Tyr Gln Ala Arg Pro Gln Leu His
    50                  55                  60
Lys Asn Thr Val Leu Cys Asn Val Val Glu Gln Phe Leu Gln Ala Asp
65                  70                  75                  80
Leu Ala Arg Glu Pro Pro Ala Asp Val Trp Thr Pro Pro Ala Arg Ala
                85                  90                  95
Ser Ala Pro Ser Pro Asn Ala Gln Val Ala Cys Asp His Cys Leu Lys
            100                 105                 110
Glu Ala Ala Val Lys Thr Cys Leu Val Cys Met Ala Ser Phe Cys Gln
        115                 120                 125
Glu His Leu Gln Pro His Phe Asp Ser Pro Ala Phe Gln Asp His Pro
    130                 135                 140
Leu Gln Pro Pro Val Arg Asp Leu Leu Arg Arg Lys Cys Ser Gln His
145                 150                 155                 160
Asn Arg Leu Arg Glu Phe Phe Cys Pro Glu His Ser Glu Cys Ile Cys
                165                 170                 175
His Ile Cys Leu Val Glu His Lys Thr Cys Ser Pro Ala Ser Leu Ser
            180                 185                 190
Gln Ala Ser Ala Asp Leu Glu Ala Thr Leu Arg His Lys Leu Thr Val
        195                 200                 205
Met Tyr Ser Gln Ile Asn Gly Ala Ser Arg Ala Leu Asp Asp Val Arg
    210                 215                 220
Asn Arg Gln Gln Asp Val Arg Met Thr Ala Asn Arg Lys Val Glu Gln
225                 230                 235                 240
Leu Gln Gln Glu Tyr Thr Glu Met Lys Ala Leu Leu Asp Ala Ser Glu
                245                 250                 255
Thr Thr Ser Thr Arg Lys Ile Lys Glu Glu Glu Lys Arg Val Asn Ser
            260                 265                 270
Lys Phe Asp Thr Ile Tyr Gln Ile Leu Leu Lys Lys Lys Ser Glu Ile
        275                 280                 285
Gln Thr Leu Lys Glu Glu Ile Glu Gln Ser Leu Thr Lys Arg Asp Glu
    290                 295                 300
Phe Glu Phe Leu Glu Lys Ala Ser Lys Leu Arg Gly Ile Ser Thr Lys
305                 310                 315                 320
Pro Val Tyr Ile Pro Glu Val Glu Leu Asn His Lys Leu Ile Lys Gly
                325                 330                 335
Ile His Gln Ser Thr Ile Asp Leu Lys Asn Glu Leu Lys Gln Cys Ile
            340                 345                 350
Gly Arg Leu Gln Glu Leu Thr Pro Ser Ser Gly Asp Pro Gly Glu His
        355                 360                 365
Asp Pro Ala Ser Thr His Lys Ser Thr Arg Pro Val Lys Lys Val Ser
    370                 375                 380
Lys Glu Glu Lys Lys Ser Lys Lys Pro Pro Pro Val Pro Ala Leu Pro
385                 390                 395                 400
Ser Lys Leu Pro Thr Phe Gly Ala Pro Glu Gln Leu Val Asp Leu Lys
                405                 410                 415
Gln Ala Gly Leu Glu Ala Ala Ala Lys Ala Thr Ser Ser His Pro Asn
            420                 425                 430
Ser Thr Ser Leu Lys Ala Lys Val Leu Glu Thr Phe Leu Ala Lys Ser
        435                 440                 445
Arg Pro Glu Leu Leu Glu Tyr Tyr Ile Lys Val Ile Leu Asp Tyr Asn
    450                 455                 460
Thr Ala His Asn Lys Val Ala Leu Ser Glu Cys Tyr Thr Val Ala Ser
465                 470                 475                 480
Val Ala Glu Met Pro Gln Asn Tyr Arg Pro His Pro Gln Arg Phe Thr
                485                 490                 495
Tyr Cys Ser Gln Val Leu Gly Leu His Cys Tyr Lys Lys Gly Ile His
            500                 505                 510
Tyr Trp Glu Val Glu Leu Gln Lys Asn Asn Phe Cys Gly Val Gly Ile
        515                 520                 525
Cys Tyr Gly Ser Met Asn Arg Gln Gly Pro Glu Ser Arg Leu Gly Arg
    530                 535                 540
Asn Ser Ala Ser Trp Cys Val Glu Trp Phe Asn Thr Lys Ile Ser Ala
545                 550                 555                 560
Trp His Asn Asn Val Glu Lys Thr Leu Pro Ser Thr Lys Ala Thr Arg
                565                 570                 575
Val Gly Val Leu Leu Asn Cys Asp His Gly Phe Val Ile Phe Phe Ala
            580                 585                 590
Val Ala Asp Lys Val His Leu Met Tyr Lys Phe Arg Val Asp Phe Thr
        595                 600                 605
Glu Ala Leu Tyr Pro Ala Phe Trp Val Phe Ser Ala Gly Ala Thr Leu
    610                 615                 620
Ser Ile Cys Ser Pro Lys
625                 630

<210> 248
<211> 630
<212> PRT
<213> Homo sapiens

<400> 248
Met Ala Glu Leu Cys Pro Leu Ala Glu Glu Leu Ser Cys Ser Ile Cys
 1               5                  10                  15
Leu Glu Pro Phe Lys Glu Pro Val Thr Thr Pro Cys Gly His Asn Phe
            20                  25                  30
Cys Gly Ser Cys Leu Asn Glu Thr Trp Ala Val Gln Gly Ser Pro Tyr
        35                  40                  45
Leu Cys Pro Gln Cys Arg Ala Val Tyr Gln Ala Arg Pro Gln Leu His
    50                  55                  60
Lys Asn Thr Val Leu Cys Asn Val Val Glu Gln Phe Leu Gln Ala Asp
65                  70                  75                  80
Leu Ala Arg Glu Pro Pro Ala Asp Val Trp Thr Pro Pro Ala Arg Ala
                85                  90                  95
Ser Ala Pro Ser Pro Asn Ala Gln Val Ala Cys Asp His Cys Leu Lys
            100                 105                 110
Glu Ala Ala Val Lys Thr Cys Leu Val Cys Met Ala Ser Phe Cys Gln
        115                 120                 125
Glu His Leu Gln Pro His Phe Asp Ser Pro Ala Phe Gln Asp His Pro
    130                 135                 140
Leu Gln Pro Pro Val Arg Asp Leu Leu Arg Arg Lys Cys Ser Gln His
145                 150                 155                 160
Asn Arg Leu Arg Glu Phe Phe Cys Pro Glu His Ser Glu Cys Ile Cys
                165                 170                 175
His Ile Cys Leu Val Glu His Lys Thr Cys Ser Pro Ala Ser Leu Ser
            180                 185                 190
Gln Ala Ser Ala Asp Leu Glu Ala Thr Leu Arg His Lys Leu Thr Val
        195                 200                 205
Met Tyr Ser Gln Ile Asn Gly Ala Ser Arg Ala Leu Asp Asp Val Arg
    210                 215                 220
Asn Arg Gln Gln Asp Val Arg Met Thr Ala Asn Arg Lys Val Glu Gln
225                 230                 235                 240
Leu Gln Gln Glu Tyr Thr Glu Met Lys Ala Leu Leu Asp Ala Ser Glu
                245                 250                 255
Thr Thr Ser Thr Arg Lys Ile Lys Glu Glu Glu Lys Arg Val Asn Ser
            260                 265                 270
Lys Phe Asp Thr Ile Tyr Gln Ile Leu Leu Lys Lys Lys Ser Glu Ile
        275                 280                 285
Gln Thr Leu Lys Glu Glu Ile Glu Gln Ser Leu Thr Lys Arg Asp Glu
    290                 295                 300
Phe Glu Phe Leu Glu Lys Ala Ser Lys Leu Arg Gly Ile Ser Thr Lys
305                 310                 315                 320
Pro Val Tyr Ile Pro Glu Val Glu Leu Asn His Lys Leu Ile Lys Gly
                325                 330                 335
Ile His Gln Ser Thr Ile Asp Leu Lys Asn Glu Leu Lys Gln Cys Ile
            340                 345                 350
Gly Arg Leu Gln Glu Leu Thr Pro Ser Ser Gly Asp Pro Gly Glu His
        355                 360                 365
Asp Pro Ala Ser Thr His Lys Ser Thr Arg Pro Val Lys Lys Val Ser
    370                 375                 380
Lys Glu Glu Lys Lys Ser Lys Lys Pro Pro Pro Val Pro Ala Leu Pro
385                 390                 395                 400
Ser Lys Leu Pro Thr Phe Gly Ala Pro Glu Gln Leu Val Asp Leu Lys
                405                 410                 415
Gln Ala Gly Leu Glu Ala Ala Ala Lys Ala Thr Ser Ser His Pro Asn
            420                 425                 430
Ser Thr Ser Leu Lys Ala Lys Val Leu Glu Thr Phe Leu Ala Lys Ser
        435                 440                 445
Arg Pro Glu Leu Leu Glu Tyr Tyr Ile Lys Val Ile Leu Asp Tyr Asn
    450                 455                 460
Thr Ala His Asn Lys Val Ala Leu Ser Glu Cys Tyr Thr Val Ala Ser
465                 470                 475                 480
Val Ala Glu Met Pro Gln Asn Tyr Arg Pro His Pro Gln Arg Phe Thr
                485                 490                 495
Tyr Cys Ser Gln Val Leu Gly Leu His Cys Tyr Lys Lys Gly Ile His
            500                 505                 510
Tyr Trp Glu Val Glu Leu Gln Lys Asn Asn Phe Cys Gly Val Gly Ile
        515                 520                 525
Cys Tyr Gly Ser Met Asn Arg Gln Gly Pro Glu Ser Arg Leu Gly Arg
    530                 535                 540
Asn Ser Ala Ser Trp Cys Val Glu Trp Phe Asn Thr Lys Ile Ser Ala
545                 550                 555                 560
Trp His Asn Asn Val Glu Lys Thr Leu Pro Ser Thr Lys Ala Thr Arg
                565                 570                 575
Val Gly Val Leu Leu Asn Cys Asp His Gly Phe Val Ile Phe Phe Ala
            580                 585                 590
Val Ala Asp Lys Val His Leu Met Tyr Lys Phe Arg Val Asp Phe Thr
        595                 600                 605
Glu Ala Leu Tyr Pro Ala Phe Trp Val Phe Ser Ala Gly Ala Thr Leu
    610                 615                 620
Ser Ile Cys Ser Pro Lys
625                 630

<210> 249
<211> 630
<212> PRT
<213> Homo sapiens

<400> 249
Met Ala Glu Leu Cys Pro Leu Ala Glu Glu Leu Ser Cys Ser Ile Cys
 1               5                  10                  15
Leu Glu Pro Phe Lys Glu Pro Val Thr Thr Pro Cys Gly His Asn Phe
            20                  25                  30
Cys Gly Ser Cys Leu Asn Glu Thr Trp Ala Val Gln Gly Ser Pro Tyr
        35                  40                  45
Leu Cys Pro Gln Cys Arg Ala Val Tyr Gln Ala Arg Pro Gln Leu His
    50                  55                  60
Lys Asn Thr Val Leu Cys Asn Val Val Glu Gln Phe Leu Gln Ala Asp
65                  70                  75                  80
Leu Ala Arg Glu Pro Pro Ala Asp Val Trp Thr Pro Pro Ala Arg Ala
                85                  90                  95
Ser Ala Pro Ser Pro Asn Ala Gln Val Ala Cys Asp His Cys Leu Lys
            100                 105                 110
Glu Ala Ala Val Lys Thr Cys Leu Val Cys Met Ala Ser Phe Cys Gln
        115                 120                 125
Glu His Leu Gln Pro His Phe Asp Ser Pro Ala Phe Gln Asp His Pro
    130                 135                 140
Leu Gln Pro Pro Val Arg Asp Leu Leu Arg Arg Lys Cys Ser Gln His
145                 150                 155                 160
Asn Arg Leu Arg Glu Phe Phe Cys Pro Glu His Ser Glu Cys Ile Cys
                165                 170                 175
His Ile Cys Leu Val Glu His Lys Thr Cys Ser Pro Ala Ser Leu Ser
            180                 185                 190
Gln Ala Ser Ala Asp Leu Glu Ala Thr Leu Arg His Lys Leu Thr Val
        195                 200                 205
Met Tyr Ser Gln Ile Asn Gly Ala Ser Arg Ala Leu Asp Asp Val Arg
    210                 215                 220
Asn Arg Gln Gln Asp Val Arg Met Thr Ala Asn Arg Lys Val Glu Gln
225                 230                 235                 240
Leu Gln Gln Glu Tyr Thr Glu Met Lys Ala Leu Leu Asp Ala Ser Glu
                245                 250                 255
Thr Thr Ser Thr Arg Lys Ile Lys Glu Glu Glu Lys Arg Val Asn Ser
            260                 265                 270
Lys Phe Asp Thr Ile Tyr Gln Ile Leu Leu Lys Lys Lys Ser Glu Ile
        275                 280                 285
Gln Thr Leu Lys Glu Glu Ile Glu Gln Ser Leu Thr Lys Arg Asp Glu
    290                 295                 300
Phe Glu Phe Leu Glu Lys Ala Ser Lys Leu Arg Gly Ile Ser Thr Lys
305                 310                 315                 320
Pro Val Tyr Ile Pro Glu Val Glu Leu Asn His Lys Leu Ile Lys Gly
                325                 330                 335
Ile His Gln Ser Thr Ile Asp Leu Lys Asn Glu Leu Lys Gln Cys Ile
            340                 345                 350
Gly Arg Leu Gln Glu Leu Thr Pro Ser Ser Gly Asp Pro Gly Glu His
        355                 360                 365
Asp Pro Ala Ser Thr His Lys Ser Thr Arg Pro Val Lys Lys Val Ser
    370                 375                 380
Lys Glu Glu Lys Lys Ser Lys Lys Pro Pro Pro Val Pro Ala Leu Pro
385                 390                 395                 400
Ser Lys Leu Pro Thr Phe Gly Ala Pro Glu Gln Leu Val Asp Leu Lys
                405                 410                 415
Gln Ala Gly Leu Glu Ala Ala Ala Lys Ala Thr Ser Ser His Pro Asn
            420                 425                 430
Ser Thr Ser Leu Lys Ala Lys Val Leu Glu Thr Phe Leu Ala Lys Ser
        435                 440                 445
Arg Pro Glu Leu Leu Glu Tyr Tyr Ile Lys Val Ile Leu Asp Tyr Asn
    450                 455                 460
Thr Ala His Asn Lys Val Ala Leu Ser Glu Cys Tyr Thr Val Ala Ser
465                 470                 475                 480
Val Ala Glu Met Pro Gln Asn Tyr Arg Pro His Pro Gln Arg Phe Thr
                485                 490                 495
Tyr Cys Ser Gln Val Leu Gly Leu His Cys Tyr Lys Lys Gly Ile His
            500                 505                 510
Tyr Trp Glu Val Glu Leu Gln Lys Asn Asn Phe Cys Gly Val Gly Ile
        515                 520                 525
Cys Tyr Gly Ser Met Asn Arg Gln Gly Pro Glu Ser Arg Leu Gly Arg
    530                 535                 540
Asn Ser Ala Ser Trp Cys Val Glu Trp Phe Asn Thr Lys Ile Ser Ala
545                 550                 555                 560
Trp His Asn Asn Val Glu Lys Thr Leu Pro Ser Thr Lys Ala Thr Arg
                565                 570                 575
Val Gly Val Leu Leu Asn Cys Asp His Gly Phe Val Ile Phe Phe Ala
            580                 585                 590
Val Ala Asp Lys Val His Leu Met Tyr Lys Phe Arg Val Asp Phe Thr
        595                 600                 605
Glu Ala Leu Tyr Pro Ala Phe Trp Val Phe Ser Ala Gly Ala Thr Leu
    610                 615                 620
Ser Ile Cys Ser Pro Lys
625                 630

<210> 250
<211> 179
<212> PRT
<213> Homo sapiens

<400> 250
Met Val Ala Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp Leu Tyr Gly
 1               5                  10                  15
Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala Trp Phe Ile
            20                  25                  30
Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val Thr Ala Phe
        35                  40                  45
Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr Ile Cys Arg
    50                  55                  60
Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp Leu Arg Gln
65                  70                  75                  80
Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys Thr Val Ser
                85                  90                  95
Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn Met Thr Phe
            100                 105                 110
His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala Val Ile Ala
        115                 120                 125
Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala Tyr Val Lys
    130                 135                 140
Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser Lys Glu Glu
145                 150                 155                 160
Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu Arg Leu Asn
                165                 170                 175
Ala Tyr Thr


<210> 251
<211> 278
<212> PRT
<213> Homo sapiens

<400> 251
Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu
 1               5                  10                  15
Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala
            20                  25                  30
Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His
        35                  40                  45
Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met
    50                  55                  60
Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile
65                  70                  75                  80
Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly
                85                  90                  95
Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp
            100                 105                 110
Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala
        115                 120                 125
Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val
    130                 135                 140
Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr
145                 150                 155                 160
Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp
                165                 170                 175
Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys
            180                 185                 190
Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn
        195                 200                 205
Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala
    210                 215                 220
Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala
225                 230                 235                 240
Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser
                245                 250                 255
Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu
            260                 265                 270
Arg Leu Asn Ala Tyr Thr
        275

<210> 252
<211> 51
<212> PRT
<213> Homo sapiens

<400> 252
Met Cys Glu Ser Thr Glu Leu Asn Met Thr Phe His Leu Phe Ile Val
 1               5                  10                  15
Ala Leu Ala Gly Ala Gly Ala Ala Val Ile Ala Met Val His Tyr Leu
            20                  25                  30
Met Val Leu Ser Ala Asn Trp Ala Tyr Val Lys Asp Ala Cys Arg Met
        35                  40                  45
Ala Glu Val
    50

<210> 253
<211> 278
<212> PRT
<213> Homo sapiens

<400> 253
Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu
 1               5                  10                  15
Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala
            20                  25                  30
Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His
        35                  40                  45
Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met
    50                  55                  60
Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile
65                  70                  75                  80
Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly
                85                  90                  95
Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp
            100                 105                 110
Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala
        115                 120                 125
Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val
    130                 135                 140
Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr
145                 150                 155                 160
Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp
                165                 170                 175
Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys
            180                 185                 190
Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn
        195                 200                 205
Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala
    210                 215                 220
Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala
225                 230                 235                 240
Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser
                245                 250                 255
Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu
            260                 265                 270
Arg Leu Asn Ala Tyr Thr
        275

<210> 254
<211> 278
<212> PRT
<213> Homo sapiens

<400> 254
Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu
 1               5                  10                  15
Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala
            20                  25                  30
Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His
        35                  40                  45
Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met
    50                  55                  60
Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile
65                  70                  75                  80
Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly
                85                  90                  95
Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp
            100                 105                 110
Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala
        115                 120                 125
Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val
    130                 135                 140
Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr
145                 150                 155                 160
Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp
                165                 170                 175
Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys
            180                 185                 190
Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn
        195                 200                 205
Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala
    210                 215                 220
Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala
225                 230                 235                 240
Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser
                245                 250                 255
Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu
            260                 265                 270
Arg Leu Asn Ala Tyr Thr
        275

<210> 255
<211> 278
<212> PRT
<213> Homo sapiens

<400> 255
Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu
 1               5                  10                  15
Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala
            20                  25                  30
Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His
        35                  40                  45
Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met
    50                  55                  60
Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile
65                  70                  75                  80
Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly
                85                  90                  95
Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp
            100                 105                 110
Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala
        115                 120                 125
Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val
    130                 135                 140
Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr
145                 150                 155                 160
Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp
                165                 170                 175
Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys
            180                 185                 190
Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn
        195                 200                 205
Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala
    210                 215                 220
Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala
225                 230                 235                 240
Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser
                245                 250                 255
Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu
            260                 265                 270
Arg Leu Asn Ala Tyr Thr
        275

<210> 256
<211> 193
<212> PRT
<213> Homo sapiens

<400> 256
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly
 1               5                  10                  15
Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile
            20                  25                  30
Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu
        35                  40                  45
Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His
    50                  55                  60
Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala
65                  70                  75                  80
Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu
                85                  90                  95
Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu
            100                 105                 110
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu
        115                 120                 125
Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg
    130                 135                 140
Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro
145                 150                 155                 160
Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu
                165                 170                 175
Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg
            180                 185                 190
Pro


<210> 257
<211> 193
<212> PRT
<213> Homo sapiens

<400> 257
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly
 1               5                  10                  15
Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile
            20                  25                  30
Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu
        35                  40                  45
Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His
    50                  55                  60
Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala
65                  70                  75                  80
Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu
                85                  90                  95
Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu
            100                 105                 110
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu
        115                 120                 125
Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg
    130                 135                 140
Leu Ser Phe His Gln Gly Cys Thr Ile Val Ser Gln Arg Leu Thr Pro
145                 150                 155                 160
Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu
                165                 170                 175
Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg
            180                 185                 190
Pro


<210> 258
<211> 193
<212> PRT
<213> Homo sapiens

<400> 258
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly
 1               5                  10                  15
Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile
            20                  25                  30
Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu
        35                  40                  45
Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His
    50                  55                  60
Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala
65                  70                  75                  80
Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu
                85                  90                  95
Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu
            100                 105                 110
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu
        115                 120                 125
Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg
    130                 135                 140
Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro
145                 150                 155                 160
Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu
                165                 170                 175
Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg
            180                 185                 190
Pro


<210> 259
<211> 193
<212> PRT
<213> Homo sapiens

<400> 259
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly
 1               5                  10                  15
Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile
            20                  25                  30
Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu
        35                  40                  45
Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His
    50                  55                  60
Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala
65                  70                  75                  80
Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu
                85                  90                  95
Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu
            100                 105                 110
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu
        115                 120                 125
Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg
    130                 135                 140
Leu Ser Phe His Gln Gly Cys Thr Ile Val Ser Gln Arg Leu Thr Pro
145                 150                 155                 160
Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu
                165                 170                 175
Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg
            180                 185                 190
Pro


<210> 260
<211> 216
<212> PRT
<213> Homo sapiens

<400> 260
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile
 1               5                  10                  15
Leu Val Leu Leu Pro Val Thr Ser Ser Asp Arg Met Lys Gln Ile Glu
            20                  25                  30
Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr His Ile Glu Asn Glu
        35                  40                  45
Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Arg Thr Ser Gln Arg Phe
    50                  55                  60
Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val
65                  70                  75                  80
Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu
                85                  90                  95
Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly Pro
            100                 105                 110
Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile Tyr Met
        115                 120                 125
Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr Thr Ala Ser
    130                 135                 140
Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ser
145                 150                 155                 160
Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly Cys Thr Ile
                165                 170                 175
Val Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr
            180                 185                 190
Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe
        195                 200                 205
Phe Gly Val Gln Trp Val Arg Pro
    210                 215

<210> 261
<211> 216
<212> PRT
<213> Homo sapiens

<400> 261
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile
 1               5                  10                  15
Leu Val Leu Leu Pro Val Thr Ser Ser Asp Arg Met Lys Gln Ile Glu
            20                  25                  30
Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr His Ile Glu Asn Glu
        35                  40                  45
Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Arg Thr Ser Gln Arg Phe
    50                  55                  60
Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val
65                  70                  75                  80
Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu
                85                  90                  95
Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly Pro
            100                 105                 110
Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile Tyr Met
        115                 120                 125
Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr Thr Ala Ser
    130                 135                 140
Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ser
145                 150                 155                 160
Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly Cys Thr Ile
                165                 170                 175
Val Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr
            180                 185                 190
Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe
        195                 200                 205
Phe Gly Val Gln Trp Val Arg Pro
    210                 215

<210> 262
<211> 193
<212> PRT
<213> Homo sapiens

<400> 262
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly
 1               5                  10                  15
Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile
            20                  25                  30
Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu
        35                  40                  45
Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His
    50                  55                  60
Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala
65                  70                  75                  80
Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu
                85                  90                  95
Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu
            100                 105                 110
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu
        115                 120                 125
Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg
    130                 135                 140
Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro
145                 150                 155                 160
Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu
                165                 170                 175
Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg
            180                 185                 190
Pro


<210> 263
<211> 193
<212> PRT
<213> Homo sapiens

<400> 263
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly
 1               5                  10                  15
Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile
            20                  25                  30
Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu
        35                  40                  45
Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His
    50                  55                  60
Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala
65                  70                  75                  80
Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu
                85                  90                  95
Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu
            100                 105                 110
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu
        115                 120                 125
Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg
    130                 135                 140
Leu Ser Phe His Gln Gly Cys Thr Ile Val Ser Gln Arg Leu Thr Pro
145                 150                 155                 160
Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu
                165                 170                 175
Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg
            180                 185                 190
Pro


<210> 264
<211> 193
<212> PRT
<213> Homo sapiens

<400> 264
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly
 1               5                  10                  15
Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile
            20                  25                  30
Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu
        35                  40                  45
Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His
    50                  55                  60
Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala
65                  70                  75                  80
Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu
                85                  90                  95
Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu
            100                 105                 110
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu
        115                 120                 125
Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg
    130                 135                 140
Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro
145                 150                 155                 160
Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu
                165                 170                 175
Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg
            180                 185                 190
Pro


<210> 265
<211> 38
<212> PRT
<213> Homo sapiens

<400> 265
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala
        35

<210> 266
<211> 369
<212> PRT
<213> Homo sapiens

<400> 266
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe
                245                 250                 255
Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu
            260                 265                 270
Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro
        275                 280                 285
Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His
    290                 295                 300
Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser
305                 310                 315                 320
Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro
                325                 330                 335
Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn
            340                 345                 350
Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu
        355                 360                 365
Thr


<210> 267
<211> 369
<212> PRT
<213> Homo sapiens

<400> 267
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe
                245                 250                 255
Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu
            260                 265                 270
Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro
        275                 280                 285
Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His
    290                 295                 300
Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser
305                 310                 315                 320
Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro
                325                 330                 335
Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn
            340                 345                 350
Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu
        355                 360                 365
Thr


<210> 268
<211> 369
<212> PRT
<213> Homo sapiens

<400> 268
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe
                245                 250                 255
Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu
            260                 265                 270
Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro
        275                 280                 285
Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His
    290                 295                 300
Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser
305                 310                 315                 320
Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro
                325                 330                 335
Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn
            340                 345                 350
Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu
        355                 360                 365
Thr


<210> 269
<211> 369
<212> PRT
<213> Homo sapiens

<400> 269
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe
                245                 250                 255
Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu
            260                 265                 270
Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro
        275                 280                 285
Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His
    290                 295                 300
Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser
305                 310                 315                 320
Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro
                325                 330                 335
Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn
            340                 345                 350
Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu
        355                 360                 365
Thr


<210> 270
<211> 121
<212> PRT
<213> Homo sapiens

<400> 270
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu
        115                 120

<210> 271
<211> 369
<212> PRT
<213> Homo sapiens

<400> 271
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe
                245                 250                 255
Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu
            260                 265                 270
Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro
        275                 280                 285
Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His
    290                 295                 300
Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser
305                 310                 315                 320
Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro
                325                 330                 335
Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn
            340                 345                 350
Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu
        355                 360                 365
Thr


<210> 272
<211> 252
<212> PRT
<213> Homo sapiens

<400> 272
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys
                245                 250

<210> 273
<211> 38
<212> PRT
<213> Homo sapiens

<400> 273
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala
        35

<210> 274
<211> 482
<212> PRT
<213> Homo sapiens

<400> 274
Met Val Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Met Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Val Asp
                245                 250                 255
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
            260                 265                 270
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
        275                 280                 285
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
    290                 295                 300
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
305                 310                 315                 320
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
                325                 330                 335
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
            340                 345                 350
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
        355                 360                 365
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
    370                 375                 380
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
385                 390                 395                 400
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
                405                 410                 415
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
            420                 425                 430
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
        435                 440                 445
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
    450                 455                 460
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
465                 470                 475                 480
Gly Lys


<210> 275
<211> 694
<212> PRT
<213> Homo sapiens

<400> 275
Met Val Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Ala Ser
                245                 250                 255
Ser Gly Asn Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr
            260                 265                 270
Met Ser Ile Ser Thr Cys Glu Trp Lys Met Asp Gly Pro Thr Asn Cys
        275                 280                 285
Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu
    290                 295                 300
Ala His Thr Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys
305                 310                 315                 320
His Leu Leu Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp
                325                 330                 335
Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser
            340                 345                 350
Glu His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn
        355                 360                 365
Val Ser Asp Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp
    370                 375                 380
Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu
385                 390                 395                 400
Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro
                405                 410                 415
Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg
            420                 425                 430
Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu
        435                 440                 445
Trp Ser Pro Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu
    450                 455                 460
Gln Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
465                 470                 475                 480
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                485                 490                 495
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            500                 505                 510
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        515                 520                 525
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    530                 535                 540
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
545                 550                 555                 560
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                565                 570                 575
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            580                 585                 590
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
        595                 600                 605
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    610                 615                 620
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
625                 630                 635                 640
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                645                 650                 655
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            660                 665                 670
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        675                 680                 685
Ser Leu Ser Pro Gly Lys
    690

<210> 276
<211> 691
<212> PRT
<213> Homo sapiens

<400> 276
Met Val Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Gly Asn
                245                 250                 255
Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met Ser Ile
            260                 265                 270
Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser Thr Glu
        275                 280                 285
Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala His Thr
    290                 295                 300
Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His Leu Leu
305                 310                 315                 320
Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu Trp Ala
                325                 330                 335
Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu His Val
            340                 345                 350
Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn Val Ser Asp
        355                 360                 365
Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn Tyr Leu
    370                 375                 380
Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn Asp Pro
385                 390                 395                 400
Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg
                405                 410                 415
Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala Arg Val
            420                 425                 430
Arg Ala Trp Ala Gln Ser Tyr Asn Thr Thr Trp Ser Glu Trp Ser Pro
        435                 440                 445
Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln Ser Gly
    450                 455                 460
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
465                 470                 475                 480
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                485                 490                 495
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            500                 505                 510
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        515                 520                 525
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    530                 535                 540
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
545                 550                 555                 560
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                565                 570                 575
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            580                 585                 590
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        595                 600                 605
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    610                 615                 620
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
625                 630                 635                 640
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                645                 650                 655
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            660                 665                 670
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        675                 680                 685
Pro Gly Lys
    690

<210> 277
<211> 694
<212> PRT
<213> Homo sapiens

<400> 277
Met Val Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Ala Ser
                245                 250                 255
Ser Gly Asn Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr
            260                 265                 270
Met Ser Ile Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys
        275                 280                 285
Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu
    290                 295                 300
Ala His Thr Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys
305                 310                 315                 320
His Leu Leu Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp
                325                 330                 335
Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser
            340                 345                 350
Glu His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn
        355                 360                 365
Val Ser Asp Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp
    370                 375                 380
Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu
385                 390                 395                 400
Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro
                405                 410                 415
Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg
            420                 425                 430
Ala Arg Val Arg Ala Trp Ala Gln Ser Tyr Asn Thr Thr Trp Ser Glu
        435                 440                 445
Trp Ser Pro Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu
    450                 455                 460
Gln Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
465                 470                 475                 480
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                485                 490                 495
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            500                 505                 510
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        515                 520                 525
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    530                 535                 540
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
545                 550                 555                 560
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                565                 570                 575
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            580                 585                 590
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        595                 600                 605
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    610                 615                 620
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
625                 630                 635                 640
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                645                 650                 655
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            660                 665                 670
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        675                 680                 685
Ser Leu Ser Pro Gly Lys
    690

<210> 278
<211> 369
<212> PRT
<213> Homo sapiens

<400> 278
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe
                245                 250                 255
Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu
            260                 265                 270
Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro
        275                 280                 285
Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His
    290                 295                 300
Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser
305                 310                 315                 320
Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro
                325                 330                 335
Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn
            340                 345                 350
Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu
        355                 360                 365
Thr


<210> 279
<211> 369
<212> PRT
<213> Homo sapiens

<400> 279
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe
                245                 250                 255
Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu
            260                 265                 270
Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro
        275                 280                 285
Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His
    290                 295                 300
Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser
305                 310                 315                 320
Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro
                325                 330                 335
Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn
            340                 345                 350
Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu
        355                 360                 365
Thr


<210> 280
<211> 1181
<212> PRT
<213> Homo sapiens

<400> 280
Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val
 1               5                  10                  15
Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val
            20                  25                  30
Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe
        35                  40                  45
Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu
    50                  55                  60
Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val
65                  70                  75                  80
Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn
                85                  90                  95
Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn
            100                 105                 110
Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe
        115                 120                 125
Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr
    130                 135                 140
Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala
145                 150                 155                 160
Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val
                165                 170                 175
Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys
            180                 185                 190
Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys
        195                 200                 205
Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe
    210                 215                 220
Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser
225                 230                 235                 240
Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile
                245                 250                 255
Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg
            260                 265                 270
Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp
        275                 280                 285
Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile
    290                 295                 300
Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu
305                 310                 315                 320
Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro
                325                 330                 335
Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu
            340                 345                 350
Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val
        355                 360                 365
Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser
    370                 375                 380
Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly
385                 390                 395                 400
Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His
                405                 410                 415
Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn
            420                 425                 430
His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu
        435                 440                 445
Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln
    450                 455                 460
Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln
465                 470                 475                 480
Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys
                485                 490                 495
Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly
            500                 505                 510
Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr
        515                 520                 525
Leu Phe Thr Ile Lys Lys Gly Ile Leu Gly Gln His Gln Phe Leu Glu
    530                 535                 540
Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala
545                 550                 555                 560
Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser
                565                 570                 575
Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His
            580                 585                 590
Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp
        595                 600                 605
Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly
    610                 615                 620
Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala
625                 630                 635                 640
Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala
                645                 650                 655
Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn
            660                 665                 670
Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr
        675                 680                 685
Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala
    690                 695                 700
Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn
705                 710                 715                 720
Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser
                725                 730                 735
Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn
            740                 745                 750
Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser
        755                 760                 765
Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro
    770                 775                 780
Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val
785                 790                 795                 800
Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val
                805                 810                 815
Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys
            820                 825                 830
Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn
        835                 840                 845
Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr
    850                 855                 860
Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr
865                 870                 875                 880
Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp
                885                 890                 895
Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala
            900                 905                 910
Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu
        915                 920                 925
Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr
    930                 935                 940
Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile
945                 950                 955                 960
Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys
                965                 970                 975
Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His
            980                 985                 990
Ile Pro Gln Tyr Thr Lys Glu Lys Asn Pro Leu Met Tyr Leu Thr Gly
        995                 1000                1005
Val Gln Thr Asp Lys Ala Gly Asp Ile Ser Cys Asn Ala Asp Ile Asn
    1010                1015                1020
Pro Leu Lys Ile Gly Gln Thr Ser Ser Ser Val Ser Phe Lys Ser Glu
1025                1030                1035                1040
Asn Phe Arg His Thr Lys Glu Leu Asn Cys Arg Thr Ala Ser Cys Ser
                1045                1050                1055
Asn Val Thr Cys Trp Leu Lys Asp Val His Met Lys Gly Glu Tyr Phe
            1060                1065                1070
Val Asn Val Thr Thr Arg Ile Trp Asn Gly Thr Phe Ala Ser Ser Thr
        1075                1080                1085
Phe Gln Thr Val Gln Leu Thr Ala Ala Ala Glu Ile Asn Thr Tyr Asn
    1090                1095                1100
Pro Glu Ile Tyr Val Ile Glu Asp Asn Thr Val Thr Ile Pro Leu Met
1105                1110                1115                1120
Ile Met Lys Pro Asp Glu Lys Ala Glu Val Pro Thr Gly Val Ile Ile
                1125                1130                1135
Gly Ser Ile Ile Ala Gly Ile Leu Leu Leu Leu Ala Leu Val Ala Ile
            1140                1145                1150
Leu Trp Lys Leu Gly Phe Phe Lys Arg Lys Tyr Glu Lys Met Thr Lys
        1155                1160                1165
Asn Pro Asp Glu Ile Asp Glu Thr Thr Glu Leu Ser Ser
    1170                1175                1180

<210> 281
<211> 1367
<212> PRT
<213> Homo sapiens

<400> 281
Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val
 1               5                  10                  15
Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val
            20                  25                  30
Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe
        35                  40                  45
Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu
    50                  55                  60
Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val
65                  70                  75                  80
Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn
                85                  90                  95
Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn
            100                 105                 110
Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe
        115                 120                 125
Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr
    130                 135                 140
Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala
145                 150                 155                 160
Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val
                165                 170                 175
Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys
            180                 185                 190
Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys
        195                 200                 205
Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe
    210                 215                 220
Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser
225                 230                 235                 240
Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile
                245                 250                 255
Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Ser Gly Arg Arg
            260                 265                 270
Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp
        275                 280                 285
Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile
    290                 295                 300
Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu
305                 310                 315                 320
Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro
                325                 330                 335
Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu
            340                 345                 350
Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val
        355                 360                 365
Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser
    370                 375                 380
Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly
385                 390                 395                 400
Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His
                405                 410                 415
Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn
            420                 425                 430
His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu
        435                 440                 445
Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln
    450                 455                 460
Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln
465                 470                 475                 480
Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys
                485                 490                 495
Ser Val Asp Leu Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly
            500                 505                 510
Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr
        515                 520                 525
Leu Phe Thr Ile Lys Lys Gly Ile Leu Gly Gln His Gln Phe Leu Glu
    530                 535                 540
Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala
545                 550                 555                 560
Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser
                565                 570                 575
Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His
            580                 585                 590
Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp
        595                 600                 605
Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly
    610                 615                 620
Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala
625                 630                 635                 640
Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala
                645                 650                 655
Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn
            660                 665                 670
Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr
        675                 680                 685
Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala
    690                 695                 700
Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn
705                 710                 715                 720
Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser
                725                 730                 735
Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn
            740                 745                 750
Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser
        755                 760                 765
Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro
    770                 775                 780
Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val
785                 790                 795                 800
Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val
                805                 810                 815
Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys
            820                 825                 830
Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn
        835                 840                 845
Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr
    850                 855                 860
Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr
865                 870                 875                 880
Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp
                885                 890                 895
Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala
            900                 905                 910
Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu
        915                 920                 925
Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr
    930                 935                 940
Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile
945                 950                 955                 960
Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys
                965                 970                 975
Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His
            980                 985                 990
Ile Pro Gln Tyr Thr Lys Glu Lys Asn Pro Leu Met Tyr Leu Thr Gly
        995                 1000                1005
Val Gln Thr Asp Lys Ala Gly Asp Ile Ser Cys Asn Ala Asp Ile Asn
    1010                1015                1020
Pro Leu Lys Ile Gly Gln Thr Ser Ser Ser Val Ser Phe Lys Ser Glu
1025                1030                1035                1040
Asn Phe Arg His Thr Lys Glu Leu Asn Cys Arg Thr Ala Ser Cys Ser
                1045                1050                1055
Asn Val Thr Cys Trp Leu Lys Asp Val His Met Lys Gly Glu Tyr Phe
            1060                1065                1070
Val Asn Val Thr Thr Arg Ile Trp Asn Gly Thr Phe Ala Ser Ser Thr
        1075                1080                1085
Phe Gln Thr Val Gln Leu Thr Ala Ala Ala Glu Ile Asn Thr Tyr Asn
    1090                1095                1100
Pro Glu Ile Tyr Val Ile Glu Asp Asn Thr Val Thr Ile Pro Leu Met
1105                1110                1115                1120
Ile Met Lys Pro Asp Glu Lys Ala Glu Val Pro Thr Asp Pro Glu Glu
                1125                1130                1135
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
            1140                1145                1150
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        1155                1160                1165
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    1170                1175                1180
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
1185                1190                1195                1200
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
                1205                1210                1215
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            1220                1225                1230
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
        1235                1240                1245
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    1250                1255                1260
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
1265                1270                1275                1280
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                1285                1290                1295
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            1300                1305                1310
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        1315                1320                1325
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
    1330                1335                1340
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
1345                1350                1355                1360
Leu Ser Leu Ser Pro Gly Lys
                1365

<210> 282
<211> 1181
<212> PRT
<213> Homo sapiens

<400> 282
Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val
 1               5                  10                  15
Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val
            20                  25                  30
Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe
        35                  40                  45
Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu
    50                  55                  60
Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val
65                  70                  75                  80
Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn
                85                  90                  95
Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn
            100                 105                 110
Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe
        115                 120                 125
Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr
    130                 135                 140
Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala
145                 150                 155                 160
Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val
                165                 170                 175
Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys
            180                 185                 190
Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys
        195                 200                 205
Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe
    210                 215                 220
Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser
225                 230                 235                 240
Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile
                245                 250                 255
Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg
            260                 265                 270
Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp
        275                 280                 285
Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile
    290                 295                 300
Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu
305                 310                 315                 320
Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro
                325                 330                 335
Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu
            340                 345                 350
Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val
        355                 360                 365
Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser
    370                 375                 380
Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly
385                 390                 395                 400
Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His
                405                 410                 415
Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn
            420                 425                 430
His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu
        435                 440                 445
Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln
    450                 455                 460
Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln
465                 470                 475                 480
Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys
                485                 490                 495
Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly
            500                 505                 510
Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr
        515                 520                 525
Leu Phe Thr Ile Lys Lys Gly Ile Leu Gly Gln His Gln Phe Leu Glu
    530                 535                 540
Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala
545                 550                 555                 560
Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser
                565                 570                 575
Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His
            580                 585                 590
Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp
        595                 600                 605
Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly
    610                 615                 620
Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala
625                 630                 635                 640
Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala
                645                 650                 655
Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn
            660                 665                 670
Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr
        675                 680                 685
Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala
    690                 695                 700
Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn
705                 710                 715                 720
Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser
                725                 730                 735
Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn
            740                 745                 750
Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser
        755                 760                 765
Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro
    770                 775                 780
Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val
785                 790                 795                 800
Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val
                805                 810                 815
Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys
            820                 825                 830
Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn
        835                 840                 845
Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr
    850                 855                 860
Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr
865                 870                 875                 880
Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp
                885                 890                 895
Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala
            900                 905                 910
Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu
        915                 920                 925
Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr
    930                 935                 940
Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile
945                 950                 955                 960
Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys
                965                 970                 975
Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His
            980                 985                 990
Ile Pro Gln Tyr Thr Lys Glu Lys Asn Pro Leu Met Tyr Leu Thr Gly
        995                 1000                1005
Val Gln Thr Asp Lys Ala Gly Asp Ile Ser Cys Asn Ala Asp Ile Asn
    1010                1015                1020
Pro Leu Lys Ile Gly Gln Thr Ser Ser Ser Val Ser Phe Lys Ser Glu
1025                1030                1035                1040
Asn Phe Arg His Thr Lys Glu Leu Asn Cys Arg Thr Ala Ser Cys Ser
                1045                1050                1055
Asn Val Thr Cys Trp Leu Lys Asp Val His Met Lys Gly Glu Tyr Phe
            1060                1065                1070
Val Asn Val Thr Thr Arg Ile Trp Asn Gly Thr Phe Ala Ser Ser Thr
        1075                1080                1085
Phe Gln Thr Val Gln Leu Thr Ala Ala Ala Glu Ile Asn Thr Tyr Asn
    1090                1095                1100
Pro Glu Ile Tyr Val Ile Glu Asp Asn Thr Val Thr Ile Pro Leu Met
1105                1110                1115                1120
Ile Met Lys Pro Asp Glu Lys Ala Glu Val Pro Thr Gly Val Ile Ile
                1125                1130                1135
Gly Ser Ile Ile Ala Gly Ile Leu Leu Leu Leu Ala Leu Val Ala Ile
            1140                1145                1150
Leu Trp Lys Leu Gly Phe Phe Lys Arg Lys Tyr Glu Lys Met Thr Lys
        1155                1160                1165
Asn Pro Asp Glu Ile Asp Glu Thr Thr Glu Leu Ser Ser
    1170                1175                1180

<210> 283
<211> 1181
<212> PRT
<213> Homo sapiens

<400> 283
Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val
 1               5                  10                  15
Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val
            20                  25                  30
Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe
        35                  40                  45
Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu
    50                  55                  60
Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val
65                  70                  75                  80
Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn
                85                  90                  95
Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn
            100                 105                 110
Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe
        115                 120                 125
Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr
    130                 135                 140
Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala
145                 150                 155                 160
Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val
                165                 170                 175
Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys
            180                 185                 190
Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys
        195                 200                 205
Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe
    210                 215                 220
Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser
225                 230                 235                 240
Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile
                245                 250                 255
Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg
            260                 265                 270
Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp
        275                 280                 285
Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile
    290                 295                 300
Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu
305                 310                 315                 320
Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro
                325                 330                 335
Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu
            340                 345                 350
Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val
        355                 360                 365
Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser
    370                 375                 380
Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly
385                 390                 395                 400
Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His
                405                 410                 415
Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn
            420                 425                 430
His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu
        435                 440                 445
Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln
    450                 455                 460
Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln
465                 470                 475                 480
Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys
                485                 490                 495
Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly
            500                 505                 510
Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr
        515                 520                 525
Leu Phe Thr Ile Lys Lys Gly Ile Leu Gly Gln His Gln Phe Leu Glu
    530                 535                 540
Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala
545                 550                 555                 560
Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser
                565                 570                 575
Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His
            580                 585                 590
Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp
        595                 600                 605
Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly
    610                 615                 620
Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala
625                 630                 635                 640
Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala
                645                 650                 655
Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn
            660                 665                 670
Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr
        675                 680                 685
Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala
    690                 695                 700
Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn
705                 710                 715                 720
Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser
                725                 730                 735
Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn
            740                 745                 750
Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser
        755                 760                 765
Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro
    770                 775                 780
Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val
785                 790                 795                 800
Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val
                805                 810                 815
Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys
            820                 825                 830
Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn
        835                 840                 845
Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr
    850                 855                 860
Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr
865                 870                 875                 880
Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp
                885                 890                 895
Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala
            900                 905                 910
Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu
        915                 920                 925
Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr
    930                 935                 940
Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile
945                 950                 955                 960
Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys
                965                 970                 975
Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His
            980                 985                 990
Ile Pro Gln Tyr Thr Lys Glu Lys Asn Pro Leu Met Tyr Leu Thr Gly
        995                 1000                1005
Val Gln Thr Asp Lys Ala Gly Asp Ile Ser Cys Asn Ala Asp Ile Asn
    1010                1015                1020
Pro Leu Lys Ile Gly Gln Thr Ser Ser Ser Val Ser Phe Lys Ser Glu
1025                1030                1035                1040
Asn Phe Arg His Thr Lys Glu Leu Asn Cys Arg Thr Ala Ser Cys Ser
                1045                1050                1055
Asn Val Thr Cys Trp Leu Lys Asp Val His Met Lys Gly Glu Tyr Phe
            1060                1065                1070
Val Asn Val Thr Thr Arg Ile Trp Asn Gly Thr Phe Ala Ser Ser Thr
        1075                1080                1085
Phe Gln Thr Val Gln Leu Thr Ala Ala Ala Glu Ile Asn Thr Tyr Asn
    1090                1095                1100
Pro Glu Ile Tyr Val Ile Glu Asp Asn Thr Val Thr Ile Pro Leu Met
1105                1110                1115                1120
Ile Met Lys Pro Asp Glu Lys Ala Glu Val Pro Thr Gly Val Ile Ile
                1125                1130                1135
Gly Ser Ile Ile Ala Gly Ile Leu Leu Leu Leu Ala Leu Val Ala Ile
            1140                1145                1150
Leu Trp Lys Leu Gly Phe Phe Lys Arg Lys Tyr Glu Lys Met Thr Lys
        1155                1160                1165
Asn Pro Asp Glu Ile Asp Glu Thr Thr Glu Leu Ser Ser
    1170                1175                1180

<210> 284
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 284
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Ser Glu Ile Gly His Ser Pro Pro Pro Ala Tyr
                1045                1050                1055
Thr Pro Met Ser Gly Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala
            1060                1065                1070
Ala Glu Gln Gly Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile
        1075                1080                1085
Pro Glu Ala Pro Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp
    1090                1095                1100
Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln
1105                1110                1115                1120
Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala
                1125                1130                1135
Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr
            1140                1145                1150
Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu
        1155                1160                1165
Asn Pro Phe Val Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp
    1170                1175                1180
Asn Pro Glu Tyr His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp
1185                1190                1195                1200
Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu
                1205                1210                1215
Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys
            1220                1225                1230
Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro
        1235                1240                1245
Pro Arg Ser Thr Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr
    1250                1255                1260
Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu
1265                1270                1275                1280
Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu
                1285                1290                1295
Pro Pro Pro Pro Tyr Arg His Arg Asn Thr Val Val
            1300                1305

<210> 285
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 285
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Ser Glu Ile Gly His Ser Pro Pro Pro Ala Tyr
                1045                1050                1055
Thr Pro Met Ser Gly Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala
            1060                1065                1070
Ala Glu Gln Gly Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile
        1075                1080                1085
Pro Glu Ala Pro Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp
    1090                1095                1100
Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln
1105                1110                1115                1120
Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala
                1125                1130                1135
Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr
            1140                1145                1150
Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu
        1155                1160                1165
Asn Pro Phe Val Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp
    1170                1175                1180
Asn Pro Glu Tyr His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp
1185                1190                1195                1200
Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu
                1205                1210                1215
Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys
            1220                1225                1230
Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro
        1235                1240                1245
Pro Arg Ser Thr Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr
    1250                1255                1260
Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu
1265                1270                1275                1280
Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu
                1285                1290                1295
Pro Pro Pro Pro Tyr Arg His Arg Asn Thr Val Val
            1300                1305

<210> 286
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 286
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Ser Glu Ile Gly His Ser Pro Pro Pro Ala Tyr
                1045                1050                1055
Thr Pro Met Ser Gly Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala
            1060                1065                1070
Ala Glu Gln Gly Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile
        1075                1080                1085
Pro Glu Ala Pro Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp
    1090                1095                1100
Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln
1105                1110                1115                1120
Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala
                1125                1130                1135
Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr
            1140                1145                1150
Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu
        1155                1160                1165
Asn Pro Phe Val Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp
    1170                1175                1180
Asn Pro Glu Tyr His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp
1185                1190                1195                1200
Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu
                1205                1210                1215
Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys
            1220                1225                1230
Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro
        1235                1240                1245
Pro Arg Ser Thr Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr
    1250                1255                1260
Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu
1265                1270                1275                1280
Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu
                1285                1290                1295
Pro Pro Pro Pro Tyr Arg His Arg Asn Thr Val Val
            1300                1305

<210> 287
<211> 1058
<212> PRT
<213> Homo sapiens

<400> 287
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Ser Val Arg Asn Asn Tyr Ile His Ile Ser Tyr
                1045                1050                1055
Ser Phe


<210> 288
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 288
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Ser Glu Ile Gly His Ser Pro Pro Pro Ala Tyr
                1045                1050                1055
Thr Pro Met Ser Gly Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala
            1060                1065                1070
Ala Glu Gln Gly Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile
        1075                1080                1085
Pro Glu Ala Pro Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp
    1090                1095                1100
Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln
1105                1110                1115                1120
Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala
                1125                1130                1135
Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr
            1140                1145                1150
Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu
        1155                1160                1165
Asn Pro Phe Val Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp
    1170                1175                1180
Asn Pro Glu Tyr His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp
1185                1190                1195                1200
Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu
                1205                1210                1215
Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys
            1220                1225                1230
Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro
        1235                1240                1245
Pro Arg Ser Thr Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr
    1250                1255                1260
Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu
1265                1270                1275                1280
Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu
                1285                1290                1295
Pro Pro Pro Pro Tyr Arg His Arg Asn Thr Val Val
            1300                1305

<210> 289
<211> 1058
<212> PRT
<213> Homo sapiens

<400> 289
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Ser Val Arg Asn Asn Tyr Ile His Ile Ser Tyr
                1045                1050                1055
Ser Phe


<210> 290
<211> 910
<212> PRT
<213> Homo sapiens

<400> 290
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Lys Ala Glu Asn Cys Thr
                485                 490                 495
Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys Trp
            500                 505                 510
Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg Gly
        515                 520                 525
Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg Glu
    530                 535                 540
Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu Lys
545                 550                 555                 560
Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn Cys
                565                 570                 575
Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys Cys
            580                 585                 590
Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala Asp
        595                 600                 605
Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly Cys
    610                 615                 620
Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly His
625                 630                 635                 640
Ser Thr Leu Pro Gln Asp Pro Val Lys Val Lys Ala Leu Glu Gly Phe
                645                 650                 655
Pro Arg Leu Val Gly Pro Asp Phe Phe Gly Cys Ala Glu Pro Ala Asn
            660                 665                 670
Thr Phe Leu Asp Pro Glu Glu Pro Lys Ser Cys Asp Lys Thr His Thr
        675                 680                 685
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
    690                 695                 700
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
705                 710                 715                 720
Glu Val Thr Cys Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                725                 730                 735
Phe Asn Gln Tyr Val Asp Gly Val Glu Val His Val Ala Lys Thr Lys
            740                 745                 750
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        755                 760                 765
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    770                 775                 780
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
785                 790                 795                 800
Ala Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
                805                 810                 815
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
            820                 825                 830
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
        835                 840                 845
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
    850                 855                 860
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
865                 870                 875                 880
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
                885                 890                 895
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            900                 905                 910

<210> 291
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 291
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Ile Gly Ser Ser Ile Glu Asp Cys Ile Gly Leu Met Asp Arg Thr
625                 630                 635                 640
Pro Leu Ile Ala Ala Gly Val Ile Gly Gly Leu Phe Ile Leu Val Ile
                645                 650                 655
Val Gly Leu Thr Phe Ala Val Tyr Val Arg Arg Lys Ser Ile Lys Lys
            660                 665                 670
Lys Arg Ala Leu Arg Arg Phe Leu Glu Thr Glu Leu Val Glu Pro Leu
        675                 680                 685
Thr Pro Ser Gly Thr Ala Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys
    690                 695                 700
Glu Thr Glu Leu Lys Arg Val Lys Val Leu Gly Ser Gly Ala Phe Gly
705                 710                 715                 720
Thr Val Tyr Lys Gly Ile Trp Val Pro Glu Gly Glu Thr Val Lys Ile
                725                 730                 735
Pro Val Ala Ile Lys Ile Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn
            740                 745                 750
Val Glu Phe Met Asp Glu Ala Leu Ile Met Ala Ser Met Asp His Pro
        755                 760                 765
His Leu Val Arg Leu Leu Gly Val Cys Leu Ser Pro Thr Ile Gln Leu
    770                 775                 780
Val Thr Gln Leu Met Pro His Gly Cys Leu Leu Glu Tyr Val His Glu
785                 790                 795                 800
His Lys Asp Asn Ile Gly Ser Gln Leu Leu Leu Asn Trp Cys Val Gln
                805                 810                 815
Ile Ala Lys Gly Met Met Tyr Leu Glu Glu Arg Arg Leu Val His Arg
            820                 825                 830
Asp Leu Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys
        835                 840                 845
Ile Thr Asp Phe Gly Leu Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu
    850                 855                 860
Tyr Asn Ala Asp Gly Gly Lys Met Pro Ile Lys Trp Met Ala Leu Glu
865                 870                 875                 880
Cys Ile His Tyr Arg Lys Phe Thr His Gln Ser Asp Val Trp Ser Tyr
                885                 890                 895
Gly Val Thr Ile Trp Glu Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp
            900                 905                 910
Gly Ile Pro Thr Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg
        915                 920                 925
Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Val Met Val
    930                 935                 940
Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu
945                 950                 955                 960
Ala Ala Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Tyr Leu Val
                965                 970                 975
Ile Gln Gly Asp Asp Arg Met Lys Leu Pro Ser Pro Asn Asp Ser Lys
            980                 985                 990
Phe Phe Gln Asn Leu Leu Asp Glu Glu Asp Leu Glu Asp Met Met Asp
        995                 1000                1005
Ala Glu Glu Tyr Leu Val Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile
    1010                1015                1020
Tyr Thr Ser Arg Ala Arg Ile Asp Ser Asn Arg Ser Glu Ile Gly His
1025                1030                1035                1040
Ser Pro Pro Pro Ala Tyr Thr Pro Met Ser Gly Asn Gln Phe Val Tyr
                1045                1050                1055
Arg Asp Gly Gly Phe Ala Ala Glu Gln Gly Val Ser Val Pro Tyr Arg
            1060                1065                1070
Ala Pro Thr Ser Thr Ile Pro Glu Ala Pro Val Ala Gln Gly Ala Thr
        1075                1080                1085
Ala Glu Ile Phe Asp Asp Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro
    1090                1095                1100
Val Ala Pro His Val Gln Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala
1105                1110                1115                1120
Asp Pro Thr Val Phe Ala Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp
                1125                1130                1135
Glu Glu Gly Tyr Met Thr Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr
            1140                1145                1150
Leu Asn Pro Val Glu Glu Asn Pro Phe Val Ser Arg Arg Lys Asn Gly
        1155                1160                1165
Asp Leu Gln Ala Leu Asp Asn Pro Glu Tyr His Asn Ala Ser Asn Gly
    1170                1175                1180
Pro Pro Lys Ala Glu Asp Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn
1185                1190                1195                1200
Thr Phe Ala Asn Thr Leu Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile
                1205                1210                1215
Leu Ser Met Pro Glu Lys Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr
            1220                1225                1230
Trp Asn His Ser Leu Pro Pro Arg Ser Thr Leu Gln His Pro Asp Tyr
        1235                1240                1245
Leu Gln Glu Tyr Ser Thr Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile
    1250                1255                1260
Arg Pro Ile Val Ala Glu Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu
1265                1270                1275                1280
Lys Pro Gly Thr Val Leu Pro Pro Pro Pro Tyr Arg His Arg Asn Thr
                1285                1290                1295
Val Val


<210> 292
<211> 1292
<212> PRT
<213> Homo sapiens

<400> 292
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala
                1045                1050                1055
Ala Glu Gln Gly Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile
            1060                1065                1070
Pro Glu Ala Pro Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp
        1075                1080                1085
Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln
    1090                1095                1100
Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala
1105                1110                1115                1120
Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr
                1125                1130                1135
Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu
            1140                1145                1150
Asn Pro Phe Val Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp
        1155                1160                1165
Asn Pro Glu Tyr His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp
    1170                1175                1180
Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu
1185                1190                1195                1200
Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys
                1205                1210                1215
Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro
            1220                1225                1230
Pro Arg Ser Thr Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr
        1235                1240                1245
Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu
    1250                1255                1260
Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu
1265                1270                1275                1280
Pro Pro Pro Pro Tyr Arg His Arg Asn Thr Val Val
                1285                1290

<210> 293
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 293
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Ser Glu Ile Gly His Ser Pro Pro Pro Ala Tyr
                1045                1050                1055
Thr Pro Met Ser Gly Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala
            1060                1065                1070
Ala Glu Gln Gly Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile
        1075                1080                1085
Pro Glu Ala Pro Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp
    1090                1095                1100
Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln
1105                1110                1115                1120
Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala
                1125                1130                1135
Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr
            1140                1145                1150
Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu
        1155                1160                1165
Asn Pro Phe Val Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp
    1170                1175                1180
Asn Pro Glu Tyr His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp
1185                1190                1195                1200
Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu
                1205                1210                1215
Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys
            1220                1225                1230
Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro
        1235                1240                1245
Pro Arg Ser Thr Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr
    1250                1255                1260
Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu
1265                1270                1275                1280
Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu
                1285                1290                1295
Pro Pro Pro Pro Tyr Arg His Arg Asn Thr Val Val
            1300                1305

<210> 294
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 294
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Ser Glu Ile Gly His Ser Pro Pro Pro Ala Tyr
                1045                1050                1055
Thr Pro Met Ser Gly Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala
            1060                1065                1070
Ala Glu Gln Gly Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile
        1075                1080                1085
Pro Glu Ala Pro Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp
    1090                1095                1100
Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln
1105                1110                1115                1120
Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala
                1125                1130                1135
Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr
            1140                1145                1150
Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu
        1155                1160                1165
Asn Pro Phe Val Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp
    1170                1175                1180
Asn Pro Glu Tyr His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp
1185                1190                1195                1200
Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu
                1205                1210                1215
Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys
            1220                1225                1230
Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro
        1235                1240                1245
Pro Arg Ser Thr Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr
    1250                1255                1260
Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu
1265                1270                1275                1280
Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu
                1285                1290                1295
Pro Pro Pro Pro Tyr Arg His Arg Asn Thr Val Val
            1300                1305

<210> 295
<211> 492
<212> PRT
<213> Homo sapiens

<400> 295
Met Arg Leu Ala Ala Ala Ala Asn Glu Ala Tyr Thr Ala Pro Leu Ala
 1               5                  10                  15
Val Ser Gly Leu Leu Gly Cys Lys Gln Cys Gly Gly Gly Arg Asp Gln
            20                  25                  30
Asp Glu Glu Leu Gly Ile Arg Ile Pro Arg Pro Leu Gly Gln Gly Pro
        35                  40                  45
Ser Arg Phe Ile Pro Glu Lys Glu Ile Leu Gln Val Gly Ser Glu Asp
    50                  55                  60
Ala Gln Met His Ala Leu Phe Ala Asp Ser Phe Ala Ala Leu Gly Arg
65                  70                  75                  80
Leu Asp Asn Ile Thr Leu Val Met Val Phe His Pro Gln Tyr Leu Glu
                85                  90                  95
Ser Phe Leu Lys Thr Gln His Tyr Leu Leu Gln Met Asp Gly Pro Leu
            100                 105                 110
Pro Leu His Tyr Arg His Tyr Ile Gly Ile Met Ala Ala Ala Arg His
        115                 120                 125
Gln Cys Ser Tyr Leu Val Asn Leu His Val Asn Asp Phe Leu His Val
    130                 135                 140
Gly Gly Asp Pro Lys Trp Leu Asn Gly Leu Glu Asn Ala Pro Gln Lys
145                 150                 155                 160
Leu Gln Asn Leu Gly Glu Leu Asn Lys Val Leu Ala His Arg Pro Trp
                165                 170                 175
Leu Ile Thr Lys Glu His Ile Glu Gly Leu Leu Lys Ala Glu Glu His
            180                 185                 190
Ser Trp Ser Leu Ala Glu Leu Val His Ala Val Val Leu Leu Thr His
        195                 200                 205
Tyr His Ser Leu Ala Ser Phe Thr Phe Gly Cys Gly Ile Ser Pro Glu
    210                 215                 220
Ile His Cys Asp Gly Gly His Thr Phe Arg Pro Pro Ser Val Ser Asn
225                 230                 235                 240
Tyr Cys Ile Cys Asp Ile Thr Asn Gly Asn His Ser Val Asp Glu Met
                245                 250                 255
Pro Val Asn Ser Ala Glu Asn Val Ser Val Ser Asp Ser Phe Phe Glu
            260                 265                 270
Val Glu Ala Leu Met Glu Lys Met Arg Gln Leu Gln Glu Cys Arg Asp
        275                 280                 285
Glu Glu Glu Ala Ser Gln Glu Glu Met Ala Ser Arg Phe Glu Ile Glu
    290                 295                 300
Lys Arg Glu Ser Met Phe Val Phe Ser Ser Asp Asp Glu Glu Val Thr
305                 310                 315                 320
Pro Ala Arg Ala Val Ser Arg His Phe Glu Asp Thr Ser Tyr Gly Tyr
                325                 330                 335
Lys Asp Phe Ser Arg His Gly Met His Val Pro Thr Phe Arg Val Gln
            340                 345                 350
Asp Tyr Cys Trp Glu Asp His Gly Tyr Ser Leu Val Asn Arg Leu Tyr
        355                 360                 365
Pro Asp Val Gly Gln Leu Ile Asp Glu Lys Phe His Ile Ala Tyr Asn
    370                 375                 380
Leu Thr Tyr Asn Thr Met Ala Met His Lys Asp Val Asp Thr Ser Met
385                 390                 395                 400
Leu Arg Arg Ala Ile Trp Asn Tyr Ile His Cys Met Phe Gly Ile Arg
                405                 410                 415
Tyr Asp Asp Tyr Asp Tyr Gly Glu Ile Asn Gln Leu Leu Asp Arg Ser
            420                 425                 430
Phe Lys Val Tyr Ile Lys Thr Val Val Cys Thr Pro Glu Lys Val Thr
        435                 440                 445
Lys Arg Met Tyr Asp Ser Phe Trp Arg Gln Phe Lys His Ser Glu Lys
    450                 455                 460
Val His Val Asn Leu Leu Leu Ile Glu Ala Arg Met Gln Ala Glu Leu
465                 470                 475                 480
Leu Tyr Ala Leu Arg Ala Ile Thr Arg Tyr Met Thr
                485                 490

<210> 296
<211> 426
<212> PRT
<213> Homo sapiens

<400> 296
Met His Ala Leu Phe Ala Asp Ser Phe Ala Ala Leu Gly Arg Leu Asp
 1               5                  10                  15
Asn Ile Thr Leu Val Met Val Phe His Pro Gln Tyr Leu Glu Ser Phe
            20                  25                  30
Leu Lys Thr Gln His Tyr Leu Leu Gln Met Asp Gly Pro Leu Pro Leu
        35                  40                  45
His Tyr Arg His Tyr Ile Gly Ile Met Ala Ala Ala Arg His Gln Cys
    50                  55                  60
Ser Tyr Leu Val Asn Leu His Val Asn Asp Phe Leu His Val Gly Gly
65                  70                  75                  80
Asp Pro Lys Trp Leu Asn Gly Leu Glu Asn Ala Pro Gln Lys Leu Gln
                85                  90                  95
Asn Leu Gly Glu Leu Asn Lys Val Leu Ala His Arg Pro Trp Leu Ile
            100                 105                 110
Thr Lys Glu His Ile Glu Gly Leu Leu Lys Ala Glu Glu His Ser Trp
        115                 120                 125
Ser Leu Ala Glu Leu Val His Ala Val Val Leu Leu Thr His Tyr His
    130                 135                 140
Ser Leu Ala Ser Phe Thr Phe Gly Cys Gly Ile Ser Pro Glu Ile His
145                 150                 155                 160
Cys Asp Gly Gly His Thr Phe Arg Pro Pro Ser Val Ser Asn Tyr Cys
                165                 170                 175
Ile Cys Asp Ile Thr Asn Gly Asn His Ser Val Asp Glu Met Pro Val
            180                 185                 190
Asn Ser Ala Glu Asn Val Ser Val Ser Asp Ser Phe Phe Glu Val Glu
        195                 200                 205
Ala Leu Met Glu Lys Met Arg Gln Leu Gln Glu Cys Arg Asp Glu Glu
    210                 215                 220
Glu Ala Ser Gln Glu Glu Met Ala Ser Arg Phe Glu Ile Glu Lys Arg
225                 230                 235                 240
Glu Ser Met Phe Val Phe Ser Ser Asp Asp Glu Glu Val Thr Pro Ala
                245                 250                 255
Arg Ala Val Ser Arg His Phe Glu Asp Thr Ser Tyr Gly Tyr Lys Asp
            260                 265                 270
Phe Ser Arg His Gly Met His Val Pro Thr Phe Arg Val Gln Asp Tyr
        275                 280                 285
Cys Trp Glu Asp His Gly Tyr Ser Leu Val Asn Arg Leu Tyr Pro Asp
    290                 295                 300
Val Gly Gln Leu Ile Asp Glu Lys Phe His Ile Ala Tyr Asn Leu Thr
305                 310                 315                 320
Tyr Asn Thr Met Ala Met His Lys Asp Val Asp Thr Ser Met Leu Arg
                325                 330                 335
Arg Ala Ile Trp Asn Tyr Ile His Cys Met Phe Gly Ile Arg Tyr Asp
            340                 345                 350
Asp Tyr Asp Tyr Gly Glu Ile Asn Gln Leu Leu Asp Arg Ser Phe Lys
        355                 360                 365
Val Tyr Ile Lys Thr Val Val Cys Thr Pro Glu Lys Val Thr Lys Arg
    370                 375                 380
Met Tyr Asp Ser Phe Trp Arg Gln Phe Lys His Ser Glu Lys Val His
385                 390                 395                 400
Val Asn Leu Leu Leu Ile Glu Ala Arg Met Gln Ala Glu Leu Leu Tyr
                405                 410                 415
Ala Leu Arg Ala Ile Thr Arg Tyr Met Thr
            420                 425

<210> 297
<211> 551
<212> PRT
<213> Homo sapiens

<400> 297
Met Ala Glu Gly Glu Asn Glu Val Arg Trp Asp Gly Leu Cys Ser Arg
 1               5                  10                  15
Asp Ser Thr Thr Arg Glu Thr Ala Leu Glu Asn Ile Arg Gln Thr Ile
            20                  25                  30
Leu Arg Lys Thr Glu Tyr Leu Arg Ser Val Lys Glu Thr Pro His Arg
        35                  40                  45
Pro Ser Asp Gly Leu Ser Asn Thr Glu Ser Ser Asp Gly Leu Asn Lys
    50                  55                  60
Leu Leu Ala His Leu Leu Met Leu Ser Lys Arg Cys Pro Phe Lys Asp
65                  70                  75                  80
Val Arg Glu Lys Ser Glu Phe Ile Leu Lys Ser Ile Gln Glu Leu Gly
                85                  90                  95
Ile Arg Ile Pro Arg Pro Leu Gly Gln Gly Pro Ser Arg Phe Ile Pro
            100                 105                 110
Glu Lys Glu Ile Leu Gln Val Gly Ser Glu Asp Ala Gln Met His Ala
        115                 120                 125
Leu Phe Ala Asp Ser Phe Ala Ala Leu Gly Arg Leu Asp Asn Ile Thr
    130                 135                 140
Leu Val Met Val Phe His Pro Gln Tyr Leu Glu Ser Phe Leu Lys Thr
145                 150                 155                 160
Gln His Tyr Leu Leu Gln Met Asp Gly Pro Leu Pro Leu His Tyr Arg
                165                 170                 175
His Tyr Ile Gly Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu
            180                 185                 190
Val Asn Leu His Val Asn Asp Phe Leu His Val Gly Gly Asp Pro Lys
        195                 200                 205
Trp Leu Asn Gly Leu Glu Asn Ala Pro Gln Lys Leu Gln Asn Leu Gly
    210                 215                 220
Glu Leu Asn Lys Val Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu
225                 230                 235                 240
His Ile Glu Gly Leu Leu Lys Ala Glu Glu His Ser Trp Ser Leu Ala
                245                 250                 255
Glu Leu Val His Ala Val Val Leu Leu Thr His Tyr His Ser Leu Ala
            260                 265                 270
Ser Phe Thr Phe Gly Cys Gly Ile Ser Pro Glu Ile His Cys Asp Gly
        275                 280                 285
Gly His Thr Phe Arg Pro Pro Ser Val Ser Asn Tyr Cys Ile Cys Asp
    290                 295                 300
Ile Thr Asn Gly Asn His Ser Val Asp Glu Met Pro Val Asn Ser Ala
305                 310                 315                 320
Glu Asn Val Ser Val Ser Asp Ser Phe Phe Glu Val Glu Ala Leu Met
                325                 330                 335
Glu Lys Met Arg Gln Leu Gln Glu Cys Arg Asp Glu Glu Glu Ala Ser
            340                 345                 350
Gln Glu Glu Met Ala Ser Arg Phe Glu Ile Glu Lys Arg Glu Ser Met
        355                 360                 365
Phe Val Phe Ser Ser Asp Asp Glu Glu Val Thr Pro Ala Arg Ala Val
    370                 375                 380
Ser Arg His Phe Glu Asp Thr Ser Tyr Gly Tyr Lys Asp Phe Ser Arg
385                 390                 395                 400
His Gly Met His Val Pro Thr Phe Arg Val Gln Asp Tyr Cys Trp Glu
                405                 410                 415
Asp His Gly Tyr Ser Leu Val Asn Arg Leu Tyr Pro Asp Val Gly Gln
            420                 425                 430
Leu Ile Asp Glu Lys Phe His Ile Ala Tyr Asn Leu Thr Tyr Asn Thr
        435                 440                 445
Met Ala Met His Lys Asp Val Asp Thr Ser Met Leu Arg Arg Ala Ile
    450                 455                 460
Trp Asn Tyr Ile His Cys Met Phe Gly Ile Arg Tyr Asp Asp Tyr Asp
465                 470                 475                 480
Tyr Gly Glu Ile Asn Gln Leu Leu Asp Arg Ser Phe Lys Val Tyr Ile
                485                 490                 495
Lys Thr Val Val Cys Thr Pro Glu Lys Val Thr Lys Arg Met Tyr Asp
            500                 505                 510
Ser Phe Trp Arg Gln Phe Lys His Ser Glu Lys Val His Val Asn Leu
        515                 520                 525
Leu Leu Ile Glu Ala Arg Met Gln Ala Glu Leu Leu Tyr Ala Leu Arg
    530                 535                 540
Ala Ile Thr Arg Tyr Met Thr
545                 550

<210> 298
<211> 551
<212> PRT
<213> Homo sapiens

<400> 298
Met Ala Glu Gly Glu Asn Glu Val Arg Trp Asp Gly Leu Cys Ser Arg
 1               5                  10                  15
Asp Ser Thr Thr Arg Glu Thr Ala Leu Glu Asn Ile Arg Gln Thr Ile
            20                  25                  30
Leu Arg Lys Thr Glu Tyr Leu Arg Ser Val Lys Glu Thr Pro His Arg
        35                  40                  45
Pro Ser Asp Gly Leu Ser Asn Thr Glu Ser Ser Asp Gly Leu Asn Lys
    50                  55                  60
Leu Leu Ala His Leu Leu Met Leu Ser Lys Arg Cys Pro Phe Lys Asp
65                  70                  75                  80
Val Arg Glu Lys Ser Glu Phe Ile Leu Lys Ser Ile Gln Glu Leu Gly
                85                  90                  95
Ile Arg Ile Pro Arg Pro Leu Gly Gln Gly Pro Ser Arg Phe Ile Pro
            100                 105                 110
Glu Lys Glu Ile Leu Gln Val Gly Ser Glu Asp Ala Gln Met His Ala
        115                 120                 125
Leu Phe Ala Asp Ser Phe Ala Ala Leu Gly Arg Leu Asp Asn Ile Thr
    130                 135                 140
Leu Val Met Val Phe His Pro Gln Tyr Leu Glu Ser Phe Leu Lys Thr
145                 150                 155                 160
Gln His Tyr Leu Leu Gln Met Asp Gly Pro Leu Pro Leu His Tyr Arg
                165                 170                 175
His Tyr Ile Gly Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu
            180                 185                 190
Val Asn Leu His Val Asn Asp Phe Leu His Val Gly Gly Asp Pro Lys
        195                 200                 205
Trp Leu Asn Gly Leu Glu Asn Ala Pro Gln Lys Leu Gln Asn Leu Gly
    210                 215                 220
Glu Leu Asn Lys Val Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu
225                 230                 235                 240
His Ile Glu Gly Leu Leu Lys Ala Glu Glu His Ser Trp Ser Leu Ala
                245                 250                 255
Glu Leu Val His Ala Val Val Leu Leu Thr His Tyr His Ser Leu Ala
            260                 265                 270
Ser Phe Thr Phe Gly Cys Gly Ile Ser Pro Glu Ile His Cys Asp Gly
        275                 280                 285
Gly His Thr Phe Arg Pro Pro Ser Val Ser Asn Tyr Cys Ile Cys Asp
    290                 295                 300
Ile Thr Asn Gly Asn His Ser Val Asp Glu Met Pro Val Asn Ser Ala
305                 310                 315                 320
Glu Asn Val Ser Val Ser Asp Ser Phe Phe Glu Val Glu Ala Leu Met
                325                 330                 335
Glu Lys Met Arg Gln Leu Gln Glu Cys Arg Asp Glu Glu Glu Ala Ser
            340                 345                 350
Gln Glu Glu Met Ala Ser Arg Phe Glu Ile Glu Lys Arg Glu Ser Met
        355                 360                 365
Phe Val Phe Ser Ser Asp Asp Glu Glu Val Thr Pro Ala Arg Ala Val
    370                 375                 380
Ser Arg His Phe Glu Asp Thr Ser Tyr Gly Tyr Lys Asp Phe Ser Arg
385                 390                 395                 400
His Gly Met His Val Pro Thr Phe Arg Val Gln Asp Tyr Cys Trp Glu
                405                 410                 415
Asp His Gly Tyr Ser Leu Val Asn Arg Leu Tyr Pro Asp Val Gly Gln
            420                 425                 430
Leu Ile Asp Glu Lys Phe His Ile Ala Tyr Asn Leu Thr Tyr Asn Thr
        435                 440                 445
Met Ala Met His Lys Asp Val Asp Thr Ser Met Leu Arg Arg Ala Ile
    450                 455                 460
Trp Asn Tyr Ile His Cys Met Phe Gly Ile Arg Tyr Asp Asp Tyr Asp
465                 470                 475                 480
Tyr Gly Glu Ile Asn Gln Leu Leu Asp Arg Ser Phe Lys Val Tyr Ile
                485                 490                 495
Lys Thr Val Val Cys Thr Pro Glu Lys Val Thr Lys Arg Met Tyr Asp
            500                 505                 510
Ser Phe Trp Arg Gln Phe Lys His Ser Glu Lys Val His Val Asn Leu
        515                 520                 525
Leu Leu Ile Glu Ala Arg Met Gln Ala Glu Leu Leu Tyr Ala Leu Arg
    530                 535                 540
Ala Ile Thr Arg Tyr Met Thr
545                 550

<210> 299
<211> 492
<212> PRT
<213> Homo sapiens

<400> 299
Met Arg Leu Ala Ala Ala Ala Asn Glu Ala Tyr Thr Ala Pro Leu Ala
 1               5                  10                  15
Val Ser Gly Leu Leu Gly Cys Lys Gln Cys Gly Gly Gly Arg Asp Gln
            20                  25                  30
Asp Glu Glu Leu Gly Ile Arg Ile Pro Arg Pro Leu Gly Gln Gly Pro
        35                  40                  45
Ser Arg Phe Ile Pro Glu Lys Glu Ile Leu Gln Val Gly Ser Glu Asp
    50                  55                  60
Ala Gln Met His Ala Leu Phe Ala Asp Ser Phe Ala Ala Leu Gly Arg
65                  70                  75                  80
Leu Asp Asn Ile Thr Leu Val Met Val Phe His Pro Gln Tyr Leu Glu
                85                  90                  95
Ser Phe Leu Lys Thr Gln His Tyr Leu Leu Gln Met Asp Gly Pro Leu
            100                 105                 110
Pro Leu His Tyr Arg His Tyr Ile Gly Ile Met Ala Ala Ala Arg His
        115                 120                 125
Gln Cys Ser Tyr Leu Val Asn Leu His Val Asn Asp Phe Leu His Val
    130                 135                 140
Gly Gly Asp Pro Lys Trp Leu Asn Gly Leu Glu Asn Ala Pro Gln Lys
145                 150                 155                 160
Leu Gln Asn Leu Gly Glu Leu Asn Lys Val Leu Ala His Arg Pro Trp
                165                 170                 175
Leu Ile Thr Lys Glu His Ile Glu Gly Leu Leu Lys Ala Glu Glu His
            180                 185                 190
Ser Trp Ser Leu Ala Glu Leu Val His Ala Val Val Leu Leu Thr His
        195                 200                 205
Tyr His Ser Leu Ala Ser Phe Thr Phe Gly Cys Gly Ile Ser Pro Glu
    210                 215                 220
Ile His Cys Asp Gly Gly His Thr Phe Arg Pro Pro Ser Val Ser Asn
225                 230                 235                 240
Tyr Cys Ile Cys Asp Ile Thr Asn Gly Asn His Ser Val Asp Glu Met
                245                 250                 255
Pro Val Asn Ser Ala Glu Asn Val Ser Val Ser Asp Ser Phe Phe Glu
            260                 265                 270
Val Glu Ala Leu Met Glu Lys Met Arg Gln Leu Gln Glu Cys Arg Asp
        275                 280                 285
Glu Glu Glu Ala Ser Gln Glu Glu Met Ala Ser Arg Phe Glu Ile Glu
    290                 295                 300
Lys Arg Glu Ser Met Phe Val Phe Ser Ser Asp Asp Glu Glu Val Thr
305                 310                 315                 320
Pro Ala Arg Ala Val Ser Arg His Phe Glu Asp Thr Ser Tyr Gly Tyr
                325                 330                 335
Lys Asp Phe Ser Arg His Gly Met His Val Pro Thr Phe Arg Val Gln
            340                 345                 350
Asp Tyr Cys Trp Glu Asp His Gly Tyr Ser Leu Val Asn Arg Leu Tyr
        355                 360                 365
Pro Asp Val Gly Gln Leu Ile Asp Glu Lys Phe His Ile Ala Tyr Asn
    370                 375                 380
Leu Thr Tyr Asn Thr Met Ala Met His Lys Asp Val Asp Thr Ser Met
385                 390                 395                 400
Leu Arg Arg Ala Ile Trp Asn Tyr Ile His Cys Met Phe Gly Ile Arg
                405                 410                 415
Tyr Asp Asp Tyr Asp Tyr Gly Glu Ile Asn Gln Leu Leu Asp Arg Ser
            420                 425                 430
Phe Lys Val Tyr Ile Lys Thr Val Val Cys Thr Pro Glu Lys Val Thr
        435                 440                 445
Lys Arg Met Tyr Asp Ser Phe Trp Arg Gln Phe Lys His Ser Glu Lys
    450                 455                 460
Val His Val Asn Leu Leu Leu Ile Glu Ala Arg Met Gln Ala Glu Leu
465                 470                 475                 480
Leu Tyr Ala Leu Arg Ala Ile Thr Arg Tyr Met Thr
                485                 490

<210> 300
<211> 289
<212> PRT
<213> Homo sapiens

<400> 300
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240
Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn
                245                 250                 255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu
            260                 265                 270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp
        275                 280                 285
Leu


<210> 301
<211> 289
<212> PRT
<213> Homo sapiens

<400> 301
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240
Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn
                245                 250                 255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu
            260                 265                 270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp
        275                 280                 285
Leu


<210> 302
<211> 240
<212> PRT
<213> Homo sapiens

<400> 302
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Asn Val Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu His
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240

<210> 303
<211> 289
<212> PRT
<213> Homo sapiens

<400> 303
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240
Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn
                245                 250                 255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu
            260                 265                 270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp
        275                 280                 285
Leu


<210> 304
<211> 289
<212> PRT
<213> Homo sapiens

<400> 304
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240
Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn
                245                 250                 255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu
            260                 265                 270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp
        275                 280                 285
Leu


<210> 305
<211> 289
<212> PRT
<213> Homo sapiens

<400> 305
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240
Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn
                245                 250                 255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu
            260                 265                 270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp
        275                 280                 285
Leu


<210> 306
<211> 271
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(271)
<223> Xaa = Any Amino Acid

<400> 306
Met Gln Leu Leu Gly Cys Glu Val Asp Pro Val Leu Arg Ala Thr Arg
 1               5                  10                  15
Asp Cys Asn Leu Leu Gln Val Asp Arg Val Leu Lys Asn Leu Leu Ala
            20                  25                  30
Ile Lys Lys Arg Tyr Leu Gln Xaa Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Ala Ile Gln Pro Tyr Met His Arg Met Val Pro Leu Leu Met Val
    50                  55                  60
Met Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Lys Val Phe Pro
65                  70                  75                  80
Leu Ala Thr Ile Tyr Leu Asp Cys Phe Phe Ala Arg Ile Pro Thr Ser
                85                  90                  95
Lys Ser His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser
            100                 105                 110
Arg Leu Lys Glu Ser Ser Pro Leu Thr Ala Lys Lys Leu Cys Ile Tyr
        115                 120                 125
Thr Asp Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val
    130                 135                 140
Val Leu Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp
145                 150                 155                 160
Phe Ile Xaa Tyr Ile Leu His Lys Leu Pro Gln Gln Arg Glu Lys Leu
                165                 170                 175
Ser Ala Met Tyr Pro Pro Ser Met Val Ala Thr Gly Ser Val Gly Ala
            180                 185                 190
Ala Ile Cys Gly Leu Gln Gln His Glu Glu Val Ser Ser Leu Pro Cys
        195                 200                 205
Asn Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val Asp
    210                 215                 220
Cys Leu Lys Ala Asn Arg Glu His Ile Glu Val Val Phe Leu Asn Ser
225                 230                 235                 240
Leu Gln Gln Cys His Gln Asp Gln Gln Asp Arg Ser Lys Ser Glu Asp
                245                 250                 255
Glu Leu Gly Gln Xaa Thr Pro Ile Asp Leu Xaa Asp Ile Asp Leu
            260                 265                 270

<210> 307
<211> 289
<212> PRT
<213> Homo sapiens

<400> 307
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Gly Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240
Asp Cys Leu Lys Ala Cys Gln Asp Gln Ile Glu Ala Val Leu Leu Asn
                245                 250                 255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu
            260                 265                 270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp
        275                 280                 285
Leu


<210> 308
<211> 269
<212> PRT
<213> Homo sapiens

<400> 308
Met Gln Leu Leu Gly Cys Glu Val Asp Pro Val Leu Arg Ala Thr Arg
 1               5                  10                  15
Asp Cys Asn Leu Leu Gln Val Asp Arg Val Leu Lys Asn Leu Leu Ala
            20                  25                  30
Ile Lys Lys Arg Tyr Leu Gln Cys Ser Tyr Phe Lys Cys Val Gln Lys
        35                  40                  45
Ala Ile Gln Pro Tyr Met His Arg Met Val Pro Leu Leu Met Val Met
    50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Lys Val Phe Pro Leu
65                  70                  75                  80
Ala Thr Ile Tyr Leu Asp Cys Phe Phe Ala Arg Ile Pro Thr Ser Lys
                85                  90                  95
Ser His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Arg
            100                 105                 110
Leu Lys Glu Ser Ser Pro Leu Thr Ala Lys Lys Leu Cys Ile Tyr Thr
        115                 120                 125
Asp Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Gln Glu Leu Val Val
    130                 135                 140
Leu Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe
145                 150                 155                 160
Ile Tyr Ile Leu His Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Ala
                165                 170                 175
Met Tyr Pro Pro Ser Met Val Ala Thr Gly Ser Val Gly Ala Ala Ile
            180                 185                 190
Cys Gly Leu Gln Gln His Glu Glu Val Ser Ser Leu Pro Cys Asn Ala
        195                 200                 205
Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val Asp Cys Leu
    210                 215                 220
Lys Ala Asn Arg Glu His Ile Glu Val Val Phe Leu Asn Ser Leu Gln
225                 230                 235                 240
Gln Cys His Gln Asp Gln Gln Asp Arg Ser Lys Ser Glu Asp Glu Leu
                245                 250                 255
Gly Gln Ala Ser Thr Pro Ile Asp Leu Asp Ile Asp Leu
            260                 265

<210> 309
<211> 289
<212> PRT
<213> Homo sapiens

<400> 309
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240
Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn
                245                 250                 255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu
            260                 265                 270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp
        275                 280                 285
Leu


<210> 310
<211> 289
<212> PRT
<213> Homo sapiens

<400> 310
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240
Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn
                245                 250                 255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu
            260                 265                 270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp
        275                 280                 285
Leu


<210> 311
<211> 289
<212> PRT
<213> Homo sapiens

<400> 311
Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg
 1               5                  10                  15
Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr
            20                  25                  30
Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln
        35                  40                  45
Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu
    50                  55                  60
Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala
65                  70                  75                  80
Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser
                85                  90                  95
His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu
            100                 105                 110
Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp
        115                 120                 125
Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu
    130                 135                 140
Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile
145                 150                 155                 160
Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu
                165                 170                 175
Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe
            180                 185                 190
Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly
        195                 200                 205
Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr
    210                 215                 220
Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val
225                 230                 235                 240
Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn
                245                 250                 255
Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu
            260                 265                 270
Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp
        275                 280                 285
Leu


<210> 312
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 312
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu Gln Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Ser Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Tyr His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Arg Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Ile Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 313
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 313
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu Gln Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Ser Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Tyr His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Arg Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Ile Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 314
<211> 574
<212> PRT
<213> Homo sapiens

<400> 314
Lys Lys Met Glu Glu Val Lys Glu Ala Asn Ile Arg Val Val Ser Glu
 1               5                  10                  15
Asp Phe Leu Gln Asp Val Ser Ala Ser Thr Lys Ser Leu Gln Glu Leu
            20                  25                  30
Phe Leu Ala His Ile Leu Ser Pro Trp Gly Ala Glu Val Lys Ala Glu
        35                  40                  45
Pro Val Glu Val Val Ala Pro Arg Gly Lys Ser Gly Ala Ala Leu Ser
    50                  55                  60
Lys Lys Ser Lys Gly Gln Val Lys Glu Glu Gly Ile Asn Lys Ser Glu
65                  70                  75                  80
Lys Arg Met Lys Leu Thr Leu Lys Gly Gly Ala Ala Val Asp Pro Asp
                85                  90                  95
Ser Gly Leu Glu His Ser Ala His Val Leu Glu Lys Gly Gly Lys Val
            100                 105                 110
Phe Ser Ala Thr Leu Gly Leu Val Asp Ile Val Lys Gly Thr Asn Ser
        115                 120                 125
Tyr Tyr Lys Leu Gln Leu Leu Glu Asp Asp Lys Glu Asn Arg Tyr Trp
    130                 135                 140
Ile Phe Arg Ser Trp Gly Arg Val Gly Thr Val Ile Gly Ser Asn Lys
145                 150                 155                 160
Leu Glu Gln Met Pro Ser Lys Glu Asp Ala Asn Glu His Phe Met Lys
                165                 170                 175
Leu Tyr Glu Glu Lys Thr Gly Asn Ala Trp His Ser Lys Asn Phe Thr
            180                 185                 190
Lys Tyr Pro Lys Lys Phe Tyr Pro Leu Glu Ile Asp Tyr Gly Gln Asp
        195                 200                 205
Glu Glu Ala Val Lys Lys Leu Thr Val Asn Pro Gly Thr Lys Ser Lys
    210                 215                 220
Leu Pro Lys Pro Val Gln Asp Leu Ile Lys Met Ile Phe Asp Val Glu
225                 230                 235                 240
Ser Met Lys Lys Ala Met Val Glu Tyr Glu Ile Asp Leu Gln Lys Met
                245                 250                 255
Pro Leu Gly Lys Leu Ser Lys Arg Gln Ile Gln Ala Ala Tyr Ser Ile
            260                 265                 270
Leu Ser Glu Val Gln Gln Ala Val Ser Gln Gly Ser Ser Asp Ser Gln
        275                 280                 285
Ile Leu Asp Leu Ser Asn Arg Phe Tyr Thr Leu Ile Pro His Asp Phe
    290                 295                 300
Gly Met Lys Lys Pro Pro Leu Leu Asn Asn Ala Asp Ser Val Gln Ala
305                 310                 315                 320
Lys Val Glu Met Leu Asp Asn Leu Leu Asp Ile Glu Val Ala Tyr Ser
                325                 330                 335
Leu Leu Arg Gly Gly Ser Asp Asp Ser Ser Lys Asp Pro Ile Asp Val
            340                 345                 350
Asn Tyr Glu Lys Leu Lys Thr Asp Ile Lys Val Val Asp Arg Asp Ser
        355                 360                 365
Glu Glu Ala Glu Ile Ile Arg Lys Tyr Val Lys Asn Thr His Ala Thr
    370                 375                 380
Thr His Asn Ala Tyr Asp Leu Glu Val Ile Asp Ile Phe Lys Ile Glu
385                 390                 395                 400
Arg Glu Gly Glu Cys Gln Arg Tyr Lys Pro Phe Lys Gln Leu His Asn
                405                 410                 415
Arg Arg Leu Leu Trp His Gly Ser Arg Thr Thr Asn Phe Ala Gly Ile
            420                 425                 430
Leu Ser Gln Gly Leu Arg Ile Ala Pro Pro Glu Ala Pro Val Thr Gly
        435                 440                 445
Tyr Met Phe Gly Lys Gly Ile Tyr Phe Ala Asp Met Val Ser Lys Ser
    450                 455                 460
Ala Asn Tyr Cys His Thr Ser Gln Gly Asp Pro Ile Gly Leu Ile Leu
465                 470                 475                 480
Leu Gly Glu Val Ala Leu Gly Asn Met Tyr Glu Leu Lys His Ala Ser
                485                 490                 495
His Ile Ser Lys Leu Pro Lys Gly Lys His Ser Val Lys Gly Leu Gly
            500                 505                 510
Lys Thr Thr Pro Asp Pro Ser Ala Asn Ile Ser Leu Asp Gly Val Asp
        515                 520                 525
Val Pro Leu Gly Thr Gly Ile Ser Ser Gly Val Asn Asp Thr Ser Leu
    530                 535                 540
Leu Tyr Asn Glu Tyr Ile Val Tyr Asp Ile Ala Gln Val Asn Leu Lys
545                 550                 555                 560
Tyr Leu Leu Lys Leu Lys Phe Asn Phe Lys Thr Ser Leu Trp
                565                 570

<210> 315
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 315
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 316
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 316
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Gln Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 317
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 317
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu Gln Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Ser Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Tyr His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Arg Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Ile Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 318
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 318
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Glu Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Lys Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 319
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 319
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu Gln Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Ser Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Tyr His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Arg Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Ile Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 320
<211> 1013
<212> PRT
<213> Homo sapiens

<400> 320
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Glu Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Lys Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Arg Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala His Pro
        355                 360                 365
Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala Ser
    370                 375                 380
Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys Leu
385                 390                 395                 400
Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly Gly
                405                 410                 415
Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr Lys
            420                 425                 430
Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu Ala
        435                 440                 445
Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala Ser
    450                 455                 460
Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro Trp
465                 470                 475                 480
Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg Gly
                485                 490                 495
Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys Glu
            500                 505                 510
Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys Gly
        515                 520                 525
Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His Val
    530                 535                 540
Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val Asp
545                 550                 555                 560
Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu Asp
                565                 570                 575
Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val Gly
            580                 585                 590
Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu Asp
        595                 600                 605
Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn Ala
    610                 615                 620
Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro Leu
625                 630                 635                 640
Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr Val
                645                 650                 655
Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu Ile
            660                 665                 670
Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu Tyr
        675                 680                 685
Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg Gln
    690                 695                 700
Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val Ser
705                 710                 715                 720
Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe Tyr
                725                 730                 735
Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu Asn
            740                 745                 750
Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu Leu
        755                 760                 765
Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp Ser
    770                 775                 780
Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp Ile
785                 790                 795                 800
Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys Tyr
                805                 810                 815
Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu Val
            820                 825                 830
Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr Lys
        835                 840                 845
Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser Arg
    850                 855                 860
Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala Pro
865                 870                 875                 880
Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr Phe
                885                 890                 895
Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln Gly
            900                 905                 910
Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn Met
        915                 920                 925
Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly Lys
    930                 935                 940
His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala Asn
945                 950                 955                 960
Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser Ser
                965                 970                 975
Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr Asp
            980                 985                 990
Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn Phe
        995                 1000                1005
Lys Thr Ser Leu Trp
    1010

<210> 321
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 321
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu Gln Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Ser Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Tyr His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Arg Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Ile Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 322
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 322
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Gln Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Thr Ser
                965                 970                 975
Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Thr Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 323
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 323
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Glu Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ala Gly Gln Leu Val Phe
    290                 295                 300
Lys Glu Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ala Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Glu Ala Thr Leu Pro Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ala Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gly Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ala Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Asn Lys Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Glu
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ala Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gln Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 324
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 324
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu Gln Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Ser Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Tyr His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Arg Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Ile Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 325
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 325
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605
Asp Ala Ile Glu Gln Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815
Tyr Val Lys Asn Thr His Ala Thr Thr His Ser Ala Tyr Asp Leu Glu
            820                 825                 830
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Tyr His Thr Ser Gln
            900                 905                 910
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Arg Leu Pro Lys Gly
    930                 935                 940
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975
Ser Gly Val Ile Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005
Phe Lys Thr Ser Leu Trp
    1010

<210> 326
<211> 1013
<212> PRT
<213> Homo sapiens

<400> 326
Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser Gly
 1               5                  10                  15
Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser Leu
            20                  25                  30
Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val Pro
        35                  40                  45
His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile Arg
    50                  55                  60
His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp Asp
65                  70                  75                  80
Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly Lys
                85                  90                  95
Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp Phe
            100                 105                 110
Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys Met
        115                 120                 125
Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val Asp
    130                 135                 140
Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro Gly
145                 150                 155                 160
Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr Ser
                165                 170                 175
Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys Glu
            180                 185                 190
Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg Lys
        195                 200                 205
Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser Lys
    210                 215                 220
Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala Gln
225                 230                 235                 240
Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys Ser
                245                 250                 255
Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val Pro
            260                 265                 270
Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val Phe
        275                 280                 285
Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe Lys
    290                 295                 300
Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys Cys
305                 310                 315                 320
Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro Lys
                325                 330                 335
Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys Gln
            340                 345                 350
Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr Pro
        355                 360                 365
Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala Ser
    370                 375                 380
Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys Leu
385                 390                 395                 400
Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly Gly
                405                 410                 415
Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr Lys
            420                 425                 430
Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu Ala
        435                 440                 445
Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala Ser
    450                 455                 460
Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro Trp
465                 470                 475                 480
Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg Gly
                485                 490                 495
Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys Glu
            500                 505                 510
Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys Gly
        515                 520                 525
Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His Val
    530                 535                 540
Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val Asp
545                 550                 555                 560
Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu Asp
                565                 570                 575
Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val Gly
            580                 585                 590
Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu Asp
        595                 600                 605
Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn Ala
    610                 615                 620
Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro Leu
625                 630                 635                 640
Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr Val
                645                 650                 655
Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu Ile
            660                 665                 670
Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu Tyr
        675                 680                 685
Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg Gln
    690                 695                 700
Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val Ser
705                 710                 715                 720
Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe Tyr
                725                 730                 735
Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu Asn
            740                 745                 750
Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu Leu
        755                 760                 765
Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp Ser
    770                 775                 780
Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp Ile
785                 790                 795                 800
Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys Tyr
                805                 810                 815
Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu Val
            820                 825                 830
Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr Lys
        835                 840                 845
Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser Arg
    850                 855                 860
Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala Pro
865                 870                 875                 880
Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr Phe
                885                 890                 895
Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln Gly
            900                 905                 910
Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn Met
        915                 920                 925
Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly Lys
    930                 935                 940
His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala Asn
945                 950                 955                 960
Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser Ser
                965                 970                 975
Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr Asp
            980                 985                 990
Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn Phe
        995                 1000                1005
Lys Thr Ser Leu Trp
    1010

<210> 327
<211> 255
<212> PRT
<213> Homo sapiens

<400> 327
Met Ala Glu Leu Arg Val Leu Val Ala Val Lys Arg Val Ile Asp Tyr
 1               5                  10                  15
Ala Val Lys Ile Arg Val Lys Pro Asp Arg Thr Gly Val Val Thr Asp
            20                  25                  30
Gly Val Lys His Ser Met Asn Pro Phe Cys Glu Ile Ala Val Glu Glu
        35                  40                  45
Ala Val Arg Leu Lys Glu Lys Lys Leu Val Lys Glu Val Ile Ala Val
    50                  55                  60
Ser Cys Gly Pro Ala Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala
65                  70                  75                  80
Met Gly Ala Asp Arg Gly Ile His Val Glu Val Pro Pro Ala Glu Ala
                85                  90                  95
Glu Arg Leu Gly Pro Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala
            100                 105                 110
Glu Lys Glu Lys Val Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp
        115                 120                 125
Asp Asp Cys Asn Gln Thr Gly Gln Met Thr Ala Gly Phe Leu Asp Trp
    130                 135                 140
Pro Gln Gly Thr Phe Ala Ser Gln Val Thr Leu Glu Gly Asp Lys Leu
145                 150                 155                 160
Lys Val Glu Arg Glu Ile Asp Gly Gly Leu Glu Thr Leu Arg Leu Lys
                165                 170                 175
Leu Pro Ala Val Val Thr Ala Asp Leu Arg Leu Asn Glu Pro Arg Tyr
            180                 185                 190
Ala Thr Leu Pro Asn Ile Met Lys Ala Lys Lys Lys Lys Ile Glu Val
        195                 200                 205
Ile Lys Pro Gly Asp Leu Gly Val Asp Leu Thr Ser Lys Leu Ser Val
    210                 215                 220
Ile Ser Val Glu Asp Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu
225                 230                 235                 240
Thr Thr Glu Asp Leu Val Ala Lys Leu Lys Glu Ile Gly Arg Ile
                245                 250                 255

<210> 328
<211> 283
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(283)
<223> Xaa = Any Amino Acid

<400> 328
Gly Arg Gly Gly Arg Gly Trp Trp Gly Phe Trp Thr Glu Pro Leu Arg
 1               5                  10                  15
Val Arg Ala Asp Pro Val Ser Gly Cys Gly Gly Lys Met Ala Glu Leu
            20                  25                  30
Arg Val Leu Val Ala Val Lys Arg Val Ile Asp Tyr Ala Val Lys Ile
        35                  40                  45
Arg Val Lys Pro Asp Arg Thr Gly Val Val Thr Asp Gly Val Lys His
    50                  55                  60
Ser Met Asn Pro Phe Cys Glu Ile Ala Val Glu Glu Ala Val Arg Leu
65                  70                  75                  80
Lys Glu Lys Lys Leu Val Lys Glu Val Ile Ala Val Ser Cys Gly Pro
                85                  90                  95
Ala Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala Met Gly Ala Asp
            100                 105                 110
Arg Gly Ile His Val Glu Val Pro Pro Ala Glu Ala Glu Arg Leu Gly
        115                 120                 125
Pro Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala Glu Lys Glu Lys
    130                 135                 140
Val Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp Asp Asp Cys Asn
145                 150                 155                 160
Gln Thr Gly Gln Met Thr Ala Gly Phe Leu Asp Trp Pro Gln Gly Thr
                165                 170                 175
Phe Ala Ser Gln Val Xaa Leu Glu Gly Asp Lys Leu Lys Val Glu Arg
            180                 185                 190
Glu Ile Asp Gly Gly Leu Glu Thr Leu Arg Leu Lys Leu Pro Ala Val
        195                 200                 205
Val Thr Ala Asp Leu Arg Leu Asn Glu Pro Arg Tyr Ala Thr Leu Pro
    210                 215                 220
Asn Ile Met Lys Ala Lys Lys Lys Lys Ile Glu Val Ile Lys Pro Gly
225                 230                 235                 240
Asp Leu Gly Val Asp Leu Thr Ser Lys Leu Ser Val Ile Ser Val Glu
                245                 250                 255
Asp Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu Thr Thr Glu Asp
            260                 265                 270
Leu Val Ala Lys Leu Lys Glu Ile Gly Arg Ile
        275                 280

<210> 329
<211> 95
<212> PRT
<213> Homo sapiens

<400> 329
Met Asn Pro Phe Cys Glu Ile Ala Val Glu Glu Ala Val Arg Leu Lys
 1               5                  10                  15
Glu Lys Lys Leu Val Lys Glu Val Ile Ala Val Ser Cys Gly Pro Ala
            20                  25                  30
Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala Met Gly Ala Asp Arg
        35                  40                  45
Gly Ile His Val Glu Val Pro Pro Ala Glu Ala Glu Arg Leu Gly Pro
    50                  55                  60
Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala Glu Lys Glu Lys Val
65                  70                  75                  80
Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp Asp Asp Cys Asn
                85                  90                  95

<210> 330
<211> 255
<212> PRT
<213> Homo sapiens

<400> 330
Met Ala Glu Leu Arg Val Leu Val Ala Val Lys Arg Val Ile Asp Tyr
 1               5                  10                  15
Ala Val Lys Ile Arg Val Lys Pro Asp Arg Thr Gly Val Val Thr Asp
            20                  25                  30
Gly Val Lys His Ser Met Asn Pro Phe Cys Glu Ile Ala Val Glu Glu
        35                  40                  45
Ala Val Arg Leu Lys Glu Lys Lys Leu Val Lys Glu Val Ile Ala Val
    50                  55                  60
Ser Cys Gly Pro Ala Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala
65                  70                  75                  80
Met Gly Ala Asp Arg Gly Ile His Val Glu Val Pro Pro Ala Glu Ala
                85                  90                  95
Glu Arg Leu Gly Pro Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala
            100                 105                 110
Glu Lys Glu Lys Val Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp
        115                 120                 125
Asp Asp Cys Asn Gln Thr Gly Gln Met Thr Ala Gly Phe Leu Asp Trp
    130                 135                 140
Pro Gln Gly Thr Phe Ala Ser Gln Val Thr Leu Glu Gly Asp Lys Leu
145                 150                 155                 160
Lys Val Glu Arg Glu Ile Asp Gly Gly Leu Glu Thr Leu Arg Leu Lys
                165                 170                 175
Leu Pro Ala Val Val Thr Ala Asp Leu Arg Leu Asn Glu Pro Arg Tyr
            180                 185                 190
Ala Thr Leu Pro Asn Ile Met Lys Ala Lys Lys Lys Lys Ile Glu Val
        195                 200                 205
Ile Lys Pro Gly Asp Leu Gly Val Asp Leu Thr Ser Lys Leu Ser Val
    210                 215                 220
Ile Ser Val Glu Asp Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu
225                 230                 235                 240
Thr Thr Glu Asp Leu Val Ala Lys Leu Lys Glu Ile Gly Arg Ile
                245                 250                 255

<210> 331
<211> 255
<212> PRT
<213> Homo sapiens

<400> 331
Met Ala Glu Leu Arg Val Leu Val Ala Val Lys Arg Val Ile Asp Tyr
 1               5                  10                  15
Ala Val Lys Ile Arg Val Lys Pro Asp Arg Thr Gly Val Val Thr Asp
            20                  25                  30
Gly Val Lys His Ser Met Asn Pro Phe Cys Glu Ile Ala Val Glu Glu
        35                  40                  45
Ala Val Arg Leu Lys Glu Lys Lys Leu Val Lys Glu Val Ile Ala Val
    50                  55                  60
Ser Cys Gly Pro Ala Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala
65                  70                  75                  80
Met Gly Ala Asp Arg Gly Ile His Val Glu Val Pro Pro Ala Glu Ala
                85                  90                  95
Glu Arg Leu Gly Pro Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala
            100                 105                 110
Glu Lys Glu Lys Val Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp
        115                 120                 125
Asp Asp Cys Asn Gln Thr Gly Gln Met Thr Ala Gly Phe Leu Asp Trp
    130                 135                 140
Pro Gln Gly Thr Phe Ala Ser Gln Val Thr Leu Glu Gly Asp Lys Leu
145                 150                 155                 160
Lys Val Glu Arg Glu Ile Asp Gly Gly Leu Glu Thr Leu Arg Leu Lys
                165                 170                 175
Leu Pro Ala Val Val Thr Ala Asp Leu Arg Leu Asn Glu Pro Arg Tyr
            180                 185                 190
Ala Thr Leu Pro Asn Ile Met Lys Ala Lys Lys Lys Lys Ile Glu Val
        195                 200                 205
Ile Lys Pro Gly Asp Leu Gly Val Asp Leu Thr Ser Lys Leu Ser Val
    210                 215                 220
Ile Ser Val Glu Asp Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu
225                 230                 235                 240
Thr Thr Glu Asp Leu Val Ala Lys Leu Lys Glu Ile Gly Arg Ile
                245                 250                 255

<210> 332
<211> 928
<212> PRT
<213> Homo sapiens

<400> 332
Met Glu Pro Arg Asp Gly Ser Pro Glu Ala Arg Ser Ser Asp Ser Glu
 1               5                  10                  15
Ser Ala Ser Ala Ser Ser Ser Gly Ser Glu Arg Asp Ala Gly Pro Glu
            20                  25                  30
Pro Asp Lys Ala Pro Arg Arg Leu Asn Lys Arg Arg Phe Pro Gly Leu
        35                  40                  45
Arg Leu Phe Gly His Arg Lys Ala Ile Thr Lys Ser Gly Leu Gln His
    50                  55                  60
Leu Ala Pro Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu
65                  70                  75                  80
Arg Gln Ile Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly
                85                  90                  95
Glu His Ile Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val
            100                 105                 110
Gly Glu Gln Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg
        115                 120                 125
Lys Cys Ala Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln
    130                 135                 140
Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly
145                 150                 155                 160
Ser Arg Asn Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His
                165                 170                 175
Arg Arg Arg Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln
            180                 185                 190
Gln Lys Phe Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser
        195                 200                 205
Trp Cys Lys Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln
    210                 215                 220
Gln Ile Glu Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile
225                 230                 235                 240
Pro Pro Thr Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys
                245                 250                 255
Ala Ser Lys Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys
            260                 265                 270
Lys Gly Pro Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr
        275                 280                 285
Pro Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser
    290                 295                 300
Gly Gly Asn Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu
305                 310                 315                 320
Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala
                325                 330                 335
Leu Glu Met Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly
            340                 345                 350
Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg
        355                 360                 365
Leu Lys Pro Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn
    370                 375                 380
Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro
385                 390                 395                 400
Val Ser Lys Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu
                405                 410                 415
Asp Arg Trp Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu
            420                 425                 430
Asp Arg Asp Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn
        435                 440                 445
Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His
    450                 455                 460
Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn
465                 470                 475                 480
Lys Met Phe Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser
                485                 490                 495
Ser Lys Asp Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp
            500                 505                 510
Leu Thr Pro Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu
        515                 520                 525
Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly
    530                 535                 540
Glu His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu
545                 550                 555                 560
Val Ile Gly Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly
                565                 570                 575
His Gly Glu Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser
            580                 585                 590
Lys Ala Ile Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala
        595                 600                 605
Ser Arg Ile Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys
    610                 615                 620
Ala Lys Arg Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val
625                 630                 635                 640
Pro Glu Gln Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr
                645                 650                 655
Glu Ala Leu His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro
            660                 665                 670
Leu Gly Thr Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg
        675                 680                 685
Ala His Ile Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys
    690                 695                 700
Ser Pro Thr Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala
705                 710                 715                 720
Thr Thr Ala Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu
                725                 730                 735
Asn Tyr Val Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro
            740                 745                 750
Glu Leu Leu Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser
        755                 760                 765
Pro Leu Pro Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly
    770                 775                 780
Asp Ala Ala Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg
785                 790                 795                 800
Asn Asp Phe Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu
                805                 810                 815
Met His Arg Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser
            820                 825                 830
Thr Gly Ser Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro
        835                 840                 845
Glu Ile Leu Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln
    850                 855                 860
Ala Ala Ala Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala
865                 870                 875                 880
Gly Ala Ser Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln
                885                 890                 895
Arg Ala Glu Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn
            900                 905                 910
Arg Gln His Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val
        915                 920                 925

<210> 333
<211> 1117
<212> PRT
<213> Homo sapiens

<400> 333
Met Glu Thr Phe Phe Arg Arg His Phe Arg Gly Lys Val Pro Gly Pro
 1               5                  10                  15
Gly Glu Gly Gln Arg Arg Pro Ser Ser Val Gly Leu Pro Thr Gly Lys
            20                  25                  30
Ala Arg Arg Arg Ser Pro Ala Gly Gln Ala Ser Ser Ser Leu Ala Gln
        35                  40                  45
Arg Arg Arg Ser Ser Ala Gln Leu Gln Gly Cys Leu Leu Ser Cys Gly
    50                  55                  60
Val Arg Ala Gln Gly Ser Ser Arg Arg Arg Ser Ser Thr Val Pro Pro
65                  70                  75                  80
Ser Cys Asn Pro Arg Phe Ile Val Asp Lys Val Leu Thr Pro Gln Pro
                85                  90                  95
Thr Thr Val Gly Ala Gln Leu Leu Gly Ala Pro Leu Leu Leu Thr Gly
            100                 105                 110
Leu Val Gly Met Asn Glu Glu Glu Gly Val Gln Glu Asp Val Val Ala
        115                 120                 125
Glu Ala Ser Ser Ala Ile Gln Pro Gly Thr Lys Thr Pro Gly Pro Pro
    130                 135                 140
Pro Pro Arg Gly Ala Gln Pro Leu Leu Pro Leu Pro Arg Tyr Val Arg
145                 150                 155                 160
Arg Ala Ser Ser His Cys Cys Pro Ala Asp Ala Val Tyr Asp His Ala
                165                 170                 175
Leu Trp Gly Leu His Gly Tyr Tyr Arg Arg Leu Ser Gln Arg Arg Pro
            180                 185                 190
Ser Gly Gln His Pro Gly Pro Gly Gly Arg Arg Ala Ser Gly Thr Thr
        195                 200                 205
Ala Gly Thr Met Leu Pro Thr Arg Val Arg Pro Leu Ser Arg Arg Arg
    210                 215                 220
Gln Val Ala Leu Arg Arg Lys Ala Ala Gly Pro Gln Ala Trp Ser Ala
225                 230                 235                 240
Leu Leu Ala Lys Ala Ile Thr Lys Ser Gly Leu Gln His Leu Ala Pro
                245                 250                 255
Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu Arg Gln Ile
            260                 265                 270
Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly Glu His Ile
        275                 280                 285
Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val Gly Glu Gln
    290                 295                 300
Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg Lys Cys Ala
305                 310                 315                 320
Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln Leu Glu Lys
                325                 330                 335
Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly Ser Arg Asn
            340                 345                 350
Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His Arg Arg Arg
        355                 360                 365
Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln Gln Lys Phe
    370                 375                 380
Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp Cys Lys
385                 390                 395                 400
Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln Gln Ile Glu
                405                 410                 415
Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile Pro Pro Thr
            420                 425                 430
Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys Ala Ser Lys
        435                 440                 445
Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys Lys Gly Pro
    450                 455                 460
Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr Pro Ser Pro
465                 470                 475                 480
Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Asn
                485                 490                 495
Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu Asn Pro Arg
            500                 505                 510
Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala Leu Glu Met
        515                 520                 525
Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly Gly Asp Gly
    530                 535                 540
Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg Leu Lys Pro
545                 550                 555                 560
Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala
                565                 570                 575
Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro Val Ser Lys
            580                 585                 590
Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu Asp Arg Trp
        595                 600                 605
Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu Asp Arg Asp
    610                 615                 620
Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn Asn Tyr Phe
625                 630                 635                 640
Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His Glu Ser Arg
                645                 650                 655
Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn Lys Met Phe
            660                 665                 670
Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser Ser Lys Asp
        675                 680                 685
Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp Leu Thr Pro
    690                 695                 700
Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu Asn Ile Pro
705                 710                 715                 720
Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly Glu His His
                725                 730                 735
Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu Val Ile Gly
            740                 745                 750
Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly His Gly Glu
        755                 760                 765
Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser Lys Ala Ile
    770                 775                 780
Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala Ser Arg Ile
785                 790                 795                 800
Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys Ala Lys Arg
                805                 810                 815
Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val Pro Glu Gln
            820                 825                 830
Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr Glu Ala Leu
        835                 840                 845
His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro Leu Gly Thr
    850                 855                 860
Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg Ala His Ile
865                 870                 875                 880
Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys Ser Pro Thr
                885                 890                 895
Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala Thr Thr Ala
            900                 905                 910
Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu Asn Tyr Val
        915                 920                 925
Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro Glu Leu Leu
    930                 935                 940
Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser Pro Leu Pro
945                 950                 955                 960
Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly Asp Ala Ala
                965                 970                 975
Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg Asn Asp Phe
            980                 985                 990
Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu Met His Arg
        995                 1000                1005
Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser Thr Gly Ser
    1010                1015                1020
Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro Glu Ile Leu
1025                1030                1035                1040
Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln Ala Ala Ala
                1045                1050                1055
Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala Gly Ala Ser
            1060                1065                1070
Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln Arg Ala Glu
        1075                1080                1085
Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn Arg Gln His
    1090                1095                1100
Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val
1105                1110                1115

<210> 334
<211> 928
<212> PRT
<213> Homo sapiens

<400> 334
Met Glu Pro Arg Asp Gly Ser Pro Glu Ala Arg Ser Ser Asp Ser Glu
 1               5                  10                  15
Ser Ala Ser Ala Ser Ser Ser Gly Ser Glu Arg Asp Ala Gly Pro Glu
            20                  25                  30
Pro Asp Lys Ala Pro Arg Arg Leu Asn Lys Arg Arg Phe Pro Gly Leu
        35                  40                  45
Arg Leu Phe Gly His Arg Lys Ala Ile Thr Lys Ser Gly Leu Gln His
    50                  55                  60
Leu Ala Pro Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu
65                  70                  75                  80
Arg Gln Ile Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly
                85                  90                  95
Glu His Ile Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val
            100                 105                 110
Gly Glu Gln Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg
        115                 120                 125
Lys Cys Ala Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln
    130                 135                 140
Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly
145                 150                 155                 160
Ser Arg Asn Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His
                165                 170                 175
Arg Arg Arg Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln
            180                 185                 190
Gln Lys Phe Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser
        195                 200                 205
Trp Cys Lys Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln
    210                 215                 220
Gln Ile Glu Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile
225                 230                 235                 240
Pro Pro Thr Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys
                245                 250                 255
Ala Ser Lys Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys
            260                 265                 270
Lys Gly Pro Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr
        275                 280                 285
Pro Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser
    290                 295                 300
Gly Gly Asn Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu
305                 310                 315                 320
Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala
                325                 330                 335
Leu Glu Met Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly
            340                 345                 350
Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg
        355                 360                 365
Leu Lys Pro Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn
    370                 375                 380
Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro
385                 390                 395                 400
Val Ser Lys Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu
                405                 410                 415
Asp Arg Trp Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu
            420                 425                 430
Asp Arg Asp Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn
        435                 440                 445
Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His
    450                 455                 460
Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn
465                 470                 475                 480
Lys Met Phe Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser
                485                 490                 495
Ser Lys Asp Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp
            500                 505                 510
Leu Thr Pro Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu
        515                 520                 525
Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly
    530                 535                 540
Glu His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu
545                 550                 555                 560
Val Ile Gly Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly
                565                 570                 575
His Gly Glu Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser
            580                 585                 590
Lys Ala Ile Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala
        595                 600                 605
Ser Arg Ile Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys
    610                 615                 620
Ala Lys Arg Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val
625                 630                 635                 640
Pro Glu Gln Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr
                645                 650                 655
Glu Ala Leu His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro
            660                 665                 670
Leu Gly Thr Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg
        675                 680                 685
Ala His Ile Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys
    690                 695                 700
Ser Pro Thr Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala
705                 710                 715                 720
Thr Thr Ala Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu
                725                 730                 735
Asn Tyr Val Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro
            740                 745                 750
Glu Leu Leu Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser
        755                 760                 765
Pro Leu Pro Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly
    770                 775                 780
Asp Ala Ala Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg
785                 790                 795                 800
Asn Asp Phe Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu
                805                 810                 815
Met His Arg Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser
            820                 825                 830
Thr Gly Ser Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro
        835                 840                 845
Glu Ile Leu Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln
    850                 855                 860
Ala Ala Ala Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala
865                 870                 875                 880
Gly Ala Ser Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln
                885                 890                 895
Arg Ala Glu Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn
            900                 905                 910
Arg Gln His Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val
        915                 920                 925

<210> 335
<211> 1117
<212> PRT
<213> Homo sapiens

<400> 335
Met Glu Thr Phe Phe Arg Arg His Phe Arg Gly Lys Val Pro Gly Pro
 1               5                  10                  15
Gly Glu Gly Gln Arg Arg Pro Ser Ser Val Gly Leu Pro Thr Gly Lys
            20                  25                  30
Ala Arg Arg Arg Ser Pro Ala Gly Gln Ala Ser Ser Ser Leu Ala Gln
        35                  40                  45
Arg Arg Arg Ser Ser Ala Gln Leu Gln Gly Cys Leu Leu Ser Cys Gly
    50                  55                  60
Val Arg Ala Gln Gly Ser Ser Arg Arg Arg Ser Ser Thr Val Pro Pro
65                  70                  75                  80
Ser Cys Asn Pro Arg Phe Ile Val Asp Lys Val Leu Thr Pro Gln Pro
                85                  90                  95
Thr Thr Val Gly Ala Gln Leu Leu Gly Ala Pro Leu Leu Leu Thr Gly
            100                 105                 110
Leu Val Gly Met Asn Glu Glu Glu Gly Val Gln Glu Asp Val Val Ala
        115                 120                 125
Glu Ala Ser Ser Ala Ile Gln Pro Gly Thr Lys Thr Pro Gly Pro Pro
    130                 135                 140
Pro Pro Arg Gly Ala Gln Pro Leu Leu Pro Leu Pro Arg Tyr Val Arg
145                 150                 155                 160
Arg Ala Ser Ser His Cys Cys Pro Ala Asp Ala Val Tyr Asp His Ala
                165                 170                 175
Leu Trp Gly Leu His Gly Tyr Tyr Arg Arg Leu Ser Gln Arg Arg Pro
            180                 185                 190
Ser Gly Gln His Pro Gly Pro Gly Gly Arg Arg Ala Ser Gly Thr Thr
        195                 200                 205
Ala Gly Thr Met Leu Pro Thr Arg Val Arg Pro Leu Ser Arg Arg Arg
    210                 215                 220
Gln Val Ala Leu Arg Arg Lys Ala Ala Gly Pro Gln Ala Trp Ser Ala
225                 230                 235                 240
Leu Leu Ala Lys Ala Ile Thr Lys Ser Gly Leu Gln His Leu Ala Pro
                245                 250                 255
Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu Arg Gln Ile
            260                 265                 270
Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly Glu His Ile
        275                 280                 285
Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val Gly Glu Gln
    290                 295                 300
Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg Lys Cys Ala
305                 310                 315                 320
Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln Leu Glu Lys
                325                 330                 335
Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly Ser Arg Asn
            340                 345                 350
Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His Arg Arg Arg
        355                 360                 365
Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln Gln Lys Phe
    370                 375                 380
Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp Cys Lys
385                 390                 395                 400
Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln Gln Ile Glu
                405                 410                 415
Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile Pro Pro Thr
            420                 425                 430
Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys Ala Ser Lys
        435                 440                 445
Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys Lys Gly Pro
    450                 455                 460
Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr Pro Ser Pro
465                 470                 475                 480
Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Asn
                485                 490                 495
Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu Asn Pro Arg
            500                 505                 510
Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala Leu Glu Met
        515                 520                 525
Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly Gly Asp Gly
    530                 535                 540
Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg Leu Lys Pro
545                 550                 555                 560
Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala
                565                 570                 575
Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro Val Ser Lys
            580                 585                 590
Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu Asp Arg Trp
        595                 600                 605
Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu Asp Arg Asp
    610                 615                 620
Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn Asn Tyr Phe
625                 630                 635                 640
Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His Glu Ser Arg
                645                 650                 655
Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn Lys Met Phe
            660                 665                 670
Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser Ser Lys Asp
        675                 680                 685
Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp Leu Thr Pro
    690                 695                 700
Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu Asn Ile Pro
705                 710                 715                 720
Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly Glu His His
                725                 730                 735
Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu Val Ile Gly
            740                 745                 750
Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly His Gly Glu
        755                 760                 765
Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser Lys Ala Ile
    770                 775                 780
Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala Ser Arg Ile
785                 790                 795                 800
Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys Ala Lys Arg
                805                 810                 815
Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val Pro Glu Gln
            820                 825                 830
Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr Glu Ala Leu
        835                 840                 845
His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro Leu Gly Thr
    850                 855                 860
Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg Ala His Ile
865                 870                 875                 880
Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys Ser Pro Thr
                885                 890                 895
Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala Thr Thr Ala
            900                 905                 910
Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu Asn Tyr Val
        915                 920                 925
Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro Glu Leu Leu
    930                 935                 940
Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser Pro Leu Pro
945                 950                 955                 960
Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly Asp Ala Ala
                965                 970                 975
Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg Asn Asp Phe
            980                 985                 990
Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu Met His Arg
        995                 1000                1005
Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser Thr Gly Ser
    1010                1015                1020
Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro Glu Ile Leu
1025                1030                1035                1040
Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln Ala Ala Ala
                1045                1050                1055
Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala Gly Ala Ser
            1060                1065                1070
Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln Arg Ala Glu
        1075                1080                1085
Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn Arg Gln His
    1090                1095                1100
Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val
1105                1110                1115

<210> 336
<211> 928
<212> PRT
<213> Homo sapiens

<400> 336
Met Glu Pro Arg Asp Gly Ser Pro Glu Ala Arg Ser Ser Asp Ser Glu
 1               5                  10                  15
Ser Ala Ser Ala Ser Ser Ser Gly Ser Glu Arg Asp Ala Gly Pro Glu
            20                  25                  30
Pro Asp Lys Ala Pro Arg Arg Leu Asn Lys Arg Arg Phe Pro Gly Leu
        35                  40                  45
Arg Leu Phe Gly His Arg Lys Ala Ile Thr Lys Ser Gly Leu Gln His
    50                  55                  60
Leu Ala Pro Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu
65                  70                  75                  80
Arg Gln Ile Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly
                85                  90                  95
Glu His Ile Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val
            100                 105                 110
Gly Glu Gln Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg
        115                 120                 125
Lys Cys Ala Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln
    130                 135                 140
Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly
145                 150                 155                 160
Ser Arg Asn Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His
                165                 170                 175
Arg Arg Arg Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln
            180                 185                 190
Gln Lys Phe Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser
        195                 200                 205
Trp Cys Lys Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln
    210                 215                 220
Gln Ile Glu Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile
225                 230                 235                 240
Pro Pro Thr Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys
                245                 250                 255
Ala Ser Lys Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys
            260                 265                 270
Lys Gly Pro Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr
        275                 280                 285
Pro Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser
    290                 295                 300
Gly Gly Asn Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu
305                 310                 315                 320
Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala
                325                 330                 335
Leu Glu Met Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly
            340                 345                 350
Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg
        355                 360                 365
Leu Lys Pro Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn
    370                 375                 380
Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro
385                 390                 395                 400
Val Ser Lys Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu
                405                 410                 415
Asp Arg Trp Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu
            420                 425                 430
Asp Arg Asp Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn
        435                 440                 445
Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His
    450                 455                 460
Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn
465                 470                 475                 480
Lys Met Phe Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser
                485                 490                 495
Ser Lys Asp Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp
            500                 505                 510
Leu Thr Pro Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu
        515                 520                 525
Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly
    530                 535                 540
Glu His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu
545                 550                 555                 560
Val Ile Gly Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly
                565                 570                 575
His Gly Glu Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser
            580                 585                 590
Lys Ala Ile Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala
        595                 600                 605
Ser Arg Ile Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys
    610                 615                 620
Ala Lys Arg Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val
625                 630                 635                 640
Pro Glu Gln Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr
                645                 650                 655
Glu Ala Leu His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro
            660                 665                 670
Leu Gly Thr Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg
        675                 680                 685
Ala His Ile Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys
    690                 695                 700
Ser Pro Thr Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala
705                 710                 715                 720
Thr Thr Ala Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu
                725                 730                 735
Asn Tyr Val Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro
            740                 745                 750
Glu Leu Leu Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser
        755                 760                 765
Pro Leu Pro Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly
    770                 775                 780
Asp Ala Ala Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg
785                 790                 795                 800
Asn Asp Phe Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu
                805                 810                 815
Met His Arg Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser
            820                 825                 830
Thr Gly Ser Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro
        835                 840                 845
Glu Ile Leu Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln
    850                 855                 860
Ala Ala Ala Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala
865                 870                 875                 880
Gly Ala Ser Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln
                885                 890                 895
Arg Ala Glu Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn
            900                 905                 910
Arg Gln His Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val
        915                 920                 925

<210> 337
<211> 1117
<212> PRT
<213> Homo sapiens

<400> 337
Met Glu Thr Phe Phe Arg Arg His Phe Arg Gly Lys Val Pro Gly Pro
 1               5                  10                  15
Gly Glu Gly Gln Arg Arg Pro Ser Ser Val Gly Leu Pro Thr Gly Lys
            20                  25                  30
Ala Arg Arg Arg Ser Pro Ala Gly Gln Ala Ser Ser Ser Leu Ala Gln
        35                  40                  45
Arg Arg Arg Ser Ser Ala Gln Leu Gln Gly Cys Leu Leu Ser Cys Gly
    50                  55                  60
Val Arg Ala Gln Gly Ser Ser Arg Arg Arg Ser Ser Thr Val Pro Pro
65                  70                  75                  80
Ser Cys Asn Pro Arg Phe Ile Val Asp Lys Val Leu Thr Pro Gln Pro
                85                  90                  95
Thr Thr Val Gly Ala Gln Leu Leu Gly Ala Pro Leu Leu Leu Thr Gly
            100                 105                 110
Leu Val Gly Met Asn Glu Glu Glu Gly Val Gln Glu Asp Val Val Ala
        115                 120                 125
Glu Ala Ser Ser Ala Ile Gln Pro Gly Thr Lys Thr Pro Gly Pro Pro
    130                 135                 140
Pro Pro Arg Gly Ala Gln Pro Leu Leu Pro Leu Pro Arg Tyr Val Arg
145                 150                 155                 160
Arg Ala Ser Ser His Cys Cys Pro Ala Asp Ala Val Tyr Asp His Ala
                165                 170                 175
Leu Trp Gly Leu His Gly Tyr Tyr Arg Arg Leu Ser Gln Arg Arg Pro
            180                 185                 190
Ser Gly Gln His Pro Gly Pro Gly Gly Arg Arg Ala Ser Gly Thr Thr
        195                 200                 205
Ala Gly Thr Met Leu Pro Thr Arg Val Arg Pro Leu Ser Arg Arg Arg
    210                 215                 220
Gln Val Ala Leu Arg Arg Lys Ala Ala Gly Pro Gln Ala Trp Ser Ala
225                 230                 235                 240
Leu Leu Ala Lys Ala Ile Thr Lys Ser Gly Leu Gln His Leu Ala Pro
                245                 250                 255
Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu Arg Gln Ile
            260                 265                 270
Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly Glu His Ile
        275                 280                 285
Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val Gly Glu Gln
    290                 295                 300
Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg Lys Cys Ala
305                 310                 315                 320
Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln Leu Glu Lys
                325                 330                 335
Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly Ser Arg Asn
            340                 345                 350
Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His Arg Arg Arg
        355                 360                 365
Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln Gln Lys Phe
    370                 375                 380
Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp Cys Lys
385                 390                 395                 400
Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln Gln Ile Glu
                405                 410                 415
Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile Pro Pro Thr
            420                 425                 430
Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys Ala Ser Lys
        435                 440                 445
Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys Lys Gly Pro
    450                 455                 460
Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr Pro Ser Pro
465                 470                 475                 480
Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Asn
                485                 490                 495
Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu Asn Pro Arg
            500                 505                 510
Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala Leu Glu Met
        515                 520                 525
Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly Gly Asp Gly
    530                 535                 540
Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg Leu Lys Pro
545                 550                 555                 560
Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala
                565                 570                 575
Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro Val Ser Lys
            580                 585                 590
Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu Asp Arg Trp
        595                 600                 605
Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu Asp Arg Asp
    610                 615                 620
Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn Asn Tyr Phe
625                 630                 635                 640
Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His Glu Ser Arg
                645                 650                 655
Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn Lys Met Phe
            660                 665                 670
Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser Ser Lys Asp
        675                 680                 685
Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp Leu Thr Pro
    690                 695                 700
Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu Asn Ile Pro
705                 710                 715                 720
Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly Glu His His
                725                 730                 735
Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu Val Ile Gly
            740                 745                 750
Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly His Gly Glu
        755                 760                 765
Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser Lys Ala Ile
    770                 775                 780
Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala Ser Arg Ile
785                 790                 795                 800
Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys Ala Lys Arg
                805                 810                 815
Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val Pro Glu Gln
            820                 825                 830
Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr Glu Ala Leu
        835                 840                 845
His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro Leu Gly Thr
    850                 855                 860
Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg Ala His Ile
865                 870                 875                 880
Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys Ser Pro Thr
                885                 890                 895
Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala Thr Thr Ala
            900                 905                 910
Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu Asn Tyr Val
        915                 920                 925
Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro Glu Leu Leu
    930                 935                 940
Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser Pro Leu Pro
945                 950                 955                 960
Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly Asp Ala Ala
                965                 970                 975
Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg Asn Asp Phe
            980                 985                 990
Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu Met His Arg
        995                 1000                1005
Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser Thr Gly Ser
    1010                1015                1020
Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro Glu Ile Leu
1025                1030                1035                1040
Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln Ala Ala Ala
                1045                1050                1055
Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala Gly Ala Ser
            1060                1065                1070
Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln Arg Ala Glu
        1075                1080                1085
Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn Arg Gln His
    1090                1095                1100
Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val
1105                1110                1115

<210> 338
<211> 928
<212> PRT
<213> Homo sapiens

<400> 338
Met Glu Pro Arg Asp Gly Ser Pro Glu Ala Arg Ser Ser Asp Ser Glu
 1               5                  10                  15
Ser Ala Ser Ala Ser Ser Ser Gly Ser Glu Arg Asp Ala Gly Pro Glu
            20                  25                  30
Pro Asp Lys Ala Pro Arg Arg Leu Asn Lys Arg Arg Phe Pro Gly Leu
        35                  40                  45
Arg Leu Phe Gly His Arg Lys Ala Ile Thr Lys Ser Gly Leu Gln His
    50                  55                  60
Leu Ala Pro Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu
65                  70                  75                  80
Arg Gln Ile Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly
                85                  90                  95
Glu His Ile Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val
            100                 105                 110
Gly Glu Gln Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg
        115                 120                 125
Lys Cys Ala Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln
    130                 135                 140
Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly
145                 150                 155                 160
Ser Arg Asn Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His
                165                 170                 175
Arg Arg Arg Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln
            180                 185                 190
Gln Lys Phe Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser
        195                 200                 205
Trp Cys Lys Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln
    210                 215                 220
Gln Ile Glu Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile
225                 230                 235                 240
Pro Pro Thr Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys
                245                 250                 255
Ala Ser Lys Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys
            260                 265                 270
Lys Gly Pro Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr
        275                 280                 285
Pro Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser
    290                 295                 300
Gly Gly Asn Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu
305                 310                 315                 320
Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala
                325                 330                 335
Leu Glu Met Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly
            340                 345                 350
Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg
        355                 360                 365
Leu Lys Pro Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn
    370                 375                 380
Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro
385                 390                 395                 400
Val Ser Lys Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu
                405                 410                 415
Asp Arg Trp Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu
            420                 425                 430
Asp Arg Asp Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn
        435                 440                 445
Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His
    450                 455                 460
Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn
465                 470                 475                 480
Lys Met Phe Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser
                485                 490                 495
Ser Lys Asp Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp
            500                 505                 510
Leu Thr Pro Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu
        515                 520                 525
Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly
    530                 535                 540
Glu His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu
545                 550                 555                 560
Val Ile Gly Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly
                565                 570                 575
His Gly Glu Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser
            580                 585                 590
Lys Ala Ile Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala
        595                 600                 605
Ser Arg Ile Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys
    610                 615                 620
Ala Lys Arg Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val
625                 630                 635                 640
Pro Glu Gln Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr
                645                 650                 655
Glu Ala Leu His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro
            660                 665                 670
Leu Gly Thr Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg
        675                 680                 685
Ala His Ile Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys
    690                 695                 700
Ser Pro Thr Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala
705                 710                 715                 720
Thr Thr Ala Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu
                725                 730                 735
Asn Tyr Val Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro
            740                 745                 750
Glu Leu Leu Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser
        755                 760                 765
Pro Leu Pro Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly
    770                 775                 780
Asp Ala Ala Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg
785                 790                 795                 800
Asn Asp Phe Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu
                805                 810                 815
Met His Arg Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser
            820                 825                 830
Thr Gly Ser Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro
        835                 840                 845
Glu Ile Leu Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln
    850                 855                 860
Ala Ala Ala Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala
865                 870                 875                 880
Gly Ala Ser Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln
                885                 890                 895
Arg Ala Glu Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn
            900                 905                 910
Arg Gln His Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val
        915                 920                 925

<210> 339
<211> 1117
<212> PRT
<213> Homo sapiens

<400> 339
Met Glu Thr Phe Phe Arg Arg His Phe Arg Gly Lys Val Pro Gly Pro
 1               5                  10                  15
Gly Glu Gly Gln Arg Arg Pro Ser Ser Val Gly Leu Pro Thr Gly Lys
            20                  25                  30
Ala Arg Arg Arg Ser Pro Ala Gly Gln Ala Ser Ser Ser Leu Ala Gln
        35                  40                  45
Arg Arg Arg Ser Ser Ala Gln Leu Gln Gly Cys Leu Leu Ser Cys Gly
    50                  55                  60
Val Arg Ala Gln Gly Ser Ser Arg Arg Arg Ser Ser Thr Val Pro Pro
65                  70                  75                  80
Ser Cys Asn Pro Arg Phe Ile Val Asp Lys Val Leu Thr Pro Gln Pro
                85                  90                  95
Thr Thr Val Gly Ala Gln Leu Leu Gly Ala Pro Leu Leu Leu Thr Gly
            100                 105                 110
Leu Val Gly Met Asn Glu Glu Glu Gly Val Gln Glu Asp Val Val Ala
        115                 120                 125
Glu Ala Ser Ser Ala Ile Gln Pro Gly Thr Lys Thr Pro Gly Pro Pro
    130                 135                 140
Pro Pro Arg Gly Ala Gln Pro Leu Leu Pro Leu Pro Arg Tyr Val Arg
145                 150                 155                 160
Arg Ala Ser Ser His Cys Cys Pro Ala Asp Ala Val Tyr Asp His Ala
                165                 170                 175
Leu Trp Gly Leu His Gly Tyr Tyr Arg Arg Leu Ser Gln Arg Arg Pro
            180                 185                 190
Ser Gly Gln His Pro Gly Pro Gly Gly Arg Arg Ala Ser Gly Thr Thr
        195                 200                 205
Ala Gly Thr Met Leu Pro Thr Arg Val Arg Pro Leu Ser Arg Arg Arg
    210                 215                 220
Gln Val Ala Leu Arg Arg Lys Ala Ala Gly Pro Gln Ala Trp Ser Ala
225                 230                 235                 240
Leu Leu Ala Lys Ala Ile Thr Lys Ser Gly Leu Gln His Leu Ala Pro
                245                 250                 255
Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu Arg Gln Ile
            260                 265                 270
Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly Glu His Ile
        275                 280                 285
Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val Gly Glu Gln
    290                 295                 300
Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg Lys Cys Ala
305                 310                 315                 320
Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln Leu Glu Lys
                325                 330                 335
Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly Ser Arg Asn
            340                 345                 350
Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His Arg Arg Arg
        355                 360                 365
Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln Gln Lys Phe
    370                 375                 380
Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp Cys Lys
385                 390                 395                 400
Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln Gln Ile Glu
                405                 410                 415
Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile Pro Pro Thr
            420                 425                 430
Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys Ala Ser Lys
        435                 440                 445
Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys Lys Gly Pro
    450                 455                 460
Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr Pro Ser Pro
465                 470                 475                 480
Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Asn
                485                 490                 495
Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu Asn Pro Arg
            500                 505                 510
Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala Leu Glu Met
        515                 520                 525
Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly Gly Asp Gly
    530                 535                 540
Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg Leu Lys Pro
545                 550                 555                 560
Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala
                565                 570                 575
Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro Val Ser Lys
            580                 585                 590
Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu Asp Arg Trp
        595                 600                 605
Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu Asp Arg Asp
    610                 615                 620
Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn Asn Tyr Phe
625                 630                 635                 640
Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His Glu Ser Arg
                645                 650                 655
Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn Lys Met Phe
            660                 665                 670
Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser Ser Lys Asp
        675                 680                 685
Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp Leu Thr Pro
    690                 695                 700
Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu Asn Ile Pro
705                 710                 715                 720
Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly Glu His His
                725                 730                 735
Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu Val Ile Gly
            740                 745                 750
Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly His Gly Glu
        755                 760                 765
Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser Lys Ala Ile
    770                 775                 780
Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala Ser Arg Ile
785                 790                 795                 800
Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys Ala Lys Arg
                805                 810                 815
Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val Pro Glu Gln
            820                 825                 830
Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr Glu Ala Leu
        835                 840                 845
His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro Leu Gly Thr
    850                 855                 860
Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg Ala His Ile
865                 870                 875                 880
Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys Ser Pro Thr
                885                 890                 895
Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala Thr Thr Ala
            900                 905                 910
Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu Asn Tyr Val
        915                 920                 925
Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro Glu Leu Leu
    930                 935                 940
Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser Pro Leu Pro
945                 950                 955                 960
Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly Asp Ala Ala
                965                 970                 975
Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg Asn Asp Phe
            980                 985                 990
Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp Leu Met His Arg
        995                 1000                1005
Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val Ser Thr Gly Ser
    1010                1015                1020
Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro Pro Glu Ile Leu
1025                1030                1035                1040
Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His Gln Ala Ala Ala
                1045                1050                1055
Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu Ala Gly Ala Ser
            1060                1065                1070
Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg Gln Arg Ala Glu
        1075                1080                1085
Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu Asn Arg Gln His
    1090                1095                1100
Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala Val
1105                1110                1115

<210> 340
<211> 125
<212> PRT
<213> Homo sapiens

<400> 340
Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu
 1               5                  10                  15
Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala
            20                  25                  30
Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu
        35                  40                  45
Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro
    50                  55                  60
Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr
65                  70                  75                  80
Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu
                85                  90                  95
Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val Lys Phe Asn
            100                 105                 110
Arg Arg Lys Val Met Asp Ser Asp Glu Asp Asp Asp Tyr
        115                 120                 125

<210> 341
<211> 125
<212> PRT
<213> Homo sapiens

<400> 341
Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu
 1               5                  10                  15
Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala
            20                  25                  30
Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu
        35                  40                  45
Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro
    50                  55                  60
Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr
65                  70                  75                  80
Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu
                85                  90                  95
Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val Lys Phe Asn
            100                 105                 110
Arg Arg Lys Val Met Asp Ser Asp Glu Asp Asp Asp Tyr
        115                 120                 125

<210> 342
<211> 128
<212> PRT
<213> Homo sapiens

<400> 342
Arg Arg Ala Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg
 1               5                  10                  15
Leu Ala Glu Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln
            20                  25                  30
Gln Glu Ala Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala
        35                  40                  45
Gln Val Leu Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu
    50                  55                  60
Val Lys Pro Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met
65                  70                  75                  80
Ala Arg Tyr Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile
                85                  90                  95
Glu Ile Leu Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val
            100                 105                 110
Lys Val Ser Val Pro Arg Cys Leu Trp Gln Met Lys Arg Trp Ile Leu
        115                 120                 125

<210> 343
<211> 110
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(110)
<223> Xaa = Any Amino Acid

<400> 343
Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu
 1               5                  10                  15
Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala
            20                  25                  30
Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu
        35                  40                  45
Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro
    50                  55                  60
Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr
65                  70                  75                  80
Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu
                85                  90                  95
Lys Lys Val Ser Gln Gln Thr Glu Lys Xaa Thr Thr Val Arg
            100                 105                 110

<210> 344
<211> 125
<212> PRT
<213> Homo sapiens

<400> 344
Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu
 1               5                  10                  15
Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala
            20                  25                  30
Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu
        35                  40                  45
Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro
    50                  55                  60
Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr
65                  70                  75                  80
Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu
                85                  90                  95
Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val Lys Phe Asn
            100                 105                 110
Arg Arg Lys Val Met Asp Ser Asp Glu Asp Asp Asp Tyr
        115                 120                 125

<210> 345
<211> 125
<212> PRT
<213> Homo sapiens

<400> 345
Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu
 1               5                  10                  15
Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala
            20                  25                  30
Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu
        35                  40                  45
Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro
    50                  55                  60
Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr
65                  70                  75                  80
Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu
                85                  90                  95
Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val Lys Phe Asn
            100                 105                 110
Arg Arg Lys Val Met Asp Ser Asp Glu Asp Asp Asp Tyr
        115                 120                 125

<210> 346
<211> 125
<212> PRT
<213> Homo sapiens

<400> 346
Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu
 1               5                  10                  15
Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala
            20                  25                  30
Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu
        35                  40                  45
Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro
    50                  55                  60
Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr
65                  70                  75                  80
Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu
                85                  90                  95
Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val Lys Phe Asn
            100                 105                 110
Arg Arg Lys Val Met Asp Ser Asp Glu Asp Asp Asp Tyr
        115                 120                 125

<210> 347
<211> 1424
<212> PRT
<213> Homo sapiens

<400> 347
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser
                325                 330                 335
Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe
            340                 345                 350
Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe
        355                 360                 365
Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly
    370                 375                 380
Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly
385                 390                 395                 400
Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala
                405                 410                 415
Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg
            420                 425                 430
Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met
        435                 440                 445
Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser
    450                 455                 460
Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile
465                 470                 475                 480
Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln
                485                 490                 495
Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn
            500                 505                 510
Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala
        515                 520                 525
Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro
    530                 535                 540
Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser
545                 550                 555                 560
Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp
                565                 570                 575
Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His
            580                 585                 590
Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn
        595                 600                 605
Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu
    610                 615                 620
Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser
625                 630                 635                 640
Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro
                645                 650                 655
Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn
            660                 665                 670
Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu
        675                 680                 685
Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu
    690                 695                 700
Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn
705                 710                 715                 720
Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala
                725                 730                 735
Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser
            740                 745                 750
Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln
        755                 760                 765
Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys
    770                 775                 780
Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu
785                 790                 795                 800
Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser
                805                 810                 815
Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln
            820                 825                 830
Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile
        835                 840                 845
Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val
    850                 855                 860
Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro
865                 870                 875                 880
Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu
                885                 890                 895
Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr
            900                 905                 910
Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly
        915                 920                 925
Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp
    930                 935                 940
Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr
945                 950                 955                 960
Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln
                965                 970                 975
Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly
            980                 985                 990
Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly
        995                 1000                1005
Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr
    1010                1015                1020
Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro
1025                1030                1035                1040
Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln
                1045                1050                1055
Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile
            1060                1065                1070
Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu
        1075                1080                1085
Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met
    1090                1095                1100
Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro
1105                1110                1115                1120
Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn
                1125                1130                1135
Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly
            1140                1145                1150
Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys
        1155                1160                1165
Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu
    1170                1175                1180
Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala
1185                1190                1195                1200
Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Val Ser Ser
                1205                1210                1215
Gln Gln Gly Phe Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu
            1220                1225                1230
Leu Leu Ser His His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Thr Gln Ala Phe
1265                1270                1275                1280
Ser Pro Pro Pro Asn Val Thr Ala Ser Pro Ser Met Asp Gly Leu Leu
                1285                1290                1295
Ala Gly Pro Thr Met Pro Gln Ala Pro Pro Gln Gln Phe Pro Tyr Gln
            1300                1305                1310
Pro Asn Tyr Gly Met Gly Gln Gln Pro Asp Pro Ala Phe Gly Arg Val
        1315                1320                1325
Ser Ser Pro Pro Asn Ala Met Met Ser Ser Arg Met Gly Pro Ser Gln
    1330                1335                1340
Asn Pro Met Met Gln His Pro Gln Ala Ala Ser Ile Tyr Gln Ser Ser
1345                1350                1355                1360
Glu Met Lys Gly Trp Pro Ser Gly Asn Leu Ala Arg Asn Ser Ser Phe
                1365                1370                1375
Ser Gln Gln Gln Phe Ala His Gln Gly Asn Pro Ala Val Tyr Ser Met
            1380                1385                1390
Val His Met Asn Gly Ser Ser Gly His Met Gly Gln Met Asn Met Asn
        1395                1400                1405
Pro Met Pro Met Ser Gly Met Pro Met Gly Pro Asp Gln Lys Tyr Cys
    1410                1415                1420

<210> 348
<211> 1417
<212> PRT
<213> Homo sapiens

<400> 348
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Glu Ala Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser
                325                 330                 335
Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe
            340                 345                 350
Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe
        355                 360                 365
Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly
    370                 375                 380
Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly
385                 390                 395                 400
Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala
                405                 410                 415
Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg
            420                 425                 430
Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met
        435                 440                 445
Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser
    450                 455                 460
Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile
465                 470                 475                 480
Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln
                485                 490                 495
Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn
            500                 505                 510
Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala
        515                 520                 525
Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro
    530                 535                 540
Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser
545                 550                 555                 560
Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp
                565                 570                 575
Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His
            580                 585                 590
Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn
        595                 600                 605
Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu
    610                 615                 620
Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser
625                 630                 635                 640
Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro
                645                 650                 655
Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn
            660                 665                 670
Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu
        675                 680                 685
Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu
    690                 695                 700
Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn
705                 710                 715                 720
Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala
                725                 730                 735
Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser
            740                 745                 750
Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln
        755                 760                 765
Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys
    770                 775                 780
Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu
785                 790                 795                 800
Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser
                805                 810                 815
Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln
            820                 825                 830
Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile
        835                 840                 845
Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val
    850                 855                 860
Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro
865                 870                 875                 880
Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu
                885                 890                 895
Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr
            900                 905                 910
Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly
        915                 920                 925
Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp
    930                 935                 940
Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr
945                 950                 955                 960
Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln
                965                 970                 975
Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly
            980                 985                 990
Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly
        995                 1000                1005
Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr
    1010                1015                1020
Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro
1025                1030                1035                1040
Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln
                1045                1050                1055
Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile
            1060                1065                1070
Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu
        1075                1080                1085
Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met
    1090                1095                1100
Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro
1105                1110                1115                1120
Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn
                1125                1130                1135
Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly
            1140                1145                1150
Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys
        1155                1160                1165
Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu
    1170                1175                1180
Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala
1185                1190                1195                1200
Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe
                1205                1210                1215
Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His
            1220                1225                1230
His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln Gln Gln Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Gln Gln Gln Gln Gln Thr Gln Ala Phe Ser Pro Pro Pro Asn Val Thr
1265                1270                1275                1280
Ala Ser Pro Ser Met Asp Gly Leu Leu Ala Gly Pro Thr Met Pro Gln
                1285                1290                1295
Ala Pro Pro Gln Gln Phe Pro Tyr Gln Pro Asn Tyr Gly Met Gly Gln
            1300                1305                1310
Gln Pro Asp Pro Ala Phe Gly Arg Val Ser Ser Pro Pro Asn Ala Met
        1315                1320                1325
Met Ser Ser Arg Met Gly Pro Ser Gln Asn Pro Met Met Gln His Pro
    1330                1335                1340
Gln Ala Ala Ser Ile Tyr Gln Ser Ser Glu Met Lys Gly Trp Pro Ser
1345                1350                1355                1360
Gly Asn Leu Ala Arg Asn Ser Ser Phe Ser Gln Gln Gln Phe Ala His
                1365                1370                1375
Gln Gly Asn Pro Ala Val Tyr Ser Met Val His Met Asn Gly Ser Ser
            1380                1385                1390
Gly His Met Gly Gln Met Asn Met Asn Pro Met Pro Met Ser Gly Met
        1395                1400                1405
Pro Met Gly Pro Asp Gln Lys Tyr Cys
    1410                1415

<210> 349
<211> 1420
<212> PRT
<213> Homo sapiens

<400> 349
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser
                325                 330                 335
Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe
            340                 345                 350
Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe
        355                 360                 365
Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly
    370                 375                 380
Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly
385                 390                 395                 400
Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala
                405                 410                 415
Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg
            420                 425                 430
Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met
        435                 440                 445
Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser
    450                 455                 460
Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile
465                 470                 475                 480
Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln
                485                 490                 495
Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn
            500                 505                 510
Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala
        515                 520                 525
Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro
    530                 535                 540
Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser
545                 550                 555                 560
Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp
                565                 570                 575
Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His
            580                 585                 590
Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn
        595                 600                 605
Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu
    610                 615                 620
Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser
625                 630                 635                 640
Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro
                645                 650                 655
Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn
            660                 665                 670
Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu
        675                 680                 685
Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu
    690                 695                 700
Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn
705                 710                 715                 720
Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala
                725                 730                 735
Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser
            740                 745                 750
Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln
        755                 760                 765
Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys
    770                 775                 780
Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu
785                 790                 795                 800
Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser
                805                 810                 815
Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln
            820                 825                 830
Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile
        835                 840                 845
Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val
    850                 855                 860
Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro
865                 870                 875                 880
Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu
                885                 890                 895
Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr
            900                 905                 910
Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly
        915                 920                 925
Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp
    930                 935                 940
Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr
945                 950                 955                 960
Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln
                965                 970                 975
Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly
            980                 985                 990
Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly
        995                 1000                1005
Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr
    1010                1015                1020
Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro
1025                1030                1035                1040
Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln
                1045                1050                1055
Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile
            1060                1065                1070
Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu
        1075                1080                1085
Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met
    1090                1095                1100
Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro
1105                1110                1115                1120
Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn
                1125                1130                1135
Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly
            1140                1145                1150
Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys
        1155                1160                1165
Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu
    1170                1175                1180
Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala
1185                1190                1195                1200
Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe
                1205                1210                1215
Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His
            1220                1225                1230
His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln Gln Gln Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Gln Gln Gln Gln Gln Gln Gln Gln Thr Gln Ala Phe Ser Pro Pro Pro
1265                1270                1275                1280
Asn Val Thr Ala Ser Pro Ser Met Asp Gly Leu Leu Ala Gly Pro Thr
                1285                1290                1295
Met Pro Gln Ala Pro Pro Gln Gln Phe Pro Tyr Gln Pro Asn Tyr Gly
            1300                1305                1310
Met Gly Gln Gln Pro Asp Pro Ala Phe Gly Arg Val Ser Ser Pro Pro
        1315                1320                1325
Asn Ala Met Met Ser Ser Arg Met Gly Pro Ser Gln Asn Pro Met Met
    1330                1335                1340
Gln His Pro Gln Ala Ala Ser Ile Tyr Gln Ser Ser Glu Met Lys Gly
1345                1350                1355                1360
Trp Pro Ser Gly Asn Leu Ala Arg Asn Ser Ser Phe Ser Gln Gln Gln
                1365                1370                1375
Phe Ala His Gln Gly Asn Pro Ala Val Tyr Ser Met Val His Met Asn
            1380                1385                1390
Gly Ser Ser Gly His Met Gly Gln Met Asn Met Asn Pro Met Pro Met
        1395                1400                1405
Ser Gly Met Pro Met Gly Pro Asp Gln Lys Tyr Cys
    1410                1415                1420

<210> 350
<211> 1424
<212> PRT
<213> Homo sapiens

<400> 350
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser
                325                 330                 335
Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe
            340                 345                 350
Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe
        355                 360                 365
Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly
    370                 375                 380
Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly
385                 390                 395                 400
Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala
                405                 410                 415
Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg
            420                 425                 430
Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met
        435                 440                 445
Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser
    450                 455                 460
Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile
465                 470                 475                 480
Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln
                485                 490                 495
Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn
            500                 505                 510
Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala
        515                 520                 525
Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro
    530                 535                 540
Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser
545                 550                 555                 560
Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp
                565                 570                 575
Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His
            580                 585                 590
Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn
        595                 600                 605
Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu
    610                 615                 620
Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser
625                 630                 635                 640
Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro
                645                 650                 655
Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn
            660                 665                 670
Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu
        675                 680                 685
Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu
    690                 695                 700
Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn
705                 710                 715                 720
Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala
                725                 730                 735
Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser
            740                 745                 750
Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln
        755                 760                 765
Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys
    770                 775                 780
Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu
785                 790                 795                 800
Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser
                805                 810                 815
Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln
            820                 825                 830
Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile
        835                 840                 845
Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val
    850                 855                 860
Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro
865                 870                 875                 880
Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu
                885                 890                 895
Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr
            900                 905                 910
Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly
        915                 920                 925
Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp
    930                 935                 940
Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr
945                 950                 955                 960
Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln
                965                 970                 975
Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly
            980                 985                 990
Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly
        995                 1000                1005
Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr
    1010                1015                1020
Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro
1025                1030                1035                1040
Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln
                1045                1050                1055
Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile
            1060                1065                1070
Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu
        1075                1080                1085
Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met
    1090                1095                1100
Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro
1105                1110                1115                1120
Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn
                1125                1130                1135
Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly
            1140                1145                1150
Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys
        1155                1160                1165
Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu
    1170                1175                1180
Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala
1185                1190                1195                1200
Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Val Ser Ser
                1205                1210                1215
Gln Gln Gly Phe Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu
            1220                1225                1230
Leu Leu Ser His His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Thr Gln Ala Phe
1265                1270                1275                1280
Ser Pro Pro Pro Asn Val Thr Ala Ser Pro Ser Met Asp Gly Leu Leu
                1285                1290                1295
Ala Gly Pro Thr Met Pro Gln Ala Pro Pro Gln Gln Phe Pro Tyr Gln
            1300                1305                1310
Pro Asn Tyr Gly Met Gly Gln Gln Pro Asp Pro Ala Phe Gly Arg Val
        1315                1320                1325
Ser Ser Pro Pro Asn Ala Met Met Ser Ser Arg Met Gly Pro Ser Gln
    1330                1335                1340
Asn Pro Met Met Gln His Pro Gln Ala Ala Ser Ile Tyr Gln Ser Ser
1345                1350                1355                1360
Glu Met Lys Gly Trp Pro Ser Gly Asn Leu Ala Arg Asn Ser Ser Phe
                1365                1370                1375
Ser Gln Gln Gln Phe Ala His Gln Gly Asn Pro Ala Val Tyr Ser Met
            1380                1385                1390
Val His Met Asn Gly Ser Ser Gly His Met Gly Gln Met Asn Met Asn
        1395                1400                1405
Pro Met Pro Met Ser Gly Met Pro Met Gly Pro Asp Gln Lys Tyr Cys
    1410                1415                1420

<210> 351
<211> 1412
<212> PRT
<213> Homo sapiens

<400> 351
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Val Thr Ser Asp Gly Ile Phe Ser Pro Thr Ala Tyr Leu Asn Gly
                325                 330                 335
His Ala Glu Thr Pro Val Tyr Arg Phe Ser Leu Ala Asp Gly Thr Ile
            340                 345                 350
Val Thr Ala Gln Thr Lys Ser Lys Leu Phe Arg Asn Pro Val Thr Asn
        355                 360                 365
Asp Arg His Gly Phe Val Ser Thr His Phe Leu Gln Arg Glu Gln Asn
    370                 375                 380
Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly Gln Gly Ile Arg Pro Pro
385                 390                 395                 400
Met Ala Gly Cys Asn Ser Ser Val Gly Gly Met Ser Met Ser Pro Asn
                405                 410                 415
Gln Gly Leu Gln Met Pro Ser Ser Arg Ala Tyr Gly Leu Ala Asp Pro
            420                 425                 430
Ser Thr Thr Gly Gln Met Ser Gly Ala Arg Tyr Gly Gly Ser Ser Asn
        435                 440                 445
Ile Ala Ser Leu Thr Pro Gly Pro Gly Met Gln Ser Pro Ser Ser Tyr
    450                 455                 460
Gln Asn Asn Asn Tyr Arg Leu Asn Met Ser Ser Pro Pro His Gly Ser
465                 470                 475                 480
Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile Met Ile Ser Pro Arg Asn
                485                 490                 495
Arg Gly Ser Pro Lys Ile Ala Ser His Gln Phe Ser Pro Val Ala Gly
            500                 505                 510
Val His Ser Pro Met Ala Ser Ser Gly Asn Thr Gly Asn His Ser Phe
        515                 520                 525
Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala Ile Ser Glu Gly Val Gly
    530                 535                 540
Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro Gly Pro Lys Leu Asp Asn
545                 550                 555                 560
Ser Pro Asn Met Asn Ile Thr Gln Pro Ser Lys Val Ser Asn Gln Asp
                565                 570                 575
Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp Gln Asn Pro Val Glu Ser
            580                 585                 590
Ser Met Cys Gln Ser Asn Ser Arg Asp His Leu Ser Asp Lys Glu Ser
        595                 600                 605
Lys Glu Ser Ser Val Glu Gly Ala Glu Asn Gln Arg Gly Pro Leu Glu
    610                 615                 620
Ser Lys Gly His Lys Lys Leu Leu Gln Leu Leu Thr Cys Ser Ser Asp
625                 630                 635                 640
Asp Arg Gly His Ser Ser Leu Thr Asn Ser Pro Leu Asp Ser Ser Cys
                645                 650                 655
Lys Glu Ser Ser Val Ser Val Thr Ser Pro Ser Gly Val Ser Ser Ser
            660                 665                 670
Thr Ser Gly Gly Val Ser Ser Thr Ser Asn Met His Gly Ser Leu Leu
        675                 680                 685
Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln Asn Gly Asn Ser
    690                 695                 700
Pro Ala Glu Val Ala Lys Ile Thr Ala Glu Ala Thr Gly Lys Asp Thr
705                 710                 715                 720
Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn Val Val Lys Gln Glu Gln
                725                 730                 735
Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu
            740                 745                 750
Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser Lys Glu Leu Gln Pro Gln
        755                 760                 765
Val Glu Gly Val Asp Asn Lys Met Ser Gln Cys Thr Ser Ser Thr Ile
    770                 775                 780
Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys Ile Lys Thr Glu Thr Ser
785                 790                 795                 800
Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu Asp Ala Ile Leu Gly Asp
                805                 810                 815
Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser Ile Ser Ser Asn Gly Ser
            820                 825                 830
His Leu Gly Thr Lys Gln Gln Val Phe Gln Gly Thr Asn Ser Leu Gly
        835                 840                 845
Leu Lys Ser Ser Gln Ser Val Gln Ser Ile Arg Pro Pro Tyr Asn Arg
    850                 855                 860
Ala Val Ser Leu Asp Ser Pro Val Ser Val Gly Ser Ser Pro Pro Val
865                 870                 875                 880
Lys Asn Ile Ser Ala Phe Pro Met Leu Pro Lys Gln Pro Met Leu Gly
                885                 890                 895
Gly Asn Pro Arg Met Met Asp Ser Gln Glu Asn Tyr Gly Ser Ser Met
            900                 905                 910
Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly Arg Met Glu Pro Met
        915                 920                 925
Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp Tyr Asn Thr Ser Leu
    930                 935                 940
Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr Leu Pro Leu Arg Ser
945                 950                 955                 960
Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln Gln Gln Gln Gln Met
                965                 970                 975
Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly Met Gly Ala Asn Pro
            980                 985                 990
Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly Ser Trp Pro Asp Gly
        995                 1000                1005
Met Leu Ser Met Glu Gln Val Ser His Gly Thr Gln Asn Arg Pro Leu
    1010                1015                1020
Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro Pro Ser Asn Leu Glu
1025                1030                1035                1040
Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln Leu His Thr Leu Leu
                1045                1050                1055
Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile Asp Arg Ala Leu Gly
            1060                1065                1070
Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu Glu Pro Lys Gln Asp
        1075                1080                1085
Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met Asp Gln Lys Ala Gly
    1090                1095                1100
Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro Pro Met Gln Gly Gly
1105                1110                1115                1120
Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn Ser Met Met Asn Gln
                1125                1130                1135
Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly Met His Pro Arg Ala
            1140                1145                1150
Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys Gln Leu Arg Met Gln
        1155                1160                1165
Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu Asn Gln Ser Arg Gln
    1170                1175                1180
Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala Gly Gly Ala Ala Val
1185                1190                1195                1200
Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe Leu Asn Ala Gln Met
                1205                1210                1215
Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His His Phe Arg Gln Gln
            1220                1225                1230
Arg Val Ala Met Met Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Thr Gln Ala Phe Ser Pro Pro Pro Asn Val Thr Ala Ser Pro Ser Met
1265                1270                1275                1280
Asp Gly Leu Leu Ala Gly Pro Thr Met Pro Gln Ala Pro Pro Gln Gln
                1285                1290                1295
Phe Pro Tyr Gln Pro Asn Tyr Gly Met Gly Gln Gln Pro Asp Pro Ala
            1300                1305                1310
Phe Gly Arg Val Ser Ser Pro Pro Asn Ala Met Met Ser Ser Arg Met
        1315                1320                1325
Gly Pro Ser Gln Asn Pro Met Met Gln His Pro Gln Ala Ala Ser Ile
    1330                1335                1340
Tyr Gln Ser Ser Glu Met Lys Gly Trp Pro Ser Gly Asn Leu Ala Arg
1345                1350                1355                1360
Asn Ser Ser Phe Ser Gln Gln Gln Phe Ala His Gln Gly Asn Pro Ala
                1365                1370                1375
Val Tyr Ser Met Val His Met Asn Gly Ser Ser Gly His Met Gly Gln
            1380                1385                1390
Met Asn Met Asn Pro Met Pro Met Ser Gly Met Pro Met Gly Pro Asp
        1395                1400                1405
Gln Lys Tyr Cys
    1410

<210> 352
<211> 1412
<212> PRT
<213> Homo sapiens

<400> 352
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Val Thr Ser Asp Gly Ile Phe Ser Pro Thr Ala Tyr Leu Asn Gly
                325                 330                 335
His Ala Glu Thr Pro Val Tyr Arg Phe Ser Leu Ala Asp Gly Thr Ile
            340                 345                 350
Val Thr Ala Gln Thr Lys Ser Lys Leu Phe Arg Asn Pro Val Thr Asn
        355                 360                 365
Asp Arg His Gly Phe Val Ser Thr His Phe Leu Gln Arg Glu Gln Asn
    370                 375                 380
Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly Gln Gly Ile Arg Pro Pro
385                 390                 395                 400
Met Ala Gly Cys Asn Ser Ser Val Gly Gly Met Ser Met Ser Pro Asn
                405                 410                 415
Gln Gly Leu Gln Met Pro Ser Ser Arg Ala Tyr Gly Leu Ala Asp Pro
            420                 425                 430
Ser Thr Thr Gly Gln Met Ser Gly Ala Arg Tyr Gly Gly Ser Ser Asn
        435                 440                 445
Ile Ala Ser Leu Thr Pro Gly Pro Gly Met Gln Ser Pro Ser Ser Tyr
    450                 455                 460
Gln Asn Asn Asn Tyr Arg Leu Asn Met Ser Ser Pro Pro His Gly Ser
465                 470                 475                 480
Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile Met Ile Ser Pro Arg Asn
                485                 490                 495
Arg Gly Ser Pro Lys Ile Ala Ser His Gln Phe Ser Pro Val Ala Gly
            500                 505                 510
Val His Ser Pro Met Ala Ser Ser Gly Asn Thr Gly Asn His Ser Phe
        515                 520                 525
Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala Ile Ser Glu Gly Val Gly
    530                 535                 540
Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro Gly Pro Lys Leu Asp Asn
545                 550                 555                 560
Ser Pro Asn Met Asn Ile Thr Gln Pro Ser Lys Val Ser Asn Gln Asp
                565                 570                 575
Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp Gln Asn Pro Val Glu Ser
            580                 585                 590
Ser Met Cys Gln Ser Asn Ser Arg Asp His Leu Ser Asp Lys Glu Ser
        595                 600                 605
Lys Glu Ser Ser Val Glu Gly Ala Glu Asn Gln Arg Gly Pro Leu Glu
    610                 615                 620
Ser Lys Gly His Lys Lys Leu Leu Gln Leu Leu Thr Cys Ser Ser Asp
625                 630                 635                 640
Asp Arg Gly His Ser Ser Leu Thr Asn Ser Pro Leu Asp Ser Ser Cys
                645                 650                 655
Lys Glu Ser Ser Val Ser Val Thr Ser Pro Ser Gly Val Ser Ser Ser
            660                 665                 670
Thr Ser Gly Gly Val Ser Ser Thr Ser Asn Met His Gly Ser Leu Leu
        675                 680                 685
Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln Asn Gly Asn Ser
    690                 695                 700
Pro Ala Glu Val Ala Lys Ile Thr Ala Glu Ala Thr Gly Lys Asp Thr
705                 710                 715                 720
Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn Val Val Lys Gln Glu Gln
                725                 730                 735
Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu
            740                 745                 750
Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser Lys Glu Leu Gln Pro Gln
        755                 760                 765
Val Glu Gly Val Asp Asn Lys Met Ser Gln Cys Thr Ser Ser Thr Ile
    770                 775                 780
Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys Ile Lys Thr Glu Thr Ser
785                 790                 795                 800
Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu Asp Ala Ile Leu Gly Asp
                805                 810                 815
Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser Ile Ser Ser Asn Gly Ser
            820                 825                 830
His Leu Gly Thr Lys Gln Gln Val Phe Gln Gly Thr Asn Ser Leu Gly
        835                 840                 845
Leu Lys Ser Ser Gln Ser Val Gln Ser Ile Arg Pro Pro Tyr Asn Arg
    850                 855                 860
Ala Val Ser Leu Asp Ser Pro Val Ser Val Gly Ser Ser Pro Pro Val
865                 870                 875                 880
Lys Asn Ile Ser Ala Phe Pro Met Leu Pro Lys Gln Pro Met Leu Gly
                885                 890                 895
Gly Asn Pro Arg Met Met Asp Ser Gln Glu Asn Tyr Gly Ser Ser Met
            900                 905                 910
Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly Arg Met Glu Pro Met
        915                 920                 925
Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp Tyr Asn Thr Ser Leu
    930                 935                 940
Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr Leu Pro Leu Arg Ser
945                 950                 955                 960
Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln Gln Gln Gln Gln Met
                965                 970                 975
Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly Met Gly Ala Asn Pro
            980                 985                 990
Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly Ser Trp Pro Asp Gly
        995                 1000                1005
Met Leu Ser Met Glu Gln Val Ser His Gly Thr Gln Asn Arg Pro Leu
    1010                1015                1020
Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro Pro Ser Asn Leu Glu
1025                1030                1035                1040
Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln Leu His Thr Leu Leu
                1045                1050                1055
Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile Asp Arg Ala Leu Gly
            1060                1065                1070
Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu Glu Pro Lys Gln Asp
        1075                1080                1085
Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met Asp Gln Lys Ala Gly
    1090                1095                1100
Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro Pro Met Gln Gly Gly
1105                1110                1115                1120
Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn Ser Met Met Asn Gln
                1125                1130                1135
Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly Met His Pro Arg Ala
            1140                1145                1150
Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys Gln Leu Arg Met Gln
        1155                1160                1165
Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu Asn Gln Ser Arg Gln
    1170                1175                1180
Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala Gly Gly Ala Ala Val
1185                1190                1195                1200
Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe Leu Asn Ala Gln Met
                1205                1210                1215
Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His His Phe Arg Gln Gln
            1220                1225                1230
Arg Val Ala Met Met Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Thr Gln Ala Phe Ser Pro Pro Pro Asn Val Thr Ala Ser Pro Ser Met
1265                1270                1275                1280
Asp Gly Leu Leu Ala Gly Pro Thr Met Pro Gln Ala Pro Pro Gln Gln
                1285                1290                1295
Phe Pro Tyr Gln Pro Asn Tyr Gly Met Gly Gln Gln Pro Asp Pro Ala
            1300                1305                1310
Phe Gly Arg Val Ser Ser Pro Pro Asn Ala Met Met Ser Ser Arg Met
        1315                1320                1325
Gly Pro Ser Gln Asn Pro Met Met Gln His Pro Gln Ala Ala Ser Ile
    1330                1335                1340
Tyr Gln Ser Ser Glu Met Lys Gly Trp Pro Ser Gly Asn Leu Ala Arg
1345                1350                1355                1360
Asn Ser Ser Phe Ser Gln Gln Gln Phe Ala His Gln Gly Asn Pro Ala
                1365                1370                1375
Val Tyr Ser Met Val His Met Asn Gly Ser Ser Gly His Met Gly Gln
            1380                1385                1390
Met Asn Met Asn Pro Met Pro Met Ser Gly Met Pro Met Gly Pro Asp
        1395                1400                1405
Gln Lys Tyr Cys
    1410

<210> 353
<211> 1420
<212> PRT
<213> Homo sapiens

<400> 353
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser
                325                 330                 335
Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe
            340                 345                 350
Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe
        355                 360                 365
Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly
    370                 375                 380
Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly
385                 390                 395                 400
Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala
                405                 410                 415
Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg
            420                 425                 430
Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met
        435                 440                 445
Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser
    450                 455                 460
Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile
465                 470                 475                 480
Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln
                485                 490                 495
Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn
            500                 505                 510
Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala
        515                 520                 525
Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro
    530                 535                 540
Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser
545                 550                 555                 560
Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp
                565                 570                 575
Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His
            580                 585                 590
Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn
        595                 600                 605
Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu
    610                 615                 620
Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser
625                 630                 635                 640
Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro
                645                 650                 655
Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn
            660                 665                 670
Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu
        675                 680                 685
Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu
    690                 695                 700
Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn
705                 710                 715                 720
Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala
                725                 730                 735
Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser
            740                 745                 750
Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln
        755                 760                 765
Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys
    770                 775                 780
Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu
785                 790                 795                 800
Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser
                805                 810                 815
Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln
            820                 825                 830
Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile
        835                 840                 845
Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val
    850                 855                 860
Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro
865                 870                 875                 880
Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu
                885                 890                 895
Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr
            900                 905                 910
Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly
        915                 920                 925
Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp
    930                 935                 940
Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr
945                 950                 955                 960
Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln
                965                 970                 975
Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly
            980                 985                 990
Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly
        995                 1000                1005
Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr
    1010                1015                1020
Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro
1025                1030                1035                1040
Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln
                1045                1050                1055
Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile
            1060                1065                1070
Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu
        1075                1080                1085
Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met
    1090                1095                1100
Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro
1105                1110                1115                1120
Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn
                1125                1130                1135
Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly
            1140                1145                1150
Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys
        1155                1160                1165
Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu
    1170                1175                1180
Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala
1185                1190                1195                1200
Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe
                1205                1210                1215
Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His
            1220                1225                1230
His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln Gln Gln Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Gln Gln Gln Gln Gln Gln Gln Gln Thr Gln Ala Phe Ser Pro Pro Pro
1265                1270                1275                1280
Asn Val Thr Ala Ser Pro Ser Met Asp Gly Leu Leu Ala Gly Pro Thr
                1285                1290                1295
Met Pro Gln Ala Pro Pro Gln Gln Phe Pro Tyr Gln Pro Asn Tyr Gly
            1300                1305                1310
Met Gly Gln Gln Pro Asp Pro Ala Phe Gly Arg Val Ser Ser Pro Pro
        1315                1320                1325
Asn Ala Met Met Ser Ser Arg Met Gly Pro Ser Gln Asn Pro Met Met
    1330                1335                1340
Gln His Pro Gln Ala Ala Ser Ile Tyr Gln Ser Ser Glu Met Lys Gly
1345                1350                1355                1360
Trp Pro Ser Gly Asn Leu Ala Arg Asn Ser Ser Phe Ser Gln Gln Gln
                1365                1370                1375
Phe Ala His Gln Gly Asn Pro Ala Val Tyr Ser Met Val His Met Asn
            1380                1385                1390
Gly Ser Ser Gly His Met Gly Gln Met Asn Met Asn Pro Met Pro Met
        1395                1400                1405
Ser Gly Met Pro Met Gly Pro Asp Gln Lys Tyr Cys
    1410                1415                1420

<210> 354
<211> 951
<212> PRT
<213> Homo sapiens

<400> 354
Cys Ile Gln Arg Phe Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln
 1               5                  10                  15
Lys Arg His Tyr Gln Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro
            20                  25                  30
Val Tyr Arg Phe Ser Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr
        35                  40                  45
Lys Ser Lys Leu Phe Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe
    50                  55                  60
Val Ser Thr His Phe Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn
65                  70                  75                  80
Pro Asn Pro Val Gly Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn
                85                  90                  95
Ser Ser Val Gly Gly Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met
            100                 105                 110
Pro Ser Ser Arg Ala Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln
        115                 120                 125
Met Ser Gly Ala Arg Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr
    130                 135                 140
Pro Gly Pro Gly Met Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr
145                 150                 155                 160
Gly Leu Asn Met Ser Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro
                165                 170                 175
Asn Gln Gln Asn Ile Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys
            180                 185                 190
Ile Ala Ser His Gln Phe Ser Pro Val Ala Gly Val His Ser Pro Met
        195                 200                 205
Ala Ser Ser Gly Asn Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu
    210                 215                 220
Ser Ala Leu Gln Ala Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser
225                 230                 235                 240
Thr Leu Ser Ser Pro Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn
                245                 250                 255
Ile Thr Gln Pro Ser Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu
            260                 265                 270
Gly Phe Tyr Cys Asp Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser
        275                 280                 285
Asn Ser Arg Asp His Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val
    290                 295                 300
Glu Gly Ala Glu Asn Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys
305                 310                 315                 320
Lys Leu Leu Gln Leu Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser
                325                 330                 335
Ser Leu Thr Asn Ser Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val
            340                 345                 350
Ser Val Thr Ser Pro Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val
        355                 360                 365
Ser Ser Thr Ser Asn Met His Gly Ser Leu Leu Gln Glu Lys His Arg
    370                 375                 380
Ile Leu His Lys Leu Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala
385                 390                 395                 400
Lys Ile Thr Ala Glu Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser
                405                 410                 415
Cys Gly Asp Gly Asn Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys
            420                 425                 430
Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro
        435                 440                 445
Ser Asp Ala Leu Ser Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp
    450                 455                 460
Asn Lys Met Ser Gln Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln
465                 470                 475                 480
Glu Lys Asp Pro Lys Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly
                485                 490                 495
Asp Leu Asp Asn Leu Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp
            500                 505                 510
Phe Tyr Asn Asn Ser Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys
        515                 520                 525
Gln Gln Val Phe Gln Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln
    530                 535                 540
Ser Val Gln Ser Ile Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp
545                 550                 555                 560
Ser Pro Val Ser Val Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala
                565                 570                 575
Phe Pro Met Leu Pro Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met
            580                 585                 590
Met Asp Ser Gln Glu Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg
        595                 600                 605
Asn Val Thr Val Thr Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro
    610                 615                 620
Asn Ser Lys Ala Gly Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly
625                 630                 635                 640
Arg Pro Gly Gly Asp Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly
                645                 650                 655
Gly Ser Ile Pro Thr Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala
            660                 665                 670
Arg Pro Val Leu Gln Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly
        675                 680                 685
Glu Ile Pro Met Gly Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala
    690                 695                 700
Ser Asn Gln Leu Gly Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln
705                 710                 715                 720
Val Ser His Gly Thr Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp
                725                 730                 735
Asp Leu Val Gly Pro Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg
            740                 745                 750
Ala Leu Leu Asp Gln Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr
        755                 760                 765
Gly Leu Glu Glu Ile Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn
    770                 775                 780
Gln Gly Gln Ala Leu Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu
785                 790                 795                 800
Ala Ala Val Met Met Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr
                805                 810                 815
Pro Ala Gln Gly Pro Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln
            820                 825                 830
Ser Pro Ser Phe Asn Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn
        835                 840                 845
Phe Pro Leu Gln Gly Met His Pro Arg Ala Asn Ile Met Arg Pro Arg
    850                 855                 860
Thr Asn Thr Pro Lys Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln
865                 870                 875                 880
Gly Gln Gln Phe Leu Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met
                885                 890                 895
Glu Asn Pro Thr Ala Gly Gly Ala Ala Val Met Arg Pro Met Met Gln
            900                 905                 910
Pro Gln Gln Gly Phe Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg
        915                 920                 925
Glu Leu Leu Ser His His Phe Arg Gln Gln Arg Val Ala Met Met Met
    930                 935                 940
Gln Gln Gln Gln Gln Gln Gln
945                 950

<210> 355
<211> 1522
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(1522)
<223> Xaa = Any Amino Acid

<400> 355
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser
                325                 330                 335
Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe
            340                 345                 350
Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe
        355                 360                 365
Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly
    370                 375                 380
Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly
385                 390                 395                 400
Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala
                405                 410                 415
Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg
            420                 425                 430
Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met
        435                 440                 445
Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser
    450                 455                 460
Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile
465                 470                 475                 480
Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln
                485                 490                 495
Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn
            500                 505                 510
Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala
        515                 520                 525
Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro
    530                 535                 540
Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser
545                 550                 555                 560
Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp
                565                 570                 575
Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His
            580                 585                 590
Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn
        595                 600                 605
Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu
    610                 615                 620
Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser
625                 630                 635                 640
Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro
                645                 650                 655
Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn
            660                 665                 670
Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu
        675                 680                 685
Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu
    690                 695                 700
Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn
705                 710                 715                 720
Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala
                725                 730                 735
Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser
            740                 745                 750
Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln
        755                 760                 765
Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys
    770                 775                 780
Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu
785                 790                 795                 800
Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser
                805                 810                 815
Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln
            820                 825                 830
Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile
        835                 840                 845
Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val
    850                 855                 860
Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro
865                 870                 875                 880
Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu
                885                 890                 895
Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr
            900                 905                 910
Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly
        915                 920                 925
Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp
    930                 935                 940
Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr
945                 950                 955                 960
Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln
                965                 970                 975
Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly
            980                 985                 990
Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly
        995                 1000                1005
Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr
    1010                1015                1020
Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro
1025                1030                1035                1040
Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln
                1045                1050                1055
Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile
            1060                1065                1070
Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu
        1075                1080                1085
Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met
    1090                1095                1100
Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro
1105                1110                1115                1120
Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn
                1125                1130                1135
Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly
            1140                1145                1150
Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys
        1155                1160                1165
Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu
    1170                1175                1180
Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala
1185                1190                1195                1200
Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Val Ser Ser
                1205                1210                1215
Gln Gly Phe Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu Leu
            1220                1225                1230
Leu Ser His His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Thr Gln Ala Phe Ser
1265                1270                1275                1280
Pro Pro Pro Asn Val Thr Ala Ser Pro Ser Met Asp Gly Leu Leu Ala
                1285                1290                1295
Gly Pro Thr Met Pro Gln Ala Pro Pro Gln Gln Phe Pro Tyr Gln Pro
            1300                1305                1310
Asn Tyr Gly Met Gly Gln Gln Pro Asp Pro Ala Phe Gly Arg Val Ser
        1315                1320                1325
Ser Pro Pro Asn Ala Met Met Ser Ser Arg Met Gly Pro Ser Gln Asn
    1330                1335                1340
Pro Met Met Gln His Pro Gln Ala Ala Ser Ile Tyr Gln Ser Ser Glu
1345                1350                1355                1360
Met Lys Gly Trp Pro Ser Gly Asn Leu Ala Arg Asn Ser Ser Phe Ser
                1365                1370                1375
Gln Gln Gln Phe Ala His Gln Gly Asn Pro Ala Val Tyr Ser Met Val
            1380                1385                1390
His Met Asn Gly Ser Ser Gly His Met Gly Gln Met Asn Met Asn Pro
        1395                1400                1405
Met Pro Met Ser Gly Met Pro Met Gly Pro Asp Gln Lys Tyr Cys Xaa
    1410                1415                1420
His Leu Cys Thr Arg Thr Ser Xaa Gly Asn His Cys Thr Asn Asp Thr
1425                1430                1435                1440
Ala Leu Gly Leu Leu Gly Arg Asn His Cys Ser Arg His Pro Ser Trp
                1445                1450                1455
Lys Lys Gly Pro Ala Leu Ser Ser Ile Lys Gly Ile Leu Ser Asp Val
            1460                1465                1470
Ile Xaa Ala Gly Leu Asp Phe Lys Pro Lys Gly Asn Ile Tyr Val Phe
        1475                1480                1485
Phe Pro Pro Pro Ala Val Tyr His Gly Val Gln Asn Arg Asn Val Phe
    1490                1495                1500
Trp His Ser Thr Ser Xaa Gly Tyr Asn Ser Gly Asp Met Glu Cys Tyr
1505                1510                1515                1520
Xaa Ser


<210> 356
<211> 1412
<212> PRT
<213> Homo sapiens

<400> 356
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Val Thr Ser Asp Gly Ile Phe Ser Pro Thr Ala Tyr Leu Asn Gly
                325                 330                 335
His Ala Glu Thr Pro Val Tyr Arg Phe Ser Leu Ala Asp Gly Thr Ile
            340                 345                 350
Val Thr Ala Gln Thr Lys Ser Lys Leu Phe Arg Asn Pro Val Thr Asn
        355                 360                 365
Asp Arg His Gly Phe Val Ser Thr His Phe Leu Gln Arg Glu Gln Asn
    370                 375                 380
Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly Gln Gly Ile Arg Pro Pro
385                 390                 395                 400
Met Ala Gly Cys Asn Ser Ser Val Gly Gly Met Ser Met Ser Pro Asn
                405                 410                 415
Gln Gly Leu Gln Met Pro Ser Ser Arg Ala Tyr Gly Leu Ala Asp Pro
            420                 425                 430
Ser Thr Thr Gly Gln Met Ser Gly Ala Arg Tyr Gly Gly Ser Ser Asn
        435                 440                 445
Ile Ala Ser Leu Thr Pro Gly Pro Gly Met Gln Ser Pro Ser Ser Tyr
    450                 455                 460
Gln Asn Asn Asn Tyr Arg Leu Asn Met Ser Ser Pro Pro His Gly Ser
465                 470                 475                 480
Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile Met Ile Ser Pro Arg Asn
                485                 490                 495
Arg Gly Ser Pro Lys Ile Ala Ser His Gln Phe Ser Pro Val Ala Gly
            500                 505                 510
Val His Ser Pro Met Ala Ser Ser Gly Asn Thr Gly Asn His Ser Phe
        515                 520                 525
Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala Ile Ser Glu Gly Val Gly
    530                 535                 540
Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro Gly Pro Lys Leu Asp Asn
545                 550                 555                 560
Ser Pro Asn Met Asn Ile Thr Gln Pro Ser Lys Val Ser Asn Gln Asp
                565                 570                 575
Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp Gln Asn Pro Val Glu Ser
            580                 585                 590
Ser Met Cys Gln Ser Asn Ser Arg Asp His Leu Ser Asp Lys Glu Ser
        595                 600                 605
Lys Glu Ser Ser Val Glu Gly Ala Glu Asn Gln Arg Gly Pro Leu Glu
    610                 615                 620
Ser Lys Gly His Lys Lys Leu Leu Gln Leu Leu Thr Cys Ser Ser Asp
625                 630                 635                 640
Asp Arg Gly His Ser Ser Leu Thr Asn Ser Pro Leu Asp Ser Ser Cys
                645                 650                 655
Lys Glu Ser Ser Val Ser Val Thr Ser Pro Ser Gly Val Ser Ser Ser
            660                 665                 670
Thr Ser Gly Gly Val Ser Ser Thr Ser Asn Met His Gly Ser Leu Leu
        675                 680                 685
Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln Asn Gly Asn Ser
    690                 695                 700
Pro Ala Glu Val Ala Lys Ile Thr Ala Glu Ala Thr Gly Lys Asp Thr
705                 710                 715                 720
Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn Val Val Lys Gln Glu Gln
                725                 730                 735
Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu
            740                 745                 750
Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser Lys Glu Leu Gln Pro Gln
        755                 760                 765
Val Glu Gly Val Asp Asn Lys Met Ser Gln Cys Thr Ser Ser Thr Ile
    770                 775                 780
Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys Ile Lys Thr Glu Thr Ser
785                 790                 795                 800
Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu Asp Ala Ile Leu Gly Asp
                805                 810                 815
Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser Ile Ser Ser Asn Gly Ser
            820                 825                 830
His Leu Gly Thr Lys Gln Gln Val Phe Gln Gly Thr Asn Ser Leu Gly
        835                 840                 845
Leu Lys Ser Ser Gln Ser Val Gln Ser Ile Arg Pro Pro Tyr Asn Arg
    850                 855                 860
Ala Val Ser Leu Asp Ser Pro Val Ser Val Gly Ser Ser Pro Pro Val
865                 870                 875                 880
Lys Asn Ile Ser Ala Phe Pro Met Leu Pro Lys Gln Pro Met Leu Gly
                885                 890                 895
Gly Asn Pro Arg Met Met Asp Ser Gln Glu Asn Tyr Gly Ser Ser Met
            900                 905                 910
Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly Arg Met Glu Pro Met
        915                 920                 925
Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp Tyr Asn Thr Ser Leu
    930                 935                 940
Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr Leu Pro Leu Arg Ser
945                 950                 955                 960
Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln Gln Gln Gln Gln Met
                965                 970                 975
Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly Met Gly Ala Asn Pro
            980                 985                 990
Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly Ser Trp Pro Asp Gly
        995                 1000                1005
Met Leu Ser Met Glu Gln Val Ser His Gly Thr Gln Asn Arg Pro Leu
    1010                1015                1020
Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro Pro Ser Asn Leu Glu
1025                1030                1035                1040
Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln Leu His Thr Leu Leu
                1045                1050                1055
Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile Asp Arg Ala Leu Gly
            1060                1065                1070
Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu Glu Pro Lys Gln Asp
        1075                1080                1085
Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met Asp Gln Lys Ala Gly
    1090                1095                1100
Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro Pro Met Gln Gly Gly
1105                1110                1115                1120
Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn Ser Met Met Asn Gln
                1125                1130                1135
Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly Met His Pro Arg Ala
            1140                1145                1150
Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys Gln Leu Arg Met Gln
        1155                1160                1165
Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu Asn Gln Ser Arg Gln
    1170                1175                1180
Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala Gly Gly Ala Ala Val
1185                1190                1195                1200
Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe Leu Asn Ala Gln Met
                1205                1210                1215
Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His His Phe Arg Gln Gln
            1220                1225                1230
Arg Val Ala Met Met Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Thr Gln Ala Phe Ser Pro Pro Pro Asn Val Thr Ala Ser Pro Ser Met
1265                1270                1275                1280
Asp Gly Leu Leu Ala Gly Pro Thr Met Pro Gln Ala Pro Pro Gln Gln
                1285                1290                1295
Phe Pro Tyr Gln Pro Asn Tyr Gly Met Gly Gln Gln Pro Asp Pro Ala
            1300                1305                1310
Phe Gly Arg Val Ser Ser Pro Pro Asn Ala Met Met Ser Ser Arg Met
        1315                1320                1325
Gly Pro Ser Gln Asn Pro Met Met Gln His Pro Gln Ala Ala Ser Ile
    1330                1335                1340
Tyr Gln Ser Ser Glu Met Lys Gly Trp Pro Ser Gly Asn Leu Ala Arg
1345                1350                1355                1360
Asn Ser Ser Phe Ser Gln Gln Gln Phe Ala His Gln Gly Asn Pro Ala
                1365                1370                1375
Val Tyr Ser Met Val His Met Asn Gly Ser Ser Gly His Met Gly Gln
            1380                1385                1390
Met Asn Met Asn Pro Met Pro Met Ser Gly Met Pro Met Gly Pro Asp
        1395                1400                1405
Gln Lys Tyr Cys
    1410

<210> 357
<211> 1412
<212> PRT
<213> Homo sapiens

<400> 357
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Val Thr Ser Asp Gly Ile Phe Ser Pro Thr Ala Tyr Leu Asn Gly
                325                 330                 335
His Ala Glu Thr Pro Val Tyr Arg Phe Ser Leu Ala Asp Gly Thr Ile
            340                 345                 350
Val Thr Ala Gln Thr Lys Ser Lys Leu Phe Arg Asn Pro Val Thr Asn
        355                 360                 365
Asp Arg His Gly Phe Val Ser Thr His Phe Leu Gln Arg Glu Gln Asn
    370                 375                 380
Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly Gln Gly Ile Arg Pro Pro
385                 390                 395                 400
Met Ala Gly Cys Asn Ser Ser Val Gly Gly Met Ser Met Ser Pro Asn
                405                 410                 415
Gln Gly Leu Gln Met Pro Ser Ser Arg Ala Tyr Gly Leu Ala Asp Pro
            420                 425                 430
Ser Thr Thr Gly Gln Met Ser Gly Ala Arg Tyr Gly Gly Ser Ser Asn
        435                 440                 445
Ile Ala Ser Leu Thr Pro Gly Pro Gly Met Gln Ser Pro Ser Ser Tyr
    450                 455                 460
Gln Asn Asn Asn Tyr Arg Leu Asn Met Ser Ser Pro Pro His Gly Ser
465                 470                 475                 480
Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile Met Ile Ser Pro Arg Asn
                485                 490                 495
Arg Gly Ser Pro Lys Ile Ala Ser His Gln Phe Ser Pro Val Ala Gly
            500                 505                 510
Val His Ser Pro Met Ala Ser Ser Gly Asn Thr Gly Asn His Ser Phe
        515                 520                 525
Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala Ile Ser Glu Gly Val Gly
    530                 535                 540
Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro Gly Pro Lys Leu Asp Asn
545                 550                 555                 560
Ser Pro Asn Met Asn Ile Thr Gln Pro Ser Lys Val Ser Asn Gln Asp
                565                 570                 575
Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp Gln Asn Pro Val Glu Ser
            580                 585                 590
Ser Met Cys Gln Ser Asn Ser Arg Asp His Leu Ser Asp Lys Glu Ser
        595                 600                 605
Lys Glu Ser Ser Val Glu Gly Ala Glu Asn Gln Arg Gly Pro Leu Glu
    610                 615                 620
Ser Lys Gly His Lys Lys Leu Leu Gln Leu Leu Thr Cys Ser Ser Asp
625                 630                 635                 640
Asp Arg Gly His Ser Ser Leu Thr Asn Ser Pro Leu Asp Ser Ser Cys
                645                 650                 655
Lys Glu Ser Ser Val Ser Val Thr Ser Pro Ser Gly Val Ser Ser Ser
            660                 665                 670
Thr Ser Gly Gly Val Ser Ser Thr Ser Asn Met His Gly Ser Leu Leu
        675                 680                 685
Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln Asn Gly Asn Ser
    690                 695                 700
Pro Ala Glu Val Ala Lys Ile Thr Ala Glu Ala Thr Gly Lys Asp Thr
705                 710                 715                 720
Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn Val Val Lys Gln Glu Gln
                725                 730                 735
Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu
            740                 745                 750
Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser Lys Glu Leu Gln Pro Gln
        755                 760                 765
Val Glu Gly Val Asp Asn Lys Met Ser Gln Cys Thr Ser Ser Thr Ile
    770                 775                 780
Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys Ile Lys Thr Glu Thr Ser
785                 790                 795                 800
Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu Asp Ala Ile Leu Gly Asp
                805                 810                 815
Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser Ile Ser Ser Asn Gly Ser
            820                 825                 830
His Leu Gly Thr Lys Gln Gln Val Phe Gln Gly Thr Asn Ser Leu Gly
        835                 840                 845
Leu Lys Ser Ser Gln Ser Val Gln Ser Ile Arg Pro Pro Tyr Asn Arg
    850                 855                 860
Ala Val Ser Leu Asp Ser Pro Val Ser Val Gly Ser Ser Pro Pro Val
865                 870                 875                 880
Lys Asn Ile Ser Ala Phe Pro Met Leu Pro Lys Gln Pro Met Leu Gly
                885                 890                 895
Gly Asn Pro Arg Met Met Asp Ser Gln Glu Asn Tyr Gly Ser Ser Met
            900                 905                 910
Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly Arg Met Glu Pro Met
        915                 920                 925
Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp Tyr Asn Thr Ser Leu
    930                 935                 940
Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr Leu Pro Leu Arg Ser
945                 950                 955                 960
Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln Gln Gln Gln Gln Met
                965                 970                 975
Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly Met Gly Ala Asn Pro
            980                 985                 990
Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly Ser Trp Pro Asp Gly
        995                 1000                1005
Met Leu Ser Met Glu Gln Val Ser His Gly Thr Gln Asn Arg Pro Leu
    1010                1015                1020
Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro Pro Ser Asn Leu Glu
1025                1030                1035                1040
Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln Leu His Thr Leu Leu
                1045                1050                1055
Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile Asp Arg Ala Leu Gly
            1060                1065                1070
Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu Glu Pro Lys Gln Asp
        1075                1080                1085
Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met Asp Gln Lys Ala Gly
    1090                1095                1100
Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro Pro Met Gln Gly Gly
1105                1110                1115                1120
Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn Ser Met Met Asn Gln
                1125                1130                1135
Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly Met His Pro Arg Ala
            1140                1145                1150
Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys Gln Leu Arg Met Gln
        1155                1160                1165
Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu Asn Gln Ser Arg Gln
    1170                1175                1180
Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala Gly Gly Ala Ala Val
1185                1190                1195                1200
Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe Leu Asn Ala Gln Met
                1205                1210                1215
Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His His Phe Arg Gln Gln
            1220                1225                1230
Arg Val Ala Met Met Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Thr Gln Ala Phe Ser Pro Pro Pro Asn Val Thr Ala Ser Pro Ser Met
1265                1270                1275                1280
Asp Gly Leu Leu Ala Gly Pro Thr Met Pro Gln Ala Pro Pro Gln Gln
                1285                1290                1295
Phe Pro Tyr Gln Pro Asn Tyr Gly Met Gly Gln Gln Pro Asp Pro Ala
            1300                1305                1310
Phe Gly Arg Val Ser Ser Pro Pro Asn Ala Met Met Ser Ser Arg Met
        1315                1320                1325
Gly Pro Ser Gln Asn Pro Met Met Gln His Pro Gln Ala Ala Ser Ile
    1330                1335                1340
Tyr Gln Ser Ser Glu Met Lys Gly Trp Pro Ser Gly Asn Leu Ala Arg
1345                1350                1355                1360
Asn Ser Ser Phe Ser Gln Gln Gln Phe Ala His Gln Gly Asn Pro Ala
                1365                1370                1375
Val Tyr Ser Met Val His Met Asn Gly Ser Ser Gly His Met Gly Gln
            1380                1385                1390
Met Asn Met Asn Pro Met Pro Met Ser Gly Met Pro Met Gly Pro Asp
        1395                1400                1405
Gln Lys Tyr Cys
    1410

<210> 358
<211> 1420
<212> PRT
<213> Homo sapiens

<400> 358
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser
                325                 330                 335
Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe
            340                 345                 350
Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe
        355                 360                 365
Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly
    370                 375                 380
Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly
385                 390                 395                 400
Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala
                405                 410                 415
Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg
            420                 425                 430
Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met
        435                 440                 445
Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser
    450                 455                 460
Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile
465                 470                 475                 480
Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln
                485                 490                 495
Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn
            500                 505                 510
Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala
        515                 520                 525
Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro
    530                 535                 540
Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser
545                 550                 555                 560
Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp
                565                 570                 575
Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His
            580                 585                 590
Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn
        595                 600                 605
Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu
    610                 615                 620
Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser
625                 630                 635                 640
Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro
                645                 650                 655
Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn
            660                 665                 670
Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu
        675                 680                 685
Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu
    690                 695                 700
Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn
705                 710                 715                 720
Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala
                725                 730                 735
Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser
            740                 745                 750
Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln
        755                 760                 765
Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys
    770                 775                 780
Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu
785                 790                 795                 800
Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser
                805                 810                 815
Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln
            820                 825                 830
Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile
        835                 840                 845
Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val
    850                 855                 860
Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro
865                 870                 875                 880
Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu
                885                 890                 895
Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr
            900                 905                 910
Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly
        915                 920                 925
Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp
    930                 935                 940
Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr
945                 950                 955                 960
Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln
                965                 970                 975
Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly
            980                 985                 990
Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly
        995                 1000                1005
Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr
    1010                1015                1020
Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro
1025                1030                1035                1040
Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln
                1045                1050                1055
Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile
            1060                1065                1070
Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu
        1075                1080                1085
Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met
    1090                1095                1100
Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro
1105                1110                1115                1120
Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn
                1125                1130                1135
Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly
            1140                1145                1150
Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys
        1155                1160                1165
Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu
    1170                1175                1180
Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala
1185                1190                1195                1200
Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe
                1205                1210                1215
Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His
            1220                1225                1230
His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln Gln Gln Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Gln Gln Gln Gln Gln Gln Gln Gln Thr Gln Ala Phe Ser Pro Pro Pro
1265                1270                1275                1280
Asn Val Thr Ala Ser Pro Ser Met Asp Gly Leu Leu Ala Gly Pro Thr
                1285                1290                1295
Met Pro Gln Ala Pro Pro Gln Gln Phe Pro Tyr Gln Pro Asn Tyr Gly
            1300                1305                1310
Met Gly Gln Gln Pro Asp Pro Ala Phe Gly Arg Val Ser Ser Pro Pro
        1315                1320                1325
Asn Ala Met Met Ser Ser Arg Met Gly Pro Ser Gln Asn Pro Met Met
    1330                1335                1340
Gln His Pro Gln Ala Ala Ser Ile Tyr Gln Ser Ser Glu Met Lys Gly
1345                1350                1355                1360
Trp Pro Ser Gly Asn Leu Ala Arg Asn Ser Ser Phe Ser Gln Gln Gln
                1365                1370                1375
Phe Ala His Gln Gly Asn Pro Ala Val Tyr Ser Met Val His Met Asn
            1380                1385                1390
Gly Ser Ser Gly His Met Gly Gln Met Asn Met Asn Pro Met Pro Met
        1395                1400                1405
Ser Gly Met Pro Met Gly Pro Asp Gln Lys Tyr Cys
    1410                1415                1420

<210> 359
<211> 1417
<212> PRT
<213> Homo sapiens

<400> 359
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Glu Ala Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser
                325                 330                 335
Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe
            340                 345                 350
Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe
        355                 360                 365
Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly
    370                 375                 380
Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly
385                 390                 395                 400
Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala
                405                 410                 415
Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg
            420                 425                 430
Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met
        435                 440                 445
Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser
    450                 455                 460
Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile
465                 470                 475                 480
Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln
                485                 490                 495
Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn
            500                 505                 510
Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala
        515                 520                 525
Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro
    530                 535                 540
Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser
545                 550                 555                 560
Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp
                565                 570                 575
Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His
            580                 585                 590
Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn
        595                 600                 605
Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu
    610                 615                 620
Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser
625                 630                 635                 640
Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro
                645                 650                 655
Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn
            660                 665                 670
Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu
        675                 680                 685
Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu
    690                 695                 700
Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn
705                 710                 715                 720
Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala
                725                 730                 735
Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser
            740                 745                 750
Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln
        755                 760                 765
Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys
    770                 775                 780
Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu
785                 790                 795                 800
Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser
                805                 810                 815
Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln
            820                 825                 830
Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile
        835                 840                 845
Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val
    850                 855                 860
Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro
865                 870                 875                 880
Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu
                885                 890                 895
Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr
            900                 905                 910
Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly
        915                 920                 925
Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp
    930                 935                 940
Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr
945                 950                 955                 960
Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln
                965                 970                 975
Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly
            980                 985                 990
Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly
        995                 1000                1005
Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr
    1010                1015                1020
Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro
1025                1030                1035                1040
Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln
                1045                1050                1055
Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile
            1060                1065                1070
Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu
        1075                1080                1085
Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met
    1090                1095                1100
Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro
1105                1110                1115                1120
Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn
                1125                1130                1135
Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly
            1140                1145                1150
Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys
        1155                1160                1165
Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu
    1170                1175                1180
Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala
1185                1190                1195                1200
Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe
                1205                1210                1215
Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His
            1220                1225                1230
His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln Gln Gln Gln Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Gln Gln Gln Gln Gln Thr Gln Ala Phe Ser Pro Pro Pro Asn Val Thr
1265                1270                1275                1280
Ala Ser Pro Ser Met Asp Gly Leu Leu Ala Gly Pro Thr Met Pro Gln
                1285                1290                1295
Ala Pro Pro Gln Gln Phe Pro Tyr Gln Pro Asn Tyr Gly Met Gly Gln
            1300                1305                1310
Gln Pro Asp Pro Ala Phe Gly Arg Val Ser Ser Pro Pro Asn Ala Met
        1315                1320                1325
Met Ser Ser Arg Met Gly Pro Ser Gln Asn Pro Met Met Gln His Pro
    1330                1335                1340
Gln Ala Ala Ser Ile Tyr Gln Ser Ser Glu Met Lys Gly Trp Pro Ser
1345                1350                1355                1360
Gly Asn Leu Ala Arg Asn Ser Ser Phe Ser Gln Gln Gln Phe Ala His
                1365                1370                1375
Gln Gly Asn Pro Ala Val Tyr Ser Met Val His Met Asn Gly Ser Ser
            1380                1385                1390
Gly His Met Gly Gln Met Asn Met Asn Pro Met Pro Met Ser Gly Met
        1395                1400                1405
Pro Met Gly Pro Asp Gln Lys Tyr Cys
    1410                1415

<210> 360
<211> 1424
<212> PRT
<213> Homo sapiens

<400> 360
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320
Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser
                325                 330                 335
Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe
            340                 345                 350
Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe
        355                 360                 365
Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly
    370                 375                 380
Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly
385                 390                 395                 400
Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala
                405                 410                 415
Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg
            420                 425                 430
Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met
        435                 440                 445
Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser
    450                 455                 460
Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile
465                 470                 475                 480
Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln
                485                 490                 495
Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn
            500                 505                 510
Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala
        515                 520                 525
Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro
    530                 535                 540
Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser
545                 550                 555                 560
Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp
                565                 570                 575
Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His
            580                 585                 590
Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn
        595                 600                 605
Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu
    610                 615                 620
Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser
625                 630                 635                 640
Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro
                645                 650                 655
Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn
            660                 665                 670
Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu
        675                 680                 685
Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu
    690                 695                 700
Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn
705                 710                 715                 720
Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala
                725                 730                 735
Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser
            740                 745                 750
Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln
        755                 760                 765
Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys
    770                 775                 780
Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu
785                 790                 795                 800
Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser
                805                 810                 815
Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln
            820                 825                 830
Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile
        835                 840                 845
Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val
    850                 855                 860
Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro
865                 870                 875                 880
Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu
                885                 890                 895
Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr
            900                 905                 910
Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly
        915                 920                 925
Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp
    930                 935                 940
Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr
945                 950                 955                 960
Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln
                965                 970                 975
Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly
            980                 985                 990
Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly
        995                 1000                1005
Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr
    1010                1015                1020
Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro
1025                1030                1035                1040
Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln
                1045                1050                1055
Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile
            1060                1065                1070
Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu
        1075                1080                1085
Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met
    1090                1095                1100
Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro
1105                1110                1115                1120
Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn
                1125                1130                1135
Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly
            1140                1145                1150
Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys
        1155                1160                1165
Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu
    1170                1175                1180
Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala
1185                1190                1195                1200
Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Val Ser Ser
                1205                1210                1215
Gln Gln Gly Phe Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu
            1220                1225                1230
Leu Leu Ser His His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln
        1235                1240                1245
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Thr Gln Ala Phe
1265                1270                1275                1280
Ser Pro Pro Pro Asn Val Thr Ala Ser Pro Ser Met Asp Gly Leu Leu
                1285                1290                1295
Ala Gly Pro Thr Met Pro Gln Ala Pro Pro Gln Gln Phe Pro Tyr Gln
            1300                1305                1310
Pro Asn Tyr Gly Met Gly Gln Gln Pro Asp Pro Ala Phe Gly Arg Val
        1315                1320                1325
Ser Ser Pro Pro Asn Ala Met Met Ser Ser Arg Met Gly Pro Ser Gln
    1330                1335                1340
Asn Pro Met Met Gln His Pro Gln Ala Ala Ser Ile Tyr Gln Ser Ser
1345                1350                1355                1360
Glu Met Lys Gly Trp Pro Ser Gly Asn Leu Ala Arg Asn Ser Ser Phe
                1365                1370                1375
Ser Gln Gln Gln Phe Ala His Gln Gly Asn Pro Ala Val Tyr Ser Met
            1380                1385                1390
Val His Met Asn Gly Ser Ser Gly His Met Gly Gln Met Asn Met Asn
        1395                1400                1405
Pro Met Pro Met Ser Gly Met Pro Met Gly Pro Asp Gln Lys Tyr Cys
    1410                1415                1420

<210> 361
<211> 534
<212> PRT
<213> Homo sapiens

<400> 361
Met Asp Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu
 1               5                  10                  15
Gly Glu Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala
            20                  25                  30
Asp Thr Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn
        35                  40                  45
Tyr Ser Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe
    50                  55                  60
Leu Arg Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala
65                  70                  75                  80
Asn Leu Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met
                85                  90                  95
Phe Ser Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu
            100                 105                 110
Cys Met Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn
        115                 120                 125
Ile Val Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu
    130                 135                 140
His Pro Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe
145                 150                 155                 160
Gly Leu Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn
                165                 170                 175
Gln Lys Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly
            180                 185                 190
Ile Ala Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln
        195                 200                 205
Gln Asp Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro
    210                 215                 220
Leu Phe Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His
225                 230                 235                 240
Pro Phe Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro
                245                 250                 255
His Ala Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys
            260                 265                 270
Pro Ile Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu
        275                 280                 285
Leu Ala Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg
    290                 295                 300
Leu Thr Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His
305                 310                 315                 320
Gly Val Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met
                325                 330                 335
Pro Pro Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn
            340                 345                 350
Leu Gln Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser
        355                 360                 365
Lys Lys Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser
    370                 375                 380
Gly Tyr Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu
385                 390                 395                 400
Asp Thr Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala
                405                 410                 415
Leu Ile Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val
            420                 425                 430
Asp Lys Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile
        435                 440                 445
Phe Tyr Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe
    450                 455                 460
Glu Gly Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val
465                 470                 475                 480
Ser Ile Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr
                485                 490                 495
Tyr Arg Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr
            500                 505                 510
Leu Ala Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg
        515                 520                 525
Ser Pro Pro Trp Glu Pro
    530

<210> 362
<211> 501
<212> PRT
<213> Homo sapiens

<400> 362
Met Asp Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu
 1               5                  10                  15
Gly Glu Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala
            20                  25                  30
Asp Thr Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn
        35                  40                  45
Tyr Ser Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe
    50                  55                  60
Leu Arg Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala
65                  70                  75                  80
Asn Leu Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met
                85                  90                  95
Phe Ser Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu
            100                 105                 110
Cys Met Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn
        115                 120                 125
Ile Val Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu
    130                 135                 140
His Pro Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe
145                 150                 155                 160
Gly Leu Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn
                165                 170                 175
Gln Lys Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly
            180                 185                 190
Ile Ala Ala Gly Ser Thr Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln
        195                 200                 205
Gln Asp Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro
    210                 215                 220
Leu Phe Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His
225                 230                 235                 240
Pro Phe Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro
                245                 250                 255
His Ala Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys
            260                 265                 270
Pro Ile Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu
        275                 280                 285
Leu Ala Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg
    290                 295                 300
Leu Thr Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His
305                 310                 315                 320
Gly Val Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met
                325                 330                 335
Pro Pro Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn
            340                 345                 350
Leu Gln Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser
        355                 360                 365
Lys Lys Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser
    370                 375                 380
Gly Tyr Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu
385                 390                 395                 400
Asp Thr Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala
                405                 410                 415
Leu Ile Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val
            420                 425                 430
Asp Lys Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Val Ser
        435                 440                 445
Ile Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr
    450                 455                 460
Arg Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu
465                 470                 475                 480
Ala Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser
                485                 490                 495
Pro Pro Trp Glu Pro
            500

<210> 363
<211> 628
<212> PRT
<213> Homo sapiens

<400> 363
Met Ala Ala Ala Gly Ala Gly Pro Gly Gln Glu Ala Gly Ala Gly Pro
 1               5                  10                  15
Gly Pro Gly Ala Val Ala Asn Ala Thr Gly Ala Glu Glu Gly Glu Met
            20                  25                  30
Lys Pro Val Ala Ala Gly Ala Ala Ala Pro Pro Gly Glu Gly Ile Ser
        35                  40                  45
Ala Ala Pro Thr Val Glu Pro Ser Ser Gly Glu Ala Glu Gly Gly Glu
    50                  55                  60
Ala Asn Leu Val Asp Val Ser Gly Gly Leu Glu Thr Glu Ser Ser Asn
65                  70                  75                  80
Gly Lys Asp Thr Leu Glu Gly Ala Gly Asp Thr Ser Glu Val Met Asp
                85                  90                  95
Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu Gly Glu
            100                 105                 110
Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala Asp Thr
        115                 120                 125
Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn Tyr Ser
    130                 135                 140
Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe Leu Arg
145                 150                 155                 160
Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala Asn Leu
                165                 170                 175
Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met Phe Ser
            180                 185                 190
Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu Cys Met
        195                 200                 205
Thr Thr Arg His Arg Pro Gly Lys Thr Thr Trp Pro Asn Asn Ile Val
    210                 215                 220
Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu His Pro
225                 230                 235                 240
Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe Gly Leu
                245                 250                 255
Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn Gln Lys
            260                 265                 270
Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly Ile Ala
        275                 280                 285
Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln Gln Asp
    290                 295                 300
Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro Leu Phe
305                 310                 315                 320
Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His Pro Phe
                325                 330                 335
Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro Gln Ala
            340                 345                 350
Pro Asp Pro Glu Lys Leu Glu Ile Asp Cys Trp Ala Gly Lys Pro Ile
        355                 360                 365
Ser Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu Leu Ala
    370                 375                 380
Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg Leu Thr
385                 390                 395                 400
Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His Gly Val
                405                 410                 415
Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met Pro Pro
            420                 425                 430
Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn Leu Gln
        435                 440                 445
Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser Lys Lys
    450                 455                 460
Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser Gly Tyr
465                 470                 475                 480
Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu Asp Thr
                485                 490                 495
Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala Leu Ile
            500                 505                 510
Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val Asp Lys
        515                 520                 525
Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile Phe Tyr
    530                 535                 540
Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe Glu Gly
545                 550                 555                 560
Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val Ser Ile
                565                 570                 575
Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr Arg
            580                 585                 590
Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu Ala
        595                 600                 605
Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser Pro
    610                 615                 620
Pro Trp Glu Pro
625

<210> 364
<211> 628
<212> PRT
<213> Homo sapiens

<400> 364
Met Ala Ala Ala Gly Ala Gly Pro Gly Gln Glu Ala Gly Ala Gly Pro
 1               5                  10                  15
Gly Pro Gly Ala Val Ala Asn Ala Thr Gly Ala Glu Glu Gly Glu Met
            20                  25                  30
Lys Pro Val Ala Ala Gly Ala Ala Ala Pro Pro Gly Glu Gly Ile Ser
        35                  40                  45
Ala Ala Pro Thr Val Glu Pro Ser Ser Gly Glu Ala Glu Gly Gly Glu
    50                  55                  60
Ala Asn Leu Val Asp Val Ser Gly Gly Leu Glu Thr Glu Ser Ser Asn
65                  70                  75                  80
Gly Lys Asp Thr Leu Glu Gly Ala Gly Asp Thr Ser Glu Val Met Asp
                85                  90                  95
Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu Gly Glu
            100                 105                 110
Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala Asp Thr
        115                 120                 125
Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn Tyr Ser
    130                 135                 140
Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe Leu Arg
145                 150                 155                 160
Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala Asn Leu
                165                 170                 175
Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met Phe Ser
            180                 185                 190
Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu Cys Met
        195                 200                 205
Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn Ile Val
    210                 215                 220
Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu His Pro
225                 230                 235                 240
Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe Gly Leu
                245                 250                 255
Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn Gln Lys
            260                 265                 270
Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly Ile Ala
        275                 280                 285
Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln Gln Asp
    290                 295                 300
Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro Leu Phe
305                 310                 315                 320
Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His Pro Phe
                325                 330                 335
Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro His Ala
            340                 345                 350
Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys Pro Ile
        355                 360                 365
Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu Leu Ala
    370                 375                 380
Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg Leu Thr
385                 390                 395                 400
Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His Gly Val
                405                 410                 415
Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met Pro Pro
            420                 425                 430
Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn Leu Gln
        435                 440                 445
Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser Lys Lys
    450                 455                 460
Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser Gly Tyr
465                 470                 475                 480
Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu Asp Thr
                485                 490                 495
Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala Leu Ile
            500                 505                 510
Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val Asp Lys
        515                 520                 525
Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile Phe Tyr
    530                 535                 540
Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe Glu Gly
545                 550                 555                 560
Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val Ser Ile
                565                 570                 575
Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr Arg
            580                 585                 590
Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu Ala
        595                 600                 605
Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser Pro
    610                 615                 620
Pro Trp Glu Pro
625

<210> 365
<211> 628
<212> PRT
<213> Homo sapiens

<400> 365
Met Ala Ala Ala Gly Ala Gly Pro Gly Gln Glu Ala Gly Ala Gly Pro
 1               5                  10                  15
Gly Pro Gly Ala Val Ala Asn Ala Thr Gly Ala Glu Glu Gly Glu Met
            20                  25                  30
Lys Pro Val Ala Ala Gly Ala Ala Ala Pro Pro Gly Glu Gly Ile Ser
        35                  40                  45
Ala Ala Pro Thr Val Glu Pro Ser Ser Gly Glu Ala Glu Gly Gly Glu
    50                  55                  60
Ala Asn Leu Val Asp Val Ser Gly Gly Leu Glu Thr Glu Ser Ser Asn
65                  70                  75                  80
Gly Lys Asp Thr Leu Glu Gly Ala Gly Asp Thr Ser Glu Val Met Asp
                85                  90                  95
Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu Gly Glu
            100                 105                 110
Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala Asp Thr
        115                 120                 125
Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn Tyr Ser
    130                 135                 140
Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe Leu Arg
145                 150                 155                 160
Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala Asn Leu
                165                 170                 175
Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met Phe Ser
            180                 185                 190
Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu Cys Met
        195                 200                 205
Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn Ile Val
    210                 215                 220
Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu His Pro
225                 230                 235                 240
Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe Gly Leu
                245                 250                 255
Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn Gln Lys
            260                 265                 270
Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly Ile Ala
        275                 280                 285
Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln Gln Asp
    290                 295                 300
Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro Leu Phe
305                 310                 315                 320
Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His Pro Phe
                325                 330                 335
Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro His Ala
            340                 345                 350
Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys Pro Ile
        355                 360                 365
Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu Leu Ala
    370                 375                 380
Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg Leu Thr
385                 390                 395                 400
Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His Gly Val
                405                 410                 415
Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met Pro Pro
            420                 425                 430
Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn Leu Gln
        435                 440                 445
Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser Lys Lys
    450                 455                 460
Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser Gly Tyr
465                 470                 475                 480
Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu Asp Thr
                485                 490                 495
Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala Leu Ile
            500                 505                 510
Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val Asp Lys
        515                 520                 525
Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile Phe Tyr
    530                 535                 540
Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe Glu Gly
545                 550                 555                 560
Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val Ser Ile
                565                 570                 575
Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr Arg
            580                 585                 590
Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu Ala
        595                 600                 605
Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser Pro
    610                 615                 620
Pro Trp Glu Pro
625

<210> 366
<211> 628
<212> PRT
<213> Homo sapiens

<400> 366
Met Ala Ala Ala Gly Ala Gly Pro Gly Gln Glu Ala Gly Ala Gly Pro
 1               5                  10                  15
Gly Pro Gly Ala Val Ala Asn Ala Thr Gly Ala Glu Glu Gly Glu Met
            20                  25                  30
Lys Pro Val Ala Ala Gly Ala Ala Ala Pro Pro Gly Glu Gly Ile Ser
        35                  40                  45
Ala Ala Pro Thr Val Glu Pro Ser Ser Gly Glu Ala Glu Gly Gly Glu
    50                  55                  60
Ala Asn Leu Val Asp Val Ser Gly Gly Leu Glu Thr Glu Ser Ser Asn
65                  70                  75                  80
Gly Lys Asp Thr Leu Glu Gly Ala Gly Asp Thr Ser Glu Val Met Asp
                85                  90                  95
Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu Gly Glu
            100                 105                 110
Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala Asp Thr
        115                 120                 125
Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn Tyr Ser
    130                 135                 140
Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe Leu Arg
145                 150                 155                 160
Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala Asn Leu
                165                 170                 175
Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met Phe Ser
            180                 185                 190
Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu Cys Met
        195                 200                 205
Thr Thr Arg His Arg Pro Gly Lys Thr Thr Trp Pro Asn Asn Ile Val
    210                 215                 220
Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu His Pro
225                 230                 235                 240
Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe Gly Leu
                245                 250                 255
Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn Gln Lys
            260                 265                 270
Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly Ile Ala
        275                 280                 285
Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln Gln Asp
    290                 295                 300
Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro Leu Phe
305                 310                 315                 320
Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His Pro Phe
                325                 330                 335
Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro Gln Ala
            340                 345                 350
Pro Asp Pro Glu Lys Leu Glu Ile Asp Cys Trp Ala Gly Lys Pro Ile
        355                 360                 365
Ser Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu Leu Ala
    370                 375                 380
Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg Leu Thr
385                 390                 395                 400
Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His Gly Val
                405                 410                 415
Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met Pro Pro
            420                 425                 430
Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn Leu Gln
        435                 440                 445
Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser Lys Lys
    450                 455                 460
Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser Gly Tyr
465                 470                 475                 480
Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu Asp Thr
                485                 490                 495
Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala Leu Ile
            500                 505                 510
Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val Asp Lys
        515                 520                 525
Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile Phe Tyr
    530                 535                 540
Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe Glu Gly
545                 550                 555                 560
Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val Ser Ile
                565                 570                 575
Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr Arg
            580                 585                 590
Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu Ala
        595                 600                 605
Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser Pro
    610                 615                 620
Pro Trp Glu Pro
625

<210> 367
<211> 501
<212> PRT
<213> Homo sapiens

<400> 367
Met Asp Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu
 1               5                  10                  15
Gly Glu Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala
            20                  25                  30
Asp Thr Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn
        35                  40                  45
Tyr Ser Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe
    50                  55                  60
Leu Arg Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala
65                  70                  75                  80
Asn Leu Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met
                85                  90                  95
Phe Ser Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu
            100                 105                 110
Cys Met Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn
        115                 120                 125
Ile Val Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu
    130                 135                 140
His Pro Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe
145                 150                 155                 160
Gly Leu Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn
                165                 170                 175
Gln Lys Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly
            180                 185                 190
Ile Ala Ala Gly Ser Thr Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln
        195                 200                 205
Gln Asp Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro
    210                 215                 220
Leu Phe Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His
225                 230                 235                 240
Pro Phe Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro
                245                 250                 255
His Ala Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys
            260                 265                 270
Pro Ile Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu
        275                 280                 285
Leu Ala Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg
    290                 295                 300
Leu Thr Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His
305                 310                 315                 320
Gly Val Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met
                325                 330                 335
Pro Pro Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn
            340                 345                 350
Leu Gln Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser
        355                 360                 365
Lys Lys Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser
    370                 375                 380
Gly Tyr Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu
385                 390                 395                 400
Asp Thr Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala
                405                 410                 415
Leu Ile Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val
            420                 425                 430
Asp Lys Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Val Ser
        435                 440                 445
Ile Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr
    450                 455                 460
Arg Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu
465                 470                 475                 480
Ala Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser
                485                 490                 495
Pro Pro Trp Glu Pro
            500

<210> 368
<211> 628
<212> PRT
<213> Homo sapiens

<400> 368
Met Ala Ala Ala Gly Ala Gly Pro Gly Gln Glu Ala Gly Ala Gly Pro
 1               5                  10                  15
Gly Pro Gly Ala Val Ala Asn Ala Thr Gly Ala Glu Glu Gly Glu Met
            20                  25                  30
Lys Pro Val Ala Ala Gly Ala Ala Ala Pro Pro Gly Glu Gly Ile Ser
        35                  40                  45
Ala Ala Pro Thr Val Glu Pro Ser Ser Gly Glu Ala Glu Gly Gly Glu
    50                  55                  60
Ala Asn Leu Val Asp Val Ser Gly Gly Leu Glu Thr Glu Ser Ser Asn
65                  70                  75                  80
Gly Lys Asp Thr Leu Glu Gly Ala Gly Asp Thr Ser Glu Val Met Asp
                85                  90                  95
Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu Gly Glu
            100                 105                 110
Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala Asp Thr
        115                 120                 125
Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn Tyr Ser
    130                 135                 140
Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe Leu Arg
145                 150                 155                 160
Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala Asn Leu
                165                 170                 175
Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met Phe Ser
            180                 185                 190
Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu Cys Met
        195                 200                 205
Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn Ile Val
    210                 215                 220
Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu His Pro
225                 230                 235                 240
Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe Gly Leu
                245                 250                 255
Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn Gln Lys
            260                 265                 270
Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly Ile Ala
        275                 280                 285
Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln Gln Asp
    290                 295                 300
Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro Leu Phe
305                 310                 315                 320
Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His Pro Phe
                325                 330                 335
Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro His Ala
            340                 345                 350
Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys Pro Ile
        355                 360                 365
Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu Leu Ala
    370                 375                 380
Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg Leu Thr
385                 390                 395                 400
Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His Gly Val
                405                 410                 415
Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met Pro Pro
            420                 425                 430
Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn Leu Gln
        435                 440                 445
Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser Lys Lys
    450                 455                 460
Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser Gly Tyr
465                 470                 475                 480
Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu Asp Thr
                485                 490                 495
Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala Leu Ile
            500                 505                 510
Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val Asp Lys
        515                 520                 525
Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile Phe Tyr
    530                 535                 540
Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe Glu Gly
545                 550                 555                 560
Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val Ser Ile
                565                 570                 575
Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr Arg
            580                 585                 590
Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu Ala
        595                 600                 605
Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser Pro
    610                 615                 620
Pro Trp Glu Pro
625

<210> 369
<211> 628
<212> PRT
<213> Homo sapiens

<400> 369
Met Ala Ala Ala Gly Ala Gly Pro Gly Gln Glu Ala Gly Ala Gly Pro
 1               5                  10                  15
Gly Pro Gly Ala Val Ala Asn Ala Thr Gly Ala Glu Glu Gly Glu Met
            20                  25                  30
Lys Pro Val Ala Ala Gly Ala Ala Ala Pro Pro Gly Glu Gly Ile Ser
        35                  40                  45
Ala Ala Pro Thr Val Glu Pro Ser Ser Gly Glu Ala Glu Gly Gly Glu
    50                  55                  60
Ala Asn Leu Val Asp Val Ser Gly Gly Leu Glu Thr Glu Ser Ser Asn
65                  70                  75                  80
Gly Lys Asp Thr Leu Glu Gly Ala Gly Asp Thr Ser Glu Val Met Asp
                85                  90                  95
Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu Gly Glu
            100                 105                 110
Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala Asp Thr
        115                 120                 125
Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn Tyr Ser
    130                 135                 140
Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe Leu Arg
145                 150                 155                 160
Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala Asn Leu
                165                 170                 175
Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met Phe Ser
            180                 185                 190
Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu Cys Met
        195                 200                 205
Thr Thr Arg His Arg Pro Gly Lys Thr Thr Trp Pro Asn Asn Ile Val
    210                 215                 220
Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu His Pro
225                 230                 235                 240
Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe Gly Leu
                245                 250                 255
Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn Gln Lys
            260                 265                 270
Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly Ile Ala
        275                 280                 285
Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln Gln Asp
    290                 295                 300
Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro Leu Phe
305                 310                 315                 320
Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His Pro Phe
                325                 330                 335
Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro Gln Ala
            340                 345                 350
Pro Asp Pro Glu Lys Leu Glu Ile Asp Cys Trp Ala Gly Lys Pro Ile
        355                 360                 365
Ser Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu Leu Ala
    370                 375                 380
Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg Leu Thr
385                 390                 395                 400
Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His Gly Val
                405                 410                 415
Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met Pro Pro
            420                 425                 430
Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn Leu Gln
        435                 440                 445
Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser Lys Lys
    450                 455                 460
Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser Gly Tyr
465                 470                 475                 480
Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu Asp Thr
                485                 490                 495
Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala Leu Ile
            500                 505                 510
Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val Asp Lys
        515                 520                 525
Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile Phe Tyr
    530                 535                 540
Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe Glu Gly
545                 550                 555                 560
Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val Ser Ile
                565                 570                 575
Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr Arg
            580                 585                 590
Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu Ala
        595                 600                 605
Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser Pro
    610                 615                 620
Pro Trp Glu Pro
625

<210> 370
<211> 501
<212> PRT
<213> Homo sapiens

<400> 370
Met Asp Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu
 1               5                  10                  15
Gly Glu Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala
            20                  25                  30
Asp Thr Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn
        35                  40                  45
Tyr Ser Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe
    50                  55                  60
Leu Arg Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala
65                  70                  75                  80
Asn Leu Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met
                85                  90                  95
Phe Ser Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu
            100                 105                 110
Cys Met Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn
        115                 120                 125
Ile Val Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu
    130                 135                 140
His Pro Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe
145                 150                 155                 160
Gly Leu Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn
                165                 170                 175
Gln Lys Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly
            180                 185                 190
Ile Ala Ala Gly Ser Thr Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln
        195                 200                 205
Gln Asp Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro
    210                 215                 220
Leu Phe Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His
225                 230                 235                 240
Pro Phe Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro
                245                 250                 255
His Ala Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys
            260                 265                 270
Pro Ile Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu
        275                 280                 285
Leu Ala Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg
    290                 295                 300
Leu Thr Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His
305                 310                 315                 320
Gly Val Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met
                325                 330                 335
Pro Pro Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn
            340                 345                 350
Leu Gln Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser
        355                 360                 365
Lys Lys Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser
    370                 375                 380
Gly Tyr Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu
385                 390                 395                 400
Asp Thr Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala
                405                 410                 415
Leu Ile Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val
            420                 425                 430
Asp Lys Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Val Ser
        435                 440                 445
Ile Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr
    450                 455                 460
Arg Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu
465                 470                 475                 480
Ala Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser
                485                 490                 495
Pro Pro Trp Glu Pro
            500

<210> 371
<211> 628
<212> PRT
<213> Homo sapiens

<400> 371
Met Ala Ala Ala Gly Ala Gly Pro Gly Gln Glu Ala Gly Ala Gly Pro
 1               5                  10                  15
Gly Pro Gly Ala Val Ala Asn Ala Thr Gly Ala Glu Glu Gly Glu Met
            20                  25                  30
Lys Pro Val Ala Ala Gly Ala Ala Ala Pro Pro Gly Glu Gly Ile Ser
        35                  40                  45
Ala Ala Pro Thr Val Glu Pro Ser Ser Gly Glu Ala Glu Gly Gly Glu
    50                  55                  60
Ala Asn Leu Val Asp Val Ser Gly Gly Leu Glu Thr Glu Ser Ser Asn
65                  70                  75                  80
Gly Lys Asp Thr Leu Glu Gly Ala Gly Asp Thr Ser Glu Val Met Asp
                85                  90                  95
Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu Gly Glu
            100                 105                 110
Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala Asp Thr
        115                 120                 125
Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn Tyr Ser
    130                 135                 140
Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe Leu Arg
145                 150                 155                 160
Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala Asn Leu
                165                 170                 175
Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met Phe Ser
            180                 185                 190
Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu Cys Met
        195                 200                 205
Thr Thr Arg His Arg Pro Gly Lys Thr Thr Trp Pro Asn Asn Ile Val
    210                 215                 220
Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu His Pro
225                 230                 235                 240
Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe Gly Leu
                245                 250                 255
Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn Gln Lys
            260                 265                 270
Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly Ile Ala
        275                 280                 285
Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln Gln Asp
    290                 295                 300
Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro Leu Phe
305                 310                 315                 320
Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His Pro Phe
                325                 330                 335
Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro Gln Ala
            340                 345                 350
Pro Asp Pro Glu Lys Leu Glu Ile Asp Cys Trp Ala Gly Lys Pro Ile
        355                 360                 365
Ser Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu Leu Ala
    370                 375                 380
Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg Leu Thr
385                 390                 395                 400
Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His Gly Val
                405                 410                 415
Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met Pro Pro
            420                 425                 430
Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn Leu Gln
        435                 440                 445
Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser Lys Lys
    450                 455                 460
Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser Gly Tyr
465                 470                 475                 480
Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu Asp Thr
                485                 490                 495
Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala Leu Ile
            500                 505                 510
Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val Asp Lys
        515                 520                 525
Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile Phe Tyr
    530                 535                 540
Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe Glu Gly
545                 550                 555                 560
Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val Ser Ile
                565                 570                 575
Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr Arg
            580                 585                 590
Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu Ala
        595                 600                 605
Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser Pro
    610                 615                 620
Pro Trp Glu Pro
625

<210> 372
<211> 534
<212> PRT
<213> Homo sapiens

<400> 372
Met Asp Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu
 1               5                  10                  15
Gly Glu Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala
            20                  25                  30
Asp Thr Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn
        35                  40                  45
Tyr Ser Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe
    50                  55                  60
Leu Arg Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala
65                  70                  75                  80
Asn Leu Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met
                85                  90                  95
Phe Ser Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu
            100                 105                 110
Cys Met Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn
        115                 120                 125
Ile Val Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu
    130                 135                 140
His Pro Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe
145                 150                 155                 160
Gly Leu Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn
                165                 170                 175
Gln Lys Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly
            180                 185                 190
Ile Ala Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln
        195                 200                 205
Gln Asp Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro
    210                 215                 220
Leu Phe Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His
225                 230                 235                 240
Pro Phe Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro
                245                 250                 255
His Ala Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys
            260                 265                 270
Pro Ile Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu
        275                 280                 285
Leu Ala Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg
    290                 295                 300
Leu Thr Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His
305                 310                 315                 320
Gly Val Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met
                325                 330                 335
Pro Pro Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn
            340                 345                 350
Leu Gln Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser
        355                 360                 365
Lys Lys Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser
    370                 375                 380
Gly Tyr Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu
385                 390                 395                 400
Asp Thr Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala
                405                 410                 415
Leu Ile Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val
            420                 425                 430
Asp Lys Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile
        435                 440                 445
Phe Tyr Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe
    450                 455                 460
Glu Gly Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val
465                 470                 475                 480
Ser Ile Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr
                485                 490                 495
Tyr Arg Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr
            500                 505                 510
Leu Ala Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg
        515                 520                 525
Ser Pro Pro Trp Glu Pro
    530

<210> 373
<211> 628
<212> PRT
<213> Homo sapiens

<400> 373
Met Ala Ala Ala Gly Ala Gly Pro Gly Gln Glu Ala Gly Ala Gly Pro
 1               5                  10                  15
Gly Pro Gly Ala Val Ala Asn Ala Thr Gly Ala Glu Glu Gly Glu Met
            20                  25                  30
Lys Pro Val Ala Ala Gly Ala Ala Ala Pro Pro Gly Glu Gly Ile Ser
        35                  40                  45
Ala Ala Pro Thr Val Glu Pro Ser Ser Gly Glu Ala Glu Gly Gly Glu
    50                  55                  60
Ala Asn Leu Val Asp Val Ser Gly Gly Leu Glu Thr Glu Ser Ser Asn
65                  70                  75                  80
Gly Lys Asp Thr Leu Glu Gly Ala Gly Asp Thr Ser Glu Val Met Asp
                85                  90                  95
Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu Gly Glu
            100                 105                 110
Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala Asp Thr
        115                 120                 125
Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn Tyr Ser
    130                 135                 140
Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe Leu Arg
145                 150                 155                 160
Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala Asn Leu
                165                 170                 175
Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met Phe Ser
            180                 185                 190
Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu Cys Met
        195                 200                 205
Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn Ile Val
    210                 215                 220
Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu His Pro
225                 230                 235                 240
Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe Gly Leu
                245                 250                 255
Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn Gln Lys
            260                 265                 270
Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly Ile Ala
        275                 280                 285
Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln Gln Asp
    290                 295                 300
Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro Leu Phe
305                 310                 315                 320
Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His Pro Phe
                325                 330                 335
Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro His Ala
            340                 345                 350
Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys Pro Ile
        355                 360                 365
Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu Leu Ala
    370                 375                 380
Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg Leu Thr
385                 390                 395                 400
Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His Gly Val
                405                 410                 415
Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met Pro Pro
            420                 425                 430
Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn Leu Gln
        435                 440                 445
Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser Lys Lys
    450                 455                 460
Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser Gly Tyr
465                 470                 475                 480
Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu Asp Thr
                485                 490                 495
Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala Leu Ile
            500                 505                 510
Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val Asp Lys
        515                 520                 525
Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile Phe Tyr
    530                 535                 540
Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe Glu Gly
545                 550                 555                 560
Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val Ser Ile
                565                 570                 575
Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr Arg
            580                 585                 590
Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu Ala
        595                 600                 605
Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser Pro
    610                 615                 620
Pro Trp Glu Pro
625

<210> 374
<211> 219
<212> PRT
<213> Homo sapiens

<400> 374
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 375
<211> 219
<212> PRT
<213> Homo sapiens

<400> 375
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 376
<211> 231
<212> PRT
<213> Homo sapiens

<400> 376
Gly Thr Val Pro Gly Lys Gly Gln Glu Tyr His Gly Met Gly Met Ser
 1               5                  10                  15
Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe Asn Leu Leu Phe
            20                  25                  30
Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile Tyr Leu Leu Ile
        35                  40                  45
His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro Ser Leu Thr Leu
    50                  55                  60
Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met Val Val Ala Phe
65                  70                  75                  80
Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys Leu Leu Met Ser
                85                  90                  95
Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu Val Thr Leu Ala
            100                 105                 110
Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala Lys
        115                 120                 125
Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr Lys
    130                 135                 140
Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile Asn
145                 150                 155                 160
Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser Asp
                165                 170                 175
Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His Ser
            180                 185                 190
Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile Glu
        195                 200                 205
Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile Asp Lys
    210                 215                 220
Thr Ser Gln Thr Ile Gly Leu
225                 230

<210> 377
<211> 219
<212> PRT
<213> Homo sapiens

<400> 377
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 378
<211> 219
<212> PRT
<213> Homo sapiens

<400> 378
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 379
<211> 219
<212> PRT
<213> Homo sapiens

<400> 379
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ser Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Thr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 380
<211> 219
<212> PRT
<213> Homo sapiens

<400> 380
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 381
<211> 219
<212> PRT
<213> Homo sapiens

<400> 381
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 382
<211> 219
<212> PRT
<213> Homo sapiens

<400> 382
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 383
<211> 219
<212> PRT
<213> Homo sapiens

<400> 383
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 384
<211> 219
<212> PRT
<213> Homo sapiens

<400> 384
Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe
 1               5                  10                  15
Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile
            20                  25                  30
Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro
        35                  40                  45
Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met
    50                  55                  60
Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys
65                  70                  75                  80
Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu
                85                  90                  95
Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu
            100                 105                 110
Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp
        115                 120                 125
Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys
    130                 135                 140
Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser
145                 150                 155                 160
Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu
                165                 170                 175
Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val
            180                 185                 190
Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys
        195                 200                 205
Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu
    210                 215

<210> 385
<211> 566
<212> PRT
<213> Homo sapiens

<400> 385
Met Pro Gly Lys Pro Lys His Leu Gly Val Pro Asn Gly Arg Met Val
 1               5                  10                  15
Leu Ala Val Ser Asp Gly Glu Leu Ser Ser Thr Thr Gly Pro Gln Gly
            20                  25                  30
Gln Gly Glu Gly Arg Gly Ser Ser Leu Ser Ile His Ser Leu Pro Ser
        35                  40                  45
Gly Pro Ser Ser Pro Phe Pro Thr Glu Glu Gln Pro Val Ala Ser Trp
    50                  55                  60
Ala Leu Ser Phe Glu Arg Leu Leu Gln Asp Pro Leu Gly Leu Ala Tyr
65                  70                  75                  80
Phe Thr Glu Phe Leu Lys Lys Glu Phe Ser Ala Glu Asn Val Thr Phe
                85                  90                  95
Trp Lys Ala Cys Glu Arg Phe Gln Gln Ile Pro Ala Ser Asp Thr Gln
            100                 105                 110
Gln Leu Ala Gln Glu Ala Arg Asn Ile Tyr Gln Glu Phe Leu Ser Ser
        115                 120                 125
Gln Ala Leu Ser Pro Val Asn Ile Asp Arg Gln Ala Trp Leu Gly Glu
    130                 135                 140
Glu Val Leu Ala Glu Pro Arg Pro Asp Met Phe Arg Ala Gln Gln Leu
145                 150                 155                 160
Gln Ile Phe Asn Leu Met Lys Phe Asp Ser Tyr Ala Arg Phe Val Lys
                165                 170                 175
Ser Pro Leu Tyr Arg Glu Cys Leu Leu Ala Glu Ala Glu Gly Arg Pro
            180                 185                 190
Leu Arg Glu Pro Gly Ser Ser Arg Leu Gly Ser Pro Asp Ala Thr Arg
        195                 200                 205
Lys Lys Pro Lys Leu Lys Pro Gly Lys Ser Leu Pro Leu Gly Val Glu
    210                 215                 220
Glu Leu Gly Gln Leu Pro Pro Val Glu Gly Pro Gly Gly Arg Pro Leu
225                 230                 235                 240
Arg Lys Ser Phe Arg Arg Glu Leu Gly Gly Thr Ala Asn Ala Ala Leu
                245                 250                 255
Arg Arg Glu Ser Gln Gly Ser Leu Asn Ser Ser Ala Ser Leu Asp Leu
            260                 265                 270
Gly Phe Leu Ala Phe Val Ser Ser Lys Ser Glu Ser His Arg Lys Ser
        275                 280                 285
Leu Gly Ser Thr Glu Gly Glu Ser Glu Ser Arg Pro Gly Lys Tyr Cys
    290                 295                 300
Cys Val Tyr Leu Pro Asp Gly Thr Ala Ser Leu Ala Leu Ala Arg Pro
305                 310                 315                 320
Gly Leu Thr Ile Arg Asp Met Leu Ala Gly Ile Cys Glu Lys Arg Gly
                325                 330                 335
Leu Ser Leu Pro Asp Ile Lys Val Tyr Leu Val Gly Asn Glu Gln Ala
            340                 345                 350
Leu Val Leu Asp Gln Asp Cys Thr Val Leu Ala Asp Gln Glu Val Arg
        355                 360                 365
Leu Glu Asn Arg Ile Thr Phe Glu Leu Glu Leu Thr Ala Leu Glu Arg
    370                 375                 380
Val Val Arg Ile Ser Ala Lys Pro Thr Lys Arg Leu Gln Glu Ala Leu
385                 390                 395                 400
Gln Pro Ile Leu Glu Lys His Gly Leu Ser Pro Leu Glu Val Val Leu
                405                 410                 415
His Arg Pro Gly Glu Lys Gln Pro Leu Asp Leu Gly Lys Leu Val Ser
            420                 425                 430
Ser Val Ala Ala Gln Arg Leu Val Leu Asp Thr Leu Pro Gly Val Lys
        435                 440                 445
Ile Ser Lys Ala Arg Asp Lys Ser Pro Cys Arg Ser Gln Gly Cys Pro
    450                 455                 460
Pro Arg Thr Gln Asp Lys Ala Thr His Pro Pro Pro Ala Ser Pro Ser
465                 470                 475                 480
Ser Leu Val Lys Val Pro Ser Ser Ala Thr Gly Lys Arg Gln Thr Cys
                485                 490                 495
Asp Ile Glu Gly Leu Val Glu Leu Leu Asn Arg Val Gln Ser Ser Gly
            500                 505                 510
Ala His Asp Gln Arg Gly Leu Leu Arg Lys Glu Asp Leu Val Leu Pro
        515                 520                 525
Glu Phe Leu Gln Leu Pro Ala Gln Gly Pro Ser Ser Glu Glu Thr Pro
    530                 535                 540
Pro Gln Thr Lys Ser Ala Ala Gln Pro Ile Gly Gly Ser Leu Asn Ser
545                 550                 555                 560
Thr Thr Asp Ser Ala Leu
                565

<210> 386
<211> 441
<212> PRT
<213> Homo sapiens

<400> 386
Met Phe Arg Ala Gln Gln Leu Gln Ile Phe Asn Leu Met Lys Phe Asp
 1               5                  10                  15
Ser Tyr Ala Arg Phe Val Lys Ser Pro Leu Tyr Arg Glu Cys Leu Leu
            20                  25                  30
Ala Glu Ala Glu Gly Arg Pro Leu Arg Glu Pro Gly Ser Ser Arg Leu
        35                  40                  45
Gly Ser Pro Asp Ala Thr Arg Lys Lys Pro Lys Leu Lys Pro Gly Lys
    50                  55                  60
Ser Leu Pro Leu Gly Val Glu Glu Leu Gly Gln Leu Pro Pro Val Glu
65                  70                  75                  80
Gly Pro Gly Gly Arg Pro Leu Arg Lys Ser Phe Arg Arg Glu Leu Gly
                85                  90                  95
Gly Thr Ala Asn Ala Ala Leu Arg Arg Glu Ser Gln Gly Ser Leu Asn
            100                 105                 110
Ser Ser Ala Ser Leu Asp Leu Gly Phe Leu Ala Phe Val Ser Ser Lys
        115                 120                 125
Ser Glu Ser His Arg Lys Ser Leu Gly Ser Thr Glu Gly Glu Ser Glu
    130                 135                 140
Ser Arg Pro Gly Lys Tyr Cys Cys Val Tyr Leu Pro Asp Gly Thr Ala
145                 150                 155                 160
Ser Leu Ala Leu Ala Arg Pro Gly Leu Thr Ile Arg Asp Met Leu Ala
                165                 170                 175
Gly Ile Cys Glu Lys Arg Gly Ser Leu Tyr Leu Thr Ser Ser Leu Pro
            180                 185                 190
Gly Gly Asn Glu Gln Lys Ala Leu Val Leu Asp Gln Asp Cys Thr Val
        195                 200                 205
Leu Ala Asp Gln Glu Val Arg Leu Glu Asn Arg Ile Thr Phe Glu Leu
    210                 215                 220
Glu Leu Thr Ala Leu Glu Arg Val Val Arg Ile Ser Ala Lys Pro Thr
225                 230                 235                 240
Lys Arg Leu Gln Glu Ala Leu Gln Pro Ile Leu Glu Lys His Gly Leu
                245                 250                 255
Ser Pro Leu Glu Val Val Leu His Arg Pro Gly Glu Lys Gln Pro Leu
            260                 265                 270
Asp Leu Gly Lys Leu Val Ser Ser Val Ala Ala Gln Arg Leu Val Leu
        275                 280                 285
Asp Thr Leu Pro Gly Val Lys Ile Ser Lys Ala Arg Asp Lys Ser Pro
    290                 295                 300
Cys Arg Ser Gln Gly Cys Pro Pro Arg Thr Gln Asp Lys Ala Thr His
305                 310                 315                 320
Pro Pro Pro Ala Ser Pro Ser Ser Leu Val Lys Val Pro Ser Ser Ala
                325                 330                 335
Thr Gly Lys Arg Gln Thr Cys Asp Ile Glu Gly Leu Glu Leu Leu Asn
            340                 345                 350
Arg Val Gln Ser Ser Gly Ala His Asp Gln Arg Gly Leu Leu Arg Lys
        355                 360                 365
Glu Asp Leu Val Leu Pro Glu Phe Leu Gln Leu Pro Ala Gln Gly Pro
    370                 375                 380
Ala Pro Arg Arg Pro Thr Thr Asp Gln Ile Ser Ser Pro Ala His Arg
385                 390                 395                 400
Gly Ile Leu Glu Leu His His Arg Leu Ser Pro Leu Thr Ala Thr Gln
                405                 410                 415
Gln Ser Arg Thr Ala Ala Trp His Pro Ala Gly Arg Ala Cys His Gly
            420                 425                 430
Ser Ala Leu His Ala Leu Ser Val Pro
        435                 440

<210> 387
<211> 487
<212> PRT
<213> Homo sapiens

<400> 387
Met Pro Gly Lys Pro Lys His Leu Gly Val Pro Asn Gly Arg Met Val
 1               5                  10                  15
Leu Ala Val Ser Asp Gly Glu Leu Ser Ser Thr Thr Gly Pro Gln Gly
            20                  25                  30
Gln Gly Glu Gly Arg Gly Ser Ser Leu Ser Ile His Ser Leu Pro Ser
        35                  40                  45
Gly Pro Ser Ser Pro Phe Pro Thr Glu Glu Gln Pro Val Ala Ser Trp
    50                  55                  60
Ala Leu Ser Phe Glu Arg Leu Leu Gln Asp Pro Leu Gly Leu Ala Tyr
65                  70                  75                  80
Phe Thr Glu Phe Leu Lys Lys Glu Phe Ser Ala Glu Asn Val Thr Phe
                85                  90                  95
Trp Lys Ala Cys Glu Arg Phe Gln Gln Ile Pro Ala Ser Asp Thr Gln
            100                 105                 110
Gln Leu Ala Gln Glu Ala Arg Asn Ile Tyr Gln Glu Phe Leu Ser Ser
        115                 120                 125
Gln Ala Leu Ser Pro Val Asn Ile Asp Arg Gln Ala Trp Leu Gly Glu
    130                 135                 140
Glu Val Leu Ala Glu Pro Arg Pro Asp Met Phe Arg Ala Gln Gln Leu
145                 150                 155                 160
Gln Ile Phe Asn Leu Met Lys Phe Asp Ser Tyr Ala Arg Phe Val Lys
                165                 170                 175
Ser Pro Leu Tyr Arg Glu Cys Leu Leu Ala Glu Ala Glu Gly Arg Pro
            180                 185                 190
Leu Arg Glu Pro Gly Ser Ser Arg Leu Gly Ser Pro Asp Ala Thr Arg
        195                 200                 205
Lys Lys Pro Lys Leu Lys Pro Gly Lys Ser Leu Pro Leu Gly Val Glu
    210                 215                 220
Glu Leu Gly Gln Leu Pro Pro Val Glu Gly Pro Gly Gly Arg Pro Leu
225                 230                 235                 240
Arg Lys Ser Phe Arg Arg Glu Leu Gly Gly Thr Ala Asn Ala Ala Leu
                245                 250                 255
Arg Arg Glu Ser Gln Gly Ser Leu Asn Ser Ser Ala Ser Leu Asp Leu
            260                 265                 270
Gly Phe Leu Ala Phe Val Ser Ser Lys Ser Glu Ser His Arg Lys Ser
        275                 280                 285
Leu Gly Ser Thr Glu Gly Glu Ser Glu Ser Arg Pro Gly Lys Tyr Cys
    290                 295                 300
Cys Val Tyr Leu Pro Asp Gly Thr Ala Ser Leu Ala Leu Ala Arg Pro
305                 310                 315                 320
Gly Leu Thr Ile Arg Asp Met Leu Ala Gly Ile Cys Glu Lys Arg Gly
                325                 330                 335
Leu Ser Leu Pro Asp Ile Lys Val Tyr Leu Val Gly Asn Glu Gln Lys
            340                 345                 350
Ala Leu Val Leu Asp Gln Asp Cys Thr Val Leu Ala Asp Gln Glu Val
        355                 360                 365
Arg Leu Glu Asn Arg Ile Thr Phe Glu Leu Glu Leu Thr Ala Leu Glu
    370                 375                 380
Arg Val Val Arg Ile Ser Ala Lys Pro Thr Lys Arg Leu Gln Glu Ala
385                 390                 395                 400
Leu Gln Pro Ile Leu Glu Lys His Gly Leu Ser Pro Leu Glu Val Val
                405                 410                 415
Leu His Arg Pro Gly Glu Lys Gln Pro Leu Asp Leu Gly Lys Leu Val
            420                 425                 430
Ser Ser Val Ala Ala Gln Arg Leu Val Leu Asp Thr Leu Pro Gly Val
        435                 440                 445
Lys Ile Ser Lys Ala Arg Asp Lys Ser Pro Cys Arg Ser Gln Val Ser
    450                 455                 460
Glu Arg Ala Ala His Leu Glu Leu Arg Ile Arg Pro Pro Ile Pro Leu
465                 470                 475                 480
Gln Arg Pro Pro Val Leu Trp
                485

<210> 388
<211> 441
<212> PRT
<213> Homo sapiens

<400> 388
Met Phe Arg Ala Gln Gln Leu Gln Ile Phe Asn Leu Met Lys Phe Asp
 1               5                  10                  15
Ser Tyr Ala Arg Phe Val Lys Ser Pro Leu Tyr Arg Glu Cys Leu Leu
            20                  25                  30
Ala Glu Ala Glu Gly Arg Pro Leu Arg Glu Pro Gly Ser Ser Arg Leu
        35                  40                  45
Gly Ser Pro Asp Ala Thr Arg Lys Lys Pro Lys Leu Lys Pro Gly Lys
    50                  55                  60
Ser Leu Pro Leu Gly Val Glu Glu Leu Gly Gln Leu Pro Pro Val Glu
65                  70                  75                  80
Gly Pro Gly Gly Arg Pro Leu Arg Lys Ser Phe Arg Arg Glu Leu Gly
                85                  90                  95
Gly Thr Ala Asn Ala Ala Leu Arg Arg Glu Ser Gln Gly Ser Leu Asn
            100                 105                 110
Ser Ser Ala Ser Leu Asp Leu Gly Phe Leu Ala Phe Val Ser Ser Lys
        115                 120                 125
Ser Glu Ser His Arg Lys Ser Leu Gly Ser Thr Glu Gly Glu Ser Glu
    130                 135                 140
Ser Arg Pro Gly Lys Tyr Cys Cys Val Tyr Leu Pro Asp Gly Thr Ala
145                 150                 155                 160
Ser Leu Ala Leu Ala Arg Pro Gly Leu Thr Ile Arg Asp Met Leu Ala
                165                 170                 175
Gly Ile Cys Glu Lys Arg Gly Ser Leu Tyr Leu Thr Ser Ser Leu Pro
            180                 185                 190
Gly Gly Asn Glu Gln Lys Ala Leu Val Leu Asp Gln Asp Cys Thr Val
        195                 200                 205
Leu Ala Asp Gln Glu Val Arg Leu Glu Asn Arg Ile Thr Phe Glu Leu
    210                 215                 220
Glu Leu Thr Ala Leu Glu Arg Val Val Arg Ile Ser Ala Lys Pro Thr
225                 230                 235                 240
Lys Arg Leu Gln Glu Ala Leu Gln Pro Ile Leu Glu Lys His Gly Leu
                245                 250                 255
Ser Pro Leu Glu Val Val Leu His Arg Pro Gly Glu Lys Gln Pro Leu
            260                 265                 270
Asp Leu Gly Lys Leu Val Ser Ser Val Ala Ala Gln Arg Leu Val Leu
        275                 280                 285
Asp Thr Leu Pro Gly Val Lys Ile Ser Lys Ala Arg Asp Lys Ser Pro
    290                 295                 300
Cys Arg Ser Gln Gly Cys Pro Pro Arg Thr Gln Asp Lys Ala Thr His
305                 310                 315                 320
Pro Pro Pro Ala Ser Pro Ser Ser Leu Val Lys Val Pro Ser Ser Ala
                325                 330                 335
Thr Gly Lys Arg Gln Thr Cys Asp Ile Glu Gly Leu Glu Leu Leu Asn
            340                 345                 350
Arg Val Gln Ser Ser Gly Ala His Asp Gln Arg Gly Leu Leu Arg Lys
        355                 360                 365
Glu Asp Leu Val Leu Pro Glu Phe Leu Gln Leu Pro Ala Gln Gly Pro
    370                 375                 380
Ala Pro Arg Arg Pro Thr Thr Asp Gln Ile Ser Ser Pro Ala His Arg
385                 390                 395                 400
Gly Ile Leu Glu Leu His His Arg Leu Ser Pro Leu Thr Ala Thr Gln
                405                 410                 415
Gln Ser Arg Thr Ala Ala Trp His Pro Ala Gly Arg Ala Cys His Gly
            420                 425                 430
Ser Ala Leu His Ala Leu Ser Val Pro
        435                 440

<210> 389
<211> 594
<212> PRT
<213> Homo sapiens

<400> 389
Met Pro Gly Lys Pro Lys His Leu Gly Val Pro Asn Gly Arg Met Val
 1               5                  10                  15
Leu Ala Val Ser Asp Gly Glu Leu Ser Ser Thr Thr Gly Pro Gln Gly
            20                  25                  30
Gln Gly Glu Gly Arg Gly Ser Ser Leu Ser Ile His Ser Leu Pro Ser
        35                  40                  45
Gly Pro Ser Ser Pro Phe Pro Thr Glu Glu Gln Pro Val Ala Ser Trp
    50                  55                  60
Ala Leu Ser Phe Glu Arg Leu Leu Gln Asp Pro Leu Gly Leu Ala Tyr
65                  70                  75                  80
Phe Thr Glu Phe Leu Lys Lys Glu Phe Ser Ala Glu Asn Val Thr Phe
                85                  90                  95
Trp Lys Ala Cys Glu Arg Phe Gln Gln Ile Pro Ala Ser Asp Thr Gln
            100                 105                 110
Gln Leu Ala Gln Glu Ala Arg Asn Ile Tyr Gln Glu Phe Leu Ser Ser
        115                 120                 125
Gln Ala Leu Ser Pro Val Asn Ile Asp Arg Gln Ala Trp Leu Gly Glu
    130                 135                 140
Glu Val Leu Ala Glu Pro Arg Pro Asp Met Phe Arg Ala Gln Gln Leu
145                 150                 155                 160
Gln Ile Phe Asn Leu Met Lys Phe Asp Ser Tyr Ala Arg Phe Val Lys
                165                 170                 175
Ser Pro Leu Tyr Arg Glu Cys Leu Leu Ala Glu Ala Glu Gly Arg Pro
            180                 185                 190
Leu Arg Glu Pro Gly Ser Ser Arg Leu Gly Ser Pro Asp Ala Thr Arg
        195                 200                 205
Lys Lys Pro Lys Leu Lys Pro Gly Lys Ser Leu Pro Leu Gly Val Glu
    210                 215                 220
Glu Leu Gly Gln Leu Pro Pro Val Glu Gly Pro Gly Gly Arg Pro Leu
225                 230                 235                 240
Arg Lys Ser Phe Arg Arg Glu Leu Gly Gly Thr Ala Asn Ala Ala Leu
                245                 250                 255
Arg Arg Glu Ser Gln Gly Ser Leu Asn Ser Ser Ala Ser Leu Asp Leu
            260                 265                 270
Gly Phe Leu Ala Phe Val Ser Ser Lys Ser Glu Ser His Arg Lys Ser
        275                 280                 285
Leu Gly Ser Thr Glu Gly Glu Ser Glu Ser Arg Pro Gly Lys Tyr Cys
    290                 295                 300
Cys Val Tyr Leu Pro Asp Gly Thr Ala Ser Leu Ala Leu Ala Arg Pro
305                 310                 315                 320
Gly Leu Thr Ile Arg Asp Met Leu Ala Gly Ile Cys Glu Lys Arg Gly
                325                 330                 335
Ser Leu Tyr Leu Thr Ser Ser Leu Pro Gly Gly Asn Glu Gln Lys Ala
            340                 345                 350
Leu Val Leu Asp Gln Asp Cys Thr Val Leu Ala Asp Gln Glu Val Arg
        355                 360                 365
Leu Glu Asn Arg Ile Thr Phe Glu Leu Glu Leu Thr Ala Leu Glu Arg
    370                 375                 380
Val Val Arg Ile Ser Ala Lys Pro Thr Lys Arg Leu Gln Glu Ala Leu
385                 390                 395                 400
Gln Pro Ile Leu Glu Lys His Gly Leu Ser Pro Leu Glu Val Val Leu
                405                 410                 415
His Arg Pro Gly Glu Lys Gln Pro Leu Asp Leu Gly Lys Leu Val Ser
            420                 425                 430
Ser Val Ala Ala Gln Arg Leu Val Leu Asp Thr Leu Pro Gly Val Lys
        435                 440                 445
Ile Ser Lys Ala Arg Asp Lys Ser Pro Cys Arg Ser Gln Gly Cys Pro
    450                 455                 460
Pro Arg Thr Gln Asp Lys Ala Thr His Pro Pro Pro Ala Ser Pro Ser
465                 470                 475                 480
Ser Leu Val Lys Val Pro Ser Ser Ala Thr Gly Lys Arg Gln Thr Cys
                485                 490                 495
Asp Ile Glu Gly Leu Glu Leu Leu Asn Arg Val Gln Ser Ser Gly Ala
            500                 505                 510
His Asp Gln Arg Gly Leu Leu Arg Lys Glu Asp Leu Val Leu Pro Glu
        515                 520                 525
Phe Leu Gln Leu Pro Ala Gln Gly Pro Ala Pro Arg Arg Pro Thr Thr
    530                 535                 540
Asp Gln Ile Ser Ser Pro Ala His Arg Gly Ile Leu Glu Leu His His
545                 550                 555                 560
Arg Leu Ser Pro Leu Thr Ala Thr Gln Gln Ser Arg Thr Ala Ala Trp
                565                 570                 575
His Pro Ala Gly Arg Ala Cys His Gly Ser Ala Leu His Ala Leu Ser
            580                 585                 590
Val Pro


<210> 390
<211> 1270
<212> PRT
<213> Homo sapiens

<400> 390
Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys
 1               5                  10                  15
Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln
            20                  25                  30
Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met
        35                  40                  45
Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp
    50                  55                  60
Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val
65                  70                  75                  80
Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp
                85                  90                  95
Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro
            100                 105                 110
Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly
        115                 120                 125
Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn
    130                 135                 140
Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr
145                 150                 155                 160
Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp
                165                 170                 175
Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu
            180                 185                 190
Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn
        195                 200                 205
Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg
    210                 215                 220
Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln
225                 230                 235                 240
Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val
                245                 250                 255
Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu
            260                 265                 270
Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn
        275                 280                 285
Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro
    290                 295                 300
Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro
305                 310                 315                 320
Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln
                325                 330                 335
Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu
            340                 345                 350
Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu
        355                 360                 365
Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu
    370                 375                 380
Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala
385                 390                 395                 400
Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly
                405                 410                 415
Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn
            420                 425                 430
Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile
        435                 440                 445
Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu
    450                 455                 460
Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro
465                 470                 475                 480
Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg
                485                 490                 495
Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu
            500                 505                 510
Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg
        515                 520                 525
Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala
    530                 535                 540
Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile
545                 550                 555                 560
Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu
                565                 570                 575
Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys
            580                 585                 590
Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys
        595                 600                 605
Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met
    610                 615                 620
Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu
625                 630                 635                 640
Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe
                645                 650                 655
Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met
            660                 665                 670
Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser
        675                 680                 685
Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val
    690                 695                 700
Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile
705                 710                 715                 720
Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val
                725                 730                 735
Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ser Thr Val Trp
            740                 745                 750
Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Ser
        755                 760                 765
Thr Ala Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg
    770                 775                 780
Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu
785                 790                 795                 800
Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe
                805                 810                 815
Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala
            820                 825                 830
Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu
        835                 840                 845
Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe
    850                 855                 860
Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile
865                 870                 875                 880
Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu
                885                 890                 895
Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe
            900                 905                 910
Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala
        915                 920                 925
Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg
    930                 935                 940
Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu
945                 950                 955                 960
Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr
                965                 970                 975
Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile
            980                 985                 990
Ser Leu Leu Ala Phe Gly Val Tyr Pro Asn Val Cys Tyr His Lys Glu
        995                 1000                1005
Lys Arg Lys Ile Leu Thr Thr Glu Gly Arg Asn Ala Leu Ile His Lys
    1010                1015                1020
Ser Ser Val Asn Cys Pro Phe Ser Ser Gln Asp Met Lys Tyr Pro Ser
1025                1030                1035                1040
Pro Phe Phe Val Phe Gly Glu Lys Ile Arg Thr Arg Ala Ile Ser Ala
                1045                1050                1055
Lys Gly Met Thr Leu Val Pro Pro Leu Gln Leu Leu Leu Phe Ala Ser
            1060                1065                1070
Lys Lys Val Gln Ser Asp Gly Gln Ile Val Leu Val Asp Asp Trp Ile
        1075                1080                1085
Lys Leu Gln Ile Ser His Glu Ala Ala Ala Cys Ile Thr Gly Leu Arg
    1090                1095                1100
Ala Ala Met Glu Ala Leu Val Val Glu Val Thr Lys Gln Pro Ala Ile
1105                1110                1115                1120
Ile Ser Gln Leu Asp Pro Val Asn Glu Arg Met Leu Asn Met Ile Arg
                1125                1130                1135
Gln Ile Ser Arg Pro Ser Ala Ala Gly Ile Asn Leu Met Ile Gly Ser
            1140                1145                1150
Thr Arg Tyr Gly Asp Gly Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp
        1155                1160                1165
Asn Gly Ser Gly Tyr Arg Arg Gly Gly Ser Ser Tyr Ser Gly Gly Gly
    1170                1175                1180
Tyr Gly Gly Gly Tyr Ser Ser Gly Gly Tyr Gly Ser Gly Gly Tyr Gly
1185                1190                1195                1200
Gly Ser Ala Asn Ser Phe Arg Ala Gly Tyr Gly Ala Gly Val Gly Gly
                1205                1210                1215
Gly Tyr Arg Gly Val Ser Arg Gly Gly Phe Arg Gly Asn Ser Gly Gly
            1220                1225                1230
Asp Tyr Arg Gly Pro Ser Gly Gly Tyr Arg Gly Ser Gly Gly Phe Gln
        1235                1240                1245
Arg Gly Gly Gly Arg Gly Ala Tyr Gly Thr Gly Tyr Phe Gly Gln Gly
    1250                1255                1260
Arg Gly Gly Gly Gly Tyr
1265                1270

<210> 391
<211> 1279
<212> PRT
<213> Homo sapiens

<400> 391
Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys
 1               5                  10                  15
Met Thr Pro Thr Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln
            20                  25                  30
Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met
        35                  40                  45
Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp
    50                  55                  60
Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val
65                  70                  75                  80
Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp
                85                  90                  95
Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr His His Gly Gly Pro
            100                 105                 110
Leu Leu His Ile Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly
        115                 120                 125
Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn
    130                 135                 140
Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr
145                 150                 155                 160
Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp
                165                 170                 175
Thr Leu Glu Asn Ala Lys Ala Arg Leu Ile Gln Tyr Phe Gln Lys Glu
            180                 185                 190
Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn
        195                 200                 205
Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg
    210                 215                 220
Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln
225                 230                 235                 240
Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val
                245                 250                 255
Glu Ala Tyr Thr Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu
            260                 265                 270
Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn
        275                 280                 285
Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro
    290                 295                 300
Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro
305                 310                 315                 320
Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln
                325                 330                 335
Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu
            340                 345                 350
Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu
        355                 360                 365
Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu
    370                 375                 380
Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala
385                 390                 395                 400
Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly
                405                 410                 415
Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn
            420                 425                 430
Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile
        435                 440                 445
Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu
    450                 455                 460
Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Val Leu Pro
465                 470                 475                 480
Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg
                485                 490                 495
Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu
            500                 505                 510
Ile His Glu Arg Asp Ile Asn Thr Ser Phe Leu Leu Val Val Leu Arg
        515                 520                 525
Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Phe Met Ser Ala
    530                 535                 540
Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ser
545                 550                 555                 560
Leu Lys Leu Trp Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu Asp
                565                 570                 575
Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys Lys
            580                 585                 590
Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys Asn
        595                 600                 605
Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met Ser
    610                 615                 620
Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu Leu
625                 630                 635                 640
Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe Leu
                645                 650                 655
Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met Asn
            660                 665                 670
Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser Gln
        675                 680                 685
Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val Gly
    690                 695                 700
Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile Thr
705                 710                 715                 720
Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val Lys
                725                 730                 735
Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ser Thr Val Trp Ala
            740                 745                 750
Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Ser Thr
        755                 760                 765
Ala Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg Leu
    770                 775                 780
Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu Ile
785                 790                 795                 800
Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe Leu
                805                 810                 815
Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala Glu
            820                 825                 830
His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu Thr
        835                 840                 845
Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe Gly
    850                 855                 860
Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile Cys
865                 870                 875                 880
Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Val Asn Glu Gly
                885                 890                 895
Lys Gln Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe Ser
            900                 905                 910
Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala Arg
        915                 920                 925
Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg Leu
    930                 935                 940
Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu Lys
945                 950                 955                 960
Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr Gln
                965                 970                 975
Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile Ser
            980                 985                 990
Leu Leu Ala Phe Gly Val Tyr Pro Asn Val Cys Tyr His Lys Glu Lys
        995                 1000                1005
Arg Lys Ile Leu Thr Thr Glu Gly Arg Asn Ala Leu Ile His Lys Ser
    1010                1015                1020
Ser Val Asn Cys Pro Phe Ser Ser Gln Asp Met Asn Tyr Pro Ser Pro
1025                1030                1035                1040
Phe Phe Val Phe Gly Glu Lys Ile Arg Thr Arg Ala Ile Ser Ala Lys
                1045                1050                1055
Gly Met Thr Leu Val Pro Pro Leu Gln Leu Leu Leu Phe Ala Ser Lys
            1060                1065                1070
Lys Val Gln Ser Asp Gly Gln Ile Val Leu Val Asp Asp Trp Ile Lys
        1075                1080                1085
Leu Gln Ile Ser His Glu Ala Ala Ala Cys Ile Thr Gly Leu Arg Ala
    1090                1095                1100
Ala Met Glu Ala Leu Val Val Glu Val Thr Lys Gln Pro Ala Ile Ile
1105                1110                1115                1120
Ser Gln Leu Asp Pro Val Asn Glu Arg Met Leu Asn Met Ile Arg Gln
                1125                1130                1135
Ile Ser Glu Pro Ser Ala Ala Gly Ile Asn Leu Met Ile Gly Ser Thr
            1140                1145                1150
Arg Tyr Gly Asp Gly Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp Asn
        1155                1160                1165
Gly Ser Gly Tyr Arg Arg Gly Gly Ser Ser Tyr Ser Gly Gly Gly Tyr
    1170                1175                1180
Gly Gly Gly Tyr Ser Ser Gly Gly Tyr Gly Ser Gly Gly Tyr Gly Gly
1185                1190                1195                1200
Ser Ala Thr Pro Ser Gly Arg Ile Cys Ala Gly Val Gly Gly Gly Tyr
                1205                1210                1215
Arg Gly Val Ser Arg Gly Gly Phe Arg Gly Asn Ser Gly Gly Asp Tyr
            1220                1225                1230
Arg Gly Pro Ser Gly Gly Tyr Arg Gly Ser Gly Gly Phe Gln Arg Gly
        1235                1240                1245
Gly Gly Arg Gly Ala Tyr Gly Thr Gly Tyr Leu Asp Ile Glu Glu Glu
    1250                1255                1260
Val Ala Ala Ile Lys Leu Gly Tyr Val Ser Ser Val Cys Arg Gln
1265                1270                1275

<210> 392
<211> 1280
<212> PRT
<213> Homo sapiens

<400> 392
Ile Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg
 1               5                  10                  15
Lys Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg
            20                  25                  30
Gln Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly
        35                  40                  45
Met Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg
    50                  55                  60
Asp Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu
65                  70                  75                  80
Val Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro
                85                  90                  95
Asp Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly
            100                 105                 110
Pro Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val
        115                 120                 125
Gly Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala
    130                 135                 140
Asn Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala
145                 150                 155                 160
Thr Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn
                165                 170                 175
Trp Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys
            180                 185                 190
Glu Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His
        195                 200                 205
Asn Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly
    210                 215                 220
Arg Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala
225                 230                 235                 240
Gln Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val
                245                 250                 255
Val Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val
            260                 265                 270
Glu Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln
        275                 280                 285
Asn Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp
    290                 295                 300
Pro Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu
305                 310                 315                 320
Pro Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro
                325                 330                 335
Gln Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro
            340                 345                 350
Leu Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu
        355                 360                 365
Leu Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln
    370                 375                 380
Glu Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu
385                 390                 395                 400
Ala Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys
                405                 410                 415
Gly Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln
            420                 425                 430
Asn Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg
        435                 440                 445
Ile Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu
    450                 455                 460
Glu Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Val Leu
465                 470                 475                 480
Pro Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu
                485                 490                 495
Arg Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp
            500                 505                 510
Glu Ile His Glu Arg Asp Ile Asn Thr Ser Phe Leu Leu Val Val Leu
        515                 520                 525
Arg Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Phe Met Ser
    530                 535                 540
Ala Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro
545                 550                 555                 560
Ser Leu Lys Leu Trp Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu
                565                 570                 575
Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys
            580                 585                 590
Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys
        595                 600                 605
Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met
    610                 615                 620
Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu
625                 630                 635                 640
Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe
                645                 650                 655
Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met
            660                 665                 670
Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser
        675                 680                 685
Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val
    690                 695                 700
Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile
705                 710                 715                 720
Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val
                725                 730                 735
Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ser Thr Val Trp
            740                 745                 750
Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Ser
        755                 760                 765
Thr Ala Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg
    770                 775                 780
Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu
785                 790                 795                 800
Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe
                805                 810                 815
Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala
            820                 825                 830
Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu
        835                 840                 845
Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe
    850                 855                 860
Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile
865                 870                 875                 880
Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Val Asn Glu
                885                 890                 895
Gly Lys Gln Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe
            900                 905                 910
Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala
        915                 920                 925
Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg
    930                 935                 940
Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu
945                 950                 955                 960
Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr
                965                 970                 975
Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile
            980                 985                 990
Ser Leu Leu Ala Phe Gly Val Tyr Pro Asn Val Cys Tyr His Lys Glu
        995                 1000                1005
Lys Arg Lys Ile Leu Thr Thr Glu Gly Arg Asn Ala Leu Ile His Lys
    1010                1015                1020
Ser Ser Val Asn Cys Pro Phe Ser Ser Gln Asp Met Asn Tyr Pro Ser
1025                1030                1035                1040
Pro Phe Phe Val Phe Gly Glu Lys Ile Arg Thr Arg Ala Ile Ser Ala
                1045                1050                1055
Lys Gly Met Thr Leu Val Pro Pro Leu Gln Leu Leu Leu Phe Ala Ser
            1060                1065                1070
Lys Lys Val Gln Ser Asp Gly Gln Ile Val Leu Val Asp Asp Trp Ile
        1075                1080                1085
Lys Leu Gln Ile Ser His Glu Ala Ala Ala Cys Ile Thr Gly Leu Arg
    1090                1095                1100
Ala Ala Met Glu Ala Leu Val Val Glu Val Thr Lys Gln Pro Ala Ile
1105                1110                1115                1120
Ile Ser Gln Leu Asp Pro Val Asn Glu Arg Met Leu Asn Met Ile Arg
                1125                1130                1135
Gln Ile Ser Glu Pro Ser Ala Ala Gly Ile Asn Leu Met Ile Gly Ser
            1140                1145                1150
Thr Arg Tyr Gly Asp Gly Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp
        1155                1160                1165
Asn Gly Ser Gly Tyr Arg Arg Gly Gly Ser Ser Tyr Ser Gly Gly Gly
    1170                1175                1180
Tyr Gly Gly Gly Tyr Ser Ser Gly Gly Tyr Gly Ser Gly Gly Tyr Gly
1185                1190                1195                1200
Gly Ser Ala Thr Pro Ser Gly Arg Ile Cys Ala Gly Val Gly Gly Gly
                1205                1210                1215
Tyr Arg Gly Val Ser Arg Gly Gly Phe Arg Gly Asn Ser Gly Gly Asp
            1220                1225                1230
Tyr Arg Gly Pro Ser Gly Gly Tyr Arg Gly Ser Gly Gly Phe Gln Arg
        1235                1240                1245
Gly Gly Gly Arg Gly Ala Tyr Gly Thr Gly Tyr Leu Asp Ile Glu Glu
    1250                1255                1260
Glu Val Ala Ala Ile Lys Leu Gly Tyr Val Ser Ser Val Cys Arg Gln
1265                1270                1275                1280

<210> 393
<211> 1279
<212> PRT
<213> Homo sapiens

<400> 393
Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys
 1               5                  10                  15
Met Thr Pro Thr Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln
            20                  25                  30
Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met
        35                  40                  45
Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp
    50                  55                  60
Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val
65                  70                  75                  80
Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp
                85                  90                  95
Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr His His Gly Gly Pro
            100                 105                 110
Leu Leu His Ile Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly
        115                 120                 125
Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn
    130                 135                 140
Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr
145                 150                 155                 160
Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp
                165                 170                 175
Thr Leu Glu Asn Ala Lys Ala Arg Leu Ile Gln Tyr Phe Gln Lys Glu
            180                 185                 190
Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn
        195                 200                 205
Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg
    210                 215                 220
Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln
225                 230                 235                 240
Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val
                245                 250                 255
Glu Ala Tyr Thr Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu
            260                 265                 270
Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn
        275                 280                 285
Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro
    290                 295                 300
Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro
305                 310                 315                 320
Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln
                325                 330                 335
Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu
            340                 345                 350
Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu
        355                 360                 365
Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu
    370                 375                 380
Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala
385                 390                 395                 400
Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly
                405                 410                 415
Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn
            420                 425                 430
Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile
        435                 440                 445
Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu
    450                 455                 460
Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Val Leu Pro
465                 470                 475                 480
Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg
                485                 490                 495
Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu
            500                 505                 510
Ile His Glu Arg Asp Ile Asn Thr Ser Phe Leu Leu Val Val Leu Arg
        515                 520                 525
Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Phe Met Ser Ala
    530                 535                 540
Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ser
545                 550                 555                 560
Leu Lys Leu Trp Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu Asp
                565                 570                 575
Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys Lys
            580                 585                 590
Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys Asn
        595                 600                 605
Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met Ser
    610                 615                 620
Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu Leu
625                 630                 635                 640
Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe Leu
                645                 650                 655
Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met Asn
            660                 665                 670
Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser Gln
        675                 680                 685
Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val Gly
    690                 695                 700
Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile Thr
705                 710                 715                 720
Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val Lys
                725                 730                 735
Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ser Thr Val Trp Ala
            740                 745                 750
Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Ser Thr
        755                 760                 765
Ala Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg Leu
    770                 775                 780
Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu Ile
785                 790                 795                 800
Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe Leu
                805                 810                 815
Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala Glu
            820                 825                 830
His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu Thr
        835                 840                 845
Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe Gly
    850                 855                 860
Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile Cys
865                 870                 875                 880
Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Val Asn Glu Gly
                885                 890                 895
Lys Gln Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe Ser
            900                 905                 910
Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala Arg
        915                 920                 925
Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg Leu
    930                 935                 940
Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu Lys
945                 950                 955                 960
Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr Gln
                965                 970                 975
Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile Ser
            980                 985                 990
Leu Leu Ala Phe Gly Val Tyr Pro Asn Val Cys Tyr His Lys Glu Lys
        995                 1000                1005
Arg Lys Ile Leu Thr Thr Glu Gly Arg Asn Ala Leu Ile His Lys Ser
    1010                1015                1020
Ser Val Asn Cys Pro Phe Ser Ser Gln Asp Met Asn Tyr Pro Ser Pro
1025                1030                1035                1040
Phe Phe Val Phe Gly Glu Lys Ile Arg Thr Arg Ala Ile Ser Ala Lys
                1045                1050                1055
Gly Met Thr Leu Val Pro Pro Leu Gln Leu Leu Leu Phe Ala Ser Lys
            1060                1065                1070
Lys Val Gln Ser Asp Gly Gln Ile Val Leu Val Asp Asp Trp Ile Lys
        1075                1080                1085
Leu Gln Ile Ser His Glu Ala Ala Ala Cys Ile Thr Gly Leu Arg Ala
    1090                1095                1100
Ala Met Glu Ala Leu Val Val Glu Val Thr Lys Gln Pro Ala Ile Ile
1105                1110                1115                1120
Ser Gln Leu Asp Pro Val Asn Glu Arg Met Leu Asn Met Ile Arg Gln
                1125                1130                1135
Ile Ser Glu Pro Ser Ala Ala Gly Ile Asn Leu Met Ile Gly Ser Thr
            1140                1145                1150
Arg Tyr Gly Asp Gly Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp Asn
        1155                1160                1165
Gly Ser Gly Tyr Arg Arg Gly Gly Ser Ser Tyr Ser Gly Gly Gly Tyr
    1170                1175                1180
Gly Gly Gly Tyr Ser Ser Gly Gly Tyr Gly Ser Gly Gly Tyr Gly Gly
1185                1190                1195                1200
Ser Ala Thr Pro Ser Gly Arg Ile Cys Ala Gly Val Gly Gly Gly Tyr
                1205                1210                1215
Arg Gly Val Ser Arg Gly Gly Phe Arg Gly Asn Ser Gly Gly Asp Tyr
            1220                1225                1230
Arg Gly Pro Ser Gly Gly Tyr Arg Gly Ser Gly Gly Phe Gln Arg Gly
        1235                1240                1245
Gly Gly Arg Gly Ala Tyr Gly Thr Gly Tyr Leu Asp Ile Glu Glu Glu
    1250                1255                1260
Val Ala Ala Ile Lys Leu Gly Tyr Val Ser Ser Val Cys Arg Gln
1265                1270                1275

<210> 394
<211> 1270
<212> PRT
<213> Homo sapiens

<400> 394
Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys
 1               5                  10                  15
Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln
            20                  25                  30
Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met
        35                  40                  45
Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp
    50                  55                  60
Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val
65                  70                  75                  80
Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp
                85                  90                  95
Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro
            100                 105                 110
Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly
        115                 120                 125
Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn
    130                 135                 140
Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr
145                 150                 155                 160
Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp
                165                 170                 175
Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu
            180                 185                 190
Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn
        195                 200                 205
Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg
    210                 215                 220
Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln
225                 230                 235                 240
Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val
                245                 250                 255
Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu
            260                 265                 270
Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn
        275                 280                 285
Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro
    290                 295                 300
Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro
305                 310                 315                 320
Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln
                325                 330                 335
Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu
            340                 345                 350
Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu
        355                 360                 365
Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu
    370                 375                 380
Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala
385                 390                 395                 400
Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly
                405                 410                 415
Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn
            420                 425                 430
Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile
        435                 440                 445
Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu
    450                 455                 460
Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro
465                 470                 475                 480
Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg
                485                 490                 495
Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu
            500                 505                 510
Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg
        515                 520                 525
Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala
    530                 535                 540
Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile
545                 550                 555                 560
Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu
                565                 570                 575
Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys
            580                 585                 590
Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys
        595                 600                 605
Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met
    610                 615                 620
Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu
625                 630                 635                 640
Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe
                645                 650                 655
Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met
            660                 665                 670
Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser
        675                 680                 685
Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val
    690                 695                 700
Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile
705                 710                 715                 720
Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val
                725                 730                 735
Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ser Thr Val Trp
            740                 745                 750
Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Ser
        755                 760                 765
Thr Ala Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg
    770                 775                 780
Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu
785                 790                 795                 800
Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe
                805                 810                 815
Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala
            820                 825                 830
Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu
        835                 840                 845
Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe
    850                 855                 860
Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile
865                 870                 875                 880
Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu
                885                 890                 895
Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe
            900                 905                 910
Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala
        915                 920                 925
Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg
    930                 935                 940
Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu
945                 950                 955                 960
Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr
                965                 970                 975
Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile
            980                 985                 990
Ser Leu Leu Ala Phe Gly Val Tyr Pro Asn Val Cys Tyr His Lys Glu
        995                 1000                1005
Lys Arg Lys Ile Leu Thr Thr Glu Gly Arg Asn Ala Leu Ile His Lys
    1010                1015                1020
Ser Ser Val Asn Cys Pro Phe Ser Ser Gln Asp Met Lys Tyr Pro Ser
1025                1030                1035                1040
Pro Phe Phe Val Phe Gly Glu Lys Ile Arg Thr Arg Ala Ile Ser Ala
                1045                1050                1055
Lys Gly Met Thr Leu Val Pro Pro Leu Gln Leu Leu Leu Phe Ala Ser
            1060                1065                1070
Lys Lys Val Gln Ser Asp Gly Gln Ile Val Leu Val Asp Asp Trp Ile
        1075                1080                1085
Lys Leu Gln Ile Ser His Glu Ala Ala Ala Cys Ile Thr Gly Leu Arg
    1090                1095                1100
Ala Ala Met Glu Ala Leu Val Val Glu Val Thr Lys Gln Pro Ala Ile
1105                1110                1115                1120
Ile Ser Gln Leu Asp Pro Val Asn Glu Arg Met Leu Asn Met Ile Arg
                1125                1130                1135
Gln Ile Ser Arg Pro Ser Ala Ala Gly Ile Asn Leu Met Ile Gly Ser
            1140                1145                1150
Thr Arg Tyr Gly Asp Gly Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp
        1155                1160                1165
Asn Gly Ser Gly Tyr Arg Arg Gly Gly Ser Ser Tyr Ser Gly Gly Gly
    1170                1175                1180
Tyr Gly Gly Gly Tyr Ser Ser Gly Gly Tyr Gly Ser Gly Gly Tyr Gly
1185                1190                1195                1200
Gly Ser Ala Asn Ser Phe Arg Ala Gly Tyr Gly Ala Gly Val Gly Gly
                1205                1210                1215
Gly Tyr Arg Gly Val Ser Arg Gly Gly Phe Arg Gly Asn Ser Gly Gly
            1220                1225                1230
Asp Tyr Arg Gly Pro Ser Gly Gly Tyr Arg Gly Ser Gly Gly Phe Gln
        1235                1240                1245
Arg Gly Gly Gly Arg Gly Ala Tyr Gly Thr Gly Tyr Phe Gly Gln Gly
    1250                1255                1260
Arg Gly Gly Gly Gly Tyr
1265                1270

<210> 395
<211> 539
<212> PRT
<213> Homo sapiens

<400> 395
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys
 1               5                  10                  15
Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly
            20                  25                  30
His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly
        35                  40                  45
Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn
    50                  55                  60
Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg
65                  70                  75                  80
Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln
                85                  90                  95
Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr
            100                 105                 110
Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg
        115                 120                 125
Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro
    130                 135                 140
His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg
145                 150                 155                 160
Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala
                165                 170                 175
Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe
            180                 185                 190
Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu
        195                 200                 205
Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe
    210                 215                 220
Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser
225                 230                 235                 240
Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp
                245                 250                 255
Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly
            260                 265                 270
Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp
        275                 280                 285
Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu
    290                 295                 300
Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln
305                 310                 315                 320
Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr
                325                 330                 335
Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp
            340                 345                 350
Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val
        355                 360                 365
Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu
    370                 375                 380
Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu
385                 390                 395                 400
Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu
                405                 410                 415
Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
            420                 425                 430
Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg
        435                 440                 445
Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg
    450                 455                 460
Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu
465                 470                 475                 480
Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu
                485                 490                 495
Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr
            500                 505                 510
Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu
        515                 520                 525
Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro
    530                 535

<210> 396
<211> 539
<212> PRT
<213> Homo sapiens

<400> 396
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys
 1               5                  10                  15
Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly
            20                  25                  30
His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly
        35                  40                  45
Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn
    50                  55                  60
Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg
65                  70                  75                  80
Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln
                85                  90                  95
Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr
            100                 105                 110
Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg
        115                 120                 125
Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro
    130                 135                 140
His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg
145                 150                 155                 160
Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala
                165                 170                 175
Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe
            180                 185                 190
Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu
        195                 200                 205
Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe
    210                 215                 220
Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser
225                 230                 235                 240
Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp
                245                 250                 255
Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly
            260                 265                 270
Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp
        275                 280                 285
Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu
    290                 295                 300
Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln
305                 310                 315                 320
Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr
                325                 330                 335
Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp
            340                 345                 350
Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val
        355                 360                 365
Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu
    370                 375                 380
Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu
385                 390                 395                 400
Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu
                405                 410                 415
Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
            420                 425                 430
Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg
        435                 440                 445
Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg
    450                 455                 460
Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu
465                 470                 475                 480
Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu
                485                 490                 495
Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr
            500                 505                 510
Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu
        515                 520                 525
Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro
    530                 535

<210> 397
<211> 539
<212> PRT
<213> Homo sapiens

<400> 397
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys
 1               5                  10                  15
Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly
            20                  25                  30
His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly
        35                  40                  45
Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn
    50                  55                  60
Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg
65                  70                  75                  80
Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln
                85                  90                  95
Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr
            100                 105                 110
Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg
        115                 120                 125
Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro
    130                 135                 140
His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg
145                 150                 155                 160
Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala
                165                 170                 175
Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe
            180                 185                 190
Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu
        195                 200                 205
Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe
    210                 215                 220
Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser
225                 230                 235                 240
Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp
                245                 250                 255
Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly
            260                 265                 270
Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp
        275                 280                 285
Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu
    290                 295                 300
Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln
305                 310                 315                 320
Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr
                325                 330                 335
Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp
            340                 345                 350
Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val
        355                 360                 365
Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu
    370                 375                 380
Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu
385                 390                 395                 400
Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu
                405                 410                 415
Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
            420                 425                 430
Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg
        435                 440                 445
Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg
    450                 455                 460
Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu
465                 470                 475                 480
Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu
                485                 490                 495
Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr
            500                 505                 510
Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu
        515                 520                 525
Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro
    530                 535

<210> 398
<211> 539
<212> PRT
<213> Homo sapiens

<400> 398
Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys
 1               5                  10                  15
Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly
            20                  25                  30
His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly
        35                  40                  45
Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn
    50                  55                  60
Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg
65                  70                  75                  80
Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln
                85                  90                  95
Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr
            100                 105                 110
Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg
        115                 120                 125
Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro
    130                 135                 140
His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg
145                 150                 155                 160
Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala
                165                 170                 175
Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe
            180                 185                 190
Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu
        195                 200                 205
Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe
    210                 215                 220
Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser
225                 230                 235                 240
Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp
                245                 250                 255
Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly
            260                 265                 270
Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp
        275                 280                 285
Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu
    290                 295                 300
Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln
305                 310                 315                 320
Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr
                325                 330                 335
Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp
            340                 345                 350
Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val
        355                 360                 365
Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu
    370                 375                 380
Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu
385                 390                 395                 400
Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu
                405                 410                 415
Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
            420                 425                 430
Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg
        435                 440                 445
Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg
    450                 455                 460
Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu
465                 470                 475                 480
Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu
                485                 490                 495
Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr
            500                 505                 510
Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu
        515                 520                 525
Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro
    530                 535

<210> 399
<211> 270
<212> PRT
<213> Homo sapiens

<400> 399
Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly
 1               5                  10                  15
Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro
            20                  25                  30
Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro
        35                  40                  45
Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe
    50                  55                  60
Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile
65                  70                  75                  80
Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp
                85                  90                  95
Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp
            100                 105                 110
Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val
        115                 120                 125
Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe
    130                 135                 140
Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu
145                 150                 155                 160
Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro
                165                 170                 175
Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly
            180                 185                 190
Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala
        195                 200                 205
Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly
    210                 215                 220
Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser
225                 230                 235                 240
Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr
                245                 250                 255
Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu
            260                 265                 270

<210> 400
<211> 270
<212> PRT
<213> Homo sapiens

<400> 400
Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly
 1               5                  10                  15
Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro
            20                  25                  30
Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro
        35                  40                  45
Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe
    50                  55                  60
Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile
65                  70                  75                  80
Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp
                85                  90                  95
Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp
            100                 105                 110
Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val
        115                 120                 125
Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe
    130                 135                 140
Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu
145                 150                 155                 160
Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro
                165                 170                 175
Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly
            180                 185                 190
Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala
        195                 200                 205
Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly
    210                 215                 220
Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser
225                 230                 235                 240
Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr
                245                 250                 255
Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu
            260                 265                 270

<210> 401
<211> 270
<212> PRT
<213> Homo sapiens

<400> 401
Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly
 1               5                  10                  15
Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro
            20                  25                  30
Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro
        35                  40                  45
Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe
    50                  55                  60
Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile
65                  70                  75                  80
Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp
                85                  90                  95
Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp
            100                 105                 110
Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val
        115                 120                 125
Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe
    130                 135                 140
Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu
145                 150                 155                 160
Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro
                165                 170                 175
Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly
            180                 185                 190
Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala
        195                 200                 205
Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly
    210                 215                 220
Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser
225                 230                 235                 240
Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr
                245                 250                 255
Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu
            260                 265                 270

<210> 402
<211> 98
<212> PRT
<213> Homo sapiens

<400> 402
Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly
 1               5                  10                  15
Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro
            20                  25                  30
Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro
        35                  40                  45
Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe
    50                  55                  60
Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile
65                  70                  75                  80
Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp
                85                  90                  95
Met Thr


<210> 403
<211> 270
<212> PRT
<213> Homo sapiens

<400> 403
Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly
 1               5                  10                  15
Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro
            20                  25                  30
Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro
        35                  40                  45
Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe
    50                  55                  60
Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile
65                  70                  75                  80
Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp
                85                  90                  95
Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp
            100                 105                 110
Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val
        115                 120                 125
Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe
    130                 135                 140
Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu
145                 150                 155                 160
Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro
                165                 170                 175
Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly
            180                 185                 190
Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala
        195                 200                 205
Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly
    210                 215                 220
Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser
225                 230                 235                 240
Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr
                245                 250                 255
Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu
            260                 265                 270

<210> 404
<211> 270
<212> PRT
<213> Homo sapiens

<400> 404
Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly
 1               5                  10                  15
Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro
            20                  25                  30
Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro
        35                  40                  45
Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe
    50                  55                  60
Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile
65                  70                  75                  80
Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp
                85                  90                  95
Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp
            100                 105                 110
Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val
        115                 120                 125
Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe
    130                 135                 140
Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu
145                 150                 155                 160
Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro
                165                 170                 175
Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly
            180                 185                 190
Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala
        195                 200                 205
Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly
    210                 215                 220
Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser
225                 230                 235                 240
Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr
                245                 250                 255
Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu
            260                 265                 270

<210> 405
<211> 560
<212> PRT
<213> Homo sapiens

<400> 405
Met Pro Gln Thr Arg Ser Gln Ala Gln Ala Thr Ile Ser Phe Pro Lys
 1               5                  10                  15
Arg Lys Leu Ser Arg Ala Leu Asn Lys Ala Lys Asn Ser Ser Asp Ala
            20                  25                  30
Lys Leu Glu Pro Thr Asn Val Gln Thr Val Thr Cys Ser Pro Arg Val
        35                  40                  45
Lys Ala Leu Pro Leu Ser Pro Arg Lys Arg Leu Gly Asp Asp Asn Leu
    50                  55                  60
Cys Asn Thr Pro His Leu Pro Pro Cys Ser Pro Pro Lys Gln Gly Lys
65                  70                  75                  80
Lys Glu Asn Gly Pro Pro His Ser His Thr Leu Lys Gly Arg Arg Leu
                85                  90                  95
Val Phe Asp Asn Gln Leu Thr Ile Lys Ser Pro Ser Lys Arg Glu Leu
            100                 105                 110
Ala Lys Val His Gln Asn Lys Ile Leu Ser Ser Val Arg Lys Ser Gln
        115                 120                 125
Glu Ile Thr Thr Asn Ser Glu Gln Arg Cys Pro Leu Lys Lys Glu Ser
    130                 135                 140
Ala Cys Val Arg Leu Phe Lys Gln Glu Gly Thr Cys Tyr Gln Gln Ala
145                 150                 155                 160
Lys Leu Val Leu Asn Thr Ala Val Pro Asp Arg Leu Pro Ala Arg Glu
                165                 170                 175
Arg Glu Met Asp Val Ile Arg Asn Phe Leu Arg Glu His Ile Cys Gly
            180                 185                 190
Lys Lys Ala Gly Ser Leu Tyr Leu Ser Gly Ala Pro Gly Thr Gly Lys
        195                 200                 205
Thr Ala Cys Leu Ser Arg Ile Leu Gln Asp Leu Lys Lys Glu Leu Lys
    210                 215                 220
Gly Phe Lys Thr Ile Met Leu Asn Cys Met Ser Leu Arg Thr Ala Gln
225                 230                 235                 240
Ala Val Phe Pro Ala Ile Ala Gln Glu Ile Cys Gln Glu Glu Val Ser
                245                 250                 255
Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His Met Thr
            260                 265                 270
Ala Glu Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met Asp Gln
        275                 280                 285
Leu Asp Ser Lys Gly Gln Asp Val Leu Tyr Thr Leu Phe Glu Trp Pro
    290                 295                 300
Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn Thr Leu
305                 310                 315                 320
Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu Lys Cys
                325                 330                 335
Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln Ile Val
            340                 345                 350
Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln Val Leu
        355                 360                 365
Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala Val Ser
    370                 375                 380
Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile Glu Ile
385                 390                 395                 400
Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu Ser Glu
                405                 410                 415
Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly Leu Ile
            420                 425                 430
His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met Thr Leu
        435                 440                 445
Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys Ile Leu
    450                 455                 460
Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys Glu Val
465                 470                 475                 480
Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg Lys Gln
                485                 490                 495
Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser Gly Leu
            500                 505                 510
Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu Thr Arg
        515                 520                 525
Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu His Ala
    530                 535                 540
Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly Leu Pro
545                 550                 555                 560

<210> 406
<211> 560
<212> PRT
<213> Homo sapiens

<400> 406
Met Pro Gln Thr Arg Ser Gln Ala Gln Ala Thr Ile Ser Phe Pro Lys
 1               5                  10                  15
Arg Lys Leu Ser Arg Ala Leu Asn Lys Ala Lys Asn Ser Ser Asp Ala
            20                  25                  30
Lys Leu Glu Pro Thr Asn Val Gln Thr Val Thr Cys Ser Pro Arg Val
        35                  40                  45
Lys Ala Leu Pro Leu Ser Pro Arg Lys Arg Leu Gly Asp Asp Asn Leu
    50                  55                  60
Cys Asn Thr Pro His Leu Pro Pro Cys Ser Pro Pro Lys Gln Gly Lys
65                  70                  75                  80
Lys Glu Asn Gly Pro Pro His Ser His Thr Leu Lys Gly Arg Arg Leu
                85                  90                  95
Val Phe Asp Asn Gln Leu Thr Ile Lys Ser Pro Ser Lys Arg Glu Leu
            100                 105                 110
Ala Lys Val His Gln Asn Lys Ile Leu Ser Ser Val Arg Lys Ser Gln
        115                 120                 125
Glu Ile Thr Thr Asn Ser Glu Gln Arg Cys Pro Leu Lys Lys Glu Ser
    130                 135                 140
Ala Cys Val Arg Leu Phe Lys Gln Glu Gly Thr Cys Tyr Gln Gln Ala
145                 150                 155                 160
Lys Leu Val Leu Asn Thr Ala Val Pro Asp Arg Leu Pro Ala Arg Glu
                165                 170                 175
Arg Glu Met Asp Val Ile Arg Asn Phe Leu Arg Glu His Ile Cys Gly
            180                 185                 190
Lys Lys Ala Gly Ser Leu Tyr Leu Ser Gly Ala Pro Gly Thr Gly Lys
        195                 200                 205
Thr Ala Cys Leu Ser Arg Ile Leu Gln Asp Leu Lys Lys Glu Leu Lys
    210                 215                 220
Gly Phe Lys Thr Ile Met Leu Asn Cys Met Ser Leu Arg Thr Ala Gln
225                 230                 235                 240
Ala Val Phe Pro Ala Ile Ala Gln Glu Ile Cys Gln Glu Glu Val Ser
                245                 250                 255
Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His Met Thr
            260                 265                 270
Ala Glu Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met Asp Gln
        275                 280                 285
Leu Asp Ser Lys Gly Gln Asp Val Leu Tyr Thr Leu Phe Glu Trp Pro
    290                 295                 300
Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn Thr Leu
305                 310                 315                 320
Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu Lys Cys
                325                 330                 335
Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln Ile Val
            340                 345                 350
Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln Val Leu
        355                 360                 365
Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala Val Ser
    370                 375                 380
Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile Glu Ile
385                 390                 395                 400
Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu Ser Glu
                405                 410                 415
Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly Leu Ile
            420                 425                 430
His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met Thr Leu
        435                 440                 445
Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys Ile Leu
    450                 455                 460
Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys Glu Val
465                 470                 475                 480
Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg Lys Gln
                485                 490                 495
Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser Gly Leu
            500                 505                 510
Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu Thr Arg
        515                 520                 525
Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu His Ala
    530                 535                 540
Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly Leu Pro
545                 550                 555                 560

<210> 407
<211> 306
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(306)
<223> Xaa = Any Amino Acid

<400> 407
Val Ser Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His
 1               5                  10                  15
Met Thr Ala Xaa Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met
            20                  25                  30
Asp Gln Leu Asp Ser Lys Xaa Gln Asp Val Leu Tyr Thr Leu Phe Glu
        35                  40                  45
Trp Pro Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn
    50                  55                  60
Thr Leu Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu
65                  70                  75                  80
Lys Cys Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln
                85                  90                  95
Ile Val Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln
            100                 105                 110
Val Leu Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala
        115                 120                 125
Val Ser Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile
    130                 135                 140
Glu Ile Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu
145                 150                 155                 160
Ser Glu Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly
                165                 170                 175
Leu Ile His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met
            180                 185                 190
Thr Leu Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys
        195                 200                 205
Ile Leu Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys
    210                 215                 220
Glu Val Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg
225                 230                 235                 240
Lys Gln Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser
                245                 250                 255
Gly Leu Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu
            260                 265                 270
Thr Arg Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu
        275                 280                 285
His Ala Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly
    290                 295                 300
Leu Pro
305

<210> 408
<211> 560
<212> PRT
<213> Homo sapiens

<400> 408
Met Pro Gln Thr Arg Ser Gln Ala Gln Ala Thr Ile Ser Phe Pro Lys
 1               5                  10                  15
Arg Lys Leu Ser Arg Ala Leu Asn Lys Ala Lys Asn Ser Ser Asp Ala
            20                  25                  30
Lys Leu Glu Pro Thr Asn Val Gln Thr Val Thr Cys Ser Pro Arg Val
        35                  40                  45
Lys Ala Leu Pro Leu Ser Pro Arg Lys Arg Leu Gly Asp Asp Asn Leu
    50                  55                  60
Cys Asn Thr Pro His Leu Pro Pro Cys Ser Pro Pro Lys Gln Gly Lys
65                  70                  75                  80
Lys Glu Asn Gly Pro Pro His Ser His Thr Leu Lys Gly Arg Arg Leu
                85                  90                  95
Val Phe Asp Asn Gln Leu Thr Ile Lys Ser Pro Ser Lys Arg Glu Leu
            100                 105                 110
Ala Lys Val His Gln Asn Lys Ile Leu Ser Ser Val Arg Lys Ser Gln
        115                 120                 125
Glu Ile Thr Thr Asn Ser Glu Gln Arg Cys Pro Leu Lys Lys Glu Ser
    130                 135                 140
Ala Cys Val Arg Leu Phe Lys Gln Glu Gly Thr Cys Tyr Gln Gln Ala
145                 150                 155                 160
Lys Leu Val Leu Asn Thr Ala Val Pro Asp Arg Leu Pro Ala Arg Glu
                165                 170                 175
Arg Glu Met Asp Val Ile Arg Asn Phe Leu Arg Glu His Ile Cys Gly
            180                 185                 190
Lys Lys Ala Gly Ser Leu Tyr Leu Ser Gly Ala Pro Gly Thr Gly Lys
        195                 200                 205
Thr Ala Cys Leu Ser Arg Ile Leu Gln Asp Leu Lys Lys Glu Leu Lys
    210                 215                 220
Gly Phe Lys Thr Ile Met Leu Asn Cys Met Ser Leu Arg Thr Ala Gln
225                 230                 235                 240
Ala Val Phe Pro Ala Ile Ala Gln Glu Ile Cys Gln Glu Glu Val Ser
                245                 250                 255
Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His Met Thr
            260                 265                 270
Ala Glu Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met Asp Gln
        275                 280                 285
Leu Asp Ser Lys Gly Gln Asp Val Leu Tyr Thr Leu Phe Glu Trp Pro
    290                 295                 300
Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn Thr Leu
305                 310                 315                 320
Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu Lys Cys
                325                 330                 335
Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln Ile Val
            340                 345                 350
Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln Val Leu
        355                 360                 365
Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala Val Ser
    370                 375                 380
Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile Glu Ile
385                 390                 395                 400
Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu Ser Glu
                405                 410                 415
Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly Leu Ile
            420                 425                 430
His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met Thr Leu
        435                 440                 445
Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys Ile Leu
    450                 455                 460
Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys Glu Val
465                 470                 475                 480
Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg Lys Gln
                485                 490                 495
Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser Gly Leu
            500                 505                 510
Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu Thr Arg
        515                 520                 525
Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu His Ala
    530                 535                 540
Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly Leu Pro
545                 550                 555                 560

<210> 409
<211> 560
<212> PRT
<213> Homo sapiens

<400> 409
Met Pro Gln Thr Arg Ser Gln Ala Gln Ala Thr Ile Ser Phe Pro Lys
 1               5                  10                  15
Arg Lys Leu Ser Arg Ala Leu Asn Lys Ala Lys Asn Ser Ser Asp Ala
            20                  25                  30
Lys Leu Glu Pro Thr Asn Val Gln Thr Val Thr Cys Ser Pro Arg Val
        35                  40                  45
Lys Ala Leu Pro Leu Ser Pro Arg Lys Arg Leu Gly Asp Asp Asn Leu
    50                  55                  60
Cys Asn Thr Pro His Leu Pro Pro Cys Ser Pro Pro Lys Gln Gly Lys
65                  70                  75                  80
Lys Glu Asn Gly Pro Pro His Ser His Thr Leu Lys Gly Arg Arg Leu
                85                  90                  95
Val Phe Asp Asn Gln Leu Thr Ile Lys Ser Pro Ser Lys Arg Glu Leu
            100                 105                 110
Ala Lys Val His Gln Asn Lys Ile Leu Ser Ser Val Arg Lys Ser Gln
        115                 120                 125
Glu Ile Thr Thr Asn Ser Glu Gln Arg Cys Pro Leu Lys Lys Glu Ser
    130                 135                 140
Ala Cys Val Arg Leu Phe Lys Gln Glu Gly Thr Cys Tyr Gln Gln Ala
145                 150                 155                 160
Lys Leu Val Leu Asn Thr Ala Val Pro Asp Arg Leu Pro Ala Arg Glu
                165                 170                 175
Arg Glu Met Asp Val Ile Arg Asn Phe Leu Arg Glu His Ile Cys Gly
            180                 185                 190
Lys Lys Ala Gly Ser Leu Tyr Leu Ser Gly Ala Pro Gly Thr Gly Lys
        195                 200                 205
Thr Ala Cys Leu Ser Arg Ile Leu Gln Asp Leu Lys Lys Glu Leu Lys
    210                 215                 220
Gly Phe Lys Thr Ile Met Leu Asn Cys Met Ser Leu Arg Thr Ala Gln
225                 230                 235                 240
Ala Val Phe Pro Ala Ile Ala Gln Glu Ile Cys Gln Glu Glu Val Ser
                245                 250                 255
Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His Met Thr
            260                 265                 270
Ala Glu Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met Asp Gln
        275                 280                 285
Leu Asp Ser Lys Gly Gln Asp Val Leu Tyr Thr Leu Phe Glu Trp Pro
    290                 295                 300
Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn Thr Leu
305                 310                 315                 320
Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu Lys Cys
                325                 330                 335
Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln Ile Val
            340                 345                 350
Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln Val Leu
        355                 360                 365
Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala Val Ser
    370                 375                 380
Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile Glu Ile
385                 390                 395                 400
Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu Ser Glu
                405                 410                 415
Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly Leu Ile
            420                 425                 430
His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met Thr Leu
        435                 440                 445
Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys Ile Leu
    450                 455                 460
Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys Glu Val
465                 470                 475                 480
Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg Lys Gln
                485                 490                 495
Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser Gly Leu
            500                 505                 510
Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu Thr Arg
        515                 520                 525
Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu His Ala
    530                 535                 540
Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly Leu Pro
545                 550                 555                 560

<210> 410
<211> 560
<212> PRT
<213> Homo sapiens

<400> 410
Met Pro Gln Thr Arg Ser Gln Ala Gln Ala Thr Ile Ser Phe Pro Lys
 1               5                  10                  15
Arg Lys Leu Ser Arg Ala Leu Asn Lys Ala Lys Asn Ser Ser Asp Ala
            20                  25                  30
Lys Leu Glu Pro Thr Asn Val Gln Thr Val Thr Cys Ser Pro Arg Val
        35                  40                  45
Lys Ala Leu Pro Leu Ser Pro Arg Lys Arg Leu Gly Asp Asp Asn Leu
    50                  55                  60
Cys Asn Thr Pro His Leu Pro Pro Cys Ser Pro Pro Lys Gln Gly Lys
65                  70                  75                  80
Lys Glu Asn Gly Pro Pro His Ser His Thr Leu Lys Gly Arg Arg Leu
                85                  90                  95
Val Phe Asp Asn Gln Leu Thr Ile Lys Ser Pro Ser Lys Arg Glu Leu
            100                 105                 110
Ala Lys Val His Gln Asn Lys Ile Leu Ser Ser Val Arg Lys Ser Gln
        115                 120                 125
Glu Ile Thr Thr Asn Ser Glu Gln Arg Cys Pro Leu Lys Lys Glu Ser
    130                 135                 140
Ala Cys Val Arg Leu Phe Lys Gln Glu Gly Thr Cys Tyr Gln Gln Ala
145                 150                 155                 160
Lys Leu Val Leu Asn Thr Ala Val Pro Asp Arg Leu Pro Ala Arg Glu
                165                 170                 175
Arg Glu Met Asp Val Ile Arg Asn Phe Leu Arg Glu His Ile Cys Gly
            180                 185                 190
Lys Lys Ala Gly Ser Leu Tyr Leu Ser Gly Ala Pro Gly Thr Gly Lys
        195                 200                 205
Thr Ala Cys Leu Ser Arg Ile Leu Gln Asp Leu Lys Lys Glu Leu Lys
    210                 215                 220
Gly Phe Lys Thr Ile Met Leu Asn Cys Met Ser Leu Arg Thr Ala Gln
225                 230                 235                 240
Ala Val Phe Pro Ala Ile Ala Gln Glu Ile Cys Gln Glu Glu Val Ser
                245                 250                 255
Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His Met Thr
            260                 265                 270
Ala Glu Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met Asp Gln
        275                 280                 285
Leu Asp Ser Lys Gly Gln Asp Val Leu Tyr Thr Leu Phe Glu Trp Pro
    290                 295                 300
Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn Thr Leu
305                 310                 315                 320
Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu Lys Cys
                325                 330                 335
Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln Ile Val
            340                 345                 350
Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln Val Leu
        355                 360                 365
Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala Val Ser
    370                 375                 380
Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile Glu Ile
385                 390                 395                 400
Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu Ser Glu
                405                 410                 415
Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly Leu Ile
            420                 425                 430
His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met Thr Leu
        435                 440                 445
Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys Ile Leu
    450                 455                 460
Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys Glu Val
465                 470                 475                 480
Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg Lys Gln
                485                 490                 495
Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser Gly Leu
            500                 505                 510
Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu Thr Arg
        515                 520                 525
Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu His Ala
    530                 535                 540
Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly Leu Pro
545                 550                 555                 560

<210> 411
<211> 560
<212> PRT
<213> Homo sapiens

<400> 411
Met Pro Gln Thr Arg Ser Gln Ala Gln Ala Thr Ile Ser Phe Pro Lys
 1               5                  10                  15
Arg Lys Leu Ser Arg Ala Leu Asn Lys Ala Lys Asn Ser Ser Asp Ala
            20                  25                  30
Lys Leu Glu Pro Thr Asn Val Gln Thr Val Thr Cys Ser Pro Arg Val
        35                  40                  45
Lys Ala Leu Pro Leu Ser Pro Arg Lys Arg Leu Gly Asp Asp Asn Leu
    50                  55                  60
Cys Asn Thr Pro His Leu Pro Pro Cys Ser Pro Pro Lys Gln Gly Lys
65                  70                  75                  80
Lys Glu Asn Gly Pro Pro His Ser His Thr Leu Lys Gly Arg Arg Leu
                85                  90                  95
Val Phe Asp Asn Gln Leu Thr Ile Lys Ser Pro Ser Lys Arg Glu Leu
            100                 105                 110
Ala Lys Val His Gln Asn Lys Ile Leu Ser Ser Val Arg Lys Ser Gln
        115                 120                 125
Glu Ile Thr Thr Asn Ser Glu Gln Arg Cys Pro Leu Lys Lys Glu Ser
    130                 135                 140
Ala Cys Val Arg Leu Phe Lys Gln Glu Gly Thr Cys Tyr Gln Gln Ala
145                 150                 155                 160
Lys Leu Val Leu Asn Thr Ala Val Pro Asp Arg Leu Pro Ala Arg Glu
                165                 170                 175
Arg Glu Met Asp Val Ile Arg Asn Phe Leu Arg Glu His Ile Cys Gly
            180                 185                 190
Lys Lys Ala Gly Ser Leu Tyr Leu Ser Gly Ala Pro Gly Thr Gly Lys
        195                 200                 205
Thr Ala Cys Leu Ser Arg Ile Leu Gln Asp Leu Lys Lys Glu Leu Lys
    210                 215                 220
Gly Phe Lys Thr Ile Met Leu Asn Cys Met Ser Leu Arg Thr Ala Gln
225                 230                 235                 240
Ala Val Phe Pro Ala Ile Ala Gln Glu Ile Cys Gln Glu Glu Val Ser
                245                 250                 255
Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His Met Thr
            260                 265                 270
Ala Glu Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met Asp Gln
        275                 280                 285
Leu Asp Ser Lys Gly Gln Asp Val Leu Tyr Thr Leu Phe Glu Trp Pro
    290                 295                 300
Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn Thr Leu
305                 310                 315                 320
Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu Lys Cys
                325                 330                 335
Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln Ile Val
            340                 345                 350
Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln Val Leu
        355                 360                 365
Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala Val Ser
    370                 375                 380
Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile Glu Ile
385                 390                 395                 400
Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu Ser Glu
                405                 410                 415
Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly Leu Ile
            420                 425                 430
His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met Thr Leu
        435                 440                 445
Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys Ile Leu
    450                 455                 460
Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys Glu Val
465                 470                 475                 480
Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg Lys Gln
                485                 490                 495
Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser Gly Leu
            500                 505                 510
Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu Thr Arg
        515                 520                 525
Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu His Ala
    530                 535                 540
Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly Leu Pro
545                 550                 555                 560

<210> 412
<211> 906
<212> PRT
<213> Homo sapiens

<400> 412
Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Thr Gly
 1               5                  10                  15
Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala
            20                  25                  30
Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro
        35                  40                  45
Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp
    50                  55                  60
Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser
65                  70                  75                  80
Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg
                85                  90                  95
Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn
            100                 105                 110
Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln
        115                 120                 125
Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn
    130                 135                 140
Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His
145                 150                 155                 160
Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly
                165                 170                 175
Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys
            180                 185                 190
Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala
        195                 200                 205
Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu
    210                 215                 220
Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu
225                 230                 235                 240
Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg
                245                 250                 255
Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu
            260                 265                 270
Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro
        275                 280                 285
Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala
    290                 295                 300
Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His
305                 310                 315                 320
Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe
                325                 330                 335
Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu
            340                 345                 350
Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr
        355                 360                 365
Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys
    370                 375                 380
Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met
385                 390                 395                 400
Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys
                405                 410                 415
Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp
            420                 425                 430
Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu
        435                 440                 445
Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp
    450                 455                 460
Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg
465                 470                 475                 480
Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val
                485                 490                 495
Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser
            500                 505                 510
Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His
        515                 520                 525
Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro
    530                 535                 540
Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro
545                 550                 555                 560
Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp
                565                 570                 575
Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro
            580                 585                 590
Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro
        595                 600                 605
Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu
    610                 615                 620
Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr
625                 630                 635                 640
Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly
                645                 650                 655
Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala
            660                 665                 670
Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro
        675                 680                 685
Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser
    690                 695                 700
Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys
705                 710                 715                 720
Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn
                725                 730                 735
Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu
            740                 745                 750
Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu
        755                 760                 765
Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val
    770                 775                 780
Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe
785                 790                 795                 800
Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly
                805                 810                 815
Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn
            820                 825                 830
Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala
        835                 840                 845
Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu
    850                 855                 860
Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile
865                 870                 875                 880
Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val
                885                 890                 895
Ser Ile Ser Ser Pro Ala His Val Ala Thr
            900                 905

<210> 413
<211> 982
<212> PRT
<213> Homo sapiens

<400> 413
Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn
 1               5                  10                  15
Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala
            20                  25                  30
Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys
        35                  40                  45
Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys
    50                  55                  60
Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp
65                  70                  75                  80
Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln
                85                  90                  95
Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp
            100                 105                 110
Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly
        115                 120                 125
Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr
    130                 135                 140
Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile
145                 150                 155                 160
Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala
                165                 170                 175
Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val
            180                 185                 190
Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser
        195                 200                 205
Ser Ser Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys
    210                 215                 220
Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe
225                 230                 235                 240
Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr
                245                 250                 255
His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg
            260                 265                 270
Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser
        275                 280                 285
Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly
    290                 295                 300
Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu
305                 310                 315                 320
Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser
                325                 330                 335
Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His
            340                 345                 350
Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser
        355                 360                 365
Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys
    370                 375                 380
Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp
385                 390                 395                 400
Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys
                405                 410                 415
Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly
            420                 425                 430
Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp
        435                 440                 445
Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu
    450                 455                 460
Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser
465                 470                 475                 480
Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro
                485                 490                 495
Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp
            500                 505                 510
Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly
        515                 520                 525
Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu
    530                 535                 540
Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu
545                 550                 555                 560
Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His
                565                 570                 575
His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala
            580                 585                 590
Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg
        595                 600                 605
Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn
    610                 615                 620
Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg
625                 630                 635                 640
Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser
                645                 650                 655
Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser
            660                 665                 670
Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly
        675                 680                 685
Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu
    690                 695                 700
Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn
705                 710                 715                 720
Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys
                725                 730                 735
Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu
            740                 745                 750
Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val
        755                 760                 765
Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro
    770                 775                 780
Thr Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Thr Pro Ser
785                 790                 795                 800
Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly Glu Asp Ala Phe Asp Ala
                805                 810                 815
Leu Pro Pro Ser Leu Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu
            820                 825                 830
Ile Glu His Ser Lys Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly
        835                 840                 845
Gln Asp Leu Phe Leu Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser
    850                 855                 860
Gly Gln Val Pro Leu Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val
865                 870                 875                 880
Lys Thr Asn Arg Thr Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser
                885                 890                 895
Asp Gly Ser Gln Ala Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg
            900                 905                 910
Thr Ala Pro Glu Ile His His Arg Lys Pro His Gly Pro Glu Ala Ala
        915                 920                 925
Leu Glu Asn Val Asp Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr
    930                 935                 940
Ala Phe Glu Glu Val Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val
945                 950                 955                 960
Glu Val Ala Arg Ser Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val
                965                 970                 975
Ser Pro Arg Leu Asn Leu
            980

<210> 414
<211> 810
<212> PRT
<213> Homo sapiens

<400> 414
Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn
 1               5                  10                  15
Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala
            20                  25                  30
Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys
        35                  40                  45
Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys
    50                  55                  60
Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp
65                  70                  75                  80
Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln
                85                  90                  95
Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp
            100                 105                 110
Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly
        115                 120                 125
Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr
    130                 135                 140
Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile
145                 150                 155                 160
Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala
                165                 170                 175
Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val
            180                 185                 190
Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser
        195                 200                 205
Ser Ser Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys
    210                 215                 220
Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe
225                 230                 235                 240
Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr
                245                 250                 255
His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg
            260                 265                 270
Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser
        275                 280                 285
Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly
    290                 295                 300
Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu
305                 310                 315                 320
Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser
                325                 330                 335
Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His
            340                 345                 350
Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser
        355                 360                 365
Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys
    370                 375                 380
Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp
385                 390                 395                 400
Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys
                405                 410                 415
Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly
            420                 425                 430
Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp
        435                 440                 445
Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu
    450                 455                 460
Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser
465                 470                 475                 480
Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro
                485                 490                 495
Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp
            500                 505                 510
Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly
        515                 520                 525
Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu
    530                 535                 540
Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu
545                 550                 555                 560
Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His
                565                 570                 575
His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala
            580                 585                 590
Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg
        595                 600                 605
Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn
    610                 615                 620
Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg
625                 630                 635                 640
Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser
                645                 650                 655
Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser
            660                 665                 670
Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly
        675                 680                 685
Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu
    690                 695                 700
Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn
705                 710                 715                 720
Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys
                725                 730                 735
Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu
            740                 745                 750
Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val
        755                 760                 765
Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro
    770                 775                 780
Thr Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Thr Pro Ser
785                 790                 795                 800
Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly
                805                 810

<210> 415
<211> 770
<212> PRT
<213> Homo sapiens

<400> 415
Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn
 1               5                  10                  15
Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala
            20                  25                  30
Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys
        35                  40                  45
Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys
    50                  55                  60
Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp
65                  70                  75                  80
Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln
                85                  90                  95
Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp
            100                 105                 110
Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly
        115                 120                 125
Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr
    130                 135                 140
Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile
145                 150                 155                 160
Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala
                165                 170                 175
Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val
            180                 185                 190
Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser
        195                 200                 205
Ser Ser Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys
    210                 215                 220
Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe
225                 230                 235                 240
Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr
                245                 250                 255
His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg
            260                 265                 270
Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser
        275                 280                 285
Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly
    290                 295                 300
Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu
305                 310                 315                 320
Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser
                325                 330                 335
Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His
            340                 345                 350
Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser
        355                 360                 365
Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys
    370                 375                 380
Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp
385                 390                 395                 400
Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys
                405                 410                 415
Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly
            420                 425                 430
Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp
        435                 440                 445
Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu
    450                 455                 460
Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser
465                 470                 475                 480
Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro
                485                 490                 495
Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp
            500                 505                 510
Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly
        515                 520                 525
Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu
    530                 535                 540
Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu
545                 550                 555                 560
Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His
                565                 570                 575
His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala
            580                 585                 590
Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg
        595                 600                 605
Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn
    610                 615                 620
Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg
625                 630                 635                 640
Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser
                645                 650                 655
Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser
            660                 665                 670
Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly
        675                 680                 685
Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu
    690                 695                 700
Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn
705                 710                 715                 720
Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys
                725                 730                 735
Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu
            740                 745                 750
Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Thr Tyr
        755                 760                 765
Arg Ile
    770

<210> 416
<211> 906
<212> PRT
<213> Homo sapiens

<400> 416
Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly
 1               5                  10                  15
Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala
            20                  25                  30
Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro
        35                  40                  45
Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp
    50                  55                  60
Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser
65                  70                  75                  80
Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg
                85                  90                  95
Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn
            100                 105                 110
Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln
        115                 120                 125
Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn
    130                 135                 140
Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His
145                 150                 155                 160
Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly
                165                 170                 175
Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys
            180                 185                 190
Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala
        195                 200                 205
Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu
    210                 215                 220
Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu
225                 230                 235                 240
Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg
                245                 250                 255
Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu
            260                 265                 270
Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro
        275                 280                 285
Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala
    290                 295                 300
Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His
305                 310                 315                 320
Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe
                325                 330                 335
Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu
            340                 345                 350
Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr
        355                 360                 365
Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys
    370                 375                 380
Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met
385                 390                 395                 400
Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys
                405                 410                 415
Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp
            420                 425                 430
Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu
        435                 440                 445
Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp
    450                 455                 460
Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg
465                 470                 475                 480
Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val
                485                 490                 495
Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser
            500                 505                 510
Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His
        515                 520                 525
Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro
    530                 535                 540
Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro
545                 550                 555                 560
Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp
                565                 570                 575
Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro
            580                 585                 590
Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro
        595                 600                 605
Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu
    610                 615                 620
Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr
625                 630                 635                 640
Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly
                645                 650                 655
Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala
            660                 665                 670
Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro
        675                 680                 685
Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser
    690                 695                 700
Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys
705                 710                 715                 720
Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn
                725                 730                 735
Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu
            740                 745                 750
Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu
        755                 760                 765
Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val
    770                 775                 780
Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe
785                 790                 795                 800
Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly
                805                 810                 815
Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn
            820                 825                 830
Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala
        835                 840                 845
Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu
    850                 855                 860
Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile
865                 870                 875                 880
Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val
                885                 890                 895
Ser Ile Ser Ser Pro Ala His Val Ala Thr
            900                 905

<210> 417
<211> 953
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(953)
<223> Xaa = Any Amino Acid

<400> 417
Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly
 1               5                  10                  15
Arg Gly Pro Ser Phe Thr Pro Cys Phe Ser Pro Ser Leu Ala Val Glu
            20                  25                  30
Pro Ser Arg Arg Thr Arg Leu Gly Ser Asp Pro Ala Gln Ala Met Ala
        35                  40                  45
Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly Ser Gly
    50                  55                  60
Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala Phe Gln
65                  70                  75                  80
Pro His His His His His His His Leu Ser Pro His Pro Pro Gly Thr
                85                  90                  95
Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp Lys Val
            100                 105                 110
Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser Pro Pro
        115                 120                 125
Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg Thr Ile
    130                 135                 140
Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn Glu Tyr
145                 150                 155                 160
Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln Thr Ile
                165                 170                 175
Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn Ser Gln
            180                 185                 190
Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His Met Leu
        195                 200                 205
Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly Asp Thr
    210                 215                 220
Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys Ala Phe
225                 230                 235                 240
Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala Leu His
                245                 250                 255
Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu Lys Ser
            260                 265                 270
Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp
        275                 280                 285
Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg Asn Trp
    290                 295                 300
Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu Thr Tyr
305                 310                 315                 320
Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro Gly Ser
                325                 330                 335
Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly
            340                 345                 350
Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His Asn Lys
        355                 360                 365
Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe Tyr Leu
    370                 375                 380
Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu Cys Glu
385                 390                 395                 400
Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu
                405                 410                 415
Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu
            420                 425                 430
Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met Cys Thr
        435                 440                 445
Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys Pro Phe
    450                 455                 460
Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp Pro Phe
465                 470                 475                 480
Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu Gly Ala
                485                 490                 495
Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp Asp Thr
            500                 505                 510
Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg Pro Pro
        515                 520                 525
Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val Pro Pro
    530                 535                 540
Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser Ala Ser
545                 550                 555                 560
Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His Lys Asp
                565                 570                 575
Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro Pro Pro
            580                 585                 590
Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro Gln Arg
        595                 600                 605
Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp Lys Leu
    610                 615                 620
Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro Arg Pro
625                 630                 635                 640
Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro Trp Thr
                645                 650                 655
Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu Pro Ser
            660                 665                 670
Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr Phe Ser
        675                 680                 685
Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly Pro Glu
    690                 695                 700
Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala Ile Tyr
705                 710                 715                 720
Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro Gly Glu
                725                 730                 735
Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser Ser Arg
            740                 745                 750
Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys Asp Cys
        755                 760                 765
Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn Ile Gln
    770                 775                 780
Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu Gly Asn
785                 790                 795                 800
Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu Asn Glu
                805                 810                 815
Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val Leu Ala
            820                 825                 830
Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe Gly Leu
        835                 840                 845
Phe Val Leu Glu Arg Asp Pro Xaa Pro Gln Asn Val Thr Glu Gly Ser
    850                 855                 860
Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn Ser
865                 870                 875                 880
Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala Ser
                885                 890                 895
Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu Met
            900                 905                 910
Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile Ala
        915                 920                 925
Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val Ser
    930                 935                 940
Ile Ser Ser Pro Ala His Val Ala Thr
945                 950

<210> 418
<211> 906
<212> PRT
<213> Homo sapiens

<400> 418
Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Thr Gly
 1               5                  10                  15
Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala
            20                  25                  30
Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro
        35                  40                  45
Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp
    50                  55                  60
Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser
65                  70                  75                  80
Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg
                85                  90                  95
Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn
            100                 105                 110
Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln
        115                 120                 125
Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn
    130                 135                 140
Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His
145                 150                 155                 160
Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly
                165                 170                 175
Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys
            180                 185                 190
Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala
        195                 200                 205
Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu
    210                 215                 220
Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu
225                 230                 235                 240
Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg
                245                 250                 255
Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu
            260                 265                 270
Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro
        275                 280                 285
Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala
    290                 295                 300
Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His
305                 310                 315                 320
Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe
                325                 330                 335
Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu
            340                 345                 350
Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr
        355                 360                 365
Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys
    370                 375                 380
Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met
385                 390                 395                 400
Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys
                405                 410                 415
Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp
            420                 425                 430
Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu
        435                 440                 445
Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp
    450                 455                 460
Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg
465                 470                 475                 480
Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val
                485                 490                 495
Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser
            500                 505                 510
Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His
        515                 520                 525
Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro
    530                 535                 540
Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro
545                 550                 555                 560
Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp
                565                 570                 575
Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro
            580                 585                 590
Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro
        595                 600                 605
Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu
    610                 615                 620
Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr
625                 630                 635                 640
Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly
                645                 650                 655
Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala
            660                 665                 670
Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro
        675                 680                 685
Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser
    690                 695                 700
Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys
705                 710                 715                 720
Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn
                725                 730                 735
Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu
            740                 745                 750
Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu
        755                 760                 765
Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val
    770                 775                 780
Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe
785                 790                 795                 800
Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly
                805                 810                 815
Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn
            820                 825                 830
Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala
        835                 840                 845
Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu
    850                 855                 860
Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile
865                 870                 875                 880
Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val
                885                 890                 895
Ser Ile Ser Ser Pro Ala His Val Ala Thr
            900                 905

<210> 419
<211> 770
<212> PRT
<213> Homo sapiens

<400> 419
Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn
 1               5                  10                  15
Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala
            20                  25                  30
Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys
        35                  40                  45
Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys
    50                  55                  60
Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp
65                  70                  75                  80
Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln
                85                  90                  95
Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp
            100                 105                 110
Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly
        115                 120                 125
Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr
    130                 135                 140
Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile
145                 150                 155                 160
Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala
                165                 170                 175
Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val
            180                 185                 190
Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser
        195                 200                 205
Ser Ser Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys
    210                 215                 220
Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe
225                 230                 235                 240
Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr
                245                 250                 255
His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg
            260                 265                 270
Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser
        275                 280                 285
Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly
    290                 295                 300
Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu
305                 310                 315                 320
Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser
                325                 330                 335
Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His
            340                 345                 350
Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser
        355                 360                 365
Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys
    370                 375                 380
Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp
385                 390                 395                 400
Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys
                405                 410                 415
Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly
            420                 425                 430
Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp
        435                 440                 445
Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu
    450                 455                 460
Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser
465                 470                 475                 480
Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro
                485                 490                 495
Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp
            500                 505                 510
Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly
        515                 520                 525
Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu
    530                 535                 540
Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu
545                 550                 555                 560
Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His
                565                 570                 575
His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala
            580                 585                 590
Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg
        595                 600                 605
Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn
    610                 615                 620
Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg
625                 630                 635                 640
Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser
                645                 650                 655
Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser
            660                 665                 670
Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly
        675                 680                 685
Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu
    690                 695                 700
Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn
705                 710                 715                 720
Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys
                725                 730                 735
Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu
            740                 745                 750
Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Thr Tyr
        755                 760                 765
Arg Ile
    770

<210> 420
<211> 906
<212> PRT
<213> Homo sapiens

<400> 420
Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Thr Gly
 1               5                  10                  15
Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala
            20                  25                  30
Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro
        35                  40                  45
Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp
    50                  55                  60
Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser
65                  70                  75                  80
Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg
                85                  90                  95
Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn
            100                 105                 110
Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln
        115                 120                 125
Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn
    130                 135                 140
Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His
145                 150                 155                 160
Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly
                165                 170                 175
Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys
            180                 185                 190
Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala
        195                 200                 205
Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu
    210                 215                 220
Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu
225                 230                 235                 240
Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg
                245                 250                 255
Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu
            260                 265                 270
Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro
        275                 280                 285
Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala
    290                 295                 300
Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His
305                 310                 315                 320
Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe
                325                 330                 335
Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu
            340                 345                 350
Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr
        355                 360                 365
Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys
    370                 375                 380
Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met
385                 390                 395                 400
Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys
                405                 410                 415
Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp
            420                 425                 430
Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu
        435                 440                 445
Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp
    450                 455                 460
Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg
465                 470                 475                 480
Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val
                485                 490                 495
Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser
            500                 505                 510
Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His
        515                 520                 525
Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro
    530                 535                 540
Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro
545                 550                 555                 560
Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp
                565                 570                 575
Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro
            580                 585                 590
Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro
        595                 600                 605
Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu
    610                 615                 620
Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr
625                 630                 635                 640
Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly
                645                 650                 655
Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala
            660                 665                 670
Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro
        675                 680                 685
Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser
    690                 695                 700
Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys
705                 710                 715                 720
Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn
                725                 730                 735
Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu
            740                 745                 750
Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu
        755                 760                 765
Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val
    770                 775                 780
Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe
785                 790                 795                 800
Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly
                805                 810                 815
Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn
            820                 825                 830
Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala
        835                 840                 845
Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu
    850                 855                 860
Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile
865                 870                 875                 880
Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val
                885                 890                 895
Ser Ile Ser Ser Pro Ala His Val Ala Thr
            900                 905

<210> 421
<211> 906
<212> PRT
<213> Homo sapiens

<400> 421
Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Thr Gly
 1               5                  10                  15
Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala
            20                  25                  30
Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro
        35                  40                  45
Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp
    50                  55                  60
Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser
65                  70                  75                  80
Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg
                85                  90                  95
Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn
            100                 105                 110
Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln
        115                 120                 125
Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn
    130                 135                 140
Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His
145                 150                 155                 160
Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly
                165                 170                 175
Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys
            180                 185                 190
Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala
        195                 200                 205
Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu
    210                 215                 220
Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu
225                 230                 235                 240
Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg
                245                 250                 255
Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu
            260                 265                 270
Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro
        275                 280                 285
Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala
    290                 295                 300
Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His
305                 310                 315                 320
Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe
                325                 330                 335
Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu
            340                 345                 350
Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr
        355                 360                 365
Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys
    370                 375                 380
Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met
385                 390                 395                 400
Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys
                405                 410                 415
Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp
            420                 425                 430
Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu
        435                 440                 445
Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp
    450                 455                 460
Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg
465                 470                 475                 480
Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val
                485                 490                 495
Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser
            500                 505                 510
Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His
        515                 520                 525
Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro
    530                 535                 540
Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro
545                 550                 555                 560
Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp
                565                 570                 575
Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro
            580                 585                 590
Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro
        595                 600                 605
Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu
    610                 615                 620
Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr
625                 630                 635                 640
Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly
                645                 650                 655
Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala
            660                 665                 670
Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro
        675                 680                 685
Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser
    690                 695                 700
Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys
705                 710                 715                 720
Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn
                725                 730                 735
Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu
            740                 745                 750
Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu
        755                 760                 765
Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val
    770                 775                 780
Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe
785                 790                 795                 800
Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly
                805                 810                 815
Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn
            820                 825                 830
Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala
        835                 840                 845
Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu
    850                 855                 860
Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile
865                 870                 875                 880
Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val
                885                 890                 895
Ser Ile Ser Ser Pro Ala His Val Ala Thr
            900                 905

<210> 422
<211> 982
<212> PRT
<213> Homo sapiens

<400> 422
Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn
 1               5                  10                  15
Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala
            20                  25                  30
Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys
        35                  40                  45
Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys
    50                  55                  60
Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp
65                  70                  75                  80
Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln
                85                  90                  95
Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp
            100                 105                 110
Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly
        115                 120                 125
Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr
    130                 135                 140
Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile
145                 150                 155                 160
Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala
                165                 170                 175
Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val
            180                 185                 190
Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser
        195                 200                 205
Ser Ser Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys
    210                 215                 220
Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe
225                 230                 235                 240
Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr
                245                 250                 255
His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg
            260                 265                 270
Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser
        275                 280                 285
Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly
    290                 295                 300
Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu
305                 310                 315                 320
Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser
                325                 330                 335
Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His
            340                 345                 350
Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser
        355                 360                 365
Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys
    370                 375                 380
Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp
385                 390                 395                 400
Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys
                405                 410                 415
Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly
            420                 425                 430
Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp
        435                 440                 445
Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu
    450                 455                 460
Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser
465                 470                 475                 480
Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro
                485                 490                 495
Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp
            500                 505                 510
Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly
        515                 520                 525
Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu
    530                 535                 540
Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu
545                 550                 555                 560
Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His
                565                 570                 575
His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala
            580                 585                 590
Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg
        595                 600                 605
Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn
    610                 615                 620
Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg
625                 630                 635                 640
Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser
                645                 650                 655
Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser
            660                 665                 670
Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly
        675                 680                 685
Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu
    690                 695                 700
Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn
705                 710                 715                 720
Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys
                725                 730                 735
Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu
            740                 745                 750
Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val
        755                 760                 765
Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro
    770                 775                 780
Thr Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Thr Pro Ser
785                 790                 795                 800
Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly Glu Asp Ala Phe Asp Ala
                805                 810                 815
Leu Pro Pro Ser Leu Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu
            820                 825                 830
Ile Glu His Ser Lys Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly
        835                 840                 845
Gln Asp Leu Phe Leu Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser
    850                 855                 860
Gly Gln Val Pro Leu Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val
865                 870                 875                 880
Lys Thr Asn Arg Thr Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser
                885                 890                 895
Asp Gly Ser Gln Ala Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg
            900                 905                 910
Thr Ala Pro Glu Ile His His Arg Lys Pro His Gly Pro Glu Ala Ala
        915                 920                 925
Leu Glu Asn Val Asp Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr
    930                 935                 940
Ala Phe Glu Glu Val Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val
945                 950                 955                 960
Glu Val Ala Arg Ser Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val
                965                 970                 975
Ser Pro Arg Leu Asn Leu
            980

<210> 423
<211> 979
<212> PRT
<213> Homo sapiens

<400> 423
Ala Glu Pro Ala Gly Arg Gln Arg Pro Arg Arg Glu Pro Glu Ala Met
 1               5                  10                  15
Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe Ile
            20                  25                  30
Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser Lys
        35                  40                  45
Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg Ala
    50                  55                  60
Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val Asn
65                  70                  75                  80
Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln Leu
                85                  90                  95
Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu Asn
            100                 105                 110
His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys Ile
        115                 120                 125
Cys His Gln Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr Phe
    130                 135                 140
Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val Thr Lys Val Asn Glu
145                 150                 155                 160
Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu Ile Ser Leu Val
                165                 170                 175
Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp Glu
            180                 185                 190
Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met Met Ile Ala Arg Leu
        195                 200                 205
Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu Met Gly Gln Lys Thr
    210                 215                 220
Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser Leu Leu Gln Glu Val
225                 230                 235                 240
Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu Leu Ile Ser Lys Ser
                245                 250                 255
Ser Glu Ile Leu Met Met Phe Gln Gln Val His Arg Lys Pro Met Ala
            260                 265                 270
Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu Val
        275                 280                 285
Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr Leu
    290                 295                 300
Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gln Val Ser Gly
305                 310                 315                 320
Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val Arg
                325                 330                 335
Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro Glu
            340                 345                 350
Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gln Ser Cys Asn
        355                 360                 365
Asp Pro Thr Lys Asn Ile Ile Arg Glu Phe Ala Ser Asp Phe Glu Val
    370                 375                 380
Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu Ala
385                 390                 395                 400
Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr Val Ile Leu Arg Phe
                405                 410                 415
Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser Arg Asp Gln His Trp
            420                 425                 430
Tyr Ile Thr Gln Leu Glu Ala Ala Gln Thr Ser Tyr Ile Gln Gln Ile
        435                 440                 445
Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu Ser Arg Thr Gln Lys
    450                 455                 460
Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gln Asn Asp
465                 470                 475                 480
Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met Leu
                485                 490                 495
Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu Asp
            500                 505                 510
Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp Tyr His His Glu Leu
        515                 520                 525
Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val Asn
    530                 535                 540
Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser Asn
545                 550                 555                 560
Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met Ser Gly Glu Asn Asp
                565                 570                 575
Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu Asp
            580                 585                 590
Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly Ser
        595                 600                 605
Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr Ser
    610                 615                 620
Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile His Leu Leu Asp Leu
625                 630                 635                 640
Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly Leu Gln Pro Arg Pro
                645                 650                 655
Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr Ser Arg Lys Asp Lys
            660                 665                 670
Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val Pro Ser Asp Leu Lys
        675                 680                 685
Met Leu Lys Arg Leu Lys Thr Gln Met Ala Glu Val Arg Cys Met Lys
    690                 695                 700
Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys Ser Ser Ser Ala Ala
705                 710                 715                 720
Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala Asp Gln Ala Ala Leu
                725                 730                 735
Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gln Asp Leu Gly Met
            740                 745                 750
Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr Ile Arg Asn Ser
        755                 760                 765
Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val Ala
    770                 775                 780
Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser Arg
785                 790                 795                 800
Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly Ser Pro Gly Ser Ser
                805                 810                 815
Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu Ile His Gly Ser
            820                 825                 830
Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg Gln Cys Lys Ala Leu
        835                 840                 845
Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala Val
    850                 855                 860
Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly Gly
865                 870                 875                 880
His Leu Glu Gly Leu Gln Met Thr Asp Leu Glu Asn Asn Ser Glu Thr
                885                 890                 895
Gly Glu Leu Gln Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro Glu
            900                 905                 910
Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Cys Asp Thr Glu Asn Glu
        915                 920                 925
Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe Met
    930                 935                 940
Val Met Thr Gln Pro Pro Asp Glu Asp Thr His Ser Ser Phe Pro Asp
945                 950                 955                 960
Gly Glu Gln Ile Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu Asn
                965                 970                 975
Ser Gly Arg


<210> 424
<211> 964
<212> PRT
<213> Homo sapiens

<400> 424
Met Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe
 1               5                  10                  15
Ile Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser
            20                  25                  30
Lys Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg
        35                  40                  45
Ala Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val
    50                  55                  60
Asn Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln
65                  70                  75                  80
Leu Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu
                85                  90                  95
Asn His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys
            100                 105                 110
Ile Cys His Gln Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr
        115                 120                 125
Phe Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val Thr Lys Val Asn
    130                 135                 140
Glu Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu Ile Ser Leu
145                 150                 155                 160
Val Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp
                165                 170                 175
Glu Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met Met Ile Ala Arg
            180                 185                 190
Leu Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu Met Gly Gln Lys
        195                 200                 205
Thr Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser Leu Leu Gln Glu
    210                 215                 220
Val Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu Leu Ile Ser Lys
225                 230                 235                 240
Ser Ser Glu Ile Leu Met Met Phe Gln Gln Val His Arg Lys Pro Met
                245                 250                 255
Ala Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu
            260                 265                 270
Val Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr
        275                 280                 285
Leu Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gln Val Ser
    290                 295                 300
Gly Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val
305                 310                 315                 320
Arg Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro
                325                 330                 335
Glu Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gln Ser Cys
            340                 345                 350
Asn Asp Pro Thr Lys Asn Ile Ile Arg Glu Phe Ala Ser Asp Phe Glu
        355                 360                 365
Val Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu
    370                 375                 380
Ala Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr Val Ile Leu Arg
385                 390                 395                 400
Phe Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser Arg Asp Gln His
                405                 410                 415
Trp Tyr Ile Thr Gln Leu Glu Ala Ala Gln Thr Ser Tyr Ile Gln Gln
            420                 425                 430
Ile Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu Ser Arg Thr Gln
        435                 440                 445
Lys Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gln Asn
    450                 455                 460
Asp Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met
465                 470                 475                 480
Leu Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu
                485                 490                 495
Asp Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp Tyr His His Glu
            500                 505                 510
Leu Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val
        515                 520                 525
Asn Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser
    530                 535                 540
Asn Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met Ser Gly Glu Asn
545                 550                 555                 560
Asp Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu
                565                 570                 575
Asp Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly
            580                 585                 590
Ser Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr
        595                 600                 605
Ser Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile His Leu Leu Ala
    610                 615                 620
Leu Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly Leu Gln Pro Arg
625                 630                 635                 640
Pro Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr Ser Arg Lys Asp
                645                 650                 655
Lys Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val Pro Ser Asp Leu
            660                 665                 670
Lys Met Leu Lys Arg Leu Lys Thr Gln Met Ala Glu Val Arg Cys Met
        675                 680                 685
Lys Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys Ser Ser Ser Ala
    690                 695                 700
Ala Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala Asp Gln Ala Ala
705                 710                 715                 720
Leu Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gln Asp Leu Gly
                725                 730                 735
Met Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr Ile Arg Asn
            740                 745                 750
Ser Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val
        755                 760                 765
Ala Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser
    770                 775                 780
Arg Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly Ser Pro Gly Ser
785                 790                 795                 800
Ser Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu Ile His Gly
                805                 810                 815
Ser Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg Gln Cys Lys Ala
            820                 825                 830
Leu Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala
        835                 840                 845
Val Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly
    850                 855                 860
Gly His Leu Glu Gly Leu Gln Met Thr Asp Leu Glu Asn Asn Ser Glu
865                 870                 875                 880
Thr Gly Glu Leu Gln Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro
                885                 890                 895
Glu Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Cys Asp Thr Glu Asn
            900                 905                 910
Glu Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe
        915                 920                 925
Met Val Met Thr Gln Pro Pro Asp Glu Asp Thr His Ser Ser Phe Pro
    930                 935                 940
Asp Gly Glu Gln Ile Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu
945                 950                 955                 960
Asn Ser Gly Arg


<210> 425
<211> 979
<212> PRT
<213> Homo sapiens

<400> 425
Ala Glu Pro Ala Gly Arg Gln Arg Pro Arg Arg Glu Pro Glu Ala Met
 1               5                  10                  15
Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe Ile
            20                  25                  30
Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser Lys
        35                  40                  45
Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg Ala
    50                  55                  60
Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val Asn
65                  70                  75                  80
Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln Leu
                85                  90                  95
Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu Asn
            100                 105                 110
His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys Ile
        115                 120                 125
Cys His Gln Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr Phe
    130                 135                 140
Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val Thr Lys Val Asn Glu
145                 150                 155                 160
Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu Ile Ser Leu Val
                165                 170                 175
Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp Glu
            180                 185                 190
Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met Met Ile Ala Arg Leu
        195                 200                 205
Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu Met Gly Gln Lys Thr
    210                 215                 220
Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser Leu Leu Gln Glu Val
225                 230                 235                 240
Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu Leu Ile Ser Lys Ser
                245                 250                 255
Ser Glu Ile Leu Met Met Phe Gln Gln Val His Arg Lys Pro Met Ala
            260                 265                 270
Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu Val
        275                 280                 285
Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr Leu
    290                 295                 300
Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gln Val Ser Gly
305                 310                 315                 320
Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val Arg
                325                 330                 335
Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro Glu
            340                 345                 350
Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gln Ser Cys Asn
        355                 360                 365
Asp Pro Thr Lys Asn Ile Ile Arg Glu Phe Ala Ser Asp Phe Glu Val
    370                 375                 380
Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu Ala
385                 390                 395                 400
Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr Val Ile Leu Arg Phe
                405                 410                 415
Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser Arg Asp Gln His Trp
            420                 425                 430
Tyr Ile Thr Gln Leu Glu Ala Ala Gln Thr Ser Tyr Ile Gln Gln Ile
        435                 440                 445
Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu Ser Arg Thr Gln Lys
    450                 455                 460
Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gln Asn Asp
465                 470                 475                 480
Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met Leu
                485                 490                 495
Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu Asp
            500                 505                 510
Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp Tyr His His Glu Leu
        515                 520                 525
Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val Asn
    530                 535                 540
Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser Asn
545                 550                 555                 560
Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met Ser Gly Glu Asn Asp
                565                 570                 575
Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu Asp
            580                 585                 590
Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly Ser
        595                 600                 605
Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr Ser
    610                 615                 620
Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile His Leu Leu Asp Leu
625                 630                 635                 640
Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly Leu Gln Pro Arg Pro
                645                 650                 655
Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr Ser Arg Lys Asp Lys
            660                 665                 670
Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val Pro Ser Asp Leu Lys
        675                 680                 685
Met Leu Lys Arg Leu Lys Thr Gln Met Ala Glu Val Arg Cys Met Lys
    690                 695                 700
Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys Ser Ser Ser Ala Ala
705                 710                 715                 720
Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala Asp Gln Ala Ala Leu
                725                 730                 735
Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gln Asp Leu Gly Met
            740                 745                 750
Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr Ile Arg Asn Ser
        755                 760                 765
Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val Ala
    770                 775                 780
Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser Arg
785                 790                 795                 800
Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly Ser Pro Gly Ser Ser
                805                 810                 815
Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu Ile His Gly Ser
            820                 825                 830
Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg Gln Cys Lys Ala Leu
        835                 840                 845
Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala Val
    850                 855                 860
Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly Gly
865                 870                 875                 880
His Leu Glu Gly Leu Gln Met Thr Asp Leu Glu Asn Asn Ser Glu Thr
                885                 890                 895
Gly Glu Leu Gln Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro Glu
            900                 905                 910
Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Cys Asp Thr Glu Asn Glu
        915                 920                 925
Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe Met
    930                 935                 940
Val Met Thr Gln Pro Pro Asp Glu Asp Thr His Ser Ser Phe Pro Asp
945                 950                 955                 960
Gly Glu Gln Ile Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu Asn
                965                 970                 975
Ser Gly Arg


<210> 426
<211> 979
<212> PRT
<213> Homo sapiens

<400> 426
Ala Glu Pro Ala Gly Arg Gln Arg Pro Arg Arg Glu Pro Glu Ala Met
 1               5                  10                  15
Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe Ile
            20                  25                  30
Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser Lys
        35                  40                  45
Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg Ala
    50                  55                  60
Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val Asn
65                  70                  75                  80
Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln Leu
                85                  90                  95
Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu Asn
            100                 105                 110
His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys Ile
        115                 120                 125
Cys His Gln Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr Phe
    130                 135                 140
Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val Thr Lys Val Asn Glu
145                 150                 155                 160
Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu Ile Ser Leu Val
                165                 170                 175
Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp Glu
            180                 185                 190
Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met Met Ile Ala Arg Leu
        195                 200                 205
Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu Met Gly Gln Lys Thr
    210                 215                 220
Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser Leu Leu Gln Glu Val
225                 230                 235                 240
Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu Leu Ile Ser Lys Ser
                245                 250                 255
Ser Glu Ile Leu Met Met Phe Gln Gln Val His Arg Lys Pro Met Ala
            260                 265                 270
Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu Val
        275                 280                 285
Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr Leu
    290                 295                 300
Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gln Val Ser Gly
305                 310                 315                 320
Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val Arg
                325                 330                 335
Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro Glu
            340                 345                 350
Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gln Ser Cys Asn
        355                 360                 365
Asp Pro Thr Lys Asn Ile Ile Arg Glu Phe Ala Ser Asp Phe Glu Val
    370                 375                 380
Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu Ala
385                 390                 395                 400
Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr Val Ile Leu Arg Phe
                405                 410                 415
Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser Arg Asp Gln His Trp
            420                 425                 430
Tyr Ile Thr Gln Leu Glu Ala Ala Gln Thr Ser Tyr Ile Gln Gln Ile
        435                 440                 445
Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu Ser Arg Thr Gln Lys
    450                 455                 460
Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gln Asn Asp
465                 470                 475                 480
Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met Leu
                485                 490                 495
Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu Asp
            500                 505                 510
Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp Tyr His His Glu Leu
        515                 520                 525
Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val Asn
    530                 535                 540
Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser Asn
545                 550                 555                 560
Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met Ser Gly Glu Asn Asp
                565                 570                 575
Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu Asp
            580                 585                 590
Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly Ser
        595                 600                 605
Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr Ser
    610                 615                 620
Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile His Leu Leu Asp Leu
625                 630                 635                 640
Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly Leu Gln Pro Arg Pro
                645                 650                 655
Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr Ser Arg Lys Asp Lys
            660                 665                 670
Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val Pro Ser Asp Leu Lys
        675                 680                 685
Met Leu Lys Arg Leu Lys Thr Gln Met Ala Gly Val Arg Cys Met Lys
    690                 695                 700
Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys Ser Ser Ser Ala Ala
705                 710                 715                 720
Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala Asp Gln Ala Ala Leu
                725                 730                 735
Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gln Asp Leu Gly Met
            740                 745                 750
Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr Ile Arg Asn Ser
        755                 760                 765
Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val Ala
    770                 775                 780
Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser Arg
785                 790                 795                 800
Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly Ser Pro Gly Ser Ser
                805                 810                 815
Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu Ile His Gly Ser
            820                 825                 830
Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg Gln Cys Lys Ala Leu
        835                 840                 845
Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala Val
    850                 855                 860
Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly Gly
865                 870                 875                 880
His Leu Glu Gly Leu Gln Met Thr Asp Leu Glu Asn Asn Ser Glu Thr
                885                 890                 895
Gly Glu Leu Gln Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro Glu
            900                 905                 910
Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Cys Asp Thr Glu Asn Glu
        915                 920                 925
Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe Met
    930                 935                 940
Val Met Thr Gln Pro Pro Asp Glu Asp Thr His Ser Ser Phe Pro Asp
945                 950                 955                 960
Gly Glu Gln Ile Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu Asn
                965                 970                 975
Ser Gly Arg


<210> 427
<211> 979
<212> PRT
<213> Homo sapiens

<400> 427
Ala Glu Pro Ala Gly Arg Gln Arg Pro Arg Arg Glu Pro Glu Ala Met
 1               5                  10                  15
Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe Ile
            20                  25                  30
Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser Lys
        35                  40                  45
Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg Ala
    50                  55                  60
Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val Asn
65                  70                  75                  80
Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln Leu
                85                  90                  95
Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu Asn
            100                 105                 110
His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys Ile
        115                 120                 125
Cys His Gln Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr Phe
    130                 135                 140
Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val Thr Lys Val Asn Glu
145                 150                 155                 160
Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu Ile Ser Leu Val
                165                 170                 175
Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp Glu
            180                 185                 190
Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met Met Ile Ala Arg Leu
        195                 200                 205
Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu Met Gly Gln Lys Thr
    210                 215                 220
Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser Leu Leu Gln Glu Val
225                 230                 235                 240
Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu Leu Ile Ser Lys Ser
                245                 250                 255
Ser Glu Ile Leu Met Met Phe Gln Gln Val His Arg Lys Pro Met Ala
            260                 265                 270
Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu Val
        275                 280                 285
Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr Leu
    290                 295                 300
Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gln Val Ser Gly
305                 310                 315                 320
Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val Arg
                325                 330                 335
Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro Glu
            340                 345                 350
Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gln Ser Cys Asn
        355                 360                 365
Asp Pro Thr Lys Asn Ile Ile Arg Glu Phe Ala Ser Asp Phe Glu Val
    370                 375                 380
Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu Ala
385                 390                 395                 400
Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr Val Ile Leu Arg Phe
                405                 410                 415
Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser Arg Asp Gln His Trp
            420                 425                 430
Tyr Ile Thr Gln Leu Glu Ala Ala Gln Thr Ser Tyr Ile Gln Gln Ile
        435                 440                 445
Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu Ser Arg Thr Gln Lys
    450                 455                 460
Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gln Asn Asp
465                 470                 475                 480
Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met Leu
                485                 490                 495
Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu Asp
            500                 505                 510
Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp Tyr His His Glu Leu
        515                 520                 525
Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val Asn
    530                 535                 540
Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser Asn
545                 550                 555                 560
Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met Ser Gly Glu Asn Asp
                565                 570                 575
Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu Asp
            580                 585                 590
Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly Ser
        595                 600                 605
Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr Ser
    610                 615                 620
Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile His Leu Leu Asp Leu
625                 630                 635                 640
Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly Leu Gln Pro Arg Pro
                645                 650                 655
Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr Ser Arg Lys Asp Lys
            660                 665                 670
Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val Pro Ser Asp Leu Lys
        675                 680                 685
Met Leu Lys Arg Leu Lys Thr Gln Met Ala Glu Val Arg Cys Met Lys
    690                 695                 700
Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys Ser Ser Ser Ala Ala
705                 710                 715                 720
Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala Asp Gln Ala Ala Leu
                725                 730                 735
Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gln Asp Leu Gly Met
            740                 745                 750
Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr Ile Arg Asn Ser
        755                 760                 765
Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val Ala
    770                 775                 780
Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser Arg
785                 790                 795                 800
Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly Ser Pro Gly Ser Ser
                805                 810                 815
Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu Ile His Gly Ser
            820                 825                 830
Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg Gln Cys Lys Ala Leu
        835                 840                 845
Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala Val
    850                 855                 860
Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly Gly
865                 870                 875                 880
His Leu Glu Gly Leu Gln Met Thr Asp Leu Glu Asn Asn Ser Glu Thr
                885                 890                 895
Gly Glu Leu Gln Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro Glu
            900                 905                 910
Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Cys Asp Thr Glu Asn Glu
        915                 920                 925
Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe Met
    930                 935                 940
Val Met Thr Gln Pro Pro Asp Glu Asp Thr His Ser Ser Phe Pro Asp
945                 950                 955                 960
Gly Glu Gln Ile Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu Asn
                965                 970                 975
Ser Gly Arg


<210> 428
<211> 964
<212> PRT
<213> Homo sapiens

<400> 428
Met Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe
 1               5                  10                  15
Ile Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser
            20                  25                  30
Lys Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg
        35                  40                  45
Ala Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val
    50                  55                  60
Asn Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln
65                  70                  75                  80
Leu Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu
                85                  90                  95
Asn His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys
            100                 105                 110
Ile Cys His Gln Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr
        115                 120                 125
Phe Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val Thr Lys Val Asn
    130                 135                 140
Glu Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu Ile Ser Leu
145                 150                 155                 160
Val Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp
                165                 170                 175
Glu Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met Met Ile Ala Arg
            180                 185                 190
Leu Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu Met Gly Gln Lys
        195                 200                 205
Thr Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser Leu Leu Gln Glu
    210                 215                 220
Val Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu Leu Ile Ser Lys
225                 230                 235                 240
Ser Ser Glu Ile Leu Met Met Phe Gln Gln Val His Arg Lys Pro Met
                245                 250                 255
Ala Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu
            260                 265                 270
Val Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr
        275                 280                 285
Leu Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gln Val Ser
    290                 295                 300
Gly Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val
305                 310                 315                 320
Arg Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro
                325                 330                 335
Glu Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gln Ser Cys
            340                 345                 350
Asn Asp Pro Thr Lys Asn Ile Ile Arg Cys Phe Ala Ser Asp Phe Glu
        355                 360                 365
Val Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu
    370                 375                 380
Ala Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr Val Ile Leu Arg
385                 390                 395                 400
Phe Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser Arg Asp Gln His
                405                 410                 415
Trp Tyr Thr Ile Gln Leu Glu Ala Ala Gln Thr Ser Tyr Ile Gln Gln
            420                 425                 430
Ile Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu Ser Arg Thr Gln
        435                 440                 445
Lys Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gln Asn
    450                 455                 460
Asp Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met
465                 470                 475                 480
Leu Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu
                485                 490                 495
Asp Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp Tyr His His Glu
            500                 505                 510
Leu Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val
        515                 520                 525
Asn Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser
    530                 535                 540
Asn Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met Ser Gly Glu Asn
545                 550                 555                 560
Asp Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu
                565                 570                 575
Asp Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly
            580                 585                 590
Ser Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr
        595                 600                 605
Ser Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile His Leu Leu Asp
    610                 615                 620
Leu Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly Leu Gln Pro Arg
625                 630                 635                 640
Pro Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr Ser Arg Lys Asp
                645                 650                 655
Lys Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val Pro Ser Asp Leu
            660                 665                 670
Lys Met Leu Lys Arg Leu Lys Thr Gln Met Ala Glu Val Arg Cys Met
        675                 680                 685
Lys Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys Ser Ser Ser Ala
    690                 695                 700
Ala Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala Asp Gln Ala Ala
705                 710                 715                 720
Leu Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gln Asp Leu Gly
                725                 730                 735
Met Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr Ile Arg Asn
            740                 745                 750
Ser Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val
        755                 760                 765
Ala Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser
    770                 775                 780
Arg Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly Ser Pro Gly Ser
785                 790                 795                 800
Ser Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu Ile His Gly
                805                 810                 815
Ser Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg Gln Cys Lys Ala
            820                 825                 830
Leu Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala
        835                 840                 845
Val Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly
    850                 855                 860
Gly His Leu Phe Gly Leu Gln Met Thr Asp Leu Glu Asn Asn Ser Glu
865                 870                 875                 880
Thr Gly Phe Leu Gln Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro
                885                 890                 895
Glu Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Gly Asp Thr Glu Asn
            900                 905                 910
Glu Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe
        915                 920                 925
Met Val Met Thr Gln Pro Pro Asp Glu Asp Thr His Ser Ser Glu Pro
    930                 935                 940
Asp Gly Phe Gln Ile Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu
945                 950                 955                 960
Asn Ser Gly Arg


<210> 429
<211> 964
<212> PRT
<213> Homo sapiens

<400> 429
Met Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe
 1               5                  10                  15
Ile Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser
            20                  25                  30
Lys Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg
        35                  40                  45
Ala Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val
    50                  55                  60
Asn Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln
65                  70                  75                  80
Leu Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu
                85                  90                  95
Asn His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys
            100                 105                 110
Ile Cys His Gln Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr
        115                 120                 125
Phe Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val Thr Lys Val Asn
    130                 135                 140
Glu Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu Ile Ser Leu
145                 150                 155                 160
Val Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp
                165                 170                 175
Glu Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met Met Ile Ala Arg
            180                 185                 190
Leu Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu Met Gly Gln Lys
        195                 200                 205
Thr Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser Leu Leu Gln Glu
    210                 215                 220
Val Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu Leu Ile Ser Lys
225                 230                 235                 240
Ser Ser Glu Ile Leu Met Met Phe Gln Gln Val His Arg Lys Pro Met
                245                 250                 255
Ala Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu
            260                 265                 270
Val Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr
        275                 280                 285
Leu Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gln Val Ser
    290                 295                 300
Gly Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val
305                 310                 315                 320
Arg Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro
                325                 330                 335
Glu Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gln Ser Cys
            340                 345                 350
Asn Asp Pro Thr Lys Asn Ile Ile Arg Glu Phe Ala Ser Asp Phe Glu
        355                 360                 365
Val Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu
    370                 375                 380
Ala Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr Val Ile Leu Arg
385                 390                 395                 400
Phe Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser Arg Asp Gln His
                405                 410                 415
Trp Tyr Ile Thr Gln Leu Glu Ala Ala Gln Thr Ser Tyr Ile Gln Gln
            420                 425                 430
Ile Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu Ser Arg Thr Gln
        435                 440                 445
Lys Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gln Asn
    450                 455                 460
Asp Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met
465                 470                 475                 480
Leu Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu
                485                 490                 495
Asp Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp Tyr His His Glu
            500                 505                 510
Leu Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val
        515                 520                 525
Asn Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser
    530                 535                 540
Asn Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met Ser Gly Glu Asn
545                 550                 555                 560
Asp Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu
                565                 570                 575
Asp Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly
            580                 585                 590
Ser Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr
        595                 600                 605
Ser Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile His Leu Leu Asp
    610                 615                 620
Leu Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly Leu Gln Pro Arg
625                 630                 635                 640
Pro Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr Ser Arg Lys Asp
                645                 650                 655
Lys Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val Pro Ser Asp Leu
            660                 665                 670
Lys Met Leu Lys Arg Leu Lys Thr Gln Met Ala Glu Val Arg Cys Met
        675                 680                 685
Lys Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys Ser Ser Ser Ala
    690                 695                 700
Ala Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala Asp Gln Ala Ala
705                 710                 715                 720
Leu Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gln Asp Leu Gly
                725                 730                 735
Met Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr Ile Arg Asn
            740                 745                 750
Ser Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val
        755                 760                 765
Ala Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser
    770                 775                 780
Arg Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly Ser Pro Gly Ser
785                 790                 795                 800
Ser Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu Ile His Gly
                805                 810                 815
Ser Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg Gln Cys Lys Ala
            820                 825                 830
Leu Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala
        835                 840                 845
Val Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly
    850                 855                 860
Gly His Leu Glu Gly Leu Gln Met Thr Asp Leu Glu Asn Asn Ser Glu
865                 870                 875                 880
Thr Gly Glu Leu Gln Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro
                885                 890                 895
Glu Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Cys Asp Thr Glu Asn
            900                 905                 910
Glu Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe
        915                 920                 925
Met Val Met Thr Gln Pro Pro Asp Glu Asp Thr His Ser Ser Phe Pro
    930                 935                 940
Asp Gly Glu Gln Ile Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu
945                 950                 955                 960
Asn Ser Gly Arg


<210> 430
<211> 1016
<212> PRT
<213> Homo sapiens

<400> 430
Arg Asp Gly Ala Arg Arg Trp Gly Gly Cys Gln Ser Pro Leu Thr Trp
 1               5                  10                  15
Ala Pro Gly Phe Tyr Arg Arg Phe Asp Leu Ala Thr Ser Gly Arg Arg
            20                  25                  30
Leu Arg Gly Gln Thr Ala Glu Pro Ala Gly Arg Gln Arg Pro Arg Arg
        35                  40                  45
Glu Pro Glu Ala Met Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val
    50                  55                  60
Phe Arg Cys Phe Ile Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys
65                  70                  75                  80
Pro His Cys Ser Lys Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu
                85                  90                  95
Thr Glu Gln Arg Ala Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu
            100                 105                 110
Arg Glu Leu Val Asn Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu
        115                 120                 125
Asp Thr Leu Gln Leu Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys
    130                 135                 140
Asp Lys Cys Glu Asn His His Glu Lys Leu Ser Val Phe Cys Trp Thr
145                 150                 155                 160
Cys Lys Lys Cys Ile Cys His Gln Cys Ala Leu Trp Gly Gly Met His
                165                 170                 175
Gly Gly His Thr Phe Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val
            180                 185                 190
Thr Lys Val Asn Glu Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu
        195                 200                 205
Leu Ile Ser Leu Val Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg
    210                 215                 220
Asn Ala Lys Asp Glu Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met
225                 230                 235                 240
Met Ile Ala Arg Leu Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu
                245                 250                 255
Met Gly Gln Lys Thr Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser
            260                 265                 270
Leu Leu Gln Glu Val Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu
        275                 280                 285
Leu Ile Ser Lys Ser Ser Glu Ile Leu Met Met Phe Gln Gln Val His
    290                 295                 300
Arg Lys Pro Met Ala Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe
305                 310                 315                 320
Thr Ser Glu Leu Val Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu
                325                 330                 335
Asn Phe Ser Thr Leu Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro
            340                 345                 350
Leu Gln Val Ser Gly Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly
        355                 360                 365
Asn Gly Val Val Arg Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser
    370                 375                 380
Ala Gly Leu Pro Glu Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val
385                 390                 395                 400
His Gln Ser Cys Asn Asp Pro Thr Lys Asn Ile Ile Arg Glu Phe Ala
                405                 410                 415
Ser Asp Phe Glu Val Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg
            420                 425                 430
Leu Asp Leu Leu Ala Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr
        435                 440                 445
Val Ile Leu Arg Phe Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser
    450                 455                 460
Arg Asp Gln His Trp Tyr Ile Thr Gln Leu Glu Ala Ala Gln Thr Ser
465                 470                 475                 480
Tyr Ile Gln Gln Ile Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu
                485                 490                 495
Ser Arg Thr Gln Lys Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu
            500                 505                 510
Ser Pro Gln Asn Asp Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala
        515                 520                 525
Cys Ser Asp Met Leu Leu Glu Arg Gly Pro Tyr Ser Ala Ser Val Arg
    530                 535                 540
Glu Ala Lys Glu Asp Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp
545                 550                 555                 560
Tyr His His Glu Leu Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr
                565                 570                 575
Glu Asp Glu Val Asn Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser
            580                 585                 590
Thr Ala Thr Ser Asn Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met
        595                 600                 605
Ser Gly Glu Asn Asp Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly
    610                 615                 620
Glu Leu Met Glu Asp Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His
625                 630                 635                 640
Gly Tyr Val Gly Ser Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys
                645                 650                 655
Ser Ala Ala Thr Ser Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile
            660                 665                 670
His Leu Leu Asp Leu Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly
        675                 680                 685
Leu Gln Pro Arg Pro Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr
    690                 695                 700
Ser Arg Lys Asp Lys Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val
705                 710                 715                 720
Pro Ser Asp Leu Lys Met Leu Lys Arg Leu Lys Thr Gln Met Ala Glu
                725                 730                 735
Val Arg Cys Met Lys Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys
            740                 745                 750
Ser Ser Ser Ala Ala Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala
        755                 760                 765
Asp Gln Ala Ala Leu Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu
    770                 775                 780
Gln Asp Leu Gly Met Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys
785                 790                 795                 800
Tyr Ile Arg Asn Ser Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala
                805                 810                 815
Arg Ser Ser Val Ala Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro
            820                 825                 830
Gly Glu Asn Ser Arg Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly
        835                 840                 845
Ser Pro Gly Ser Ser Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala
    850                 855                 860
Leu Ile His Gly Ser Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg
865                 870                 875                 880
Gln Cys Lys Ala Leu Asp Ser Asp Ala Val Val Val Ala Val Phe Ser
                885                 890                 895
Gly Leu Pro Ala Val Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala
            900                 905                 910
Asn Ala Lys Gly Gly His Leu Glu Gly Leu Gln Met Thr Asp Leu Glu
        915                 920                 925
Asn Asn Ser Glu Thr Gly Glu Leu Gln Pro Val Leu Pro Glu Gly Ala
    930                 935                 940
Ser Ala Ala Pro Glu Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Cys
945                 950                 955                 960
Asp Thr Glu Asn Glu Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe
                965                 970                 975
His Asp Ser Phe Met Val Met Thr Gln Pro Pro Asp Glu Asp Thr His
            980                 985                 990
Ser Ser Phe Pro Asp Gly Glu Gln Ile Gly Pro Glu Asp Leu Ser Phe
        995                 1000                1005
Asn Thr Asp Glu Asn Ser Gly Arg
    1010                1015

<210> 431
<211> 964
<212> PRT
<213> Homo sapiens

<400> 431
Met Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe
 1               5                  10                  15
Ile Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser
            20                  25                  30
Lys Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg
        35                  40                  45
Ala Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val
    50                  55                  60
Asn Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln
65                  70                  75                  80
Leu Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu
                85                  90                  95
Asn His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys
            100                 105                 110
Ile Cys His Gln Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr
        115                 120                 125
Phe Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val Thr Lys Val Asn
    130                 135                 140
Glu Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu Ile Ser Leu
145                 150                 155                 160
Val Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp
                165                 170                 175
Glu Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met Met Ile Ala Arg
            180                 185                 190
Leu Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu Met Gly Gln Lys
        195                 200                 205
Thr Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser Leu Leu Gln Glu
    210                 215                 220
Val Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu Leu Ile Ser Lys
225                 230                 235                 240
Ser Ser Glu Ile Leu Met Met Phe Gln Gln Val His Arg Lys Pro Met
                245                 250                 255
Ala Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu
            260                 265                 270
Val Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr
        275                 280                 285
Leu Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gln Val Ser
    290                 295                 300
Gly Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val
305                 310                 315                 320
Arg Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro
                325                 330                 335
Glu Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gln Ser Cys
            340                 345                 350
Asn Asp Pro Thr Lys Asn Ile Ile Arg Glu Phe Ala Ser Asp Phe Glu
        355                 360                 365
Val Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu
    370                 375                 380
Ala Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr Val Ile Leu Arg
385                 390                 395                 400
Phe Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser Arg Asp Gln His
                405                 410                 415
Trp Tyr Ile Thr Gln Leu Glu Ala Ala Gln Thr Ser Tyr Ile Gln Gln
            420                 425                 430
Ile Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu Ser Arg Thr Gln
        435                 440                 445
Lys Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gln Asn
    450                 455                 460
Asp Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met
465                 470                 475                 480
Leu Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu
                485                 490                 495
Asp Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp Tyr His His Glu
            500                 505                 510
Leu Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val
        515                 520                 525
Asn Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser
    530                 535                 540
Asn Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met Ser Gly Glu Asn
545                 550                 555                 560
Asp Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu
                565                 570                 575
Asp Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly
            580                 585                 590
Ser Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr
        595                 600                 605
Ser Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile His Leu Leu Asp
    610                 615                 620
Leu Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly Leu Gln Pro Arg
625                 630                 635                 640
Pro Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr Ser Arg Lys Asp
                645                 650                 655
Lys Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val Pro Ser Asp Leu
            660                 665                 670
Lys Met Leu Lys Arg Leu Lys Thr Gln Met Ala Glu Val Arg Cys Met
        675                 680                 685
Lys Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys Ser Ser Ser Ala
    690                 695                 700
Ala Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala Asp Gln Ala Ala
705                 710                 715                 720
Leu Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gln Asp Leu Gly
                725                 730                 735
Met Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr Ile Arg Asn
            740                 745                 750
Ser Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val
        755                 760                 765
Ala Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser
    770                 775                 780
Arg Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly Ser Pro Gly Ser
785                 790                 795                 800
Ser Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu Ile His Gly
                805                 810                 815
Ser Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg Gln Cys Lys Ala
            820                 825                 830
Leu Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala
        835                 840                 845
Val Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly
    850                 855                 860
Gly His Leu Glu Gly Leu Gln Met Thr Asp Leu Glu Asn Asn Ser Glu
865                 870                 875                 880
Thr Gly Glu Leu Gln Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro
                885                 890                 895
Glu Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Cys Asp Thr Glu Asn
            900                 905                 910
Glu Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe
        915                 920                 925
Met Val Met Thr Gln Pro Pro Asp Glu Asp Thr His Ser Ser Phe Pro
    930                 935                 940
Asp Gly Glu Gln Ile Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu
945                 950                 955                 960
Asn Ser Gly Arg


<210> 432
<211> 979
<212> PRT
<213> Homo sapiens

<400> 432
Ala Glu Pro Ala Gly Arg Gln Arg Pro Arg Arg Glu Pro Glu Ala Met
 1               5                  10                  15
Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe Ile
            20                  25                  30
Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser Lys
        35                  40                  45
Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg Ala
    50                  55                  60
Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val Asn
65                  70                  75                  80
Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln Leu
                85                  90                  95
Cys Ser Leu Thr Lys His Glu Glu Asn Glu Lys Asp Lys Cys Glu Asn
            100                 105                 110
His His Glu Lys Leu Ser Val Phe Cys Trp Thr Cys Lys Lys Cys Ile
        115                 120                 125
Cys His Gln Cys Ala Leu Trp Gly Gly Met His Gly Gly His Thr Phe
    130                 135                 140
Lys Pro Leu Ala Glu Ile Tyr Glu Gln His Val Thr Lys Val Asn Glu
145                 150                 155                 160
Glu Val Ala Lys Leu Arg Arg Arg Leu Met Glu Leu Ile Ser Leu Val
                165                 170                 175
Gln Glu Val Glu Arg Asn Val Glu Ala Val Arg Asn Ala Lys Asp Glu
            180                 185                 190
Arg Val Arg Glu Ile Arg Asn Ala Val Glu Met Met Ile Ala Arg Leu
        195                 200                 205
Asp Thr Gln Leu Lys Asn Lys Leu Ile Thr Leu Met Gly Gln Lys Thr
    210                 215                 220
Ser Leu Thr Gln Glu Thr Glu Leu Leu Glu Ser Leu Leu Gln Glu Val
225                 230                 235                 240
Glu His Gln Leu Arg Ser Cys Ser Lys Ser Glu Leu Ile Ser Lys Ser
                245                 250                 255
Ser Glu Ile Leu Met Met Phe Gln Gln Val His Arg Lys Pro Met Ala
            260                 265                 270
Ser Phe Val Thr Thr Pro Val Pro Pro Asp Phe Thr Ser Glu Leu Val
        275                 280                 285
Pro Ser Tyr Asp Ser Ala Thr Phe Val Leu Glu Asn Phe Ser Thr Leu
    290                 295                 300
Arg Gln Arg Ala Asp Pro Val Tyr Ser Pro Pro Leu Gln Val Ser Gly
305                 310                 315                 320
Leu Cys Trp Arg Leu Lys Val Tyr Pro Asp Gly Asn Gly Val Val Arg
                325                 330                 335
Gly Tyr Tyr Leu Ser Val Phe Leu Glu Leu Ser Ala Gly Leu Pro Glu
            340                 345                 350
Thr Ser Lys Tyr Glu Tyr Arg Val Glu Met Val His Gln Ser Cys Asn
        355                 360                 365
Asp Pro Thr Lys Asn Ile Ile Arg Glu Phe Ala Ser Asp Phe Glu Val
    370                 375                 380
Gly Glu Cys Trp Gly Tyr Asn Arg Phe Phe Arg Leu Asp Leu Leu Ala
385                 390                 395                 400
Asn Glu Gly Tyr Leu Asn Pro Gln Asn Asp Thr Val Ile Leu Arg Phe
                405                 410                 415
Gln Val Arg Ser Pro Thr Phe Phe Gln Lys Ser Arg Asp Gln His Trp
            420                 425                 430
Tyr Ile Thr Gln Leu Glu Ala Ala Gln Thr Ser Tyr Ile Gln Gln Ile
        435                 440                 445
Asn Asn Leu Lys Glu Arg Leu Thr Ile Glu Leu Ser Arg Thr Gln Lys
    450                 455                 460
Ser Arg Asp Leu Ser Pro Pro Asp Asn His Leu Ser Pro Gln Asn Asp
465                 470                 475                 480
Asp Ala Leu Glu Thr Arg Ala Lys Lys Ser Ala Cys Ser Asp Met Leu
                485                 490                 495
Leu Glu Gly Gly Pro Thr Thr Ala Ser Val Arg Glu Ala Lys Glu Asp
            500                 505                 510
Glu Glu Asp Glu Glu Lys Ile Gln Asn Glu Asp Tyr His His Glu Leu
        515                 520                 525
Ser Asp Gly Asp Leu Asp Leu Asp Leu Val Tyr Glu Asp Glu Val Asn
    530                 535                 540
Gln Leu Asp Gly Ser Ser Ser Ser Ala Ser Ser Thr Ala Thr Ser Asn
545                 550                 555                 560
Thr Glu Glu Asn Asp Ile Asp Glu Glu Thr Met Ser Gly Glu Asn Asp
                565                 570                 575
Val Glu Tyr Asn Asn Met Glu Leu Glu Glu Gly Glu Leu Met Glu Asp
            580                 585                 590
Ala Ala Ala Ala Gly Pro Ala Gly Ser Ser His Gly Tyr Val Gly Ser
        595                 600                 605
Ser Ser Arg Ile Ser Arg Arg Thr His Leu Cys Ser Ala Ala Thr Ser
    610                 615                 620
Ser Leu Leu Asp Ile Asp Pro Leu Ile Leu Ile His Leu Leu Asp Leu
625                 630                 635                 640
Lys Asp Arg Ser Ser Ile Glu Asn Leu Trp Gly Leu Gln Pro Arg Pro
                645                 650                 655
Pro Ala Ser Leu Leu Gln Pro Thr Ala Ser Tyr Ser Arg Lys Asp Lys
            660                 665                 670
Asp Gln Arg Lys Gln Gln Ala Met Trp Arg Val Pro Ser Asp Leu Lys
        675                 680                 685
Met Leu Lys Arg Leu Lys Thr Gln Met Ala Glu Val Arg Cys Met Lys
    690                 695                 700
Thr Asp Val Lys Asn Thr Leu Ser Glu Ile Lys Ser Ser Ser Ala Ala
705                 710                 715                 720
Ser Gly Asp Met Gln Thr Ser Leu Phe Ser Ala Asp Gln Ala Ala Leu
                725                 730                 735
Ala Ala Cys Gly Thr Glu Asn Ser Gly Arg Leu Gln Asp Leu Gly Met
            740                 745                 750
Glu Leu Leu Ala Lys Ser Ser Val Ala Asn Cys Tyr Ile Arg Asn Ser
        755                 760                 765
Thr Asn Lys Lys Ser Asn Ser Pro Lys Pro Ala Arg Ser Ser Val Ala
    770                 775                 780
Gly Ser Leu Ser Leu Arg Arg Ala Val Asp Pro Gly Glu Asn Ser Arg
785                 790                 795                 800
Ser Lys Gly Asp Cys Gln Thr Leu Ser Glu Gly Ser Pro Gly Ser Ser
                805                 810                 815
Gln Ser Gly Ser Arg His Ser Ser Pro Arg Ala Leu Ile His Gly Ser
            820                 825                 830
Ile Gly Asp Ile Leu Pro Lys Thr Glu Asp Arg Gln Cys Lys Ala Leu
        835                 840                 845
Asp Ser Asp Ala Val Val Val Ala Val Phe Ser Gly Leu Pro Ala Val
    850                 855                 860
Glu Lys Arg Arg Lys Met Val Thr Leu Gly Ala Asn Ala Lys Gly Gly
865                 870                 875                 880
His Leu Glu Gly Leu Gln Met Thr Asp Leu Glu Asn Asn Ser Glu Thr
                885                 890                 895
Gly Glu Leu Gln Pro Val Leu Pro Glu Gly Ala Ser Ala Ala Pro Glu
            900                 905                 910
Glu Gly Met Ser Ser Asp Ser Asp Ile Glu Cys Asp Thr Glu Asn Glu
        915                 920                 925
Glu Gln Glu Glu His Thr Ser Val Gly Gly Phe His Asp Ser Phe Met
    930                 935                 940
Val Met Thr Gln Pro Pro Asp Glu Asp Thr His Ser Ser Phe Pro Asp
945                 950                 955                 960
Gly Glu Gln Ile Gly Pro Glu Asp Leu Ser Phe Asn Thr Asp Glu Asn
                965                 970                 975
Ser Gly Arg


<210> 433
<211> 601
<212> PRT
<213> Homo sapiens

<400> 433
Met Ala Gly Ala Ser Glu Leu Gly Thr Gly Pro Gly Ala Ala Gly Gly
 1               5                  10                  15
Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu Ile Asp Glu Leu
            20                  25                  30
Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile Lys Lys Leu Ser
        35                  40                  45
Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg Ser Glu Leu Leu
    50                  55                  60
Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu Val Leu Leu Ala
65                  70                  75                  80
Leu Ala Glu Gln Leu Gly Asn Phe Thr Gly Leu Val Gly Gly Pro Asp
                85                  90                  95
Phe Ala His Cys Leu Leu Pro Pro Leu Glu Asn Leu Ala Thr Val Glu
            100                 105                 110
Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu Arg Gln Ile Ser
        115                 120                 125
Gln Glu His Thr Pro Val Ala Leu Glu Ala Tyr Phe Val Pro Leu Val
    130                 135                 140
Lys Arg Leu Ala Ser Gly Asp Trp Phe Thr Ser Arg Thr Ser Ala Cys
145                 150                 155                 160
Gly Leu Phe Ser Val Cys Tyr Pro Arg Ala Ser Asn Ala Val Lys Ala
                165                 170                 175
Glu Thr Arg Gln Gln Phe Arg Ser Leu Cys Ser Asp Asp Thr Pro Met
            180                 185                 190
Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe Ala Lys Val Leu
        195                 200                 205
Glu Leu Asp Ser Val Lys Ser Glu Ile Val Pro Leu Phe Thr Ser Leu
    210                 215                 220
Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala Val Glu Ala Cys
225                 230                 235                 240
Val Ser Ile Ala Gln Leu Leu Ser Gln Asp Asp Leu Glu Thr Leu Val
                245                 250                 255
Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser Trp Arg Val Arg
            260                 265                 270
Tyr Met Val Ala Asp Arg Phe Ser Glu Leu Gln Lys Ala Met Gly Pro
        275                 280                 285
Lys Ile Thr Leu Asn Asp Leu Ile Pro Ala Phe Gln Asn Leu Leu Lys
    290                 295                 300
Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ala His Lys Val Lys Glu
305                 310                 315                 320
Leu Gly Glu Asn Leu Pro Ile Glu Asp Arg Glu Thr Ile Ile Met Asn
                325                 330                 335
Gln Ile Leu Pro Tyr Ile Lys Glu Leu Val Ser Asp Thr Asn Gln His
            340                 345                 350
Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu Ser Thr Ile Leu
        355                 360                 365
Gly Lys Glu Asn Thr Ile Glu His Leu Leu Pro Leu Phe Leu Ala Gln
    370                 375                 380
Leu Lys Asp Glu Cys Pro Asp Val Arg Leu Asn Ile Ile Ser Asn Leu
385                 390                 395                 400
Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu Ser Gln Ser Leu
                405                 410                 415
Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys Trp Arg Val Arg
            420                 425                 430
Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly Gln Leu Gly Val
        435                 440                 445
Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met Ala Trp Leu Val
    450                 455                 460
Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Asn Asn Leu Met Lys
465                 470                 475                 480
Leu Val Gln Lys Phe Gly Thr Glu Trp Ala Gln Asn Thr Ile Val Pro
                485                 490                 495
Lys Val Leu Val Met Ala Asn Asp Pro Asn Tyr Leu His Arg Met Thr
            500                 505                 510
Thr Leu Phe Cys Ile Asn Ala Leu Ser Glu Ala Cys Gly Gln Glu Ile
        515                 520                 525
Thr Thr Lys Gln Met Leu Pro Ile Val Leu Lys Met Ala Gly Asp Gln
    530                 535                 540
Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu Gln Lys Ile Gly
545                 550                 555                 560
Pro Ile Leu Asp Thr Asn Ala Leu Gln Gly Glu Val Lys Pro Val Leu
                565                 570                 575
Gln Lys Leu Gly Gln Asp Glu Asp Met Asp Val Lys Tyr Phe Ala Gln
            580                 585                 590
Glu Ala Ile Ser Val Leu Ala Leu Ala
        595                 600

<210> 434
<211> 589
<212> PRT
<213> Homo sapiens

<400> 434
Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu
 1               5                  10                  15
Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile
            20                  25                  30
Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg
        35                  40                  45
Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu
    50                  55                  60
Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val
65                  70                  75                  80
Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu
                85                  90                  95
Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu
            100                 105                 110
Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe
        115                 120                 125
Val Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg
    130                 135                 140
Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser
145                 150                 155                 160
Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp
                165                 170                 175
Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe
            180                 185                 190
Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met
        195                 200                 205
Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala
    210                 215                 220
Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu
225                 230                 235                 240
Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser
                245                 250                 255
Trp Arg Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys
            260                 265                 270
Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln
        275                 280                 285
Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His
    290                 295                 300
Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn
305                 310                 315                 320
Val Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp
                325                 330                 335
Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu
            340                 345                 350
Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu
        355                 360                 365
Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile
    370                 375                 380
Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu
385                 390                 395                 400
Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys
                405                 410                 415
Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly
            420                 425                 430
Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met
        435                 440                 445
Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser
    450                 455                 460
Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala
465                 470                 475                 480
Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu
                485                 490                 495
His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys
            500                 505                 510
Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met
        515                 520                 525
Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu
    530                 535                 540
Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val
545                 550                 555                 560
Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys
                565                 570                 575
Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala
            580                 585

<210> 435
<211> 589
<212> PRT
<213> Homo sapiens

<400> 435
Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu
 1               5                  10                  15
Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile
            20                  25                  30
Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg
        35                  40                  45
Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu
    50                  55                  60
Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val
65                  70                  75                  80
Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu
                85                  90                  95
Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu
            100                 105                 110
Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe
        115                 120                 125
Val Ala Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg
    130                 135                 140
Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser
145                 150                 155                 160
Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp
                165                 170                 175
Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe
            180                 185                 190
Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met
        195                 200                 205
Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala
    210                 215                 220
Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu
225                 230                 235                 240
Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser
                245                 250                 255
Trp Arg Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys
            260                 265                 270
Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln
        275                 280                 285
Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His
    290                 295                 300
Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn
305                 310                 315                 320
Val Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp
                325                 330                 335
Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu
            340                 345                 350
Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu
        355                 360                 365
Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile
    370                 375                 380
Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu
385                 390                 395                 400
Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys
                405                 410                 415
Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly
            420                 425                 430
Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met
        435                 440                 445
Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser
    450                 455                 460
Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala
465                 470                 475                 480
Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu
                485                 490                 495
His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys
            500                 505                 510
Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met
        515                 520                 525
Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu
    530                 535                 540
Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val
545                 550                 555                 560
Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys
                565                 570                 575
Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala
            580                 585

<210> 436
<211> 589
<212> PRT
<213> Homo sapiens

<400> 436
Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu
 1               5                  10                  15
Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile
            20                  25                  30
Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg
        35                  40                  45
Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu
    50                  55                  60
Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val
65                  70                  75                  80
Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu
                85                  90                  95
Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu
            100                 105                 110
Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe
        115                 120                 125
Val Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg
    130                 135                 140
Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser
145                 150                 155                 160
Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp
                165                 170                 175
Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe
            180                 185                 190
Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met
        195                 200                 205
Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala
    210                 215                 220
Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu
225                 230                 235                 240
Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser
                245                 250                 255
Trp Ala Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys
            260                 265                 270
Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln
        275                 280                 285
Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His
    290                 295                 300
Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn
305                 310                 315                 320
Val Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp
                325                 330                 335
Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu
            340                 345                 350
Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu
        355                 360                 365
Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile
    370                 375                 380
Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu
385                 390                 395                 400
Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys
                405                 410                 415
Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly
            420                 425                 430
Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met
        435                 440                 445
Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser
    450                 455                 460
Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala
465                 470                 475                 480
Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu
                485                 490                 495
His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys
            500                 505                 510
Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met
        515                 520                 525
Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu
    530                 535                 540
Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val
545                 550                 555                 560
Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys
                565                 570                 575
Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala
            580                 585

<210> 437
<211> 575
<212> PRT
<213> Homo sapiens

<400> 437
Glu Phe Arg Pro Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn
 1               5                  10                  15
Ser Ile Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg
            20                  25                  30
Thr Arg Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Val
        35                  40                  45
Asp Glu Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Asn Phe Thr Gly
    50                  55                  60
Leu Val Gly Gly Pro Asp Phe Ala His Cys Leu Leu Pro Pro Leu Glu
65                  70                  75                  80
Asn Leu Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu
                85                  90                  95
Ser Leu Arg Gln Ile Ser Gln Glu His Thr Pro Val Ala Leu Glu Ala
            100                 105                 110
Tyr Phe Val Pro Leu Val Lys Arg Leu Ala Ser Gly Asp Trp Phe Thr
        115                 120                 125
Ser Arg Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Ala
    130                 135                 140
Ser Asn Ala Val Lys Ala Glu Thr Arg Gln Gln Phe Arg Ser Leu Cys
145                 150                 155                 160
Ser Asp Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly
                165                 170                 175
Glu Phe Ala Lys Val Leu Glu Leu Asp Ser Val Lys Ser Glu Ile Val
            180                 185                 190
Pro Leu Phe Thr Ser Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu
        195                 200                 205
Leu Ala Val Glu Ala Cys Val Ser Ile Ala Gln Leu Leu Ser Gln Asp
    210                 215                 220
Asp Leu Glu Thr Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp
225                 230                 235                 240
Lys Ser Trp Arg Val Arg Tyr Met Val Ala Asp Arg Phe Ser Glu Leu
                245                 250                 255
Gln Lys Ala Met Gly Pro Lys Ile Thr Leu Asn Asp Leu Ile Pro Ala
            260                 265                 270
Phe Gln Asn Leu Leu Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala
        275                 280                 285
Ala His Lys Val Lys Glu Leu Gly Glu Asn Leu Pro Ile Glu Asp Arg
    290                 295                 300
Glu Thr Ile Ile Met Asn Gln Ile Leu Pro Tyr Ile Lys Glu Leu Val
305                 310                 315                 320
Ser Asp Thr Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met
                325                 330                 335
Gly Leu Ser Thr Ile Leu Gly Lys Glu Asn Thr Ile Glu His Leu Leu
            340                 345                 350
Pro Leu Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Asp Val Arg Leu
        355                 360                 365
Asn Ile Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg
    370                 375                 380
Arg Leu Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp
385                 390                 395                 400
Ala Lys Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu
                405                 410                 415
Ala Gly Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu
            420                 425                 430
Cys Met Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala
        435                 440                 445
Thr Asn Asn Leu Met Lys Leu Val Gln Lys Phe Gly Thr Glu Trp Ala
    450                 455                 460
Gln Asn Thr Ile Val Pro Lys Val Leu Val Met Ala Asn Asp Pro Asn
465                 470                 475                 480
Tyr Leu His Arg Met Thr Thr Leu Phe Cys Ile Asn Ala Leu Ser Glu
                485                 490                 495
Ala Cys Gly Gln Glu Ile Thr Thr Lys Gln Met Leu Pro Ile Val Leu
            500                 505                 510
Lys Met Ala Gly Asp Gln Val Ala Asn Val Arg Phe Asn Val Ala Lys
        515                 520                 525
Ser Leu Gln Lys Ile Gly Pro Ile Leu Asp Thr Asn Ala Leu Gln Gly
    530                 535                 540
Glu Val Lys Pro Val Leu Gln Lys Leu Gly Gln Asp Glu Asp Met Asp
545                 550                 555                 560
Val Lys Tyr Phe Ala Gln Glu Ala Ile Ser Val Leu Ala Leu Ala
                565                 570                 575

<210> 438
<211> 601
<212> PRT
<213> Homo sapiens

<400> 438
Met Ala Gly Ala Ser Glu Leu Gly Thr Gly Pro Gly Ala Ala Gly Gly
 1               5                  10                  15
Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu Ile Asp Glu Leu
            20                  25                  30
Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile Lys Lys Leu Ser
        35                  40                  45
Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg Ser Glu Leu Leu
    50                  55                  60
Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu Val Leu Leu Ala
65                  70                  75                  80
Leu Ala Glu Gln Leu Gly Asn Phe Thr Gly Leu Val Gly Gly Pro Asp
                85                  90                  95
Phe Ala His Cys Leu Leu Pro Pro Leu Glu Asn Leu Ala Thr Val Glu
            100                 105                 110
Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu Arg Gln Ile Ser
        115                 120                 125
Gln Glu His Thr Pro Val Ala Leu Glu Ala Tyr Phe Val Pro Leu Val
    130                 135                 140
Lys Arg Leu Ala Ser Gly Asp Trp Phe Thr Ser Arg Thr Ser Ala Cys
145                 150                 155                 160
Gly Leu Phe Ser Val Cys Tyr Pro Arg Ala Ser Asn Ala Val Lys Ala
                165                 170                 175
Glu Thr Arg Gln Gln Phe Arg Ser Leu Cys Ser Asp Asp Thr Pro Met
            180                 185                 190
Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe Ala Lys Val Leu
        195                 200                 205
Glu Leu Asp Ser Val Lys Ser Glu Ile Val Pro Leu Phe Thr Ser Leu
    210                 215                 220
Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala Val Glu Ala Cys
225                 230                 235                 240
Val Ser Ile Ala Gln Leu Leu Ser Gln Asp Asp Leu Glu Thr Leu Val
                245                 250                 255
Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser Trp Arg Val Arg
            260                 265                 270
Tyr Met Val Ala Asp Arg Phe Ser Glu Leu Gln Lys Ala Met Gly Pro
        275                 280                 285
Lys Ile Thr Leu Asn Asp Leu Ile Pro Ala Phe Gln Asn Leu Leu Lys
    290                 295                 300
Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ala His Lys Val Lys Glu
305                 310                 315                 320
Leu Gly Glu Asn Leu Pro Ile Glu Asp Arg Glu Thr Ile Ile Met Asn
                325                 330                 335
Gln Ile Leu Pro Tyr Ile Lys Glu Leu Val Ser Asp Thr Asn Gln His
            340                 345                 350
Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu Ser Thr Ile Leu
        355                 360                 365
Gly Lys Glu Asn Thr Ile Glu His Leu Leu Pro Leu Phe Leu Ala Gln
    370                 375                 380
Leu Lys Asp Glu Cys Pro Asp Val Arg Leu Asn Ile Ile Ser Asn Leu
385                 390                 395                 400
Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu Ser Gln Ser Leu
                405                 410                 415
Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys Trp Arg Val Arg
            420                 425                 430
Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly Gln Leu Gly Val
        435                 440                 445
Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met Ala Trp Leu Val
    450                 455                 460
Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Asn Asn Leu Met Lys
465                 470                 475                 480
Leu Val Gln Lys Phe Gly Thr Glu Trp Ala Gln Asn Thr Ile Val Pro
                485                 490                 495
Lys Val Leu Val Met Ala Asn Asp Pro Asn Tyr Leu His Arg Met Thr
            500                 505                 510
Thr Leu Phe Cys Ile Asn Ala Leu Ser Glu Ala Cys Gly Gln Glu Ile
        515                 520                 525
Thr Thr Lys Gln Met Leu Pro Ile Val Leu Lys Met Ala Gly Asp Gln
    530                 535                 540
Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu Gln Lys Ile Gly
545                 550                 555                 560
Pro Ile Leu Asp Thr Asn Ala Leu Gln Gly Glu Val Lys Pro Val Leu
                565                 570                 575
Gln Lys Leu Gly Gln Asp Glu Asp Met Asp Val Lys Tyr Phe Ala Gln
            580                 585                 590
Glu Ala Ile Ser Val Leu Ala Leu Ala
        595                 600

<210> 439
<211> 601
<212> PRT
<213> Homo sapiens

<400> 439
Met Ala Gly Ala Ser Glu Leu Gly Thr Gly Pro Gly Ala Ala Gly Gly
 1               5                  10                  15
Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu Ile Asp Glu Leu
            20                  25                  30
Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile Lys Lys Leu Ser
        35                  40                  45
Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg Ser Glu Leu Leu
    50                  55                  60
Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu Val Leu Leu Ala
65                  70                  75                  80
Leu Ala Glu Gln Leu Gly Asn Phe Thr Gly Leu Val Gly Gly Pro Asp
                85                  90                  95
Phe Ala His Cys Leu Leu Pro Pro Leu Glu Asn Leu Ala Thr Val Glu
            100                 105                 110
Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu Arg Gln Ile Ser
        115                 120                 125
Gln Glu His Thr Pro Val Ala Leu Glu Ala Tyr Phe Val Pro Leu Val
    130                 135                 140
Lys Arg Leu Ala Ser Gly Asp Trp Phe Thr Ser Arg Thr Ser Ala Cys
145                 150                 155                 160
Gly Leu Phe Ser Val Cys Tyr Pro Arg Ala Ser Asn Ala Val Lys Ala
                165                 170                 175
Glu Ile Arg Gln Gln Phe Arg Ser Leu Cys Ser Asp Asp Thr Pro Met
            180                 185                 190
Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe Ala Lys Val Leu
        195                 200                 205
Glu Leu Asp Ser Val Lys Ser Glu Ile Val Pro Leu Phe Thr Ser Leu
    210                 215                 220
Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala Val Glu Ala Cys
225                 230                 235                 240
Val Ser Ile Ala Gln Leu Leu Ser Gln Asp Asp Leu Glu Thr Leu Val
                245                 250                 255
Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser Trp Arg Val Arg
            260                 265                 270
Tyr Met Val Ala Asp Arg Phe Ser Glu Leu Gln Lys Ala Met Gly Pro
        275                 280                 285
Lys Ile Thr Leu Asn Asp Leu Ile Pro Ala Phe Gln Asn Leu Leu Lys
    290                 295                 300
Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ala His Lys Val Lys Glu
305                 310                 315                 320
Leu Gly Glu Asn Leu Pro Ile Glu Asp Arg Glu Thr Ile Ile Met Asn
                325                 330                 335
Gln Ile Leu Pro Tyr Ile Lys Glu Leu Val Ser Asp Thr Asn Gln His
            340                 345                 350
Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu Ser Thr Ile Leu
        355                 360                 365
Gly Lys Glu Asn Thr Ile Glu His Leu Leu Pro Leu Phe Leu Ala Gln
    370                 375                 380
Leu Lys Asp Glu Cys Pro Asp Val Arg Leu Asn Ile Ile Ser Asn Leu
385                 390                 395                 400
Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu Ser Gln Ser Leu
                405                 410                 415
Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys Trp Arg Val Arg
            420                 425                 430
Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly Gln Leu Gly Val
        435                 440                 445
Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met Ala Trp Leu Val
    450                 455                 460
Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Asn Asn Leu Met Lys
465                 470                 475                 480
Leu Val Gln Lys Phe Gly Thr Glu Trp Ala Gln Asn Thr Ile Val Pro
                485                 490                 495
Lys Val Leu Val Met Ala Asn Asp Pro Asn Tyr Leu His Arg Met Thr
            500                 505                 510
Thr Leu Phe Cys Ile Asn Ala Leu Ser Glu Ala Cys Gly Gln Glu Ile
        515                 520                 525
Thr Thr Lys Gln Met Leu Pro Ile Val Leu Lys Met Ala Gly Asp Gln
    530                 535                 540
Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu Gln Lys Ile Gly
545                 550                 555                 560
Pro Ile Leu Asp Thr Asn Ala Leu Gln Gly Glu Val Lys Pro Val Leu
                565                 570                 575
Gln Lys Leu Gly Gln Asp Glu Asp Met Asp Val Lys Tyr Phe Ala Gln
            580                 585                 590
Glu Ala Ile Ser Val Leu Ala Leu Ala
        595                 600

<210> 440
<211> 596
<212> PRT
<213> Homo sapiens

<400> 440
Gln Glu Arg Asp Gly Ala Lys Met Ala Ala Ala Asp Gly Asp Asp Ser
 1               5                  10                  15
Leu Tyr Pro Ile Ala Val Leu Ile Asp Glu Leu Arg Asn Glu Asp Val
            20                  25                  30
Gln Leu Arg Leu Asn Ser Ile Lys Lys Leu Ser Thr Ile Ala Leu Ala
        35                  40                  45
Leu Gly Val Glu Arg Thr Arg Ser Glu Leu Leu Pro Phe Leu Thr Asp
    50                  55                  60
Thr Ile Tyr Asp Glu Asp Glu Val Leu Leu Ala Leu Ala Glu Gln Leu
65                  70                  75                  80
Gly Thr Phe Thr Thr Leu Val Gly Gly Pro Glu Tyr Val His Cys Leu
                85                  90                  95
Leu Pro Pro Leu Glu Ser Leu Ala Thr Val Glu Glu Thr Val Val Arg
            100                 105                 110
Asp Lys Ala Val Glu Ser Leu Arg Ala Ile Ser His Glu His Ser Pro
        115                 120                 125
Ser Asp Leu Glu Ala His Phe Val Pro Leu Val Lys Arg Leu Ala Gly
    130                 135                 140
Gly Asp Trp Phe Thr Ser Arg Thr Ser Ala Cys Gly Leu Phe Ser Val
145                 150                 155                 160
Cys Tyr Pro Arg Val Ser Ser Ala Val Lys Ala Glu Leu Arg Gln Tyr
                165                 170                 175
Phe Arg Asn Leu Cys Ser Asp Asp Thr Pro Met Val Arg Arg Ala Ala
            180                 185                 190
Ala Ser Lys Leu Gly Glu Phe Ala Lys Val Leu Glu Leu Asp Asn Val
        195                 200                 205
Lys Ser Glu Ile Ile Pro Met Phe Ser Asn Leu Ala Ser Asp Glu Gln
    210                 215                 220
Asp Ser Val Arg Leu Leu Ala Val Glu Ala Cys Val Asn Ile Ala Gln
225                 230                 235                 240
Leu Leu Pro Gln Glu Asp Leu Glu Ala Leu Val Met Pro Thr Leu Arg
                245                 250                 255
Gln Ala Ala Glu Asp Lys Ser Trp Arg Val Arg Tyr Met Val Ala Asp
            260                 265                 270
Lys Phe Thr Glu Leu Gln Lys Ala Val Gly Pro Glu Ile Thr Lys Thr
        275                 280                 285
Asp Leu Val Pro Ala Phe Gln Asn Leu Met Lys Asp Cys Glu Ala Glu
    290                 295                 300
Val Arg Ala Ala Ala Ser His Lys Val Lys Glu Phe Cys Glu Asn Leu
305                 310                 315                 320
Ser Ala Asp Cys Arg Glu Asn Val Ile Met Ser Gln Ile Leu Pro Cys
                325                 330                 335
Ile Lys Glu Leu Val Ser Asp Ala Asn Gln His Val Lys Ser Ala Leu
            340                 345                 350
Ala Ser Val Ile Met Gly Leu Ser Pro Ile Leu Gly Lys Asp Asn Thr
        355                 360                 365
Ile Glu His Leu Leu Pro Leu Phe Leu Ala Gln Leu Lys Asp Glu Cys
    370                 375                 380
Pro Glu Val Arg Leu Asn Ile Ile Ser Asn Leu Asp Cys Val Asn Glu
385                 390                 395                 400
Val Ile Gly Ile Arg Gln Leu Ser Gln Ser Leu Leu Pro Ala Ile Val
                405                 410                 415
Glu Leu Ala Glu Asp Ala Lys Trp Arg Val Arg Leu Ala Ile Ile Glu
            420                 425                 430
Tyr Met Pro Leu Leu Ala Gly Gln Leu Gly Val Glu Phe Phe Asp Glu
        435                 440                 445
Lys Leu Asn Ser Leu Cys Met Ala Trp Leu Val Asp His Val Tyr Ala
    450                 455                 460
Ile Arg Glu Ala Ala Thr Ser Asn Leu Lys Lys Leu Val Glu Lys Phe
465                 470                 475                 480
Gly Lys Glu Trp Ala His Ala Thr Ile Ile Pro Lys Val Leu Ala Met
                485                 490                 495
Ser Gly Asp Pro Asn Tyr Leu His Arg Met Thr Thr Leu Phe Cys Ile
            500                 505                 510
Asn Val Leu Ser Glu Val Cys Gly Gln Asp Ile Thr Thr Lys His Met
        515                 520                 525
Leu Pro Thr Val Leu Arg Met Ala Gly Asp Pro Val Ala Asn Val Arg
    530                 535                 540
Phe Asn Val Ala Lys Ser Leu Gln Lys Ile Gly Pro Ile Leu Asp Asn
545                 550                 555                 560
Ser Thr Leu Gln Ser Glu Val Lys Pro Ile Leu Glu Lys Leu Thr Gln
                565                 570                 575
Asp Gln Asp Val Asp Val Lys Tyr Phe Ala Gln Glu Ala Leu Thr Val
            580                 585                 590
Leu Ser Leu Ala
        595

<210> 441
<211> 601
<212> PRT
<213> Homo sapiens

<400> 441
Met Ala Gly Ala Ser Glu Leu Gly Thr Gly Pro Gly Ala Ala Gly Gly
 1               5                  10                  15
Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu Ile Asp Glu Leu
            20                  25                  30
Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile Lys Lys Leu Ser
        35                  40                  45
Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg Ser Glu Leu Leu
    50                  55                  60
Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu Val Leu Leu Ala
65                  70                  75                  80
Leu Ala Glu Gln Leu Gly Asn Phe Thr Gly Leu Val Gly Gly Pro Asp
                85                  90                  95
Phe Ala His Cys Leu Leu Pro Pro Leu Glu Asn Leu Ala Thr Val Glu
            100                 105                 110
Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu Arg Gln Ile Ser
        115                 120                 125
Gln Glu His Thr Pro Val Ala Leu Glu Ala Tyr Phe Val Pro Leu Val
    130                 135                 140
Lys Arg Leu Ala Ser Gly Asp Trp Phe Thr Ser Arg Thr Ser Ala Cys
145                 150                 155                 160
Gly Leu Phe Ser Val Cys Tyr Pro Arg Ala Ser Asn Ala Val Lys Ala
                165                 170                 175
Glu Ile Arg Gln Gln Phe Arg Ser Leu Cys Ser Asp Asp Thr Pro Met
            180                 185                 190
Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe Ala Lys Val Leu
        195                 200                 205
Glu Leu Asp Ser Val Lys Ser Glu Ile Val Pro Leu Phe Thr Ser Leu
    210                 215                 220
Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala Val Glu Ala Cys
225                 230                 235                 240
Val Ser Ile Ala Gln Leu Leu Ser Gln Asp Asp Leu Glu Thr Leu Val
                245                 250                 255
Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser Trp Arg Val Arg
            260                 265                 270
Tyr Met Val Ala Asp Arg Phe Ser Glu Leu Gln Lys Ala Met Gly Pro
        275                 280                 285
Lys Ile Thr Leu Asn Asp Leu Ile Pro Ala Phe Gln Asn Leu Leu Lys
    290                 295                 300
Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ala His Lys Val Lys Glu
305                 310                 315                 320
Leu Gly Glu Asn Leu Pro Ile Glu Asp Arg Glu Thr Ile Ile Met Asn
                325                 330                 335
Gln Ile Leu Pro Tyr Ile Lys Glu Leu Val Ser Asp Thr Asn Gln His
            340                 345                 350
Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu Ser Thr Ile Leu
        355                 360                 365
Gly Lys Glu Asn Thr Ile Glu His Leu Leu Pro Leu Phe Leu Ala Gln
    370                 375                 380
Leu Lys Asp Glu Cys Pro Asp Val Arg Leu Asn Ile Ile Ser Asn Leu
385                 390                 395                 400
Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu Ser Gln Ser Leu
                405                 410                 415
Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys Trp Arg Val Arg
            420                 425                 430
Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly Gln Leu Gly Val
        435                 440                 445
Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met Ala Trp Leu Val
    450                 455                 460
Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Asn Asn Leu Met Lys
465                 470                 475                 480
Leu Val Gln Lys Phe Gly Thr Glu Trp Ala Gln Asn Thr Ile Val Pro
                485                 490                 495
Lys Val Leu Val Met Ala Asn Asp Pro Asn Tyr Leu His Arg Met Thr
            500                 505                 510
Thr Leu Phe Cys Ile Asn Ala Leu Ser Glu Ala Cys Gly Gln Glu Ile
        515                 520                 525
Thr Thr Lys Gln Met Leu Pro Ile Val Leu Lys Met Ala Gly Asp Gln
    530                 535                 540
Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu Gln Lys Ile Gly
545                 550                 555                 560
Pro Ile Leu Asp Thr Asn Ala Leu Gln Gly Glu Val Lys Pro Val Leu
                565                 570                 575
Gln Lys Leu Gly Gln Asp Glu Asp Met Asp Val Lys Tyr Phe Ala Gln
            580                 585                 590
Glu Ala Ile Ser Val Leu Ala Leu Ala
        595                 600

<210> 442
<211> 589
<212> PRT
<213> Homo sapiens

<400> 442
Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu
 1               5                  10                  15
Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile
            20                  25                  30
Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg
        35                  40                  45
Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu
    50                  55                  60
Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val
65                  70                  75                  80
Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu
                85                  90                  95
Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu
            100                 105                 110
Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe
        115                 120                 125
Val Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg
    130                 135                 140
Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser
145                 150                 155                 160
Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp
                165                 170                 175
Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe
            180                 185                 190
Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met
        195                 200                 205
Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala
    210                 215                 220
Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu
225                 230                 235                 240
Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser
                245                 250                 255
Trp Ala Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys
            260                 265                 270
Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln
        275                 280                 285
Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His
    290                 295                 300
Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn
305                 310                 315                 320
Val Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp
                325                 330                 335
Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu
            340                 345                 350
Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu
        355                 360                 365
Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile
    370                 375                 380
Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu
385                 390                 395                 400
Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys
                405                 410                 415
Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly
            420                 425                 430
Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met
        435                 440                 445
Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser
    450                 455                 460
Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala
465                 470                 475                 480
Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu
                485                 490                 495
His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys
            500                 505                 510
Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met
        515                 520                 525
Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu
    530                 535                 540
Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val
545                 550                 555                 560
Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys
                565                 570                 575
Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala
            580                 585

<210> 443
<211> 588
<212> PRT
<213> Homo sapiens

<400> 443
Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu Ile
 1               5                  10                  15
Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile Lys
            20                  25                  30
Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg Ser
        35                  40                  45
Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu Val
    50                  55                  60
Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val Gly
65                  70                  75                  80
Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu Ala
                85                  90                  95
Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu Arg
            100                 105                 110
Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe Val
        115                 120                 125
Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg Thr
    130                 135                 140
Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser Ala
145                 150                 155                 160
Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp Asp
                165                 170                 175
Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe Ala
            180                 185                 190
Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met Phe
        195                 200                 205
Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala Val
    210                 215                 220
Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu Glu
225                 230                 235                 240
Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser Trp
                245                 250                 255
Ala Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys Ala
            260                 265                 270
Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln Asn
        275                 280                 285
Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His Lys
    290                 295                 300
Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn Val
305                 310                 315                 320
Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp Ala
                325                 330                 335
Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu Ser
            340                 345                 350
Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu Phe
        355                 360                 365
Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile Ile
    370                 375                 380
Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu Ser
385                 390                 395                 400
Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys Trp
                405                 410                 415
Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly Gln
            420                 425                 430
Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met Ala
        435                 440                 445
Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser Asn
    450                 455                 460
Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala Thr
465                 470                 475                 480
Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu His
                485                 490                 495
Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys Gly
            500                 505                 510
Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met Ala
        515                 520                 525
Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu Gln
    530                 535                 540
Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val Lys
545                 550                 555                 560
Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys Tyr
                565                 570                 575
Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala
            580                 585

<210> 444
<211> 601
<212> PRT
<213> Homo sapiens

<400> 444
Met Ala Gly Ala Ser Glu Leu Gly Thr Gly Pro Gly Ala Ala Gly Gly
 1               5                  10                  15
Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu Ile Asp Glu Leu
            20                  25                  30
Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile Lys Lys Leu Ser
        35                  40                  45
Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg Ser Glu Leu Leu
    50                  55                  60
Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu Val Leu Leu Ala
65                  70                  75                  80
Leu Ala Glu Gln Leu Gly Asn Phe Thr Gly Leu Val Gly Gly Pro Asp
                85                  90                  95
Phe Ala His Cys Leu Leu Pro Pro Leu Glu Asn Leu Ala Thr Val Glu
            100                 105                 110
Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu Arg Gln Ile Ser
        115                 120                 125
Gln Glu His Thr Pro Val Ala Leu Glu Ala Tyr Phe Val Pro Leu Val
    130                 135                 140
Lys Arg Leu Ala Ser Gly Asp Trp Phe Thr Ser Arg Thr Ser Ala Cys
145                 150                 155                 160
Gly Leu Phe Ser Val Cys Tyr Pro Arg Ala Ser Asn Ala Val Lys Ala
                165                 170                 175
Glu Thr Arg Gln Gln Phe Arg Ser Leu Cys Ser Asp Asp Thr Pro Met
            180                 185                 190
Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe Ala Lys Val Leu
        195                 200                 205
Glu Leu Asp Ser Val Lys Ser Glu Ile Val Pro Leu Phe Thr Ser Leu
    210                 215                 220
Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala Val Glu Ala Cys
225                 230                 235                 240
Val Ser Ile Ala Gln Leu Leu Ser Gln Asp Asp Leu Glu Thr Leu Val
                245                 250                 255
Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser Trp Arg Val Arg
            260                 265                 270
Tyr Met Val Ala Asp Arg Phe Ser Glu Leu Gln Lys Ala Met Gly Pro
        275                 280                 285
Lys Ile Thr Leu Asn Asp Leu Ile Pro Ala Phe Gln Asn Leu Leu Lys
    290                 295                 300
Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ala His Lys Val Lys Glu
305                 310                 315                 320
Leu Gly Glu Asn Leu Pro Ile Glu Asp Arg Glu Thr Ile Ile Met Asn
                325                 330                 335
Gln Ile Leu Pro Tyr Ile Lys Glu Leu Val Ser Asp Thr Asn Gln His
            340                 345                 350
Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu Ser Thr Ile Leu
        355                 360                 365
Gly Lys Glu Asn Thr Ile Glu His Leu Leu Pro Leu Phe Leu Ala Gln
    370                 375                 380
Leu Lys Asp Glu Cys Pro Asp Val Arg Leu Asn Ile Ile Ser Asn Leu
385                 390                 395                 400
Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu Ser Gln Ser Leu
                405                 410                 415
Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys Trp Arg Val Arg
            420                 425                 430
Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly Gln Leu Gly Val
        435                 440                 445
Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met Ala Trp Leu Val
    450                 455                 460
Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Asn Asn Leu Met Lys
465                 470                 475                 480
Leu Val Gln Lys Phe Gly Thr Glu Trp Ala Gln Asn Thr Ile Val Pro
                485                 490                 495
Lys Val Leu Val Met Ala Asn Asp Pro Asn Tyr Leu His Arg Met Thr
            500                 505                 510
Thr Leu Phe Cys Ile Asn Ala Leu Ser Glu Ala Cys Gly Gln Glu Ile
        515                 520                 525
Thr Thr Lys Gln Met Leu Pro Ile Val Leu Lys Met Ala Gly Asp Gln
    530                 535                 540
Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu Gln Lys Ile Gly
545                 550                 555                 560
Pro Ile Leu Asp Thr Asn Ala Leu Gln Gly Glu Val Lys Pro Val Leu
                565                 570                 575
Gln Lys Leu Gly Gln Asp Glu Asp Met Asp Val Lys Tyr Phe Ala Gln
            580                 585                 590
Glu Ala Ile Ser Val Leu Ala Leu Ala
        595                 600

<210> 445
<211> 589
<212> PRT
<213> Homo sapiens

<400> 445
Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu
 1               5                  10                  15
Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile
            20                  25                  30
Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg
        35                  40                  45
Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu
    50                  55                  60
Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val
65                  70                  75                  80
Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu
                85                  90                  95
Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu
            100                 105                 110
Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe
        115                 120                 125
Val Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg
    130                 135                 140
Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser
145                 150                 155                 160
Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp
                165                 170                 175
Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe
            180                 185                 190
Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met
        195                 200                 205
Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala
    210                 215                 220
Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu
225                 230                 235                 240
Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser
                245                 250                 255
Trp Arg Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys
            260                 265                 270
Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln
        275                 280                 285
Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His
    290                 295                 300
Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn
305                 310                 315                 320
Val Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp
                325                 330                 335
Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu
            340                 345                 350
Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu
        355                 360                 365
Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile
    370                 375                 380
Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu
385                 390                 395                 400
Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys
                405                 410                 415
Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly
            420                 425                 430
Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met
        435                 440                 445
Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser
    450                 455                 460
Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala
465                 470                 475                 480
Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu
                485                 490                 495
His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys
            500                 505                 510
Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met
        515                 520                 525
Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu
    530                 535                 540
Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val
545                 550                 555                 560
Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys
                565                 570                 575
Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala
            580                 585

<210> 446
<211> 572
<212> PRT
<213> Homo sapiens

<400> 446
Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr
 1               5                  10                  15
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu
            20                  25                  30
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe
        35                  40                  45
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His
    50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp
65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys
                85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln
            100                 105                 110
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His
        115                 120                 125
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val
    130                 135                 140
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly
145                 150                 155                 160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu
                165                 170                 175
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile
            180                 185                 190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr
        195                 200                 205
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe
    210                 215                 220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys
225                 230                 235                 240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu
                245                 250                 255
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly
            260                 265                 270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr
        275                 280                 285
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu
    290                 295                 300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu
305                 310                 315                 320
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser
                325                 330                 335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu
            340                 345                 350
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val
        355                 360                 365
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly
    370                 375                 380
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg
385                 390                 395                 400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser
                405                 410                 415
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser
            420                 425                 430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asp Gly Arg Thr Leu Phe
        435                 440                 445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly
    450                 455                 460
Val Val Ala Cys Gly Leu Arg His Ile Asp Asp Lys Val Phe Leu Thr
465                 470                 475                 480
Thr Ala Glu Val Ile Ser Gln Gln Val Ser Asp Lys His Leu Gln Glu
                485                 490                 495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys
            500                 505                 510
Ile Ala Val Lys Ile Val Gln Asp Ala Tyr Lys Glu Lys Met Ala Thr
        515                 520                 525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Glu Phe Val Ser Ser Gln Met
    530                 535                 540
Tyr Ser Thr Asn Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Pro Trp Pro
545                 550                 555                 560
Ala Glu Val Gln Lys Ile Gln Thr Lys Val Asn Gln
                565                 570

<210> 447
<211> 565
<212> PRT
<213> Homo sapiens

<400> 447
Arg Arg His Thr His Gln Arg Gly Tyr Leu Leu Thr Arg Asn Pro His
 1               5                  10                  15
Leu Asn Lys Asp Leu Ala Phe Thr Leu Glu Glu Arg Gln Gln Leu Asn
            20                  25                  30
Ile His Gly Leu Leu Pro Pro Ser Phe Asn Ser Gln Glu Ile Gln Val
        35                  40                  45
Leu Arg Val Val Lys Asn Phe Glu His Leu Asn Ser Asp Phe Asp Arg
    50                  55                  60
Tyr Leu Leu Leu Met Asp Leu Gln Asp Arg Asn Glu Lys Leu Phe Tyr
65                  70                  75                  80
Arg Val Leu Thr Ser Asp Ile Glu Lys Phe Met Pro Ile Val Tyr Thr
                85                  90                  95
Pro Thr Val Gly Leu Ala Cys Gln Gln Tyr Ser Leu Val Phe Arg Lys
            100                 105                 110
Pro Arg Gly Leu Phe Ile Thr Ile His Asp Arg Gly His Ile Ala Ser
        115                 120                 125
Val Leu Asn Ala Trp Pro Glu Asp Val Ile Lys Ala Ile Val Val Thr
    130                 135                 140
Asp Gly Glu Arg Ile Leu Gly Leu Gly Asp Leu Gly Cys Asn Gly Met
145                 150                 155                 160
Gly Ile Pro Val Gly Lys Leu Ala Leu Tyr Thr Ala Cys Gly Gly Met
                165                 170                 175
Asn Pro Gln Glu Cys Leu Pro Val Ile Leu Asp Val Gly Thr Glu Asn
            180                 185                 190
Glu Glu Leu Leu Lys Asp Pro Leu Tyr Ile Gly Leu Arg Gln Arg Arg
        195                 200                 205
Val Arg Gly Ser Glu Tyr Asp Asp Phe Leu Asp Glu Phe Met Glu Ala
    210                 215                 220
Val Ser Ser Lys Tyr Gly Met Asn Cys Leu Ile Gln Phe Glu Asp Phe
225                 230                 235                 240
Ala Asn Val Asn Ala Phe Arg Leu Leu Asn Lys Tyr Arg Asn Gln Tyr
                245                 250                 255
Cys Thr Phe Asn Asp Asp Ile Gln Gly Thr Ala Ser Val Ala Val Ala
            260                 265                 270
Gly Leu Leu Ala Ala Leu Arg Ile Thr Lys Asn Lys Leu Ser Asp Gln
        275                 280                 285
Thr Ile Leu Phe Gln Gly Ala Gly Glu Ala Ala Leu Gly Ile Ala His
    290                 295                 300
Leu Ile Val Met Ala Leu Glu Lys Glu Gly Leu Pro Lys Glu Lys Ala
305                 310                 315                 320
Ile Lys Lys Ile Trp Leu Val Asp Ser Lys Gly Leu Ile Val Lys Gly
                325                 330                 335
Arg Ala Ser Leu Thr Gln Glu Lys Glu Lys Phe Ala His Glu His Glu
            340                 345                 350
Glu Met Lys Asn Leu Glu Ala Ile Val Gln Glu Ile Lys Pro Thr Ala
        355                 360                 365
Leu Ile Gly Val Ala Ala Ile Gly Gly Ala Phe Ser Glu Gln Ile Leu
    370                 375                 380
Lys Asp Met Ala Ala Phe Asn Glu Arg Pro Ile Ile Phe Ala Leu Ser
385                 390                 395                 400
Asn Pro Thr Ser Lys Ala Glu Cys Ser Ala Glu Gln Cys Tyr Lys Ile
                405                 410                 415
Thr Lys Gly Arg Ala Ile Phe Ala Ser Gly Ser Pro Phe Asp Ser Val
            420                 425                 430
Thr Leu Pro Asn Gly Gln Thr Leu Tyr Pro Gly Gln Gly Asn Asn Ser
        435                 440                 445
Tyr Val Phe Pro Gly Val Ala Leu Gly Val Val Ala Cys Gly Leu Arg
    450                 455                 460
Gln Ile Thr Asp Asn Ile Phe Leu Thr Thr Ala Glu Val Ile Ala Gln
465                 470                 475                 480
Gln Val Ser Asp Lys His Leu Glu Glu Gly Arg Leu Tyr Pro Pro Leu
                485                 490                 495
Asn Thr Ile Arg Asp Val Ser Leu Lys Ile Ala Glu Lys Ile Val Lys
            500                 505                 510
Asp Ala Tyr Gln Glu Lys Thr Ala Thr Val Tyr Pro Glu Pro Gln Asn
        515                 520                 525
Lys Glu Ala Phe Val Arg Ser Gln Met Tyr Ser Thr Asp Tyr Asp Gln
    530                 535                 540
Ile Leu Pro Asp Cys Tyr Ser Trp Pro Glu Glu Val Gln Lys Ile Gln
545                 550                 555                 560
Thr Lys Val Asp Gln
                565

<210> 448
<211> 572
<212> PRT
<213> Homo sapiens

<400> 448
Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr
 1               5                  10                  15
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu
            20                  25                  30
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe
        35                  40                  45
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His
    50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp
65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys
                85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln
            100                 105                 110
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His
        115                 120                 125
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val
    130                 135                 140
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly
145                 150                 155                 160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu
                165                 170                 175
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile
            180                 185                 190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr
        195                 200                 205
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe
    210                 215                 220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys
225                 230                 235                 240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu
                245                 250                 255
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly
            260                 265                 270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr
        275                 280                 285
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu
    290                 295                 300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu
305                 310                 315                 320
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser
                325                 330                 335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu
            340                 345                 350
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val
        355                 360                 365
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly
    370                 375                 380
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg
385                 390                 395                 400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser
                405                 410                 415
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser
            420                 425                 430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr
        435                 440                 445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly
    450                 455                 460
Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr
465                 470                 475                 480
Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu
                485                 490                 495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys
            500                 505                 510
Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr
        515                 520                 525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met
    530                 535                 540
Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro
545                 550                 555                 560
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln
                565                 570

<210> 449
<211> 572
<212> PRT
<213> Homo sapiens

<400> 449
Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr
 1               5                  10                  15
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu
            20                  25                  30
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe
        35                  40                  45
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His
    50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp
65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys
                85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln
            100                 105                 110
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His
        115                 120                 125
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val
    130                 135                 140
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly
145                 150                 155                 160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu
                165                 170                 175
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile
            180                 185                 190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr
        195                 200                 205
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe
    210                 215                 220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys
225                 230                 235                 240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu
                245                 250                 255
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly
            260                 265                 270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr
        275                 280                 285
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu
    290                 295                 300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu
305                 310                 315                 320
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser
                325                 330                 335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu
            340                 345                 350
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val
        355                 360                 365
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly
    370                 375                 380
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg
385                 390                 395                 400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser
                405                 410                 415
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser
            420                 425                 430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr
        435                 440                 445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly
    450                 455                 460
Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr
465                 470                 475                 480
Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu
                485                 490                 495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys
            500                 505                 510
Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr
        515                 520                 525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met
    530                 535                 540
Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro
545                 550                 555                 560
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln
                565                 570

<210> 450
<211> 572
<212> PRT
<213> Homo sapiens

<400> 450
Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr
 1               5                  10                  15
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu
            20                  25                  30
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe
        35                  40                  45
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His
    50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp
65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys
                85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln
            100                 105                 110
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His
        115                 120                 125
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val
    130                 135                 140
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly
145                 150                 155                 160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu
                165                 170                 175
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile
            180                 185                 190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr
        195                 200                 205
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe
    210                 215                 220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys
225                 230                 235                 240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu
                245                 250                 255
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly
            260                 265                 270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr
        275                 280                 285
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu
    290                 295                 300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu
305                 310                 315                 320
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser
                325                 330                 335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu
            340                 345                 350
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val
        355                 360                 365
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly
    370                 375                 380
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg
385                 390                 395                 400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser
                405                 410                 415
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser
            420                 425                 430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr
        435                 440                 445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly
    450                 455                 460
Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr
465                 470                 475                 480
Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu
                485                 490                 495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys
            500                 505                 510
Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr
        515                 520                 525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met
    530                 535                 540
Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro
545                 550                 555                 560
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln
                565                 570

<210> 451
<211> 572
<212> PRT
<213> Homo sapiens

<400> 451
Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr
 1               5                  10                  15
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu
            20                  25                  30
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe
        35                  40                  45
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His
    50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp
65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys
                85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln
            100                 105                 110
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His
        115                 120                 125
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val
    130                 135                 140
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly
145                 150                 155                 160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu
                165                 170                 175
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile
            180                 185                 190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr
        195                 200                 205
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe
    210                 215                 220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys
225                 230                 235                 240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu
                245                 250                 255
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly
            260                 265                 270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr
        275                 280                 285
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu
    290                 295                 300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu
305                 310                 315                 320
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser
                325                 330                 335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu
            340                 345                 350
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val
        355                 360                 365
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly
    370                 375                 380
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg
385                 390                 395                 400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser
                405                 410                 415
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser
            420                 425                 430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr
        435                 440                 445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly
    450                 455                 460
Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr
465                 470                 475                 480
Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu
                485                 490                 495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys
            500                 505                 510
Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr
        515                 520                 525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met
    530                 535                 540
Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro
545                 550                 555                 560
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln
                565                 570

<210> 452
<211> 572
<212> PRT
<213> Homo sapiens

<400> 452
Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr
 1               5                  10                  15
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu
            20                  25                  30
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe
        35                  40                  45
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His
    50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp
65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys
                85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln
            100                 105                 110
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His
        115                 120                 125
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val
    130                 135                 140
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly
145                 150                 155                 160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu
                165                 170                 175
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile
            180                 185                 190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr
        195                 200                 205
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe
    210                 215                 220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys
225                 230                 235                 240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu
                245                 250                 255
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly
            260                 265                 270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr
        275                 280                 285
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu
    290                 295                 300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu
305                 310                 315                 320
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser
                325                 330                 335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu
            340                 345                 350
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val
        355                 360                 365
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly
    370                 375                 380
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg
385                 390                 395                 400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser
                405                 410                 415
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser
            420                 425                 430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr
        435                 440                 445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly
    450                 455                 460
Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr
465                 470                 475                 480
Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu
                485                 490                 495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys
            500                 505                 510
Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr
        515                 520                 525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met
    530                 535                 540
Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro
545                 550                 555                 560
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln
                565                 570

<210> 453
<211> 572
<212> PRT
<213> Homo sapiens

<400> 453
Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr
 1               5                  10                  15
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu
            20                  25                  30
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe
        35                  40                  45
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His
    50                  55                  60
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp
65                  70                  75                  80
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys
                85                  90                  95
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln
            100                 105                 110
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His
        115                 120                 125
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val
    130                 135                 140
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly
145                 150                 155                 160
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu
                165                 170                 175
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile
            180                 185                 190
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr
        195                 200                 205
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe
    210                 215                 220
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys
225                 230                 235                 240
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu
                245                 250                 255
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly
            260                 265                 270
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr
        275                 280                 285
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu
    290                 295                 300
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu
305                 310                 315                 320
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser
                325                 330                 335
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu
            340                 345                 350
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val
        355                 360                 365
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly
    370                 375                 380
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg
385                 390                 395                 400
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser
                405                 410                 415
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser
            420                 425                 430
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asp Gly Arg Thr Leu Phe
        435                 440                 445
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly
    450                 455                 460
Val Val Ala Cys Gly Leu Arg His Ile Asp Asp Lys Val Phe Leu Thr
465                 470                 475                 480
Thr Ala Glu Val Ile Ser Gln Gln Val Ser Asp Lys His Leu Gln Glu
                485                 490                 495
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys
            500                 505                 510
Ile Ala Val Lys Ile Val Gln Asp Ala Tyr Lys Glu Lys Met Ala Thr
        515                 520                 525
Val Tyr Pro Glu Pro Gln Asn Lys Glu Glu Phe Val Ser Ser Gln Met
    530                 535                 540
Tyr Ser Thr Asn Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Pro Trp Pro
545                 550                 555                 560
Ala Glu Val Gln Lys Ile Gln Thr Lys Val Asn Gln
                565                 570

<210> 454
<211> 656
<212> PRT
<213> Homo sapiens

<400> 454
Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys Leu Arg Asn Leu Glu
 1               5                  10                  15
Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met Asn Lys Gly
            20                  25                  30
Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys Tyr Gln Glu
        35                  40                  45
Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg Ser Phe Met
    50                  55                  60
Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr Ala Arg Arg
65                  70                  75                  80
Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu Lys Thr Val
                85                  90                  95
Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp Glu Val Arg
            100                 105                 110
Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu Ser Glu Glu
        115                 120                 125
Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp Pro Glu Arg
    130                 135                 140
Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala Ser Ile His
145                 150                 155                 160
Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys Gly Thr Thr
                165                 170                 175
Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val Phe Gln Ser Asn Tyr
            180                 185                 190
Phe Asp Ser Thr His Asn His Gln Asn Gly Leu Cys Glu Glu Glu Glu
        195                 200                 205
Ala Ala Ser Ala Pro Ala Val Glu Asp Gln Val Pro Glu Ala Glu Pro
    210                 215                 220
Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu Val Glu Ser Thr Glu
225                 230                 235                 240
Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln Phe Thr Ser Gly Glu
                245                 250                 255
Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr Val Glu Val Val Asn
            260                 265                 270
Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro Ser Val Pro Glu Pro
        275                 280                 285
His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro Leu Val Arg Arg Gln
    290                 295                 300
Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly Pro Tyr Asn Phe Ile
305                 310                 315                 320
Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr Leu Asp Pro Ala Ile
                325                 330                 335
Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn Met Asp Met Pro Gln
            340                 345                 350
Leu Val Cys Pro Pro Val His Ser Glu Ser Arg Leu Ala Gln Pro Asn
        355                 360                 365
Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val Pro Leu Val Ser Ser
    370                 375                 380
Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu Tyr Gln Pro Ser His
385                 390                 395                 400
Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile Asp Gln Ile Gln Ala
                405                 410                 415
Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala Ser Ser Ser Leu Pro
            420                 425                 430
Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly Thr Ser Lys Pro Leu
        435                 440                 445
His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro Phe Gln Ser Met Gln
    450                 455                 460
Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro Val Asn Glu Pro Glu
465                 470                 475                 480
Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser Tyr Asn Gln Ser Phe
                485                 490                 495
Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu Leu Gln Gln Glu Gln
            500                 505                 510
Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser Pro Asp Gln Ser His
        515                 520                 525
Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln Gln Asn Thr Gly Phe
    530                 535                 540
Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg Gly Val Ser Arg Gly
545                 550                 555                 560
Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly Tyr Arg Gly Pro Ala
                565                 570                 575
Asn Gly Phe Arg Gly Gly Tyr Asp Gly Tyr Arg Pro Ser Phe Ser Asn
            580                 585                 590
Thr Pro Asn Ser Gly Tyr Thr Gln Ser Gln Phe Ser Ala Pro Arg Asp
        595                 600                 605
Tyr Ser Gly Tyr Gln Arg Asp Gly Tyr Gln Gln Asn Phe Lys Arg Gly
    610                 615                 620
Ser Gly Gln Ser Gly Pro Arg Gly Ala Pro Arg Gly Arg Gly Gly Pro
625                 630                 635                 640
Pro Arg Pro Asn Arg Gly Met Pro Gln Met Asn Thr Gln Gln Val Asn
                645                 650                 655

<210> 455
<211> 649
<212> PRT
<213> Homo sapiens

<400> 455
Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys Leu Arg Asn Leu Glu
 1               5                  10                  15
Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met Asn Lys Gly
            20                  25                  30
Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys Tyr Gln Glu
        35                  40                  45
Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg Ser Phe Met
    50                  55                  60
Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr Ala Arg Arg
65                  70                  75                  80
Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu Lys Thr Val
                85                  90                  95
Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp Glu Val Arg
            100                 105                 110
Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu Ser Glu Glu
        115                 120                 125
Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp Pro Glu Arg
    130                 135                 140
Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala Ser Ile His
145                 150                 155                 160
Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys Gly Thr Thr
                165                 170                 175
Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val Phe Gln Ser Asn Tyr
            180                 185                 190
Phe Asp Ser Thr His Asn His Gln Asn Gly Leu Cys Glu Glu Glu Glu
        195                 200                 205
Ala Asp Ser Ala Pro Ala Val Glu Asp Gln Val Pro Glu Ala Glu Pro
    210                 215                 220
Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu Val Glu Ser Thr Glu
225                 230                 235                 240
Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln Phe Thr Ser Gly Glu
                245                 250                 255
Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr Val Glu Val Val Asn
            260                 265                 270
Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro Ser Val Pro Glu Pro
        275                 280                 285
His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro Leu Val Arg Arg Gln
    290                 295                 300
Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly Pro Asp Asn Phe Ile
305                 310                 315                 320
Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr Leu Asp Pro Ala Ile
                325                 330                 335
Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn Met Asp Met Pro Gln
            340                 345                 350
Leu Val Cys Pro Pro Val His Ser Glu Ser Arg Leu Ala Gln Pro Asn
        355                 360                 365
Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val Pro Leu Val Ser Ser
    370                 375                 380
Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu Tyr Gln Pro Ser His
385                 390                 395                 400
Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile Asp Gln Ile Gln Ala
                405                 410                 415
Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala Ser Ser Ser Leu Pro
            420                 425                 430
Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly Thr Ser Lys Pro Leu
        435                 440                 445
His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro Phe Gln Ser Met Gln
    450                 455                 460
Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro Val Asn Glu Pro Glu
465                 470                 475                 480
Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser Tyr Asn Gln Ser Phe
                485                 490                 495
Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu Leu Gln Gln Glu Gln
            500                 505                 510
Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser Pro Asp Gln Ser His
        515                 520                 525
Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln Gln Asn Thr Gly Phe
    530                 535                 540
Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg Gly Val Ser Arg Gly
545                 550                 555                 560
Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly Tyr Arg Gly Pro Ala
                565                 570                 575
Met Asp Ser Glu Glu Asp Met Met Val Thr Ala Leu His Ser Leu Thr
            580                 585                 590
Leu Gln Thr Val Val Ile His Ser Leu Ser Ser Val Leu Pro Gly Ile
        595                 600                 605
Thr Leu Ala Ile Asn Gly Met Asp Ile Ser Arg Ile Ser Ser Glu Ala
    610                 615                 620
Leu Gly Arg Val Asp His Gly Glu Pro His Glu Val Val Glu Gly Pro
625                 630                 635                 640
Gln Asp Pro Thr Glu Gly Cys Arg Lys
                645

<210> 456
<211> 656
<212> PRT
<213> Homo sapiens

<400> 456
Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys Leu Arg Asn Leu Glu
 1               5                  10                  15
Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met Asn Lys Gly
            20                  25                  30
Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys Tyr Gln Glu
        35                  40                  45
Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg Ser Phe Met
    50                  55                  60
Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr Ala Arg Arg
65                  70                  75                  80
Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu Lys Thr Val
                85                  90                  95
Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp Glu Val Arg
            100                 105                 110
Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu Ser Glu Glu
        115                 120                 125
Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp Pro Glu Arg
    130                 135                 140
Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala Ser Ile His
145                 150                 155                 160
Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys Gly Thr Thr
                165                 170                 175
Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val Phe Gln Ser Asn Tyr
            180                 185                 190
Phe Asp Ser Thr His Asn His Gln Asn Gly Leu Cys Glu Glu Glu Glu
        195                 200                 205
Ala Ala Ser Ala Pro Ala Val Glu Asp Gln Val Pro Glu Ala Glu Pro
    210                 215                 220
Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu Val Glu Ser Thr Glu
225                 230                 235                 240
Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln Phe Thr Ser Gly Glu
                245                 250                 255
Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr Val Glu Val Val Asn
            260                 265                 270
Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro Ser Val Pro Glu Pro
        275                 280                 285
His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro Leu Val Arg Arg Gln
    290                 295                 300
Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly Pro Tyr Asn Phe Ile
305                 310                 315                 320
Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr Leu Asp Pro Ala Ile
                325                 330                 335
Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn Met Asp Met Pro Gln
            340                 345                 350
Leu Val Cys Pro Pro Val His Ser Glu Ser Arg Leu Ala Gln Pro Asn
        355                 360                 365
Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val Pro Leu Val Ser Ser
    370                 375                 380
Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu Tyr Gln Pro Ser His
385                 390                 395                 400
Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile Asp Gln Ile Gln Ala
                405                 410                 415
Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala Ser Ser Ser Leu Pro
            420                 425                 430
Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly Thr Ser Lys Pro Leu
        435                 440                 445
His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro Phe Gln Ser Met Gln
    450                 455                 460
Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro Val Asn Glu Pro Glu
465                 470                 475                 480
Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser Tyr Asn Gln Ser Phe
                485                 490                 495
Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu Leu Gln Gln Glu Gln
            500                 505                 510
Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser Pro Asp Gln Ser His
        515                 520                 525
Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln Gln Asn Thr Gly Phe
    530                 535                 540
Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg Gly Val Ser Arg Gly
545                 550                 555                 560
Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly Tyr Arg Gly Pro Ala
                565                 570                 575
Asn Gly Phe Arg Gly Gly Tyr Asp Gly Tyr Arg Pro Ser Phe Ser Asn
            580                 585                 590
Thr Pro Asn Ser Gly Tyr Thr Gln Ser Gln Phe Ser Ala Pro Arg Asp
        595                 600                 605
Tyr Ser Gly Tyr Gln Arg Asp Gly Tyr Gln Gln Asn Phe Lys Arg Gly
    610                 615                 620
Ser Gly Gln Ser Gly Pro Arg Gly Ala Pro Arg Gly Arg Gly Gly Pro
625                 630                 635                 640
Pro Arg Pro Asn Arg Gly Met Pro Gln Met Asn Thr Gln Gln Val Asn
                645                 650                 655

<210> 457
<211> 710
<212> PRT
<213> Homo sapiens

<400> 457
Arg Cys Pro Arg Pro Pro Ala Thr Ala Gly Ala Ala Ala Ser Arg Pro
 1               5                  10                  15
Asp Arg Ser Pro Pro Ser Gly Ile Ser Gly Ser Glu Ala Ala Ala Gly
            20                  25                  30
Ala Gly Ala Ala Ala Pro Ala Ser Gln His Pro Ala Thr Gly Thr Gly
        35                  40                  45
Ala Val Gln Thr Glu Ala Met Lys Gln Ile Leu Gly Val Ile Asp Lys
    50                  55                  60
Lys Leu Arg Asn Leu Glu Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln
65                  70                  75                  80
Glu Arg Met Asn Lys Gly Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala
                85                  90                  95
Val Ser Lys Tyr Gln Glu Val Thr Asn Asn Leu Glu Phe Ala Lys Glu
            100                 105                 110
Leu Gln Arg Ser Phe Met Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile
        115                 120                 125
Lys Lys Thr Ala Arg Arg Glu Gln Leu Met Arg Glu Glu Ala Glu Gln
    130                 135                 140
Lys Arg Leu Lys Thr Val Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu
145                 150                 155                 160
Gly Asp Asp Glu Val Arg Thr Asp Leu Lys Gln Gly Leu Asn Gly Val
                165                 170                 175
Pro Ile Leu Ser Glu Glu Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys
            180                 185                 190
Leu Val Asp Pro Glu Arg Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr
        195                 200                 205
Glu His Ala Ser Ile His Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys
    210                 215                 220
Pro Val Cys Gly Thr Thr Tyr Lys Val Leu Lys Glu Ile Val Glu Arg
225                 230                 235                 240
Val Phe Gln Ser Asn Tyr Phe Asp Ser Thr His Asn His Gln Asn Gly
                245                 250                 255
Leu Cys Glu Glu Glu Glu Ala Ala Ser Ala Pro Ala Val Glu Asp Gln
            260                 265                 270
Val Pro Glu Ala Glu Pro Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser
        275                 280                 285
Glu Val Glu Ser Thr Glu Tyr Val Asn Arg Gln Phe Met Ala Glu Thr
    290                 295                 300
Gln Phe Thr Ser Gly Glu Lys Glu Gln Val Asp Glu Trp Thr Val Glu
305                 310                 315                 320
Thr Val Glu Val Val Asn Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser
                325                 330                 335
Pro Ser Val Pro Glu Pro His Ser Leu Thr Pro Val Ala Gln Ala Asp
            340                 345                 350
Pro Leu Val Arg Arg Gln Arg Val Gln Asp Leu Met Ala Gln Met Gln
        355                 360                 365
Gly Pro Tyr Asn Phe Ile Gln Asp Ser Met Leu Asp Phe Glu Asn Gln
    370                 375                 380
Thr Leu Asp Pro Ala Ile Val Ser Ala Gln Pro Met Asn Pro Thr Gln
385                 390                 395                 400
Asn Met Asp Met Pro Gln Leu Val Cys Pro Pro Val His Ser Glu Ser
                405                 410                 415
Arg Leu Ala Gln Pro Asn Gln Val Pro Val Gln Pro Glu Ala Thr Gln
            420                 425                 430
Val Pro Leu Val Ser Ser Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro
        435                 440                 445
Leu Tyr Gln Pro Ser His Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro
    450                 455                 460
Ile Asp Gln Ile Gln Ala Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr
465                 470                 475                 480
Ala Ser Ser Ser Leu Pro Ala Ala Ser Gln Pro Gln Val Phe Gln Ala
                485                 490                 495
Gly Thr Ser Lys Pro Leu His Ser Ser Gly Ile Asn Val Asn Ala Ala
            500                 505                 510
Pro Phe Gln Ser Met Gln Thr Val Phe Asn Met Asn Ala Pro Val Pro
        515                 520                 525
Pro Val Asn Glu Pro Glu Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala
    530                 535                 540
Ser Tyr Asn Gln Ser Phe Ser Ser Gln Pro His Gln Val Glu Gln Thr
545                 550                 555                 560
Glu Leu Gln Gln Glu Gln Leu Gln Thr Val Val Gly Thr Tyr His Gly
                565                 570                 575
Ser Pro Asp Gln Ser His Gln Val Thr Gly Asn His Gln Gln Pro Pro
            580                 585                 590
Gln Gln Asn Thr Gly Phe Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser
        595                 600                 605
Arg Gly Val Ser Arg Gly Gly Ser Arg Gly Ala Arg Gly Leu Met Asn
    610                 615                 620
Gly Tyr Arg Gly Pro Ala Asn Gly Phe Arg Gly Gly Tyr Asp Gly Tyr
625                 630                 635                 640
Arg Pro Ser Phe Ser Asn Thr Pro Asn Ser Gly Tyr Thr Gln Ser Gln
                645                 650                 655
Phe Ser Ala Pro Arg Asp Tyr Ser Gly Tyr Gln Arg Asp Gly Tyr Gln
            660                 665                 670
Gln Asn Phe Lys Arg Gly Ser Gly Gln Ser Gly Pro Arg Gly Ala Pro
        675                 680                 685
Arg Gly Arg Gly Gly Pro Pro Arg Pro Asn Arg Gly Met Pro Gln Met
    690                 695                 700
Asn Thr Gln Gln Val Asn
705                 710

<210> 458
<211> 649
<212> PRT
<213> Homo sapiens

<400> 458
Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys Leu Arg Asn Leu Glu
 1               5                  10                  15
Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met Asn Lys Gly
            20                  25                  30
Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys Tyr Gln Glu
        35                  40                  45
Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg Ser Phe Met
    50                  55                  60
Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr Ala Arg Arg
65                  70                  75                  80
Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu Lys Thr Val
                85                  90                  95
Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp Glu Val Arg
            100                 105                 110
Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu Ser Glu Glu
        115                 120                 125
Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp Pro Glu Arg
    130                 135                 140
Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala Ser Ile His
145                 150                 155                 160
Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys Gly Thr Thr
                165                 170                 175
Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val Phe Gln Ser Asn Tyr
            180                 185                 190
Phe Asp Ser Thr His Asn His Gln Asn Gly Leu Cys Glu Glu Glu Glu
        195                 200                 205
Ala Ala Ser Ala Pro Ala Val Glu Asp Gln Val Pro Glu Ala Glu Pro
    210                 215                 220
Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu Val Glu Ser Thr Glu
225                 230                 235                 240
Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln Phe Thr Ser Gly Glu
                245                 250                 255
Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr Val Glu Val Val Asn
            260                 265                 270
Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro Ser Val Pro Glu Pro
        275                 280                 285
His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro Leu Val Arg Arg Gln
    290                 295                 300
Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly Pro Asp Asn Phe Ile
305                 310                 315                 320
Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr Leu Asp Pro Ala Ile
                325                 330                 335
Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn Met Asp Met Pro Gln
            340                 345                 350
Leu Val Cys Pro Pro Val His Ser Glu Ser Arg Leu Ala Gln Pro Asn
        355                 360                 365
Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val Pro Leu Val Ser Ser
    370                 375                 380
Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu Tyr Gln Pro Ser His
385                 390                 395                 400
Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile Asp Gln Ile Gln Ala
                405                 410                 415
Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala Ser Ser Ser Leu Pro
            420                 425                 430
Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly Thr Ser Lys Pro Leu
        435                 440                 445
His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro Phe Gln Ser Met Gln
    450                 455                 460
Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro Val Asn Glu Pro Glu
465                 470                 475                 480
Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser Tyr Asn Gln Ser Phe
                485                 490                 495
Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu Leu Gln Gln Glu Gln
            500                 505                 510
Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser Pro Asp Gln Ser His
        515                 520                 525
Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln Gln Asn Thr Gly Phe
    530                 535                 540
Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg Gly Val Ser Arg Gly
545                 550                 555                 560
Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly Tyr Arg Gly Pro Ala
                565                 570                 575
Met Asp Ser Glu Glu Asp Met Met Val Thr Ala Leu His Ser Leu Thr
            580                 585                 590
Leu Gln Thr Val Val Ile His Ser Leu Ser Ser Val Leu Pro Gly Ile
        595                 600                 605
Thr Leu Ala Ile Asn Gly Met Asp Ile Ser Arg Ile Ser Ser Glu Ala
    610                 615                 620
Leu Gly Arg Val Asp His Gly Glu Pro His Glu Val Val Glu Gly Pro
625                 630                 635                 640
Gln Asp Pro Thr Glu Gly Cys Arg Lys
                645

<210> 459
<211> 731
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(731)
<223> Xaa = Any Amino Acid

<400> 459
Arg Leu Pro Pro Ala Phe Ser Ser Leu Ser Leu Arg Ser Glu Asp Ala
 1               5                  10                  15
Leu Gly His Gln Pro Gln Arg Glu Arg Ser Lys Ser Ser Gly Pro Pro
            20                  25                  30
Pro Pro Ser Gly Ser Ser Gly Ser Glu Ala Ala Ala Gly Ala Gly Ala
        35                  40                  45
Ala Ala Pro Ala Ser Gln His Pro Ala Thr Gly Thr Gly Ala Val Gln
    50                  55                  60
Thr Glu Ala Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys Leu Arg
65                  70                  75                  80
Asn Leu Glu Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met
                85                  90                  95
Asn Lys Gly Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys
            100                 105                 110
Tyr Gln Glu Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg
        115                 120                 125
Ser Phe Met Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr
    130                 135                 140
Ala Arg Arg Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu
145                 150                 155                 160
Lys Thr Val Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp
                165                 170                 175
Glu Val Arg Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu
            180                 185                 190
Ser Glu Glu Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp
        195                 200                 205
Pro Glu Arg Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala
    210                 215                 220
Ser Ile His Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys
225                 230                 235                 240
Gly Thr Thr Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val Phe Gln
                245                 250                 255
Ser Asn Tyr Phe Asp Ser Thr His Asn His Gln Asn Gly Leu Cys Glu
            260                 265                 270
Glu Glu Glu Ala Asp Ser Ala Pro Ala Val Glu Asp Gln Val Pro Glu
        275                 280                 285
Ala Glu Pro Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu Val Glu
    290                 295                 300
Ser Thr Glu Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln Phe Thr
305                 310                 315                 320
Ser Gly Glu Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr Val Glu
                325                 330                 335
Val Val Asn Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro Ser Val
            340                 345                 350
Pro Glu Pro His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro Leu Val
        355                 360                 365
Arg Arg Gln Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly Pro Asp
    370                 375                 380
Asn Phe Ile Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr Leu Asp
385                 390                 395                 400
Pro Ala Ile Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn Met Asp
                405                 410                 415
Met Pro Gln Leu Val Cys Pro Pro Val His Ser Glu Ser Arg Leu Ala
            420                 425                 430
Gln Pro Asn Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val Pro Leu
        435                 440                 445
Val Ser Ser Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu Tyr Gln
    450                 455                 460
Pro Ser His Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile Asp Gln
465                 470                 475                 480
Ile Gln Ala Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala Ser Ser
                485                 490                 495
Ser Leu Pro Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly Thr Ser
            500                 505                 510
Lys Pro Leu His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro Phe Gln
        515                 520                 525
Ser Met Gln Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro Val Asn
    530                 535                 540
Glu Pro Glu Thr Leu Lys Gln Gln Asn Gln Ser Gln Ala Ser Tyr Asn
545                 550                 555                 560
Gln Ser Phe Ser Ser Gln Pro Ser Pro Ser Xaa Gln Gln Thr Glu Leu
                565                 570                 575
Gln Gln Glu Gln Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser Gln
            580                 585                 590
Asp Gln Ser His Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln Gln
        595                 600                 605
Asn Thr Gly Ile Ser Thr Xaa Ala Ile Arg Pro Tyr Tyr Asn Ser Arg
    610                 615                 620
Gly Val Ser Arg Gly Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly
625                 630                 635                 640
Tyr Arg Gly Pro Ala Asn Gly Phe Arg Gly Gly Tyr Asp Gly Leu Pro
                645                 650                 655
Ala Pro Ser Phe Leu Leu Lys Leu Pro Asn Ser Gly Tyr Ser His Ser
            660                 665                 670
Pro Gln Phe Gln Cys Leu Pro Arg Asp Tyr Leu Trp Pro Ile Gln Arg
        675                 680                 685
Asp Gly Tyr Ile Gln Gln Asn Phe Lys Arg Gly Ser Gly Gln Ser Gly
    690                 695                 700
Pro Arg Gly Ala Pro Arg Gly Arg Gly Gly Pro Pro Arg Pro Asn Arg
705                 710                 715                 720
Gly Met Pro Gln Met Asn Thr Gln Gln Val Lys
                725                 730

<210> 460
<211> 162
<212> PRT
<213> Homo sapiens

<400> 460
Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met Asn Lys Gly Glu Arg
 1               5                  10                  15
Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys Tyr Gln Glu Val Thr
            20                  25                  30
Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg Ser Phe Met Ala Leu
        35                  40                  45
Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr Ala Arg Arg Glu Gln
    50                  55                  60
Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu Lys Thr Val Leu Glu
65                  70                  75                  80
Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp Glu Val Arg Thr Asp
                85                  90                  95
Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu Ser Glu Glu Glu Leu
            100                 105                 110
Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp Pro Glu Arg Asp Met
        115                 120                 125
Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala Ser Ile His Leu Trp
    130                 135                 140
Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys Gly Thr Thr Tyr Lys
145                 150                 155                 160
Val Leu


<210> 461
<211> 649
<212> PRT
<213> Homo sapiens

<400> 461
Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys Leu Arg Asn Leu Glu
 1               5                  10                  15
Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met Asn Lys Gly
            20                  25                  30
Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys Tyr Gln Glu
        35                  40                  45
Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg Ser Phe Met
    50                  55                  60
Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr Ala Arg Arg
65                  70                  75                  80
Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu Lys Thr Val
                85                  90                  95
Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp Glu Val Arg
            100                 105                 110
Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu Ser Glu Glu
        115                 120                 125
Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp Pro Glu Arg
    130                 135                 140
Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala Ser Ile His
145                 150                 155                 160
Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys Gly Thr Thr
                165                 170                 175
Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val Phe Gln Ser Asn Tyr
            180                 185                 190
Phe Asp Ser Thr His Asn His Gln Asn Gly Leu Cys Glu Glu Glu Glu
        195                 200                 205
Ala Asp Ser Ala Pro Ala Val Glu Asp Gln Val Pro Glu Ala Glu Pro
    210                 215                 220
Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu Val Glu Ser Thr Glu
225                 230                 235                 240
Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln Phe Thr Ser Gly Glu
                245                 250                 255
Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr Val Glu Val Val Asn
            260                 265                 270
Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro Ser Val Pro Glu Pro
        275                 280                 285
His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro Leu Val Arg Arg Gln
    290                 295                 300
Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly Pro Asp Asn Phe Ile
305                 310                 315                 320
Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr Leu Asp Pro Ala Ile
                325                 330                 335
Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn Met Asp Met Pro Gln
            340                 345                 350
Leu Val Cys Pro Pro Val His Ser Glu Ser Arg Leu Ala Gln Pro Asn
        355                 360                 365
Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val Pro Leu Val Ser Ser
    370                 375                 380
Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu Tyr Gln Pro Ser His
385                 390                 395                 400
Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile Asp Gln Ile Gln Ala
                405                 410                 415
Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala Ser Ser Ser Leu Pro
            420                 425                 430
Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly Thr Ser Lys Pro Leu
        435                 440                 445
His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro Phe Gln Ser Met Gln
    450                 455                 460
Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro Val Asn Glu Pro Glu
465                 470                 475                 480
Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser Tyr Asn Gln Ser Phe
                485                 490                 495
Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu Leu Gln Gln Glu Gln
            500                 505                 510
Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser Pro Asp Gln Ser His
        515                 520                 525
Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln Gln Asn Thr Gly Phe
    530                 535                 540
Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg Gly Val Ser Arg Gly
545                 550                 555                 560
Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly Tyr Arg Gly Pro Ala
                565                 570                 575
Met Asp Ser Glu Glu Asp Met Met Val Thr Ala Leu His Ser Leu Thr
            580                 585                 590
Leu Gln Thr Val Val Ile His Ser Leu Ser Ser Val Leu Pro Gly Ile
        595                 600                 605
Thr Leu Ala Ile Asn Gly Met Asp Ile Ser Arg Ile Ser Ser Glu Ala
    610                 615                 620
Leu Gly Arg Val Asp His Gly Glu Pro His Glu Val Val Glu Gly Pro
625                 630                 635                 640
Gln Asp Pro Thr Glu Gly Cys Arg Lys
                645

<210> 462
<211> 649
<212> PRT
<213> Homo sapiens

<400> 462
Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys Leu Arg Asn Leu Glu
 1               5                  10                  15
Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met Asn Lys Gly
            20                  25                  30
Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys Tyr Gln Glu
        35                  40                  45
Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg Ser Phe Met
    50                  55                  60
Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr Ala Arg Arg
65                  70                  75                  80
Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu Lys Thr Val
                85                  90                  95
Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp Glu Val Arg
            100                 105                 110
Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu Ser Glu Glu
        115                 120                 125
Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp Pro Glu Arg
    130                 135                 140
Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala Ser Ile His
145                 150                 155                 160
Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys Gly Thr Thr
                165                 170                 175
Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val Phe Gln Ser Asn Tyr
            180                 185                 190
Phe Asp Ser Thr His Asn His Gln Asn Gly Leu Cys Glu Glu Glu Glu
        195                 200                 205
Ala Asp Ser Ala Pro Ala Val Glu Asp Gln Val Pro Glu Ala Glu Pro
    210                 215                 220
Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu Val Glu Ser Thr Glu
225                 230                 235                 240
Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln Phe Thr Ser Gly Glu
                245                 250                 255
Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr Val Glu Val Val Asn
            260                 265                 270
Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro Ser Val Pro Glu Pro
        275                 280                 285
His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro Leu Val Arg Arg Gln
    290                 295                 300
Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly Pro Asp Asn Phe Ile
305                 310                 315                 320
Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr Leu Asp Pro Ala Ile
                325                 330                 335
Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn Met Asp Met Pro Gln
            340                 345                 350
Leu Val Cys Pro Pro Val His Ser Glu Ser Arg Leu Ala Gln Pro Asn
        355                 360                 365
Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val Pro Leu Val Ser Ser
    370                 375                 380
Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu Tyr Gln Pro Ser His
385                 390                 395                 400
Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile Asp Gln Ile Gln Ala
                405                 410                 415
Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala Ser Ser Ser Leu Pro
            420                 425                 430
Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly Thr Ser Lys Pro Leu
        435                 440                 445
His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro Phe Gln Ser Met Gln
    450                 455                 460
Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro Val Asn Glu Pro Glu
465                 470                 475                 480
Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser Tyr Asn Gln Ser Phe
                485                 490                 495
Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu Leu Gln Gln Glu Gln
            500                 505                 510
Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser Pro Asp Gln Ser His
        515                 520                 525
Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln Gln Asn Thr Gly Phe
    530                 535                 540
Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg Gly Val Ser Arg Gly
545                 550                 555                 560
Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly Tyr Arg Gly Pro Ala
                565                 570                 575
Met Asp Ser Glu Glu Asp Met Met Val Thr Ala Leu His Ser Leu Thr
            580                 585                 590
Leu Gln Thr Val Val Ile His Ser Leu Ser Ser Val Leu Pro Gly Ile
        595                 600                 605
Thr Leu Ala Ile Asn Gly Met Asp Ile Ser Arg Ile Ser Ser Glu Ala
    610                 615                 620
Leu Gly Arg Val Asp His Gly Glu Pro His Glu Val Val Glu Gly Pro
625                 630                 635                 640
Gln Asp Pro Thr Glu Gly Cys Arg Lys
                645

<210> 463
<211> 656
<212> PRT
<213> Homo sapiens

<400> 463
Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys Leu Arg Asn Leu Glu
 1               5                  10                  15
Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met Asn Lys Gly
            20                  25                  30
Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys Tyr Gln Glu
        35                  40                  45
Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg Ser Phe Met
    50                  55                  60
Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr Ala Arg Arg
65                  70                  75                  80
Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu Lys Thr Val
                85                  90                  95
Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp Glu Val Arg
            100                 105                 110
Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu Ser Glu Glu
        115                 120                 125
Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp Pro Glu Arg
    130                 135                 140
Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala Ser Ile His
145                 150                 155                 160
Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys Gly Thr Thr
                165                 170                 175
Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val Phe Gln Ser Asn Tyr
            180                 185                 190
Phe Asp Ser Thr His Asn His Gln Asn Gly Leu Cys Glu Glu Glu Glu
        195                 200                 205
Ala Ala Ser Ala Pro Ala Val Glu Asp Gln Val Pro Glu Ala Glu Pro
    210                 215                 220
Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu Val Glu Ser Thr Glu
225                 230                 235                 240
Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln Phe Thr Ser Gly Glu
                245                 250                 255
Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr Val Glu Val Val Asn
            260                 265                 270
Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro Ser Val Pro Glu Pro
        275                 280                 285
His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro Leu Val Arg Arg Gln
    290                 295                 300
Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly Pro Tyr Asn Phe Ile
305                 310                 315                 320
Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr Leu Asp Pro Ala Ile
                325                 330                 335
Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn Met Asp Met Pro Gln
            340                 345                 350
Leu Val Cys Pro Pro Val His Ser Glu Ser Arg Leu Ala Gln Pro Asn
        355                 360                 365
Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val Pro Leu Val Ser Ser
    370                 375                 380
Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu Tyr Gln Pro Ser His
385                 390                 395                 400
Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile Asp Gln Ile Gln Ala
                405                 410                 415
Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala Ser Ser Ser Leu Pro
            420                 425                 430
Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly Thr Ser Lys Pro Leu
        435                 440                 445
His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro Phe Gln Ser Met Gln
    450                 455                 460
Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro Val Asn Glu Pro Glu
465                 470                 475                 480
Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser Tyr Asn Gln Ser Phe
                485                 490                 495
Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu Leu Gln Gln Glu Gln
            500                 505                 510
Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser Pro Asp Gln Ser His
        515                 520                 525
Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln Gln Asn Thr Gly Phe
    530                 535                 540
Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg Gly Val Ser Arg Gly
545                 550                 555                 560
Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly Tyr Arg Gly Pro Ala
                565                 570                 575
Asn Gly Phe Arg Gly Gly Tyr Asp Gly Tyr Arg Pro Ser Phe Ser Asn
            580                 585                 590
Thr Pro Asn Ser Gly Tyr Thr Gln Ser Gln Phe Ser Ala Pro Arg Asp
        595                 600                 605
Tyr Ser Gly Tyr Gln Arg Asp Gly Tyr Gln Gln Asn Phe Lys Arg Gly
    610                 615                 620
Ser Gly Gln Ser Gly Pro Arg Gly Ala Pro Arg Gly Arg Gly Gly Pro
625                 630                 635                 640
Pro Arg Pro Asn Arg Gly Met Pro Gln Met Asn Thr Gln Gln Val Asn
                645                 650                 655

<210> 464
<211> 450
<212> PRT
<213> Homo sapiens

<400> 464
Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala
 1               5                  10                  15
Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile
            20                  25                  30
Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser
        35                  40                  45
Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg
    50                  55                  60
Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys
65                  70                  75                  80
Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg
                85                  90                  95
Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu
            100                 105                 110
Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val
        115                 120                 125
Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro
    130                 135                 140
Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser
145                 150                 155                 160
Leu Pro Ala Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg Ser
                165                 170                 175
Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr Gln
            180                 185                 190
Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro Ala
        195                 200                 205
Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala Pro
    210                 215                 220
Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg Ser
225                 230                 235                 240
Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu Tyr
                245                 250                 255
Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu Gly
            260                 265                 270
Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp Gln
        275                 280                 285
Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile Glu
    290                 295                 300
Lys Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala Pro
305                 310                 315                 320
Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp Asp
                325                 330                 335
Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg Asp
            340                 345                 350
Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu Gln
        355                 360                 365
Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr Leu
    370                 375                 380
Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu Ile
385                 390                 395                 400
Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe Ala
                405                 410                 415
Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu His
            420                 425                 430
Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser Ile
        435                 440                 445
Gln Glu
    450

<210> 465
<211> 451
<212> PRT
<213> Homo sapiens

<400> 465
Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala
 1               5                  10                  15
Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile
            20                  25                  30
Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser
        35                  40                  45
Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg
    50                  55                  60
Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys
65                  70                  75                  80
Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg
                85                  90                  95
Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu
            100                 105                 110
Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val
        115                 120                 125
Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro
    130                 135                 140
Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser
145                 150                 155                 160
Leu Pro Ala Gln Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg
                165                 170                 175
Ser Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr
            180                 185                 190
Gln Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro
        195                 200                 205
Ala Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala
    210                 215                 220
Pro Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg
225                 230                 235                 240
Ser Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu
                245                 250                 255
Tyr Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu
            260                 265                 270
Gly Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp
        275                 280                 285
Gln Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile
    290                 295                 300
Glu Lys Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala
305                 310                 315                 320
Pro Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp
                325                 330                 335
Asp Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg
            340                 345                 350
Asp Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu
        355                 360                 365
Gln Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr
    370                 375                 380
Leu Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu
385                 390                 395                 400
Ile Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe
                405                 410                 415
Ala Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu
            420                 425                 430
His Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser
        435                 440                 445
Ile Gln Glu
    450

<210> 466
<211> 451
<212> PRT
<213> Homo sapiens

<400> 466
Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala
 1               5                  10                  15
Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile
            20                  25                  30
Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser
        35                  40                  45
Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg
    50                  55                  60
Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys
65                  70                  75                  80
Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg
                85                  90                  95
Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu
            100                 105                 110
Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val
        115                 120                 125
Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro
    130                 135                 140
Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser
145                 150                 155                 160
Leu Pro Ala Gln Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg
                165                 170                 175
Ser Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr
            180                 185                 190
Gln Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro
        195                 200                 205
Ala Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala
    210                 215                 220
Pro Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg
225                 230                 235                 240
Ser Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu
                245                 250                 255
Tyr Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu
            260                 265                 270
Gly Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp
        275                 280                 285
Gln Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly His Arg Lys Asn Ile
    290                 295                 300
Glu Asn Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala
305                 310                 315                 320
Pro Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Thr Ile Tyr Trp
                325                 330                 335
Asp Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg
            340                 345                 350
Asp Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu
        355                 360                 365
Gln Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr
    370                 375                 380
Leu Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu
385                 390                 395                 400
Ile Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe
                405                 410                 415
Ala Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu
            420                 425                 430
His Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser
        435                 440                 445
Ile Gln Glu
    450

<210> 467
<211> 440
<212> PRT
<213> Homo sapiens

<400> 467
Leu Gly Pro Thr Ala Ala Leu Ser Ser Glu Ser Arg Ala Ser Ala Glu
 1               5                  10                  15
Gln Ser Gly Gly Gly Pro Arg Ala Arg Arg Gly Arg His Arg Gly Met
            20                  25                  30
Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala Val
        35                  40                  45
Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile Asp
    50                  55                  60
Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser Ile
65                  70                  75                  80
Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg Glu
                85                  90                  95
Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys Phe
            100                 105                 110
Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg Leu
        115                 120                 125
Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu Arg
    130                 135                 140
Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val Pro
145                 150                 155                 160
Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro Gln
                165                 170                 175
Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser Leu
            180                 185                 190
Pro Ala Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg Ser Trp
        195                 200                 205
Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr Gln Cys
    210                 215                 220
Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro Ala Cys
225                 230                 235                 240
Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala Pro Pro
                245                 250                 255
Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg Ser Ala
            260                 265                 270
Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu Tyr Tyr
        275                 280                 285
Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu Gly Cys
    290                 295                 300
Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp Gln Val
305                 310                 315                 320
Leu Phe Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile Glu Lys
                325                 330                 335
Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala Pro Asp
            340                 345                 350
Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp Asp Gly
        355                 360                 365
Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg Asp Gln
    370                 375                 380
Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu Gln Ala
385                 390                 395                 400
Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr Leu Cys
                405                 410                 415
Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu Ile Thr
            420                 425                 430
Ala His Val Leu Arg Ser Leu Ala
        435                 440

<210> 468
<211> 450
<212> PRT
<213> Homo sapiens

<400> 468
Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala
 1               5                  10                  15
Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile
            20                  25                  30
Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser
        35                  40                  45
Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg
    50                  55                  60
Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys
65                  70                  75                  80
Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg
                85                  90                  95
Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu
            100                 105                 110
Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val
        115                 120                 125
Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro
    130                 135                 140
Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser
145                 150                 155                 160
Leu Pro Ala Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg Ser
                165                 170                 175
Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr Gln
            180                 185                 190
Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro Ala
        195                 200                 205
Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala Pro
    210                 215                 220
Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg Ser
225                 230                 235                 240
Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu Tyr
                245                 250                 255
Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu Gly
            260                 265                 270
Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp Gln
        275                 280                 285
Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile Glu
    290                 295                 300
Lys Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala Pro
305                 310                 315                 320
Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp Asp
                325                 330                 335
Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg Asp
            340                 345                 350
Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu Gln
        355                 360                 365
Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr Leu
    370                 375                 380
Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu Ile
385                 390                 395                 400
Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe Ala
                405                 410                 415
Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu His
            420                 425                 430
Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser Ile
        435                 440                 445
Gln Glu
    450

<210> 469
<211> 451
<212> PRT
<213> Homo sapiens

<400> 469
Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala
 1               5                  10                  15
Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile
            20                  25                  30
Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser
        35                  40                  45
Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg
    50                  55                  60
Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys
65                  70                  75                  80
Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg
                85                  90                  95
Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu
            100                 105                 110
Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val
        115                 120                 125
Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro
    130                 135                 140
Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser
145                 150                 155                 160
Leu Pro Ala Gln Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg
                165                 170                 175
Ser Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr
            180                 185                 190
Gln Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro
        195                 200                 205
Ala Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala
    210                 215                 220
Pro Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg
225                 230                 235                 240
Ser Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu
                245                 250                 255
Tyr Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu
            260                 265                 270
Gly Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp
        275                 280                 285
Gln Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly His Arg Lys Asn Ile
    290                 295                 300
Glu Asn Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala
305                 310                 315                 320
Pro Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Thr Ile Tyr Trp
                325                 330                 335
Asp Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg
            340                 345                 350
Asp Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu
        355                 360                 365
Gln Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr
    370                 375                 380
Leu Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu
385                 390                 395                 400
Ile Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe
                405                 410                 415
Ala Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu
            420                 425                 430
His Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser
        435                 440                 445
Ile Gln Glu
    450

<210> 470
<211> 451
<212> PRT
<213> Homo sapiens

<400> 470
Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala
 1               5                  10                  15
Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile
            20                  25                  30
Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser
        35                  40                  45
Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg
    50                  55                  60
Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys
65                  70                  75                  80
Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg
                85                  90                  95
Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu
            100                 105                 110
Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val
        115                 120                 125
Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro
    130                 135                 140
Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser
145                 150                 155                 160
Leu Pro Ala Gln Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg
                165                 170                 175
Ser Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr
            180                 185                 190
Gln Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro
        195                 200                 205
Ala Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala
    210                 215                 220
Pro Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg
225                 230                 235                 240
Ser Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu
                245                 250                 255
Tyr Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu
            260                 265                 270
Gly Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp
        275                 280                 285
Gln Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly His Arg Lys Asn Ile
    290                 295                 300
Glu Asn Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala
305                 310                 315                 320
Pro Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Thr Ile Tyr Trp
                325                 330                 335
Asp Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg
            340                 345                 350
Asp Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu
        355                 360                 365
Gln Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr
    370                 375                 380
Leu Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu
385                 390                 395                 400
Ile Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe
                405                 410                 415
Ala Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu
            420                 425                 430
His Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser
        435                 440                 445
Ile Gln Glu
    450

<210> 471
<211> 451
<212> PRT
<213> Homo sapiens

<400> 471
Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala
 1               5                  10                  15
Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile
            20                  25                  30
Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser
        35                  40                  45
Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg
    50                  55                  60
Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys
65                  70                  75                  80
Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg
                85                  90                  95
Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu
            100                 105                 110
Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val
        115                 120                 125
Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro
    130                 135                 140
Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser
145                 150                 155                 160
Leu Pro Ala Gln Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg
                165                 170                 175
Ser Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr
            180                 185                 190
Gln Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro
        195                 200                 205
Ala Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala
    210                 215                 220
Pro Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg
225                 230                 235                 240
Ser Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu
                245                 250                 255
Tyr Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu
            260                 265                 270
Gly Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp
        275                 280                 285
Gln Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile
    290                 295                 300
Glu Lys Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala
305                 310                 315                 320
Pro Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp
                325                 330                 335
Asp Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg
            340                 345                 350
Asp Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu
        355                 360                 365
Gln Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr
    370                 375                 380
Leu Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu
385                 390                 395                 400
Ile Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe
                405                 410                 415
Ala Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu
            420                 425                 430
His Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser
        435                 440                 445
Ile Gln Glu
    450

<210> 472
<211> 440
<212> PRT
<213> Homo sapiens

<400> 472
Leu Gly Pro Thr Ala Ala Leu Ser Ser Glu Ser Arg Ala Ser Ala Glu
 1               5                  10                  15
Gln Ser Gly Gly Gly Pro Arg Ala Arg Arg Gly Arg His Arg Gly Met
            20                  25                  30
Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala Val
        35                  40                  45
Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile Asp
    50                  55                  60
Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser Ile
65                  70                  75                  80
Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg Glu
                85                  90                  95
Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys Phe
            100                 105                 110
Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg Leu
        115                 120                 125
Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu Arg
    130                 135                 140
Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val Pro
145                 150                 155                 160
Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro Gln
                165                 170                 175
Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser Leu
            180                 185                 190
Pro Ala Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg Ser Trp
        195                 200                 205
Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr Gln Cys
    210                 215                 220
Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro Ala Cys
225                 230                 235                 240
Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala Pro Pro
                245                 250                 255
Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg Ser Ala
            260                 265                 270
Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu Tyr Tyr
        275                 280                 285
Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu Gly Cys
    290                 295                 300
Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp Gln Val
305                 310                 315                 320
Leu Phe Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile Glu Lys
                325                 330                 335
Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala Pro Asp
            340                 345                 350
Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp Asp Gly
        355                 360                 365
Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg Asp Gln
    370                 375                 380
Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu Gln Ala
385                 390                 395                 400
Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr Leu Cys
                405                 410                 415
Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu Ile Thr
            420                 425                 430
Ala His Val Leu Arg Ser Leu Ala
        435                 440

<210> 473
<211> 451
<212> PRT
<213> Homo sapiens

<400> 473
Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala
 1               5                  10                  15
Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile
            20                  25                  30
Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser
        35                  40                  45
Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg
    50                  55                  60
Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys
65                  70                  75                  80
Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg
                85                  90                  95
Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu
            100                 105                 110
Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val
        115                 120                 125
Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro
    130                 135                 140
Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser
145                 150                 155                 160
Leu Pro Ala Gln Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg
                165                 170                 175
Ser Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr
            180                 185                 190
Gln Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro
        195                 200                 205
Ala Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala
    210                 215                 220
Pro Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg
225                 230                 235                 240
Ser Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu
                245                 250                 255
Tyr Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu
            260                 265                 270
Gly Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp
        275                 280                 285
Gln Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly His Arg Lys Asn Ile
    290                 295                 300
Glu Asn Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala
305                 310                 315                 320
Pro Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Thr Ile Tyr Trp
                325                 330                 335
Asp Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg
            340                 345                 350
Asp Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu
        355                 360                 365
Gln Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr
    370                 375                 380
Leu Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu
385                 390                 395                 400
Ile Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe
                405                 410                 415
Ala Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu
            420                 425                 430
His Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser
        435                 440                 445
Ile Gln Glu
    450

<210> 474
<211> 338
<212> PRT
<213> Homo sapiens

<400> 474
Met Leu Ser Ala Leu Ala Arg Pro Val Ser Ala Ala Leu Arg Arg Ser
 1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
            20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
        35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
    50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
            100                 105                 110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
        115                 120                 125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
    130                 135                 140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
145                 150                 155                 160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                165                 170                 175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
            180                 185                 190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
        195                 200                 205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
    210                 215                 220
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
225                 230                 235                 240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                245                 250                 255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
            260                 265                 270
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
        275                 280                 285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
    290                 295                 300
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
305                 310                 315                 320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                325                 330                 335
Leu Lys


<210> 475
<211> 338
<212> PRT
<213> Homo sapiens

<400> 475
Met Leu Ser Ala Leu Ala Arg Pro Val Ser Ala Ala Leu Arg Arg Ser
 1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
            20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
        35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
    50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
            100                 105                 110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
        115                 120                 125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
    130                 135                 140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
145                 150                 155                 160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                165                 170                 175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
            180                 185                 190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
        195                 200                 205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
    210                 215                 220
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
225                 230                 235                 240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                245                 250                 255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
            260                 265                 270
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
        275                 280                 285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
    290                 295                 300
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
305                 310                 315                 320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                325                 330                 335
Leu Lys


<210> 476
<211> 380
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(380)
<223> Xaa = Any Amino Acid

<400> 476
Arg Pro Glu Val Arg His Ser Arg Glu Ala Pro Glu Ser Arg Arg Trp
 1               5                  10                  15
Ala Val Trp Arg Ser Leu Glu Ser Leu Pro Arg His Gln Leu Leu Cys
            20                  25                  30
Leu Pro Val Gly Ala Pro Pro Ala Pro Ala Met Leu Ser Ala Leu Ala
        35                  40                  45
Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser Phe Ser Thr Ser Ala Gln
    50                  55                  60
Asn Asn Ala Lys Val Ala Val Leu Gly Ala Ser Gly Gly Ile Gly Gln
65                  70                  75                  80
Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro Leu Val Ser Arg Leu Thr
                85                  90                  95
Leu Tyr Asp Ile Ala His Thr Pro Gly Val Ala Ala Asp Leu Ser His
            100                 105                 110
Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr Leu Gly Pro Glu Gln Leu
        115                 120                 125
Pro Asp Cys Leu Lys Xaa Cys Asp Val Val Val Ile Pro Ala Gly Val
    130                 135                 140
Pro Arg Lys Pro Gly Met Thr Arg Asp Asp Leu Phe Asn Thr Asn Ala
145                 150                 155                 160
Thr Ile Val Ala Thr Leu Thr Ala Ala Cys Ala Gln His Cys Pro Glu
                165                 170                 175
Ala Met Ile Cys Val Ile Ala Asn Pro Val Asn Ser Thr Ile Pro Ile
            180                 185                 190
Thr Ala Glu Val Phe Lys Lys His Gly Val Tyr Asn Pro Asn Lys Ile
        195                 200                 205
Phe Gly Val Thr Thr Leu Asp Ile Val Arg Ala Asn Thr Phe Val Ala
    210                 215                 220
Glu Leu Lys Gly Leu Asp Pro Ala Arg Val Asn Val Pro Val Ile Gly
225                 230                 235                 240
Gly His Ala Gly Lys Thr Ile Ile Pro Leu Ile Ser Gln Cys Thr Pro
                245                 250                 255
Lys Val Asp Phe Pro Gln Asp Gln Leu Thr Ala Leu Thr Gly Arg Ile
            260                 265                 270
Gln Glu Ala Gly Thr Glu Val Val Lys Ala Lys Ala Gly Ala Gly Ser
        275                 280                 285
Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala Arg Phe Val Phe Ser Leu
    290                 295                 300
Val Asp Ala Met Asn Gly Lys Glu Gly Val Val Glu Cys Ser Phe Val
305                 310                 315                 320
Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe Ser Thr Pro Leu Leu Leu
                325                 330                 335
Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly Ile Gly Lys Val Ser Ser
            340                 345                 350
Phe Glu Glu Lys Met Ile Ser Asp Ala Ile Pro Glu Leu Lys Ala Ser
        355                 360                 365
Ile Lys Lys Gly Glu Asp Phe Val Lys Thr Leu Lys
    370                 375                 380

<210> 477
<211> 338
<212> PRT
<213> Homo sapiens

<400> 477
Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser
 1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
            20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
        35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
    50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
            100                 105                 110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
        115                 120                 125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
    130                 135                 140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
145                 150                 155                 160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                165                 170                 175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
            180                 185                 190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
        195                 200                 205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
    210                 215                 220
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
225                 230                 235                 240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                245                 250                 255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
            260                 265                 270
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
        275                 280                 285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
    290                 295                 300
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
305                 310                 315                 320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                325                 330                 335
Leu Lys


<210> 478
<211> 77
<212> PRT
<213> Homo sapiens

<400> 478
Asn Asn Ala Lys Val Ala Val Leu Gly Ala Ser Gly Gly Ile Gly Gln
 1               5                  10                  15
Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro Leu Val Ser Arg Leu Thr
            20                  25                  30
Leu Tyr Asp Ile Ala His Thr Pro Gly Val Ala Ala Asp Leu Ser His
        35                  40                  45
Ile Glu Thr Lys Ala Ala Val Lys Gly Thr Gly Arg Ala Asp Pro Gly
    50                  55                  60
Asp Leu Leu Pro Val Pro Ser Arg Pro Gly Phe Glu Phe
65                  70                  75

<210> 479
<211> 77
<212> PRT
<213> Homo sapiens

<400> 479
Asn Asn Ala Lys Val Ala Val Leu Gly Ala Ser Gly Gly Ile Gly Gln
 1               5                  10                  15
Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro Leu Val Ser Arg Leu Thr
            20                  25                  30
Leu Tyr Asp Ile Ala His Thr Pro Gly Val Ala Ala Asp Leu Ser His
        35                  40                  45
Ile Glu Thr Lys Ala Ala Val Lys Gly Thr Gly Arg Ala Asp Pro Gly
    50                  55                  60
Asp Leu Leu Pro Val Pro Ser Arg Pro Gly Phe Glu Phe
65                  70                  75

<210> 480
<211> 77
<212> PRT
<213> Homo sapiens

<400> 480
Asn Asn Ala Lys Val Ala Val Leu Gly Ala Ser Gly Gly Ile Gly Gln
 1               5                  10                  15
Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro Leu Val Ser Arg Leu Thr
            20                  25                  30
Leu Tyr Asp Ile Ala His Thr Pro Gly Val Ala Ala Asp Leu Ser His
        35                  40                  45
Ile Glu Thr Lys Ala Ala Val Lys Gly Thr Gly Arg Ala Asp Pro Gly
    50                  55                  60
Asp Leu Leu Pro Val Pro Ser Arg Pro Gly Phe Glu Phe
65                  70                  75

<210> 481
<211> 77
<212> PRT
<213> Homo sapiens

<400> 481
Asn Asn Ala Lys Val Ala Val Leu Gly Ala Ser Gly Gly Ile Gly Gln
 1               5                  10                  15
Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro Leu Val Ser Arg Leu Thr
            20                  25                  30
Leu Tyr Asp Ile Ala His Thr Pro Gly Val Ala Ala Asp Leu Ser His
        35                  40                  45
Ile Glu Thr Lys Ala Ala Val Lys Gly Thr Gly Arg Ala Asp Pro Gly
    50                  55                  60
Asp Leu Leu Pro Val Pro Ser Arg Pro Gly Phe Glu Phe
65                  70                  75

<210> 482
<211> 338
<212> PRT
<213> Homo sapiens

<400> 482
Met Leu Ser Ala Leu Ala Arg Pro Val Ser Ala Ala Leu Arg Arg Ser
 1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
            20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
        35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
    50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
            100                 105                 110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
        115                 120                 125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
    130                 135                 140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
145                 150                 155                 160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                165                 170                 175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
            180                 185                 190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
        195                 200                 205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
    210                 215                 220
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
225                 230                 235                 240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                245                 250                 255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
            260                 265                 270
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
        275                 280                 285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
    290                 295                 300
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
305                 310                 315                 320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                325                 330                 335
Leu Lys


<210> 483
<211> 374
<212> PRT
<213> Homo sapiens

<400> 483
Ser Arg Glu Ala Pro Glu Ser Arg Arg Trp Ala Val Trp Arg Ser Leu
 1               5                  10                  15
Glu Ser Leu Pro Arg His Gln Leu Leu Cys Leu Pro Val Gly Ala Pro
            20                  25                  30
Pro Ala Pro Ala Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala
        35                  40                  45
Leu Arg Arg Ser Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala
    50                  55                  60
Val Leu Gly Ala Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu
65                  70                  75                  80
Lys Asn Ser Pro Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His
                85                  90                  95
Thr Pro Gly Val Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala
            100                 105                 110
Val Lys Gly Tyr Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly
        115                 120                 125
Cys Asp Val Val Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met
    130                 135                 140
Thr Arg Asp Asp Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu
145                 150                 155                 160
Thr Ala Ala Cys Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile
                165                 170                 175
Ala Asn Pro Val Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys
            180                 185                 190
Lys His Gly Val Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu
        195                 200                 205
Asp Ile Val Arg Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp
    210                 215                 220
Pro Ala Arg Val Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr
225                 230                 235                 240
Ile Ile Pro Leu Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln
                245                 250                 255
Asp Gln Leu Thr Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu
            260                 265                 270
Val Val Lys Ala Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala
        275                 280                 285
Tyr Ala Gly Ala Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly
    290                 295                 300
Lys Glu Gly Val Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu
305                 310                 315                 320
Cys Thr Tyr Phe Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu
                325                 330                 335
Lys Asn Leu Gly Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile
            340                 345                 350
Ser Asp Ala Ile Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp
        355                 360                 365
Phe Val Lys Thr Leu Lys
    370

<210> 484
<211> 338
<212> PRT
<213> Homo sapiens

<400> 484
Met Leu Ser Ala Leu Ala Arg Pro Val Ser Ala Ala Leu Arg Arg Ser
 1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
            20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
        35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
    50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
            100                 105                 110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
        115                 120                 125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
    130                 135                 140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
145                 150                 155                 160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                165                 170                 175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
            180                 185                 190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
        195                 200                 205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
    210                 215                 220
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
225                 230                 235                 240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                245                 250                 255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
            260                 265                 270
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
        275                 280                 285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
    290                 295                 300
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
305                 310                 315                 320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                325                 330                 335
Leu Lys


<210> 485
<211> 338
<212> PRT
<213> Homo sapiens

<400> 485
Met Leu Ser Ala Leu Ala Arg Pro Val Ser Ala Ala Leu Arg Arg Ser
 1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
            20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
        35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
    50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
            100                 105                 110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
        115                 120                 125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
    130                 135                 140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
145                 150                 155                 160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                165                 170                 175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
            180                 185                 190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
        195                 200                 205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
    210                 215                 220
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
225                 230                 235                 240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                245                 250                 255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
            260                 265                 270
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
        275                 280                 285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
    290                 295                 300
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
305                 310                 315                 320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                325                 330                 335
Leu Lys


<210> 486
<211> 261
<212> PRT
<213> Homo sapiens

<400> 486
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala
                85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser
            100                 105                 110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile
        115                 120                 125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe
    130                 135                 140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile
145                 150                 155                 160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly
                165                 170                 175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu
            180                 185                 190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala
        195                 200                 205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr
    210                 215                 220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys
225                 230                 235                 240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu
                245                 250                 255
Asp Glu Glu Gly Ser
            260

<210> 487
<211> 261
<212> PRT
<213> Homo sapiens

<400> 487
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala
                85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser
            100                 105                 110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile
        115                 120                 125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe
    130                 135                 140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile
145                 150                 155                 160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly
                165                 170                 175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu
            180                 185                 190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala
        195                 200                 205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr
    210                 215                 220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys
225                 230                 235                 240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu
                245                 250                 255
Asp Glu Glu Gly Ser
            260

<210> 488
<211> 261
<212> PRT
<213> Homo sapiens

<400> 488
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala
                85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser
            100                 105                 110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile
        115                 120                 125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe
    130                 135                 140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile
145                 150                 155                 160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly
                165                 170                 175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu
            180                 185                 190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala
        195                 200                 205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr
    210                 215                 220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys
225                 230                 235                 240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu
                245                 250                 255
Asp Glu Glu Gly Ser
            260

<210> 489
<211> 261
<212> PRT
<213> Homo sapiens

<400> 489
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala
                85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser
            100                 105                 110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile
        115                 120                 125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe
    130                 135                 140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile
145                 150                 155                 160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly
                165                 170                 175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu
            180                 185                 190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala
        195                 200                 205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr
    210                 215                 220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys
225                 230                 235                 240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu
                245                 250                 255
Asp Glu Glu Gly Ser
            260

<210> 490
<211> 269
<212> PRT
<213> Homo sapiens

<400> 490
Arg Arg Cys Cys His Ser Ala Thr Met Phe Glu Ala Arg Leu Val Gln
 1               5                  10                  15
Gly Ser Ile Leu Lys Lys Val Leu Glu Ala Leu Lys Asp Leu Ile Asn
            20                  25                  30
Glu Ala Cys Trp Asp Ile Ser Ser Ser Gly Val Asn Leu Gln Ser Met
        35                  40                  45
Asp Ser Ser His Val Ser Leu Val Gln Leu Thr Leu Arg Ser Glu Gly
    50                  55                  60
Phe Asp Thr Tyr Arg Cys Asp Arg Asn Leu Ala Met Gly Val Asn Leu
65                  70                  75                  80
Thr Ser Met Ser Lys Ile Leu Lys Cys Ala Gly Asn Glu Asp Ile Ile
                85                  90                  95
Thr Leu Arg Ala Glu Asp Asn Ala Asp Thr Leu Ala Leu Val Phe Glu
            100                 105                 110
Ala Pro Asn Gln Glu Lys Val Ser Asp Tyr Glu Met Lys Leu Met Asp
        115                 120                 125
Leu Asp Val Glu Gln Leu Gly Ile Pro Glu Gln Glu Tyr Ser Cys Val
    130                 135                 140
Val Lys Met Pro Ser Gly Glu Phe Ala Arg Ile Cys Arg Asp Leu Ser
145                 150                 155                 160
His Ile Gly Asp Ala Val Val Ile Ser Cys Ala Lys Asp Gly Val Lys
                165                 170                 175
Phe Ser Ala Ser Gly Glu Leu Gly Asn Gly Asn Ile Lys Leu Ser Gln
            180                 185                 190
Thr Ser Asn Val Asp Lys Glu Glu Glu Ala Val Thr Ile Glu Met Asn
        195                 200                 205
Glu Pro Val Gln Leu Thr Phe Ala Leu Arg Tyr Leu Asn Phe Phe Thr
    210                 215                 220
Lys Ala Thr Pro Leu Ser Ser Thr Val Thr Leu Ser Met Ser Ala Asp
225                 230                 235                 240
Val Pro Leu Val Val Glu Tyr Lys Ile Ala Asp Met Gly His Leu Lys
                245                 250                 255
Tyr Tyr Leu Ala Pro Lys Ile Glu Asp Glu Glu Gly Ser
            260                 265

<210> 491
<211> 268
<212> PRT
<213> Homo sapiens

<400> 491
Arg Arg Cys Cys His Ser Ala Thr Met Phe Glu Ala Arg Leu Val Gln
 1               5                  10                  15
Gly Ser Ile Leu Lys Lys Val Leu Glu Ala Leu Lys Asp Leu Ile Asn
            20                  25                  30
Glu Ala Cys Trp Asp Ile Ser Ser Ser Gly Val Asn Leu Gln Ser Met
        35                  40                  45
Asp Ser Ser His Val Ser Leu Val Gln Leu Thr Leu Arg Ser Glu Gly
    50                  55                  60
Phe Asp Thr Tyr Arg Cys Asp Arg Asn Leu Ala Met Gly Val Asn Leu
65                  70                  75                  80
Thr Ser Met Ser Lys Ile Leu Lys Cys Ala Gly Asn Glu Asp Ile Ile
                85                  90                  95
Thr Leu Arg Ala Glu Asp Asn Ala Asp Thr Leu Ala Leu Val Phe Glu
            100                 105                 110
Ala Pro Asn Gln Glu Lys Val Ser Asp Tyr Glu Met Lys Leu Met Asp
        115                 120                 125
Leu Asp Val Glu Gln Leu Gly Ile Pro Glu Gln Glu Tyr Ser Cys Val
    130                 135                 140
Val Lys Met Pro Ser Gly Glu Phe Ala Arg Ile Cys Arg Asp Leu Ser
145                 150                 155                 160
His Ile Gly Asp Ala Val Val Ile Ser Cys Ala Lys Asp Gly Val Lys
                165                 170                 175
Phe Ser Ala Ser Gly Glu Leu Gly Asn Gly Asn Ile Lys Leu Ser Gln
            180                 185                 190
Thr Ser Asn Val Asp Lys Glu Glu Glu Ala Val Thr Ile Glu Met Asn
        195                 200                 205
Glu Pro Val Gln Leu Thr Phe Ala Leu Arg Tyr Leu Asn Phe Phe Thr
    210                 215                 220
Lys Ala Thr Pro Leu Ser Ser Thr Val Thr Leu Ser Met Ser Ala Asp
225                 230                 235                 240
Val Pro Leu Val Val Glu Tyr Lys Ile Ala Asp Met Gly His Leu Lys
                245                 250                 255
Tyr Tyr Leu Ala Pro Lys Ile Glu Asp Glu Gly Ser
            260                 265

<210> 492
<211> 301
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(301)
<223> Xaa = Any Amino Acid

<400> 492
Thr Phe Leu Leu Pro Ala Cys Leu Leu Ala Ala Leu Leu Pro Leu Arg
 1               5                  10                  15
His His Val Arg Gly Arg Ala Trp Val Gln Gly Ser Ile Leu Asn Glu
            20                  25                  30
Gly Val Gly Xaa Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Gly
        35                  40                  45
Tyr Xaa Ala Pro Ala Gly Val Asn Leu Gln Ser Met Gly His Arg Pro
    50                  55                  60
Thr Val Ser Leu Val Gln Leu Thr Leu Arg Val Xaa Gly Ala Ser Thr
65                  70                  75                  80
Pro Tyr Arg Cys Asp Arg Asn Leu Gly His Gly Arg Xaa Asn Leu Thr
                85                  90                  95
Ser Met Ser Lys Ile Leu Lys Met Ala Ala Gly Asn Glu Asp Ile Ser
            100                 105                 110
Leu Thr Leu Arg Ala Glu Asp Asn Ala Gly Tyr Leu Gly Arg Xaa Tyr
        115                 120                 125
Phe Glu Gly Thr Lys Pro Gly Arg Lys Phe Ser Asp Tyr Glu Met Lys
    130                 135                 140
Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile Pro Glu Gln Glu Tyr
145                 150                 155                 160
Ser Cys Val Val Lys Met Pro Ser Gly Glu Tyr Ala Arg Ile Cys Arg
                165                 170                 175
Glu Ser Gln Pro Ile Leu Gly Asp Ala Val Val Ile Ser Cys Ala Lys
            180                 185                 190
Asp Gly Ser Glu Asn Phe Ser Ala Ser Gly Glu Leu Gly Asn Glu Thr
        195                 200                 205
Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu Glu Ala Val
    210                 215                 220
Pro Ile Lys Met Asn Glu Pro Val Gln Pro Asn Phe Cys His Xaa Gly
225                 230                 235                 240
Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr Val Asp
                245                 250                 255
Thr Pro Val Cys Ser Ala Asp Gly Thr Pro Leu Val Gly Arg Ser Ile
            260                 265                 270
Lys Ile Ala Gly Tyr Gly Asp His Leu Lys Tyr Leu Leu Gly Leu Pro
        275                 280                 285
Lys Asp Pro Arg Ile Glu Glu Gly Ser Leu Gly His Ser
    290                 295                 300

<210> 493
<211> 236
<212> PRT
<213> Homo sapiens

<400> 493
Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser Ser Gly Val Asn Leu
 1               5                  10                  15
Gln Ser Met Asp Ser Ser His Val Ser Leu Val Gln Leu Thr Leu Arg
            20                  25                  30
Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg Asn Leu Ala Met Gly
        35                  40                  45
Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys Cys Ala Gly Asn Glu
    50                  55                  60
Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala Asp Thr Leu Ala Leu
65                  70                  75                  80
Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser Asp Tyr Glu Met Lys
                85                  90                  95
Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile Pro Glu Gln Glu Tyr
            100                 105                 110
Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe Ala Arg Ile Cys Arg
        115                 120                 125
Asp Leu Ser His Ile Gly Asp Ala Val Val Ile Ser Cys Ala Lys Asp
    130                 135                 140
Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly Asn Gly Asn Ile Lys
145                 150                 155                 160
Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu Glu Ala Val Thr Ile
                165                 170                 175
Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala Leu Arg Tyr Leu Asn
            180                 185                 190
Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr Val Thr Leu Ser Met
        195                 200                 205
Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys Ile Ala Asp Met Gly
    210                 215                 220
His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu Asp
225                 230                 235

<210> 494
<211> 261
<212> PRT
<213> Homo sapiens

<400> 494
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala
                85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser
            100                 105                 110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile
        115                 120                 125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe
    130                 135                 140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile
145                 150                 155                 160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly
                165                 170                 175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu
            180                 185                 190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala
        195                 200                 205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr
    210                 215                 220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys
225                 230                 235                 240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu
                245                 250                 255
Asp Glu Glu Gly Ser
            260

<210> 495
<211> 261
<212> PRT
<213> Homo sapiens

<400> 495
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala
                85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser
            100                 105                 110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile
        115                 120                 125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe
    130                 135                 140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile
145                 150                 155                 160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly
                165                 170                 175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu
            180                 185                 190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala
        195                 200                 205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr
    210                 215                 220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys
225                 230                 235                 240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu
                245                 250                 255
Asp Glu Glu Gly Ser
            260

<210> 496
<211> 261
<212> PRT
<213> Homo sapiens

<400> 496
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala
                85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser
            100                 105                 110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile
        115                 120                 125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe
    130                 135                 140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile
145                 150                 155                 160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly
                165                 170                 175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu
            180                 185                 190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala
        195                 200                 205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr
    210                 215                 220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys
225                 230                 235                 240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu
                245                 250                 255
Asp Glu Glu Gly Ser
            260

<210> 497
<211> 261
<212> PRT
<213> Homo sapiens

<400> 497
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala
                85                  90                  95
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser
            100                 105                 110
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile
        115                 120                 125
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe
    130                 135                 140
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile
145                 150                 155                 160
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly
                165                 170                 175
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu
            180                 185                 190
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala
        195                 200                 205
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr
    210                 215                 220
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys
225                 230                 235                 240
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu
                245                 250                 255
Asp Glu Glu Gly Ser
            260

<210> 498
<211> 529
<212> PRT
<213> Homo sapiens

<400> 498
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 499
<211> 529
<212> PRT
<213> Homo sapiens

<400> 499
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 500
<211> 529
<212> PRT
<213> Homo sapiens

<400> 500
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Pro Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 501
<211> 529
<212> PRT
<213> Homo sapiens

<400> 501
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Phe Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Glu
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 502
<211> 529
<212> PRT
<213> Homo sapiens

<400> 502
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Glu Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Pro Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Asp Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Gly Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Pro Gln His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Leu Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Pro Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Pro Glu Leu Gly Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 503
<211> 529
<212> PRT
<213> Homo sapiens

<400> 503
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 504
<211> 529
<212> PRT
<213> Homo sapiens

<400> 504
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 505
<211> 529
<212> PRT
<213> Homo sapiens

<400> 505
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 506
<211> 529
<212> PRT
<213> Homo sapiens

<400> 506
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 507
<211> 626
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(626)
<223> Xaa = Any Amino Acid

<400> 507
Arg Gly Val Trp Gly Gly His Val Pro Gly Gly Ser Arg Glu Glu Trp
 1               5                  10                  15
Ser Gly Glu Asp Gln Gly Gly Lys Arg Arg Gly Asp Ala Val Ala Glu
            20                  25                  30
Asn Cys Ala Glu Ala Arg Glu Ala Gly Glu Ser Val Leu Gly Pro Arg
        35                  40                  45
Val Gln Val Gly Val Glu Pro Pro Ser Asp Arg Lys Leu Arg Arg Val
    50                  55                  60
Ala Gly Ser Ala Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys
65                  70                  75                  80
Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala
                85                  90                  95
Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu
            100                 105                 110
Val Lys Glu Ile Phe Pro Gln Lys Lys Lys Gly Gly Gly Ser Ala Glu
        115                 120                 125
Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser Lys
    130                 135                 140
Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr Arg
145                 150                 155                 160
Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu Ala
                165                 170                 175
Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Lys Leu Pro
            180                 185                 190
Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Glu Pro
        195                 200                 205
Leu Arg Pro Phe Gln Gly Gln Arg Arg Gly Ala Asn Leu Ala Gly Ser
    210                 215                 220
Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu
225                 230                 235                 240
Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr
                245                 250                 255
Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Arg
            260                 265                 270
Ser Leu Leu His Ser Val Lys Thr Lys Asn Leu Arg Gly Ile Leu Asp
        275                 280                 285
Leu Thr Pro Asn Tyr Arg Gly Xaa Glu Leu Arg Trp Phe Ser Thr Gln
    290                 295                 300
Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu
305                 310                 315                 320
Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys
                325                 330                 335
Asp Ala Ser Ser Ile Leu Gly Leu Ser Trp Gln Asn Ile Ser Pro Lys
            340                 345                 350
Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp
        355                 360                 365
Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu
    370                 375                 380
Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys
385                 390                 395                 400
Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser
                405                 410                 415
Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln
            420                 425                 430
Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro
        435                 440                 445
Val Phe Gln Ala Thr Gly Asn Glu Ile Gly Leu Gly Cys Ser Cys Pro
    450                 455                 460
Leu Leu Gly Gln Pro Met Gly Gly Ser Gln Phe Met Leu Trp Asp Glu
465                 470                 475                 480
Val Pro Ala Phe Pro Asp Ile Pro Gly Gly Cys Xaa Val Ala Asn Met
                485                 490                 495
Asp Cys Gly Arg Gly Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu
            500                 505                 510
Phe Arg Arg Leu Asn Asp Gln Arg Ser Lys Glu Ala Pro Pro Tyr Cys
        515                 520                 525
His Gly Asp Phe His Ala Phe Leu Pro Leu Gly Pro Trp Thr Leu Ser
    530                 535                 540
Pro Ile Ile Arg Gln Leu Gly Thr Gln Asn Glu Thr Phe Ser Gly Xaa
545                 550                 555                 560
Cys Leu Asn Leu Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
                565                 570                 575
Asp Leu Pro Ala Ser Ala Lys Pro Trp Pro Ala Lys Ala Asp Leu Leu
            580                 585                 590
Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu
        595                 600                 605
Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr
    610                 615                 620
Ala Ala
625

<210> 508
<211> 529
<212> PRT
<213> Homo sapiens

<400> 508
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 509
<211> 529
<212> PRT
<213> Homo sapiens

<400> 509
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Glu Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Pro Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Asp Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Gly Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Pro Gln His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Leu Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Pro Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Pro Glu Leu Gly Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 510
<211> 529
<212> PRT
<213> Homo sapiens

<400> 510
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525
Ala


<210> 511
<211> 683
<212> PRT
<213> Homo sapiens

<400> 511
Met Ser Ser Glu Ser Ser Lys Lys Arg Lys Pro Lys Val Ile Arg Ser
 1               5                  10                  15
Asp Gly Ala Pro Ala Glu Gly Lys Arg Asn Arg Ser Asp Thr Glu Gln
            20                  25                  30
Glu Gly Lys Tyr Tyr Ser Glu Glu Ala Glu Val Asp Leu Arg Asp Pro
        35                  40                  45
Gly Arg Asp Tyr Glu Leu Tyr Lys Tyr Thr Cys Gln Glu Leu Gln Arg
    50                  55                  60
Leu Met Ala Glu Ile Gln Asp Leu Lys Ser Arg Gly Gly Lys Asp Val
65                  70                  75                  80
Ala Ile Glu Ile Glu Glu Arg Arg Ile Gln Ser Cys Val His Phe Met
                85                  90                  95
Thr Leu Lys Lys Leu Asn Arg Leu Ala His Ile Arg Leu Lys Lys Gly
            100                 105                 110
Arg Asp Gln Thr His Glu Ala Lys Gln Lys Val Asp Ala Tyr His Leu
        115                 120                 125
Gln Leu Gln Asn Leu Leu Tyr Glu Val Met His Leu Gln Lys Glu Ile
    130                 135                 140
Thr Lys Cys Leu Glu Phe Lys Ser Lys His Glu Glu Ile Asp Leu Val
145                 150                 155                 160
Ser Leu Glu Glu Phe Tyr Lys Glu Ala Pro Pro Asp Ile Ser Lys Ala
                165                 170                 175
Glu Val Thr Met Gly Asp Pro His Gln Gln Thr Leu Ala Arg Leu Asp
            180                 185                 190
Trp Glu Leu Glu Gln Arg Lys Arg Leu Ala Glu Lys Tyr Arg Glu Cys
        195                 200                 205
Leu Ser Asn Lys Glu Lys Ile Leu Lys Glu Ile Glu Val Lys Lys Glu
    210                 215                 220
Tyr Leu Ser Ser Leu Gln Pro Arg Leu Asn Ser Ile Met Gln Ala Ser
225                 230                 235                 240
Leu Pro Val Gln Glu Tyr Leu Phe Met Pro Phe Asp Gln Ala His Lys
                245                 250                 255
Gln Tyr Glu Thr Ala Arg His Leu Pro Pro Pro Leu Tyr Val Leu Phe
            260                 265                 270
Val Gln Ala Thr Ala Tyr Gly Gln Ala Cys Asp Lys Thr Leu Ser Val
        275                 280                 285
Ala Ile Glu Gly Ser Val Asp Glu Ala Lys Ala Leu Phe Lys Pro Pro
    290                 295                 300
Glu Asp Ser Gln Asp Asp Glu Ser Asp Ser Asp Ala Glu Glu Glu Gln
305                 310                 315                 320
Thr Thr Lys Arg Arg Arg Pro Thr Leu Gly Val Gln Leu Asp Asp Lys
                325                 330                 335
Arg Lys Glu Met Leu Lys Arg His Pro Leu Ser Val Met Leu Asp Leu
            340                 345                 350
Lys Cys Lys Asp Asp Ser Val Leu His Leu Thr Phe Tyr Tyr Leu Met
        355                 360                 365
Asn Leu Asn Ile Met Thr Val Lys Ala Lys Val Thr Thr Ala Met Glu
    370                 375                 380
Leu Ile Thr Pro Ile Ser Ala Gly Asp Leu Leu Ser Pro Asp Ser Val
385                 390                 395                 400
Leu Ser Cys Leu Tyr Pro Gly Asp His Gly Lys Lys Thr Pro Asn Pro
                405                 410                 415
Ala Asn Gln Tyr Gln Phe Asp Lys Val Gly Ile Leu Thr Leu Ser Asp
            420                 425                 430
Tyr Val Leu Glu Leu Gly His Pro Tyr Leu Trp Val Gln Lys Leu Gly
        435                 440                 445
Gly Leu His Phe Pro Lys Glu Gln Pro Gln Gln Thr Val Ile Ala Asp
    450                 455                 460
His Ser Leu Ser Ala Ser His Met Glu Thr Thr Met Lys Leu Leu Lys
465                 470                 475                 480
Thr Arg Val Gln Ser Arg Leu Ala Leu His Lys Gln Phe Ala Ser Leu
                485                 490                 495
Glu His Gly Ile Val Pro Val Thr Ser Asp Cys Gln Tyr Leu Phe Pro
            500                 505                 510
Ala Lys Val Val Ser Arg Leu Val Lys Trp Val Thr Ile Ala His Glu
        515                 520                 525
Asp Tyr Met Glu Leu His Phe Thr Lys Asp Ile Val Asp Ala Gly Leu
    530                 535                 540
Ala Gly Asp Thr Asn Leu Tyr Tyr Met Ala Leu Ile Glu Arg Gly Thr
545                 550                 555                 560
Ala Lys Leu Gln Ala Ala Val Val Leu Asn Pro Gly Tyr Ser Ser Ile
                565                 570                 575
Pro Pro Ile Phe Gln Leu Cys Leu Asn Trp Lys Gly Glu Lys Thr Asn
            580                 585                 590
Ser Asn Asp Asp Asn Ile Arg Ala Met Glu Gly Glu Val Asn Val Cys
        595                 600                 605
Tyr Lys Glu Leu Cys Gly Pro Trp Pro Ser His Gln Leu Leu Thr Asn
    610                 615                 620
Gln Leu Gln Arg Leu Cys Val Leu Leu Asp Val Tyr Leu Glu Thr Glu
625                 630                 635                 640
Ser His Asp Asp Ser Val Glu Gly Pro Lys Glu Phe Pro Gln Glu Lys
                645                 650                 655
Met Cys Leu Arg Leu Phe Arg Gly Pro Ser Arg Met Lys Pro Phe Lys
            660                 665                 670
Tyr Asn His Pro Gln Gly Phe Phe Ser His Arg
        675                 680

<210> 512
<211> 683
<212> PRT
<213> Homo sapiens

<400> 512
Met Ser Ser Glu Ser Ser Lys Lys Arg Lys Pro Lys Val Ile Arg Ser
 1               5                  10                  15
Asp Gly Ala Pro Ala Glu Gly Lys Arg Asn Arg Ser Asp Thr Glu Gln
            20                  25                  30
Glu Gly Lys Tyr Tyr Ser Glu Glu Ala Glu Val Asp Leu Arg Asp Pro
        35                  40                  45
Gly Arg Asp Tyr Glu Leu Tyr Lys Tyr Thr Cys Gln Glu Leu Gln Arg
    50                  55                  60
Leu Met Ala Glu Ile Gln Asp Leu Lys Ser Arg Gly Gly Lys Asp Val
65                  70                  75                  80
Ala Ile Glu Ile Glu Glu Arg Arg Ile Gln Ser Cys Val His Phe Met
                85                  90                  95
Thr Leu Lys Lys Leu Asn Arg Leu Ala His Ile Arg Leu Lys Lys Gly
            100                 105                 110
Arg Asp Gln Thr His Glu Ala Lys Gln Lys Val Asp Ala Tyr His Leu
        115                 120                 125
Gln Leu Gln Asn Leu Leu Tyr Glu Val Met His Leu Gln Lys Glu Ile
    130                 135                 140
Thr Lys Cys Leu Glu Phe Lys Ser Lys His Glu Glu Ile Asp Leu Val
145                 150                 155                 160
Ser Leu Glu Glu Phe Tyr Lys Glu Ala Pro Pro Asp Ile Ser Lys Ala
                165                 170                 175
Glu Val Thr Met Gly Asp Pro His Gln Gln Thr Leu Ala Arg Leu Asp
            180                 185                 190
Trp Glu Leu Glu Gln Arg Lys Arg Leu Ala Glu Lys Tyr Arg Glu Cys
        195                 200                 205
Leu Ser Asn Lys Glu Lys Ile Leu Lys Glu Ile Glu Val Lys Lys Glu
    210                 215                 220
Tyr Leu Ser Ser Leu Gln Pro Arg Leu Asn Ser Ile Met Gln Ala Ser
225                 230                 235                 240
Leu Pro Val Gln Glu Tyr Leu Phe Met Pro Phe Asp Gln Ala His Lys
                245                 250                 255
Gln Tyr Glu Thr Ala Arg His Leu Pro Pro Pro Leu Tyr Val Leu Phe
            260                 265                 270
Val Gln Ala Thr Ala Tyr Gly Gln Ala Cys Asp Lys Thr Leu Ser Val
        275                 280                 285
Ala Ile Glu Gly Ser Val Asp Glu Ala Lys Ala Leu Phe Lys Pro Pro
    290                 295                 300
Glu Asp Ser Gln Asp Asp Glu Ser Asp Ser Asp Ala Glu Glu Glu Gln
305                 310                 315                 320
Thr Thr Lys Arg Arg Arg Pro Thr Leu Gly Val Gln Leu Asp Asp Lys
                325                 330                 335
Arg Lys Glu Met Leu Lys Arg His Pro Leu Ser Val Met Leu Asp Leu
            340                 345                 350
Lys Cys Lys Asp Asp Ser Val Leu His Leu Thr Phe Tyr Tyr Leu Met
        355                 360                 365
Asn Leu Asn Ile Met Thr Val Lys Ala Lys Val Thr Thr Ala Met Glu
    370                 375                 380
Leu Ile Thr Pro Ile Ser Ala Gly Asp Leu Leu Ser Pro Asp Ser Val
385                 390                 395                 400
Leu Ser Cys Leu Tyr Pro Gly Asp His Gly Lys Lys Thr Pro Asn Pro
                405                 410                 415
Ala Asn Gln Tyr Gln Phe Asp Lys Val Gly Ile Leu Thr Leu Ser Asp
            420                 425                 430
Tyr Val Leu Glu Leu Gly His Pro Tyr Leu Trp Val Gln Lys Leu Gly
        435                 440                 445
Gly Leu His Phe Pro Lys Glu Gln Pro Gln Gln Thr Val Ile Ala Asp
    450                 455                 460
His Ser Leu Ser Ala Ser His Met Glu Thr Thr Met Lys Leu Leu Lys
465                 470                 475                 480
Thr Arg Val Gln Ser Arg Leu Ala Leu His Lys Gln Phe Ala Ser Leu
                485                 490                 495
Glu His Gly Ile Val Pro Val Thr Ser Asp Cys Gln Tyr Leu Phe Pro
            500                 505                 510
Ala Lys Val Val Ser Arg Leu Val Lys Trp Val Thr Ile Ala His Glu
        515                 520                 525
Asp Tyr Met Glu Leu His Phe Thr Lys Asp Ile Val Asp Ala Gly Leu
    530                 535                 540
Ala Gly Asp Thr Asn Leu Tyr Tyr Met Ala Leu Ile Glu Arg Gly Thr
545                 550                 555                 560
Ala Lys Leu Gln Ala Ala Val Val Leu Asn Pro Gly Tyr Ser Ser Ile
                565                 570                 575
Pro Pro Ile Phe Gln Leu Cys Leu Asn Trp Lys Gly Glu Lys Thr Asn
            580                 585                 590
Ser Asn Asp Asp Asn Ile Arg Ala Met Glu Gly Glu Val Asn Val Cys
        595                 600                 605
Tyr Lys Glu Leu Cys Gly Pro Trp Pro Ser His Gln Leu Leu Thr Asn
    610                 615                 620
Gln Leu Gln Arg Leu Cys Val Leu Leu Asp Val Tyr Leu Glu Thr Glu
625                 630                 635                 640
Ser His Asp Asp Ser Val Glu Gly Pro Lys Glu Phe Pro Gln Glu Lys
                645                 650                 655
Met Cys Leu Arg Leu Phe Arg Gly Pro Ser Arg Met Lys Pro Phe Lys
            660                 665                 670
Tyr Asn His Pro Gln Gly Phe Phe Ser His Arg
        675                 680

<210> 513
<211> 683
<212> PRT
<213> Homo sapiens

<400> 513
Met Ser Ser Glu Ser Ser Lys Lys Arg Lys Pro Lys Val Ile Arg Ser
 1               5                  10                  15
Asp Gly Ala Pro Ala Glu Gly Lys Arg Asn Arg Ser Asp Thr Glu Gln
            20                  25                  30
Glu Gly Lys Tyr Tyr Ser Glu Glu Ala Glu Val Asp Leu Arg Asp Pro
        35                  40                  45
Gly Arg Asp Tyr Glu Leu Tyr Lys Tyr Thr Cys Gln Glu Leu Gln Arg
    50                  55                  60
Leu Met Ala Glu Ile Gln Asp Leu Lys Ser Arg Gly Gly Lys Asp Val
65                  70                  75                  80
Ala Ile Glu Ile Glu Glu Arg Arg Ile Gln Ser Cys Val His Phe Met
                85                  90                  95
Thr Leu Lys Lys Leu Asn Arg Leu Ala His Ile Arg Leu Lys Lys Gly
            100                 105                 110
Arg Asp Gln Thr His Glu Ala Lys Gln Lys Val Asp Ala Tyr His Leu
        115                 120                 125
Gln Leu Gln Asn Leu Leu Tyr Glu Val Met His Leu Gln Lys Glu Ile
    130                 135                 140
Thr Lys Cys Leu Glu Phe Lys Ser Lys His Glu Glu Ile Asp Leu Val
145                 150                 155                 160
Ser Leu Glu Glu Phe Tyr Lys Glu Ala Pro Pro Asp Ile Ser Lys Ala
                165                 170                 175
Glu Val Thr Met Gly Asp Pro His Gln Gln Thr Leu Ala Arg Leu Asp
            180                 185                 190
Trp Glu Leu Glu Gln Arg Lys Arg Leu Ala Glu Lys Tyr Arg Glu Cys
        195                 200                 205
Leu Ser Asn Lys Glu Lys Ile Leu Lys Glu Ile Glu Val Lys Lys Glu
    210                 215                 220
Tyr Leu Ser Ser Leu Gln Pro Arg Leu Asn Ser Ile Met Gln Ala Ser
225                 230                 235                 240
Leu Pro Val Gln Glu Tyr Leu Phe Met Pro Phe Asp Gln Ala His Lys
                245                 250                 255
Gln Tyr Glu Thr Ala Arg His Leu Pro Pro Pro Leu Tyr Val Leu Phe
            260                 265                 270
Val Gln Ala Thr Ala Tyr Gly Gln Ala Cys Asp Lys Thr Leu Ser Val
        275                 280                 285
Ala Ile Glu Gly Ser Val Asp Glu Ala Lys Ala Leu Phe Lys Pro Pro
    290                 295                 300
Glu Asp Ser Gln Asp Asp Glu Ser Asp Ser Asp Ala Glu Glu Glu Gln
305                 310                 315                 320
Thr Thr Lys Arg Arg Arg Pro Thr Leu Gly Val Gln Leu Asp Asp Lys
                325                 330                 335
Arg Lys Glu Met Leu Lys Arg His Pro Leu Ser Val Met Leu Asp Leu
            340                 345                 350
Lys Cys Lys Asp Asp Ser Val Leu His Leu Thr Phe Tyr Tyr Leu Met
        355                 360                 365
Asn Leu Asn Ile Met Thr Val Lys Ala Lys Val Thr Thr Ala Met Glu
    370                 375                 380
Leu Ile Thr Pro Ile Ser Ala Gly Asp Leu Leu Ser Pro Asp Ser Val
385                 390                 395                 400
Leu Ser Cys Leu Tyr Pro Gly Asp His Gly Lys Lys Thr Pro Asn Pro
                405                 410                 415
Ala Asn Gln Tyr Gln Phe Asp Lys Val Gly Ile Leu Thr Leu Ser Asp
            420                 425                 430
Tyr Val Leu Glu Leu Gly His Pro Tyr Leu Trp Val Gln Lys Leu Gly
        435                 440                 445
Gly Leu His Phe Pro Lys Glu Gln Pro Gln Gln Thr Val Ile Ala Asp
    450                 455                 460
His Ser Leu Ser Ala Ser His Met Glu Thr Thr Met Lys Leu Leu Lys
465                 470                 475                 480
Thr Arg Val Gln Ser Arg Leu Ala Leu His Lys Gln Phe Ala Ser Leu
                485                 490                 495
Glu His Gly Ile Val Pro Val Thr Ser Asp Cys Gln Tyr Leu Phe Pro
            500                 505                 510
Ala Lys Val Val Ser Arg Leu Val Lys Trp Val Thr Ile Ala His Glu
        515                 520                 525
Asp Tyr Met Glu Leu His Phe Thr Lys Asp Ile Val Asp Ala Gly Leu
    530                 535                 540
Ala Gly Asp Thr Asn Leu Tyr Tyr Met Ala Leu Ile Glu Arg Gly Thr
545                 550                 555                 560
Ala Lys Leu Gln Ala Ala Val Val Leu Asn Pro Gly Tyr Ser Ser Ile
                565                 570                 575
Pro Pro Val Phe Gln Leu Cys Leu Asn Trp Lys Gly Glu Lys Thr Asn
            580                 585                 590
Ser Asn Asp Asp Asn Ile Arg Ala Met Glu Gly Glu Val Asn Val Cys
        595                 600                 605
Tyr Lys Glu Leu Cys Gly Pro Trp Pro Ser His Gln Leu Leu Thr Asn
    610                 615                 620
Gln Leu Gln Arg Leu Cys Val Leu Leu Asp Val Tyr Leu Glu Thr Glu
625                 630                 635                 640
Ser His Asp Asp Ser Val Glu Gly Pro Lys Glu Phe Pro Gln Glu Lys
                645                 650                 655
Met Cys Leu Arg Leu Phe Arg Gly Pro Ser Arg Met Lys Pro Phe Lys
            660                 665                 670
Tyr Asn His Pro Gln Gly Phe Phe Ser His Arg
        675                 680

<210> 514
<211> 683
<212> PRT
<213> Homo sapiens

<400> 514
Met Ser Ser Glu Ser Ser Lys Lys Arg Lys Pro Lys Val Ile Arg Ser
 1               5                  10                  15
Asp Gly Ala Pro Ala Glu Gly Lys Arg Asn Arg Ser Asp Thr Glu Gln
            20                  25                  30
Glu Gly Lys Tyr Tyr Ser Glu Glu Ala Glu Val Asp Leu Arg Asp Pro
        35                  40                  45
Gly Arg Asp Tyr Glu Leu Tyr Lys Tyr Thr Cys Gln Glu Leu Gln Arg
    50                  55                  60
Leu Met Ala Glu Ile Gln Asp Leu Lys Ser Arg Gly Gly Lys Asp Val
65                  70                  75                  80
Ala Ile Glu Ile Glu Glu Arg Arg Ile Gln Ser Cys Val His Phe Met
                85                  90                  95
Thr Leu Lys Lys Leu Asn Arg Leu Ala His Ile Arg Leu Lys Lys Gly
            100                 105                 110
Arg Asp Gln Thr His Glu Ala Lys Gln Lys Val Asp Ala Tyr His Leu
        115                 120                 125
Gln Leu Gln Asn Leu Leu Tyr Glu Val Met His Leu Gln Lys Glu Ile
    130                 135                 140
Thr Lys Cys Leu Glu Phe Lys Ser Lys His Glu Glu Ile Asp Leu Val
145                 150                 155                 160
Ser Leu Glu Glu Phe Tyr Lys Glu Ala Pro Pro Asp Ile Ser Lys Ala
                165                 170                 175
Glu Val Thr Met Gly Asp Pro His Gln Gln Thr Leu Ala Arg Leu Asp
            180                 185                 190
Trp Glu Leu Glu Gln Arg Lys Arg Leu Ala Glu Lys Tyr Arg Glu Cys
        195                 200                 205
Leu Ser Asn Lys Glu Lys Ile Leu Lys Glu Ile Glu Val Lys Lys Glu
    210                 215                 220
Tyr Leu Ser Ser Leu Gln Pro Arg Leu Asn Ser Ile Met Gln Ala Ser
225                 230                 235                 240
Leu Pro Val Gln Glu Tyr Leu Phe Met Pro Phe Asp Gln Ala His Lys
                245                 250                 255
Gln Tyr Glu Thr Ala Arg His Leu Pro Pro Pro Leu Tyr Val Leu Phe
            260                 265                 270
Val Gln Ala Thr Ala Tyr Gly Gln Ala Cys Asp Lys Thr Leu Ser Val
        275                 280                 285
Ala Ile Glu Gly Ser Val Asp Glu Ala Lys Ala Leu Phe Lys Pro Pro
    290                 295                 300
Glu Asp Ser Gln Asp Asp Glu Ser Asp Ser Asp Ala Glu Glu Glu Gln
305                 310                 315                 320
Thr Thr Lys Arg Arg Arg Pro Thr Leu Gly Val Gln Leu Asp Asp Lys
                325                 330                 335
Arg Lys Glu Met Leu Lys Arg His Pro Leu Ser Val Met Leu Asp Leu
            340                 345                 350
Lys Cys Lys Asp Asp Ser Val Leu His Leu Thr Phe Tyr Tyr Leu Met
        355                 360                 365
Asn Leu Asn Ile Met Thr Val Lys Ala Lys Val Thr Thr Ala Met Glu
    370                 375                 380
Leu Ile Thr Pro Ile Ser Ala Gly Asp Leu Leu Ser Pro Asp Ser Val
385                 390                 395                 400
Leu Ser Cys Leu Tyr Pro Gly Asp His Gly Lys Lys Thr Pro Asn Pro
                405                 410                 415
Ala Asn Gln Tyr Gln Phe Asp Lys Val Gly Ile Leu Thr Leu Ser Asp
            420                 425                 430
Tyr Val Leu Glu Leu Gly His Pro Tyr Leu Trp Val Gln Lys Leu Gly
        435                 440                 445
Gly Leu His Phe Pro Lys Glu Gln Pro Gln Gln Thr Val Ile Ala Asp
    450                 455                 460
His Ser Leu Ser Ala Ser His Met Glu Thr Thr Met Lys Leu Leu Lys
465                 470                 475                 480
Thr Arg Val Gln Ser Arg Leu Ala Leu His Lys Gln Phe Ala Ser Leu
                485                 490                 495
Glu His Gly Ile Val Pro Val Thr Ser Asp Cys Gln Tyr Leu Phe Pro
            500                 505                 510
Ala Lys Val Val Ser Arg Leu Val Lys Trp Val Thr Ile Ala His Glu
        515                 520                 525
Asp Tyr Met Glu Leu His Phe Thr Lys Asp Ile Val Asp Ala Gly Leu
    530                 535                 540
Ala Gly Asp Thr Asn Leu Tyr Tyr Met Ala Leu Ile Glu Arg Gly Thr
545                 550                 555                 560
Ala Lys Leu Gln Ala Ala Val Val Leu Asn Pro Gly Tyr Ser Ser Ile
                565                 570                 575
Pro Pro Ile Phe Gln Leu Cys Leu Asn Trp Lys Gly Glu Lys Thr Asn
            580                 585                 590
Ser Asn Asp Asp Asn Ile Arg Ala Met Glu Gly Glu Val Asn Val Cys
        595                 600                 605
Tyr Lys Glu Leu Cys Gly Pro Trp Pro Ser His Gln Leu Leu Thr Asn
    610                 615                 620
Gln Leu Gln Arg Leu Cys Val Leu Leu Asp Val Tyr Leu Glu Thr Glu
625                 630                 635                 640
Ser His Asp Asp Ser Val Glu Gly Pro Lys Glu Phe Pro Gln Glu Lys
                645                 650                 655
Met Cys Leu Arg Leu Phe Arg Gly Pro Ser Arg Met Lys Pro Phe Lys
            660                 665                 670
Tyr Asn His Pro Gln Gly Phe Phe Ser His Arg
        675                 680

<210> 515
<211> 683
<212> PRT
<213> Homo sapiens

<400> 515
Met Ser Ser Glu Ser Ser Lys Lys Arg Lys Pro Lys Val Ile Arg Ser
 1               5                  10                  15
Asp Gly Ala Pro Ala Glu Gly Lys Arg Asn Arg Ser Asp Thr Glu Gln
            20                  25                  30
Glu Gly Lys Tyr Tyr Ser Glu Glu Ala Glu Val Asp Leu Arg Asp Pro
        35                  40                  45
Gly Arg Asp Tyr Glu Leu Tyr Lys Tyr Thr Cys Gln Glu Leu Gln Arg
    50                  55                  60
Leu Met Ala Glu Ile Gln Asp Leu Lys Ser Arg Gly Gly Lys Asp Val
65                  70                  75                  80
Ala Ile Glu Ile Glu Glu Arg Arg Ile Gln Ser Cys Val His Phe Met
                85                  90                  95
Thr Leu Lys Lys Leu Asn Arg Leu Ala His Ile Arg Leu Lys Lys Gly
            100                 105                 110
Arg Asp Gln Thr His Glu Ala Lys Gln Lys Val Asp Ala Tyr His Leu
        115                 120                 125
Gln Leu Gln Asn Leu Leu Tyr Glu Val Met His Leu Gln Lys Glu Ile
    130                 135                 140
Thr Lys Cys Leu Glu Phe Lys Ser Lys His Glu Glu Ile Asp Leu Val
145                 150                 155                 160
Ser Leu Glu Glu Phe Tyr Lys Glu Ala Pro Pro Asp Ile Ser Lys Ala
                165                 170                 175
Glu Val Thr Met Gly Asp Pro His Gln Gln Thr Leu Ala Arg Leu Asp
            180                 185                 190
Trp Glu Leu Glu Gln Arg Lys Arg Leu Ala Glu Lys Tyr Arg Glu Cys
        195                 200                 205
Leu Ser Asn Lys Glu Lys Ile Leu Lys Glu Ile Glu Val Lys Lys Glu
    210                 215                 220
Tyr Leu Ser Ser Leu Gln Pro Arg Leu Asn Ser Ile Met Gln Ala Ser
225                 230                 235                 240
Leu Pro Val Gln Glu Tyr Leu Phe Met Pro Phe Asp Gln Ala His Lys
                245                 250                 255
Gln Tyr Glu Thr Ala Arg His Leu Pro Pro Pro Leu Tyr Val Leu Phe
            260                 265                 270
Val Gln Ala Thr Ala Tyr Gly Gln Ala Cys Asp Lys Thr Leu Ser Val
        275                 280                 285
Ala Ile Glu Gly Ser Val Asp Glu Ala Lys Ala Leu Phe Lys Pro Pro
    290                 295                 300
Glu Asp Ser Gln Asp Asp Glu Ser Asp Ser Asp Ala Glu Glu Glu Gln
305                 310                 315                 320
Thr Thr Lys Arg Arg Arg Pro Thr Leu Gly Val Gln Leu Asp Asp Lys
                325                 330                 335
Arg Lys Glu Met Leu Lys Arg His Pro Leu Ser Val Met Leu Asp Leu
            340                 345                 350
Lys Cys Lys Asp Asp Ser Val Leu His Leu Thr Phe Tyr Tyr Leu Met
        355                 360                 365
Asn Leu Asn Ile Met Thr Val Lys Ala Lys Val Thr Thr Ala Met Glu
    370                 375                 380
Leu Ile Thr Pro Ile Ser Ala Gly Asp Leu Leu Ser Pro Asp Ser Val
385                 390                 395                 400
Leu Ser Cys Leu Tyr Pro Gly Asp His Gly Lys Lys Thr Pro Asn Pro
                405                 410                 415
Ala Asn Gln Tyr Gln Phe Asp Lys Val Gly Ile Leu Thr Leu Ser Asp
            420                 425                 430
Tyr Val Leu Glu Leu Gly His Pro Tyr Leu Trp Val Gln Lys Leu Gly
        435                 440                 445
Gly Leu His Phe Pro Lys Glu Gln Pro Gln Gln Thr Val Ile Ala Asp
    450                 455                 460
His Ser Leu Ser Ala Ser His Met Glu Thr Thr Met Lys Leu Leu Lys
465                 470                 475                 480
Thr Arg Val Gln Ser Arg Leu Ala Leu His Lys Gln Phe Ala Ser Leu
                485                 490                 495
Glu His Gly Ile Val Pro Val Thr Ser Asp Cys Gln Tyr Leu Phe Pro
            500                 505                 510
Ala Lys Val Val Ser Arg Leu Val Lys Trp Val Thr Ile Ala His Glu
        515                 520                 525
Asp Tyr Met Glu Leu His Phe Thr Lys Asp Ile Val Asp Ala Gly Leu
    530                 535                 540
Ala Gly Asp Thr Asn Leu Tyr Tyr Met Ala Leu Ile Glu Arg Gly Thr
545                 550                 555                 560
Ala Lys Leu Gln Ala Ala Val Val Leu Asn Pro Gly Tyr Ser Ser Ile
                565                 570                 575
Pro Pro Ile Phe Gln Leu Cys Leu Asn Trp Lys Gly Glu Lys Thr Asn
            580                 585                 590
Ser Asn Asp Asp Asn Ile Arg Ala Met Glu Gly Glu Val Asn Val Cys
        595                 600                 605
Tyr Lys Glu Leu Cys Gly Pro Trp Pro Ser His Gln Leu Leu Thr Asn
    610                 615                 620
Gln Leu Gln Arg Leu Cys Val Leu Leu Asp Val Tyr Leu Glu Thr Glu
625                 630                 635                 640
Ser His Asp Asp Ser Val Glu Gly Pro Lys Glu Phe Pro Gln Glu Lys
                645                 650                 655
Met Cys Leu Arg Leu Phe Arg Gly Pro Ser Arg Met Lys Pro Phe Lys
            660                 665                 670
Tyr Asn His Pro Gln Gly Phe Phe Ser His Arg
        675                 680

<210> 516
<211> 683
<212> PRT
<213> Homo sapiens

<400> 516
Met Ser Ser Glu Ser Ser Lys Lys Arg Lys Pro Lys Val Ile Arg Ser
 1               5                  10                  15
Asp Gly Ala Pro Ala Glu Gly Lys Arg Asn Arg Ser Asp Thr Glu Gln
            20                  25                  30
Glu Gly Lys Tyr Tyr Ser Glu Glu Ala Glu Val Asp Leu Arg Asp Pro
        35                  40                  45
Gly Arg Asp Tyr Glu Leu Tyr Lys Tyr Thr Cys Gln Glu Leu Gln Arg
    50                  55                  60
Leu Met Ala Glu Ile Gln Asp Leu Lys Ser Arg Gly Gly Lys Asp Val
65                  70                  75                  80
Ala Ile Glu Ile Glu Glu Arg Arg Ile Gln Ser Cys Val His Phe Met
                85                  90                  95
Thr Leu Lys Lys Leu Asn Arg Leu Ala His Ile Arg Leu Lys Lys Gly
            100                 105                 110
Arg Asp Gln Thr His Glu Ala Lys Gln Lys Val Asp Ala Tyr His Leu
        115                 120                 125
Gln Leu Gln Asn Leu Leu Tyr Glu Val Met His Leu Gln Lys Glu Ile
    130                 135                 140
Thr Lys Cys Leu Glu Phe Lys Ser Lys His Glu Glu Ile Asp Leu Val
145                 150                 155                 160
Ser Leu Glu Glu Phe Tyr Lys Glu Ala Pro Pro Asp Ile Ser Lys Ala
                165                 170                 175
Glu Val Thr Met Gly Asp Pro His Gln Gln Thr Leu Ala Arg Leu Asp
            180                 185                 190
Trp Glu Leu Glu Gln Arg Lys Arg Leu Ala Glu Lys Tyr Arg Glu Cys
        195                 200                 205
Leu Ser Asn Lys Glu Lys Ile Leu Lys Glu Ile Glu Val Lys Lys Glu
    210                 215                 220
Tyr Leu Ser Ser Leu Gln Pro Arg Leu Asn Ser Ile Met Gln Ala Ser
225                 230                 235                 240
Leu Pro Val Gln Glu Tyr Leu Phe Met Pro Phe Asp Gln Ala His Lys
                245                 250                 255
Gln Tyr Glu Thr Ala Arg His Leu Pro Pro Pro Leu Tyr Val Leu Phe
            260                 265                 270
Val Gln Ala Thr Ala Tyr Gly Gln Ala Cys Asp Lys Thr Leu Ser Val
        275                 280                 285
Ala Ile Glu Gly Ser Val Asp Glu Ala Lys Ala Leu Phe Lys Pro Pro
    290                 295                 300
Glu Asp Ser Gln Asp Asp Glu Ser Asp Ser Asp Ala Glu Glu Glu Gln
305                 310                 315                 320
Thr Thr Lys Arg Arg Arg Pro Thr Leu Gly Val Gln Leu Asp Asp Lys
                325                 330                 335
Arg Lys Glu Met Leu Lys Arg His Pro Leu Ser Val Met Leu Asp Leu
            340                 345                 350
Lys Cys Lys Asp Asp Ser Val Leu His Leu Thr Phe Tyr Tyr Leu Met
        355                 360                 365
Asn Leu Asn Ile Met Thr Val Lys Ala Lys Val Thr Thr Ala Met Glu
    370                 375                 380
Leu Ile Thr Pro Ile Ser Ala Gly Asp Leu Leu Ser Pro Asp Ser Val
385                 390                 395                 400
Leu Ser Cys Leu Tyr Pro Gly Asp His Gly Lys Lys Thr Pro Asn Pro
                405                 410                 415
Ala Asn Gln Tyr Gln Phe Asp Lys Val Gly Ile Leu Thr Leu Ser Asp
            420                 425                 430
Tyr Val Leu Glu Leu Gly His Pro Tyr Leu Trp Val Gln Lys Leu Gly
        435                 440                 445
Gly Leu His Phe Pro Lys Glu Gln Pro Gln Gln Thr Val Ile Ala Asp
    450                 455                 460
His Ser Leu Ser Ala Ser His Met Glu Thr Thr Met Lys Leu Leu Lys
465                 470                 475                 480
Thr Arg Val Gln Ser Arg Leu Ala Leu His Lys Gln Phe Ala Ser Leu
                485                 490                 495
Glu His Gly Ile Val Pro Val Thr Ser Asp Cys Gln Tyr Leu Phe Pro
            500                 505                 510
Ala Lys Val Val Ser Arg Leu Val Lys Trp Val Thr Ile Ala His Glu
        515                 520                 525
Asp Tyr Met Glu Leu His Phe Thr Lys Asp Ile Val Asp Ala Gly Leu
    530                 535                 540
Ala Gly Asp Thr Asn Leu Tyr Tyr Met Ala Leu Ile Glu Arg Gly Thr
545                 550                 555                 560
Ala Lys Leu Gln Ala Ala Val Val Leu Asn Pro Gly Tyr Ser Ser Ile
                565                 570                 575
Pro Pro Val Phe Gln Leu Cys Leu Asn Trp Lys Gly Glu Lys Thr Asn
            580                 585                 590
Ser Asn Asp Asp Asn Ile Arg Ala Met Glu Gly Glu Val Asn Val Cys
        595                 600                 605
Tyr Lys Glu Leu Cys Gly Pro Trp Pro Ser His Gln Leu Leu Thr Asn
    610                 615                 620
Gln Leu Gln Arg Leu Cys Val Leu Leu Asp Val Tyr Leu Glu Thr Glu
625                 630                 635                 640
Ser His Asp Asp Ser Val Glu Gly Pro Lys Glu Phe Pro Gln Glu Lys
                645                 650                 655
Met Cys Leu Arg Leu Phe Arg Gly Pro Ser Arg Met Lys Pro Phe Lys
            660                 665                 670
Tyr Asn His Pro Gln Gly Phe Phe Ser His Arg
        675                 680

<210> 517
<211> 260
<212> PRT
<213> Homo sapiens

<400> 517
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys
 1               5                  10                  15
Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu
            20                  25                  30
Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala
        35                  40                  45
Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His
    50                  55                  60
Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr
65                  70                  75                  80
Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu
                85                  90                  95
Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg
            100                 105                 110
Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser
        115                 120                 125
Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His
    130                 135                 140
Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn
145                 150                 155                 160
Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys
                165                 170                 175
Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val
            180                 185                 190
Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys
        195                 200                 205
Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val
    210                 215                 220
Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile
225                 230                 235                 240
His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln
                245                 250                 255
Ile Lys Leu Cys
            260

<210> 518
<211> 419
<212> PRT
<213> Homo sapiens

<400> 518
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys
 1               5                  10                  15
Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu
            20                  25                  30
Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala
        35                  40                  45
Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His
    50                  55                  60
Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr
65                  70                  75                  80
Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu
                85                  90                  95
Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg
            100                 105                 110
Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser
        115                 120                 125
Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Asn Gly His
    130                 135                 140
Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn
145                 150                 155                 160
Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys
                165                 170                 175
Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val
            180                 185                 190
Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys
        195                 200                 205
Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val
    210                 215                 220
Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile
225                 230                 235                 240
His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln
                245                 250                 255
Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys
            260                 265                 270
Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg
        275                 280                 285
Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp
    290                 295                 300
Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe
305                 310                 315                 320
Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu
                325                 330                 335
Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp
            340                 345                 350
Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg
        355                 360                 365
Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu
    370                 375                 380
Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys
385                 390                 395                 400
Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro
                405                 410                 415
Phe Phe Arg


<210> 519
<211> 419
<212> PRT
<213> Homo sapiens

<400> 519
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys
 1               5                  10                  15
Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu
            20                  25                  30
Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala
        35                  40                  45
Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His
    50                  55                  60
Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr
65                  70                  75                  80
Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu
                85                  90                  95
Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg
            100                 105                 110
Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser
        115                 120                 125
Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His
    130                 135                 140
Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn
145                 150                 155                 160
Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys
                165                 170                 175
Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val
            180                 185                 190
Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys
        195                 200                 205
Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val
    210                 215                 220
Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile
225                 230                 235                 240
His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln
                245                 250                 255
Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys
            260                 265                 270
Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg
        275                 280                 285
Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp
    290                 295                 300
Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe
305                 310                 315                 320
Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu
                325                 330                 335
Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp
            340                 345                 350
Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg
        355                 360                 365
Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu
    370                 375                 380
Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys
385                 390                 395                 400
Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro
                405                 410                 415
Phe Phe Arg


<210> 520
<211> 401
<212> PRT
<213> Homo sapiens

<400> 520
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys
 1               5                  10                  15
Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu
            20                  25                  30
Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala
        35                  40                  45
Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His
    50                  55                  60
Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr
65                  70                  75                  80
Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp His Lys Leu
                85                  90                  95
Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg
            100                 105                 110
Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser
        115                 120                 125
Gly Thr Cys Gly Pro Val Trp Lys Met Arg Phe Arg Lys Thr Gly His
    130                 135                 140
Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn
145                 150                 155                 160
Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys
                165                 170                 175
Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val
            180                 185                 190
Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys
        195                 200                 205
Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val
    210                 215                 220
Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile
225                 230                 235                 240
His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln
                245                 250                 255
Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys
            260                 265                 270
Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg
        275                 280                 285
Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp
    290                 295                 300
Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe
305                 310                 315                 320
Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu
                325                 330                 335
Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp
            340                 345                 350
Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg
        355                 360                 365
Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu
    370                 375                 380
Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys
385                 390                 395                 400
Thr


<210> 521
<211> 435
<212> PRT
<213> Homo sapiens

<400> 521
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys
 1               5                  10                  15
Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu
            20                  25                  30
Asp Ile Ser Pro Gln Arg Pro Arg Pro Ile Ile Val Ile Thr Leu Ser
        35                  40                  45
Pro Ala Pro Ala Pro Ser Gln Arg Ala Ala Leu Gln Leu Pro Leu Ala
    50                  55                  60
Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His
65                  70                  75                  80
Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr
                85                  90                  95
Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu
            100                 105                 110
Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg
        115                 120                 125
Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser
    130                 135                 140
Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His
145                 150                 155                 160
Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn
                165                 170                 175
Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys
            180                 185                 190
Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val
        195                 200                 205
Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys
    210                 215                 220
Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val
225                 230                 235                 240
Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile
                245                 250                 255
His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln
            260                 265                 270
Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys
        275                 280                 285
Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg
    290                 295                 300
Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp
305                 310                 315                 320
Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe
                325                 330                 335
Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu
            340                 345                 350
Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp
        355                 360                 365
Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg
    370                 375                 380
Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu
385                 390                 395                 400
Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys
                405                 410                 415
Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro
            420                 425                 430
Phe Phe Arg
        435

<210> 522
<211> 260
<212> PRT
<213> Homo sapiens

<400> 522
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys
 1               5                  10                  15
Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu
            20                  25                  30
Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala
        35                  40                  45
Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His
    50                  55                  60
Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr
65                  70                  75                  80
Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu
                85                  90                  95
Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg
            100                 105                 110
Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser
        115                 120                 125
Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His
    130                 135                 140
Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn
145                 150                 155                 160
Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys
                165                 170                 175
Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val
            180                 185                 190
Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys
        195                 200                 205
Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val
    210                 215                 220
Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile
225                 230                 235                 240
His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln
                245                 250                 255
Ile Lys Leu Cys
            260

<210> 523
<211> 333
<212> PRT
<213> Homo sapiens

<400> 523
Met Glu Ser Ile Glu Ile Asp Gln Lys Leu Gln Glu Ile Met Lys Gln
 1               5                  10                  15
Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg Tyr Gln Ala Glu Ile Asn
            20                  25                  30
Asp Leu Glu Asn Leu Gly Glu Met Gly Ser Gly Thr Cys Gly Gln Val
        35                  40                  45
Trp Lys Met Arg Phe Arg Lys Thr Gly His Val Ile Ala Val Lys Gln
    50                  55                  60
Met Arg Arg Ser Gly Asn Lys Glu Glu Asn Lys Arg Ile Leu Met Asp
65                  70                  75                  80
Leu Asp Val Val Leu Lys Ser His Asp Cys Pro Tyr Ile Val Gln Cys
                85                  90                  95
Phe Gly Thr Phe Ile Thr Asn Thr Asp Val Phe Ile Ala Met Glu Leu
            100                 105                 110
Met Gly Thr Cys Ala Glu Lys Leu Lys Lys Arg Met Gln Gly Pro Ile
        115                 120                 125
Pro Glu Arg Ile Leu Gly Lys Met Thr Val Ala Ile Val Lys Ala Leu
    130                 135                 140
Tyr Tyr Leu Lys Glu Lys His Gly Val Ile His Arg Asp Val Lys Pro
145                 150                 155                 160
Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln Ile Lys Leu Cys Asp Phe
                165                 170                 175
Gly Ile Ser Gly Arg Leu Val Asp Ser Lys Ala Lys Thr Arg Ser Ala
            180                 185                 190
Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg Ile Asp Pro Pro Asp Pro
        195                 200                 205
Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp Val Trp Ser Leu Gly Ile
    210                 215                 220
Ser Leu Val Glu Leu Ala Thr Gly Gln Phe Pro Tyr Lys Asn Cys Lys
225                 230                 235                 240
Thr Asp Phe Glu Val Leu Thr Lys Val Leu Gln Glu Glu Pro Pro Leu
                245                 250                 255
Leu Pro Gly His Met Gly Phe Ser Gly Asp Phe Gln Ser Phe Val Lys
            260                 265                 270
Asp Cys Leu Thr Lys Asp His Arg Lys Arg Pro Lys Tyr Asn Lys Leu
        275                 280                 285
Leu Glu His Ser Phe Ile Lys Arg Tyr Glu Thr Leu Glu Val Asp Val
    290                 295                 300
Ala Ser Trp Phe Lys Asp Val Met Ala Lys Thr Glu Ser Pro Arg Thr
305                 310                 315                 320
Ser Gly Val Leu Ser Gln Pro His Leu Pro Phe Phe Arg
                325                 330

<210> 524
<211> 419
<212> PRT
<213> Homo sapiens

<400> 524
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys
 1               5                  10                  15
Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu
            20                  25                  30
Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala
        35                  40                  45
Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His
    50                  55                  60
Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr
65                  70                  75                  80
Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu
                85                  90                  95
Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg
            100                 105                 110
Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser
        115                 120                 125
Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His
    130                 135                 140
Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn
145                 150                 155                 160
Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys
                165                 170                 175
Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val
            180                 185                 190
Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys
        195                 200                 205
Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val
    210                 215                 220
Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile
225                 230                 235                 240
His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln
                245                 250                 255
Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys
            260                 265                 270
Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg
        275                 280                 285
Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp
    290                 295                 300
Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe
305                 310                 315                 320
Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu
                325                 330                 335
Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp
            340                 345                 350
Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg
        355                 360                 365
Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu
    370                 375                 380
Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys
385                 390                 395                 400
Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro
                405                 410                 415
Phe Phe Arg


<210> 525
<211> 419
<212> PRT
<213> Homo sapiens

<400> 525
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys
 1               5                  10                  15
Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu
            20                  25                  30
Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala
        35                  40                  45
Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His
    50                  55                  60
Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr
65                  70                  75                  80
Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu
                85                  90                  95
Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg
            100                 105                 110
Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser
        115                 120                 125
Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His
    130                 135                 140
Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn
145                 150                 155                 160
Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys
                165                 170                 175
Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val
            180                 185                 190
Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys
        195                 200                 205
Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val
    210                 215                 220
Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile
225                 230                 235                 240
His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln
                245                 250                 255
Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys
            260                 265                 270
Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg
        275                 280                 285
Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp
    290                 295                 300
Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe
305                 310                 315                 320
Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu
                325                 330                 335
Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp
            340                 345                 350
Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg
        355                 360                 365
Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu
    370                 375                 380
Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys
385                 390                 395                 400
Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro
                405                 410                 415
Phe Phe Arg


<210> 526
<211> 419
<212> PRT
<213> Homo sapiens

<400> 526
Met Ala Ala Ser Ser Leu Glu Gln Lys Leu Ser Arg Leu Glu Ala Lys
 1               5                  10                  15
Leu Lys Gln Glu Asn Arg Glu Ala Arg Arg Arg Ile Asp Leu Asn Leu
            20                  25                  30
Asp Ile Ser Pro Gln Arg Pro Arg Pro Thr Leu Gln Leu Pro Leu Ala
        35                  40                  45
Asn Asp Gly Gly Ser Arg Ser Pro Ser Ser Glu Ser Ser Pro Gln His
    50                  55                  60
Pro Thr Pro Pro Ala Arg Pro Arg His Met Leu Gly Leu Pro Ser Thr
65                  70                  75                  80
Leu Phe Thr Pro Arg Ser Met Glu Ser Ile Glu Ile Asp Gln Lys Leu
                85                  90                  95
Gln Glu Ile Met Lys Gln Thr Gly Tyr Leu Thr Ile Gly Gly Gln Arg
            100                 105                 110
Tyr Gln Ala Glu Ile Asn Asp Leu Glu Asn Leu Gly Glu Met Gly Ser
        115                 120                 125
Gly Thr Cys Gly Gln Val Trp Lys Met Arg Phe Arg Lys Thr Gly His
    130                 135                 140
Val Ile Ala Val Lys Gln Met Arg Arg Ser Gly Asn Lys Glu Glu Asn
145                 150                 155                 160
Lys Arg Ile Leu Met Asp Leu Asp Val Val Leu Lys Ser His Asp Cys
                165                 170                 175
Pro Tyr Ile Val Gln Cys Phe Gly Thr Phe Ile Thr Asn Thr Asp Val
            180                 185                 190
Phe Ile Ala Met Glu Leu Met Gly Thr Cys Ala Glu Lys Leu Lys Lys
        195                 200                 205
Arg Met Gln Gly Pro Ile Pro Glu Arg Ile Leu Gly Lys Met Thr Val
    210                 215                 220
Ala Ile Val Lys Ala Leu Tyr Tyr Leu Lys Glu Lys His Gly Val Ile
225                 230                 235                 240
His Arg Asp Val Lys Pro Ser Asn Ile Leu Leu Asp Glu Arg Gly Gln
                245                 250                 255
Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Arg Leu Val Asp Ser Lys
            260                 265                 270
Ala Lys Thr Arg Ser Ala Gly Cys Ala Ala Tyr Met Ala Pro Glu Arg
        275                 280                 285
Ile Asp Pro Pro Asp Pro Thr Lys Pro Asp Tyr Asp Ile Arg Ala Asp
    290                 295                 300
Val Trp Ser Leu Gly Ile Ser Leu Val Glu Leu Ala Thr Gly Gln Phe
305                 310                 315                 320
Pro Tyr Lys Asn Cys Lys Thr Asp Phe Glu Val Leu Thr Lys Val Leu
                325                 330                 335
Gln Glu Glu Pro Pro Leu Leu Pro Gly His Met Gly Phe Ser Gly Asp
            340                 345                 350
Phe Gln Ser Phe Val Lys Asp Cys Leu Thr Lys Asp His Arg Lys Arg
        355                 360                 365
Pro Lys Tyr Asn Lys Leu Leu Glu His Ser Phe Ile Lys Arg Tyr Glu
    370                 375                 380
Thr Leu Glu Val Asp Val Ala Ser Trp Phe Lys Asp Val Met Ala Lys
385                 390                 395                 400
Thr Glu Ser Pro Arg Thr Ser Gly Val Leu Ser Gln Pro His Leu Pro
                405                 410                 415
Phe Phe Arg


<210> 527
<211> 439
<212> PRT
<213> Homo sapiens

<400> 527
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 528
<211> 439
<212> PRT
<213> Homo sapiens

<400> 528
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 529
<211> 439
<212> PRT
<213> Homo sapiens

<400> 529
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 530
<211> 439
<212> PRT
<213> Homo sapiens

<400> 530
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 531
<211> 439
<212> PRT
<213> Homo sapiens

<400> 531
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 532
<211> 170
<212> PRT
<213> Homo sapiens

<400> 532
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val
                165                 170

<210> 533
<211> 257
<212> PRT
<213> Homo sapiens

<400> 533
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Gly Gly Thr Arg
                245                 250                 255
Arg


<210> 534
<211> 439
<212> PRT
<213> Homo sapiens

<400> 534
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 535
<211> 252
<212> PRT
<213> Homo sapiens

<400> 535
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Pro Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser
                245                 250

<210> 536
<211> 439
<212> PRT
<213> Homo sapiens

<400> 536
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 537
<211> 439
<212> PRT
<213> Homo sapiens

<400> 537
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 538
<211> 252
<212> PRT
<213> Homo sapiens

<400> 538
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser
                245                 250

<210> 539
<211> 439
<212> PRT
<213> Homo sapiens

<400> 539
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 540
<211> 439
<212> PRT
<213> Homo sapiens

<400> 540
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 541
<211> 439
<212> PRT
<213> Homo sapiens

<400> 541
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 542
<211> 439
<212> PRT
<213> Homo sapiens

<400> 542
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 543
<211> 454
<212> PRT
<213> Homo sapiens

<400> 543
Met Asn Phe Phe Arg Glu Val Glu Asn Gln Gln Pro Pro Ala Thr Met
 1               5                  10                  15
Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp
            20                  25                  30
Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln
        35                  40                  45
Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile
    50                  55                  60
Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg
65                  70                  75                  80
Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser
                85                  90                  95
Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp
            100                 105                 110
Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln
        115                 120                 125
Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile
    130                 135                 140
Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val
145                 150                 155                 160
Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser
                165                 170                 175
Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr
            180                 185                 190
Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val
        195                 200                 205
Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala
    210                 215                 220
Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser
225                 230                 235                 240
Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His
                245                 250                 255
Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu
            260                 265                 270
Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro
        275                 280                 285
Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys
    290                 295                 300
Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His
305                 310                 315                 320
Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala
                325                 330                 335
Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser
            340                 345                 350
Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn
        355                 360                 365
Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu
    370                 375                 380
Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu
385                 390                 395                 400
Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala
                405                 410                 415
Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu
            420                 425                 430
Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln
        435                 440                 445
Leu Arg Asn Ser Cys Ala
    450

<210> 544
<211> 439
<212> PRT
<213> Homo sapiens

<400> 544
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 545
<211> 439
<212> PRT
<213> Homo sapiens

<400> 545
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 546
<211> 439
<212> PRT
<213> Homo sapiens

<400> 546
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln
                245                 250                 255
Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala
            260                 265                 270
Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser
        275                 280                 285
Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr
    290                 295                 300
His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro
305                 310                 315                 320
Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile
                325                 330                 335
Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu
            340                 345                 350
Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn
        355                 360                 365
Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu
    370                 375                 380
Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr
385                 390                 395                 400
Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu
                405                 410                 415
Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu
            420                 425                 430
Gln Leu Arg Asn Ser Cys Ala
        435

<210> 547
<211> 252
<212> PRT
<213> Homo sapiens

<400> 547
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr
 1               5                  10                  15
Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr
            20                  25                  30
Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp
        35                  40                  45
Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Pro Pro Ser
    50                  55                  60
Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe
65                  70                  75                  80
Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala
                85                  90                  95
Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn
            100                 105                 110
Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile
        115                 120                 125
Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu
    130                 135                 140
Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly
145                 150                 155                 160
Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu
                165                 170                 175
Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser
            180                 185                 190
Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys
        195                 200                 205
Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu
    210                 215                 220
Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu
225                 230                 235                 240
His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser
                245                 250

<210> 548
<211> 755
<212> PRT
<213> Homo sapiens

<400> 548
Met Ser Gly Thr Asn Leu Asp Gly Asn Asp Glu Phe Asp Glu Gln Leu
 1               5                  10                  15
Arg Met Gln Glu Leu Tyr Gly Asp Gly Lys Asp Gly Asp Thr Gln Thr
            20                  25                  30
Asp Ala Gly Gly Glu Pro Asp Ser Leu Gly Gln Gln Pro Thr Asp Thr
        35                  40                  45
Pro Tyr Glu Trp Asp Leu Asp Lys Lys Ala Trp Phe Pro Lys Ile Thr
    50                  55                  60
Glu Asp Phe Ile Ala Thr Tyr Gln Ala Asn Tyr Gly Phe Ser Asn Asp
65                  70                  75                  80
Gly Ala Ser Ser Ser Thr Ala Asn Val Glu Asp Val His Ala Arg Thr
                85                  90                  95
Ala Glu Glu Pro Pro Gln Glu Lys Ala Pro Glu Pro Thr Asp Ala Arg
            100                 105                 110
Lys Lys Gly Glu Lys Arg Lys Ala Glu Ser Gly Trp Phe His Val Glu
        115                 120                 125
Glu Asp Arg Asn Thr Asn Val Tyr Val Ser Gly Leu Pro Pro Asp Ile
    130                 135                 140
Thr Val Asp Glu Phe Ile Gln Leu Met Ser Lys Phe Gly Ile Ile Met
145                 150                 155                 160
Arg Asp Pro Gln Thr Glu Glu Phe Lys Val Lys Leu Tyr Lys Asp Asn
                165                 170                 175
Gln Gly Asn Leu Lys Gly Asp Gly Leu Cys Cys Tyr Leu Lys Arg Glu
            180                 185                 190
Ser Val Glu Leu Ala Leu Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly
        195                 200                 205
Tyr Lys Leu His Val Glu Val Ala Lys Phe Gln Leu Lys Gly Glu Tyr
    210                 215                 220
Asp Ala Ser Lys Lys Lys Lys Lys Cys Lys Asp Tyr Lys Lys Lys Leu
225                 230                 235                 240
Ser Met Gln Gln Lys Gln Leu Asp Trp Arg Pro Glu Arg Arg Ala Gly
                245                 250                 255
Pro Ser Arg Met Arg His Glu Arg Val Val Ile Ile Lys Asn Met Phe
            260                 265                 270
His Pro Met Asp Phe Glu Asp Asp Pro Leu Val Leu Asn Glu Ile Arg
        275                 280                 285
Glu Asp Leu Arg Val Glu Cys Ser Lys Phe Gly Gln Ile Arg Lys Leu
    290                 295                 300
Leu Leu Phe Asp Arg His Pro Asp Gly Val Ala Ser Val Ser Phe Arg
305                 310                 315                 320
Asp Pro Glu Glu Ala Asp Tyr Cys Ile Gln Thr Leu Asp Gly Arg Trp
                325                 330                 335
Phe Gly Gly Arg Gln Ile Thr Ala Gln Ala Trp Asp Gly Thr Thr Asp
            340                 345                 350
Tyr Gln Val Glu Glu Thr Ser Arg Glu Arg Glu Glu Arg Leu Arg Gly
        355                 360                 365
Trp Glu Ala Phe Leu Asn Ala Pro Glu Ala Asn Arg Gly Leu Arg Arg
    370                 375                 380
Ser Asp Ser Val Ser Ala Ser Glu Arg Ala Gly Pro Ser Arg Ala Arg
385                 390                 395                 400
His Phe Ser Glu His Pro Ser Thr Ser Lys Met Asn Ala Gln Glu Thr
                405                 410                 415
Ala Thr Gly Met Ala Phe Glu Glu Pro Ile Asp Glu Lys Lys Phe Glu
            420                 425                 430
Lys Thr Glu Asp Gly Gly Glu Phe Glu Glu Gly Ala Ser Glu Asn Asn
        435                 440                 445
Ala Lys Glu Ser Ser Pro Glu Lys Glu Ala Glu Glu Gly Cys Pro Glu
    450                 455                 460
Lys Glu Ser Glu Glu Gly Cys Pro Lys Arg Gly Phe Glu Gly Ser Cys
465                 470                 475                 480
Ser Gln Lys Glu Ser Glu Glu Gly Asn Pro Val Arg Gly Ser Glu Glu
                485                 490                 495
Asp Ser Pro Lys Lys Glu Ser Lys Lys Lys Thr Leu Lys Asn Asp Cys
            500                 505                 510
Glu Glu Asn Gly Leu Ala Lys Glu Ser Glu Asp Asp Leu Asn Lys Glu
        515                 520                 525
Ser Glu Glu Glu Val Gly Pro Thr Lys Glu Ser Glu Glu Asp Asp Ser
    530                 535                 540
Glu Lys Glu Ser Asp Glu Asp Cys Ser Glu Lys Gln Ser Glu Asp Gly
545                 550                 555                 560
Ser Glu Arg Glu Phe Glu Glu Asn Gly Leu Glu Lys Asp Leu Asp Glu
                565                 570                 575
Glu Gly Ser Glu Lys Glu Leu His Glu Asn Val Leu Asp Lys Glu Leu
            580                 585                 590
Glu Glu Asn Asp Ser Glu Asn Ser Glu Phe Glu Asp Asp Gly Ser Glu
        595                 600                 605
Lys Val Leu Asp Glu Glu Gly Ser Glu Arg Glu Phe Asp Glu Asp Ser
    610                 615                 620
Asp Glu Lys Glu Glu Glu Glu Asp Thr Tyr Glu Lys Val Phe Asp Asp
625                 630                 635                 640
Glu Ser Asp Glu Lys Glu Asp Glu Glu Tyr Ala Asp Glu Lys Gly Leu
                645                 650                 655
Glu Ala Ala Asp Lys Lys Ala Glu Glu Gly Asp Ala Asp Glu Lys Leu
            660                 665                 670
Phe Glu Glu Ser Asp Asp Lys Glu Asp Glu Asp Ala Asp Gly Lys Glu
        675                 680                 685
Val Glu Asp Ala Asp Glu Lys Leu Phe Glu Asp Asp Asp Ser Asn Glu
    690                 695                 700
Lys Leu Phe Asp Glu Glu Glu Asp Ser Ser Glu Lys Leu Phe Asp Asp
705                 710                 715                 720
Ser Asp Glu Arg Gly Thr Leu Gly Gly Phe Gly Ser Val Glu Glu Gly
                725                 730                 735
Pro Leu Ser Thr Gly Ser Ser Phe Ile Leu Ser Ser Asp Asp Asp Asp
            740                 745                 750
Asp Asp Ile
        755

<210> 549
<211> 754
<212> PRT
<213> Homo sapiens

<400> 549
Met Ser Gly Thr Asn Leu Asp Gly Asn Asp Glu Phe Asp Glu Gln Leu
 1               5                  10                  15
Arg Met Gln Glu Leu Tyr Gly Asp Gly Lys Asp Gly Asp Thr Gln Thr
            20                  25                  30
Asp Ala Gly Gly Glu Pro Asp Ser Leu Gly Gln Gln Pro Thr Asp Thr
        35                  40                  45
Pro Tyr Glu Trp Asp Leu Asp Lys Lys Ala Trp Phe Pro Lys Ile Thr
    50                  55                  60
Glu Asp Phe Ile Ala Thr Tyr Gln Ala Asn Tyr Gly Phe Ser Asn Asp
65                  70                  75                  80
Gly Ala Ser Ser Ser Thr Ala Asn Val Glu Asp Val His Ala Arg Thr
                85                  90                  95
Ala Glu Glu Pro Pro Gln Glu Lys Ala Pro Glu Pro Thr Asp Ala Arg
            100                 105                 110
Lys Lys Gly Glu Lys Arg Lys Ala Glu Ser Gly Trp Phe His Val Glu
        115                 120                 125
Glu Asp Arg Asn Thr Asn Val Tyr Val Ser Gly Leu Pro Pro Asp Ile
    130                 135                 140
Thr Val Asp Glu Phe Ile Gln Leu Met Ser Lys Phe Gly Ile Ile Met
145                 150                 155                 160
Arg Asp Pro Gln Thr Glu Glu Phe Lys Val Lys Leu Tyr Lys Asp Asn
                165                 170                 175
Gln Gly Asn Leu Lys Gly Asp Gly Leu Cys Cys Tyr Leu Lys Arg Glu
            180                 185                 190
Ser Val Glu Leu Ala Leu Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly
        195                 200                 205
Tyr Lys Leu His Val Glu Val Ala Lys Phe Gln Leu Lys Gly Glu Tyr
    210                 215                 220
Asp Ala Ser Lys Lys Lys Lys Lys Cys Lys Asp Tyr Lys Lys Lys Leu
225                 230                 235                 240
Ser Met Gln Gln Lys Gln Leu Asp Trp Arg Pro Glu Arg Arg Ala Gly
                245                 250                 255
Pro Ser Arg Met Arg His Glu Arg Val Val Ile Ile Lys Asn Met Phe
            260                 265                 270
His Pro Met Asp Phe Glu Asp Asp Pro Leu Val Leu Asn Glu Ile Arg
        275                 280                 285
Glu Asp Leu Arg Val Glu Cys Ser Lys Phe Gly Gln Ile Arg Lys Leu
    290                 295                 300
Leu Leu Phe Asp Arg His Pro Asp Gly Val Ala Ser Val Ser Phe Arg
305                 310                 315                 320
Asp Pro Glu Glu Ala Asp Tyr Cys Ile Gln Thr Leu Asp Gly Arg Trp
                325                 330                 335
Phe Gly Gly Arg Gln Ile Thr Ala Gln Ala Trp Asp Gly Thr Thr Asp
            340                 345                 350
Tyr Gln Val Glu Glu Thr Ser Arg Glu Arg Glu Glu Arg Leu Arg Gly
        355                 360                 365
Trp Glu Ala Phe Leu Asn Ala Pro Glu Ala Asn Arg Gly Leu Ser Val
    370                 375                 380
Gln Ile Leu Ser Leu Leu Arg Lys Ala Gly Pro Ser Arg Ala Arg His
385                 390                 395                 400
Phe Ser Glu His Pro Ser Thr Ser Lys Met Asn Ala Gln Glu Thr Ala
                405                 410                 415
Thr Gly Met Ala Phe Glu Glu Pro Ile Asp Glu Lys Lys Phe Glu Lys
            420                 425                 430
Thr Glu Asp Gly Gly Glu Phe Glu Glu Gly Ala Ser Glu Asn Asn Ala
        435                 440                 445
Lys Glu Ser Ser Pro Glu Lys Glu Ala Glu Glu Gly Cys Pro Glu Lys
    450                 455                 460
Glu Ser Glu Glu Gly Cys Pro Lys Arg Gly Phe Glu Gly Ser Cys Ser
465                 470                 475                 480
Gln Lys Glu Ser Glu Glu Gly Asn Pro Val Arg Gly Ser Glu Glu Asp
                485                 490                 495
Ser Pro Lys Lys Glu Ser Lys Lys Lys Thr Leu Lys Asn Asp Cys Glu
            500                 505                 510
Glu Asn Gly Leu Ala Lys Glu Ser Glu Asp Asp Leu Asn Lys Glu Ser
        515                 520                 525
Glu Glu Glu Val Gly Pro Thr Lys Glu Ser Glu Glu Asp Asp Ser Glu
    530                 535                 540
Lys Glu Ser Asp Glu Asp Cys Ser Glu Lys Gln Ser Glu Asp Gly Ser
545                 550                 555                 560
Glu Arg Glu Phe Glu Glu Asn Gly Leu Glu Lys Asp Leu Asp Glu Glu
                565                 570                 575
Gly Ser Glu Lys Glu Leu His Glu Asn Val Leu Asp Lys Glu Leu Glu
            580                 585                 590
Glu Asn Asp Ser Glu Asn Ser Glu Phe Glu Asp Asp Gly Ser Glu Lys
        595                 600                 605
Val Leu Asp Glu Glu Gly Ser Glu Arg Glu Phe Asp Glu Asp Ser Asp
    610                 615                 620
Glu Lys Glu Glu Glu Glu Asp Thr Tyr Glu Lys Val Phe Asp Asp Glu
625                 630                 635                 640
Ser Asp Glu Lys Glu Asp Glu Glu Tyr Ala Asp Glu Lys Gly Leu Glu
                645                 650                 655
Ala Ala Asp Lys Lys Ala Glu Glu Gly Asp Ala Asp Glu Lys Leu Phe
            660                 665                 670
Glu Glu Ser Asp Asp Lys Glu Asp Glu Asp Ala Asp Gly Lys Glu Val
        675                 680                 685
Glu Asp Ala Asp Glu Lys Leu Phe Glu Asp Asp Asp Ser Asn Glu Lys
    690                 695                 700
Leu Phe Asp Glu Glu Glu Asp Ser Ser Glu Lys Leu Phe Asp Asp Ser
705                 710                 715                 720
Asp Glu Arg Gly Thr Leu Gly Gly Phe Gly Ser Val Glu Glu Gly Pro
                725                 730                 735
Leu Ser Thr Gly Ser Ser Phe Ile Leu Ser Ser Asp Asp Asp Asp Asp
            740                 745                 750
Asp Ile


<210> 550
<211> 755
<212> PRT
<213> Homo sapiens

<400> 550
Met Ser Gly Thr Asn Leu Asp Gly Asn Asp Glu Phe Asp Glu Gln Leu
 1               5                  10                  15
Arg Met Gln Glu Leu Tyr Gly Asp Gly Lys Asp Gly Asp Thr Gln Thr
            20                  25                  30
Asp Ala Gly Gly Glu Pro Asp Ser Leu Gly Gln Gln Pro Thr Asp Thr
        35                  40                  45
Pro Tyr Glu Trp Asp Leu Asp Lys Lys Ala Trp Phe Pro Lys Ile Thr
    50                  55                  60
Glu Asp Phe Ile Ala Thr Tyr Gln Ala Asn Tyr Gly Phe Ser Asn Asp
65                  70                  75                  80
Gly Ala Ser Ser Ser Thr Ala Asn Val Glu Asp Val His Ala Arg Thr
                85                  90                  95
Ala Glu Glu Pro Pro Gln Glu Lys Ala Pro Glu Pro Thr Asp Ala Arg
            100                 105                 110
Lys Lys Gly Glu Lys Arg Lys Ala Glu Ser Gly Trp Phe His Val Glu
        115                 120                 125
Glu Asp Arg Asn Thr Asn Val Tyr Val Ser Gly Leu Pro Pro Asp Ile
    130                 135                 140
Thr Val Asp Glu Phe Ile Gln Leu Met Ser Lys Phe Gly Ile Ile Met
145                 150                 155                 160
Arg Asp Pro Gln Thr Glu Glu Phe Lys Val Lys Leu Tyr Lys Asp Asn
                165                 170                 175
Gln Gly Asn Leu Lys Gly Asp Gly Leu Cys Cys Tyr Leu Lys Arg Glu
            180                 185                 190
Ser Val Glu Leu Ala Leu Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly
        195                 200                 205
Tyr Lys Leu His Val Glu Val Ala Lys Phe Gln Leu Lys Gly Glu Tyr
    210                 215                 220
Asp Ala Ser Lys Lys Lys Lys Lys Cys Lys Asp Tyr Lys Lys Lys Leu
225                 230                 235                 240
Ser Met Gln Gln Lys Gln Leu Asp Trp Arg Pro Glu Arg Arg Ala Gly
                245                 250                 255
Pro Ser Arg Met Arg His Glu Arg Val Val Ile Ile Lys Asn Met Phe
            260                 265                 270
His Pro Met Asp Phe Glu Asp Asp Pro Leu Val Leu Asn Glu Ile Arg
        275                 280                 285
Glu Asp Leu Arg Val Glu Cys Ser Lys Phe Gly Gln Ile Arg Lys Leu
    290                 295                 300
Leu Leu Phe Asp Arg His Pro Asp Gly Val Ala Ser Val Ser Phe Arg
305                 310                 315                 320
Asp Pro Glu Glu Ala Asp Tyr Cys Ile Gln Thr Leu Asp Gly Arg Trp
                325                 330                 335
Phe Gly Gly Arg Gln Ile Thr Ala Gln Ala Trp Asp Gly Thr Thr Asp
            340                 345                 350
Tyr Gln Val Glu Glu Thr Ser Arg Glu Arg Glu Glu Arg Leu Arg Gly
        355                 360                 365
Trp Glu Ala Phe Leu Asn Ala Pro Glu Ala Asn Arg Gly Leu Arg Arg
    370                 375                 380
Ser Asp Ser Val Ser Ala Ser Glu Arg Ala Gly Pro Ser Arg Ala Arg
385                 390                 395                 400
His Phe Ser Glu His Pro Ser Thr Ser Lys Met Asn Ala Gln Glu Thr
                405                 410                 415
Ala Thr Gly Met Ala Phe Glu Glu Pro Ile Asp Glu Lys Lys Phe Glu
            420                 425                 430
Lys Thr Glu Asp Gly Gly Glu Phe Glu Glu Gly Ala Ser Glu Asn Asn
        435                 440                 445
Ala Lys Glu Ser Ser Pro Glu Lys Glu Ala Glu Glu Gly Cys Pro Glu
    450                 455                 460
Lys Glu Ser Glu Glu Gly Cys Pro Lys Arg Gly Phe Glu Gly Ser Cys
465                 470                 475                 480
Ser Gln Lys Glu Ser Glu Glu Gly Asn Pro Val Arg Gly Ser Glu Glu
                485                 490                 495
Asp Ser Pro Lys Lys Glu Ser Lys Lys Lys Thr Leu Lys Asn Asp Cys
            500                 505                 510
Glu Glu Asn Gly Leu Ala Lys Glu Ser Glu Asp Asp Leu Asn Lys Glu
        515                 520                 525
Ser Glu Glu Glu Val Gly Pro Thr Lys Glu Ser Glu Glu Asp Asp Ser
    530                 535                 540
Glu Lys Glu Ser Asp Glu Asp Cys Ser Glu Lys Gln Ser Glu Asp Gly
545                 550                 555                 560
Ser Glu Arg Glu Phe Glu Glu Asn Gly Leu Glu Lys Asp Leu Asp Glu
                565                 570                 575
Glu Gly Ser Glu Lys Glu Leu His Glu Asn Val Leu Asp Lys Glu Leu
            580                 585                 590
Glu Glu Asn Asp Ser Glu Asn Ser Glu Phe Glu Asp Asp Gly Ser Glu
        595                 600                 605
Lys Val Leu Asp Glu Glu Gly Ser Glu Arg Glu Phe Asp Glu Asp Ser
    610                 615                 620
Asp Glu Lys Glu Glu Glu Glu Asp Thr Tyr Glu Lys Val Phe Asp Asp
625                 630                 635                 640
Glu Ser Asp Glu Lys Glu Asp Glu Glu Tyr Ala Asp Glu Lys Gly Leu
                645                 650                 655
Glu Ala Ala Asp Lys Lys Ala Glu Glu Gly Asp Ala Asp Glu Lys Leu
            660                 665                 670
Phe Glu Glu Ser Asp Asp Lys Glu Asp Glu Asp Ala Asp Gly Lys Glu
        675                 680                 685
Val Glu Asp Ala Asp Glu Lys Leu Phe Glu Asp Asp Asp Ser Asn Glu
    690                 695                 700
Lys Leu Phe Asp Glu Glu Glu Asp Ser Ser Glu Lys Leu Phe Asp Asp
705                 710                 715                 720
Ser Asp Glu Arg Gly Thr Leu Gly Gly Phe Gly Ser Val Glu Glu Gly
                725                 730                 735
Pro Leu Ser Thr Gly Ser Ser Phe Ile Leu Ser Ser Asp Asp Asp Asp
            740                 745                 750
Asp Asp Ile
        755

<210> 551
<211> 754
<212> PRT
<213> Homo sapiens

<400> 551
Met Ser Gly Thr Asn Leu Asp Gly Asn Asp Glu Phe Asp Glu Gln Leu
 1               5                  10                  15
Arg Met Gln Glu Leu Tyr Gly Asp Gly Lys Asp Gly Asp Thr Gln Thr
            20                  25                  30
Asp Ala Gly Gly Glu Pro Asp Ser Leu Gly Gln Gln Pro Thr Asp Thr
        35                  40                  45
Pro Tyr Glu Trp Asp Leu Asp Lys Lys Ala Trp Phe Pro Lys Ile Thr
    50                  55                  60
Glu Asp Phe Ile Ala Thr Tyr Gln Ala Asn Tyr Gly Phe Ser Asn Asp
65                  70                  75                  80
Gly Ala Ser Ser Ser Thr Ala Asn Val Glu Asp Val His Ala Arg Thr
                85                  90                  95
Ala Glu Glu Pro Pro Gln Glu Lys Ala Pro Glu Pro Thr Asp Ala Arg
            100                 105                 110
Lys Lys Gly Glu Lys Arg Lys Ala Glu Ser Gly Trp Phe His Val Glu
        115                 120                 125
Glu Asp Arg Asn Thr Asn Val Tyr Val Ser Gly Leu Pro Pro Asp Ile
    130                 135                 140
Thr Val Asp Glu Phe Ile Gln Leu Met Ser Lys Phe Gly Ile Ile Met
145                 150                 155                 160
Arg Asp Pro Gln Thr Glu Glu Phe Lys Val Lys Leu Tyr Lys Asp Asn
                165                 170                 175
Gln Gly Asn Leu Lys Gly Asp Gly Leu Cys Cys Tyr Leu Lys Arg Glu
            180                 185                 190
Ser Val Glu Leu Ala Leu Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly
        195                 200                 205
Tyr Lys Leu His Val Glu Val Ala Lys Phe Gln Leu Lys Gly Glu Tyr
    210                 215                 220
Asp Ala Ser Lys Lys Lys Lys Lys Cys Lys Asp Tyr Lys Lys Lys Leu
225                 230                 235                 240
Ser Met Gln Gln Lys Gln Leu Asp Trp Arg Pro Glu Arg Arg Ala Gly
                245                 250                 255
Pro Ser Arg Met Arg His Glu Arg Val Val Ile Ile Lys Asn Met Phe
            260                 265                 270
His Pro Met Asp Phe Glu Asp Asp Pro Leu Val Leu Asn Glu Ile Arg
        275                 280                 285
Glu Asp Leu Arg Val Glu Cys Ser Lys Phe Gly Gln Ile Arg Lys Leu
    290                 295                 300
Leu Leu Phe Asp Arg His Pro Asp Gly Val Ala Ser Val Ser Phe Arg
305                 310                 315                 320
Asp Pro Glu Glu Ala Asp Tyr Cys Ile Gln Thr Leu Asp Gly Arg Trp
                325                 330                 335
Phe Gly Gly Arg Gln Ile Thr Ala Gln Ala Trp Asp Gly Thr Thr Asp
            340                 345                 350
Tyr Gln Val Glu Glu Thr Ser Arg Glu Arg Glu Glu Arg Leu Arg Gly
        355                 360                 365
Trp Glu Ala Phe Leu Asn Ala Pro Glu Ala Asn Arg Gly Leu Ser Val
    370                 375                 380
Gln Ile Leu Ser Leu Leu Arg Lys Ala Gly Pro Ser Arg Ala Arg His
385                 390                 395                 400
Phe Ser Glu His Pro Ser Thr Ser Lys Met Asn Ala Gln Glu Thr Ala
                405                 410                 415
Thr Gly Met Ala Phe Glu Glu Pro Ile Asp Glu Lys Lys Phe Glu Lys
            420                 425                 430
Thr Glu Asp Gly Gly Glu Phe Glu Glu Gly Ala Ser Glu Asn Asn Ala
        435                 440                 445
Lys Glu Ser Ser Pro Glu Lys Glu Ala Glu Glu Gly Cys Pro Glu Lys
    450                 455                 460
Glu Ser Glu Glu Gly Cys Pro Lys Arg Gly Phe Glu Gly Ser Cys Ser
465                 470                 475                 480
Gln Lys Glu Ser Glu Glu Gly Asn Pro Val Arg Gly Ser Glu Glu Asp
                485                 490                 495
Ser Pro Lys Lys Glu Ser Lys Lys Lys Thr Leu Lys Asn Asp Cys Glu
            500                 505                 510
Glu Asn Gly Leu Ala Lys Glu Ser Glu Asp Asp Leu Asn Lys Glu Ser
        515                 520                 525
Glu Glu Glu Val Gly Pro Thr Lys Glu Ser Glu Glu Asp Asp Ser Glu
    530                 535                 540
Lys Glu Ser Asp Glu Asp Cys Ser Glu Lys Gln Ser Glu Asp Gly Ser
545                 550                 555                 560
Glu Arg Glu Phe Glu Glu Asn Gly Leu Glu Lys Asp Leu Asp Glu Glu
                565                 570                 575
Gly Ser Glu Lys Glu Leu His Glu Asn Val Leu Asp Lys Glu Leu Glu
            580                 585                 590
Glu Asn Asp Ser Glu Asn Ser Glu Phe Glu Asp Asp Gly Ser Glu Lys
        595                 600                 605
Val Leu Asp Glu Glu Gly Ser Glu Arg Glu Phe Asp Glu Asp Ser Asp
    610                 615                 620
Glu Lys Glu Glu Glu Glu Asp Thr Tyr Glu Lys Val Phe Asp Asp Glu
625                 630                 635                 640
Ser Asp Glu Lys Glu Asp Glu Glu Tyr Ala Asp Glu Lys Gly Leu Glu
                645                 650                 655
Ala Ala Asp Lys Lys Ala Glu Glu Gly Asp Ala Asp Glu Lys Leu Phe
            660                 665                 670
Glu Glu Ser Asp Asp Lys Glu Asp Glu Asp Ala Asp Gly Lys Glu Val
        675                 680                 685
Glu Asp Ala Asp Glu Lys Leu Phe Glu Asp Asp Asp Ser Asn Glu Lys
    690                 695                 700
Leu Phe Asp Glu Glu Glu Asp Ser Ser Glu Lys Leu Phe Asp Asp Ser
705                 710                 715                 720
Asp Glu Arg Gly Thr Leu Gly Gly Phe Gly Ser Val Glu Glu Gly Pro
                725                 730                 735
Leu Ser Thr Gly Ser Ser Phe Ile Leu Ser Ser Asp Asp Asp Asp Asp
            740                 745                 750
Asp Ile


<210> 552
<211> 754
<212> PRT
<213> Homo sapiens

<400> 552
Met Ser Gly Thr Asn Leu Asp Gly Asn Asp Glu Phe Asp Glu Gln Leu
 1               5                  10                  15
Arg Met Gln Glu Leu Tyr Gly Asp Gly Lys Asp Gly Asp Thr Gln Thr
            20                  25                  30
Asp Ala Gly Gly Glu Pro Asp Ser Leu Gly Gln Gln Pro Thr Asp Thr
        35                  40                  45
Pro Tyr Glu Trp Asp Leu Asp Lys Lys Ala Trp Phe Pro Lys Ile Thr
    50                  55                  60
Glu Asp Phe Ile Ala Thr Tyr Gln Ala Asn Tyr Gly Phe Ser Asn Asp
65                  70                  75                  80
Gly Ala Ser Ser Ser Thr Ala Asn Val Glu Asp Val His Ala Arg Thr
                85                  90                  95
Ala Glu Glu Pro Pro Gln Glu Lys Ala Pro Glu Pro Thr Asp Ala Arg
            100                 105                 110
Lys Lys Gly Glu Lys Arg Lys Ala Glu Ser Gly Trp Phe His Val Glu
        115                 120                 125
Glu Asp Arg Asn Thr Asn Val Tyr Val Ser Gly Leu Pro Pro Asp Ile
    130                 135                 140
Thr Val Asp Glu Phe Ile Gln Leu Met Ser Lys Phe Gly Ile Ile Met
145                 150                 155                 160
Arg Asp Pro Gln Thr Glu Glu Phe Lys Val Lys Leu Tyr Lys Asp Asn
                165                 170                 175
Gln Gly Asn Leu Lys Gly Asp Gly Leu Cys Cys Tyr Leu Lys Arg Glu
            180                 185                 190
Ser Val Glu Leu Ala Leu Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly
        195                 200                 205
Tyr Lys Leu His Val Glu Val Ala Lys Phe Gln Leu Lys Gly Glu Tyr
    210                 215                 220
Asp Ala Ser Lys Lys Lys Lys Lys Cys Lys Asp Tyr Lys Lys Lys Leu
225                 230                 235                 240
Ser Met Gln Gln Lys Gln Leu Asp Trp Arg Pro Glu Arg Arg Ala Gly
                245                 250                 255
Pro Ser Arg Met Arg His Glu Arg Val Val Ile Ile Lys Asn Met Phe
            260                 265                 270
His Pro Met Asp Phe Glu Asp Asp Pro Leu Val Leu Asn Glu Ile Arg
        275                 280                 285
Glu Asp Leu Arg Val Glu Cys Ser Lys Phe Gly Gln Ile Arg Lys Leu
    290                 295                 300
Leu Leu Phe Asp Arg His Pro Asp Gly Val Ala Ser Val Ser Phe Arg
305                 310                 315                 320
Asp Pro Glu Glu Ala Asp Tyr Cys Ile Gln Thr Leu Asp Gly Arg Trp
                325                 330                 335
Phe Gly Gly Arg Gln Ile Thr Ala Gln Ala Trp Asp Gly Thr Thr Asp
            340                 345                 350
Tyr Gln Val Glu Glu Thr Ser Arg Glu Arg Glu Glu Arg Leu Arg Gly
        355                 360                 365
Trp Glu Ala Phe Leu Asn Ala Pro Glu Ala Asn Arg Gly Leu Ser Val
    370                 375                 380
Gln Ile Leu Ser Leu Leu Arg Lys Ala Gly Pro Ser Arg Ala Arg His
385                 390                 395                 400
Phe Ser Glu His Pro Ser Thr Ser Lys Met Asn Ala Gln Glu Thr Ala
                405                 410                 415
Thr Gly Met Ala Phe Glu Glu Pro Ile Asp Glu Lys Lys Phe Glu Lys
            420                 425                 430
Thr Glu Asp Gly Gly Glu Phe Glu Glu Gly Ala Ser Glu Asn Asn Ala
        435                 440                 445
Lys Glu Ser Ser Pro Glu Lys Glu Ala Glu Glu Gly Cys Pro Glu Lys
    450                 455                 460
Glu Ser Glu Glu Gly Cys Pro Lys Arg Gly Phe Glu Gly Ser Cys Ser
465                 470                 475                 480
Gln Lys Glu Ser Glu Glu Gly Asn Pro Val Arg Gly Ser Glu Glu Asp
                485                 490                 495
Ser Pro Lys Lys Glu Ser Lys Lys Lys Thr Leu Lys Asn Asp Cys Glu
            500                 505                 510
Glu Asn Gly Leu Ala Lys Glu Ser Glu Asp Asp Leu Asn Lys Glu Ser
        515                 520                 525
Glu Glu Glu Val Gly Pro Thr Lys Glu Ser Glu Glu Asp Asp Ser Glu
    530                 535                 540
Lys Glu Ser Asp Glu Asp Cys Ser Glu Lys Gln Ser Glu Asp Gly Ser
545                 550                 555                 560
Glu Arg Glu Phe Glu Glu Asn Gly Leu Glu Lys Asp Leu Asp Glu Glu
                565                 570                 575
Gly Ser Glu Lys Glu Leu His Glu Asn Val Leu Asp Lys Glu Leu Glu
            580                 585                 590
Glu Asn Asp Ser Glu Asn Ser Glu Phe Glu Asp Asp Gly Ser Glu Lys
        595                 600                 605
Val Leu Asp Glu Glu Gly Ser Glu Arg Glu Phe Asp Glu Asp Ser Asp
    610                 615                 620
Glu Lys Glu Glu Glu Glu Asp Thr Tyr Glu Lys Val Phe Asp Asp Glu
625                 630                 635                 640
Ser Asp Glu Lys Glu Asp Glu Glu Tyr Ala Asp Glu Lys Gly Leu Glu
                645                 650                 655
Ala Ala Asp Lys Lys Ala Glu Glu Gly Asp Ala Asp Glu Lys Leu Phe
            660                 665                 670
Glu Glu Ser Asp Asp Lys Glu Asp Glu Asp Ala Asp Gly Lys Glu Val
        675                 680                 685
Glu Asp Ala Asp Glu Lys Leu Phe Glu Asp Asp Asp Ser Asn Glu Lys
    690                 695                 700
Leu Phe Asp Glu Glu Glu Asp Ser Ser Glu Lys Leu Phe Asp Asp Ser
705                 710                 715                 720
Asp Glu Arg Gly Thr Leu Gly Gly Phe Gly Ser Val Glu Glu Gly Pro
                725                 730                 735
Leu Ser Thr Gly Ser Ser Phe Ile Leu Ser Ser Asp Asp Asp Asp Asp
            740                 745                 750
Asp Ile


<210> 553
<211> 755
<212> PRT
<213> Homo sapiens

<400> 553
Met Ser Gly Thr Asn Leu Asp Gly Asn Asp Glu Phe Asp Glu Gln Leu
 1               5                  10                  15
Arg Met Gln Glu Leu Tyr Gly Asp Gly Lys Asp Gly Asp Thr Gln Thr
            20                  25                  30
Asp Ala Gly Gly Glu Pro Asp Ser Leu Gly Gln Gln Pro Thr Asp Thr
        35                  40                  45
Pro Tyr Glu Trp Asp Leu Asp Lys Lys Ala Trp Phe Pro Lys Ile Thr
    50                  55                  60
Glu Asp Phe Ile Ala Thr Tyr Gln Ala Asn Tyr Gly Phe Ser Asn Asp
65                  70                  75                  80
Gly Ala Ser Ser Ser Thr Ala Asn Val Glu Asp Val His Ala Arg Thr
                85                  90                  95
Ala Glu Glu Pro Pro Gln Glu Lys Ala Pro Glu Pro Thr Asp Ala Arg
            100                 105                 110
Lys Lys Gly Glu Lys Arg Lys Ala Glu Ser Gly Trp Phe His Val Glu
        115                 120                 125
Glu Asp Arg Asn Thr Asn Val Tyr Val Ser Gly Leu Pro Pro Asp Ile
    130                 135                 140
Thr Val Asp Glu Phe Ile Gln Leu Met Ser Lys Phe Gly Ile Ile Met
145                 150                 155                 160
Arg Asp Pro Gln Thr Glu Glu Phe Lys Val Lys Leu Tyr Lys Asp Asn
                165                 170                 175
Gln Gly Asn Leu Lys Gly Asp Gly Leu Cys Cys Tyr Leu Lys Arg Glu
            180                 185                 190
Ser Val Glu Leu Ala Leu Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly
        195                 200                 205
Tyr Lys Leu His Val Glu Val Ala Lys Phe Gln Leu Lys Gly Glu Tyr
    210                 215                 220
Asp Ala Ser Lys Lys Lys Lys Lys Cys Lys Asp Tyr Lys Lys Lys Leu
225                 230                 235                 240
Ser Met Gln Gln Lys Gln Leu Asp Trp Arg Pro Glu Arg Arg Ala Gly
                245                 250                 255
Pro Ser Arg Met Arg His Glu Arg Val Val Ile Ile Lys Asn Met Phe
            260                 265                 270
His Pro Met Asp Phe Glu Asp Asp Pro Leu Val Leu Asn Glu Ile Arg
        275                 280                 285
Glu Asp Leu Arg Val Glu Cys Ser Lys Phe Gly Gln Ile Arg Lys Leu
    290                 295                 300
Leu Leu Phe Asp Arg His Pro Asp Gly Val Ala Ser Val Ser Phe Arg
305                 310                 315                 320
Asp Pro Glu Glu Ala Asp Tyr Cys Ile Gln Thr Leu Asp Gly Arg Trp
                325                 330                 335
Phe Gly Gly Arg Gln Ile Thr Ala Gln Ala Trp Asp Gly Thr Thr Asp
            340                 345                 350
Tyr Gln Val Glu Glu Thr Ser Arg Glu Arg Glu Glu Arg Leu Arg Gly
        355                 360                 365
Trp Glu Ala Phe Leu Asn Ala Pro Glu Ala Asn Arg Gly Leu Arg Arg
    370                 375                 380
Ser Asp Ser Val Ser Ala Ser Glu Arg Ala Gly Pro Ser Arg Ala Arg
385                 390                 395                 400
His Phe Ser Glu His Pro Ser Thr Ser Lys Met Asn Ala Gln Glu Thr
                405                 410                 415
Ala Thr Gly Met Ala Phe Glu Glu Pro Ile Asp Glu Lys Lys Phe Glu
            420                 425                 430
Lys Thr Glu Asp Gly Gly Glu Phe Glu Glu Gly Ala Ser Glu Asn Asn
        435                 440                 445
Ala Lys Glu Ser Ser Pro Glu Lys Glu Ala Glu Glu Gly Cys Pro Glu
    450                 455                 460
Lys Glu Ser Glu Glu Gly Cys Pro Lys Arg Gly Phe Glu Gly Ser Cys
465                 470                 475                 480
Ser Gln Lys Glu Ser Glu Glu Gly Asn Pro Val Arg Gly Ser Glu Glu
                485                 490                 495
Asp Ser Pro Lys Lys Glu Ser Lys Lys Lys Thr Leu Lys Asn Asp Cys
            500                 505                 510
Glu Glu Asn Gly Leu Ala Lys Glu Ser Glu Asp Asp Leu Asn Lys Glu
        515                 520                 525
Ser Glu Glu Glu Val Gly Pro Thr Lys Glu Ser Glu Glu Asp Asp Ser
    530                 535                 540
Glu Lys Glu Ser Asp Glu Asp Cys Ser Glu Lys Gln Ser Glu Asp Gly
545                 550                 555                 560
Ser Glu Arg Glu Phe Glu Glu Asn Gly Leu Glu Lys Asp Leu Asp Glu
                565                 570                 575
Glu Gly Ser Glu Lys Glu Leu His Glu Asn Val Leu Asp Lys Glu Leu
            580                 585                 590
Glu Glu Asn Asp Ser Glu Asn Ser Glu Phe Glu Asp Asp Gly Ser Glu
        595                 600                 605
Lys Val Leu Asp Glu Glu Gly Ser Glu Arg Glu Phe Asp Glu Asp Ser
    610                 615                 620
Asp Glu Lys Glu Glu Glu Glu Asp Thr Tyr Glu Lys Val Phe Asp Asp
625                 630                 635                 640
Glu Ser Asp Glu Lys Glu Asp Glu Glu Tyr Ala Asp Glu Lys Gly Leu
                645                 650                 655
Glu Ala Ala Asp Lys Lys Ala Glu Glu Gly Asp Ala Asp Glu Lys Leu
            660                 665                 670
Phe Glu Glu Ser Asp Asp Lys Glu Asp Glu Asp Ala Asp Gly Lys Glu
        675                 680                 685
Val Glu Asp Ala Asp Glu Lys Leu Phe Glu Asp Asp Asp Ser Asn Glu
    690                 695                 700
Lys Leu Phe Asp Glu Glu Glu Asp Ser Ser Glu Lys Leu Phe Asp Asp
705                 710                 715                 720
Ser Asp Glu Arg Gly Thr Leu Gly Gly Phe Gly Ser Val Glu Glu Gly
                725                 730                 735
Pro Leu Ser Thr Gly Ser Ser Phe Ile Leu Ser Ser Asp Asp Asp Asp
            740                 745                 750
Asp Asp Ile
        755

<210> 554
<211> 754
<212> PRT
<213> Homo sapiens

<400> 554
Met Ser Gly Thr Asn Leu Asp Gly Asn Asp Glu Phe Asp Glu Gln Leu
 1               5                  10                  15
Arg Met Gln Glu Leu Tyr Gly Asp Gly Lys Asp Gly Asp Thr Gln Thr
            20                  25                  30
Asp Ala Gly Gly Glu Pro Asp Ser Leu Gly Gln Gln Pro Thr Asp Thr
        35                  40                  45
Pro Tyr Glu Trp Asp Leu Asp Lys Lys Ala Trp Phe Pro Lys Ile Thr
    50                  55                  60
Glu Asp Phe Ile Ala Thr Tyr Gln Ala Asn Tyr Gly Phe Ser Asn Asp
65                  70                  75                  80
Gly Ala Ser Ser Ser Thr Ala Asn Val Glu Asp Val His Ala Arg Thr
                85                  90                  95
Ala Glu Glu Pro Pro Gln Glu Lys Ala Pro Glu Pro Thr Asp Ala Arg
            100                 105                 110
Lys Lys Gly Glu Lys Arg Lys Ala Glu Ser Gly Trp Phe His Val Glu
        115                 120                 125
Glu Asp Arg Asn Thr Asn Val Tyr Val Ser Gly Leu Pro Pro Asp Ile
    130                 135                 140
Thr Val Asp Glu Phe Ile Gln Leu Met Ser Lys Phe Gly Ile Ile Met
145                 150                 155                 160
Arg Asp Pro Gln Thr Glu Glu Phe Lys Val Lys Leu Tyr Lys Asp Asn
                165                 170                 175
Gln Gly Asn Leu Lys Gly Asp Gly Leu Cys Cys Tyr Leu Lys Arg Glu
            180                 185                 190
Ser Val Glu Leu Ala Leu Lys Leu Leu Asp Glu Asp Glu Ile Arg Gly
        195                 200                 205
Tyr Lys Leu His Val Glu Val Ala Lys Phe Gln Leu Lys Gly Glu Tyr
    210                 215                 220
Asp Ala Ser Lys Lys Lys Lys Lys Cys Lys Asp Tyr Lys Lys Lys Leu
225                 230                 235                 240
Ser Met Gln Gln Lys Gln Leu Asp Trp Arg Pro Glu Arg Arg Ala Gly
                245                 250                 255
Pro Ser Arg Met Arg His Glu Arg Val Val Ile Ile Lys Asn Met Phe
            260                 265                 270
His Pro Met Asp Phe Glu Asp Asp Pro Leu Val Leu Asn Glu Ile Arg
        275                 280                 285
Glu Asp Leu Arg Val Glu Cys Ser Lys Phe Gly Gln Ile Arg Lys Leu
    290                 295                 300
Leu Leu Phe Asp Arg His Pro Asp Gly Val Ala Ser Val Ser Phe Arg
305                 310                 315                 320
Asp Pro Glu Glu Ala Asp Tyr Cys Ile Gln Thr Leu Asp Gly Arg Trp
                325                 330                 335
Phe Gly Gly Arg Gln Ile Thr Ala Gln Ala Trp Asp Gly Thr Thr Asp
            340                 345                 350
Tyr Gln Val Glu Glu Thr Ser Arg Glu Arg Glu Glu Arg Leu Arg Gly
        355                 360                 365
Trp Glu Ala Phe Leu Asn Ala Pro Glu Ala Asn Arg Gly Leu Ser Val
    370                 375                 380
Gln Ile Leu Ser Leu Leu Arg Lys Ala Gly Pro Ser Arg Ala Arg His
385                 390                 395                 400
Phe Ser Glu His Pro Ser Thr Ser Lys Met Asn Ala Gln Glu Thr Ala
                405                 410                 415
Thr Gly Met Ala Phe Glu Glu Pro Ile Asp Glu Lys Lys Phe Glu Lys
            420                 425                 430
Thr Glu Asp Gly Gly Glu Phe Glu Glu Gly Ala Ser Glu Asn Asn Ala
        435                 440                 445
Lys Glu Ser Ser Pro Glu Lys Glu Ala Glu Glu Gly Cys Pro Glu Lys
    450                 455                 460
Glu Ser Glu Glu Gly Cys Pro Lys Arg Gly Phe Glu Gly Ser Cys Ser
465                 470                 475                 480
Gln Lys Glu Ser Glu Glu Gly Asn Pro Val Arg Gly Ser Glu Glu Asp
                485                 490                 495
Ser Pro Lys Lys Glu Ser Lys Lys Lys Thr Leu Lys Asn Asp Cys Glu
            500                 505                 510
Glu Asn Gly Leu Ala Lys Glu Ser Glu Asp Asp Leu Asn Lys Glu Ser
        515                 520                 525
Glu Glu Glu Val Gly Pro Thr Lys Glu Ser Glu Glu Asp Asp Ser Glu
    530                 535                 540
Lys Glu Ser Asp Glu Asp Cys Ser Glu Lys Gln Ser Glu Asp Gly Ser
545                 550                 555                 560
Glu Arg Glu Phe Glu Glu Asn Gly Leu Glu Lys Asp Leu Asp Glu Glu
                565                 570                 575
Gly Ser Glu Lys Glu Leu His Glu Asn Val Leu Asp Lys Glu Leu Glu
            580                 585                 590
Glu Asn Asp Ser Glu Asn Ser Glu Phe Glu Asp Asp Gly Ser Glu Lys
        595                 600                 605
Val Leu Asp Glu Glu Gly Ser Glu Arg Glu Phe Asp Glu Asp Ser Asp
    610                 615                 620
Glu Lys Glu Glu Glu Glu Asp Thr Tyr Glu Lys Val Phe Asp Asp Glu
625                 630                 635                 640
Ser Asp Glu Lys Glu Asp Glu Glu Tyr Ala Asp Glu Lys Gly Leu Glu
                645                 650                 655
Ala Ala Asp Lys Lys Ala Glu Glu Gly Asp Ala Asp Glu Lys Leu Phe
            660                 665                 670
Glu Glu Ser Asp Asp Lys Glu Asp Glu Asp Ala Asp Gly Lys Glu Val
        675                 680                 685
Glu Asp Ala Asp Glu Lys Leu Phe Glu Asp Asp Asp Ser Asn Glu Lys
    690                 695                 700
Leu Phe Asp Glu Glu Glu Asp Ser Ser Glu Lys Leu Phe Asp Asp Ser
705                 710                 715                 720
Asp Glu Arg Gly Thr Leu Gly Gly Phe Gly Ser Val Glu Glu Gly Pro
                725                 730                 735
Leu Ser Thr Gly Ser Ser Phe Ile Leu Ser Ser Asp Asp Asp Asp Asp
            740                 745                 750
Asp Ile


<210> 555
<211> 765
<212> PRT
<213> Homo sapiens

<400> 555
Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln
 1               5                  10                  15
Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Arg Pro
            20                  25                  30
Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp Asn
        35                  40                  45
Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu Leu
    50                  55                  60
Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu Ala
65                  70                  75                  80
Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu Gln
                85                  90                  95
Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser Ser
            100                 105                 110
Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu Ser
        115                 120                 125
Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val Ala
    130                 135                 140
Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe Leu
145                 150                 155                 160
Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr Val
                165                 170                 175
Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro Glu
            180                 185                 190
Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile Gly
        195                 200                 205
Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val Glu
    210                 215                 220
Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys Thr
225                 230                 235                 240
Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe Gln
                245                 250                 255
Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys Ser
            260                 265                 270
Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu Leu
        275                 280                 285
Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu Ala
    290                 295                 300
Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala Pro
305                 310                 315                 320
Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro Ser
                325                 330                 335
Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp His
            340                 345                 350
Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn Val
        355                 360                 365
His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg Asp
    370                 375                 380
Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala Thr
385                 390                 395                 400
Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu Gln
                405                 410                 415
Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser Glu
            420                 425                 430
Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp Asp
        435                 440                 445
Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly Ser
    450                 455                 460
Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val Ala
465                 470                 475                 480
Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln Ala
                485                 490                 495
Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn Ile
            500                 505                 510
Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val Thr
        515                 520                 525
Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile Glu
    530                 535                 540
Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr Ala
545                 550                 555                 560
Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp Leu
                565                 570                 575
Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile Gly
            580                 585                 590
Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His Gln
        595                 600                 605
Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val Ile
    610                 615                 620
Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala
625                 630                 635                 640
Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr Ser
                645                 650                 655
Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr
            660                 665                 670
Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala Met
        675                 680                 685
Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg Pro
    690                 695                 700
Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser Leu
705                 710                 715                 720
Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala Gly
                725                 730                 735
Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys Thr
            740                 745                 750
Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His
        755                 760                 765

<210> 556
<211> 328
<212> PRT
<213> Homo sapiens

<400> 556
Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp Asp Trp Glu Ile Pro Asp
 1               5                  10                  15
Gly Gln Ile Thr Val Gly Gln Arg Ile Gly Ser Gly Ser Phe Gly Thr
            20                  25                  30
Val Tyr Lys Gly Lys Trp His Gly Asp Val Ala Val Lys Met Leu Asn
        35                  40                  45
Val Thr Ala Pro Thr Pro Gln Gln Leu Gln Ala Phe Lys Asn Glu Val
    50                  55                  60
Gly Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu Phe Met Gly
65                  70                  75                  80
Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val Thr Gln Trp Cys Glu Gly
                85                  90                  95
Ser Ser Leu Tyr His His Leu His Ile Ile Glu Thr Lys Phe Glu Met
            100                 105                 110
Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr
        115                 120                 125
Leu His Ala Lys Ser Ile Ile His Arg Asp Leu Lys Ser Asn Asn Ile
    130                 135                 140
Phe Leu His Glu Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala
145                 150                 155                 160
Thr Val Lys Ser Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu Ser
                165                 170                 175
Gly Ser Ile Leu Trp Met Ala Pro Glu Val Ile Arg Met Gln Asp Lys
            180                 185                 190
Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Phe Gly Ile Val Leu
        195                 200                 205
Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr Ser Asn Ile Asn Asn Arg
    210                 215                 220
Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser Pro Asp Leu
225                 230                 235                 240
Ser Lys Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg Leu Met Ala
                245                 250                 255
Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe Pro Gln Ile
            260                 265                 270
Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser Leu Pro Lys Ile His Arg
        275                 280                 285
Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala Gly Phe Gln Thr Glu Asp
    290                 295                 300
Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys Thr Pro Ile Gln Ala Gly
305                 310                 315                 320
Gly Tyr Gly Ala Phe Pro Val Asp
                325

<210> 557
<211> 651
<212> PRT
<213> Homo sapiens

<400> 557
Met Arg Gly Leu Ile Pro Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp
 1               5                  10                  15
Gly Pro Ser Ile Thr Asn Phe His Ile Phe Ser Met Arg Tyr Met Asn
            20                  25                  30
Ile Phe Arg Cys Asn Asn Gln Glu Arg Leu Val Ser Thr Phe Phe Arg
        35                  40                  45
Glu Lys Lys Pro Ile Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly
    50                  55                  60
Glu Glu Leu His Val Glu Val Leu Glu Asn Val Pro Leu Thr Thr His
65                  70                  75                  80
Asn Phe Val Arg Lys Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys
                85                  90                  95
Arg Lys Leu Leu Phe Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys
            100                 105                 110
Phe His Gln Arg Cys Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr
        115                 120                 125
Asp Gln Leu Asp Leu Leu Phe Val Ser Lys Phe Phe Glu His His Pro
    130                 135                 140
Ile Pro Gln Glu Glu Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly
145                 150                 155                 160
Ser Ser Pro Ser Ala Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu
                165                 170                 175
Thr Ser Pro Ser Pro Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg
            180                 185                 190
Pro Ala Asp Glu Asp His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser
        195                 200                 205
Ser Ser Ala Pro Asn Val His Ile Asn Thr Ile Glu Pro Val Asn Ile
    210                 215                 220
Asp Asp Leu Ile Arg Asp Gln Gly Phe Arg Gly Asp Gly Ala Pro Leu
225                 230                 235                 240
Asn Gln Leu Met Arg Cys Leu Arg Lys Tyr Gln Ser Arg Thr Pro Ser
                245                 250                 255
Pro Leu Leu His Ser Val Pro Ser Glu Ile Val Phe Asp Phe Glu Pro
            260                 265                 270
Gly Pro Val Phe Arg Gly Ser Thr Thr Gly Leu Ser Ala Thr Pro Pro
        275                 280                 285
Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu Gln Lys Ser
    290                 295                 300
Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser Glu Asp Arg
305                 310                 315                 320
Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp Asp Trp Glu
                325                 330                 335
Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly Ser Gly Ser
            340                 345                 350
Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val Ala Val Lys
        355                 360                 365
Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln Ala Phe Lys
    370                 375                 380
Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu
385                 390                 395                 400
Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val Thr Gln Trp
                405                 410                 415
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile Glu Thr Lys
            420                 425                 430
Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr Ala Gln Gly
        435                 440                 445
Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp Leu Lys Ser
    450                 455                 460
Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile Gly Asp Phe
465                 470                 475                 480
Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His Gln Phe Glu
                485                 490                 495
Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val Ile Arg Met
            500                 505                 510
Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Phe Gly
        515                 520                 525
Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr Ser Asn Ile
    530                 535                 540
Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
545                 550                 555                 560
Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg
                565                 570                 575
Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe
            580                 585                 590
Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser Leu Pro Lys
        595                 600                 605
Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala Gly Phe Gln
    610                 615                 620
Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys Thr Pro Ile
625                 630                 635                 640
Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His
                645                 650

<210> 558
<211> 45
<212> PRT
<213> Homo sapiens

<400> 558
Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser Pro Asp Leu Ser Lys
 1               5                  10                  15
Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg Leu Met Ala Glu Cys
            20                  25                  30
Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe Pro Gln
        35                  40                  45

<210> 559
<211> 45
<212> PRT
<213> Homo sapiens

<400> 559
Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser Pro Asp Leu Ser Lys
 1               5                  10                  15
Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg Leu Met Ala Glu Cys
            20                  25                  30
Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe Pro Gln
        35                  40                  45

<210> 560
<211> 45
<212> PRT
<213> Homo sapiens

<400> 560
Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser Pro Asp Leu Ser Lys
 1               5                  10                  15
Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg Leu Met Ala Glu Cys
            20                  25                  30
Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe Pro Gln
        35                  40                  45

<210> 561
<211> 45
<212> PRT
<213> Homo sapiens

<400> 561
Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser Pro Asp Leu Ser Lys
 1               5                  10                  15
Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg Leu Met Ala Glu Cys
            20                  25                  30
Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe Pro Gln
        35                  40                  45

<210> 562
<211> 45
<212> PRT
<213> Homo sapiens

<400> 562
Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser Pro Asp Leu Ser Lys
 1               5                  10                  15
Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg Leu Met Ala Glu Cys
            20                  25                  30
Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe Pro Gln
        35                  40                  45

<210> 563
<211> 516
<212> PRT
<213> Homo sapiens

<400> 563
Cys Glu Gly His Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn
 1               5                  10                  15
Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys
            20                  25                  30
Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln
        35                  40                  45
Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val
    50                  55                  60
Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro
65                  70                  75                  80
Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys
                85                  90                  95
Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr
            100                 105                 110
Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr
        115                 120                 125
Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Tyr Thr Gly
    130                 135                 140
Asn Gln Ile Gln Asn Arg Ile Ile Glu Ile Asn Gln Asn Gln Lys Gln
145                 150                 155                 160
Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile
                165                 170                 175
Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Lys Thr Leu Gly
            180                 185                 190
Arg Arg Asp Ser Ser Asp Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr
        195                 200                 205
Val Gly Gln Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly
    210                 215                 220
Lys Trp His Gly Asp Val Ala Val Lys Met Leu Asn Val Thr Ala Pro
225                 230                 235                 240
Thr Pro Gln Gln Leu Gln Ala Phe Lys Asn Glu Val Gly Val Leu Arg
                245                 250                 255
Lys Thr Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys
            260                 265                 270
Pro Gln Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr
        275                 280                 285
His His Leu His Ile Ile Glu Thr Lys Phe Glu Met Ile Lys Leu Ile
    290                 295                 300
Asp Ile Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys
305                 310                 315                 320
Ser Ile Ile His Arg Asp Leu Lys Ser Asn Asn Ile Phe Leu His Glu
                325                 330                 335
Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser
            340                 345                 350
Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu
        355                 360                 365
Trp Met Ala Pro Glu Val Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser
    370                 375                 380
Phe Gln Ser Asp Val Tyr Ala Phe Gly Ile Val Leu Tyr Glu Leu Met
385                 390                 395                 400
Thr Gly Gln Leu Pro Tyr Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile
                405                 410                 415
Phe Met Val Gly Arg Gly Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg
            420                 425                 430
Ser Asn Cys Pro Lys Ala Met Lys Arg Leu Met Ala Glu Cys Leu Lys
        435                 440                 445
Lys Lys Arg Asp Glu Arg Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile
    450                 455                 460
Glu Leu Leu Ala Arg Ser Leu Pro Lys Ile His Arg Ser Ala Ser Glu
465                 470                 475                 480
Pro Ser Leu Asn Arg Ala Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr
                485                 490                 495
Ala Cys Ala Ser Pro Lys Thr Pro Ile Gln Ala Gly Gly Tyr Gly Gly
            500                 505                 510
Phe Pro Val His
        515

<210> 564
<211> 650
<212> PRT
<213> Homo sapiens

<400> 564
Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu Ser Val Leu Pro
 1               5                  10                  15
Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val Ala Arg Ser Asn
            20                  25                  30
Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe Leu Pro Asn Lys
        35                  40                  45
Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr Val Arg Asp Ser
    50                  55                  60
Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro Glu Cys Cys Ala
65                  70                  75                  80
Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile Gly Trp Asp Thr
                85                  90                  95
Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val Glu Val Leu Glu
            100                 105                 110
Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys Thr Phe Phe Thr
        115                 120                 125
Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe Gln Gly Phe Arg
    130                 135                 140
Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys Ser Thr Glu Val
145                 150                 155                 160
Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu Leu Phe Val Ser
                165                 170                 175
Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu Ala Ser Leu Ala
            180                 185                 190
Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala Pro Ala Ser Asp
        195                 200                 205
Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro Ser Lys Ser Ile
    210                 215                 220
Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp His Arg Asn Gln
225                 230                 235                 240
Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn Val His Ile Asn
                245                 250                 255
Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg Asp Gln Gly Phe
            260                 265                 270
Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala Thr Pro Pro Ala
        275                 280                 285
Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu Gln Lys Ser Pro
    290                 295                 300
Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser Glu Asp Arg Asn
305                 310                 315                 320
Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp Asp Trp Glu Ile
                325                 330                 335
Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly Ser Gly Ser Phe
            340                 345                 350
Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val Ala Val Lys Met
        355                 360                 365
Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln Ala Phe Lys Asn
    370                 375                 380
Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu Phe
385                 390                 395                 400
Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val Thr Gln Trp Cys
                405                 410                 415
Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile Glu Thr Lys Phe
            420                 425                 430
Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr Ala Gln Gly Met
        435                 440                 445
Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp Leu Lys Ser Asn
    450                 455                 460
Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile Gly Asp Phe Gly
465                 470                 475                 480
Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His Gln Phe Glu Gln
                485                 490                 495
Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val Ile Arg Met Gln
            500                 505                 510
Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Phe Gly Ile
        515                 520                 525
Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr Ser Asn Ile Asn
    530                 535                 540
Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser Pro
545                 550                 555                 560
Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg Leu
                565                 570                 575
Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe Pro
            580                 585                 590
Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser Leu Pro Lys Ile
        595                 600                 605
His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala Ala Phe Gln Thr
    610                 615                 620
Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys Thr Pro Ile Gln
625                 630                 635                 640
Ala Gly Gly Tyr Gly Ala Phe Pro Val His
                645                 650

<210> 565
<211> 765
<212> PRT
<213> Homo sapiens

<400> 565
Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln
 1               5                  10                  15
Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Arg Pro
            20                  25                  30
Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp Asn
        35                  40                  45
Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu Leu
    50                  55                  60
Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu Ala
65                  70                  75                  80
Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu Gln
                85                  90                  95
Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser Ser
            100                 105                 110
Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu Ser
        115                 120                 125
Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val Ala
    130                 135                 140
Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe Leu
145                 150                 155                 160
Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr Val
                165                 170                 175
Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro Glu
            180                 185                 190
Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile Gly
        195                 200                 205
Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val Glu
    210                 215                 220
Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys Thr
225                 230                 235                 240
Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe Gln
                245                 250                 255
Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys Ser
            260                 265                 270
Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu Leu
        275                 280                 285
Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu Ala
    290                 295                 300
Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala Pro
305                 310                 315                 320
Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro Ser
                325                 330                 335
Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp His
            340                 345                 350
Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn Val
        355                 360                 365
His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg Asp
    370                 375                 380
Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala Thr
385                 390                 395                 400
Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu Gln
                405                 410                 415
Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser Glu
            420                 425                 430
Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp Asp
        435                 440                 445
Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly Ser
    450                 455                 460
Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val Ala
465                 470                 475                 480
Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln Ala
                485                 490                 495
Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn Ile
            500                 505                 510
Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val Thr
        515                 520                 525
Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile Glu
    530                 535                 540
Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr Ala
545                 550                 555                 560
Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp Leu
                565                 570                 575
Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile Gly
            580                 585                 590
Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His Gln
        595                 600                 605
Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val Ile
    610                 615                 620
Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala
625                 630                 635                 640
Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr Ser
                645                 650                 655
Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr
            660                 665                 670
Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala Met
        675                 680                 685
Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg Pro
    690                 695                 700
Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser Leu
705                 710                 715                 720
Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala Gly
                725                 730                 735
Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys Thr
            740                 745                 750
Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His
        755                 760                 765

<210> 566
<211> 765
<212> PRT
<213> Homo sapiens

<400> 566
Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln
 1               5                  10                  15
Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Arg Pro
            20                  25                  30
Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp Asn
        35                  40                  45
Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu Leu
    50                  55                  60
Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu Ala
65                  70                  75                  80
Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu Gln
                85                  90                  95
Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser Ser
            100                 105                 110
Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu Ser
        115                 120                 125
Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val Ala
    130                 135                 140
Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe Leu
145                 150                 155                 160
Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr Val
                165                 170                 175
Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro Glu
            180                 185                 190
Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile Gly
        195                 200                 205
Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val Glu
    210                 215                 220
Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys Thr
225                 230                 235                 240
Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe Gln
                245                 250                 255
Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys Ser
            260                 265                 270
Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu Leu
        275                 280                 285
Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu Ala
    290                 295                 300
Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala Pro
305                 310                 315                 320
Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro Ser
                325                 330                 335
Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp His
            340                 345                 350
Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn Val
        355                 360                 365
His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg Asp
    370                 375                 380
Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala Thr
385                 390                 395                 400
Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu Gln
                405                 410                 415
Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser Glu
            420                 425                 430
Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp Asp
        435                 440                 445
Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly Ser
    450                 455                 460
Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val Ala
465                 470                 475                 480
Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln Ala
                485                 490                 495
Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn Ile
            500                 505                 510
Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val Thr
        515                 520                 525
Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile Glu
    530                 535                 540
Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr Ala
545                 550                 555                 560
Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp Leu
                565                 570                 575
Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile Gly
            580                 585                 590
Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His Gln
        595                 600                 605
Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val Ile
    610                 615                 620
Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala
625                 630                 635                 640
Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr Ser
                645                 650                 655
Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr
            660                 665                 670
Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala Met
        675                 680                 685
Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg Pro
    690                 695                 700
Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser Leu
705                 710                 715                 720
Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala Gly
                725                 730                 735
Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys Thr
            740                 745                 750
Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His
        755                 760                 765

<210> 567
<211> 651
<212> PRT
<213> Homo sapiens

<400> 567
Met Arg Gly Leu Ile Pro Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp
 1               5                  10                  15
Gly Pro Ser Ile Thr Asn Phe His Ile Phe Ser Met Arg Tyr Met Asn
            20                  25                  30
Ile Phe Arg Cys Asn Asn Gln Glu Arg Leu Val Ser Thr Phe Phe Arg
        35                  40                  45
Glu Lys Lys Pro Ile Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly
    50                  55                  60
Glu Glu Leu His Val Glu Val Leu Glu Asn Val Pro Leu Thr Thr His
65                  70                  75                  80
Asn Phe Val Arg Lys Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys
                85                  90                  95
Arg Lys Leu Leu Phe Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys
            100                 105                 110
Phe His Gln Arg Cys Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr
        115                 120                 125
Asp Gln Leu Asp Leu Leu Phe Val Ser Lys Phe Phe Glu His His Pro
    130                 135                 140
Ile Pro Gln Glu Glu Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly
145                 150                 155                 160
Ser Ser Pro Ser Ala Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu
                165                 170                 175
Thr Ser Pro Ser Pro Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg
            180                 185                 190
Pro Ala Asp Glu Asp His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser
        195                 200                 205
Ser Ser Ala Pro Asn Val His Ile Asn Thr Ile Glu Pro Val Asn Ile
    210                 215                 220
Asp Asp Leu Ile Arg Asp Gln Gly Phe Arg Gly Asp Gly Ala Pro Leu
225                 230                 235                 240
Asn Gln Leu Met Arg Cys Leu Arg Lys Tyr Gln Ser Arg Thr Pro Ser
                245                 250                 255
Pro Leu Leu His Ser Val Pro Ser Glu Ile Val Phe Asp Phe Glu Pro
            260                 265                 270
Gly Pro Val Phe Arg Gly Ser Thr Thr Gly Leu Ser Ala Thr Pro Pro
        275                 280                 285
Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu Gln Lys Ser
    290                 295                 300
Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser Glu Asp Arg
305                 310                 315                 320
Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp Asp Trp Glu
                325                 330                 335
Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly Ser Gly Ser
            340                 345                 350
Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val Ala Val Lys
        355                 360                 365
Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln Ala Phe Lys
    370                 375                 380
Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu
385                 390                 395                 400
Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val Thr Gln Trp
                405                 410                 415
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile Glu Thr Lys
            420                 425                 430
Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr Ala Gln Gly
        435                 440                 445
Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp Leu Lys Ser
    450                 455                 460
Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile Gly Asp Phe
465                 470                 475                 480
Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His Gln Phe Glu
                485                 490                 495
Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val Ile Arg Met
            500                 505                 510
Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Phe Gly
        515                 520                 525
Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr Ser Asn Ile
    530                 535                 540
Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
545                 550                 555                 560
Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala Met Lys Arg
                565                 570                 575
Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg Pro Leu Phe
            580                 585                 590
Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser Leu Pro Lys
        595                 600                 605
Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala Gly Phe Gln
    610                 615                 620
Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys Thr Pro Ile
625                 630                 635                 640
Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His
                645                 650

<210> 568
<211> 4128
<212> PRT
<213> Homo sapiens

<400> 568
Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
 1               5                  10                  15
Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
            20                  25                  30
Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
        35                  40                  45
Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
    50                  55                  60
Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
65                  70                  75                  80
Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                85                  90                  95
Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
            100                 105                 110
Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
        115                 120                 125
Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
    130                 135                 140
Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
145                 150                 155                 160
Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                165                 170                 175
Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
            180                 185                 190
Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
        195                 200                 205
Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
    210                 215                 220
Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
225                 230                 235                 240
Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                245                 250                 255
Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
            260                 265                 270
Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
        275                 280                 285
Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
    290                 295                 300
Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
305                 310                 315                 320
Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                325                 330                 335
Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
            340                 345                 350
Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
        355                 360                 365
Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
    370                 375                 380
Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
385                 390                 395                 400
Asp Thr Gly Asp Asp Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                405                 410                 415
Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
            420                 425                 430
Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
        435                 440                 445
Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
    450                 455                 460
Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
465                 470                 475                 480
Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                485                 490                 495
Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
            500                 505                 510
Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
        515                 520                 525
Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
    530                 535                 540
Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
545                 550                 555                 560
Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                565                 570                 575
Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
            580                 585                 590
Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
        595                 600                 605
Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
    610                 615                 620
Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
625                 630                 635                 640
Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                645                 650                 655
Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
            660                 665                 670
Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
        675                 680                 685
Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
    690                 695                 700
Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
705                 710                 715                 720
Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                725                 730                 735
Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
            740                 745                 750
Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
        755                 760                 765
Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
    770                 775                 780
Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
785                 790                 795                 800
Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                805                 810                 815
Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
            820                 825                 830
His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
        835                 840                 845
Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
    850                 855                 860
Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
865                 870                 875                 880
Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                885                 890                 895
Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
            900                 905                 910
Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
        915                 920                 925
Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
    930                 935                 940
Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
945                 950                 955                 960
Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                965                 970                 975
Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
            980                 985                 990
His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ala
        995                 1000                1005
Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020
Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055
Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070
Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085
Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100
Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135
Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150
Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165
Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180
His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215
Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230
Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245
Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260
Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295
Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310
Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325
Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340
Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375
Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390
Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405
Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420
Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455
Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470
Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485
Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500
Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535
Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550
Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565
Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580
Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615
Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630
Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645
Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660
His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695
Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710
Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725
Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740
Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760
Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775
Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790
Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805
Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820
Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840
Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855
Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870
Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885
Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900
Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920
Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935
Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950
Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965
Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980
Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000
Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015
Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030
Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045
Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060
Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080
Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095
Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110
Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125
Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140
Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160
Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175
Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190
Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205
Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220
His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240
Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255
Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270
Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285
Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300
Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320
Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335
Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350
Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365
Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380
Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400
Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415
Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
            2420                2425                2430
Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
        2435                2440                2445
Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
    2450                2455                2460
Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
2465                2470                2475                2480
His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                2485                2490                2495
Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
            2500                2505                2510
Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
        2515                2520                2525
Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
    2530                2535                2540
Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
2545                2550                2555                2560
Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                2565                2570                2575
Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
            2580                2585                2590
Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
        2595                2600                2605
Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
    2610                2615                2620
Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
2625                2630                2635                2640
Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                2645                2650                2655
Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
            2660                2665                2670
Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
        2675                2680                2685
Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
    2690                2695                2700
Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
2705                2710                2715                2720
Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                2725                2730                2735
Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
            2740                2745                2750
Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
        2755                2760                2765
Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
    2770                2775                2780
Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
2785                2790                2795                2800
Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                2805                2810                2815
Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
            2820                2825                2830
Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
        2835                2840                2845
Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
    2850                2855                2860
His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
2865                2870                2875                2880
Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                2885                2890                2895
Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
            2900                2905                2910
Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
        2915                2920                2925
Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
    2930                2935                2940
Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
2945                2950                2955                2960
Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                2965                2970                2975
Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
            2980                2985                2990
Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
        2995                3000                3005
Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
    3010                3015                3020
Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
3025                3030                3035                3040
Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                3045                3050                3055
Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
            3060                3065                3070
Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
        3075                3080                3085
Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
    3090                3095                3100
Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
3105                3110                3115                3120
Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                3125                3130                3135
Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
            3140                3145                3150
Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
        3155                3160                3165
Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
    3170                3175                3180
Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
3185                3190                3195                3200
Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                3205                3210                3215
Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
            3220                3225                3230
Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
        3235                3240                3245
Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
    3250                3255                3260
Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
3265                3270                3275                3280
Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                3285                3290                3295
Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
            3300                3305                3310
Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
        3315                3320                3325
Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
    3330                3335                3340
Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
3345                3350                3355                3360
Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                3365                3370                3375
Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
            3380                3385                3390
Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
        3395                3400                3405
Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
    3410                3415                3420
Arg Lys Glu Glu Glu Asn Ala Ser Val Ile Asp Ser Ala Glu Leu Gln
3425                3430                3435                3440
Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                3445                3450                3455
Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
            3460                3465                3470
Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
        3475                3480                3485
Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
    3490                3495                3500
Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
3505                3510                3515                3520
Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                3525                3530                3535
Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
            3540                3545                3550
Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
        3555                3560                3565
Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
    3570                3575                3580
Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
3585                3590                3595                3600
Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                3605                3610                3615
Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
            3620                3625                3630
Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
        3635                3640                3645
Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
    3650                3655                3660
Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
3665                3670                3675                3680
Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                3685                3690                3695
Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
            3700                3705                3710
Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
        3715                3720                3725
Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
    3730                3735                3740
Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
3745                3750                3755                3760
Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                3765                3770                3775
Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
            3780                3785                3790
Val Val Pro Met Thr Ser Arg Leu Gly Leu Ile Glu Trp Leu Glu Asn
        3795                3800                3805
Thr Val Thr Leu Lys Asp Leu Leu Leu Asn Thr Met Ser Gln Glu Glu
    3810                3815                3820
Lys Ala Ala Tyr Leu Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr Lys
3825                3830                3835                3840
Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr Met
                3845                3850                3855
Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe Arg
            3860                3865                3870
Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe Val
        3875                3880                3885
Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His Phe
    3890                3895                3900
Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly Ile
3905                3910                3915                3920
Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly Gly
                3925                3930                3935
Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln Phe
            3940                3945                3950
Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe Ile
        3955                3960                3965
Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile Met
    3970                3975                3980
Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr Asn
3985                3990                3995                4000
Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn Phe
                4005                4010                4015
Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile Asn
            4020                4025                4030
Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala Lys
        4035                4040                4045
Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu Leu
    4050                4055                4060
Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala Val
4065                4070                4075                4080
Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu Ser
                4085                4090                4095
Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala Thr
            4100                4105                4110
Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp Met
        4115                4120                4125

<210> 569
<211> 4097
<212> PRT
<213> Homo sapiens

<400> 569
Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
 1               5                  10                  15
Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
            20                  25                  30
Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
        35                  40                  45
Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
    50                  55                  60
Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
65                  70                  75                  80
Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                85                  90                  95
Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
            100                 105                 110
Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
        115                 120                 125
Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
    130                 135                 140
Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
145                 150                 155                 160
Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                165                 170                 175
Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
            180                 185                 190
Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
        195                 200                 205
Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
    210                 215                 220
Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
225                 230                 235                 240
Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                245                 250                 255
Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
            260                 265                 270
Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
        275                 280                 285
Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
    290                 295                 300
Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
305                 310                 315                 320
Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                325                 330                 335
Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
            340                 345                 350
Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
        355                 360                 365
Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
    370                 375                 380
Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
385                 390                 395                 400
Asp Thr Gly Asp Tyr Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                405                 410                 415
Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
            420                 425                 430
Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
        435                 440                 445
Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
    450                 455                 460
Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
465                 470                 475                 480
Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                485                 490                 495
Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
            500                 505                 510
Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
        515                 520                 525
Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
    530                 535                 540
Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
545                 550                 555                 560
Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                565                 570                 575
Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
            580                 585                 590
Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
        595                 600                 605
Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
    610                 615                 620
Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
625                 630                 635                 640
Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                645                 650                 655
Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
            660                 665                 670
Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
        675                 680                 685
Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
    690                 695                 700
Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
705                 710                 715                 720
Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                725                 730                 735
Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
            740                 745                 750
Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
        755                 760                 765
Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
    770                 775                 780
Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
785                 790                 795                 800
Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                805                 810                 815
Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
            820                 825                 830
His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
        835                 840                 845
Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
    850                 855                 860
Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
865                 870                 875                 880
Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                885                 890                 895
Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
            900                 905                 910
Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
        915                 920                 925
Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
    930                 935                 940
Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
945                 950                 955                 960
Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                965                 970                 975
Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
            980                 985                 990
His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ser
        995                 1000                1005
Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020
Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055
Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070
Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085
Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100
Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135
Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150
Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165
Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180
His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215
Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230
Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245
Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260
Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295
Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310
Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325
Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340
Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375
Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390
Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405
Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420
Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455
Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470
Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485
Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500
Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535
Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550
Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565
Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580
Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615
Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630
Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645
Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660
His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695
Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710
Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725
Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740
Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760
Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775
Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790
Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805
Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820
Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840
Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855
Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870
Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885
Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900
Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920
Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935
Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950
Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965
Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980
Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000
Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015
Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030
Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045
Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060
Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080
Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095
Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110
Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125
Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140
Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160
Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175
Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190
Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205
Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220
His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240
Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255
Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270
Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285
Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300
Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320
Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335
Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350
Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365
Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380
Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400
Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415
Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
            2420                2425                2430
Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
        2435                2440                2445
Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
    2450                2455                2460
Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
2465                2470                2475                2480
His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                2485                2490                2495
Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
            2500                2505                2510
Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
        2515                2520                2525
Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
    2530                2535                2540
Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
2545                2550                2555                2560
Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                2565                2570                2575
Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
            2580                2585                2590
Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
        2595                2600                2605
Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
    2610                2615                2620
Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
2625                2630                2635                2640
Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                2645                2650                2655
Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
            2660                2665                2670
Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
        2675                2680                2685
Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
    2690                2695                2700
Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
2705                2710                2715                2720
Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                2725                2730                2735
Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
            2740                2745                2750
Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
        2755                2760                2765
Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
    2770                2775                2780
Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
2785                2790                2795                2800
Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                2805                2810                2815
Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
            2820                2825                2830
Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
        2835                2840                2845
Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
    2850                2855                2860
His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
2865                2870                2875                2880
Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                2885                2890                2895
Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
            2900                2905                2910
Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
        2915                2920                2925
Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
    2930                2935                2940
Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
2945                2950                2955                2960
Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                2965                2970                2975
Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
            2980                2985                2990
Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
        2995                3000                3005
Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
    3010                3015                3020
Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
3025                3030                3035                3040
Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                3045                3050                3055
Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
            3060                3065                3070
Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
        3075                3080                3085
Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
    3090                3095                3100
Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
3105                3110                3115                3120
Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                3125                3130                3135
Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
            3140                3145                3150
Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
        3155                3160                3165
Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
    3170                3175                3180
Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
3185                3190                3195                3200
Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                3205                3210                3215
Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
            3220                3225                3230
Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
        3235                3240                3245
Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
    3250                3255                3260
Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
3265                3270                3275                3280
Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                3285                3290                3295
Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
            3300                3305                3310
Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
        3315                3320                3325
Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
    3330                3335                3340
Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
3345                3350                3355                3360
Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                3365                3370                3375
Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
            3380                3385                3390
Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
        3395                3400                3405
Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
    3410                3415                3420
Arg Lys Glu Glu Glu Asn Ala Ser Val Ile Asp Ser Ala Glu Leu Gln
3425                3430                3435                3440
Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                3445                3450                3455
Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
            3460                3465                3470
Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
        3475                3480                3485
Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
    3490                3495                3500
Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
3505                3510                3515                3520
Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                3525                3530                3535
Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
            3540                3545                3550
Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
        3555                3560                3565
Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
    3570                3575                3580
Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
3585                3590                3595                3600
Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                3605                3610                3615
Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
            3620                3625                3630
Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
        3635                3640                3645
Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
    3650                3655                3660
Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
3665                3670                3675                3680
Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                3685                3690                3695
Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
            3700                3705                3710
Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
        3715                3720                3725
Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
    3730                3735                3740
Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
3745                3750                3755                3760
Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                3765                3770                3775
Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
            3780                3785                3790
Val Val Pro Met Thr Ser Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr
        3795                3800                3805
Lys Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr
    3810                3815                3820
Met Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe
3825                3830                3835                3840
Arg Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe
                3845                3850                3855
Val Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His
            3860                3865                3870
Phe Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly
        3875                3880                3885
Ile Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly
    3890                3895                3900
Gly Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln
3905                3910                3915                3920
Phe Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe
                3925                3930                3935
Ile Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile
            3940                3945                3950
Met Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr
        3955                3960                3965
Asn Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn
    3970                3975                3980
Phe Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile
3985                3990                3995                4000
Asn Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala
                4005                4010                4015
Lys Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu
            4020                4025                4030
Leu Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala
        4035                4040                4045
Val Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu
    4050                4055                4060
Ser Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala
4065                4070                4075                4080
Thr Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp
                4085                4090                4095
Met


<210> 570
<211> 1689
<212> PRT
<213> Homo sapiens

<400> 570
Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
 1               5                  10                  15
Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
            20                  25                  30
Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
        35                  40                  45
Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
    50                  55                  60
Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
65                  70                  75                  80
Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                85                  90                  95
Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
            100                 105                 110
Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
        115                 120                 125
Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
    130                 135                 140
Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
145                 150                 155                 160
Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                165                 170                 175
Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
            180                 185                 190
Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
        195                 200                 205
Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
    210                 215                 220
Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
225                 230                 235                 240
Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                245                 250                 255
Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
            260                 265                 270
Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
        275                 280                 285
Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
    290                 295                 300
Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
305                 310                 315                 320
Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                325                 330                 335
Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
            340                 345                 350
Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
        355                 360                 365
Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
    370                 375                 380
Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
385                 390                 395                 400
Asp Thr Gly Asp Asp Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                405                 410                 415
Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
            420                 425                 430
Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
        435                 440                 445
Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
    450                 455                 460
Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
465                 470                 475                 480
Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                485                 490                 495
Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
            500                 505                 510
Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
        515                 520                 525
Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
    530                 535                 540
Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
545                 550                 555                 560
Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                565                 570                 575
Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
            580                 585                 590
Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
        595                 600                 605
Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
    610                 615                 620
Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
625                 630                 635                 640
Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                645                 650                 655
Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
            660                 665                 670
Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
        675                 680                 685
Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
    690                 695                 700
Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
705                 710                 715                 720
Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                725                 730                 735
Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
            740                 745                 750
Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
        755                 760                 765
Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
    770                 775                 780
Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
785                 790                 795                 800
Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                805                 810                 815
Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
            820                 825                 830
His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
        835                 840                 845
Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
    850                 855                 860
Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
865                 870                 875                 880
Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                885                 890                 895
Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
            900                 905                 910
Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
        915                 920                 925
Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
    930                 935                 940
Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
945                 950                 955                 960
Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                965                 970                 975
Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
            980                 985                 990
His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ala
        995                 1000                1005
Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020
Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055
Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070
Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085
Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100
Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135
Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150
Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165
Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180
His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215
Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230
Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245
Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260
Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295
Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310
Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325
Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340
Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375
Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390
Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405
Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420
Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455
Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470
Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485
Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500
Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535
Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550
Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565
Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580
Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615
Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630
Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645
Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660
His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
Asp Thr Lys Leu Asp Leu His Leu Lys
                1685

<210> 571
<211> 4096
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(4096)
<223> Xaa = Any Amino Acid

<400> 571
Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
 1               5                  10                  15
Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
            20                  25                  30
Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
        35                  40                  45
Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
    50                  55                  60
Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
65                  70                  75                  80
Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                85                  90                  95
Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
            100                 105                 110
Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
        115                 120                 125
Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
    130                 135                 140
Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
145                 150                 155                 160
Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                165                 170                 175
Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
            180                 185                 190
Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
        195                 200                 205
Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
    210                 215                 220
Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
225                 230                 235                 240
Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                245                 250                 255
Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
            260                 265                 270
Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
        275                 280                 285
Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
    290                 295                 300
Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
305                 310                 315                 320
Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                325                 330                 335
Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
            340                 345                 350
Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
        355                 360                 365
Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
    370                 375                 380
Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
385                 390                 395                 400
Asp Thr Gly Asp Tyr Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                405                 410                 415
Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
            420                 425                 430
Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
        435                 440                 445
Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
    450                 455                 460
Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
465                 470                 475                 480
Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                485                 490                 495
Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
            500                 505                 510
Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
        515                 520                 525
Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
    530                 535                 540
Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
545                 550                 555                 560
Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                565                 570                 575
Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
            580                 585                 590
Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
        595                 600                 605
Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
    610                 615                 620
Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
625                 630                 635                 640
Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                645                 650                 655
Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
            660                 665                 670
Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
        675                 680                 685
Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
    690                 695                 700
Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
705                 710                 715                 720
Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                725                 730                 735
Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
            740                 745                 750
Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
        755                 760                 765
Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
    770                 775                 780
Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
785                 790                 795                 800
Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                805                 810                 815
Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
            820                 825                 830
His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
        835                 840                 845
Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
    850                 855                 860
Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
865                 870                 875                 880
Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                885                 890                 895
Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
            900                 905                 910
Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
        915                 920                 925
Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
    930                 935                 940
Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
945                 950                 955                 960
Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                965                 970                 975
Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
            980                 985                 990
His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ser
        995                 1000                1005
Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020
Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055
Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070
Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085
Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100
Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135
Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150
Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165
Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180
His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215
Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230
Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245
Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260
Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295
Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310
Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325
Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340
Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375
Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390
Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405
Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420
Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455
Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470
Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485
Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500
Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535
Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550
Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565
Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580
Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615
Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630
Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645
Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660
His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695
Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710
Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725
Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740
Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760
Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775
Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790
Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805
Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820
Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840
Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855
Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870
Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885
Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900
Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920
Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935
Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950
Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965
Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980
Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000
Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015
Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030
Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045
Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060
Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080
Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095
Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110
Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125
Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140
Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160
Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175
Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190
Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205
Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220
His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240
Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255
Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270
Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285
Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300
Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320
Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335
Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350
Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365
Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380
Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400
Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415
Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Glu Arg Gln Lys
            2420                2425                2430
Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro Val
        2435                2440                2445
Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His Pro
    2450                2455                2460
Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile His
2465                2470                2475                2480
Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln Glu
                2485                2490                2495
Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp Glu
            2500                2505                2510
Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu Thr
        2515                2520                2525
Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser Leu
    2530                2535                2540
Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn Phe
2545                2550                2555                2560
Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met Phe
                2565                2570                2575
Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp Ser
            2580                2585                2590
Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu Thr
        2595                2600                2605
Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser Leu
    2610                2615                2620
Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln Gln
2625                2630                2635                2640
His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe Asp
                2645                2650                2655
Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser Pro
            2660                2665                2670
Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu Gln
        2675                2680                2685
Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg Leu
    2690                2695                2700
Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala Gly
2705                2710                2715                2720
Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln Glu
                2725                2730                2735
Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys Arg
            2740                2745                2750
Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln Val
        2755                2760                2765
Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln Ile
    2770                2775                2780
Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg Asp
2785                2790                2795                2800
Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile Leu
                2805                2810                2815
Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile Thr
            2820                2825                2830
Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe Ser
        2835                2840                2845
Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln His
    2850                2855                2860
Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys Leu
2865                2870                2875                2880
Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala Leu
                2885                2890                2895
Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly Lys
            2900                2905                2910
Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys Leu
        2915                2920                2925
Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr Ser
    2930                2935                2940
Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu Ala
2945                2950                2955                2960
Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu Asn
                2965                2970                2975
Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp Phe
            2980                2985                2990
Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp Lys
        2995                3000                3005
Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro Pro
    3010                3015                3020
Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr Leu
3025                3030                3035                3040
Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu Ala
                3045                3050                3055
Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu Leu
            3060                3065                3070
Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu Leu
        3075                3080                3085
Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln Asn
    3090                3095                3100
Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu Leu
3105                3110                3115                3120
His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr Glu
                3125                3130                3135
Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser Ser
            3140                3145                3150
Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr Pro
        3155                3160                3165
Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr Asn
    3170                3175                3180
Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu Pro
3185                3190                3195                3200
Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp Arg
                3205                3210                3215
Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg Ser
            3220                3225                3230
Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys Gln
        3235                3240                3245
Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys Glu
    3250                3255                3260
Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr Cys
3265                3270                3275                3280
Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln Val
                3285                3290                3295
Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val Ser
            3300                3305                3310
Ser Tyr Leu Xaa Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile Leu
        3315                3320                3325
Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu Pro
    3330                3335                3340
Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu Glu
3345                3350                3355                3360
Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly Leu
                3365                3370                3375
Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala Glu
            3380                3385                3390
Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly Val
        3395                3400                3405
Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu Arg
    3410                3415                3420
Lys Glu Glu Glu Asn Ala Ser Val Thr Asp Ser Ala Glu Leu Gln Ala
3425                3430                3435                3440
Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu Asn
                3445                3450                3455
Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile Glu
            3460                3465                3470
Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser Ser
        3475                3480                3485
Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala Leu
    3490                3495                3500
Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu Ile
3505                3510                3515                3520
Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser Ser
                3525                3530                3535
Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys Glu
            3540                3545                3550
Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile Gln
        3555                3560                3565
Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu Phe
    3570                3575                3580
Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro Val
3585                3590                3595                3600
Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala Leu
                3605                3610                3615
Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe Ile
            3620                3625                3630
Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly Ser
        3635                3640                3645
Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn Met
    3650                3655                3660
Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu Lys
3665                3670                3675                3680
Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg Asn
                3685                3690                3695
Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu Pro
            3700                3705                3710
Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val Met
        3715                3720                3725
Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp Glu
    3730                3735                3740
Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln Asp
3745                3750                3755                3760
Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala Gln
                3765                3770                3775
Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser Val
            3780                3785                3790
Val Pro Met Thr Ser Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr Lys
        3795                3800                3805
Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr Met
    3810                3815                3820
Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe Arg
3825                3830                3835                3840
Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe Val
                3845                3850                3855
Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His Phe
            3860                3865                3870
Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly Ile
        3875                3880                3885
Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly Gly
    3890                3895                3900
Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln Phe
3905                3910                3915                3920
Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe Ile
                3925                3930                3935
Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile Met
            3940                3945                3950
Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr Asn
        3955                3960                3965
Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn Phe
    3970                3975                3980
Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile Asn
3985                3990                3995                4000
Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala Lys
                4005                4010                4015
Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu Leu
            4020                4025                4030
Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala Val
        4035                4040                4045
Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu Ser
    4050                4055                4060
Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala Thr
4065                4070                4075                4080
Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp Met
                4085                4090                4095

<210> 572
<211> 4095
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(4095)
<223> Xaa = Any Amino Acid

<400> 572
Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
 1               5                  10                  15
Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
            20                  25                  30
Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
        35                  40                  45
Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
    50                  55                  60
Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
65                  70                  75                  80
Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Arg Met
                85                  90                  95
Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
            100                 105                 110
Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
        115                 120                 125
Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
    130                 135                 140
Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
145                 150                 155                 160
Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                165                 170                 175
Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
            180                 185                 190
Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
        195                 200                 205
Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
    210                 215                 220
Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
225                 230                 235                 240
Asp Pro Gly Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                245                 250                 255
Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
            260                 265                 270
Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
        275                 280                 285
Asn Tyr Val Ser Leu Phe Glu Val Leu Ile Lys Trp Cys Ala His Thr
    290                 295                 300
Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
305                 310                 315                 320
Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                325                 330                 335
Lys Leu Gln Tyr Glu Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
            340                 345                 350
Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
        355                 360                 365
Phe Ala Gly Pro Ala Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
    370                 375                 380
Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
385                 390                 395                 400
Asp Thr Gly Asp Tyr Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                405                 410                 415
Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
            420                 425                 430
Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
        435                 440                 445
Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
    450                 455                 460
Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
465                 470                 475                 480
Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ala Lys Pro Val Val
                485                 490                 495
Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
            500                 505                 510
Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
        515                 520                 525
Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
    530                 535                 540
Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
545                 550                 555                 560
Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                565                 570                 575
Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
            580                 585                 590
Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Glu Asp Pro
        595                 600                 605
Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
    610                 615                 620
Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
625                 630                 635                 640
Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                645                 650                 655
Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
            660                 665                 670
Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
        675                 680                 685
Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
    690                 695                 700
Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
705                 710                 715                 720
Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                725                 730                 735
Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
            740                 745                 750
Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
        755                 760                 765
Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
    770                 775                 780
Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
785                 790                 795                 800
Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                805                 810                 815
Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
            820                 825                 830
His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
        835                 840                 845
Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
    850                 855                 860
Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
865                 870                 875                 880
Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                885                 890                 895
Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
            900                 905                 910
Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
        915                 920                 925
Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
    930                 935                 940
Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
945                 950                 955                 960
Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                965                 970                 975
Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
            980                 985                 990
His Trp Phe Thr Asn Asn His Lys Phe Glu Ser Gln Asp Thr Val Ser
        995                 1000                1005
Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020
Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055
Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070
Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085
Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100
Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135
Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150
Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165
Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180
His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215
Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230
Ser Gly Ile Leu Ala Gly Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245
Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260
Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295
Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310
Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325
Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340
Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375
Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390
Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405
Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420
Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455
Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470
Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485
Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500
Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535
Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550
Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565
Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580
Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615
Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630
Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645
Leu Ala Lys Ile Leu Gly Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660
His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695
Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710
Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725
Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740
Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760
Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775
Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790
Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805
Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820
Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840
Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855
Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870
Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885
Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900
Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920
Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935
Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950
Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965
Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980
Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000
Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015
Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030
Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045
Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060
Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080
Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095
Leu Thr Ala Leu Val Lys His Met Asx Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110
Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125
Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140
Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160
Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175
Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190
Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205
Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220
His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240
Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255
Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270
Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285
Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300
Asn Asn Met Glu Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320
Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335
Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350
Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365
Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380
Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400
Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415
Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Glu Arg Gln Lys
            2420                2425                2430
Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro Val
        2435                2440                2445
Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His Pro
    2450                2455                2460
Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile His
2465                2470                2475                2480
Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln Glu
                2485                2490                2495
Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp Glu
            2500                2505                2510
Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu Thr
        2515                2520                2525
Arg Leu Pro Glu Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser Leu
    2530                2535                2540
Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn Phe
2545                2550                2555                2560
Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met Phe
                2565                2570                2575
Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp Ser
            2580                2585                2590
Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu Thr
        2595                2600                2605
Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser Leu
    2610                2615                2620
Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln Gln
2625                2630                2635                2640
His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe Asp
                2645                2650                2655
Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser Pro
            2660                2665                2670
Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu Gln
        2675                2680                2685
Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg Leu
    2690                2695                2700
Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala Gly
2705                2710                2715                2720
Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln Glu
                2725                2730                2735
Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys Arg
            2740                2745                2750
Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gly Val
        2755                2760                2765
Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln Ile
    2770                2775                2780
Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg Asp
2785                2790                2795                2800
Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile Leu
                2805                2810                2815
Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile Thr
            2820                2825                2830
Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe Ser
        2835                2840                2845
Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln His
    2850                2855                2860
Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys Leu
2865                2870                2875                2880
Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala Leu
                2885                2890                2895
Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly Lys
            2900                2905                2910
Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys Leu
        2915                2920                2925
Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr Ser
    2930                2935                2940
Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu Ala
2945                2950                2955                2960
Arg Ser Asp Tyr Ser Glu Ser Ala Lys Gln Tyr Asp Glu Ala Leu Asn
                2965                2970                2975
Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp Phe
            2980                2985                2990
Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp Lys
        2995                3000                3005
Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro Pro
    3010                3015                3020
Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr Leu
3025                3030                3035                3040
Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu Ala
                3045                3050                3055
Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu Leu
            3060                3065                3070
Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu Leu
        3075                3080                3085
Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gly Asn
    3090                3095                3100
Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu Leu
3105                3110                3115                3120
His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr Glu
                3125                3130                3135
Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser Glu
            3140                3145                3150
Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr Pro
        3155                3160                3165
Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr Asn
    3170                3175                3180
Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu Pro
3185                3190                3195                3200
Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp Arg
                3205                3210                3215
Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg Ser
            3220                3225                3230
Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys Gln
        3235                3240                3245
Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys Glu
    3250                3255                3260
Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr Cys
3265                3270                3275                3280
Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln Val
                3285                3290                3295
Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val Ser
            3300                3305                3310
Ser Tyr Leu Xaa Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile Leu
        3315                3320                3325
Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu Pro
    3330                3335                3340
Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu Glu
3345                3350                3355                3360
Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly Leu
                3365                3370                3375
Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala Ser
            3380                3385                3390
Glu Glu Ala Gly Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly Val
        3395                3400                3405
Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu Arg
    3410                3415                3420
Lys Glu Glu Glu Asn Ala Ser Val Thr Asp Ser Ala Glu Leu Gln Ala
3425                3430                3435                3440
Tyr Pro Ala Leu Trp Glu Lys Met Leu Lys Ala Leu Lys Leu Asn Ser
                3445                3450                3455
Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gly Ile Ile Glu Arg
            3460                3465                3470
Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser Ser Val
        3475                3480                3485
Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala Leu Leu
    3490                3495                3500
Asp Lys Asp Gly Ala Val Ala Val Gln His Ser Val Glu Glu Ile Thr
3505                3510                3515                3520
Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser Ser Glu
                3525                3530                3535
Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys Glu Phe
            3540                3545                3550
Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile Gln Asp
        3555                3560                3565
Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu Phe Lys
    3570                3575                3580
Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro Val Asn
3585                3590                3595                3600
Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala Leu Gly
                3605                3610                3615
Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe Ile Gln
            3620                3625                3630
Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly Ser Lys
        3635                3640                3645
Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn Met Leu
    3650                3655                3660
Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu Lys Glu
3665                3670                3675                3680
Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg Asn Glu
                3685                3690                3695
Leu Glu Ile Pro Gly Gly Tyr Asp Gly Arg Gly Lys Pro Leu Pro Glu
            3700                3705                3710
Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val Met Ala
        3715                3720                3725
Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp Glu Arg
    3730                3735                3740
Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln Asp Gln
3745                3750                3755                3760
Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala Gln Asp
                3765                3770                3775
Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser Val Val
            3780                3785                3790
Pro Met Thr Ser Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr Lys Asp
        3795                3800                3805
Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr Met Leu
    3810                3815                3820
Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Glu Arg Lys
3825                3830                3835                3840
Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe Val Arg
                3845                3850                3855
Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His Phe Ala
            3860                3865                3870
Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly Ile Gly
        3875                3880                3885
Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly Gly Val
    3890                3895                3900
Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln Phe Leu
3905                3910                3915                3920
Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe Ile Asn
                3925                3930                3935
Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile Met Val
            3940                3945                3950
His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr Asn Thr
        3955                3960                3965
Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn Phe Glu
    3970                3975                3980
Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile Asn Val
3985                3990                3995                4000
Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala Lys Arg
                4005                4010                4015
Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu Leu Leu
            4020                4025                4030
Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala Val Ala
        4035                4040                4045
Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu Ser Gln
    4050                4055                4060
Leu Ser Glu Glu Thr Gln Val Lys Cys Ile Met Asp Gly Ala Thr Asp
4065                4070                4075                4080
Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp Met
                4085                4090                4095

<210> 573
<211> 4128
<212> PRT
<213> Homo sapiens

<400> 573
Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
 1               5                  10                  15
Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
            20                  25                  30
Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
        35                  40                  45
Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
    50                  55                  60
Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
65                  70                  75                  80
Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                85                  90                  95
Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
            100                 105                 110
Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
        115                 120                 125
Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
    130                 135                 140
Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
145                 150                 155                 160
Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                165                 170                 175
Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
            180                 185                 190
Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
        195                 200                 205
Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
    210                 215                 220
Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
225                 230                 235                 240
Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                245                 250                 255
Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
            260                 265                 270
Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
        275                 280                 285
Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
    290                 295                 300
Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
305                 310                 315                 320
Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                325                 330                 335
Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
            340                 345                 350
Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
        355                 360                 365
Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
    370                 375                 380
Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
385                 390                 395                 400
Asp Thr Gly Asp Asp Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                405                 410                 415
Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
            420                 425                 430
Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
        435                 440                 445
Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
    450                 455                 460
Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
465                 470                 475                 480
Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                485                 490                 495
Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
            500                 505                 510
Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
        515                 520                 525
Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
    530                 535                 540
Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
545                 550                 555                 560
Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                565                 570                 575
Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
            580                 585                 590
Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
        595                 600                 605
Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
    610                 615                 620
Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
625                 630                 635                 640
Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                645                 650                 655
Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
            660                 665                 670
Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
        675                 680                 685
Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
    690                 695                 700
Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
705                 710                 715                 720
Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                725                 730                 735
Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
            740                 745                 750
Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
        755                 760                 765
Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
    770                 775                 780
Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
785                 790                 795                 800
Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                805                 810                 815
Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
            820                 825                 830
His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
        835                 840                 845
Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
    850                 855                 860
Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
865                 870                 875                 880
Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                885                 890                 895
Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
            900                 905                 910
Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
        915                 920                 925
Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
    930                 935                 940
Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
945                 950                 955                 960
Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                965                 970                 975
Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
            980                 985                 990
His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ala
        995                 1000                1005
Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020
Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055
Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070
Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085
Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100
Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135
Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150
Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165
Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180
His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215
Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230
Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245
Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260
Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295
Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310
Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325
Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340
Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375
Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390
Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405
Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420
Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455
Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470
Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485
Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500
Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535
Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550
Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565
Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580
Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615
Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630
Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645
Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660
His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695
Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710
Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725
Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740
Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760
Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775
Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790
Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805
Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820
Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840
Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855
Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870
Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885
Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900
Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920
Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935
Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950
Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965
Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980
Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000
Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015
Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030
Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045
Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060
Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080
Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095
Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110
Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125
Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140
Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160
Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175
Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190
Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205
Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220
His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240
Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255
Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270
Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285
Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300
Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320
Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335
Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350
Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365
Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380
Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400
Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415
Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
            2420                2425                2430
Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
        2435                2440                2445
Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
    2450                2455                2460
Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
2465                2470                2475                2480
His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                2485                2490                2495
Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
            2500                2505                2510
Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
        2515                2520                2525
Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
    2530                2535                2540
Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
2545                2550                2555                2560
Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                2565                2570                2575
Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
            2580                2585                2590
Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
        2595                2600                2605
Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
    2610                2615                2620
Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
2625                2630                2635                2640
Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                2645                2650                2655
Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
            2660                2665                2670
Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
        2675                2680                2685
Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
    2690                2695                2700
Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
2705                2710                2715                2720
Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                2725                2730                2735
Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
            2740                2745                2750
Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
        2755                2760                2765
Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
    2770                2775                2780
Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
2785                2790                2795                2800
Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                2805                2810                2815
Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
            2820                2825                2830
Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
        2835                2840                2845
Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
    2850                2855                2860
His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
2865                2870                2875                2880
Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                2885                2890                2895
Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
            2900                2905                2910
Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
        2915                2920                2925
Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
    2930                2935                2940
Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
2945                2950                2955                2960
Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                2965                2970                2975
Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
            2980                2985                2990
Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
        2995                3000                3005
Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
    3010                3015                3020
Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
3025                3030                3035                3040
Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                3045                3050                3055
Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
            3060                3065                3070
Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
        3075                3080                3085
Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
    3090                3095                3100
Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
3105                3110                3115                3120
Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                3125                3130                3135
Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
            3140                3145                3150
Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
        3155                3160                3165
Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
    3170                3175                3180
Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
3185                3190                3195                3200
Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                3205                3210                3215
Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
            3220                3225                3230
Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
        3235                3240                3245
Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
    3250                3255                3260
Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
3265                3270                3275                3280
Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                3285                3290                3295
Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
            3300                3305                3310
Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
        3315                3320                3325
Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
    3330                3335                3340
Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
3345                3350                3355                3360
Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                3365                3370                3375
Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
            3380                3385                3390
Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
        3395                3400                3405
Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
    3410                3415                3420
Arg Lys Glu Glu Glu Asn Ala Ser Val Ile Asp Ser Ala Glu Leu Gln
3425                3430                3435                3440
Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                3445                3450                3455
Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
            3460                3465                3470
Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
        3475                3480                3485
Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
    3490                3495                3500
Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
3505                3510                3515                3520
Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                3525                3530                3535
Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
            3540                3545                3550
Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
        3555                3560                3565
Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
    3570                3575                3580
Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
3585                3590                3595                3600
Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                3605                3610                3615
Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
            3620                3625                3630
Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
        3635                3640                3645
Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
    3650                3655                3660
Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
3665                3670                3675                3680
Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                3685                3690                3695
Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
            3700                3705                3710
Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
        3715                3720                3725
Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
    3730                3735                3740
Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
3745                3750                3755                3760
Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                3765                3770                3775
Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
            3780                3785                3790
Val Val Pro Met Thr Ser Arg Leu Gly Leu Ile Glu Trp Leu Glu Asn
        3795                3800                3805
Thr Val Thr Leu Lys Asp Leu Leu Leu Asn Thr Met Ser Gln Glu Glu
    3810                3815                3820
Lys Ala Ala Tyr Leu Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr Lys
3825                3830                3835                3840
Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr Met
                3845                3850                3855
Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe Arg
            3860                3865                3870
Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe Val
        3875                3880                3885
Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His Phe
    3890                3895                3900
Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly Ile
3905                3910                3915                3920
Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly Gly
                3925                3930                3935
Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln Phe
            3940                3945                3950
Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe Ile
        3955                3960                3965
Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile Met
    3970                3975                3980
Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr Asn
3985                3990                3995                4000
Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn Phe
                4005                4010                4015
Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile Asn
            4020                4025                4030
Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala Lys
        4035                4040                4045
Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu Leu
    4050                4055                4060
Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala Val
4065                4070                4075                4080
Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu Ser
                4085                4090                4095
Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala Thr
            4100                4105                4110
Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp Met
        4115                4120                4125

<210> 574
<211> 4128
<212> PRT
<213> Homo sapiens

<400> 574
Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
 1               5                  10                  15
Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
            20                  25                  30
Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
        35                  40                  45
Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
    50                  55                  60
Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
65                  70                  75                  80
Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                85                  90                  95
Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
            100                 105                 110
Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
        115                 120                 125
Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
    130                 135                 140
Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
145                 150                 155                 160
Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                165                 170                 175
Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
            180                 185                 190
Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
        195                 200                 205
Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
    210                 215                 220
Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
225                 230                 235                 240
Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                245                 250                 255
Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
            260                 265                 270
Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
        275                 280                 285
Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
    290                 295                 300
Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
305                 310                 315                 320
Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                325                 330                 335
Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
            340                 345                 350
Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
        355                 360                 365
Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
    370                 375                 380
Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
385                 390                 395                 400
Asp Thr Gly Asp Tyr Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                405                 410                 415
Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
            420                 425                 430
Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
        435                 440                 445
Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
    450                 455                 460
Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
465                 470                 475                 480
Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                485                 490                 495
Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
            500                 505                 510
Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
        515                 520                 525
Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
    530                 535                 540
Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
545                 550                 555                 560
Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                565                 570                 575
Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
            580                 585                 590
Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
        595                 600                 605
Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
    610                 615                 620
Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
625                 630                 635                 640
Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                645                 650                 655
Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
            660                 665                 670
Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
        675                 680                 685
Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
    690                 695                 700
Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
705                 710                 715                 720
Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                725                 730                 735
Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
            740                 745                 750
Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
        755                 760                 765
Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
    770                 775                 780
Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
785                 790                 795                 800
Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                805                 810                 815
Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
            820                 825                 830
His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
        835                 840                 845
Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
    850                 855                 860
Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
865                 870                 875                 880
Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                885                 890                 895
Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
            900                 905                 910
Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
        915                 920                 925
Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
    930                 935                 940
Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
945                 950                 955                 960
Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                965                 970                 975
Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
            980                 985                 990
His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ser
        995                 1000                1005
Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020
Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055
Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070
Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085
Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100
Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135
Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150
Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165
Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180
His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215
Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230
Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245
Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260
Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295
Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310
Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325
Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340
Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375
Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390
Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405
Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420
Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455
Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470
Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485
Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500
Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535
Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550
Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565
Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580
Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615
Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630
Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645
Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660
His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695
Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710
Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725
Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740
Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760
Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775
Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790
Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805
Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820
Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840
Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855
Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870
Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885
Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900
Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920
Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935
Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950
Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965
Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980
Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000
Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015
Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030
Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045
Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060
Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080
Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095
Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110
Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125
Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140
Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160
Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175
Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190
Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205
Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220
His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240
Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255
Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270
Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285
Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300
Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320
Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335
Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350
Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365
Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380
Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400
Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415
Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
            2420                2425                2430
Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
        2435                2440                2445
Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
    2450                2455                2460
Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
2465                2470                2475                2480
His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                2485                2490                2495
Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
            2500                2505                2510
Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
        2515                2520                2525
Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
    2530                2535                2540
Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
2545                2550                2555                2560
Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                2565                2570                2575
Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
            2580                2585                2590
Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
        2595                2600                2605
Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
    2610                2615                2620
Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
2625                2630                2635                2640
Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                2645                2650                2655
Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
            2660                2665                2670
Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
        2675                2680                2685
Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
    2690                2695                2700
Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
2705                2710                2715                2720
Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                2725                2730                2735
Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
            2740                2745                2750
Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
        2755                2760                2765
Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
    2770                2775                2780
Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
2785                2790                2795                2800
Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                2805                2810                2815
Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
            2820                2825                2830
Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
        2835                2840                2845
Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
    2850                2855                2860
His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
2865                2870                2875                2880
Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                2885                2890                2895
Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
            2900                2905                2910
Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
        2915                2920                2925
Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
    2930                2935                2940
Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
2945                2950                2955                2960
Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                2965                2970                2975
Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
            2980                2985                2990
Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
        2995                3000                3005
Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
    3010                3015                3020
Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
3025                3030                3035                3040
Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                3045                3050                3055
Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
            3060                3065                3070
Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
        3075                3080                3085
Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
    3090                3095                3100
Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
3105                3110                3115                3120
Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                3125                3130                3135
Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
            3140                3145                3150
Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
        3155                3160                3165
Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
    3170                3175                3180
Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
3185                3190                3195                3200
Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                3205                3210                3215
Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
            3220                3225                3230
Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
        3235                3240                3245
Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
    3250                3255                3260
Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
3265                3270                3275                3280
Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                3285                3290                3295
Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
            3300                3305                3310
Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
        3315                3320                3325
Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
    3330                3335                3340
Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
3345                3350                3355                3360
Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                3365                3370                3375
Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
            3380                3385                3390
Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
        3395                3400                3405
Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
    3410                3415                3420
Arg Lys Glu Glu Glu Asn Ala Ser Val Thr Asp Ser Ala Glu Leu Gln
3425                3430                3435                3440
Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                3445                3450                3455
Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
            3460                3465                3470
Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
        3475                3480                3485
Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
    3490                3495                3500
Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
3505                3510                3515                3520
Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                3525                3530                3535
Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
            3540                3545                3550
Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
        3555                3560                3565
Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
    3570                3575                3580
Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
3585                3590                3595                3600
Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                3605                3610                3615
Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
            3620                3625                3630
Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
        3635                3640                3645
Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
    3650                3655                3660
Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
3665                3670                3675                3680
Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                3685                3690                3695
Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
            3700                3705                3710
Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
        3715                3720                3725
Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
    3730                3735                3740
Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
3745                3750                3755                3760
Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                3765                3770                3775
Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
            3780                3785                3790
Val Val Pro Met Thr Ser Arg Leu Gly Leu Ile Glu Trp Leu Glu Asn
        3795                3800                3805
Thr Val Thr Leu Lys Asp Leu Leu Leu Asn Thr Met Ser Gln Glu Glu
    3810                3815                3820
Lys Ala Ala Tyr Leu Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr Lys
3825                3830                3835                3840
Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr Met
                3845                3850                3855
Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe Arg
            3860                3865                3870
Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe Val
        3875                3880                3885
Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His Phe
    3890                3895                3900
Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly Ile
3905                3910                3915                3920
Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly Gly
                3925                3930                3935
Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln Phe
            3940                3945                3950
Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe Ile
        3955                3960                3965
Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile Met
    3970                3975                3980
Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr Asn
3985                3990                3995                4000
Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn Phe
                4005                4010                4015
Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile Asn
            4020                4025                4030
Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala Lys
        4035                4040                4045
Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu Leu
    4050                4055                4060
Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala Val
4065                4070                4075                4080
Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu Ser
                4085                4090                4095
Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala Thr
            4100                4105                4110
Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp Met
        4115                4120                4125

<210> 575
<211> 864
<212> PRT
<213> Homo sapiens

<400> 575
Met Ala Ala Pro Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr Gly Asn
 1               5                  10                  15
Ser Leu Tyr Glu Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr Thr Gly
            20                  25                  30
Arg Val Gly Ala Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser Gly Leu
        35                  40                  45
Ser Asp Ile Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro Glu Gly
    50                  55                  60
Lys Gly Phe Leu Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg Leu Val
65                  70                  75                  80
Ala Cys Ala Gln Ser Gly His Glu Val Thr Leu Ser Asn Leu Asn Leu
                85                  90                  95
Ser Met Pro Pro Pro Lys Phe His Asp Thr Ser Ser Pro Leu Met Val
            100                 105                 110
Thr Pro Pro Ser Ala Glu Ala His Trp Ala Val Arg Val Glu Glu Lys
        115                 120                 125
Ala Lys Phe Asp Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn Gly Leu
    130                 135                 140
Leu Ser Gly Asp Lys Val Lys Pro Val Leu Met Asn Ser Lys Leu Pro
145                 150                 155                 160
Leu Asp Val Leu Gly Arg Val Trp Asp Leu Ser Asp Ile Asp Lys Asp
                165                 170                 175
Gly His Leu Asp Arg Asp Glu Phe Ala Val Ala Met His Leu Val Tyr
            180                 185                 190
Arg Ala Leu Glu Lys Glu Pro Val Pro Ser Ala Leu Pro Pro Ser Leu
        195                 200                 205
Ile Pro Pro Ser Lys Arg Lys Lys Thr Val Phe Pro Gly Ala Val Pro
    210                 215                 220
Val Leu Pro Ala Ser Pro Pro Pro Lys Asp Ser Leu Arg Ser Thr Pro
225                 230                 235                 240
Ser His Gly Ser Val Ser Ser Leu Asn Ser Thr Gly Ser Leu Ser Pro
                245                 250                 255
Lys His Ser Leu Lys Gln Thr Gln Pro Thr Val Asn Trp Val Val Pro
            260                 265                 270
Val Ala Asp Lys Met Arg Phe Asp Glu Ile Phe Leu Lys Thr Asp Leu
        275                 280                 285
Asp Leu Asp Gly Tyr Val Ser Gly Gln Glu Val Lys Glu Ile Phe Met
    290                 295                 300
His Ser Gly Leu Thr Gln Asn Leu Leu Ala His Ile Trp Ala Leu Ala
305                 310                 315                 320
Asp Thr Arg Gln Thr Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala
                325                 330                 335
Met Tyr Phe Ile Gln Gln Lys Val Ser Lys Gly Ile Asp Pro Pro Gln
            340                 345                 350
Val Leu Ser Pro Asp Met Val Pro Pro Ser Glu Arg Gly Thr Pro Gly
        355                 360                 365
Pro Asp Ser Ser Gly Ser Leu Gly Ser Gly Glu Phe Thr Gly Val Lys
    370                 375                 380
Glu Leu Asp Asp Ile Ser Gln Glu Ile Ala Gln Leu Gln Arg Glu Lys
385                 390                 395                 400
Tyr Ser Leu Glu Gln Asp Ile Arg Glu Lys Glu Glu Ala Ile Arg Gln
                405                 410                 415
Lys Thr Ser Glu Val Gln Glu Leu Gln Asn Asp Leu Asp Arg Glu Thr
            420                 425                 430
Ser Ser Leu Gln Glu Leu Glu Ala Gln Lys Gln Asp Ala Gln Asp Arg
        435                 440                 445
Leu Asp Glu Met Asp Gln Gln Lys Ala Lys Leu Arg Asp Met Leu Ser
    450                 455                 460
Asp Val Arg Gln Lys Cys Gln Asp Glu Thr Gln Met Ile Ser Ser Leu
465                 470                 475                 480
Lys Thr Gln Ile Gln Ser Gln Glu Ser Asp Leu Lys Ser Gln Glu Asp
                485                 490                 495
Asp Leu Asn Arg Ala Lys Ser Glu Leu Asn Arg Leu Gln Gln Glu Glu
            500                 505                 510
Thr Gln Leu Glu Gln Ser Ile Gln Ala Gly Arg Val Gln Leu Glu Thr
        515                 520                 525
Ile Ile Lys Ser Leu Lys Ser Thr Gln Asp Glu Ile Asn Gln Ala Arg
    530                 535                 540
Ser Lys Leu Ser Gln Leu His Glu Ser Arg Gln Glu Ala His Arg Ser
545                 550                 555                 560
Leu Glu Gln Tyr Asp Gln Val Leu Asp Gly Ala His Gly Ala Ser Leu
                565                 570                 575
Thr Asp Leu Ala Asn Leu Ser Glu Gly Val Ser Leu Ala Glu Arg Gly
            580                 585                 590
Ser Phe Gly Ala Met Asp Asp Pro Phe Lys Asn Lys Ala Leu Leu Phe
        595                 600                 605
Ser Asn Asn Thr Gln Glu Leu His Pro Asp Pro Phe Gln Thr Glu Asp
    610                 615                 620
Pro Phe Lys Ser Asp Pro Phe Lys Gly Ala Asp Pro Phe Lys Gly Asp
625                 630                 635                 640
Pro Phe Gln Asn Asp Pro Phe Ala Glu Gln Gln Thr Thr Ser Thr Asp
                645                 650                 655
Pro Phe Gly Gly Asp Pro Phe Lys Glu Ser Asp Pro Phe Arg Gly Ser
            660                 665                 670
Ala Thr Asp Asp Phe Phe Lys Lys Gln Thr Lys Asn Asp Pro Phe Thr
        675                 680                 685
Ser Asp Pro Phe Thr Lys Asn Pro Ser Leu Pro Ser Lys Leu Asp Pro
    690                 695                 700
Phe Glu Ser Ser Asp Pro Phe Ser Ser Ser Ser Val Ser Ser Lys Gly
705                 710                 715                 720
Ser Asp Pro Phe Gly Thr Leu Asp Pro Phe Gly Ser Gly Ser Phe Asn
                725                 730                 735
Ser Ala Glu Gly Phe Ala Asp Phe Ser Gln Met Ser Lys Pro Pro Pro
            740                 745                 750
Ser Gly Pro Phe Thr Ser Ser Leu Gly Gly Ala Gly Phe Ser Asp Asp
        755                 760                 765
Pro Phe Lys Ser Lys Gln Asp Thr Pro Ala Leu Pro Pro Lys Lys Pro
    770                 775                 780
Ala Pro Pro Arg Pro Lys Pro Pro Ser Gly Lys Ser Thr Pro Val Ser
785                 790                 795                 800
Gln Leu Gly Ser Ala Asp Phe Pro Glu Ala Pro Asp Pro Phe Gln Pro
                805                 810                 815
Leu Gly Ala Asp Ser Gly Asp Pro Phe Gln Ser Lys Lys Gly Phe Gly
            820                 825                 830
Asp Pro Phe Ser Gly Lys Asp Pro Phe Val Pro Ser Ser Ala Ala Lys
        835                 840                 845
Pro Ser Lys Ala Ser Ala Ser Gly Phe Ala Asp Phe Thr Ser Val Ser
    850                 855                 860

<210> 576
<211> 864
<212> PRT
<213> Homo sapiens

<400> 576
Met Ala Ala Pro Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr Gly Asn
 1               5                  10                  15
Ser Leu Tyr Glu Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr Thr Gly
            20                  25                  30
Arg Val Gly Ala Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser Gly Leu
        35                  40                  45
Ser Asp Ile Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro Glu Gly
    50                  55                  60
Lys Gly Phe Leu Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg Leu Val
65                  70                  75                  80
Ala Cys Ala Gln Ser Gly His Glu Val Thr Leu Ser Asn Leu Asn Leu
                85                  90                  95
Ser Met Pro Pro Pro Lys Phe His Asp Thr Ser Ser Pro Leu Met Val
            100                 105                 110
Thr Pro Pro Ser Ala Glu Ala His Trp Ala Val Arg Val Glu Glu Lys
        115                 120                 125
Ala Lys Phe Asp Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn Gly Leu
    130                 135                 140
Leu Ser Gly Asp Lys Val Lys Pro Val Leu Met Asn Ser Lys Leu Pro
145                 150                 155                 160
Leu Asp Val Leu Gly Arg Val Trp Asp Leu Ser Asp Ile Asp Lys Asp
                165                 170                 175
Gly His Leu Asp Arg Asp Glu Phe Ala Val Ala Met His Leu Val Tyr
            180                 185                 190
Arg Ala Leu Glu Lys Glu Pro Val Pro Ser Ala Leu Pro Pro Ser Leu
        195                 200                 205
Ile Pro Pro Ser Lys Arg Lys Lys Thr Val Phe Pro Gly Ala Val Pro
    210                 215                 220
Val Leu Pro Ala Ser Pro Pro Pro Lys Asp Ser Leu Arg Ser Thr Pro
225                 230                 235                 240
Ser His Gly Ser Val Ser Ser Leu Asn Ser Thr Gly Ser Leu Ser Pro
                245                 250                 255
Lys His Ser Leu Lys Gln Thr Gln Pro Thr Val Asn Trp Val Val Pro
            260                 265                 270
Val Ala Asp Lys Met Arg Phe Asp Glu Ile Phe Leu Lys Thr Asp Leu
        275                 280                 285
Asp Leu Asp Gly Tyr Val Ser Gly Gln Glu Val Lys Glu Ile Phe Met
    290                 295                 300
His Ser Gly Leu Thr Gln Asn Leu Leu Ala His Ile Trp Ala Leu Ala
305                 310                 315                 320
Asp Thr Arg Gln Thr Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala
                325                 330                 335
Met Tyr Phe Ile Gln Gln Lys Val Ser Lys Gly Ile Asp Pro Pro Gln
            340                 345                 350
Val Leu Ser Pro Asp Met Val Pro Pro Ser Glu Arg Gly Thr Pro Gly
        355                 360                 365
Pro Asp Ser Ser Gly Ser Leu Gly Ser Gly Glu Phe Thr Gly Val Lys
    370                 375                 380
Glu Leu Asp Asp Ile Ser Gln Glu Ile Ala Gln Leu Gln Arg Glu Lys
385                 390                 395                 400
Tyr Ser Leu Glu Gln Asp Ile Arg Glu Lys Glu Glu Ala Ile Arg Gln
                405                 410                 415
Lys Thr Ser Glu Val Gln Glu Leu Gln Asn Asp Leu Asp Arg Glu Thr
            420                 425                 430
Ser Ser Leu Gln Glu Leu Glu Ala Gln Lys Gln Asp Ala Gln Asp Arg
        435                 440                 445
Leu Asp Glu Met Asp Gln Gln Lys Ala Lys Leu Arg Asp Met Leu Ser
    450                 455                 460
Asp Val Arg Gln Lys Cys Gln Asp Glu Thr Gln Met Ile Ser Ser Leu
465                 470                 475                 480
Lys Thr Gln Ile Gln Ser Gln Glu Ser Asp Leu Lys Ser Gln Glu Asp
                485                 490                 495
Asp Leu Asn Arg Ala Lys Ser Glu Leu Asn Arg Leu Gln Gln Glu Glu
            500                 505                 510
Thr Gln Leu Glu Gln Ser Ile Gln Ala Gly Arg Val Gln Leu Glu Thr
        515                 520                 525
Ile Ile Lys Ser Leu Lys Ser Thr Gln Asp Glu Ile Asn Gln Ala Arg
    530                 535                 540
Ser Lys Leu Ser Gln Leu His Glu Ser Arg Gln Glu Ala His Arg Ser
545                 550                 555                 560
Leu Glu Gln Tyr Asp Gln Val Leu Asp Gly Ala His Gly Ala Ser Leu
                565                 570                 575
Thr Asp Leu Ala Asn Leu Ser Glu Gly Val Ser Leu Ala Glu Arg Gly
            580                 585                 590
Ser Phe Gly Ala Met Asp Asp Pro Phe Lys Asn Lys Ala Leu Leu Phe
        595                 600                 605
Ser Asn Asn Thr Gln Glu Leu His Pro Asp Pro Phe Gln Thr Glu Asp
    610                 615                 620
Pro Phe Lys Ser Asp Pro Phe Lys Gly Ala Asp Pro Phe Lys Gly Asp
625                 630                 635                 640
Pro Phe Gln Asn Asp Pro Phe Ala Glu Gln Gln Thr Thr Ser Thr Asp
                645                 650                 655
Pro Phe Gly Gly Asp Pro Phe Lys Glu Ser Asp Pro Phe Arg Gly Ser
            660                 665                 670
Ala Thr Asp Asp Phe Phe Lys Lys Gln Thr Lys Asn Asp Pro Phe Thr
        675                 680                 685
Ser Asp Pro Phe Thr Lys Asn Pro Ser Leu Pro Ser Lys Leu Asp Pro
    690                 695                 700
Phe Glu Ser Ser Asp Pro Phe Ser Ser Ser Ser Val Ser Ser Lys Gly
705                 710                 715                 720
Ser Asp Pro Phe Gly Thr Leu Asp Pro Phe Gly Ser Gly Ser Phe Asn
                725                 730                 735
Ser Ala Glu Gly Phe Ala Asp Phe Ser Gln Met Ser Lys Pro Pro Pro
            740                 745                 750
Ser Gly Pro Phe Thr Ser Ser Leu Gly Gly Ala Gly Phe Ser Asp Asp
        755                 760                 765
Pro Phe Lys Ser Lys Gln Asp Thr Pro Ala Leu Pro Pro Lys Lys Pro
    770                 775                 780
Ala Pro Pro Arg Pro Lys Pro Pro Ser Gly Lys Ser Thr Pro Val Ser
785                 790                 795                 800
Gln Leu Gly Ser Ala Asp Phe Pro Glu Ala Pro Asp Pro Phe Gln Pro
                805                 810                 815
Leu Gly Ala Asp Ser Gly Asp Pro Phe Gln Ser Lys Lys Gly Phe Gly
            820                 825                 830
Asp Pro Phe Ser Gly Lys Asp Pro Phe Val Pro Ser Ser Ala Ala Lys
        835                 840                 845
Pro Ser Lys Ala Ser Ala Ser Gly Phe Ala Asp Phe Thr Ser Val Ser
    850                 855                 860

<210> 577
<211> 754
<212> PRT
<213> Homo sapiens

<400> 577
Met Ala Ala Pro Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr Gly Asn
 1               5                  10                  15
Ser Leu Tyr Glu Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr Thr Gly
            20                  25                  30
Arg Val Gly Ala Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser Gly Leu
        35                  40                  45
Ser Asp Ile Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro Glu Gly
    50                  55                  60
Lys Gly Phe Leu Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg Leu Val
65                  70                  75                  80
Ala Cys Ala Gln Ser Gly His Glu Val Thr Leu Ser Asn Leu Asn Leu
                85                  90                  95
Ser Met Pro Pro Pro Lys Phe His Asp Thr Ser Ser Pro Leu Met Val
            100                 105                 110
Thr Pro Pro Ser Ala Glu Ala His Trp Ala Val Arg Val Glu Glu Lys
        115                 120                 125
Ala Lys Phe Asp Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn Gly Leu
    130                 135                 140
Leu Ser Gly Asp Lys Val Lys Pro Val Leu Met Asn Ser Lys Leu Pro
145                 150                 155                 160
Leu Asp Val Leu Gly Arg Val Trp Asp Leu Ser Asp Ile Asp Lys Asp
                165                 170                 175
Gly His Leu Asp Arg Asp Glu Phe Ala Val Ala Met His Leu Val Tyr
            180                 185                 190
Arg Ala Leu Glu Lys Glu Pro Val Pro Ser Ala Leu Pro Pro Ser Leu
        195                 200                 205
Ile Pro Pro Ser Lys Arg Lys Lys Thr Val Phe Pro Gly Ala Val Pro
    210                 215                 220
Val Leu Pro Ala Ser Pro Pro Pro Lys Asp Ser Leu Arg Ser Thr Pro
225                 230                 235                 240
Ser His Gly Ser Val Ser Ser Leu Asn Ser Thr Gly Ser Leu Ser Pro
                245                 250                 255
Lys His Ser Leu Lys Gln Thr Gln Pro Thr Val Asn Trp Val Val Pro
            260                 265                 270
Val Ala Asp Lys Met Arg Phe Asp Glu Ile Phe Leu Lys Thr Asp Leu
        275                 280                 285
Asp Leu Asp Gly Tyr Val Ser Gly Gln Glu Val Lys Glu Ile Phe Met
    290                 295                 300
His Ser Gly Leu Thr Gln Asn Leu Leu Ala His Ile Trp Ala Leu Ala
305                 310                 315                 320
Asp Thr Arg Gln Thr Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala
                325                 330                 335
Met Tyr Phe Ile Gln Gln Lys Val Ser Lys Gly Ile Asp Pro Pro Gln
            340                 345                 350
Val Leu Ser Pro Asp Met Val Pro Pro Ser Glu Arg Gly Thr Pro Gly
        355                 360                 365
Pro Asp Ser Ser Gly Ser Leu Gly Ser Gly Glu Phe Thr Gly Val Lys
    370                 375                 380
Glu Leu Asp Asp Ile Ser Gln Glu Ile Ala Gln Leu Gln Arg Glu Lys
385                 390                 395                 400
Tyr Ser Leu Glu Gln Asp Ile Arg Glu Lys Glu Glu Ala Ile Arg Gln
                405                 410                 415
Lys Thr Ser Glu Val Gln Glu Leu Gln Asn Asp Leu Asp Arg Glu Thr
            420                 425                 430
Ser Ser Leu Gln Glu Leu Glu Ala Gln Lys Gln Asp Ala Gln Asp Arg
        435                 440                 445
Leu Asp Glu Met Asp Gln Gln Lys Ala Lys Leu Arg Asp Met Leu Ser
    450                 455                 460
Asp Val Arg Gln Lys Cys Gln Asp Glu Thr Gln Met Ile Ser Ser Leu
465                 470                 475                 480
Lys Thr Gln Ile Gln Ser Gln Glu Ser Asp Leu Lys Ser Gln Glu Asp
                485                 490                 495
Asp Leu Asn Arg Ala Lys Ser Glu Leu Asn Arg Leu Gln Gln Glu Glu
            500                 505                 510
Thr Gln Leu Glu Gln Ser Ile Gln Ala Gly Arg Val Gln Leu Glu Thr
        515                 520                 525
Ile Ile Lys Ser Leu Lys Ser Thr Gln Asp Glu Ile Asn Gln Ala Arg
    530                 535                 540
Ser Lys Leu Ser Gln Leu His Glu Ser Arg Gln Glu Ala His Arg Ser
545                 550                 555                 560
Leu Glu Gln Tyr Asp Gln Val Leu Asp Gly Ala His Gly Ala Ser Leu
                565                 570                 575
Thr Asp Leu Ala Asn Leu Ser Glu Gly Val Ser Leu Ala Glu Arg Gly
            580                 585                 590
Ser Phe Gly Ala Met Asp Asp Pro Phe Lys Asn Lys Ala Leu Leu Phe
        595                 600                 605
Ser Asn Asn Thr Gln Glu Leu His Pro Asp Pro Phe Gln Thr Glu Asp
    610                 615                 620
Pro Phe Lys Ser Asp Pro Phe Lys Gly Ala Asp Pro Phe Lys Gly Asp
625                 630                 635                 640
Pro Phe Gln Asn Asp Pro Phe Ala Glu Gln Gln Thr Thr Ser Thr Asp
                645                 650                 655
Pro Phe Gly Gly Asp Pro Phe Lys Glu Ser Asp Pro Phe Arg Gly Ser
            660                 665                 670
Ala Thr Asp Asp Phe Phe Lys Lys Gln Thr Lys Asn Asp Pro Phe Thr
        675                 680                 685
Ser Asp Pro Phe Thr Lys Asn Pro Ser Leu Pro Ser Lys Leu Asp Pro
    690                 695                 700
Phe Glu Ser Ser Asp Pro Phe Ser Ser Ser Ser Val Ser Ser Lys Gly
705                 710                 715                 720
Ser Asp Pro Phe Gly Thr Leu Asp Pro Phe Gly Ser Gly Ser Phe Asn
                725                 730                 735
Ser Ala Glu Gly Phe Ala Asp Phe Ser Gln Met Ser Lys Val Lys Val
            740                 745                 750
His Leu


<210> 578
<211> 864
<212> PRT
<213> Homo sapiens

<400> 578
Met Ala Ala Pro Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr Gly Asn
 1               5                  10                  15
Ser Leu Tyr Glu Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr Thr Gly
            20                  25                  30
Arg Val Gly Ala Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser Gly Leu
        35                  40                  45
Ser Asp Ile Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro Glu Gly
    50                  55                  60
Lys Gly Phe Leu Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg Leu Val
65                  70                  75                  80
Ala Cys Ala Gln Ser Gly His Glu Val Thr Leu Ser Asn Leu Asn Leu
                85                  90                  95
Ser Met Pro Pro Pro Lys Phe His Asp Thr Ser Ser Pro Leu Met Val
            100                 105                 110
Thr Pro Pro Ser Ala Glu Ala His Trp Ala Val Arg Val Glu Glu Lys
        115                 120                 125
Ala Lys Phe Asp Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn Gly Leu
    130                 135                 140
Leu Ser Gly Asp Lys Val Lys Pro Val Leu Met Asn Ser Lys Leu Pro
145                 150                 155                 160
Leu Asp Val Leu Gly Arg Val Trp Asp Leu Ser Asp Ile Asp Lys Asp
                165                 170                 175
Gly His Leu Asp Arg Asp Glu Phe Ala Val Ala Met His Leu Val Tyr
            180                 185                 190
Arg Ala Leu Glu Lys Glu Pro Val Pro Ser Ala Leu Pro Pro Ser Leu
        195                 200                 205
Ile Pro Pro Ser Lys Arg Lys Lys Thr Val Phe Pro Gly Ala Val Pro
    210                 215                 220
Val Leu Pro Ala Ser Pro Pro Pro Lys Asp Ser Leu Arg Ser Thr Pro
225                 230                 235                 240
Ser His Gly Ser Val Ser Ser Leu Asn Ser Thr Gly Ser Leu Ser Pro
                245                 250                 255
Lys His Ser Leu Lys Gln Thr Gln Pro Thr Val Asn Trp Val Val Pro
            260                 265                 270
Val Ala Asp Lys Met Arg Phe Asp Glu Ile Phe Leu Lys Thr Asp Leu
        275                 280                 285
Asp Leu Asp Gly Tyr Val Ser Gly Gln Glu Val Lys Glu Ile Phe Met
    290                 295                 300
His Ser Gly Leu Thr Gln Asn Leu Leu Ala His Ile Trp Ala Leu Ala
305                 310                 315                 320
Asp Thr Arg Gln Thr Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala
                325                 330                 335
Met Tyr Phe Ile Gln Gln Lys Val Ser Lys Gly Ile Asp Pro Pro Gln
            340                 345                 350
Val Leu Ser Pro Asp Met Val Pro Pro Ser Glu Arg Gly Thr Pro Gly
        355                 360                 365
Pro Asp Ser Ser Gly Ser Leu Gly Ser Gly Glu Phe Thr Gly Val Lys
    370                 375                 380
Glu Leu Asp Asp Ile Ser Gln Glu Ile Ala Gln Leu Gln Arg Glu Lys
385                 390                 395                 400
Tyr Ser Leu Glu Gln Asp Ile Arg Glu Lys Glu Glu Ala Ile Arg Gln
                405                 410                 415
Lys Thr Ser Glu Val Gln Glu Leu Gln Asn Asp Leu Asp Arg Glu Thr
            420                 425                 430
Ser Ser Leu Gln Glu Leu Glu Ala Gln Lys Gln Asp Ala Gln Asp Arg
        435                 440                 445
Leu Asp Glu Met Asp Gln Gln Lys Ala Lys Leu Arg Asp Met Leu Ser
    450                 455                 460
Asp Val Arg Gln Lys Cys Gln Asp Glu Thr Gln Met Ile Ser Ser Leu
465                 470                 475                 480
Lys Thr Gln Ile Gln Ser Gln Glu Ser Asp Leu Lys Ser Gln Glu Asp
                485                 490                 495
Asp Leu Asn Arg Ala Lys Ser Glu Leu Asn Arg Leu Gln Gln Glu Glu
            500                 505                 510
Thr Gln Leu Glu Gln Ser Ile Gln Ala Gly Arg Val Gln Leu Glu Thr
        515                 520                 525
Ile Ile Lys Ser Leu Lys Ser Thr Gln Asp Glu Ile Asn Gln Ala Arg
    530                 535                 540
Ser Lys Leu Ser Gln Leu His Glu Ser Arg Gln Glu Ala His Arg Ser
545                 550                 555                 560
Leu Glu Gln Tyr Asp Gln Val Leu Asp Gly Ala His Gly Ala Ser Leu
                565                 570                 575
Thr Asp Leu Ala Asn Leu Ser Glu Gly Val Ser Leu Ala Glu Arg Gly
            580                 585                 590
Ser Phe Gly Ala Met Asp Asp Pro Phe Lys Asn Lys Ala Leu Leu Phe
        595                 600                 605
Ser Asn Asn Thr Gln Glu Leu His Pro Asp Pro Phe Gln Thr Glu Asp
    610                 615                 620
Pro Phe Lys Ser Asp Pro Phe Lys Gly Ala Asp Pro Phe Lys Gly Asp
625                 630                 635                 640
Pro Phe Gln Asn Asp Pro Phe Ala Glu Gln Gln Thr Thr Ser Thr Asp
                645                 650                 655
Pro Phe Gly Gly Asp Pro Phe Lys Glu Ser Asp Pro Phe Arg Gly Ser
            660                 665                 670
Ala Thr Asp Asp Phe Phe Lys Lys Gln Thr Lys Asn Asp Pro Phe Thr
        675                 680                 685
Ser Asp Pro Phe Thr Lys Asn Pro Ser Leu Pro Ser Lys Leu Asp Thr
    690                 695                 700
Phe Glu Ser Ser Asp Pro Phe Ser Ser Ser Ser Val Ser Ser Lys Gly
705                 710                 715                 720
Ser Asp Pro Phe Gly Thr Leu Asp Pro Phe Gly Ser Gly Ser Phe Asn
                725                 730                 735
Ser Ala Glu Gly Phe Ala Asp Phe Ser Gln Met Ser Lys Pro Pro Pro
            740                 745                 750
Ser Gly Pro Phe Thr Ser Ser Leu Gly Gly Ala Gly Phe Ser Asp Asp
        755                 760                 765
Pro Phe Lys Ser Lys Gln Asp Thr Pro Ala Leu Pro Pro Lys Lys Pro
    770                 775                 780
Ala Pro Pro Arg Pro Lys Pro Pro Ser Gly Lys Ser Thr Pro Val Ser
785                 790                 795                 800
Gln Leu Gly Ser Ala Asp Phe Pro Glu Ala Pro Asp Pro Phe Gln Pro
                805                 810                 815
Leu Gly Ala Asp Ser Gly Asp Pro Phe Gln Ser Lys Lys Gly Phe Gly
            820                 825                 830
Asp Pro Phe Ser Gly Lys Asp Pro Phe Val Pro Ser Ser Ala Ala Lys
        835                 840                 845
Pro Ser Lys Ala Ser Ala Ser Gly Phe Ala Asp Phe Thr Ser Val Ser
    850                 855                 860

<210> 579
<211> 208
<212> PRT
<213> Homo sapiens

<400> 579
Ala Arg Gln Leu Arg Asn Ser Trp Val Asp Asp Phe Val Ala Ala Pro
 1               5                  10                  15
Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr Gly Asn Ser Leu Tyr Glu
            20                  25                  30
Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr Thr Gly Arg Val Gly Ala
        35                  40                  45
Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser Gly Leu Ser Asp Ile Ile
    50                  55                  60
Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro Glu Gly Lys Gly Phe Leu
65                  70                  75                  80
Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg Leu Val Ala Cys Ala Gln
                85                  90                  95
Ser Gly His Glu Val Thr Leu Ser Asn Leu Asn Leu Ser Met Pro Pro
            100                 105                 110
Pro Lys Phe His Asp Thr Ser Ser Pro Leu Met Val Thr Pro Pro Ser
        115                 120                 125
Ala Glu Ala His Trp Ala Val Arg Val Glu Glu Lys Ala Lys Phe Asp
    130                 135                 140
Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn Gly Leu Leu Ser Gly Asp
145                 150                 155                 160
Lys Val Lys Pro Val Leu Met Asn Ser Lys Leu Pro Leu Asp Val Leu
                165                 170                 175
Gly Arg Val Trp Asp Leu Ser Asp Ile Asp Lys Asp Gly His Leu Val
            180                 185                 190
Arg Asp Glu Phe Ala Val Ala Met His Leu Val Tyr Arg Ala Leu Glu
        195                 200                 205

<210> 580
<211> 866
<212> PRT
<213> Homo sapiens

<400> 580
Gly Lys Met Ala Ala Pro Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr
 1               5                  10                  15
Gly Asn Ser Leu Tyr Glu Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr
            20                  25                  30
Thr Gly Arg Val Gly Ala Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser
        35                  40                  45
Gly Leu Ser Asp Ile Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro
    50                  55                  60
Glu Gly Lys Gly Phe Leu Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg
65                  70                  75                  80
Leu Val Ala Cys Ala Gln Ser Gly His Glu Val Thr Leu Ser Asn Leu
                85                  90                  95
Asn Leu Ser Met Pro Pro Pro Lys Phe His Asp Thr Ser Ser Pro Leu
            100                 105                 110
Met Val Thr Pro Pro Ser Ala Glu Ala His Trp Ala Val Arg Val Glu
        115                 120                 125
Glu Lys Ala Lys Phe Asp Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn
    130                 135                 140
Gly Leu Leu Ser Gly Asp Lys Val Lys Pro Val Leu Met Asn Ser Lys
145                 150                 155                 160
Leu Pro Leu Asp Val Leu Gly Arg Val Trp Asp Leu Ser Asp Ile Asp
                165                 170                 175
Lys Asp Gly His Leu Asp Arg Asp Glu Phe Ala Val Ala Met His Leu
            180                 185                 190
Val Tyr Arg Ala Leu Glu Lys Glu Pro Val Pro Ser Ala Leu Pro Pro
        195                 200                 205
Ser Leu Ile Pro Pro Ser Lys Arg Lys Lys Thr Val Phe Pro Gly Ala
    210                 215                 220
Val Pro Val Leu Pro Ala Ser Pro Pro Pro Lys Asp Ser Leu Arg Ser
225                 230                 235                 240
Thr Pro Ser His Gly Ser Val Ser Ser Leu Asn Ser Thr Gly Ser Leu
                245                 250                 255
Ser Pro Lys His Ser Leu Lys Gln Thr Gln Pro Thr Val Asn Trp Val
            260                 265                 270
Val Pro Val Ala Asp Lys Met Arg Phe Asp Glu Ile Phe Leu Lys Thr
        275                 280                 285
Asp Leu Asp Leu Asp Gly Tyr Val Ser Gly Gln Glu Val Lys Glu Ile
    290                 295                 300
Phe Met His Ser Gly Leu Thr Gln Asn Leu Leu Ala His Ile Trp Ala
305                 310                 315                 320
Leu Ala Asp Thr Arg Gln Thr Gly Lys Leu Ser Lys Asp Gln Phe Ala
                325                 330                 335
Leu Ala Met Tyr Phe Ile Gln Gln Lys Val Ser Lys Gly Ile Asp Pro
            340                 345                 350
Pro Gln Val Leu Ser Pro Asp Met Val Pro Pro Ser Glu Arg Gly Thr
        355                 360                 365
Pro Gly Pro Asp Ser Ser Gly Ser Leu Gly Ser Gly Glu Phe Thr Gly
    370                 375                 380
Val Lys Glu Leu Asp Asp Ile Ser Gln Glu Ile Ala Gln Leu Gln Arg
385                 390                 395                 400
Glu Lys Tyr Ser Leu Glu Gln Asp Ile Arg Glu Lys Glu Glu Ala Ile
                405                 410                 415
Arg Gln Lys Thr Ser Glu Val Gln Glu Leu Gln Asn Asp Leu Asp Arg
            420                 425                 430
Glu Thr Ser Ser Leu Gln Glu Leu Glu Ala Gln Lys Gln Asp Ala Gln
        435                 440                 445
Asp Arg Leu Asp Glu Met Asp Gln Gln Lys Ala Lys Leu Arg Asp Met
    450                 455                 460
Leu Ser Asp Val Arg Gln Lys Cys Gln Asp Glu Thr Gln Met Ile Ser
465                 470                 475                 480
Ser Leu Lys Thr Gln Ile Gln Ser Gln Glu Ser Asp Leu Lys Ser Gln
                485                 490                 495
Glu Asp Asp Leu Asn Arg Ala Lys Ser Glu Leu Asn Arg Leu Gln Gln
            500                 505                 510
Glu Glu Thr Gln Leu Glu Gln Ser Ile Gln Ala Gly Arg Val Gln Leu
        515                 520                 525
Glu Thr Ile Ile Lys Ser Leu Lys Ser Thr Gln Asp Glu Ile Asn Gln
    530                 535                 540
Ala Arg Ser Lys Leu Ser Gln Leu His Glu Ser Arg Gln Glu Ala His
545                 550                 555                 560
Arg Ser Leu Glu Gln Tyr Asp Gln Val Leu Asp Gly Ala His Gly Ala
                565                 570                 575
Ser Leu Thr Asp Leu Ala Asn Leu Ser Glu Gly Val Ser Leu Ala Glu
            580                 585                 590
Arg Gly Ser Phe Gly Ala Met Asp Asp Pro Phe Lys Asn Lys Ala Leu
        595                 600                 605
Leu Phe Ser Asn Asn Thr Gln Glu Leu His Pro Asp Pro Phe Gln Thr
    610                 615                 620
Glu Asp Pro Phe Lys Ser Asp Pro Phe Lys Gly Ala Asp Pro Phe Lys
625                 630                 635                 640
Gly Asp Pro Phe Gln Asn Asp Pro Phe Ala Glu Gln Gln Thr Thr Ser
                645                 650                 655
Thr Asp Pro Phe Gly Gly Asp Pro Phe Lys Glu Ser Asp Pro Phe Arg
            660                 665                 670
Gly Ser Ala Thr Asp Asp Phe Phe Lys Lys Gln Thr Lys Asn Asp Pro
        675                 680                 685
Phe Thr Ser Asp Pro Phe Thr Lys Asn Pro Ser Leu Pro Ser Lys Leu
    690                 695                 700
Asp Pro Phe Glu Ser Ser Asp Pro Phe Ser Ser Ser Ser Val Ser Ser
705                 710                 715                 720
Lys Gly Ser Asp Pro Phe Gly Thr Leu Asp Pro Phe Gly Ser Gly Ser
                725                 730                 735
Phe Asn Ser Ala Glu Gly Phe Ala Asp Phe Ser Gln Met Ser Lys Pro
            740                 745                 750
Pro Pro Ser Gly Pro Phe Thr Ser Ser Leu Gly Gly Ala Gly Phe Ser
        755                 760                 765
Asp Asp Pro Phe Lys Ser Lys Gln Asp Thr Pro Ala Leu Pro Pro Lys
    770                 775                 780
Lys Pro Ala Pro Pro Arg Pro Lys Pro Pro Ser Gly Lys Ser Thr Pro
785                 790                 795                 800
Val Ser Gln Leu Gly Ser Ala Asp Phe Pro Glu Ala Pro Asp Pro Phe
                805                 810                 815
Gln Pro Leu Gly Ala Asp Ser Gly Asp Pro Phe Gln Ser Lys Lys Gly
            820                 825                 830
Phe Gly Asp Pro Phe Ser Gly Lys Asp Pro Phe Val Pro Ser Ser Ala
        835                 840                 845
Ala Lys Pro Ser Lys Ala Ser Ala Ser Gly Phe Ala Asp Phe Thr Ser
    850                 855                 860
Val Ser
865

<210> 581
<211> 864
<212> PRT
<213> Homo sapiens

<400> 581
Met Ala Ala Pro Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr Gly Asn
 1               5                  10                  15
Ser Leu Tyr Glu Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr Thr Gly
            20                  25                  30
Arg Val Gly Ala Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser Gly Leu
        35                  40                  45
Ser Asp Ile Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro Glu Gly
    50                  55                  60
Lys Gly Phe Leu Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg Leu Val
65                  70                  75                  80
Ala Cys Ala Gln Ser Gly His Glu Val Thr Leu Ser Asn Leu Asn Leu
                85                  90                  95
Ser Met Pro Pro Pro Lys Phe His Asp Thr Ser Ser Pro Leu Met Val
            100                 105                 110
Thr Pro Pro Ser Ala Glu Ala His Trp Ala Val Arg Val Glu Glu Lys
        115                 120                 125
Ala Lys Phe Asp Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn Gly Leu
    130                 135                 140
Leu Ser Gly Asp Lys Val Lys Pro Val Leu Met Asn Ser Lys Leu Pro
145                 150                 155                 160
Leu Asp Val Leu Gly Arg Val Trp Asp Leu Ser Asp Ile Asp Lys Asp
                165                 170                 175
Gly His Leu Asp Arg Asp Glu Phe Ala Val Ala Met His Leu Val Tyr
            180                 185                 190
Arg Ala Leu Glu Lys Glu Pro Val Pro Ser Ala Leu Pro Pro Ser Leu
        195                 200                 205
Ile Pro Pro Ser Lys Arg Lys Lys Thr Val Phe Pro Gly Ala Val Pro
    210                 215                 220
Val Leu Pro Ala Ser Pro Pro Pro Lys Asp Ser Leu Arg Ser Thr Pro
225                 230                 235                 240
Ser His Gly Ser Val Ser Ser Leu Asn Ser Thr Gly Ser Leu Ser Pro
                245                 250                 255
Lys His Ser Leu Lys Gln Thr Gln Pro Thr Val Asn Trp Val Val Pro
            260                 265                 270
Val Ala Asp Lys Met Arg Phe Asp Glu Ile Phe Leu Lys Thr Asp Leu
        275                 280                 285
Asp Leu Asp Gly Tyr Val Ser Gly Gln Glu Val Lys Glu Ile Phe Met
    290                 295                 300
His Ser Gly Leu Thr Gln Asn Leu Leu Ala His Ile Trp Ala Leu Ala
305                 310                 315                 320
Asp Thr Arg Gln Thr Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala
                325                 330                 335
Met Tyr Phe Ile Gln Gln Lys Val Ser Lys Gly Ile Asp Pro Pro Gln
            340                 345                 350
Val Leu Ser Pro Asp Met Val Pro Pro Ser Glu Arg Gly Thr Pro Gly
        355                 360                 365
Pro Asp Ser Ser Gly Ser Leu Gly Ser Gly Glu Phe Thr Gly Val Lys
    370                 375                 380
Glu Leu Asp Asp Ile Ser Gln Glu Ile Ala Gln Leu Gln Arg Glu Lys
385                 390                 395                 400
Tyr Ser Leu Glu Gln Asp Ile Arg Glu Lys Glu Glu Ala Ile Arg Gln
                405                 410                 415
Lys Thr Ser Glu Val Gln Glu Leu Gln Asn Asp Leu Asp Arg Glu Thr
            420                 425                 430
Ser Ser Leu Gln Glu Leu Glu Ala Gln Lys Gln Asp Ala Gln Asp Arg
        435                 440                 445
Leu Asp Glu Met Asp Gln Gln Lys Ala Lys Leu Arg Asp Met Leu Ser
    450                 455                 460
Asp Val Arg Gln Lys Cys Gln Asp Glu Thr Gln Met Ile Ser Ser Leu
465                 470                 475                 480
Lys Thr Gln Ile Gln Ser Gln Glu Ser Asp Leu Lys Ser Gln Glu Asp
                485                 490                 495
Asp Leu Asn Arg Ala Lys Ser Glu Leu Asn Arg Leu Gln Gln Glu Glu
            500                 505                 510
Thr Gln Leu Glu Gln Ser Ile Gln Ala Gly Arg Val Gln Leu Glu Thr
        515                 520                 525
Ile Ile Lys Ser Leu Lys Ser Thr Gln Asp Glu Ile Asn Gln Ala Arg
    530                 535                 540
Ser Lys Leu Ser Gln Leu His Glu Ser Arg Gln Glu Ala His Arg Ser
545                 550                 555                 560
Leu Glu Gln Tyr Asp Gln Val Leu Asp Gly Ala His Gly Ala Ser Leu
                565                 570                 575
Thr Asp Leu Ala Asn Leu Ser Glu Gly Val Ser Leu Ala Glu Arg Gly
            580                 585                 590
Ser Phe Gly Ala Met Asp Asp Pro Phe Lys Asn Lys Ala Leu Leu Phe
        595                 600                 605
Ser Asn Asn Thr Gln Glu Leu His Pro Asp Pro Phe Gln Thr Glu Asp
    610                 615                 620
Pro Phe Lys Ser Asp Pro Phe Lys Gly Ala Asp Pro Phe Lys Gly Asp
625                 630                 635                 640
Pro Phe Gln Asn Asp Pro Phe Ala Glu Gln Gln Thr Thr Ser Thr Asp
                645                 650                 655
Pro Phe Gly Gly Asp Pro Phe Lys Glu Ser Asp Pro Phe Arg Gly Ser
            660                 665                 670
Ala Thr Asp Asp Phe Phe Lys Lys Gln Thr Lys Asn Asp Pro Phe Thr
        675                 680                 685
Ser Asp Pro Phe Thr Lys Asn Pro Ser Leu Pro Ser Lys Leu Asp Pro
    690                 695                 700
Phe Glu Ser Ser Asp Pro Phe Ser Ser Ser Ser Val Ser Ser Lys Gly
705                 710                 715                 720
Ser Asp Pro Phe Gly Thr Leu Asp Pro Phe Gly Ser Gly Ser Phe Asn
                725                 730                 735
Ser Ala Glu Gly Phe Ala Asp Phe Ser Gln Met Ser Lys Pro Pro Pro
            740                 745                 750
Ser Gly Pro Phe Thr Ser Ser Leu Gly Gly Ala Gly Phe Ser Asp Asp
        755                 760                 765
Pro Phe Lys Ser Lys Gln Asp Thr Pro Ala Leu Pro Pro Lys Lys Pro
    770                 775                 780
Ala Pro Pro Arg Pro Lys Pro Pro Ser Gly Lys Ser Thr Pro Val Ser
785                 790                 795                 800
Gln Leu Gly Ser Ala Asp Phe Pro Glu Ala Pro Asp Pro Phe Gln Pro
                805                 810                 815
Leu Gly Ala Asp Ser Gly Asp Pro Phe Gln Ser Lys Lys Gly Phe Gly
            820                 825                 830
Asp Pro Phe Ser Gly Lys Asp Pro Phe Val Pro Ser Ser Ala Ala Lys
        835                 840                 845
Pro Ser Lys Ala Ser Ala Ser Gly Phe Ala Asp Phe Thr Ser Val Ser
    850                 855                 860

<210> 582
<211> 864
<212> PRT
<213> Homo sapiens

<400> 582
Met Ala Ala Pro Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr Gly Asn
 1               5                  10                  15
Ser Leu Tyr Glu Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr Thr Gly
            20                  25                  30
Arg Val Gly Ala Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser Gly Leu
        35                  40                  45
Ser Asp Ile Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro Glu Gly
    50                  55                  60
Lys Gly Phe Leu Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg Leu Val
65                  70                  75                  80
Ala Cys Ala Gln Ser Gly His Glu Val Thr Leu Ser Asn Leu Asn Leu
                85                  90                  95
Ser Met Pro Pro Pro Lys Phe His Asp Thr Ser Ser Pro Leu Met Val
            100                 105                 110
Thr Pro Pro Ser Ala Glu Ala His Trp Ala Val Arg Val Glu Glu Lys
        115                 120                 125
Ala Lys Phe Asp Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn Gly Leu
    130                 135                 140
Leu Ser Gly Asp Lys Val Lys Pro Val Leu Met Asn Ser Lys Leu Pro
145                 150                 155                 160
Leu Asp Val Leu Gly Arg Val Trp Asp Leu Ser Asp Ile Asp Lys Asp
                165                 170                 175
Gly His Leu Asp Arg Asp Glu Phe Ala Val Ala Met His Leu Val Tyr
            180                 185                 190
Arg Ala Leu Glu Lys Glu Pro Val Pro Ser Ala Leu Pro Pro Ser Leu
        195                 200                 205
Ile Pro Pro Ser Lys Arg Lys Lys Thr Val Phe Pro Gly Ala Val Pro
    210                 215                 220
Val Leu Pro Ala Ser Pro Pro Pro Lys Asp Ser Leu Arg Ser Thr Pro
225                 230                 235                 240
Ser His Gly Ser Val Ser Ser Leu Asn Ser Thr Gly Ser Leu Ser Pro
                245                 250                 255
Lys His Ser Leu Lys Gln Thr Gln Pro Thr Val Asn Trp Val Val Pro
            260                 265                 270
Val Ala Asp Lys Met Arg Phe Asp Glu Ile Phe Leu Lys Thr Asp Leu
        275                 280                 285
Asp Leu Asp Gly Tyr Val Ser Gly Gln Glu Val Lys Glu Ile Phe Met
    290                 295                 300
His Ser Gly Leu Thr Gln Asn Leu Leu Ala His Ile Trp Ala Leu Ala
305                 310                 315                 320
Asp Thr Arg Gln Thr Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala
                325                 330                 335
Met Tyr Phe Ile Gln Gln Lys Val Ser Lys Gly Ile Asp Pro Pro Gln
            340                 345                 350
Val Leu Ser Pro Asp Met Val Pro Pro Ser Glu Arg Gly Thr Pro Gly
        355                 360                 365
Pro Asp Ser Ser Gly Ser Leu Gly Ser Gly Glu Phe Thr Gly Val Lys
    370                 375                 380
Glu Leu Asp Asp Ile Ser Gln Glu Ile Ala Gln Leu Gln Arg Glu Lys
385                 390                 395                 400
Tyr Ser Leu Glu Gln Asp Ile Arg Glu Lys Glu Glu Ala Ile Arg Gln
                405                 410                 415
Lys Thr Ser Glu Val Gln Glu Leu Gln Asn Asp Leu Asp Arg Glu Thr
            420                 425                 430
Ser Ser Leu Gln Glu Leu Glu Ala Gln Lys Gln Asp Ala Gln Asp Arg
        435                 440                 445
Leu Asp Glu Met Asp Gln Gln Lys Ala Lys Leu Arg Asp Met Leu Ser
    450                 455                 460
Asp Val Arg Gln Lys Cys Gln Asp Glu Thr Gln Met Ile Ser Ser Leu
465                 470                 475                 480
Lys Thr Gln Ile Gln Ser Gln Glu Ser Asp Leu Lys Ser Gln Glu Asp
                485                 490                 495
Asp Leu Asn Arg Ala Lys Ser Glu Leu Asn Arg Leu Gln Gln Glu Glu
            500                 505                 510
Thr Gln Leu Glu Gln Ser Ile Gln Ala Gly Arg Val Gln Leu Glu Thr
        515                 520                 525
Ile Ile Lys Ser Leu Lys Ser Thr Gln Asp Glu Ile Asn Gln Ala Arg
    530                 535                 540
Ser Lys Leu Ser Gln Leu His Glu Ser Arg Gln Glu Ala His Arg Ser
545                 550                 555                 560
Leu Glu Gln Tyr Asp Gln Val Leu Asp Gly Ala His Gly Ala Ser Leu
                565                 570                 575
Thr Asp Leu Ala Asn Leu Ser Glu Gly Val Ser Leu Ala Glu Arg Gly
            580                 585                 590
Ser Phe Gly Ala Met Asp Asp Pro Phe Lys Asn Lys Ala Leu Leu Phe
        595                 600                 605
Ser Asn Asn Thr Gln Glu Leu His Pro Asp Pro Phe Gln Thr Glu Asp
    610                 615                 620
Pro Phe Lys Ser Asp Pro Phe Lys Gly Ala Asp Pro Phe Lys Gly Asp
625                 630                 635                 640
Pro Phe Gln Asn Asp Pro Phe Ala Glu Gln Gln Thr Thr Ser Thr Asp
                645                 650                 655
Pro Phe Gly Gly Asp Pro Phe Lys Glu Ser Asp Pro Phe Arg Gly Ser
            660                 665                 670
Ala Thr Asp Asp Phe Phe Lys Lys Gln Thr Lys Asn Asp Pro Phe Thr
        675                 680                 685
Ser Asp Pro Phe Thr Lys Asn Pro Ser Leu Pro Ser Lys Leu Asp Pro
    690                 695                 700
Phe Glu Ser Ser Asp Pro Phe Ser Ser Ser Ser Val Ser Ser Lys Gly
705                 710                 715                 720
Ser Asp Pro Phe Gly Thr Leu Asp Pro Phe Gly Ser Gly Ser Phe Asn
                725                 730                 735
Ser Ala Glu Gly Phe Ala Asp Phe Ser Gln Met Ser Lys Pro Pro Pro
            740                 745                 750
Ser Gly Pro Phe Thr Ser Ser Leu Gly Gly Ala Gly Phe Ser Asp Asp
        755                 760                 765
Pro Phe Lys Ser Lys Gln Asp Thr Pro Ala Leu Pro Pro Lys Lys Pro
    770                 775                 780
Ala Pro Pro Arg Pro Lys Pro Pro Ser Gly Lys Ser Thr Pro Val Ser
785                 790                 795                 800
Gln Leu Gly Ser Ala Asp Phe Pro Glu Ala Pro Asp Pro Phe Gln Pro
                805                 810                 815
Leu Gly Ala Asp Ser Gly Asp Pro Phe Gln Ser Lys Lys Gly Phe Gly
            820                 825                 830
Asp Pro Phe Ser Gly Lys Asp Pro Phe Val Pro Ser Ser Ala Ala Lys
        835                 840                 845
Pro Ser Lys Ala Ser Ala Ser Gly Phe Ala Asp Phe Thr Ser Val Ser
    850                 855                 860

<210> 583
<211> 642
<212> PRT
<213> Homo sapiens

<400> 583
Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met
 1               5                  10                  15
Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro
            20                  25                  30
Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro
        35                  40                  45
Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His
    50                  55                  60
Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile
65                  70                  75                  80
Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile
                85                  90                  95
Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val
            100                 105                 110
Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile
        115                 120                 125
Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp
    130                 135                 140
Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr
145                 150                 155                 160
Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His
                165                 170                 175
Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile
            180                 185                 190
Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly
        195                 200                 205
Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu
    210                 215                 220
Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala
225                 230                 235                 240
Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp
                245                 250                 255
Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn
            260                 265                 270
Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys
        275                 280                 285
Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln
    290                 295                 300
Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His
305                 310                 315                 320
Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala
                325                 330                 335
Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu
            340                 345                 350
Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg
        355                 360                 365
Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr
    370                 375                 380
Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys
385                 390                 395                 400
Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His
                405                 410                 415
Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser
            420                 425                 430
Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn
        435                 440                 445
Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu
    450                 455                 460
Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met
465                 470                 475                 480
Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser
                485                 490                 495
Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp
            500                 505                 510
Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys
        515                 520                 525
Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser
    530                 535                 540
Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val
545                 550                 555                 560
Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg
                565                 570                 575
Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His
            580                 585                 590
Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp
        595                 600                 605
Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys
    610                 615                 620
Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser
625                 630                 635                 640
Glu Glu


<210> 584
<211> 642
<212> PRT
<213> Homo sapiens

<400> 584
Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met
 1               5                  10                  15
Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro
            20                  25                  30
Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro
        35                  40                  45
Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His
    50                  55                  60
Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile
65                  70                  75                  80
Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile
                85                  90                  95
Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val
            100                 105                 110
Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile
        115                 120                 125
Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp
    130                 135                 140
Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr
145                 150                 155                 160
Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His
                165                 170                 175
Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile
            180                 185                 190
Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly
        195                 200                 205
Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu
    210                 215                 220
Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala
225                 230                 235                 240
Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp
                245                 250                 255
Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn
            260                 265                 270
Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys
        275                 280                 285
Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln
    290                 295                 300
Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His
305                 310                 315                 320
Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala
                325                 330                 335
Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu
            340                 345                 350
Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg
        355                 360                 365
Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr
    370                 375                 380
Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys
385                 390                 395                 400
Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His
                405                 410                 415
Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser
            420                 425                 430
Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn
        435                 440                 445
Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu
    450                 455                 460
Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met
465                 470                 475                 480
Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser
                485                 490                 495
Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp
            500                 505                 510
Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys
        515                 520                 525
Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser
    530                 535                 540
Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val
545                 550                 555                 560
Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg
                565                 570                 575
Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His
            580                 585                 590
Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp
        595                 600                 605
Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys
    610                 615                 620
Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser
625                 630                 635                 640
Glu Glu


<210> 585
<211> 642
<212> PRT
<213> Homo sapiens

<400> 585
Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met
 1               5                  10                  15
Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro
            20                  25                  30
Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro
        35                  40                  45
Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His
    50                  55                  60
Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile
65                  70                  75                  80
Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile
                85                  90                  95
Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val
            100                 105                 110
Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile
        115                 120                 125
Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp
    130                 135                 140
Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr
145                 150                 155                 160
Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His
                165                 170                 175
Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile
            180                 185                 190
Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly
        195                 200                 205
Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu
    210                 215                 220
Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala
225                 230                 235                 240
Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp
                245                 250                 255
Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn
            260                 265                 270
Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys
        275                 280                 285
Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln
    290                 295                 300
Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His
305                 310                 315                 320
Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala
                325                 330                 335
Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu
            340                 345                 350
Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg
        355                 360                 365
Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr
    370                 375                 380
Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys
385                 390                 395                 400
Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His
                405                 410                 415
Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser
            420                 425                 430
Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn
        435                 440                 445
Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu
    450                 455                 460
Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met
465                 470                 475                 480
Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser
                485                 490                 495
Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp
            500                 505                 510
Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys
        515                 520                 525
Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser
    530                 535                 540
Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val
545                 550                 555                 560
Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg
                565                 570                 575
Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His
            580                 585                 590
Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp
        595                 600                 605
Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys
    610                 615                 620
Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser
625                 630                 635                 640
Glu Glu


<210> 586
<211> 474
<212> PRT
<213> Homo sapiens

<400> 586
Met Tyr Thr Val Gly Ala Pro His Thr Trp Pro His Ile Val Ala Ala
 1               5                  10                  15
Leu Val Trp Leu Ile Asp Cys Ile Lys Ile His Thr Ala Met Lys Glu
            20                  25                  30
Ser Ser Pro Leu Phe Asp Asp Gly Gln Pro Trp Gly Glu Glu Thr Glu
        35                  40                  45
Asp Gly Ile Met His Asn Lys Leu Phe Leu Asp Tyr Thr Ile Lys Cys
    50                  55                  60
Tyr Glu Ser Phe Met Ser Gly Ala Asp Ser Phe Asp Glu Met Asn Ala
65                  70                  75                  80
Glu Leu Gln Ser Lys Leu Lys Asp Leu Phe Asn Val Asp Ala Phe Lys
                85                  90                  95
Leu Glu Ser Leu Glu Ala Lys Asn Arg Ala Leu Asn Glu Gln Ile Ala
            100                 105                 110
Arg Leu Glu Gln Glu Arg Glu Lys Glu Pro Asn Arg Leu Glu Ser Leu
        115                 120                 125
Arg Lys Leu Lys Ala Ser Leu Gln Gly Asp Val Gln Lys Tyr Gln Ala
    130                 135                 140
Tyr Met Ser Asn Leu Glu Ser His Ser Ala Ile Leu Asp Gln Lys Leu
145                 150                 155                 160
Asn Gly Leu Asn Glu Glu Ile Ala Arg Val Glu Leu Glu Cys Glu Thr
                165                 170                 175
Ile Lys Gln Glu Asn Thr Arg Leu Gln Asn Ile Ile Asp Asn Gln Lys
            180                 185                 190
Tyr Ser Val Ala Asp Ile Glu Arg Ile Asn His Glu Arg Asn Glu Leu
        195                 200                 205
Gln Gln Thr Ile Asn Lys Leu Thr Lys Asp Leu Glu Ala Glu Gln Gln
    210                 215                 220
Lys Leu Trp Asn Glu Glu Leu Lys Tyr Ala Arg Gly Lys Glu Ala Ile
225                 230                 235                 240
Glu Thr Gln Leu Ala Glu Tyr His Lys Leu Ala Arg Lys Leu Lys Leu
                245                 250                 255
Ile Pro Lys Gly Ala Glu Asn Ser Lys Gly Tyr Asp Phe Glu Ile Lys
            260                 265                 270
Phe Asn Pro Glu Ala Gly Ala Asn Cys Leu Val Lys Tyr Arg Ala Gln
        275                 280                 285
Val Tyr Val Pro Leu Lys Glu Leu Leu Asn Glu Thr Glu Glu Glu Ile
    290                 295                 300
Asn Lys Ala Leu Asn Lys Lys Met Gly Leu Glu Asp Thr Leu Glu Gln
305                 310                 315                 320
Leu Asn Ala Met Ile Thr Glu Ser Lys Arg Ser Val Gly Thr Leu Lys
                325                 330                 335
Glu Glu Val Gln Lys Leu Asp Asp Leu Tyr Gln Gln Lys Ile Lys Glu
            340                 345                 350
Ala Glu Glu Glu Asp Glu Lys Cys Ala Ser Glu Leu Glu Ser Leu Glu
        355                 360                 365
Lys His Lys His Leu Leu Glu Ser Thr Val Asn Gln Gly Leu Ser Glu
    370                 375                 380
Ala Met Asn Glu Leu Asp Ala Val Gln Arg Glu Tyr Gln Leu Val Val
385                 390                 395                 400
Gln Thr Thr Thr Glu Glu Arg Arg Lys Val Gly Asn Asn Leu Gln Arg
                405                 410                 415
Leu Leu Glu Met Val Ala Thr His Val Gly Ser Val Glu Lys His Leu
            420                 425                 430
Glu Glu Gln Ile Ala Lys Val Asp Arg Glu Tyr Glu Glu Cys Met Ser
        435                 440                 445
Glu Asp Leu Ser Glu Asn Ile Lys Glu Ile Arg Asp Lys Tyr Glu Lys
    450                 455                 460
Lys Ala Thr Leu Ile Lys Ser Ser Glu Glu
465                 470

<210> 587
<211> 642
<212> PRT
<213> Homo sapiens

<400> 587
Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met
 1               5                  10                  15
Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro
            20                  25                  30
Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro
        35                  40                  45
Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His
    50                  55                  60
Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile
65                  70                  75                  80
Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile
                85                  90                  95
Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val
            100                 105                 110
Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile
        115                 120                 125
Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp
    130                 135                 140
Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr
145                 150                 155                 160
Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His
                165                 170                 175
Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile
            180                 185                 190
Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly
        195                 200                 205
Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu
    210                 215                 220
Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala
225                 230                 235                 240
Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp
                245                 250                 255
Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn
            260                 265                 270
Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys
        275                 280                 285
Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln
    290                 295                 300
Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His
305                 310                 315                 320
Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala
                325                 330                 335
Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu
            340                 345                 350
Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg
        355                 360                 365
Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr
    370                 375                 380
Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys
385                 390                 395                 400
Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His
                405                 410                 415
Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser
            420                 425                 430
Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn
        435                 440                 445
Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu
    450                 455                 460
Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met
465                 470                 475                 480
Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser
                485                 490                 495
Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp
            500                 505                 510
Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys
        515                 520                 525
Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser
    530                 535                 540
Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val
545                 550                 555                 560
Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg
                565                 570                 575
Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His
            580                 585                 590
Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp
        595                 600                 605
Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys
    610                 615                 620
Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser
625                 630                 635                 640
Glu Glu


<210> 588
<211> 642
<212> PRT
<213> Homo sapiens

<400> 588
Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met
 1               5                  10                  15
Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro
            20                  25                  30
Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro
        35                  40                  45
Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His
    50                  55                  60
Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile
65                  70                  75                  80
Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile
                85                  90                  95
Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val
            100                 105                 110
Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile
        115                 120                 125
Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp
    130                 135                 140
Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr
145                 150                 155                 160
Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His
                165                 170                 175
Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile
            180                 185                 190
Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly
        195                 200                 205
Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu
    210                 215                 220
Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala
225                 230                 235                 240
Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp
                245                 250                 255
Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn
            260                 265                 270
Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys
        275                 280                 285
Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln
    290                 295                 300
Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His
305                 310                 315                 320
Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala
                325                 330                 335
Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu
            340                 345                 350
Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg
        355                 360                 365
Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr
    370                 375                 380
Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys
385                 390                 395                 400
Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His
                405                 410                 415
Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser
            420                 425                 430
Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn
        435                 440                 445
Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu
    450                 455                 460
Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met
465                 470                 475                 480
Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser
                485                 490                 495
Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp
            500                 505                 510
Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys
        515                 520                 525
Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser
    530                 535                 540
Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val
545                 550                 555                 560
Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg
                565                 570                 575
Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His
            580                 585                 590
Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp
        595                 600                 605
Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys
    610                 615                 620
Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser
625                 630                 635                 640
Glu Glu


<210> 589
<211> 341
<212> PRT
<213> Homo sapiens

<400> 589
Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile
 1               5                  10                  15
His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu
            20                  25                  30
Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr
        35                  40                  45
Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro
    50                  55                  60
Thr Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly Pro
65                  70                  75                  80
Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val
                85                  90                  95
Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser
            100                 105                 110
Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu
        115                 120                 125
Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu
    130                 135                 140
Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu Gln Thr
145                 150                 155                 160
Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro
                165                 170                 175
Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu
            180                 185                 190
Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Val Asn Phe Phe Val Ser
        195                 200                 205
Ser Ile Asn Thr Leu Val Thr Lys Thr Met Glu Asp Thr Leu Met Thr
    210                 215                 220
Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr
225                 230                 235                 240
Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly
                245                 250                 255
Arg Leu Glu Ser Ala Gln Ala Thr Phe Gln Ala His Arg Asp Lys Tyr
            260                 265                 270
Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu
        275                 280                 285
Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn Ala
    290                 295                 300
Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu
305                 310                 315                 320
Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser
                325                 330                 335
Trp Leu Glu Glu Gln
            340

<210> 590
<211> 341
<212> PRT
<213> Homo sapiens

<400> 590
Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile
 1               5                  10                  15
His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu
            20                  25                  30
Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr
        35                  40                  45
Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro
    50                  55                  60
Thr Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly Pro
65                  70                  75                  80
Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val
                85                  90                  95
Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser
            100                 105                 110
Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu
        115                 120                 125
Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu
    130                 135                 140
Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu Gln Thr
145                 150                 155                 160
Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro
                165                 170                 175
Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu
            180                 185                 190
Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Val Asn Phe Phe Val Ser
        195                 200                 205
Ser Ile Asn Thr Leu Val Thr Lys Thr Met Glu Asp Thr Leu Met Thr
    210                 215                 220
Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr
225                 230                 235                 240
Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly
                245                 250                 255
Arg Leu Glu Ser Ala Gln Ala Thr Phe Gln Ala His Arg Asp Lys Tyr
            260                 265                 270
Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu
        275                 280                 285
Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn Ala
    290                 295                 300
Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu
305                 310                 315                 320
Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser
                325                 330                 335
Trp Leu Glu Glu Gln
            340

<210> 591
<211> 303
<212> PRT
<213> Homo sapiens

<400> 591
Met Val Ser Gly Pro Asn Leu Asn Glu Thr Ser Ile Val Ser Gly Gly
 1               5                  10                  15
Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro Thr Gly Ser Gly Arg His
            20                  25                  30
Pro Ser His Ser Thr Thr Pro Ser Gly Pro Gly Asp Glu Val Ala Arg
        35                  40                  45
Gly Ile Ala Gly Glu Lys Phe Asp Ile Val Lys Lys Trp Gly Ile Asn
    50                  55                  60
Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser Glu Arg Phe Gly Arg Gly
65                  70                  75                  80
Ser Arg Thr Val Asp Leu Glu Leu Glu Leu Gln Ile Glu Leu Leu Arg
                85                  90                  95
Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu Gln Leu Gly Arg Ala Leu
            100                 105                 110
Thr Ala His Leu Tyr Ser Leu Leu Gln Thr Gln His Ala Leu Gly Asp
        115                 120                 125
Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro Glu Leu Gln Glu Glu Phe
    130                 135                 140
Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu Cys Lys Asn Gly Glu Thr
145                 150                 155                 160
Leu Leu Gly Ala Val Asn Phe Phe Val Ser Ser Ile Asn Thr Leu Val
                165                 170                 175
Thr Lys Thr Met Glu Asp Thr Leu Met Thr Val Lys Gln Tyr Glu Ala
            180                 185                 190
Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr Asp Leu Glu Glu Leu Ser
        195                 200                 205
Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly Arg Leu Glu Ser Ala Gln
    210                 215                 220
Ala Thr Phe Gln Ala His Arg Asp Lys Tyr Glu Lys Leu Arg Gly Asp
225                 230                 235                 240
Val Ala Ile Lys Leu Lys Phe Leu Glu Glu Asn Lys Ile Lys Val Met
                245                 250                 255
His Lys Gln Leu Leu Leu Phe His Asn Ala Val Ser Ala Tyr Phe Ala
            260                 265                 270
Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu Gln Gln Phe Asn Ile Lys
        275                 280                 285
Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser Trp Leu Glu Glu Gln
    290                 295                 300

<210> 592
<211> 144
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(144)
<223> Xaa = Any Amino Acid

<400> 592
Gly Pro Gly Asp His Val Ala Arg Gly Ile Ser Gly Lys Lys Tyr Asp
 1               5                  10                  15
Ile Gly Gln Lys Trp Gly Met Gly Thr Tyr Lys Cys Thr Lys Glu Leu
            20                  25                  30
Leu Ser Gln Arg Phe Gly Leu Gly Ser Pro Thr Val Asp Leu Glu Leu
        35                  40                  45
Xaa Leu Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser
    50                  55                  60
Val Leu His Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu
65                  70                  75                  80
Gln Thr Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Arg Gln Lys
                85                  90                  95
Ser Pro Gln Leu Gln Glu Glu Phe Gly Cys Tyr Ala Gln Thr Gln Lys
            100                 105                 110
Leu Leu Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Ala Asn Leu Phe
        115                 120                 125
Val Ser Ser Ile Tyr Thr Leu Gly Thr Lys Thr Met Glu Asp Thr Leu
    130                 135                 140

<210> 593
<211> 341
<212> PRT
<213> Homo sapiens

<400> 593
Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile
 1               5                  10                  15
His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu
            20                  25                  30
Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr
        35                  40                  45
Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro
    50                  55                  60
Thr Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly Pro
65                  70                  75                  80
Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val
                85                  90                  95
Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser
            100                 105                 110
Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu
        115                 120                 125
Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu
    130                 135                 140
Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu Gln Thr
145                 150                 155                 160
Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro
                165                 170                 175
Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu
            180                 185                 190
Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Val Asn Phe Phe Val Ser
        195                 200                 205
Ser Ile Asn Thr Leu Val Thr Lys Thr Met Glu Asp Thr Leu Met Thr
    210                 215                 220
Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr
225                 230                 235                 240
Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly
                245                 250                 255
Arg Leu Glu Ser Ala Gln Ala Thr Phe Gln Ala His Arg Asp Lys Tyr
            260                 265                 270
Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu
        275                 280                 285
Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn Ala
    290                 295                 300
Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu
305                 310                 315                 320
Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser
                325                 330                 335
Trp Leu Glu Glu Gln
            340

<210> 594
<211> 341
<212> PRT
<213> Homo sapiens

<400> 594
Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile
 1               5                  10                  15
His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu
            20                  25                  30
Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr
        35                  40                  45
Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro
    50                  55                  60
Thr Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly Pro
65                  70                  75                  80
Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val
                85                  90                  95
Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser
            100                 105                 110
Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu
        115                 120                 125
Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu
    130                 135                 140
Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu Gln Thr
145                 150                 155                 160
Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro
                165                 170                 175
Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu
            180                 185                 190
Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Val Asn Phe Phe Val Ser
        195                 200                 205
Ser Ile Asn Thr Leu Val Thr Lys Thr Met Glu Asp Thr Leu Met Thr
    210                 215                 220
Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr
225                 230                 235                 240
Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly
                245                 250                 255
Arg Leu Glu Ser Ala Gln Ala Thr Phe Gln Ala His Arg Asp Lys Tyr
            260                 265                 270
Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu
        275                 280                 285
Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn Ala
    290                 295                 300
Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu
305                 310                 315                 320
Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser
                325                 330                 335
Trp Leu Glu Glu Gln
            340

<210> 595
<211> 434
<212> PRT
<213> Homo sapiens

<400> 595
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 596
<211> 434
<212> PRT
<213> Homo sapiens

<400> 596
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 597
<211> 434
<212> PRT
<213> Homo sapiens

<400> 597
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 598
<211> 434
<212> PRT
<213> Homo sapiens

<400> 598
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 599
<211> 434
<212> PRT
<213> Homo sapiens

<400> 599
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 600
<211> 434
<212> PRT
<213> Homo sapiens

<400> 600
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 601
<211> 434
<212> PRT
<213> Homo sapiens

<400> 601
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 602
<211> 434
<212> PRT
<213> Homo sapiens

<400> 602
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 603
<211> 434
<212> PRT
<213> Homo sapiens

<400> 603
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Ser Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 604
<211> 429
<212> PRT
<213> Homo sapiens

<400> 604
Met Ala Ser Leu Lys Glu Leu Ala Pro Thr Gly Arg Ile Met Asn Ser
 1               5                  10                  15
Cys Met Ala Ser Leu Phe Pro Ala Trp Glu Pro Pro Leu Ile Thr Leu
            20                  25                  30
Lys Ala Gly Thr Gly Ser Met Arg Ser Gly Phe Pro Ala Lys Ser Ala
        35                  40                  45
Met Trp Arg Tyr Arg Gly Thr Pro Phe Ser Lys Ala Val Glu His Ile
    50                  55                  60
Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys Lys Leu Asn Val Thr
65                  70                  75                  80
Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu Met Asp Gly Thr Glu
                85                  90                  95
Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu Gly Val Ser Leu Ala
            100                 105                 110
Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val Pro Leu Tyr Arg His
        115                 120                 125
Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile Leu Pro Val Pro Ala
    130                 135                 140
Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly Asn Lys Leu Ala Met
145                 150                 155                 160
Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn Phe Arg Glu Ala
                165                 170                 175
Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn Val Ile Lys
            180                 185                 190
Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu Gly Gly Phe
        195                 200                 205
Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu Leu Leu Lys Thr
    210                 215                 220
Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val Ile Gly Met Asp
225                 230                 235                 240
Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr Asp Leu Asp Phe
                245                 250                 255
Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp Gln Leu Ala
            260                 265                 270
Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val Val Ser Ile Glu
        275                 280                 285
Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln Lys Phe Thr Ala
    290                 295                 300
Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val Thr Asn Pro
305                 310                 315                 320
Lys Arg Ile Ala Gln Ala Val Asn Glu Lys Ser Cys Asn Cys Leu Leu
                325                 330                 335
Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser Leu Gln Ala Cys
            340                 345                 350
Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val Ser His Arg Ser
        355                 360                 365
Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val Gly Leu Cys
    370                 375                 380
Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala
385                 390                 395                 400
Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly Ser Lys Ala
                405                 410                 415
Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala Lys
            420                 425

<210> 605
<211> 113
<212> PRT
<213> Homo sapiens

<400> 605
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Thr Pro Phe Trp
            100                 105                 110
Gly


<210> 606
<211> 120
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(120)
<223> Xaa = Any Amino Acid

<400> 606
Tyr Glu Ala Leu Glu Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly
 1               5                  10                  15
Lys Gly Val Ser Lys Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro
            20                  25                  30
Ala Leu Val Ser Lys Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp
        35                  40                  45
Lys Leu Met Ile Glu Met Asp Gly Thr Glu Asn Lys Ser Xaa Phe Gly
    50                  55                  60
Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala
65                  70                  75                  80
Val Glu Lys Gly Val Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly
                85                  90                  95
Asn Ser Glu Val Ile Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly
            100                 105                 110
Gly Ser His Ala Gly Asn Lys Leu
        115                 120

<210> 607
<211> 162
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(162)
<223> Xaa = Any Amino Acid

<400> 607
Gln Met His Leu Trp Ala Gly Gly Asp Leu Gly Leu Cys Trp Asn Trp
 1               5                  10                  15
Ile Ser Glu Leu Leu Leu His Leu Phe Ser Ser His Pro Gly Leu Phe
            20                  25                  30
Arg Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu
        35                  40                  45
Glu Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser
    50                  55                  60
Lys Ala Val Glu His Xaa Asn Lys Thr Ile Ala Pro Ala Leu Val Ser
65                  70                  75                  80
Lys Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile
                85                  90                  95
Glu Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile
            100                 105                 110
Leu Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly
        115                 120                 125
Val Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val
    130                 135                 140
Ile Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Xaa Ser His Ala
145                 150                 155                 160
Gly Asn


<210> 608
<211> 433
<212> PRT
<213> Homo sapiens

<400> 608
Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn
 1               5                  10                  15
Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg Ala
            20                  25                  30
Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu Leu
        35                  40                  45
Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys Ala
    50                  55                  60
Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys Lys
65                  70                  75                  80
Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu Met
                85                  90                  95
Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu Gly
            100                 105                 110
Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val Pro
        115                 120                 125
Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile Leu
    130                 135                 140
Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly Asn
145                 150                 155                 160
Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn
                165                 170                 175
Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys
            180                 185                 190
Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp
        195                 200                 205
Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu
    210                 215                 220
Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val
225                 230                 235                 240
Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr
                245                 250                 255
Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro
            260                 265                 270
Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val
        275                 280                 285
Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln
    290                 295                 300
Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr
305                 310                 315                 320
Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys
                325                 330                 335
Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser
            340                 345                 350
Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val
        355                 360                 365
Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val
    370                 375                 380
Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser
385                 390                 395                 400
Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu
                405                 410                 415
Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala
            420                 425                 430
Lys


<210> 609
<211> 434
<212> PRT
<213> Homo sapiens

<400> 609
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430
Ala Lys


<210> 610
<211> 433
<212> PRT
<213> Homo sapiens

<400> 610
Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn
 1               5                  10                  15
Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg Ala
            20                  25                  30
Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu Leu
        35                  40                  45
Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys Ala
    50                  55                  60
Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys Lys
65                  70                  75                  80
Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu Met
                85                  90                  95
Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu Gly
            100                 105                 110
Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val Pro
        115                 120                 125
Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile Leu
    130                 135                 140
Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly Asn
145                 150                 155                 160
Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn
                165                 170                 175
Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys
            180                 185                 190
Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp
        195                 200                 205
Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu
    210                 215                 220
Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val
225                 230                 235                 240
Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr
                245                 250                 255
Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro
            260                 265                 270
Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val
        275                 280                 285
Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln
    290                 295                 300
Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr
305                 310                 315                 320
Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys
                325                 330                 335
Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser
            340                 345                 350
Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val
        355                 360                 365
Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val
    370                 375                 380
Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser
385                 390                 395                 400
Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu
                405                 410                 415
Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala
            420                 425                 430
Lys


<210> 611
<211> 798
<212> PRT
<213> Homo sapiens

<400> 611
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg
 1               5                  10                  15
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr
            20                  25                  30
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala
        35                  40                  45
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys
    50                  55                  60
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys
65                  70                  75                  80
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu
                85                  90                  95
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser
            100                 105                 110
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val
        115                 120                 125
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe
    130                 135                 140
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu
145                 150                 155                 160
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His
                165                 170                 175
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly
            180                 185                 190
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val
        195                 200                 205
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln
    210                 215                 220
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln
225                 230                 235                 240
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp
                245                 250                 255
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln
            260                 265                 270
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser
        275                 280                 285
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe
    290                 295                 300
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser
305                 310                 315                 320
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala
                325                 330                 335
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala
            340                 345                 350
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val
        355                 360                 365
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp
    370                 375                 380
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu
385                 390                 395                 400
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu
                405                 410                 415
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg
            420                 425                 430
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys
        435                 440                 445
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu
    450                 455                 460
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp
465                 470                 475                 480
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln
                485                 490                 495
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu
            500                 505                 510
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg
        515                 520                 525
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln
    530                 535                 540
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu
545                 550                 555                 560
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly
                565                 570                 575
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr
            580                 585                 590
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro
        595                 600                 605
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys
    610                 615                 620
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly
625                 630                 635                 640
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala
                645                 650                 655
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His
            660                 665                 670
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys
        675                 680                 685
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp
    690                 695                 700
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly
705                 710                 715                 720
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val
                725                 730                 735
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile
            740                 745                 750
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu
        755                 760                 765
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr
    770                 775                 780
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu
785                 790                 795

<210> 612
<211> 798
<212> PRT
<213> Homo sapiens

<400> 612
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg
 1               5                  10                  15
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr
            20                  25                  30
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala
        35                  40                  45
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys
    50                  55                  60
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys
65                  70                  75                  80
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu
                85                  90                  95
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser
            100                 105                 110
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val
        115                 120                 125
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe
    130                 135                 140
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu
145                 150                 155                 160
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His
                165                 170                 175
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly
            180                 185                 190
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val
        195                 200                 205
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln
    210                 215                 220
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln
225                 230                 235                 240
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp
                245                 250                 255
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln
            260                 265                 270
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser
        275                 280                 285
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe
    290                 295                 300
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser
305                 310                 315                 320
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala
                325                 330                 335
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala
            340                 345                 350
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val
        355                 360                 365
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp
    370                 375                 380
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu
385                 390                 395                 400
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu
                405                 410                 415
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg
            420                 425                 430
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys
        435                 440                 445
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu
    450                 455                 460
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp
465                 470                 475                 480
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln
                485                 490                 495
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu
            500                 505                 510
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg
        515                 520                 525
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln
    530                 535                 540
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu
545                 550                 555                 560
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly
                565                 570                 575
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr
            580                 585                 590
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro
        595                 600                 605
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys
    610                 615                 620
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly
625                 630                 635                 640
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala
                645                 650                 655
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His
            660                 665                 670
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys
        675                 680                 685
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp
    690                 695                 700
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly
705                 710                 715                 720
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val
                725                 730                 735
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile
            740                 745                 750
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu
        755                 760                 765
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr
    770                 775                 780
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu
785                 790                 795

<210> 613
<211> 798
<212> PRT
<213> Homo sapiens

<400> 613
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg
 1               5                  10                  15
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr
            20                  25                  30
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala
        35                  40                  45
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys
    50                  55                  60
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys
65                  70                  75                  80
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu
                85                  90                  95
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser
            100                 105                 110
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val
        115                 120                 125
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe
    130                 135                 140
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu
145                 150                 155                 160
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His
                165                 170                 175
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly
            180                 185                 190
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val
        195                 200                 205
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln
    210                 215                 220
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln
225                 230                 235                 240
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp
                245                 250                 255
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln
            260                 265                 270
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser
        275                 280                 285
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe
    290                 295                 300
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser
305                 310                 315                 320
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala
                325                 330                 335
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala
            340                 345                 350
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val
        355                 360                 365
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp
    370                 375                 380
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu
385                 390                 395                 400
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu
                405                 410                 415
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg
            420                 425                 430
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys
        435                 440                 445
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu
    450                 455                 460
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp
465                 470                 475                 480
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln
                485                 490                 495
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu
            500                 505                 510
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg
        515                 520                 525
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln
    530                 535                 540
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu
545                 550                 555                 560
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly
                565                 570                 575
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr
            580                 585                 590
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro
        595                 600                 605
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys
    610                 615                 620
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly
625                 630                 635                 640
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala
                645                 650                 655
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His
            660                 665                 670
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys
        675                 680                 685
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp
    690                 695                 700
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly
705                 710                 715                 720
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val
                725                 730                 735
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile
            740                 745                 750
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu
        755                 760                 765
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr
    770                 775                 780
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu
785                 790                 795

<210> 614
<211> 798
<212> PRT
<213> Homo sapiens

<400> 614
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg
 1               5                  10                  15
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr
            20                  25                  30
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala
        35                  40                  45
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys
    50                  55                  60
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys
65                  70                  75                  80
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu
                85                  90                  95
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser
            100                 105                 110
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val
        115                 120                 125
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe
    130                 135                 140
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu
145                 150                 155                 160
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His
                165                 170                 175
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly
            180                 185                 190
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val
        195                 200                 205
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln
    210                 215                 220
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln
225                 230                 235                 240
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp
                245                 250                 255
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln
            260                 265                 270
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser
        275                 280                 285
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe
    290                 295                 300
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser
305                 310                 315                 320
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala
                325                 330                 335
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala
            340                 345                 350
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val
        355                 360                 365
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp
    370                 375                 380
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu
385                 390                 395                 400
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu
                405                 410                 415
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg
            420                 425                 430
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys
        435                 440                 445
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu
    450                 455                 460
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp
465                 470                 475                 480
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln
                485                 490                 495
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu
            500                 505                 510
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg
        515                 520                 525
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln
    530                 535                 540
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu
545                 550                 555                 560
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly
                565                 570                 575
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr
            580                 585                 590
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro
        595                 600                 605
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys
    610                 615                 620
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly
625                 630                 635                 640
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala
                645                 650                 655
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His
            660                 665                 670
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys
        675                 680                 685
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp
    690                 695                 700
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly
705                 710                 715                 720
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val
                725                 730                 735
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile
            740                 745                 750
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu
        755                 760                 765
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr
    770                 775                 780
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu
785                 790                 795

<210> 615
<211> 798
<212> PRT
<213> Homo sapiens

<400> 615
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg
 1               5                  10                  15
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr
            20                  25                  30
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala
        35                  40                  45
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys
    50                  55                  60
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys
65                  70                  75                  80
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu
                85                  90                  95
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser
            100                 105                 110
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val
        115                 120                 125
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe
    130                 135                 140
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu
145                 150                 155                 160
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His
                165                 170                 175
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly
            180                 185                 190
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val
        195                 200                 205
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln
    210                 215                 220
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln
225                 230                 235                 240
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp
                245                 250                 255
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln
            260                 265                 270
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser
        275                 280                 285
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe
    290                 295                 300
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser
305                 310                 315                 320
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala
                325                 330                 335
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala
            340                 345                 350
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val
        355                 360                 365
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp
    370                 375                 380
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu
385                 390                 395                 400
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu
                405                 410                 415
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg
            420                 425                 430
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys
        435                 440                 445
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu
    450                 455                 460
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp
465                 470                 475                 480
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln
                485                 490                 495
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu
            500                 505                 510
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg
        515                 520                 525
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln
    530                 535                 540
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu
545                 550                 555                 560
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly
                565                 570                 575
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr
            580                 585                 590
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro
        595                 600                 605
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys
    610                 615                 620
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly
625                 630                 635                 640
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala
                645                 650                 655
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His
            660                 665                 670
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys
        675                 680                 685
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp
    690                 695                 700
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly
705                 710                 715                 720
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val
                725                 730                 735
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile
            740                 745                 750
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu
        755                 760                 765
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr
    770                 775                 780
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu
785                 790                 795

<210> 616
<211> 798
<212> PRT
<213> Homo sapiens

<400> 616
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg
 1               5                  10                  15
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr
            20                  25                  30
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala
        35                  40                  45
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys
    50                  55                  60
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys
65                  70                  75                  80
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu
                85                  90                  95
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser
            100                 105                 110
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val
        115                 120                 125
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe
    130                 135                 140
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu
145                 150                 155                 160
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His
                165                 170                 175
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly
            180                 185                 190
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val
        195                 200                 205
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln
    210                 215                 220
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln
225                 230                 235                 240
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp
                245                 250                 255
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln
            260                 265                 270
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser
        275                 280                 285
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe
    290                 295                 300
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser
305                 310                 315                 320
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala
                325                 330                 335
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala
            340                 345                 350
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val
        355                 360                 365
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp
    370                 375                 380
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu
385                 390                 395                 400
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu
                405                 410                 415
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg
            420                 425                 430
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys
        435                 440                 445
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu
    450                 455                 460
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp
465                 470                 475                 480
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln
                485                 490                 495
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu
            500                 505                 510
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg
        515                 520                 525
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln
    530                 535                 540
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu
545                 550                 555                 560
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly
                565                 570                 575
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr
            580                 585                 590
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro
        595                 600                 605
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys
    610                 615                 620
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly
625                 630                 635                 640
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala
                645                 650                 655
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His
            660                 665                 670
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys
        675                 680                 685
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp
    690                 695                 700
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly
705                 710                 715                 720
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val
                725                 730                 735
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile
            740                 745                 750
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu
        755                 760                 765
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr
    770                 775                 780
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu
785                 790                 795

<210> 617
<211> 798
<212> PRT
<213> Homo sapiens

<400> 617
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg
 1               5                  10                  15
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr
            20                  25                  30
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala
        35                  40                  45
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys
    50                  55                  60
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys
65                  70                  75                  80
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu
                85                  90                  95
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser
            100                 105                 110
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val
        115                 120                 125
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe
    130                 135                 140
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu
145                 150                 155                 160
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His
                165                 170                 175
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly
            180                 185                 190
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val
        195                 200                 205
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln
    210                 215                 220
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln
225                 230                 235                 240
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp
                245                 250                 255
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln
            260                 265                 270
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser
        275                 280                 285
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe
    290                 295                 300
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser
305                 310                 315                 320
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala
                325                 330                 335
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala
            340                 345                 350
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val
        355                 360                 365
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp
    370                 375                 380
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu
385                 390                 395                 400
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu
                405                 410                 415
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg
            420                 425                 430
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys
        435                 440                 445
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu
    450                 455                 460
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp
465                 470                 475                 480
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln
                485                 490                 495
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu
            500                 505                 510
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg
        515                 520                 525
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln
    530                 535                 540
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu
545                 550                 555                 560
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly
                565                 570                 575
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr
            580                 585                 590
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro
        595                 600                 605
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys
    610                 615                 620
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly
625                 630                 635                 640
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala
                645                 650                 655
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His
            660                 665                 670
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys
        675                 680                 685
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp
    690                 695                 700
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly
705                 710                 715                 720
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val
                725                 730                 735
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile
            740                 745                 750
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu
        755                 760                 765
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr
    770                 775                 780
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu
785                 790                 795

<210> 618
<211> 798
<212> PRT
<213> Homo sapiens

<400> 618
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg
 1               5                  10                  15
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr
            20                  25                  30
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala
        35                  40                  45
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys
    50                  55                  60
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys
65                  70                  75                  80
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu
                85                  90                  95
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser
            100                 105                 110
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val
        115                 120                 125
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe
    130                 135                 140
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu
145                 150                 155                 160
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His
                165                 170                 175
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly
            180                 185                 190
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val
        195                 200                 205
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln
    210                 215                 220
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln
225                 230                 235                 240
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp
                245                 250                 255
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln
            260                 265                 270
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser
        275                 280                 285
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe
    290                 295                 300
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser
305                 310                 315                 320
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala
                325                 330                 335
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala
            340                 345                 350
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val
        355                 360                 365
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp
    370                 375                 380
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu
385                 390                 395                 400
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu
                405                 410                 415
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg
            420                 425                 430
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys
        435                 440                 445
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu
    450                 455                 460
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp
465                 470                 475                 480
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln
                485                 490                 495
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu
            500                 505                 510
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg
        515                 520                 525
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln
    530                 535                 540
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu
545                 550                 555                 560
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly
                565                 570                 575
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr
            580                 585                 590
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro
        595                 600                 605
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys
    610                 615                 620
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly
625                 630                 635                 640
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala
                645                 650                 655
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His
            660                 665                 670
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys
        675                 680                 685
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp
    690                 695                 700
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly
705                 710                 715                 720
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val
                725                 730                 735
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile
            740                 745                 750
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu
        755                 760                 765
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr
    770                 775                 780
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu
785                 790                 795

<210> 619
<211> 302
<212> PRT
<213> Homo sapiens

<400> 619
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
 1               5                  10                  15
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
            20                  25                  30
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
        35                  40                  45
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
    50                  55                  60
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
65                  70                  75                  80
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
                85                  90                  95
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
            100                 105                 110
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
        115                 120                 125
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val
    130                 135                 140
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
145                 150                 155                 160
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
                165                 170                 175
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
            180                 185                 190
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
        195                 200                 205
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
    210                 215                 220
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
225                 230                 235                 240
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
                245                 250                 255
Lys Phe Leu Thr Glu Trp Gly Leu Gly Glu Leu Pro Phe Pro Val Arg
            260                 265                 270
Cys Pro Leu Tyr Leu Glu Ile Phe Leu Gln Asn Ser Pro Arg Thr Cys
        275                 280                 285
Asp Phe Ser Met Tyr Ser Gly Cys Pro Glu Asp Arg Ala Val
    290                 295                 300

<210> 620
<211> 539
<212> PRT
<213> Homo sapiens

<400> 620
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45
Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu
    50                  55                  60
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val
        275                 280                 285
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535

<210> 621
<211> 155
<212> PRT
<213> Homo sapiens

<400> 621
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
 1               5                  10                  15
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
            20                  25                  30
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
        35                  40                  45
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
    50                  55                  60
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
65                  70                  75                  80
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
                85                  90                  95
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
            100                 105                 110
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
        115                 120                 125
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
    130                 135                 140
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser
145                 150                 155

<210> 622
<211> 539
<212> PRT
<213> Homo sapiens

<400> 622
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45
Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu
    50                  55                  60
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Ser Val
        275                 280                 285
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535

<210> 623
<211> 539
<212> PRT
<213> Homo sapiens

<400> 623
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45
Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu
    50                  55                  60
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val
        275                 280                 285
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535

<210> 624
<211> 539
<212> PRT
<213> Homo sapiens

<400> 624
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45
Gly Gly Gly Gln Arg Arg Ile Asp Ala His Asp Lys Arg Gly Lys Leu
    50                  55                  60
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val
        275                 280                 285
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535

<210> 625
<211> 484
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(484)
<223> Xaa = Any Amino Acid

<400> 625
Trp Leu Leu Arg Ser Pro Gly Lys Leu Thr Ala Arg Glu Arg Ile Ser
 1               5                  10                  15
Leu Leu Leu Asp Pro Gly Ser Phe Xaa Glu Ser Asp Met Phe Val Glu
            20                  25                  30
His Arg Cys Ala Asp Phe Gly Met Ala Ala Asp Lys Asn Lys Phe Pro
        35                  40                  45
Gly Asp Ser Val Val Thr Gly Arg Gly Arg Ile Asn Gly Arg Leu Val
    50                  55                  60
Tyr Val Phe Ser Gln Asp Phe Thr Val Phe Gly Gly Ser Leu Ser Gly
65                  70                  75                  80
Ala His Ala Gln Lys Ile Cys Lys Ile Met Asp Gln Ala Ile Thr Val
                85                  90                  95
Gly Ala Pro Val Ile Gly Leu Asn Asp Ser Gly Gly Ala Arg Ile Gln
            100                 105                 110
Glu Gly Val Glu Ser Leu Ala Gly Tyr Ala Asp Ile Phe Leu Arg Asn
        115                 120                 125
Val Thr Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Pro
    130                 135                 140
Cys Ala Gly Gly Ala Val Tyr Ser Pro Ala Leu Thr Asp Phe Thr Phe
145                 150                 155                 160
Met Val Lys Asp Thr Ser Tyr Leu Phe Ile Thr Gly Pro Asp Val Val
                165                 170                 175
Lys Ser Val Thr Asn Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala
            180                 185                 190
Lys Thr His Thr Thr Met Ser Gly Val Ala His Arg Ala Phe Glu Asn
        195                 200                 205
Asp Val Asp Ala Leu Cys Asn Leu Arg Asp Phe Phe Asn Tyr Leu Pro
    210                 215                 220
Leu Ser Ser Gln Asp Pro Ala Pro Val Arg Glu Cys His Asp Pro Ser
225                 230                 235                 240
Asp Arg Leu Val Pro Glu Leu Asp Thr Ile Val Pro Leu Glu Ser Thr
                245                 250                 255
Lys Ala Tyr Asn Met Val Asp Ile Ile His Ser Val Val Asp Glu Arg
            260                 265                 270
Glu Phe Phe Glu Ile Met Pro Asn Tyr Ala Lys Asn Ile Ile Val Gly
        275                 280                 285
Phe Ala Arg Met Asn Gly Arg Thr Val Gly Ile Val Gly Asn Gln Pro
    290                 295                 300
Lys Val Ala Ser Gly Cys Leu Asp Ile Asn Ser Ser Val Lys Gly Ala
305                 310                 315                 320
Arg Phe Val Arg Phe Cys Asp Ala Phe Asn Ile Pro Leu Ile Thr Phe
                325                 330                 335
Val Asp Val Pro Gly Phe Leu Pro Gly Thr Ala Gln Glu Tyr Gly Gly
            340                 345                 350
Ile Ile Arg His Gly Ala Lys Leu Leu Tyr Ala Phe Ala Glu Ala Thr
        355                 360                 365
Val Pro Lys Val Thr Val Ile Thr Arg Lys Ala Tyr Gly Gly Ala Tyr
    370                 375                 380
Asp Val Met Ser Ser Lys His Leu Cys Gly Asp Thr Asn Tyr Ala Trp
385                 390                 395                 400
Pro Thr Ala Glu Ile Ala Val Met Gly Ala Lys Gly Ala Val Glu Ile
                405                 410                 415
Ile Phe Lys Gly His Glu Asn Val Glu Ala Ala Gln Ala Glu Tyr Ile
            420                 425                 430
Glu Lys Phe Ala Asn Pro Phe Pro Ala Ala Val Arg Gly Phe Val Asp
        435                 440                 445
Asp Ile Ile Gln Pro Ser Ser Thr Arg Ala Arg Ile Cys Cys Asp Leu
    450                 455                 460
Asp Val Leu Ala Ser Lys Lys Val Gln Arg Pro Trp Arg Lys His Ala
465                 470                 475                 480
Asn Ile Pro Leu


<210> 626
<211> 484
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(484)
<223> Xaa = Any Amino Acid

<400> 626
Trp Leu Leu Arg Ser Pro Gly Lys Leu Thr Ala Arg Glu Arg Ile Ser
 1               5                  10                  15
Leu Leu Leu Asp Pro Gly Ser Phe Xaa Glu Ser Asp Met Phe Val Glu
            20                  25                  30
His Arg Cys Ala Asp Phe Gly Met Ala Ala Asp Lys Asn Lys Phe Pro
        35                  40                  45
Gly Asp Ser Val Val Thr Gly Arg Gly Arg Ile Asn Gly Arg Leu Val
    50                  55                  60
Tyr Val Phe Ser Gln Asp Phe Thr Val Phe Gly Gly Ser Leu Ser Gly
65                  70                  75                  80
Ala His Ala Gln Lys Ile Cys Lys Ile Met Asp Gln Ala Ile Thr Val
                85                  90                  95
Gly Ala Pro Val Ile Gly Leu Asn Asp Ser Gly Gly Ala Arg Ile Gln
            100                 105                 110
Glu Gly Val Glu Ser Leu Ala Gly Tyr Ala Asp Ile Phe Leu Arg Asn
        115                 120                 125
Val Thr Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Pro
    130                 135                 140
Cys Ala Gly Gly Ala Val Tyr Ser Pro Ala Leu Thr Asp Phe Thr Phe
145                 150                 155                 160
Met Val Lys Asp Thr Ser Tyr Leu Phe Ile Thr Gly Pro Asp Val Val
                165                 170                 175
Lys Ser Val Thr Asn Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala
            180                 185                 190
Lys Thr His Thr Thr Met Ser Gly Val Ala His Arg Ala Phe Glu Asn
        195                 200                 205
Asp Val Asp Ala Leu Cys Asn Leu Arg Asp Phe Phe Asn Tyr Leu Pro
    210                 215                 220
Leu Ser Ser Gln Asp Pro Ala Pro Val Arg Glu Cys His Asp Pro Ser
225                 230                 235                 240
Asp Arg Leu Val Pro Glu Leu Asp Thr Ile Val Pro Leu Glu Ser Thr
                245                 250                 255
Lys Ala Tyr Asn Met Val Asp Ile Ile His Ser Val Val Asp Glu Arg
            260                 265                 270
Glu Phe Phe Glu Ile Met Pro Asn Tyr Ala Lys Asn Ile Ile Val Gly
        275                 280                 285
Phe Ala Arg Met Asn Gly Arg Thr Val Gly Ile Val Gly Asn Gln Pro
    290                 295                 300
Lys Val Ala Ser Gly Cys Leu Asp Ile Asn Ser Ser Val Lys Gly Ala
305                 310                 315                 320
Arg Phe Val Arg Phe Cys Asp Ala Phe Asn Ile Pro Leu Ile Thr Phe
                325                 330                 335
Val Asp Val Pro Gly Phe Leu Pro Gly Thr Ala Gln Glu Tyr Gly Gly
            340                 345                 350
Ile Ile Arg His Gly Ala Lys Leu Leu Tyr Ala Phe Ala Glu Ala Thr
        355                 360                 365
Val Pro Lys Val Thr Val Ile Thr Arg Lys Ala Tyr Gly Gly Ala Tyr
    370                 375                 380
Asp Val Met Ser Ser Lys His Leu Cys Gly Asp Thr Asn Tyr Ala Trp
385                 390                 395                 400
Pro Thr Ala Glu Ile Ala Val Met Gly Ala Lys Gly Ala Val Glu Ile
                405                 410                 415
Ile Phe Lys Gly His Glu Asn Val Glu Ala Ala Gln Ala Glu Tyr Ile
            420                 425                 430
Glu Lys Phe Ala Asn Pro Phe Pro Ala Ala Val Arg Gly Phe Val Asp
        435                 440                 445
Asp Ile Ile Gln Pro Ser Ser Thr Arg Ala Arg Ile Cys Cys Asp Leu
    450                 455                 460
Asp Val Leu Ala Ser Lys Lys Val Gln Arg Pro Trp Arg Lys His Ala
465                 470                 475                 480
Asn Ile Pro Leu


<210> 627
<211> 539
<212> PRT
<213> Homo sapiens

<400> 627
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45
Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu
    50                  55                  60
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Ser Val
        275                 280                 285
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535

<210> 628
<211> 539
<212> PRT
<213> Homo sapiens

<400> 628
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45
Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu
    50                  55                  60
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Ser Val
        275                 280                 285
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535

<210> 629
<211> 539
<212> PRT
<213> Homo sapiens

<400> 629
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45
Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu
    50                  55                  60
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val
        275                 280                 285
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535

<210> 630
<211> 302
<212> PRT
<213> Homo sapiens

<400> 630
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
 1               5                  10                  15
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
            20                  25                  30
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
        35                  40                  45
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
    50                  55                  60
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
65                  70                  75                  80
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
                85                  90                  95
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
            100                 105                 110
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
        115                 120                 125
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val
    130                 135                 140
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
145                 150                 155                 160
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
                165                 170                 175
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
            180                 185                 190
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
        195                 200                 205
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
    210                 215                 220
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
225                 230                 235                 240
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
                245                 250                 255
Lys Phe Leu Thr Glu Trp Gly Leu Gly Glu Leu Pro Phe Pro Val Arg
            260                 265                 270
Cys Pro Leu Tyr Leu Glu Ile Phe Leu Gln Asn Ser Pro Arg Thr Cys
        275                 280                 285
Asp Phe Ser Met Tyr Ser Gly Cys Pro Glu Asp Arg Ala Val
    290                 295                 300

<210> 631
<211> 2442
<212> PRT
<213> Homo sapiens

<400> 631
Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys
 1               5                  10                  15
Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser
            20                  25                  30
Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly
        35                  40                  45
Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala
    50                  55                  60
Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser
65                  70                  75                  80
Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln
                85                  90                  95
Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met
            100                 105                 110
Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser
        115                 120                 125
Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr
    130                 135                 140
Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly
145                 150                 155                 160
Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys
                165                 170                 175
Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn
            180                 185                 190
Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val
        195                 200                 205
Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met
    210                 215                 220
Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala
225                 230                 235                 240
Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu
                245                 250                 255
Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn
            260                 265                 270
Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met
        275                 280                 285
Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val
    290                 295                 300
Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr
305                 310                 315                 320
Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro
                325                 330                 335
Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys
            340                 345                 350
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
        355                 360                 365
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His
    370                 375                 380
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala
385                 390                 395                 400
Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
                405                 410                 415
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
            420                 425                 430
Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser
        435                 440                 445
Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln
    450                 455                 460
Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser
465                 470                 475                 480
Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro
                485                 490                 495
Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro
            500                 505                 510
Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro
        515                 520                 525
Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn
    530                 535                 540
Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro
545                 550                 555                 560
Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr
                565                 570                 575
Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp
            580                 585                 590
His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu
        595                 600                 605
Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg
    610                 615                 620
Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met
625                 630                 635                 640
Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu
                645                 650                 655
Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg
            660                 665                 670
Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro
        675                 680                 685
Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro
    690                 695                 700
Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly
705                 710                 715                 720
Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln
                725                 730                 735
Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln
            740                 745                 750
Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg
        755                 760                 765
Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met
    770                 775                 780
Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro
785                 790                 795                 800
Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln
                805                 810                 815
Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro
            820                 825                 830
Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val
        835                 840                 845
Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala
    850                 855                 860
Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro
865                 870                 875                 880
Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly
                885                 890                 895
Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr
            900                 905                 910
Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro
        915                 920                 925
Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser
    930                 935                 940
Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro
945                 950                 955                 960
Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser
                965                 970                 975
Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val
            980                 985                 990
Pro Val Leu Glu Met Lys Thr Glu Thr Gln Ala Glu Asp Thr Glu Pro
        995                 1000                1005
Asp Pro Gly Glu Ser Lys Gly Glu Pro Arg Ser Glu Met Met Glu Glu
    1010                1015                1020
Asp Leu Gln Gly Ala Ser Gln Val Lys Glu Glu Thr Asp Ile Ala Glu
1025                1030                1035                1040
Gln Lys Ser Glu Pro Met Glu Val Asp Glu Lys Lys Pro Glu Val Lys
                1045                1050                1055
Val Glu Val Lys Glu Glu Glu Glu Ser Ser Ser Asn Gly Thr Ala Ser
            1060                1065                1070
Gln Ser Thr Ser Pro Ser Gln Pro Arg Lys Lys Ile Phe Lys Pro Glu
        1075                1080                1085
Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln
    1090                1095                1100
Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu
1105                1110                1115                1120
Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn Pro Met Asp Leu Ser
                1125                1130                1135
Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln
            1140                1145                1150
Tyr Val Asp Asp Val Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn
        1155                1160                1165
Arg Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser Lys Leu Ala Glu Val
    1170                1175                1180
Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys
1185                1190                1195                1200
Gly Arg Lys Tyr Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys
                1205                1210                1215
Gln Leu Cys Thr Ile Pro Arg Asp Ala Ala Tyr Tyr Ser Tyr Gln Asn
            1220                1225                1230
Arg Tyr His Phe Cys Glu Lys Cys Phe Thr Glu Ile Gln Gly Glu Asn
        1235                1240                1245
Val Thr Leu Gly Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Ser Lys
    1250                1255                1260
Asp Gln Phe Glu Lys Lys Lys Asn Asp Thr Leu Asp Pro Glu Pro Phe
1265                1270                1275                1280
Val Asp Cys Lys Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu
                1285                1290                1295
His Tyr Asp Ile Ile Trp Pro Ser Gly Phe Val Cys Asp Asn Cys Leu
            1300                1305                1310
Lys Lys Thr Gly Arg Pro Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg
        1315                1320                1325
Leu Gln Thr Thr Arg Leu Gly Asn His Leu Glu Asp Arg Val Asn Lys
    1330                1335                1340
Phe Leu Arg Arg Gln Asn His Pro Glu Ala Gly Glu Val Phe Val Arg
1345                1350                1355                1360
Val Val Ala Ser Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys
                1365                1370                1375
Ser Arg Phe Val Asp Ser Gly Glu Met Ser Glu Ser Phe Pro Tyr Arg
            1380                1385                1390
Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Val Cys
        1395                1400                1405
Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro
    1410                1415                1420
Asn Thr Arg Arg Val Tyr Ile Ser Tyr Leu Asp Ser Ile His Phe Phe
1425                1430                1435                1440
Arg Pro Arg Cys Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly
                1445                1450                1455
Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Val Thr Gly His Ile Trp
            1460                1465                1470
Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro
        1475                1480                1485
Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys
    1490                1495                1500
Lys Met Leu Asp Lys Ala Phe Ala Glu Arg Ile Ile His Asp Tyr Lys
1505                1510                1515                1520
Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu
                1525                1530                1535
Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser
            1540                1545                1550
Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg Lys Lys Glu Glu Ser
        1555                1560                1565
Thr Ala Ala Ser Glu Thr Thr Glu Gly Ser Gln Gly Asp Ser Lys Asn
    1570                1575                1580
Ala Lys Lys Lys Asn Asn Lys Lys Thr Asn Lys Asn Lys Ser Ser Ile
1585                1590                1595                1600
Ser Arg Ala Asn Lys Lys Lys Pro Ser Met Pro Asn Val Ser Asn Asp
                1605                1610                1615
Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe
            1620                1625                1630
Phe Val Ile His Leu His Ala Gly Pro Val Ile Asn Thr Leu Pro Pro
        1635                1640                1645
Ile Val Asp Pro Asp Pro Leu Leu Ser Cys Asp Leu Met Asp Gly Arg
    1650                1655                1660
Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Trp Glu Phe Ser Ser
1665                1670                1675                1680
Leu Arg Arg Ser Lys Trp Ser Thr Leu Cys Met Leu Val Glu Leu His
                1685                1690                1695
Thr Gln Gly Gln Asp Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His
            1700                1705                1710
His Val Glu Thr Arg Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu
        1715                1720                1725
Cys Ile Asn Cys Tyr Asn Thr Lys Ser His Ala His Lys Met Val Lys
    1730                1735                1740
Trp Gly Leu Gly Leu Asp Asp Glu Gly Ser Ser Gln Gly Glu Pro Gln
1745                1750                1755                1760
Ser Lys Ser Pro Gln Glu Ser Arg Arg Val Ser Ile Gln Arg Cys Ile
                1765                1770                1775
Gln Ser Leu Val His Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu
            1780                1785                1790
Pro Ser Cys Gln Lys Met Lys Arg Val Val Gln His Thr Lys Gly Cys
        1795                1800                1805
Lys Arg Lys Thr Asn Gly Gly Cys Pro Val Cys Lys Gln Leu Ile Ala
    1810                1815                1820
Leu Cys Cys Tyr His Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val
1825                1830                1835                1840
Pro Phe Cys Leu Asn Ile Lys His Lys Leu Arg Gln Gln Gln Ile Gln
                1845                1850                1855
His Arg Leu Gln Gln Ala Gln Leu Met Arg Arg Arg Met Ala Thr Met
            1860                1865                1870
Asn Thr Arg Asn Val Pro Gln Gln Ser Leu Pro Ser Pro Thr Ser Ala
        1875                1880                1885
Pro Pro Gly Thr Pro Thr Gln Gln Pro Ser Thr Pro Gln Thr Pro Gln
    1890                1895                1900
Pro Pro Ala Gln Pro Gln Pro Ser Pro Val Ser Met Ser Pro Ala Gly
1905                1910                1915                1920
Phe Pro Ser Val Ala Arg Thr Gln Pro Pro Thr Thr Val Ser Thr Gly
                1925                1930                1935
Lys Pro Thr Ser Gln Val Pro Ala Pro Pro Pro Pro Ala Gln Pro Pro
            1940                1945                1950
Pro Ala Ala Val Glu Ala Ala Arg Gln Ile Glu Arg Glu Ala Gln Gln
        1955                1960                1965
Gln Gln His Leu Tyr Arg Val Asn Ile Asn Asn Ser Met Pro Pro Gly
    1970                1975                1980
Arg Thr Gly Met Gly Thr Pro Gly Ser Gln Met Ala Pro Val Ser Leu
1985                1990                1995                2000
Asn Val Pro Arg Pro Asn Gln Val Ser Gly Pro Val Met Pro Ser Met
                2005                2010                2015
Pro Pro Gly Gln Trp Gln Gln Ala Pro Leu Pro Gln Gln Gln Pro Met
            2020                2025                2030
Pro Gly Leu Pro Arg Pro Val Ile Ser Met Gln Ala Gln Ala Ala Val
        2035                2040                2045
Ala Gly Pro Arg Met Pro Ser Val Gln Pro Pro Arg Ser Ile Ser Pro
    2050                2055                2060
Ser Ala Leu Gln Asp Leu Leu Arg Thr Leu Lys Ser Pro Ser Ser Pro
2065                2070                2075                2080
Gln Gln Gln Gln Gln Val Leu Asn Ile Leu Lys Ser Asn Pro Gln Leu
                2085                2090                2095
Met Ala Ala Phe Ile Lys Gln Arg Thr Ala Lys Tyr Val Ala Asn Gln
            2100                2105                2110
Pro Gly Met Gln Pro Gln Pro Gly Leu Gln Ser Gln Pro Gly Met Gln
        2115                2120                2125
Pro Gln Pro Gly Met His Gln Gln Pro Ser Leu Gln Asn Leu Asn Ala
    2130                2135                2140
Met Gln Ala Gly Val Pro Arg Pro Gly Val Pro Pro Gln Gln Gln Ala
2145                2150                2155                2160
Met Gly Gly Leu Asn Pro Gln Gly Gln Ala Leu Asn Ile Met Asn Pro
                2165                2170                2175
Gly His Asn Pro Asn Met Ala Ser Met Asn Pro Gln Tyr Arg Glu Met
            2180                2185                2190
Leu Arg Arg Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        2195                2200                2205
Gln Gln Gln Gln Gln Gln Gln Gln Gly Ser Ala Gly Met Ala Gly Gly
    2210                2215                2220
Met Ala Gly His Gly Gln Phe Gln Gln Pro Gln Gly Pro Gly Gly Tyr
2225                2230                2235                2240
Pro Pro Ala Met Gln Gln Gln Gln Arg Met Gln Gln His Leu Pro Leu
                2245                2250                2255
Gln Gly Ser Ser Met Gly Gln Met Ala Ala Gln Met Gly Gln Leu Gly
            2260                2265                2270
Gln Met Gly Gln Pro Gly Leu Gly Ala Asp Ser Thr Pro Asn Ile Gln
        2275                2280                2285
Gln Ala Leu Gln Gln Arg Ile Leu Gln Gln Gln Gln Met Lys Gln Gln
    2290                2295                2300
Ile Gly Ser Pro Gly Gln Pro Asn Pro Met Ser Pro Gln Gln His Met
2305                2310                2315                2320
Leu Ser Gly Gln Pro Gln Ala Ser His Leu Pro Gly Gln Gln Ile Ala
                2325                2330                2335
Thr Ser Leu Ser Asn Gln Val Arg Ser Pro Ala Pro Val Gln Ser Pro
            2340                2345                2350
Arg Pro Gln Ser Gln Pro Pro His Ser Ser Pro Ser Pro Arg Ile Gln
        2355                2360                2365
Pro Gln Pro Ser Pro His His Val Ser Pro Gln Thr Gly Ser Pro His
    2370                2375                2380
Pro Gly Leu Ala Val Thr Met Ala Ser Ser Ile Asp Gln Gly His Leu
2385                2390                2395                2400
Gly Asn Pro Glu Gln Ser Ala Met Leu Pro Gln Leu Asn Thr Pro Ser
                2405                2410                2415
Arg Ser Ala Leu Ser Ser Glu Leu Ser Leu Val Gly Asp Thr Thr Gly
            2420                2425                2430
Asp Thr Leu Glu Lys Phe Val Glu Gly Leu
        2435                2440

<210> 632
<211> 555
<212> PRT
<213> Homo sapiens

<400> 632
Met Gly Ile Thr Gly Asn Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln
 1               5                  10                  15
Ala Gly Gly Gln Pro Met Gly Ala Thr Gly Val Asn Pro Gln Leu Ala
            20                  25                  30
Ser Lys Gln Ser Met Val Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile
        35                  40                  45
Lys Asn Thr Ser Val Thr Asn Val Pro Asn Met Ser Gln Met Gln Thr
    50                  55                  60
Ser Val Gly Ile Val Pro Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala
65                  70                  75                  80
Asp Pro Glu Lys Arg Lys Leu Ile Gln Gln Gln Leu Val Leu Leu Leu
                85                  90                  95
His Ala His Lys Cys Gln Arg Arg Glu Gln Ala Asn Gly Glu Val Arg
            100                 105                 110
Ala Cys Ser Leu Pro His Cys Arg Thr Met Lys Asn Val Leu Asn His
        115                 120                 125
Met Thr His Cys Gln Ala Gly Lys Ala Cys Gln Val Ala His Cys Ala
    130                 135                 140
Ser Ser Arg Gln Ile Ile Ser His Trp Lys Asn Cys Thr Arg His Asp
145                 150                 155                 160
Cys Pro Val Cys Leu Pro Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln
                165                 170                 175
Gln Thr Ile Leu Gly Ser Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly
            180                 185                 190
Ser Val Gly Thr Gly Gln Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn
        195                 200                 205
Pro Ile Asp Pro Ser Ser Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu
    210                 215                 220
Pro Tyr Met Asn Gln Pro Gln Thr Gln Leu Gln Pro Gln Val Pro Gly
225                 230                 235                 240
Gln Gln Pro Ala Gln Pro Gln Thr His Gln Gln Met Arg Thr Leu Asn
                245                 250                 255
Pro Leu Gly Asn Asn Pro Met Asn Ile Pro Ala Gly Gly Ile Thr Thr
            260                 265                 270
Asp Gln Gln Pro Pro Asn Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser
        275                 280                 285
Leu Gly Ala Thr Asn Pro Leu Met Asn Asp Gly Ser Asn Ser Gly Asn
    290                 295                 300
Ile Gly Thr Leu Ser Thr Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr
305                 310                 315                 320
Gly Val Arg Lys Gly Trp His Glu His Val Thr Gln Asp Leu Arg Ser
                325                 330                 335
His Leu Val His Lys Leu Val Gln Ala Ile Phe Pro Thr Pro Asp Pro
            340                 345                 350
Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu Val Ala Tyr Ala Lys
        355                 360                 365
Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr
    370                 375                 380
Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu
385                 390                 395                 400
Glu Lys Arg Arg Ser Arg Leu His Lys Gln Gly Ile Leu Gly Asn Gln
                405                 410                 415
Pro Ala Leu Pro Ala Pro Gly Ala Gln Pro Pro Val Ile Pro Gln Ala
            420                 425                 430
Gln Pro Val Arg Pro Pro Asn Gly Pro Leu Ser Leu Pro Val Asn Arg
        435                 440                 445
Met Gln Val Ser Gln Gly Met Asn Ser Phe Asn Pro Met Ser Leu Gly
    450                 455                 460
Asn Val Gln Leu Pro Gln Ala Pro Met Gly Pro Arg Ala Ala Ser Pro
465                 470                 475                 480
Met Asn His Ser Val Gln Met Asn Ser Met Gly Ser Val Pro Gly Met
                485                 490                 495
Ala Ile Ser Pro Ser Arg Met Pro Gln Pro Pro Asn Met Met Gly Ala
            500                 505                 510
His Thr Asn Asn Met Met Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu
        515                 520                 525
Pro Gln Asn Gln Phe Pro Ser Ser Ser Gly Ala Met Ser Val Gly Met
    530                 535                 540
Gly Gln Pro Pro Ala Gln Thr Gly Val Ser Gln
545                 550                 555

<210> 633
<211> 2442
<212> PRT
<213> Homo sapiens

<400> 633
Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys
 1               5                  10                  15
Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser
            20                  25                  30
Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly
        35                  40                  45
Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala
    50                  55                  60
Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser
65                  70                  75                  80
Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln
                85                  90                  95
Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met
            100                 105                 110
Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser
        115                 120                 125
Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr
    130                 135                 140
Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly
145                 150                 155                 160
Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys
                165                 170                 175
Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn
            180                 185                 190
Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val
        195                 200                 205
Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met
    210                 215                 220
Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala
225                 230                 235                 240
Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu
                245                 250                 255
Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn
            260                 265                 270
Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met
        275                 280                 285
Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val
    290                 295                 300
Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr
305                 310                 315                 320
Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro
                325                 330                 335
Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys
            340                 345                 350
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
        355                 360                 365
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His
    370                 375                 380
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala
385                 390                 395                 400
Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
                405                 410                 415
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
            420                 425                 430
Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser
        435                 440                 445
Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln
    450                 455                 460
Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser
465                 470                 475                 480
Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro
                485                 490                 495
Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro
            500                 505                 510
Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro
        515                 520                 525
Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn
    530                 535                 540
Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro
545                 550                 555                 560
Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr
                565                 570                 575
Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp
            580                 585                 590
His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu
        595                 600                 605
Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg
    610                 615                 620
Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met
625                 630                 635                 640
Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu
                645                 650                 655
Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg
            660                 665                 670
Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro
        675                 680                 685
Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro
    690                 695                 700
Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly
705                 710                 715                 720
Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln
                725                 730                 735
Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln
            740                 745                 750
Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg
        755                 760                 765
Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met
    770                 775                 780
Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro
785                 790                 795                 800
Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln
                805                 810                 815
Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro
            820                 825                 830
Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val
        835                 840                 845
Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala
    850                 855                 860
Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro
865                 870                 875                 880
Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly
                885                 890                 895
Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr
            900                 905                 910
Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro
        915                 920                 925
Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser
    930                 935                 940
Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro
945                 950                 955                 960
Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser
                965                 970                 975
Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val
            980                 985                 990
Pro Val Leu Glu Met Lys Thr Glu Thr Gln Ala Glu Asp Thr Glu Pro
        995                 1000                1005
Asp Pro Gly Glu Ser Lys Gly Glu Pro Arg Ser Glu Met Met Glu Glu
    1010                1015                1020
Asp Leu Gln Gly Ala Ser Gln Val Lys Glu Glu Thr Asp Ile Ala Glu
1025                1030                1035                1040
Gln Lys Ser Glu Pro Met Glu Val Asp Glu Lys Lys Pro Glu Val Lys
                1045                1050                1055
Val Glu Val Lys Glu Glu Glu Glu Ser Ser Ser Asn Gly Thr Ala Ser
            1060                1065                1070
Gln Ser Thr Ser Pro Ser Gln Pro Arg Lys Lys Ile Phe Lys Pro Glu
        1075                1080                1085
Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln
    1090                1095                1100
Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu
1105                1110                1115                1120
Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn Pro Met Asp Leu Ser
                1125                1130                1135
Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln
            1140                1145                1150
Tyr Val Asp Asp Val Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn
        1155                1160                1165
Arg Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser Lys Leu Ala Glu Val
    1170                1175                1180
Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys
1185                1190                1195                1200
Gly Arg Lys Tyr Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys
                1205                1210                1215
Gln Leu Cys Thr Ile Pro Arg Asp Ala Ala Tyr Tyr Ser Tyr Gln Asn
            1220                1225                1230
Arg Tyr His Phe Cys Glu Lys Cys Phe Thr Glu Ile Gln Gly Glu Asn
        1235                1240                1245
Val Thr Leu Gly Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Ser Lys
    1250                1255                1260
Asp Gln Phe Glu Lys Lys Lys Asn Asp Thr Leu Asp Pro Glu Pro Phe
1265                1270                1275                1280
Val Asp Cys Lys Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu
                1285                1290                1295
His Tyr Asp Ile Ile Trp Pro Ser Gly Phe Val Cys Asp Asn Cys Leu
            1300                1305                1310
Lys Lys Thr Gly Arg Pro Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg
        1315                1320                1325
Leu Gln Thr Thr Arg Leu Gly Asn His Leu Glu Asp Arg Val Asn Lys
    1330                1335                1340
Phe Leu Arg Arg Gln Asn His Pro Glu Ala Gly Glu Val Phe Val Arg
1345                1350                1355                1360
Val Val Ala Ser Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys
                1365                1370                1375
Ser Arg Phe Val Asp Ser Gly Glu Met Ser Glu Ser Phe Pro Tyr Arg
            1380                1385                1390
Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Val Cys
        1395                1400                1405
Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro
    1410                1415                1420
Asn Thr Arg Arg Val Tyr Ile Ser Tyr Leu Asp Ser Ile His Phe Phe
1425                1430                1435                1440
Arg Pro Arg Cys Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly
                1445                1450                1455
Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Val Thr Gly His Ile Trp
            1460                1465                1470
Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro
        1475                1480                1485
Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys
    1490                1495                1500
Lys Met Leu Asp Lys Ala Phe Ala Glu Arg Ile Ile His Asp Tyr Lys
1505                1510                1515                1520
Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu
                1525                1530                1535
Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser
            1540                1545                1550
Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg Lys Lys Glu Glu Ser
        1555                1560                1565
Thr Ala Ala Ser Glu Thr Thr Glu Gly Ser Gln Gly Asp Ser Lys Asn
    1570                1575                1580
Ala Lys Lys Lys Asn Asn Lys Lys Thr Asn Lys Asn Lys Ser Ser Ile
1585                1590                1595                1600
Ser Arg Ala Asn Lys Lys Lys Pro Ser Met Pro Asn Val Ser Asn Asp
                1605                1610                1615
Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe
            1620                1625                1630
Phe Val Ile His Leu His Ala Gly Pro Val Ile Asn Thr Leu Pro Pro
        1635                1640                1645
Ile Val Asp Pro Asp Pro Leu Leu Ser Cys Asp Leu Met Asp Gly Arg
    1650                1655                1660
Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Trp Glu Phe Ser Ser
1665                1670                1675                1680
Leu Arg Arg Ser Lys Trp Ser Thr Leu Cys Met Leu Val Glu Leu His
                1685                1690                1695
Thr Gln Gly Gln Asp Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His
            1700                1705                1710
His Val Glu Thr Arg Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu
        1715                1720                1725
Cys Ile Asn Cys Tyr Asn Thr Lys Ser His Ala His Lys Met Val Lys
    1730                1735                1740
Trp Gly Leu Gly Leu Asp Asp Glu Gly Ser Ser Gln Gly Glu Pro Gln
1745                1750                1755                1760
Ser Lys Ser Pro Gln Glu Ser Arg Arg Leu Ser Ile Gln Arg Cys Ile
                1765                1770                1775
Gln Ser Leu Val His Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu
            1780                1785                1790
Pro Ser Cys Gln Lys Met Lys Arg Val Val Gln His Thr Lys Gly Cys
        1795                1800                1805
Lys Arg Lys Thr Asn Gly Gly Cys Pro Val Cys Lys Gln Leu Ile Ala
    1810                1815                1820
Leu Cys Cys Tyr His Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val
1825                1830                1835                1840
Pro Phe Cys Leu Asn Ile Lys His Lys Leu Arg Gln Gln Gln Ile Gln
                1845                1850                1855
His Arg Leu Gln Gln Ala Gln Leu Met Arg Arg Arg Met Ala Thr Met
            1860                1865                1870
Asn Thr Arg Asn Val Pro Gln Gln Ser Leu Pro Ser Pro Thr Ser Ala
        1875                1880                1885
Pro Pro Gly Thr Pro Thr Gln Gln Pro Ser Thr Pro Gln Thr Pro Gln
    1890                1895                1900
Pro Pro Ala Gln Pro Gln Pro Ser Pro Val Ser Met Ser Pro Ala Gly
1905                1910                1915                1920
Phe Pro Ser Val Ala Arg Thr Gln Pro Pro Thr Thr Val Ser Thr Gly
                1925                1930                1935
Lys Pro Thr Ser Gln Val Pro Ala Pro Pro Pro Pro Ala Gln Pro Pro
            1940                1945                1950
Pro Ala Ala Val Glu Ala Ala Arg Gln Ile Glu Arg Glu Ala Gln Gln
        1955                1960                1965
Gln Gln His Leu Tyr Arg Val Asn Ile Asn Asn Ser Met Pro Pro Gly
    1970                1975                1980
Arg Thr Gly Met Gly Thr Pro Gly Ser Gln Met Ala Pro Val Ser Leu
1985                1990                1995                2000
Asn Val Pro Arg Pro Asn Gln Val Ser Gly Pro Val Met Pro Ser Met
                2005                2010                2015
Pro Pro Gly Gln Trp Gln Gln Ala Pro Leu Pro Gln Gln Gln Pro Met
            2020                2025                2030
Pro Gly Leu Pro Arg Pro Val Ile Ser Met Gln Ala Gln Ala Ala Val
        2035                2040                2045
Ala Gly Pro Arg Met Pro Ser Val Gln Pro Pro Arg Ser Ile Ser Pro
    2050                2055                2060
Ser Ala Leu Gln Asp Leu Leu Arg Thr Leu Lys Ser Pro Ser Ser Pro
2065                2070                2075                2080
Gln Gln Gln Gln Gln Val Leu Asn Ile Leu Lys Ser Asn Pro Gln Leu
                2085                2090                2095
Met Ala Ala Phe Ile Lys Gln Arg Thr Ala Lys Tyr Val Ala Asn Gln
            2100                2105                2110
Pro Gly Met Gln Pro Gln Pro Gly Leu Gln Ser Gln Pro Gly Met Gln
        2115                2120                2125
Pro Gln Pro Gly Met His Gln Gln Pro Ser Leu Gln Asn Leu Asn Ala
    2130                2135                2140
Met Gln Ala Gly Val Pro Arg Pro Gly Val Pro Pro Gln Gln Gln Ala
2145                2150                2155                2160
Met Gly Gly Leu Asn Pro Gln Gly Gln Ala Leu Asn Ile Met Asn Pro
                2165                2170                2175
Gly His Asn Pro Asn Met Ala Ser Met Asn Pro Gln Tyr Arg Glu Met
            2180                2185                2190
Leu Arg Arg Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        2195                2200                2205
Gln Gln Gln Gln Gln Gln Gln Gln Gly Ser Ala Gly Met Ala Gly Gly
    2210                2215                2220
Met Ala Gly His Gly Gln Phe Gln Gln Pro Gln Gly Pro Gly Gly Tyr
2225                2230                2235                2240
Pro Pro Ala Met Gln Gln Gln Gln Arg Met Gln Gln His Leu Pro Leu
                2245                2250                2255
Gln Gly Ser Ser Met Gly Gln Met Ala Ala Gln Met Gly Gln Leu Gly
            2260                2265                2270
Gln Met Gly Gln Pro Gly Leu Gly Ala Asp Ser Thr Pro Asn Ile Gln
        2275                2280                2285
Gln Ala Leu Gln Gln Arg Ile Leu Gln Gln Gln Gln Met Lys Gln Gln
    2290                2295                2300
Ile Gly Ser Pro Gly Gln Pro Asn Pro Met Ser Pro Gln Gln His Met
2305                2310                2315                2320
Leu Ser Gly Gln Pro Gln Ala Ser His Leu Pro Gly Gln Gln Ile Ala
                2325                2330                2335
Thr Ser Leu Ser Asn Gln Val Arg Ser Pro Ala Pro Val Gln Ser Pro
            2340                2345                2350
Arg Pro Gln Ser Gln Pro Pro His Ser Ser Pro Ser Pro Arg Ile Gln
        2355                2360                2365
Pro Gln Pro Ser Pro His His Val Ser Pro Gln Thr Gly Ser Pro His
    2370                2375                2380
Pro Gly Leu Ala Val Thr Met Ala Ser Ser Ile Asp Gln Gly His Leu
2385                2390                2395                2400
Gly Asn Pro Glu Gln Ser Ala Met Leu Pro Gln Leu Asn Thr Pro Ser
                2405                2410                2415
Arg Ser Ala Leu Ser Ser Glu Leu Ser Leu Val Gly Asp Thr Thr Gly
            2420                2425                2430
Asp Thr Leu Glu Lys Phe Val Glu Gly Leu
        2435                2440

<210> 634
<211> 2414
<212> PRT
<213> Homo sapiens

<400> 634
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro
 1               5                  10                  15
Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp
            20                  25                  30
Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile
        35                  40                  45
Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu
    50                  55                  60
Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln
65                  70                  75                  80
Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly
                85                  90                  95
Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser
            100                 105                 110
Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln
        115                 120                 125
Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn
    130                 135                 140
Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln
145                 150                 155                 160
Pro Ala Met Gly Met Asn Thr Gly Thr Asn Ala Gly Met Asn Pro Gly
                165                 170                 175
Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met
            180                 185                 190
Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asp Met Gln Tyr Pro
        195                 200                 205
Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln
    210                 215                 220
Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln
225                 230                 235                 240
Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro
                245                 250                 255
Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu
            260                 265                 270
Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala
        275                 280                 285
Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln
    290                 295                 300
Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala
305                 310                 315                 320
Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys
                325                 330                 335
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
            340                 345                 350
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His
        355                 360                 365
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser
    370                 375                 380
Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
385                 390                 395                 400
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
                405                 410                 415
Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly
            420                 425                 430
Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln
        435                 440                 445
Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile
    450                 455                 460
Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met
465                 470                 475                 480
Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro
                485                 490                 495
Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser
            500                 505                 510
Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu
        515                 520                 525
Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met
    530                 535                 540
Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala
545                 550                 555                 560
Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr
                565                 570                 575
Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe
            580                 585                 590
Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu
        595                 600                 605
Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn
    610                 615                 620
Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile
625                 630                 635                 640
Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn
                645                 650                 655
Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly
            660                 665                 670
Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu
        675                 680                 685
Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro
    690                 695                 700
Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met
705                 710                 715                 720
Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His
                725                 730                 735
Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly
            740                 745                 750
Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr
        755                 760                 765
Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro
    770                 775                 780
Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser
785                 790                 795                 800
Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His
                805                 810                 815
Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro
            820                 825                 830
Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser
        835                 840                 845
Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro
    850                 855                 860
Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro
865                 870                 875                 880
Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln
                885                 890                 895
Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln
            900                 905                 910
Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Asn
        915                 920                 925
Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala
    930                 935                 940
Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr
945                 950                 955                 960
Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val
                965                 970                 975
Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr
            980                 985                 990
Gln Pro Glu Asp Ile Ser Glu Ser Lys Val Glu Asp Cys Lys Met Glu
        995                 1000                1005
Ser Thr Glu Thr Glu Glu Arg Ser Thr Glu Leu Lys Thr Glu Ile Lys
    1010                1015                1020
Glu Glu Glu Asp Gln Pro Ser Thr Ser Ala Thr Gln Ser Ser Pro Ala
1025                1030                1035                1040
Pro Gly Gln Ser Lys Lys Lys Ile Phe Lys Pro Glu Glu Leu Arg Gln
                1045                1050                1055
Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp Pro Glu Ser
            1060                1065                1070
Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly Ile Pro Asp
        1075                1080                1085
Tyr Phe Asp Ile Val Lys Ser Pro Met Asp Leu Ser Thr Ile Lys Arg
    1090                1095                1100
Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr Val Asp Asp
1105                1110                1115                1120
Ile Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg Lys Thr Ser
                1125                1130                1135
Arg Val Tyr Lys Tyr Cys Ser Lys Leu Ser Glu Val Phe Glu Gln Glu
            1140                1145                1150
Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly Arg Lys Leu
        1155                1160                1165
Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln Leu Cys Thr
    1170                1175                1180
Ile Pro Arg Asp Ala Thr Tyr Tyr Ser Tyr Gln Asn Arg Tyr His Phe
1185                1190                1195                1200
Cys Glu Lys Cys Phe Asn Glu Ile Gln Gly Glu Ser Val Ser Leu Gly
                1205                1210                1215
Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Asn Lys Glu Gln Phe Ser
            1220                1225                1230
Lys Arg Lys Asn Asp Thr Leu Asp Pro Glu Leu Phe Val Glu Cys Thr
        1235                1240                1245
Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu His His Glu Ile
    1250                1255                1260
Ile Trp Pro Ala Gly Phe Val Cys Asp Gly Cys Leu Lys Lys Ser Ala
1265                1270                1275                1280
Arg Thr Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Pro Ser Thr
                1285                1290                1295
Arg Leu Gly Thr Phe Leu Glu Asn Arg Val Asn Asp Phe Leu Arg Arg
            1300                1305                1310
Gln Asn His Pro Glu Ser Gly Glu Val Thr Val Arg Val Val His Ala
        1315                1320                1325
Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys Ala Arg Phe Val
    1330                1335                1340
Asp Ser Gly Glu Met Ala Glu Ser Phe Pro Tyr Arg Thr Lys Ala Leu
1345                1350                1355                1360
Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Leu Cys Phe Phe Gly Met
                1365                1370                1375
His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Gln Arg Arg
            1380                1385                1390
Val Tyr Ile Ser Tyr Leu Asp Ser Val His Phe Phe Arg Pro Lys Cys
        1395                1400                1405
Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly Tyr Leu Glu Tyr
    1410                1415                1420
Val Lys Lys Leu Gly Tyr Thr Thr Gly His Ile Trp Ala Cys Pro Pro
1425                1430                1435                1440
Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro Pro Asp Gln Lys
                1445                1450                1455
Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys Lys Met Leu Asp
            1460                1465                1470
Lys Ala Val Ser Glu Arg Ile Val His Asp Tyr Lys Asp Ile Phe Lys
        1475                1480                1485
Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu Leu Pro Tyr Phe
    1490                1495                1500
Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser Ile Lys Glu Leu
1505                1510                1515                1520
Glu Gln Glu Glu Glu Glu Arg Lys Arg Glu Glu Asn Thr Ser Asn Glu
                1525                1530                1535
Ser Thr Asp Val Thr Lys Gly Asp Ser Lys Asn Ala Lys Lys Lys Asn
            1540                1545                1550
Asn Lys Lys Thr Ser Lys Asn Lys Ser Ser Leu Ser Arg Gly Asn Lys
        1555                1560                1565
Lys Lys Pro Gly Met Pro Asn Val Ser Asn Asp Leu Ser Gln Lys Leu
    1570                1575                1580
Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe Phe Val Ile Arg Leu
1585                1590                1595                1600
Ile Ala Gly Pro Ala Ala Asn Ser Leu Pro Pro Ile Val Asp Pro Asp
                1605                1610                1615
Pro Leu Ile Pro Cys Asp Leu Met Asp Gly Arg Asp Ala Phe Leu Thr
            1620                1625                1630
Leu Ala Arg Asp Lys His Leu Glu Phe Ser Ser Leu Arg Arg Ala Gln
        1635                1640                1645
Trp Ser Thr Met Cys Met Leu Val Glu Leu His Thr Gln Ser Gln Asp
    1650                1655                1660
Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His His Val Glu Thr Arg
1665                1670                1675                1680
Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu Cys Ile Thr Cys Tyr
                1685                1690                1695
Asn Thr Lys Asn His Asp His Lys Met Glu Lys Leu Gly Leu Gly Leu
            1700                1705                1710
Asp Asp Glu Ser Asn Asn Gln Gln Ala Ala Ala Thr Gln Ser Pro Gly
        1715                1720                1725
Asp Ser Arg Arg Leu Ser Ile Gln Arg Cys Ile Gln Ser Leu Val His
    1730                1735                1740
Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu Pro Ser Cys Gln Lys
1745                1750                1755                1760
Met Lys Arg Val Val Gln His Thr Lys Gly Cys Lys Arg Lys Thr Asn
                1765                1770                1775
Gly Gly Cys Pro Ile Cys Lys Gln Leu Ile Ala Leu Cys Cys Tyr His
            1780                1785                1790
Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val Pro Phe Cys Leu Asn
        1795                1800                1805
Ile Lys Gln Lys Leu Arg Gln Gln Gln Leu Gln His Arg Leu Gln Gln
    1810                1815                1820
Ala Gln Met Leu Arg Arg Arg Met Ala Ser Met Gln Arg Thr Gly Val
1825                1830                1835                1840
Val Gly Gln Gln Gln Gly Leu Pro Ser Pro Thr Pro Ala Thr Pro Thr
                1845                1850                1855
Thr Pro Thr Gly Gln Gln Pro Thr Thr Pro Gln Thr Pro Gln Pro Thr
            1860                1865                1870
Ser Gln Pro Gln Pro Thr Pro Pro Asn Ser Met Pro Pro Tyr Leu Pro
        1875                1880                1885
Arg Thr Gln Ala Ala Gly Pro Val Ser Gln Gly Lys Ala Ala Gly Gln
    1890                1895                1900
Val Thr Pro Pro Thr Pro Pro Gln Thr Ala Gln Pro Pro Leu Pro Gly
1905                1910                1915                1920
Pro Pro Pro Thr Ala Val Glu Met Ala Met Gln Ile Gln Arg Ala Ala
                1925                1930                1935
Glu Thr Gln Arg Gln Met Ala His Val Gln Ile Phe Gln Arg Pro Ile
            1940                1945                1950
Gln His Gln Met Pro Pro Met Thr Pro Met Ala Pro Met Gly Met Asn
        1955                1960                1965
Pro Pro Pro Met Thr Arg Gly Pro Ser Gly His Leu Glu Pro Gly Met
    1970                1975                1980
Gly Pro Thr Gly Met Gln Gln Gln Pro Pro Trp Ser Gln Gly Gly Leu
1985                1990                1995                2000
Pro Gln Pro Gln Gln Leu Gln Ser Gly Met Pro Arg Pro Ala Met Met
                2005                2010                2015
Ser Val Ala Gln His Gly Gln Pro Leu Asn Met Ala Pro Gln Pro Gly
            2020                2025                2030
Leu Gly Gln Val Gly Ile Ser Pro Leu Lys Pro Gly Thr Val Ser Gln
        2035                2040                2045
Gln Ala Leu Gln Asn Leu Leu Arg Thr Leu Arg Ser Pro Ser Ser Pro
    2050                2055                2060
Leu Gln Gln Gln Gln Val Leu Ser Ile Leu His Ala Asn Pro Gln Leu
2065                2070                2075                2080
Leu Ala Ala Phe Ile Lys Gln Arg Ala Ala Lys Tyr Ala Asn Ser Asn
                2085                2090                2095
Pro Gln Pro Ile Pro Gly Gln Pro Gly Met Pro Gln Gly Gln Pro Gly
            2100                2105                2110
Leu Gln Pro Pro Thr Met Pro Gly Gln Gln Gly Val His Ser Asn Pro
        2115                2120                2125
Ala Met Gln Asn Met Asn Pro Met Gln Ala Gly Val Gln Arg Ala Gly
    2130                2135                2140
Leu Pro Gln Gln Gln Pro Gln Gln Gln Leu Gln Pro Pro Met Gly Gly
2145                2150                2155                2160
Met Ser Pro Gln Ala Gln Gln Met Asn Met Asn His Asn Thr Met Pro
                2165                2170                2175
Ser Gln Phe Arg Asp Ile Leu Arg Arg Gln Gln Met Met Gln Gln Gln
            2180                2185                2190
Gln Gln Gln Gly Ala Gly Pro Gly Ile Gly Pro Gly Met Ala Asn His
        2195                2200                2205
Asn Gln Phe Gln Gln Pro Gln Gly Val Gly Tyr Pro Pro Gln Pro Gln
    2210                2215                2220
Gln Arg Met Gln His His Met Gln Gln Met Gln Gln Gly Asn Met Gly
2225                2230                2235                2240
Gln Ile Gly Gln Leu Pro Gln Ala Leu Gly Ala Glu Ala Gly Ala Ser
                2245                2250                2255
Leu Gln Ala Tyr Gln Gln Arg Leu Leu Gln Gln Gln Met Gly Ser Pro
            2260                2265                2270
Val Gln Pro Asn Pro Met Ser Pro Gln Gln His Met Leu Pro Asn Gln
        2275                2280                2285
Ala Gln Ser Pro His Leu Gln Gly Gln Gln Ile Pro Asn Ser Leu Ser
    2290                2295                2300
Asn Gln Val Arg Ser Pro Gln Pro Val Pro Ser Pro Arg Pro Gln Ser
2305                2310                2315                2320
Gln Pro Pro His Ser Ser Pro Ser Pro Arg Met Gln Pro Gln Pro Ser
                2325                2330                2335
Pro His His Val Ser Pro Gln Thr Ser Ser Pro His Pro Gly Leu Val
            2340                2345                2350
Ala Ala Gln Ala Asn Pro Met Glu Gln Gly His Phe Ala Ser Pro Asp
        2355                2360                2365
Gln Asn Ser Met Leu Ser Gln Leu Ala Ser Asn Pro Gly Met Ala Asn
    2370                2375                2380
Leu His Gly Ala Ser Ala Thr Asp Leu Gly Leu Ser Thr Asp Asn Ser
2385                2390                2395                2400
Asp Leu Asn Ser Asn Leu Ser Gln Ser Thr Leu Asp Ile His
                2405                2410

<210> 635
<211> 963
<212> PRT
<213> Homo sapiens

<400> 635
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro
 1               5                  10                  15
Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp
            20                  25                  30
Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile
        35                  40                  45
Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu
    50                  55                  60
Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln
65                  70                  75                  80
Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly
                85                  90                  95
Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser
            100                 105                 110
Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln
        115                 120                 125
Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn
    130                 135                 140
Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln
145                 150                 155                 160
Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly
                165                 170                 175
Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met
            180                 185                 190
Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro
        195                 200                 205
Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln
    210                 215                 220
Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln
225                 230                 235                 240
Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro
                245                 250                 255
Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu
            260                 265                 270
Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala
        275                 280                 285
Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln
    290                 295                 300
Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala
305                 310                 315                 320
Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys
                325                 330                 335
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
            340                 345                 350
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His
        355                 360                 365
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser
    370                 375                 380
Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
385                 390                 395                 400
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
                405                 410                 415
Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly
            420                 425                 430
Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln
        435                 440                 445
Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile
    450                 455                 460
Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met
465                 470                 475                 480
Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro
                485                 490                 495
Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser
            500                 505                 510
Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu
        515                 520                 525
Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met
    530                 535                 540
Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala
545                 550                 555                 560
Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr
                565                 570                 575
Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe
            580                 585                 590
Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu
        595                 600                 605
Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn
    610                 615                 620
Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile
625                 630                 635                 640
Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn
                645                 650                 655
Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly
            660                 665                 670
Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu
        675                 680                 685
Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro
    690                 695                 700
Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met
705                 710                 715                 720
Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His
                725                 730                 735
Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly
            740                 745                 750
Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr
        755                 760                 765
Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro
    770                 775                 780
Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser
785                 790                 795                 800
Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His
                805                 810                 815
Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro
            820                 825                 830
Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser
        835                 840                 845
Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro
    850                 855                 860
Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro
865                 870                 875                 880
Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln
                885                 890                 895
Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln
            900                 905                 910
Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr
        915                 920                 925
Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala
    930                 935                 940
Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr
945                 950                 955                 960
Glu Val Asn


<210> 636
<211> 58
<212> PRT
<213> Homo sapiens

<400> 636
Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys
 1               5                  10                  15
Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn Met Leu
            20                  25                  30
Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly Pro Asn
        35                  40                  45
Met Gly Gln Pro Gln Pro Gly Met Thr Ser
    50                  55

<210> 637
<211> 58
<212> PRT
<213> Homo sapiens

<400> 637
Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys
 1               5                  10                  15
Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn Met Leu
            20                  25                  30
Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly Pro Asn
        35                  40                  45
Met Gly Gln Pro Gln Pro Gly Met Thr Ser
    50                  55

<210> 638
<211> 58
<212> PRT
<213> Homo sapiens

<400> 638
Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys
 1               5                  10                  15
Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn Met Leu
            20                  25                  30
Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly Pro Asn
        35                  40                  45
Met Gly Gln Pro Gln Pro Gly Met Thr Ser
    50                  55

<210> 639
<211> 58
<212> PRT
<213> Homo sapiens

<400> 639
Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys
 1               5                  10                  15
Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn Met Leu
            20                  25                  30
Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly Pro Asn
        35                  40                  45
Met Gly Gln Pro Gln Pro Gly Met Thr Ser
    50                  55

<210> 640
<211> 58
<212> PRT
<213> Homo sapiens

<400> 640
Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys
 1               5                  10                  15
Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn Met Leu
            20                  25                  30
Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly Pro Asn
        35                  40                  45
Met Gly Gln Pro Gln Pro Gly Met Thr Ser
    50                  55

<210> 641
<211> 2414
<212> PRT
<213> Homo sapiens

<400> 641
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro
 1               5                  10                  15
Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp
            20                  25                  30
Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile
        35                  40                  45
Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu
    50                  55                  60
Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln
65                  70                  75                  80
Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly
                85                  90                  95
Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser
            100                 105                 110
Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln
        115                 120                 125
Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn
    130                 135                 140
Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln
145                 150                 155                 160
Pro Ala Met Gly Met Asn Thr Gly Thr Asn Ala Gly Met Asn Pro Gly
                165                 170                 175
Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met
            180                 185                 190
Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asp Met Gln Tyr Pro
        195                 200                 205
Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln
    210                 215                 220
Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln
225                 230                 235                 240
Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro
                245                 250                 255
Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu
            260                 265                 270
Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala
        275                 280                 285
Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln
    290                 295                 300
Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala
305                 310                 315                 320
Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys
                325                 330                 335
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
            340                 345                 350
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His
        355                 360                 365
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser
    370                 375                 380
Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
385                 390                 395                 400
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
                405                 410                 415
Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly
            420                 425                 430
Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln
        435                 440                 445
Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile
    450                 455                 460
Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met
465                 470                 475                 480
Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro
                485                 490                 495
Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser
            500                 505                 510
Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu
        515                 520                 525
Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met
    530                 535                 540
Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala
545                 550                 555                 560
Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr
                565                 570                 575
Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe
            580                 585                 590
Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu
        595                 600                 605
Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn
    610                 615                 620
Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile
625                 630                 635                 640
Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn
                645                 650                 655
Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly
            660                 665                 670
Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu
        675                 680                 685
Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro
    690                 695                 700
Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met
705                 710                 715                 720
Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His
                725                 730                 735
Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly
            740                 745                 750
Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr
        755                 760                 765
Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro
    770                 775                 780
Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser
785                 790                 795                 800
Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His
                805                 810                 815
Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro
            820                 825                 830
Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser
        835                 840                 845
Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro
    850                 855                 860
Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro
865                 870                 875                 880
Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln
                885                 890                 895
Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln
            900                 905                 910
Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Asn
        915                 920                 925
Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala
    930                 935                 940
Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr
945                 950                 955                 960
Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val
                965                 970                 975
Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr
            980                 985                 990
Gln Pro Glu Asp Ile Ser Glu Ser Lys Val Glu Asp Cys Lys Met Glu
        995                 1000                1005
Ser Thr Glu Thr Glu Glu Arg Ser Thr Glu Leu Lys Thr Glu Ile Lys
    1010                1015                1020
Glu Glu Glu Asp Gln Pro Ser Thr Ser Ala Thr Gln Ser Ser Pro Ala
1025                1030                1035                1040
Pro Gly Gln Ser Lys Lys Lys Ile Phe Lys Pro Glu Glu Leu Arg Gln
                1045                1050                1055
Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp Pro Glu Ser
            1060                1065                1070
Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly Ile Pro Asp
        1075                1080                1085
Tyr Phe Asp Ile Val Lys Ser Pro Met Asp Leu Ser Thr Ile Lys Arg
    1090                1095                1100
Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr Val Asp Asp
1105                1110                1115                1120
Ile Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg Lys Thr Ser
                1125                1130                1135
Arg Val Tyr Lys Tyr Cys Ser Lys Leu Ser Glu Val Phe Glu Gln Glu
            1140                1145                1150
Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly Arg Lys Leu
        1155                1160                1165
Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln Leu Cys Thr
    1170                1175                1180
Ile Pro Arg Asp Ala Thr Tyr Tyr Ser Tyr Gln Asn Arg Tyr His Phe
1185                1190                1195                1200
Cys Glu Lys Cys Phe Asn Glu Ile Gln Gly Glu Ser Val Ser Leu Gly
                1205                1210                1215
Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Asn Lys Glu Gln Phe Ser
            1220                1225                1230
Lys Arg Lys Asn Asp Thr Leu Asp Pro Glu Leu Phe Val Glu Cys Thr
        1235                1240                1245
Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu His His Glu Ile
    1250                1255                1260
Ile Trp Pro Ala Gly Phe Val Cys Asp Gly Cys Leu Lys Lys Ser Ala
1265                1270                1275                1280
Arg Thr Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Pro Ser Thr
                1285                1290                1295
Arg Leu Gly Thr Phe Leu Glu Asn Arg Val Asn Asp Phe Leu Arg Arg
            1300                1305                1310
Gln Asn His Pro Glu Ser Gly Glu Val Thr Val Arg Val Val His Ala
        1315                1320                1325
Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys Ala Arg Phe Val
    1330                1335                1340
Asp Ser Gly Glu Met Ala Glu Ser Phe Pro Tyr Arg Thr Lys Ala Leu
1345                1350                1355                1360
Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Leu Cys Phe Phe Gly Met
                1365                1370                1375
His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Gln Arg Arg
            1380                1385                1390
Val Tyr Ile Ser Tyr Leu Asp Ser Val His Phe Phe Arg Pro Lys Cys
        1395                1400                1405
Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly Tyr Leu Glu Tyr
    1410                1415                1420
Val Lys Lys Leu Gly Tyr Thr Thr Gly His Ile Trp Ala Cys Pro Pro
1425                1430                1435                1440
Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro Pro Asp Gln Lys
                1445                1450                1455
Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys Lys Met Leu Asp
            1460                1465                1470
Lys Ala Val Ser Glu Arg Ile Val His Asp Tyr Lys Asp Ile Phe Lys
        1475                1480                1485
Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu Leu Pro Tyr Phe
    1490                1495                1500
Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser Ile Lys Glu Leu
1505                1510                1515                1520
Glu Gln Glu Glu Glu Glu Arg Lys Arg Glu Glu Asn Thr Ser Asn Glu
                1525                1530                1535
Ser Thr Asp Val Thr Lys Gly Asp Ser Lys Asn Ala Lys Lys Lys Asn
            1540                1545                1550
Asn Lys Lys Thr Ser Lys Asn Lys Ser Ser Leu Ser Arg Gly Asn Lys
        1555                1560                1565
Lys Lys Pro Gly Met Pro Asn Val Ser Asn Asp Leu Ser Gln Lys Leu
    1570                1575                1580
Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe Phe Val Ile Arg Leu
1585                1590                1595                1600
Ile Ala Gly Pro Ala Ala Asn Ser Leu Pro Pro Ile Val Asp Pro Asp
                1605                1610                1615
Pro Leu Ile Pro Cys Asp Leu Met Asp Gly Arg Asp Ala Phe Leu Thr
            1620                1625                1630
Leu Ala Arg Asp Lys His Leu Glu Phe Ser Ser Leu Arg Arg Ala Gln
        1635                1640                1645
Trp Ser Thr Met Cys Met Leu Val Glu Leu His Thr Gln Ser Gln Asp
    1650                1655                1660
Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His His Val Glu Thr Arg
1665                1670                1675                1680
Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu Cys Ile Thr Cys Tyr
                1685                1690                1695
Asn Thr Lys Asn His Asp His Lys Met Glu Lys Leu Gly Leu Gly Leu
            1700                1705                1710
Asp Asp Glu Ser Asn Asn Gln Gln Ala Ala Ala Thr Gln Ser Pro Gly
        1715                1720                1725
Asp Ser Arg Arg Leu Ser Ile Gln Arg Cys Ile Gln Ser Leu Val His
    1730                1735                1740
Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu Pro Ser Cys Gln Lys
1745                1750                1755                1760
Met Lys Arg Val Val Gln His Thr Lys Gly Cys Lys Arg Lys Thr Asn
                1765                1770                1775
Gly Gly Cys Pro Ile Cys Lys Gln Leu Ile Ala Leu Cys Cys Tyr His
            1780                1785                1790
Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val Pro Phe Cys Leu Asn
        1795                1800                1805
Ile Lys Gln Lys Leu Arg Gln Gln Gln Leu Gln His Arg Leu Gln Gln
    1810                1815                1820
Ala Gln Met Leu Arg Arg Arg Met Ala Ser Met Gln Arg Thr Gly Val
1825                1830                1835                1840
Val Gly Gln Gln Gln Gly Leu Pro Ser Pro Thr Pro Ala Thr Pro Thr
                1845                1850                1855
Thr Pro Thr Gly Gln Gln Pro Thr Thr Pro Gln Thr Pro Gln Pro Thr
            1860                1865                1870
Ser Gln Pro Gln Pro Thr Pro Pro Asn Ser Met Pro Pro Tyr Leu Pro
        1875                1880                1885
Arg Thr Gln Ala Ala Gly Pro Val Ser Gln Gly Lys Ala Ala Gly Gln
    1890                1895                1900
Val Thr Pro Pro Thr Pro Pro Gln Thr Ala Gln Pro Pro Leu Pro Gly
1905                1910                1915                1920
Pro Pro Pro Thr Ala Val Glu Met Ala Met Gln Ile Gln Arg Ala Ala
                1925                1930                1935
Glu Thr Gln Arg Gln Met Ala His Val Gln Ile Phe Gln Arg Pro Ile
            1940                1945                1950
Gln His Gln Met Pro Pro Met Thr Pro Met Ala Pro Met Gly Met Asn
        1955                1960                1965
Pro Pro Pro Met Thr Arg Gly Pro Ser Gly His Leu Glu Pro Gly Met
    1970                1975                1980
Gly Pro Thr Gly Met Gln Gln Gln Pro Pro Trp Ser Gln Gly Gly Leu
1985                1990                1995                2000
Pro Gln Pro Gln Gln Leu Gln Ser Gly Met Pro Arg Pro Ala Met Met
                2005                2010                2015
Ser Val Ala Gln His Gly Gln Pro Leu Asn Met Ala Pro Gln Pro Gly
            2020                2025                2030
Leu Gly Gln Val Gly Ile Ser Pro Leu Lys Pro Gly Thr Val Ser Gln
        2035                2040                2045
Gln Ala Leu Gln Asn Leu Leu Arg Thr Leu Arg Ser Pro Ser Ser Pro
    2050                2055                2060
Leu Gln Gln Gln Gln Val Leu Ser Ile Leu His Ala Asn Pro Gln Leu
2065                2070                2075                2080
Leu Ala Ala Phe Ile Lys Gln Arg Ala Ala Lys Tyr Ala Asn Ser Asn
                2085                2090                2095
Pro Gln Pro Ile Pro Gly Gln Pro Gly Met Pro Gln Gly Gln Pro Gly
            2100                2105                2110
Leu Gln Pro Pro Thr Met Pro Gly Gln Gln Gly Val His Ser Asn Pro
        2115                2120                2125
Ala Met Gln Asn Met Asn Pro Met Gln Ala Gly Val Gln Arg Ala Gly
    2130                2135                2140
Leu Pro Gln Gln Gln Pro Gln Gln Gln Leu Gln Pro Pro Met Gly Gly
2145                2150                2155                2160
Met Ser Pro Gln Ala Gln Gln Met Asn Met Asn His Asn Thr Met Pro
                2165                2170                2175
Ser Gln Phe Arg Asp Ile Leu Arg Arg Gln Gln Met Met Gln Gln Gln
            2180                2185                2190
Gln Gln Gln Gly Ala Gly Pro Gly Ile Gly Pro Gly Met Ala Asn His
        2195                2200                2205
Asn Gln Phe Gln Gln Pro Gln Gly Val Gly Tyr Pro Pro Gln Pro Gln
    2210                2215                2220
Gln Arg Met Gln His His Met Gln Gln Met Gln Gln Gly Asn Met Gly
2225                2230                2235                2240
Gln Ile Gly Gln Leu Pro Gln Ala Leu Gly Ala Glu Ala Gly Ala Ser
                2245                2250                2255
Leu Gln Ala Tyr Gln Gln Arg Leu Leu Gln Gln Gln Met Gly Ser Pro
            2260                2265                2270
Val Gln Pro Asn Pro Met Ser Pro Gln Gln His Met Leu Pro Asn Gln
        2275                2280                2285
Ala Gln Ser Pro His Leu Gln Gly Gln Gln Ile Pro Asn Ser Leu Ser
    2290                2295                2300
Asn Gln Val Arg Ser Pro Gln Pro Val Pro Ser Pro Arg Pro Gln Ser
2305                2310                2315                2320
Gln Pro Pro His Ser Ser Pro Ser Pro Arg Met Gln Pro Gln Pro Ser
                2325                2330                2335
Pro His His Val Ser Pro Gln Thr Ser Ser Pro His Pro Gly Leu Val
            2340                2345                2350
Ala Ala Gln Ala Asn Pro Met Glu Gln Gly His Phe Ala Ser Pro Asp
        2355                2360                2365
Gln Asn Ser Met Leu Ser Gln Leu Ala Ser Asn Pro Gly Met Ala Asn
    2370                2375                2380
Leu His Gly Ala Ser Ala Thr Asp Leu Gly Leu Ser Thr Asp Asn Ser
2385                2390                2395                2400
Asp Leu Asn Ser Asn Leu Ser Gln Ser Thr Leu Asp Ile His
                2405                2410

<210> 642
<211> 2414
<212> PRT
<213> Homo sapiens

<400> 642
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro
 1               5                  10                  15
Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp
            20                  25                  30
Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile
        35                  40                  45
Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu
    50                  55                  60
Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln
65                  70                  75                  80
Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly
                85                  90                  95
Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser
            100                 105                 110
Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln
        115                 120                 125
Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn
    130                 135                 140
Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln
145                 150                 155                 160
Pro Ala Met Gly Met Asn Thr Gly Thr Asn Ala Gly Met Asn Pro Gly
                165                 170                 175
Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met
            180                 185                 190
Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asp Met Gln Tyr Pro
        195                 200                 205
Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln
    210                 215                 220
Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln
225                 230                 235                 240
Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro
                245                 250                 255
Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu
            260                 265                 270
Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala
        275                 280                 285
Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln
    290                 295                 300
Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala
305                 310                 315                 320
Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys
                325                 330                 335
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
            340                 345                 350
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His
        355                 360                 365
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser
    370                 375                 380
Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
385                 390                 395                 400
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
                405                 410                 415
Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly
            420                 425                 430
Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln
        435                 440                 445
Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile
    450                 455                 460
Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met
465                 470                 475                 480
Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro
                485                 490                 495
Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser
            500                 505                 510
Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu
        515                 520                 525
Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met
    530                 535                 540
Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala
545                 550                 555                 560
Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr
                565                 570                 575
Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe
            580                 585                 590
Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu
        595                 600                 605
Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn
    610                 615                 620
Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile
625                 630                 635                 640
Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn
                645                 650                 655
Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly
            660                 665                 670
Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu
        675                 680                 685
Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro
    690                 695                 700
Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met
705                 710                 715                 720
Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His
                725                 730                 735
Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly
            740                 745                 750
Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr
        755                 760                 765
Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro
    770                 775                 780
Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser
785                 790                 795                 800
Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His
                805                 810                 815
Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro
            820                 825                 830
Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser
        835                 840                 845
Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro
    850                 855                 860
Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro
865                 870                 875                 880
Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln
                885                 890                 895
Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln
            900                 905                 910
Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Asn
        915                 920                 925
Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala
    930                 935                 940
Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr
945                 950                 955                 960
Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val
                965                 970                 975
Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr
            980                 985                 990
Gln Pro Glu Asp Ile Ser Glu Ser Lys Val Glu Asp Cys Lys Met Glu
        995                 1000                1005
Ser Thr Glu Thr Glu Glu Arg Ser Thr Glu Leu Lys Thr Glu Ile Lys
    1010                1015                1020
Glu Glu Glu Asp Gln Pro Ser Thr Ser Ala Thr Gln Ser Ser Pro Ala
1025                1030                1035                1040
Pro Gly Gln Ser Lys Lys Lys Ile Phe Lys Pro Glu Glu Leu Arg Gln
                1045                1050                1055
Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp Pro Glu Ser
            1060                1065                1070
Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly Ile Pro Asp
        1075                1080                1085
Tyr Phe Asp Ile Val Lys Ser Pro Met Asp Leu Ser Thr Ile Lys Arg
    1090                1095                1100
Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr Val Asp Asp
1105                1110                1115                1120
Ile Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg Lys Thr Ser
                1125                1130                1135
Arg Val Tyr Lys Tyr Cys Ser Lys Leu Ser Glu Val Phe Glu Gln Glu
            1140                1145                1150
Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly Arg Lys Leu
        1155                1160                1165
Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln Leu Cys Thr
    1170                1175                1180
Ile Pro Arg Asp Ala Thr Tyr Tyr Ser Tyr Gln Asn Arg Tyr His Phe
1185                1190                1195                1200
Cys Glu Lys Cys Phe Asn Glu Ile Gln Gly Glu Ser Val Ser Leu Gly
                1205                1210                1215
Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Asn Lys Glu Gln Phe Ser
            1220                1225                1230
Lys Arg Lys Asn Asp Thr Leu Asp Pro Glu Leu Phe Val Glu Cys Thr
        1235                1240                1245
Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu His His Glu Ile
    1250                1255                1260
Ile Trp Pro Ala Gly Phe Val Cys Asp Gly Cys Leu Lys Lys Ser Ala
1265                1270                1275                1280
Arg Thr Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Pro Ser Thr
                1285                1290                1295
Arg Leu Gly Thr Phe Leu Glu Asn Arg Val Asn Asp Phe Leu Arg Arg
            1300                1305                1310
Gln Asn His Pro Glu Ser Gly Glu Val Thr Val Arg Val Val His Ala
        1315                1320                1325
Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys Ala Arg Phe Val
    1330                1335                1340
Asp Ser Gly Glu Met Ala Glu Ser Phe Pro Tyr Arg Thr Lys Ala Leu
1345                1350                1355                1360
Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Leu Cys Phe Phe Gly Met
                1365                1370                1375
His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Gln Arg Arg
            1380                1385                1390
Val Tyr Ile Ser Tyr Leu Asp Ser Val His Phe Phe Arg Pro Lys Cys
        1395                1400                1405
Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly Tyr Leu Glu Tyr
    1410                1415                1420
Val Lys Lys Leu Gly Tyr Thr Thr Gly His Ile Trp Ala Cys Pro Pro
1425                1430                1435                1440
Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro Pro Asp Gln Lys
                1445                1450                1455
Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys Lys Met Leu Asp
            1460                1465                1470
Lys Ala Val Ser Glu Arg Ile Val His Asp Tyr Lys Asp Ile Phe Lys
        1475                1480                1485
Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu Leu Pro Tyr Phe
    1490                1495                1500
Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser Ile Lys Glu Leu
1505                1510                1515                1520
Glu Gln Glu Glu Glu Glu Arg Lys Arg Glu Glu Asn Thr Ser Asn Glu
                1525                1530                1535
Ser Thr Asp Val Thr Lys Gly Asp Ser Lys Asn Ala Lys Lys Lys Asn
            1540                1545                1550
Asn Lys Lys Thr Ser Lys Asn Lys Ser Ser Leu Ser Arg Gly Asn Lys
        1555                1560                1565
Lys Lys Pro Gly Met Pro Asn Val Ser Asn Asp Leu Ser Gln Lys Leu
    1570                1575                1580
Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe Phe Val Ile Arg Leu
1585                1590                1595                1600
Ile Ala Gly Pro Ala Ala Asn Ser Leu Pro Pro Ile Val Asp Pro Asp
                1605                1610                1615
Pro Leu Ile Pro Cys Asp Leu Met Asp Gly Arg Asp Ala Phe Leu Thr
            1620                1625                1630
Leu Ala Arg Asp Lys His Leu Glu Phe Ser Ser Leu Arg Arg Ala Gln
        1635                1640                1645
Trp Ser Thr Met Cys Met Leu Val Glu Leu His Thr Gln Ser Gln Asp
    1650                1655                1660
Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His His Val Glu Thr Arg
1665                1670                1675                1680
Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu Cys Ile Thr Cys Tyr
                1685                1690                1695
Asn Thr Lys Asn His Asp His Lys Met Glu Lys Leu Gly Leu Gly Leu
            1700                1705                1710
Asp Asp Glu Ser Asn Asn Gln Gln Ala Ala Ala Thr Gln Ser Pro Gly
        1715                1720                1725
Asp Ser Arg Arg Leu Ser Ile Gln Arg Cys Ile Gln Ser Leu Val His
    1730                1735                1740
Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu Pro Ser Cys Gln Lys
1745                1750                1755                1760
Met Lys Arg Val Val Gln His Thr Lys Gly Cys Lys Arg Lys Thr Asn
                1765                1770                1775
Gly Gly Cys Pro Ile Cys Lys Gln Leu Ile Ala Leu Cys Cys Tyr His
            1780                1785                1790
Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val Pro Phe Cys Leu Asn
        1795                1800                1805
Ile Lys Gln Lys Leu Arg Gln Gln Gln Leu Gln His Arg Leu Gln Gln
    1810                1815                1820
Ala Gln Met Leu Arg Arg Arg Met Ala Ser Met Gln Arg Thr Gly Val
1825                1830                1835                1840
Val Gly Gln Gln Gln Gly Leu Pro Ser Pro Thr Pro Ala Thr Pro Thr
                1845                1850                1855
Thr Pro Thr Gly Gln Gln Pro Thr Thr Pro Gln Thr Pro Gln Pro Thr
            1860                1865                1870
Ser Gln Pro Gln Pro Thr Pro Pro Asn Ser Met Pro Pro Tyr Leu Pro
        1875                1880                1885
Arg Thr Gln Ala Ala Gly Pro Val Ser Gln Gly Lys Ala Ala Gly Gln
    1890                1895                1900
Val Thr Pro Pro Thr Pro Pro Gln Thr Ala Gln Pro Pro Leu Pro Gly
1905                1910                1915                1920
Pro Pro Pro Thr Ala Val Glu Met Ala Met Gln Ile Gln Arg Ala Ala
                1925                1930                1935
Glu Thr Gln Arg Gln Met Ala His Val Gln Ile Phe Gln Arg Pro Ile
            1940                1945                1950
Gln His Gln Met Pro Pro Met Thr Pro Met Ala Pro Met Gly Met Asn
        1955                1960                1965
Pro Pro Pro Met Thr Arg Gly Pro Ser Gly His Leu Glu Pro Gly Met
    1970                1975                1980
Gly Pro Thr Gly Met Gln Gln Gln Pro Pro Trp Ser Gln Gly Gly Leu
1985                1990                1995                2000
Pro Gln Pro Gln Gln Leu Gln Ser Gly Met Pro Arg Pro Ala Met Met
                2005                2010                2015
Ser Val Ala Gln His Gly Gln Pro Leu Asn Met Ala Pro Gln Pro Gly
            2020                2025                2030
Leu Gly Gln Val Gly Ile Ser Pro Leu Lys Pro Gly Thr Val Ser Gln
        2035                2040                2045
Gln Ala Leu Gln Asn Leu Leu Arg Thr Leu Arg Ser Pro Ser Ser Pro
    2050                2055                2060
Leu Gln Gln Gln Gln Val Leu Ser Ile Leu His Ala Asn Pro Gln Leu
2065                2070                2075                2080
Leu Ala Ala Phe Ile Lys Gln Arg Ala Ala Lys Tyr Ala Asn Ser Asn
                2085                2090                2095
Pro Gln Pro Ile Pro Gly Gln Pro Gly Met Pro Gln Gly Gln Pro Gly
            2100                2105                2110
Leu Gln Pro Pro Thr Met Pro Gly Gln Gln Gly Val His Ser Asn Pro
        2115                2120                2125
Ala Met Gln Asn Met Asn Pro Met Gln Ala Gly Val Gln Arg Ala Gly
    2130                2135                2140
Leu Pro Gln Gln Gln Pro Gln Gln Gln Leu Gln Pro Pro Met Gly Gly
2145                2150                2155                2160
Met Ser Pro Gln Ala Gln Gln Met Asn Met Asn His Asn Thr Met Pro
                2165                2170                2175
Ser Gln Phe Arg Asp Ile Leu Arg Arg Gln Gln Met Met Gln Gln Gln
            2180                2185                2190
Gln Gln Gln Gly Ala Gly Pro Gly Ile Gly Pro Gly Met Ala Asn His
        2195                2200                2205
Asn Gln Phe Gln Gln Pro Gln Gly Val Gly Tyr Pro Pro Gln Pro Gln
    2210                2215                2220
Gln Arg Met Gln His His Met Gln Gln Met Gln Gln Gly Asn Met Gly
2225                2230                2235                2240
Gln Ile Gly Gln Leu Pro Gln Ala Leu Gly Ala Glu Ala Gly Ala Ser
                2245                2250                2255
Leu Gln Ala Tyr Gln Gln Arg Leu Leu Gln Gln Gln Met Gly Ser Pro
            2260                2265                2270
Val Gln Pro Asn Pro Met Ser Pro Gln Gln His Met Leu Pro Asn Gln
        2275                2280                2285
Ala Gln Ser Pro His Leu Gln Gly Gln Gln Ile Pro Asn Ser Leu Ser
    2290                2295                2300
Asn Gln Val Arg Ser Pro Gln Pro Val Pro Ser Pro Arg Pro Gln Ser
2305                2310                2315                2320
Gln Pro Pro His Ser Ser Pro Ser Pro Arg Met Gln Pro Gln Pro Ser
                2325                2330                2335
Pro His His Val Ser Pro Gln Thr Ser Ser Pro His Pro Gly Leu Val
            2340                2345                2350
Ala Ala Gln Ala Asn Pro Met Glu Gln Gly His Phe Ala Ser Pro Asp
        2355                2360                2365
Gln Asn Ser Met Leu Ser Gln Leu Ala Ser Asn Pro Gly Met Ala Asn
    2370                2375                2380
Leu His Gly Ala Ser Ala Thr Asp Leu Gly Leu Ser Thr Asp Asn Ser
2385                2390                2395                2400
Asp Leu Asn Ser Asn Leu Ser Gln Ser Thr Leu Asp Ile His
                2405                2410

<210> 643
<211> 2441
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(2441)
<223> Xaa = Any Amino Acid

<400> 643
Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys
 1               5                  10                  15
Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Asn Thr Asp Phe Gly Ser
            20                  25                  30
Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly
        35                  40                  45
Glu Leu Ser Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala Ser
    50                  55                  60
Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser Ser
65                  70                  75                  80
Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln Gln
                85                  90                  95
Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Thr Asn Met Ala
            100                 105                 110
Ser Leu Gly Ala Met Gly Lys Ser Pro Leu Asn Gln Gly Asp Ser Ser
        115                 120                 125
Thr Pro Asn Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr Pro
    130                 135                 140
Pro Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly Leu
145                 150                 155                 160
Val Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys Met
                165                 170                 175
Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn Ser
            180                 185                 190
Gly His Ser Leu Met Asn Gln Ala Gln Gln Gly Gln Ala Gln Val Met
        195                 200                 205
Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met Pro
    210                 215                 220
Tyr Pro Ala Pro Ala Met Gln Gly Ala Thr Ser Ser Val Leu Ala Glu
225                 230                 235                 240
Thr Leu Thr Gln Val Ser Pro Gln Met Ala Gly His Ala Gly Leu Asn
                245                 250                 255
Thr Ala Gln Ala Gly Gly Met Thr Lys Met Gly Met Thr Gly Thr Thr
            260                 265                 270
Ser Pro Phe Gly Gln Pro Phe Ser Gln Thr Gly Gly Gln Gln Met Gly
        275                 280                 285
Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val Asn
    290                 295                 300
Ser Leu Pro Ala Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr Thr
305                 310                 315                 320
Val Pro Asn Met Ser Gln Leu Gln Thr Ser Val Gly Ile Val Pro Thr
                325                 330                 335
Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys Leu
            340                 345                 350
Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln Arg
        355                 360                 365
Arg Glu Gln Ala Asn Gly Glu Val Xaa Ala Cys Ser Leu Pro His Cys
    370                 375                 380
Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala Pro
385                 390                 395                 400
Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile Ser
                405                 410                 415
His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro Leu
            420                 425                 430
Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser Pro
        435                 440                 445
Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Ala Gly Gln Gln
    450                 455                 460
Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser Met
465                 470                 475                 480
Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro Gln
                485                 490                 495
Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro Pro
            500                 505                 510
Ala His Gln Gln Met Arg Thr Leu Asn Ala Leu Gly Asn Asn Pro Met
        515                 520                 525
Ser Val Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn Leu
    530                 535                 540
Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro Leu
545                 550                 555                 560
Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Ser Leu Ser Thr Ile
                565                 570                 575
Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp His
            580                 585                 590
Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu Val
        595                 600                 605
Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg
    610                 615                 620
Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met Tyr
625                 630                 635                 640
Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu Lys
                645                 650                 655
Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu
            660                 665                 670
His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Ser Gly
        675                 680                 685
Ala Gln Pro Pro Val Ile Pro Pro Ala Gln Ser Val Arg Pro Pro Asn
    690                 695                 700
Gly Pro Leu Pro Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly Met
705                 710                 715                 720
Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln Ala
                725                 730                 735
Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln Met
            740                 745                 750
Asn Ser Met Ala Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg Met
        755                 760                 765
Pro Gln Pro Pro Asn Met Met Gly Thr His Ala Asn Asn Ile Met Ala
    770                 775                 780
Gln Ala Pro Thr Gln Asn Gln Phe Leu Pro Gln Asn Gln Phe Pro Ser
785                 790                 795                 800
Ser Ser Gly Ala Met Ser Val Asn Ser Val Gly Met Gly Gln Pro Ala
                805                 810                 815
Ala Gln Ala Gly Val Ser Gln Gly Gln Glu Pro Gly Ala Ala Leu Pro
            820                 825                 830
Asn Pro Leu Asn Met Leu Ala Pro Gln Ala Ser Gln Leu Pro Cys Pro
        835                 840                 845
Pro Val Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr
    850                 855                 860
Ala Ala Gly Met Pro Ser Leu Gln His Pro Thr Ala Pro Gly Met Thr
865                 870                 875                 880
Pro Pro Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser
                885                 890                 895
Gly Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Ala Gln
            900                 905                 910
Thr Gln Ser Thr Pro Thr Val His Ala Ala Ala Gln Ala Gln Val Thr
        915                 920                 925
Pro Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln
    930                 935                 940
Ser Ser Gln Gln Gln Pro Thr Pro Val His Thr Gln Pro Pro Gly Thr
945                 950                 955                 960
Pro Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro
                965                 970                 975
Ser Thr Val Thr Ser Ala Glu Thr Ser Ser Gln Gln Pro Gly Pro Asp
            980                 985                 990
Val Pro Met Leu Glu Met Lys Thr Glu Val Gln Thr Asp Asp Ala Glu
        995                 1000                1005
Pro Glu Pro Thr Glu Ser Lys Gly Glu Pro Arg Ser Glu Met Met Glu
    1010                1015                1020
Glu Asp Leu Gln Gly Ser Ser Gln Val Lys Glu Glu Thr Asp Thr Thr
1025                1030                1035                1040
Glu Gln Lys Ser Glu Pro Met Glu Val Glu Glu Lys Lys Pro Glu Val
                1045                1050                1055
Lys Val Glu Ala Lys Glu Glu Glu Glu Asn Ser Ser Asn Asp Thr Ala
            1060                1065                1070
Ser Gln Ser Thr Ser Pro Ser Gln Pro Arg Lys Lys Ile Phe Lys Pro
        1075                1080                1085
Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg
    1090                1095                1100
Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu
1105                1110                1115                1120
Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn Pro Met Asp Leu
                1125                1130                1135
Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp
            1140                1145                1150
Gln Tyr Val Asp Asp Val Arg Leu Met Phe Asn Asn Ala Trp Leu Tyr
        1155                1160                1165
Asn Arg Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser Lys Leu Ala Glu
    1170                1175                1180
Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys
1185                1190                1195                1200
Cys Gly Arg Lys Tyr Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly
                1205                1210                1215
Lys Gln Leu Cys Thr Ile Pro Arg Asp Ala Ala Tyr Tyr Ser Tyr Gln
            1220                1225                1230
Asn Arg Tyr His Phe Cys Gly Lys Cys Phe Thr Glu Ile Gln Gly Glu
        1235                1240                1245
Asn Val Thr Leu Gly Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Ser
    1250                1255                1260
Lys Asp Gln Phe Glu Lys Lys Lys Asn Asp Thr Leu Asp Pro Glu Pro
1265                1270                1275                1280
Phe Val Asp Cys Lys Glu Cys Gly Arg Lys Met His Gln Ile Cys Val
                1285                1290                1295
Leu His Tyr Asp Ile Ile Trp Pro Ser Gly Phe Val Cys Asp Asn Cys
            1300                1305                1310
Leu Lys Lys Thr Gly Arg Pro Arg Lys Glu Asn Lys Phe Ser Ala Lys
        1315                1320                1325
Arg Leu Gln Thr Thr Arg Leu Gly Asn His Leu Glu Asp Arg Val Asn
    1330                1335                1340
Lys Phe Leu Arg Arg Gln Asn His Pro Glu Ala Gly Glu Val Phe Val
1345                1350                1355                1360
Arg Val Val Ala Ser Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met
                1365                1370                1375
Lys Ser Arg Phe Val Asp Ser Gly Glu Met Ser Glu Ser Phe Pro Tyr
            1380                1385                1390
Arg Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Val
        1395                1400                1405
Cys Phe Phe Gly Met His Val Gln Asp Thr Ala Leu Ile Ala Pro His
    1410                1415                1420
Gln Ile Gln Gly Cys Val Tyr Ile Ser Tyr Leu Asp Ser Ile His Phe
1425                1430                1435                1440
Phe Arg Pro Arg Cys Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile
                1445                1450                1455
Gly Tyr Leu Glu Tyr Val Lys Lys Leu Val Tyr Val Thr Ala His Ile
            1460                1465                1470
Trp Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His
        1475                1480                1485
Pro Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr
    1490                1495                1500
Lys Lys Met Leu Asp Lys Ala Phe Ala Glu Arg Ile Ile Asn Asp Tyr
1505                1510                1515                1520
Lys Asp Ile Phe Thr Gln Ala Asn Glu Asp Arg Leu Thr Ser Ala Lys
                1525                1530                1535
Glu Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu
            1540                1545                1550
Ser Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg Lys Lys Glu Glu
        1555                1560                1565
Ser Thr Ala Ala Ser Glu Thr Pro Glu Gly Ser Gln Gly Asp Ser Lys
    1570                1575                1580
Asn Ala Lys Lys Lys Asn Asn Lys Lys Thr Asn Lys Asn Lys Ser Ser
1585                1590                1595                1600
Ile Ser Arg Ala Asn Lys Lys Lys Pro Ser Met Pro Asn Val Ser Asn
                1605                1610                1615
Asp Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His Lys Glu Val
            1620                1625                1630
Phe Phe Val Ile His Leu His Ala Gly Pro Val Ile Ser Thr Gln Pro
        1635                1640                1645
Pro Ile Val Asp Pro Asp Pro Leu Leu Ser Cys Asp Leu Met Asp Gly
    1650                1655                1660
Arg Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Trp Glu Phe Ser
1665                1670                1675                1680
Ser Leu Arg Arg Ser Lys Trp Ser Thr Leu Cys Met Leu Val Glu Leu
                1685                1690                1695
His Thr Gln Gly Gln Asp Arg Phe Val Tyr Thr Cys Asn Glu Cys Ile
            1700                1705                1710
His His Val Glu Thr Arg Trp His Cys Thr Val Cys Glu Asp Tyr Asp
        1715                1720                1725
Leu Cys Ile Asn Cys Tyr Asn Thr Lys Ser His Thr His Lys Met Val
    1730                1735                1740
Lys Trp Gly Leu Gly Leu Asp Asp Glu Gly Ser Ser Gln Gly Glu Pro
1745                1750                1755                1760
Gln Ser Lys Ser Pro Gln Glu Ser Arg Arg Leu Ser Ile Gln Arg Cys
                1765                1770                1775
Ile Gln Ser Leu Val His Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser
            1780                1785                1790
Leu Pro Ser Cys Gln Lys Met Lys Arg Val Val Gln His Thr Lys Gly
        1795                1800                1805
Cys Lys Arg Lys Thr Asn Gly Gly Cys Pro Val Cys Lys Gln Leu Ile
    1810                1815                1820
Ala Leu Cys Cys Tyr His Ala Lys His Cys Gln Glu Asn Lys Cys Pro
1825                1830                1835                1840
Val Pro Phe Cys Leu Asn Ile Lys His Asn Val Arg Gln Gln Gln Ile
                1845                1850                1855
Gln His Cys Leu Gln Gln Ala Gln Leu Met Arg Arg Arg Met Ala Thr
            1860                1865                1870
Met Asn Thr Arg Asn Val Pro Gln Gln Ser Leu Pro Ser Pro Thr Ser
        1875                1880                1885
Ala Pro Pro Gly Thr Pro Thr Gln Gln Pro Ser Thr Pro Gln Thr Pro
    1890                1895                1900
Gln Pro Pro Ala Gln Pro Gln Pro Ser Pro Val Asn Met Ser Pro Ala
1905                1910                1915                1920
Gly Phe Pro Asn Val Ala Arg Thr Gln Pro Pro Thr Ile Val Ser Ala
                1925                1930                1935
Gly Lys Pro Thr Asn Gln Val Pro Ala Pro Pro Pro Pro Ala Gln Pro
            1940                1945                1950
Pro Pro Ala Ala Val Glu Ala Ala Arg Gln Ile Glu Arg Glu Ala Gln
        1955                1960                1965
Gln Gln Gln His Leu Tyr Arg Ala Asn Ile Asn Asn Gly Met Pro Pro
    1970                1975                1980
Gly Arg Asp Gly Met Gly Thr Pro Gly Ser Gln Met Thr Pro Val Gly
1985                1990                1995                2000
Leu Asn Val Pro Arg Pro Asn Gln Val Ser Gly Pro Val Met Ser Ser
                2005                2010                2015
Met Pro Pro Gly Gln Trp Gln Gln Ala Pro Ile Pro Gln Gln Gln Pro
            2020                2025                2030
Met Pro Gly Met Pro Arg Pro Val Met Ser Met Gln Ala Gln Ala Ala
        2035                2040                2045
Val Ala Gly Pro Arg Met Pro Asn Val Gln Pro Asn Arg Ser Ile Ser
    2050                2055                2060
Pro Ser Ala Leu Gln Asp Leu Leu Arg Thr Leu Lys Ser Pro Ser Ser
2065                2070                2075                2080
Pro Gln Gln Gln Gln Gln Val Leu Asn Ile Leu Lys Ser Asn Pro Gln
                2085                2090                2095
Leu Met Ala Ala Phe Ile Lys Gln Arg Thr Ala Lys Tyr Val Ala Asn
            2100                2105                2110
Gln Pro Gly Met Gln Pro Gln Pro Gly Leu Gln Ser Gln Pro Gly Met
        2115                2120                2125
Gln Pro Gln Pro Gly Met His Gln Gln Pro Ser Leu Gln Asn Leu Asn
    2130                2135                2140
Ala Met Gln Ala Gly Val Pro Arg Pro Gly Val Pro Pro Pro Gln Pro
2145                2150                2155                2160
Ala Met Gly Gly Leu Asn Pro Gln Gly Gln Ala Leu Asn Ile Met Asn
                2165                2170                2175
Pro Gly His Asn Pro Asn Met Thr Asn Met Asn Pro Gln Tyr Arg Glu
            2180                2185                2190
Met Val Arg Arg Gln Leu Leu Gln His Gln Gln Gln Gln Gln Gln Gln
        2195                2200                2205
Gln Gln Gln Gln Gln Gln Gln Gln Asn Ser Ala Ser Leu Ala Gly Gly
    2210                2215                2220
Met Ala Gly His Ser Gln Phe Gln Gln Pro Gln Gly Pro Gly Gly Tyr
2225                2230                2235                2240
Ala Pro Ala Met Gln Gln Gln Arg Met Gln Gln His Leu Pro Ile Gln
                2245                2250                2255
Gly Ser Ser Met Gly Gln Met Ala Ala Pro Met Gly Gln Leu Gly Gln
            2260                2265                2270
Met Gly Gln Pro Gly Leu Gly Ala Asp Ser Thr Pro Asn Ile Gln Gln
        2275                2280                2285
Ala Leu Gln Gln Arg Ile Leu Gln Gln Gln Gln Met Lys Gln Gln Ile
    2290                2295                2300
Gly Ser Pro Gly Gln Pro Asn Pro Met Ser Pro Gln Gln His Met Leu
2305                2310                2315                2320
Ser Gly Gln Pro Gln Ala Ser His Leu Pro Gly Gln Gln Ile Ala Thr
                2325                2330                2335
Ser Leu Ser Asn Gln Val Arg Ser Pro Ala Pro Val Gln Ser Pro Arg
            2340                2345                2350
Pro Gln Ser Gln Pro Pro His Ser Ser Pro Ser Pro Arg Ile Gln Pro
        2355                2360                2365
Gln Pro Ser Pro His His Val Ser Pro Gln Thr Gly Thr Pro His Pro
    2370                2375                2380
Gly Leu Ala Val Thr Met Ala Ser Ser Met Asp Gln Gly His Leu Gly
2385                2390                2395                2400
Asn Pro Glu Gln Ser Ala Met Leu Pro Gln Leu Asn Thr Pro Asn Arg
                2405                2410                2415
Ser Ala Leu Ser Ser Glu Leu Ser Leu Val Gly Asp Thr Thr Gly Asp
            2420                2425                2430
Thr Leu Glu Lys Phe Val Glu Gly Leu
        2435                2440

<210> 644
<211> 2414
<212> PRT
<213> Homo sapiens

<400> 644
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro
 1               5                  10                  15
Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp
            20                  25                  30
Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile
        35                  40                  45
Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu
    50                  55                  60
Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln
65                  70                  75                  80
Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly
                85                  90                  95
Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser
            100                 105                 110
Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln
        115                 120                 125
Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn
    130                 135                 140
Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln
145                 150                 155                 160
Pro Ala Met Gly Met Asn Thr Gly Thr Asn Ala Gly Met Asn Pro Gly
                165                 170                 175
Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met
            180                 185                 190
Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asp Met Gln Tyr Pro
        195                 200                 205
Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln
    210                 215                 220
Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln
225                 230                 235                 240
Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro
                245                 250                 255
Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu
            260                 265                 270
Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala
        275                 280                 285
Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln
    290                 295                 300
Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala
305                 310                 315                 320
Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys
                325                 330                 335
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
            340                 345                 350
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His
        355                 360                 365
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser
    370                 375                 380
Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
385                 390                 395                 400
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
                405                 410                 415
Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly
            420                 425                 430
Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln
        435                 440                 445
Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile
    450                 455                 460
Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met
465                 470                 475                 480
Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro
                485                 490                 495
Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser
            500                 505                 510
Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu
        515                 520                 525
Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met
    530                 535                 540
Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala
545                 550                 555                 560
Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr
                565                 570                 575
Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe
            580                 585                 590
Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu
        595                 600                 605
Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn
    610                 615                 620
Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile
625                 630                 635                 640
Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn
                645                 650                 655
Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly
            660                 665                 670
Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu
        675                 680                 685
Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro
    690                 695                 700
Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met
705                 710                 715                 720
Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His
                725                 730                 735
Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly
            740                 745                 750
Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr
        755                 760                 765
Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro
    770                 775                 780
Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser
785                 790                 795                 800
Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His
                805                 810                 815
Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro
            820                 825                 830
Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser
        835                 840                 845
Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro
    850                 855                 860
Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro
865                 870                 875                 880
Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln
                885                 890                 895
Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln
            900                 905                 910
Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Asn
        915                 920                 925
Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala
    930                 935                 940
Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr
945                 950                 955                 960
Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val
                965                 970                 975
Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr
            980                 985                 990
Gln Pro Glu Asp Ile Ser Glu Ser Lys Val Glu Asp Cys Lys Met Glu
        995                 1000                1005
Ser Thr Glu Thr Glu Glu Arg Ser Thr Glu Leu Lys Thr Glu Ile Lys
    1010                1015                1020
Glu Glu Glu Asp Gln Pro Ser Thr Ser Ala Thr Gln Ser Ser Pro Ala
1025                1030                1035                1040
Pro Gly Gln Ser Lys Lys Lys Ile Phe Lys Pro Glu Glu Leu Arg Gln
                1045                1050                1055
Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp Pro Glu Ser
            1060                1065                1070
Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly Ile Pro Asp
        1075                1080                1085
Tyr Phe Asp Ile Val Lys Ser Pro Met Asp Leu Ser Thr Ile Lys Arg
    1090                1095                1100
Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr Val Asp Asp
1105                1110                1115                1120
Ile Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg Lys Thr Ser
                1125                1130                1135
Arg Val Tyr Lys Tyr Cys Ser Lys Leu Ser Glu Val Phe Glu Gln Glu
            1140                1145                1150
Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly Arg Lys Leu
        1155                1160                1165
Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln Leu Cys Thr
    1170                1175                1180
Ile Pro Arg Asp Ala Thr Tyr Tyr Ser Tyr Gln Asn Arg Tyr His Phe
1185                1190                1195                1200
Cys Glu Lys Cys Phe Asn Glu Ile Gln Gly Glu Ser Val Ser Leu Gly
                1205                1210                1215
Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Asn Lys Glu Gln Phe Ser
            1220                1225                1230
Lys Arg Lys Asn Asp Thr Leu Asp Pro Glu Leu Phe Val Glu Cys Thr
        1235                1240                1245
Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu His His Glu Ile
    1250                1255                1260
Ile Trp Pro Ala Gly Phe Val Cys Asp Gly Cys Leu Lys Lys Ser Ala
1265                1270                1275                1280
Arg Thr Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Pro Ser Thr
                1285                1290                1295
Arg Leu Gly Thr Phe Leu Glu Asn Arg Val Asn Asp Phe Leu Arg Arg
            1300                1305                1310
Gln Asn His Pro Glu Ser Gly Glu Val Thr Val Arg Val Val His Ala
        1315                1320                1325
Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys Ala Arg Phe Val
    1330                1335                1340
Asp Ser Gly Glu Met Ala Glu Ser Phe Pro Tyr Arg Thr Lys Ala Leu
1345                1350                1355                1360
Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Leu Cys Phe Phe Gly Met
                1365                1370                1375
His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Gln Arg Arg
            1380                1385                1390
Val Tyr Ile Ser Tyr Leu Asp Ser Val His Phe Phe Arg Pro Lys Cys
        1395                1400                1405
Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly Tyr Leu Glu Tyr
    1410                1415                1420
Val Lys Lys Leu Gly Tyr Thr Thr Gly His Ile Trp Ala Cys Pro Pro
1425                1430                1435                1440
Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro Pro Asp Gln Lys
                1445                1450                1455
Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys Lys Met Leu Asp
            1460                1465                1470
Lys Ala Val Ser Glu Arg Ile Val His Asp Tyr Lys Asp Ile Phe Lys
        1475                1480                1485
Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu Leu Pro Tyr Phe
    1490                1495                1500
Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser Ile Lys Glu Leu
1505                1510                1515                1520
Glu Gln Glu Glu Glu Glu Arg Lys Arg Glu Glu Asn Thr Ser Asn Glu
                1525                1530                1535
Ser Thr Asp Val Thr Lys Gly Asp Ser Lys Asn Ala Lys Lys Lys Asn
            1540                1545                1550
Asn Lys Lys Thr Ser Lys Asn Lys Ser Ser Leu Ser Arg Gly Asn Lys
        1555                1560                1565
Lys Lys Pro Gly Met Pro Asn Val Ser Asn Asp Leu Ser Gln Lys Leu
    1570                1575                1580
Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe Phe Val Ile Arg Leu
1585                1590                1595                1600
Ile Ala Gly Pro Ala Ala Asn Ser Leu Pro Pro Ile Val Asp Pro Asp
                1605                1610                1615
Pro Leu Ile Pro Cys Asp Leu Met Asp Gly Arg Asp Ala Phe Leu Thr
            1620                1625                1630
Leu Ala Arg Asp Lys His Leu Glu Phe Ser Ser Leu Arg Arg Ala Gln
        1635                1640                1645
Trp Ser Thr Met Cys Met Leu Val Glu Leu His Thr Gln Ser Gln Asp
    1650                1655                1660
Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His His Val Glu Thr Arg
1665                1670                1675                1680
Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu Cys Ile Thr Cys Tyr
                1685                1690                1695
Asn Thr Lys Asn His Asp His Lys Met Glu Lys Leu Gly Leu Gly Leu
            1700                1705                1710
Asp Asp Glu Ser Asn Asn Gln Gln Ala Ala Ala Thr Gln Ser Pro Gly
        1715                1720                1725
Asp Ser Arg Arg Leu Ser Ile Gln Arg Cys Ile Gln Ser Leu Val His
    1730                1735                1740
Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu Pro Ser Cys Gln Lys
1745                1750                1755                1760
Met Lys Arg Val Val Gln His Thr Lys Gly Cys Lys Arg Lys Thr Asn
                1765                1770                1775
Gly Gly Cys Pro Ile Cys Lys Gln Leu Ile Ala Leu Cys Cys Tyr His
            1780                1785                1790
Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val Pro Phe Cys Leu Asn
        1795                1800                1805
Ile Lys Gln Lys Leu Arg Gln Gln Gln Leu Gln His Arg Leu Gln Gln
    1810                1815                1820
Ala Gln Met Leu Arg Arg Arg Met Ala Ser Met Gln Arg Thr Gly Val
1825                1830                1835                1840
Val Gly Gln Gln Gln Gly Leu Pro Ser Pro Thr Pro Ala Thr Pro Thr
                1845                1850                1855
Thr Pro Thr Gly Gln Gln Pro Thr Thr Pro Gln Thr Pro Gln Pro Thr
            1860                1865                1870
Ser Gln Pro Gln Pro Thr Pro Pro Asn Ser Met Pro Pro Tyr Leu Pro
        1875                1880                1885
Arg Thr Gln Ala Ala Gly Pro Val Ser Gln Gly Lys Ala Ala Gly Gln
    1890                1895                1900
Val Thr Pro Pro Thr Pro Pro Gln Thr Ala Gln Pro Pro Leu Pro Gly
1905                1910                1915                1920
Pro Pro Pro Thr Ala Val Glu Met Ala Met Gln Ile Gln Arg Ala Ala
                1925                1930                1935
Glu Thr Gln Arg Gln Met Ala His Val Gln Ile Phe Gln Arg Pro Ile
            1940                1945                1950
Gln His Gln Met Pro Pro Met Thr Pro Met Ala Pro Met Gly Met Asn
        1955                1960                1965
Pro Pro Pro Met Thr Arg Gly Pro Ser Gly His Leu Glu Pro Gly Met
    1970                1975                1980
Gly Pro Thr Gly Met Gln Gln Gln Pro Pro Trp Ser Gln Gly Gly Leu
1985                1990                1995                2000
Pro Gln Pro Gln Gln Leu Gln Ser Gly Met Pro Arg Pro Ala Met Met
                2005                2010                2015
Ser Val Ala Gln His Gly Gln Pro Leu Asn Met Ala Pro Gln Pro Gly
            2020                2025                2030
Leu Gly Gln Val Gly Ile Ser Pro Leu Lys Pro Gly Thr Val Ser Gln
        2035                2040                2045
Gln Ala Leu Gln Asn Leu Leu Arg Thr Leu Arg Ser Pro Ser Ser Pro
    2050                2055                2060
Leu Gln Gln Gln Gln Val Leu Ser Ile Leu His Ala Asn Pro Gln Leu
2065                2070                2075                2080
Leu Ala Ala Phe Ile Lys Gln Arg Ala Ala Lys Tyr Ala Asn Ser Asn
                2085                2090                2095
Pro Gln Pro Ile Pro Gly Gln Pro Gly Met Pro Gln Gly Gln Pro Gly
            2100                2105                2110
Leu Gln Pro Pro Thr Met Pro Gly Gln Gln Gly Val His Ser Asn Pro
        2115                2120                2125
Ala Met Gln Asn Met Asn Pro Met Gln Ala Gly Val Gln Arg Ala Gly
    2130                2135                2140
Leu Pro Gln Gln Gln Pro Gln Gln Gln Leu Gln Pro Pro Met Gly Gly
2145                2150                2155                2160
Met Ser Pro Gln Ala Gln Gln Met Asn Met Asn His Asn Thr Met Pro
                2165                2170                2175
Ser Gln Phe Arg Asp Ile Leu Arg Arg Gln Gln Met Met Gln Gln Gln
            2180                2185                2190
Gln Gln Gln Gly Ala Gly Pro Gly Ile Gly Pro Gly Met Ala Asn His
        2195                2200                2205
Asn Gln Phe Gln Gln Pro Gln Gly Val Gly Tyr Pro Pro Gln Pro Gln
    2210                2215                2220
Gln Arg Met Gln His His Met Gln Gln Met Gln Gln Gly Asn Met Gly
2225                2230                2235                2240
Gln Ile Gly Gln Leu Pro Gln Ala Leu Gly Ala Glu Ala Gly Ala Ser
                2245                2250                2255
Leu Gln Ala Tyr Gln Gln Arg Leu Leu Gln Gln Gln Met Gly Ser Pro
            2260                2265                2270
Val Gln Pro Asn Pro Met Ser Pro Gln Gln His Met Leu Pro Asn Gln
        2275                2280                2285
Ala Gln Ser Pro His Leu Gln Gly Gln Gln Ile Pro Asn Ser Leu Ser
    2290                2295                2300
Asn Gln Val Arg Ser Pro Gln Pro Val Pro Ser Pro Arg Pro Gln Ser
2305                2310                2315                2320
Gln Pro Pro His Ser Ser Pro Ser Pro Arg Met Gln Pro Gln Pro Ser
                2325                2330                2335
Pro His His Val Ser Pro Gln Thr Ser Ser Pro His Pro Gly Leu Val
            2340                2345                2350
Ala Ala Gln Ala Asn Pro Met Glu Gln Gly His Phe Ala Ser Pro Asp
        2355                2360                2365
Gln Asn Ser Met Leu Ser Gln Leu Ala Ser Asn Pro Gly Met Ala Asn
    2370                2375                2380
Leu His Gly Ala Ser Ala Thr Asp Leu Gly Leu Ser Thr Asp Asn Ser
2385                2390                2395                2400
Asp Leu Asn Ser Asn Leu Ser Gln Ser Thr Leu Asp Ile His
                2405                2410

<210> 645
<211> 2442
<212> PRT
<213> Homo sapiens

<400> 645
Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys
 1               5                  10                  15
Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser
            20                  25                  30
Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly
        35                  40                  45
Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala
    50                  55                  60
Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser
65                  70                  75                  80
Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln
                85                  90                  95
Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met
            100                 105                 110
Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser
        115                 120                 125
Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr
    130                 135                 140
Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly
145                 150                 155                 160
Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys
                165                 170                 175
Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn
            180                 185                 190
Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val
        195                 200                 205
Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met
    210                 215                 220
Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala
225                 230                 235                 240
Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu
                245                 250                 255
Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn
            260                 265                 270
Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met
        275                 280                 285
Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val
    290                 295                 300
Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr
305                 310                 315                 320
Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro
                325                 330                 335
Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys
            340                 345                 350
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
        355                 360                 365
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His
    370                 375                 380
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala
385                 390                 395                 400
Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
                405                 410                 415
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
            420                 425                 430
Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser
        435                 440                 445
Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln
    450                 455                 460
Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser
465                 470                 475                 480
Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro
                485                 490                 495
Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro
            500                 505                 510
Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro
        515                 520                 525
Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn
    530                 535                 540
Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro
545                 550                 555                 560
Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr
                565                 570                 575
Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp
            580                 585                 590
His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu
        595                 600                 605
Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg
    610                 615                 620
Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met
625                 630                 635                 640
Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu
                645                 650                 655
Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg
            660                 665                 670
Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro
        675                 680                 685
Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro
    690                 695                 700
Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly
705                 710                 715                 720
Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln
                725                 730                 735
Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln
            740                 745                 750
Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg
        755                 760                 765
Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met
    770                 775                 780
Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro
785                 790                 795                 800
Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln
                805                 810                 815
Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro
            820                 825                 830
Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val
        835                 840                 845
Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala
    850                 855                 860
Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro
865                 870                 875                 880
Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly
                885                 890                 895
Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr
            900                 905                 910
Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro
        915                 920                 925
Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser
    930                 935                 940
Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro
945                 950                 955                 960
Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser
                965                 970                 975
Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val
            980                 985                 990
Pro Val Leu Glu Met Lys Thr Glu Thr Gln Ala Glu Asp Thr Glu Pro
        995                 1000                1005
Asp Pro Gly Glu Ser Lys Gly Glu Pro Arg Ser Glu Met Met Glu Glu
    1010                1015                1020
Asp Leu Gln Gly Ala Ser Gln Val Lys Glu Glu Thr Asp Ile Ala Glu
1025                1030                1035                1040
Gln Lys Ser Glu Pro Met Glu Val Asp Glu Lys Lys Pro Glu Val Lys
                1045                1050                1055
Val Glu Val Lys Glu Glu Glu Glu Ser Ser Ser Asn Gly Thr Ala Ser
            1060                1065                1070
Gln Ser Thr Ser Pro Ser Gln Pro Arg Lys Lys Ile Phe Lys Pro Glu
        1075                1080                1085
Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln
    1090                1095                1100
Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu
1105                1110                1115                1120
Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn Pro Met Asp Leu Ser
                1125                1130                1135
Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln
            1140                1145                1150
Tyr Val Asp Asp Val Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn
        1155                1160                1165
Arg Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser Lys Leu Ala Glu Val
    1170                1175                1180
Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys
1185                1190                1195                1200
Gly Arg Lys Tyr Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys
                1205                1210                1215
Gln Leu Cys Thr Ile Pro Arg Asp Ala Ala Tyr Tyr Ser Tyr Gln Asn
            1220                1225                1230
Arg Tyr His Phe Cys Glu Lys Cys Phe Thr Glu Ile Gln Gly Glu Asn
        1235                1240                1245
Val Thr Leu Gly Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Ser Lys
    1250                1255                1260
Asp Gln Phe Glu Lys Lys Lys Asn Asp Thr Leu Asp Pro Glu Pro Phe
1265                1270                1275                1280
Val Asp Cys Lys Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu
                1285                1290                1295
His Tyr Asp Ile Ile Trp Pro Ser Gly Phe Val Cys Asp Asn Cys Leu
            1300                1305                1310
Lys Lys Thr Gly Arg Pro Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg
        1315                1320                1325
Leu Gln Thr Thr Arg Leu Gly Asn His Leu Glu Asp Arg Val Asn Lys
    1330                1335                1340
Phe Leu Arg Arg Gln Asn His Pro Glu Ala Gly Glu Val Phe Val Arg
1345                1350                1355                1360
Val Val Ala Ser Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys
                1365                1370                1375
Ser Arg Phe Val Asp Ser Gly Glu Met Ser Glu Ser Phe Pro Tyr Arg
            1380                1385                1390
Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Val Cys
        1395                1400                1405
Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro
    1410                1415                1420
Asn Thr Arg Arg Val Tyr Ile Ser Tyr Leu Asp Ser Ile His Phe Phe
1425                1430                1435                1440
Arg Pro Arg Cys Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly
                1445                1450                1455
Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Val Thr Gly His Ile Trp
            1460                1465                1470
Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro
        1475                1480                1485
Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys
    1490                1495                1500
Lys Met Leu Asp Lys Ala Phe Ala Glu Arg Ile Ile His Asp Tyr Lys
1505                1510                1515                1520
Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu
                1525                1530                1535
Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser
            1540                1545                1550
Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg Lys Lys Glu Glu Ser
        1555                1560                1565
Thr Ala Ala Ser Glu Thr Thr Glu Gly Ser Gln Gly Asp Ser Lys Asn
    1570                1575                1580
Ala Lys Lys Lys Asn Asn Lys Lys Thr Asn Lys Asn Lys Ser Ser Ile
1585                1590                1595                1600
Ser Arg Ala Asn Lys Lys Lys Pro Ser Met Pro Asn Val Ser Asn Asp
                1605                1610                1615
Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe
            1620                1625                1630
Phe Val Ile His Leu His Ala Gly Pro Val Ile Asn Thr Leu Pro Pro
        1635                1640                1645
Ile Val Asp Pro Asp Pro Leu Leu Ser Cys Asp Leu Met Asp Gly Arg
    1650                1655                1660
Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Trp Glu Phe Ser Ser
1665                1670                1675                1680
Leu Arg Arg Ser Lys Trp Ser Thr Leu Cys Met Leu Val Glu Leu His
                1685                1690                1695
Thr Gln Gly Gln Asp Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His
            1700                1705                1710
His Val Glu Thr Arg Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu
        1715                1720                1725
Cys Ile Asn Cys Tyr Asn Thr Lys Ser His Ala His Lys Met Val Lys
    1730                1735                1740
Trp Gly Leu Gly Leu Asp Asp Glu Gly Ser Ser Gln Gly Glu Pro Gln
1745                1750                1755                1760
Ser Lys Ser Pro Gln Glu Ser Arg Arg Val Ser Ile Gln Arg Cys Ile
                1765                1770                1775
Gln Ser Leu Val His Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu
            1780                1785                1790
Pro Ser Cys Gln Lys Met Lys Arg Val Val Gln His Thr Lys Gly Cys
        1795                1800                1805
Lys Arg Lys Thr Asn Gly Gly Cys Pro Val Cys Lys Gln Leu Ile Ala
    1810                1815                1820
Leu Cys Cys Tyr His Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val
1825                1830                1835                1840
Pro Phe Cys Leu Asn Ile Lys His Lys Leu Arg Gln Gln Gln Ile Gln
                1845                1850                1855
His Arg Leu Gln Gln Ala Gln Leu Met Arg Arg Arg Met Ala Thr Met
            1860                1865                1870
Asn Thr Arg Asn Val Pro Gln Gln Ser Leu Pro Ser Pro Thr Ser Ala
        1875                1880                1885
Pro Pro Gly Thr Pro Thr Gln Gln Pro Ser Thr Pro Gln Thr Pro Gln
    1890                1895                1900
Pro Pro Ala Gln Pro Gln Pro Ser Pro Val Ser Met Ser Pro Ala Gly
1905                1910                1915                1920
Phe Pro Ser Val Ala Arg Thr Gln Pro Pro Thr Thr Val Ser Thr Gly
                1925                1930                1935
Lys Pro Thr Ser Gln Val Pro Ala Pro Pro Pro Pro Ala Gln Pro Pro
            1940                1945                1950
Pro Ala Ala Val Glu Ala Ala Arg Gln Ile Glu Arg Glu Ala Gln Gln
        1955                1960                1965
Gln Gln His Leu Tyr Arg Val Asn Ile Asn Asn Ser Met Pro Pro Gly
    1970                1975                1980
Arg Thr Gly Met Gly Thr Pro Gly Ser Gln Met Ala Pro Val Ser Leu
1985                1990                1995                2000
Asn Val Pro Arg Pro Asn Gln Val Ser Gly Pro Val Met Pro Ser Met
                2005                2010                2015
Pro Pro Gly Gln Trp Gln Gln Ala Pro Leu Pro Gln Gln Gln Pro Met
            2020                2025                2030
Pro Gly Leu Pro Arg Pro Val Ile Ser Met Gln Ala Gln Ala Ala Val
        2035                2040                2045
Ala Gly Pro Arg Met Pro Ser Val Gln Pro Pro Arg Ser Ile Ser Pro
    2050                2055                2060
Ser Ala Leu Gln Asp Leu Leu Arg Thr Leu Lys Ser Pro Ser Ser Pro
2065                2070                2075                2080
Gln Gln Gln Gln Gln Val Leu Asn Ile Leu Lys Ser Asn Pro Gln Leu
                2085                2090                2095
Met Ala Ala Phe Ile Lys Gln Arg Thr Ala Lys Tyr Val Ala Asn Gln
            2100                2105                2110
Pro Gly Met Gln Pro Gln Pro Gly Leu Gln Ser Gln Pro Gly Met Gln
        2115                2120                2125
Pro Gln Pro Gly Met His Gln Gln Pro Ser Leu Gln Asn Leu Asn Ala
    2130                2135                2140
Met Gln Ala Gly Val Pro Arg Pro Gly Val Pro Pro Gln Gln Gln Ala
2145                2150                2155                2160
Met Gly Gly Leu Asn Pro Gln Gly Gln Ala Leu Asn Ile Met Asn Pro
                2165                2170                2175
Gly His Asn Pro Asn Met Ala Ser Met Asn Pro Gln Tyr Arg Glu Met
            2180                2185                2190
Leu Arg Arg Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        2195                2200                2205
Gln Gln Gln Gln Gln Gln Gln Gln Gly Ser Ala Gly Met Ala Gly Gly
    2210                2215                2220
Met Ala Gly His Gly Gln Phe Gln Gln Pro Gln Gly Pro Gly Gly Tyr
2225                2230                2235                2240
Pro Pro Ala Met Gln Gln Gln Gln Arg Met Gln Gln His Leu Pro Leu
                2245                2250                2255
Gln Gly Ser Ser Met Gly Gln Met Ala Ala Gln Met Gly Gln Leu Gly
            2260                2265                2270
Gln Met Gly Gln Pro Gly Leu Gly Ala Asp Ser Thr Pro Asn Ile Gln
        2275                2280                2285
Gln Ala Leu Gln Gln Arg Ile Leu Gln Gln Gln Gln Met Lys Gln Gln
    2290                2295                2300
Ile Gly Ser Pro Gly Gln Pro Asn Pro Met Ser Pro Gln Gln His Met
2305                2310                2315                2320
Leu Ser Gly Gln Pro Gln Ala Ser His Leu Pro Gly Gln Gln Ile Ala
                2325                2330                2335
Thr Ser Leu Ser Asn Gln Val Arg Ser Pro Ala Pro Val Gln Ser Pro
            2340                2345                2350
Arg Pro Gln Ser Gln Pro Pro His Ser Ser Pro Ser Pro Arg Ile Gln
        2355                2360                2365
Pro Gln Pro Ser Pro His His Val Ser Pro Gln Thr Gly Ser Pro His
    2370                2375                2380
Pro Gly Leu Ala Val Thr Met Ala Ser Ser Ile Asp Gln Gly His Leu
2385                2390                2395                2400
Gly Asn Pro Glu Gln Ser Ala Met Leu Pro Gln Leu Asn Thr Pro Ser
                2405                2410                2415
Arg Ser Ala Leu Ser Ser Glu Leu Ser Leu Val Gly Asp Thr Thr Gly
            2420                2425                2430
Asp Thr Leu Glu Lys Phe Val Glu Gly Leu
        2435                2440

<210> 646
<211> 2414
<212> PRT
<213> Homo sapiens

<400> 646
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro
 1               5                  10                  15
Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp
            20                  25                  30
Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile
        35                  40                  45
Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu
    50                  55                  60
Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln
65                  70                  75                  80
Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly
                85                  90                  95
Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser
            100                 105                 110
Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln
        115                 120                 125
Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn
    130                 135                 140
Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln
145                 150                 155                 160
Pro Ala Met Gly Met Asn Thr Gly Thr Asn Ala Gly Met Asn Pro Gly
                165                 170                 175
Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met
            180                 185                 190
Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asp Met Gln Tyr Pro
        195                 200                 205
Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln
    210                 215                 220
Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln
225                 230                 235                 240
Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro
                245                 250                 255
Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu
            260                 265                 270
Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala
        275                 280                 285
Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln
    290                 295                 300
Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala
305                 310                 315                 320
Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys
                325                 330                 335
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
            340                 345                 350
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His
        355                 360                 365
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser
    370                 375                 380
Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
385                 390                 395                 400
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
                405                 410                 415
Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly
            420                 425                 430
Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln
        435                 440                 445
Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile
    450                 455                 460
Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met
465                 470                 475                 480
Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro
                485                 490                 495
Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser
            500                 505                 510
Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu
        515                 520                 525
Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met
    530                 535                 540
Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala
545                 550                 555                 560
Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr
                565                 570                 575
Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe
            580                 585                 590
Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu
        595                 600                 605
Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn
    610                 615                 620
Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile
625                 630                 635                 640
Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn
                645                 650                 655
Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly
            660                 665                 670
Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu
        675                 680                 685
Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro
    690                 695                 700
Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met
705                 710                 715                 720
Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His
                725                 730                 735
Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly
            740                 745                 750
Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr
        755                 760                 765
Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro
    770                 775                 780
Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser
785                 790                 795                 800
Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His
                805                 810                 815
Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro
            820                 825                 830
Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser
        835                 840                 845
Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro
    850                 855                 860
Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro
865                 870                 875                 880
Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln
                885                 890                 895
Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln
            900                 905                 910
Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Asn
        915                 920                 925
Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala
    930                 935                 940
Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr
945                 950                 955                 960
Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val
                965                 970                 975
Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr
            980                 985                 990
Gln Pro Glu Asp Ile Ser Glu Ser Lys Val Glu Asp Cys Lys Met Glu
        995                 1000                1005
Ser Thr Glu Thr Glu Glu Arg Ser Thr Glu Leu Lys Thr Glu Ile Lys
    1010                1015                1020
Glu Glu Glu Asp Gln Pro Ser Thr Ser Ala Thr Gln Ser Ser Pro Ala
1025                1030                1035                1040
Pro Gly Gln Ser Lys Lys Lys Ile Phe Lys Pro Glu Glu Leu Arg Gln
                1045                1050                1055
Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp Pro Glu Ser
            1060                1065                1070
Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly Ile Pro Asp
        1075                1080                1085
Tyr Phe Asp Ile Val Lys Ser Pro Met Asp Leu Ser Thr Ile Lys Arg
    1090                1095                1100
Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr Val Asp Asp
1105                1110                1115                1120
Ile Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg Lys Thr Ser
                1125                1130                1135
Arg Val Tyr Lys Tyr Cys Ser Lys Leu Ser Glu Val Phe Glu Gln Glu
            1140                1145                1150
Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly Arg Lys Leu
        1155                1160                1165
Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln Leu Cys Thr
    1170                1175                1180
Ile Pro Arg Asp Ala Thr Tyr Tyr Ser Tyr Gln Asn Arg Tyr His Phe
1185                1190                1195                1200
Cys Glu Lys Cys Phe Asn Glu Ile Gln Gly Glu Ser Val Ser Leu Gly
                1205                1210                1215
Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Asn Lys Glu Gln Phe Ser
            1220                1225                1230
Lys Arg Lys Asn Asp Thr Leu Asp Pro Glu Leu Phe Val Glu Cys Thr
        1235                1240                1245
Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu His His Glu Ile
    1250                1255                1260
Ile Trp Pro Ala Gly Phe Val Cys Asp Gly Cys Leu Lys Lys Ser Ala
1265                1270                1275                1280
Arg Thr Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Pro Ser Thr
                1285                1290                1295
Arg Leu Gly Thr Phe Leu Glu Asn Arg Val Asn Asp Phe Leu Arg Arg
            1300                1305                1310
Gln Asn His Pro Glu Ser Gly Glu Val Thr Val Arg Val Val His Ala
        1315                1320                1325
Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys Ala Arg Phe Val
    1330                1335                1340
Asp Ser Gly Glu Met Ala Glu Ser Phe Pro Tyr Arg Thr Lys Ala Leu
1345                1350                1355                1360
Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Leu Cys Phe Phe Gly Met
                1365                1370                1375
His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Gln Arg Arg
            1380                1385                1390
Val Tyr Ile Ser Tyr Leu Asp Ser Val His Phe Phe Arg Pro Lys Cys
        1395                1400                1405
Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly Tyr Leu Glu Tyr
    1410                1415                1420
Val Lys Lys Leu Gly Tyr Thr Thr Gly His Ile Trp Ala Cys Pro Pro
1425                1430                1435                1440
Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro Pro Asp Gln Lys
                1445                1450                1455
Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys Lys Met Leu Asp
            1460                1465                1470
Lys Ala Val Ser Glu Arg Ile Val His Asp Tyr Lys Asp Ile Phe Lys
        1475                1480                1485
Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu Leu Pro Tyr Phe
    1490                1495                1500
Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser Ile Lys Glu Leu
1505                1510                1515                1520
Glu Gln Glu Glu Glu Glu Arg Lys Arg Glu Glu Asn Thr Ser Asn Glu
                1525                1530                1535
Ser Thr Asp Val Thr Lys Gly Asp Ser Lys Asn Ala Lys Lys Lys Asn
            1540                1545                1550
Asn Lys Lys Thr Ser Lys Asn Lys Ser Ser Leu Ser Arg Gly Asn Lys
        1555                1560                1565
Lys Lys Pro Gly Met Pro Asn Val Ser Asn Asp Leu Ser Gln Lys Leu
    1570                1575                1580
Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe Phe Val Ile Arg Leu
1585                1590                1595                1600
Ile Ala Gly Pro Ala Ala Asn Ser Leu Pro Pro Ile Val Asp Pro Asp
                1605                1610                1615
Pro Leu Ile Pro Cys Asp Leu Met Asp Gly Arg Asp Ala Phe Leu Thr
            1620                1625                1630
Leu Ala Arg Asp Lys His Leu Glu Phe Ser Ser Leu Arg Arg Ala Gln
        1635                1640                1645
Trp Ser Thr Met Cys Met Leu Val Glu Leu His Thr Gln Ser Gln Asp
    1650                1655                1660
Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His His Val Glu Thr Arg
1665                1670                1675                1680
Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu Cys Ile Thr Cys Tyr
                1685                1690                1695
Asn Thr Lys Asn His Asp His Lys Met Glu Lys Leu Gly Leu Gly Leu
            1700                1705                1710
Asp Asp Glu Ser Asn Asn Gln Gln Ala Ala Ala Thr Gln Ser Pro Gly
        1715                1720                1725
Asp Ser Arg Arg Leu Ser Ile Gln Arg Cys Ile Gln Ser Leu Val His
    1730                1735                1740
Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu Pro Ser Cys Gln Lys
1745                1750                1755                1760
Met Lys Arg Val Val Gln His Thr Lys Gly Cys Lys Arg Lys Thr Asn
                1765                1770                1775
Gly Gly Cys Pro Ile Cys Lys Gln Leu Ile Ala Leu Cys Cys Tyr His
            1780                1785                1790
Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val Pro Phe Cys Leu Asn
        1795                1800                1805
Ile Lys Gln Lys Leu Arg Gln Gln Gln Leu Gln His Arg Leu Gln Gln
    1810                1815                1820
Ala Gln Met Leu Arg Arg Arg Met Ala Ser Met Gln Arg Thr Gly Val
1825                1830                1835                1840
Val Gly Gln Gln Gln Gly Leu Pro Ser Pro Thr Pro Ala Thr Pro Thr
                1845                1850                1855
Thr Pro Thr Gly Gln Gln Pro Thr Thr Pro Gln Thr Pro Gln Pro Thr
            1860                1865                1870
Ser Gln Pro Gln Pro Thr Pro Pro Asn Ser Met Pro Pro Tyr Leu Pro
        1875                1880                1885
Arg Thr Gln Ala Ala Gly Pro Val Ser Gln Gly Lys Ala Ala Gly Gln
    1890                1895                1900
Val Thr Pro Pro Thr Pro Pro Gln Thr Ala Gln Pro Pro Leu Pro Gly
1905                1910                1915                1920
Pro Pro Pro Thr Ala Val Glu Met Ala Met Gln Ile Gln Arg Ala Ala
                1925                1930                1935
Glu Thr Gln Arg Gln Met Ala His Val Gln Ile Phe Gln Arg Pro Ile
            1940                1945                1950
Gln His Gln Met Pro Pro Met Thr Pro Met Ala Pro Met Gly Met Asn
        1955                1960                1965
Pro Pro Pro Met Thr Arg Gly Pro Ser Gly His Leu Glu Pro Gly Met
    1970                1975                1980
Gly Pro Thr Gly Met Gln Gln Gln Pro Pro Trp Ser Gln Gly Gly Leu
1985                1990                1995                2000
Pro Gln Pro Gln Gln Leu Gln Ser Gly Met Pro Arg Pro Ala Met Met
                2005                2010                2015
Ser Val Ala Gln His Gly Gln Pro Leu Asn Met Ala Pro Gln Pro Gly
            2020                2025                2030
Leu Gly Gln Val Gly Ile Ser Pro Leu Lys Pro Gly Thr Val Ser Gln
        2035                2040                2045
Gln Ala Leu Gln Asn Leu Leu Arg Thr Leu Arg Ser Pro Ser Ser Pro
    2050                2055                2060
Leu Gln Gln Gln Gln Val Leu Ser Ile Leu His Ala Asn Pro Gln Leu
2065                2070                2075                2080
Leu Ala Ala Phe Ile Lys Gln Arg Ala Ala Lys Tyr Ala Asn Ser Asn
                2085                2090                2095
Pro Gln Pro Ile Pro Gly Gln Pro Gly Met Pro Gln Gly Gln Pro Gly
            2100                2105                2110
Leu Gln Pro Pro Thr Met Pro Gly Gln Gln Gly Val His Ser Asn Pro
        2115                2120                2125
Ala Met Gln Asn Met Asn Pro Met Gln Ala Gly Val Gln Arg Ala Gly
    2130                2135                2140
Leu Pro Gln Gln Gln Pro Gln Gln Gln Leu Gln Pro Pro Met Gly Gly
2145                2150                2155                2160
Met Ser Pro Gln Ala Gln Gln Met Asn Met Asn His Asn Thr Met Pro
                2165                2170                2175
Ser Gln Phe Arg Asp Ile Leu Arg Arg Gln Gln Met Met Gln Gln Gln
            2180                2185                2190
Gln Gln Gln Gly Ala Gly Pro Gly Ile Gly Pro Gly Met Ala Asn His
        2195                2200                2205
Asn Gln Phe Gln Gln Pro Gln Gly Val Gly Tyr Pro Pro Gln Pro Gln
    2210                2215                2220
Gln Arg Met Gln His His Met Gln Gln Met Gln Gln Gly Asn Met Gly
2225                2230                2235                2240
Gln Ile Gly Gln Leu Pro Gln Ala Leu Gly Ala Glu Ala Gly Ala Ser
                2245                2250                2255
Leu Gln Ala Tyr Gln Gln Arg Leu Leu Gln Gln Gln Met Gly Ser Pro
            2260                2265                2270
Val Gln Pro Asn Pro Met Ser Pro Gln Gln His Met Leu Pro Asn Gln
        2275                2280                2285
Ala Gln Ser Pro His Leu Gln Gly Gln Gln Ile Pro Asn Ser Leu Ser
    2290                2295                2300
Asn Gln Val Arg Ser Pro Gln Pro Val Pro Ser Pro Arg Pro Gln Ser
2305                2310                2315                2320
Gln Pro Pro His Ser Ser Pro Ser Pro Arg Met Gln Pro Gln Pro Ser
                2325                2330                2335
Pro His His Val Ser Pro Gln Thr Ser Ser Pro His Pro Gly Leu Val
            2340                2345                2350
Ala Ala Gln Ala Asn Pro Met Glu Gln Gly His Phe Ala Ser Pro Asp
        2355                2360                2365
Gln Asn Ser Met Leu Ser Gln Leu Ala Ser Asn Pro Gly Met Ala Asn
    2370                2375                2380
Leu His Gly Ala Ser Ala Thr Asp Leu Gly Leu Ser Thr Asp Asn Ser
2385                2390                2395                2400
Asp Leu Asn Ser Asn Leu Ser Gln Ser Thr Leu Asp Ile His
                2405                2410

<210> 647
<211> 2442
<212> PRT
<213> Homo sapiens

<400> 647
Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys
 1               5                  10                  15
Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser
            20                  25                  30
Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly
        35                  40                  45
Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala
    50                  55                  60
Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser
65                  70                  75                  80
Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln
                85                  90                  95
Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met
            100                 105                 110
Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser
        115                 120                 125
Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr
    130                 135                 140
Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly
145                 150                 155                 160
Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys
                165                 170                 175
Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn
            180                 185                 190
Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val
        195                 200                 205
Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met
    210                 215                 220
Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala
225                 230                 235                 240
Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu
                245                 250                 255
Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn
            260                 265                 270
Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met
        275                 280                 285
Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val
    290                 295                 300
Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr
305                 310                 315                 320
Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro
                325                 330                 335
Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys
            340                 345                 350
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
        355                 360                 365
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His
    370                 375                 380
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala
385                 390                 395                 400
Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
                405                 410                 415
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
            420                 425                 430
Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser
        435                 440                 445
Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln
    450                 455                 460
Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser
465                 470                 475                 480
Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro
                485                 490                 495
Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro
            500                 505                 510
Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro
        515                 520                 525
Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn
    530                 535                 540
Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro
545                 550                 555                 560
Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr
                565                 570                 575
Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp
            580                 585                 590
His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu
        595                 600                 605
Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg
    610                 615                 620
Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met
625                 630                 635                 640
Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu
                645                 650                 655
Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg
            660                 665                 670
Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro
        675                 680                 685
Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro
    690                 695                 700
Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly
705                 710                 715                 720
Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln
                725                 730                 735
Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln
            740                 745                 750
Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg
        755                 760                 765
Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met
    770                 775                 780
Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro
785                 790                 795                 800
Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln
                805                 810                 815
Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro
            820                 825                 830
Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val
        835                 840                 845
Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala
    850                 855                 860
Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro
865                 870                 875                 880
Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly
                885                 890                 895
Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr
            900                 905                 910
Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro
        915                 920                 925
Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser
    930                 935                 940
Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro
945                 950                 955                 960
Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser
                965                 970                 975
Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val
            980                 985                 990
Pro Val Leu Glu Met Lys Thr Glu Thr Gln Ala Glu Asp Thr Glu Pro
        995                 1000                1005
Asp Pro Gly Glu Ser Lys Gly Glu Pro Arg Ser Glu Met Met Glu Glu
    1010                1015                1020
Asp Leu Gln Gly Ala Ser Gln Val Lys Glu Glu Thr Asp Ile Ala Glu
1025                1030                1035                1040
Gln Lys Ser Glu Pro Met Glu Val Asp Glu Lys Lys Pro Glu Val Lys
                1045                1050                1055
Val Glu Val Lys Glu Glu Glu Glu Ser Ser Ser Asn Gly Thr Ala Ser
            1060                1065                1070
Gln Ser Thr Ser Pro Ser Gln Pro Arg Lys Lys Ile Phe Lys Pro Glu
        1075                1080                1085
Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln
    1090                1095                1100
Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu
1105                1110                1115                1120
Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn Pro Met Asp Leu Ser
                1125                1130                1135
Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln
            1140                1145                1150
Tyr Val Asp Asp Val Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn
        1155                1160                1165
Arg Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser Lys Leu Ala Glu Val
    1170                1175                1180
Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys
1185                1190                1195                1200
Gly Arg Lys Tyr Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys
                1205                1210                1215
Gln Leu Cys Thr Ile Pro Arg Asp Ala Ala Tyr Tyr Ser Tyr Gln Asn
            1220                1225                1230
Arg Tyr His Phe Cys Glu Lys Cys Phe Thr Glu Ile Gln Gly Glu Asn
        1235                1240                1245
Val Thr Leu Gly Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Ser Lys
    1250                1255                1260
Asp Gln Phe Glu Lys Lys Lys Asn Asp Thr Leu Asp Pro Glu Pro Phe
1265                1270                1275                1280
Val Asp Cys Lys Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu
                1285                1290                1295
His Tyr Asp Ile Ile Trp Pro Ser Gly Phe Val Cys Asp Asn Cys Leu
            1300                1305                1310
Lys Lys Thr Gly Arg Pro Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg
        1315                1320                1325
Leu Gln Thr Thr Arg Leu Gly Asn His Leu Glu Asp Arg Val Asn Lys
    1330                1335                1340
Phe Leu Arg Arg Gln Asn His Pro Glu Ala Gly Glu Val Phe Val Arg
1345                1350                1355                1360
Val Val Ala Ser Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys
                1365                1370                1375
Ser Arg Phe Val Asp Ser Gly Glu Met Ser Glu Ser Phe Pro Tyr Arg
            1380                1385                1390
Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Val Cys
        1395                1400                1405
Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro
    1410                1415                1420
Asn Thr Arg Arg Val Tyr Ile Ser Tyr Leu Asp Ser Ile His Phe Phe
1425                1430                1435                1440
Arg Pro Arg Cys Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly
                1445                1450                1455
Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Val Thr Gly His Ile Trp
            1460                1465                1470
Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro
        1475                1480                1485
Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys
    1490                1495                1500
Lys Met Leu Asp Lys Ala Phe Ala Glu Arg Ile Ile His Asp Tyr Lys
1505                1510                1515                1520
Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu
                1525                1530                1535
Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser
            1540                1545                1550
Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg Lys Lys Glu Glu Ser
        1555                1560                1565
Thr Ala Ala Ser Glu Thr Thr Glu Gly Ser Gln Gly Asp Ser Lys Asn
    1570                1575                1580
Ala Lys Lys Lys Asn Asn Lys Lys Thr Asn Lys Asn Lys Ser Ser Ile
1585                1590                1595                1600
Ser Arg Ala Asn Lys Lys Lys Pro Ser Met Pro Asn Val Ser Asn Asp
                1605                1610                1615
Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe
            1620                1625                1630
Phe Val Ile His Leu His Ala Gly Pro Val Ile Asn Thr Leu Pro Pro
        1635                1640                1645
Ile Val Asp Pro Asp Pro Leu Leu Ser Cys Asp Leu Met Asp Gly Arg
    1650                1655                1660
Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Trp Glu Phe Ser Ser
1665                1670                1675                1680
Leu Arg Arg Ser Lys Trp Ser Thr Leu Cys Met Leu Val Glu Leu His
                1685                1690                1695
Thr Gln Gly Gln Asp Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His
            1700                1705                1710
His Val Glu Thr Arg Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu
        1715                1720                1725
Cys Ile Asn Cys Tyr Asn Thr Lys Ser His Ala His Lys Met Val Lys
    1730                1735                1740
Trp Gly Leu Gly Leu Asp Asp Glu Gly Ser Ser Gln Gly Glu Pro Gln
1745                1750                1755                1760
Ser Lys Ser Pro Gln Glu Ser Arg Arg Val Ser Ile Gln Arg Cys Ile
                1765                1770                1775
Gln Ser Leu Val His Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu
            1780                1785                1790
Pro Ser Cys Gln Lys Met Lys Arg Val Val Gln His Thr Lys Gly Cys
        1795                1800                1805
Lys Arg Lys Thr Asn Gly Gly Cys Pro Val Cys Lys Gln Leu Ile Ala
    1810                1815                1820
Leu Cys Cys Tyr His Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val
1825                1830                1835                1840
Pro Phe Cys Leu Asn Ile Lys His Lys Leu Arg Gln Gln Gln Ile Gln
                1845                1850                1855
His Arg Leu Gln Gln Ala Gln Leu Met Arg Arg Arg Met Ala Thr Met
            1860                1865                1870
Asn Thr Arg Asn Val Pro Gln Gln Ser Leu Pro Ser Pro Thr Ser Ala
        1875                1880                1885
Pro Pro Gly Thr Pro Thr Gln Gln Pro Ser Thr Pro Gln Thr Pro Gln
    1890                1895                1900
Pro Pro Ala Gln Pro Gln Pro Ser Pro Val Ser Met Ser Pro Ala Gly
1905                1910                1915                1920
Phe Pro Ser Val Ala Arg Thr Gln Pro Pro Thr Thr Val Ser Thr Gly
                1925                1930                1935
Lys Pro Thr Ser Gln Val Pro Ala Pro Pro Pro Pro Ala Gln Pro Pro
            1940                1945                1950
Pro Ala Ala Val Glu Ala Ala Arg Gln Ile Glu Arg Glu Ala Gln Gln
        1955                1960                1965
Gln Gln His Leu Tyr Arg Val Asn Ile Asn Asn Ser Met Pro Pro Gly
    1970                1975                1980
Arg Thr Gly Met Gly Thr Pro Gly Ser Gln Met Ala Pro Val Ser Leu
1985                1990                1995                2000
Asn Val Pro Arg Pro Asn Gln Val Ser Gly Pro Val Met Pro Ser Met
                2005                2010                2015
Pro Pro Gly Gln Trp Gln Gln Ala Pro Leu Pro Gln Gln Gln Pro Met
            2020                2025                2030
Pro Gly Leu Pro Arg Pro Val Ile Ser Met Gln Ala Gln Ala Ala Val
        2035                2040                2045
Ala Gly Pro Arg Met Pro Ser Val Gln Pro Pro Arg Ser Ile Ser Pro
    2050                2055                2060
Ser Ala Leu Gln Asp Leu Leu Arg Thr Leu Lys Ser Pro Ser Ser Pro
2065                2070                2075                2080
Gln Gln Gln Gln Gln Val Leu Asn Ile Leu Lys Ser Asn Pro Gln Leu
                2085                2090                2095
Met Ala Ala Phe Ile Lys Gln Arg Thr Ala Lys Tyr Val Ala Asn Gln
            2100                2105                2110
Pro Gly Met Gln Pro Gln Pro Gly Leu Gln Ser Gln Pro Gly Met Gln
        2115                2120                2125
Pro Gln Pro Gly Met His Gln Gln Pro Ser Leu Gln Asn Leu Asn Ala
    2130                2135                2140
Met Gln Ala Gly Val Pro Arg Pro Gly Val Pro Pro Gln Gln Gln Ala
2145                2150                2155                2160
Met Gly Gly Leu Asn Pro Gln Gly Gln Ala Leu Asn Ile Met Asn Pro
                2165                2170                2175
Gly His Asn Pro Asn Met Ala Ser Met Asn Pro Gln Tyr Arg Glu Met
            2180                2185                2190
Leu Arg Arg Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        2195                2200                2205
Gln Gln Gln Gln Gln Gln Gln Gln Gly Ser Ala Gly Met Ala Gly Gly
    2210                2215                2220
Met Ala Gly His Gly Gln Phe Gln Gln Pro Gln Gly Pro Gly Gly Tyr
2225                2230                2235                2240
Pro Pro Ala Met Gln Gln Gln Gln Arg Met Gln Gln His Leu Pro Leu
                2245                2250                2255
Gln Gly Ser Ser Met Gly Gln Met Ala Ala Gln Met Gly Gln Leu Gly
            2260                2265                2270
Gln Met Gly Gln Pro Gly Leu Gly Ala Asp Ser Thr Pro Asn Ile Gln
        2275                2280                2285
Gln Ala Leu Gln Gln Arg Ile Leu Gln Gln Gln Gln Met Lys Gln Gln
    2290                2295                2300
Ile Gly Ser Pro Gly Gln Pro Asn Pro Met Ser Pro Gln Gln His Met
2305                2310                2315                2320
Leu Ser Gly Gln Pro Gln Ala Ser His Leu Pro Gly Gln Gln Ile Ala
                2325                2330                2335
Thr Ser Leu Ser Asn Gln Val Arg Ser Pro Ala Pro Val Gln Ser Pro
            2340                2345                2350
Arg Pro Gln Ser Gln Pro Pro His Ser Ser Pro Ser Pro Arg Ile Gln
        2355                2360                2365
Pro Gln Pro Ser Pro His His Val Ser Pro Gln Thr Gly Ser Pro His
    2370                2375                2380
Pro Gly Leu Ala Val Thr Met Ala Ser Ser Ile Asp Gln Gly His Leu
2385                2390                2395                2400
Gly Asn Pro Glu Gln Ser Ala Met Leu Pro Gln Leu Asn Thr Pro Ser
                2405                2410                2415
Arg Ser Ala Leu Ser Ser Glu Leu Ser Leu Val Gly Asp Thr Thr Gly
            2420                2425                2430
Asp Thr Leu Glu Lys Phe Val Glu Gly Leu
        2435                2440

<210> 648
<211> 963
<212> PRT
<213> Homo sapiens

<400> 648
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro
 1               5                  10                  15
Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp
            20                  25                  30
Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile
        35                  40                  45
Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu
    50                  55                  60
Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln
65                  70                  75                  80
Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly
                85                  90                  95
Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser
            100                 105                 110
Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln
        115                 120                 125
Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn
    130                 135                 140
Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln
145                 150                 155                 160
Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly
                165                 170                 175
Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met
            180                 185                 190
Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro
        195                 200                 205
Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln
    210                 215                 220
Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln
225                 230                 235                 240
Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro
                245                 250                 255
Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu
            260                 265                 270
Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala
        275                 280                 285
Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln
    290                 295                 300
Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala
305                 310                 315                 320
Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys
                325                 330                 335
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
            340                 345                 350
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His
        355                 360                 365
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser
    370                 375                 380
Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
385                 390                 395                 400
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
                405                 410                 415
Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly
            420                 425                 430
Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln
        435                 440                 445
Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile
    450                 455                 460
Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met
465                 470                 475                 480
Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro
                485                 490                 495
Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser
            500                 505                 510
Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu
        515                 520                 525
Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met
    530                 535                 540
Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala
545                 550                 555                 560
Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr
                565                 570                 575
Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe
            580                 585                 590
Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu
        595                 600                 605
Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn
    610                 615                 620
Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile
625                 630                 635                 640
Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn
                645                 650                 655
Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly
            660                 665                 670
Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu
        675                 680                 685
Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro
    690                 695                 700
Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met
705                 710                 715                 720
Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His
                725                 730                 735
Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly
            740                 745                 750
Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr
        755                 760                 765
Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro
    770                 775                 780
Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser
785                 790                 795                 800
Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His
                805                 810                 815
Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro
            820                 825                 830
Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser
        835                 840                 845
Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro
    850                 855                 860
Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro
865                 870                 875                 880
Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln
                885                 890                 895
Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln
            900                 905                 910
Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr
        915                 920                 925
Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala
    930                 935                 940
Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr
945                 950                 955                 960
Glu Val Asn


<210> 649
<211> 754
<212> PRT
<213> Homo sapiens

<400> 649
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750
Phe Ile


<210> 650
<211> 1408
<212> PRT
<213> Homo sapiens

<400> 650
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750
Phe Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu
        755                 760                 765
Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn
    770                 775                 780
Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala
785                 790                 795                 800
Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile
                805                 810                 815
Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro
            820                 825                 830
Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr
        835                 840                 845
Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys
    850                 855                 860
Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly
865                 870                 875                 880
Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly
                885                 890                 895
Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys
            900                 905                 910
Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu
        915                 920                 925
Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln
    930                 935                 940
Pro Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser
945                 950                 955                 960
Thr Ala Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg
                965                 970                 975
Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg
            980                 985                 990
Val His Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser
        995                 1000                1005
Pro Thr Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr
    1010                1015                1020
Phe Pro Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg
1025                1030                1035                1040
Gln Val Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly
                1045                1050                1055
Asp Ser Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp
            1060                1065                1070
Leu Ser Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val
        1075                1080                1085
Ile Gly Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg
    1090                1095                1100
Gly His Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly
1105                1110                1115                1120
Lys Lys Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile
                1125                1130                1135
Gly Glu Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe
            1140                1145                1150
Ser His Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu
        1155                1160                1165
Gly Ser Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg
    1170                1175                1180
Asn Phe Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile
1185                1190                1195                1200
Gly Phe Gly Leu Gln Val Ala Lys Ala Met Lys Tyr Leu Ala Ser Lys
                1205                1210                1215
Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu
            1220                1225                1230
Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr
        1235                1240                1245
Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro
    1250                1255                1260
Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr
1265                1270                1275                1280
Lys Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Leu Met Thr
                1285                1290                1295
Arg Gly Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val
            1300                1305                1310
Tyr Leu Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp
        1315                1320                1325
Pro Leu Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met
    1330                1335                1340
Arg Pro Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser
1345                1350                1355                1360
Thr Phe Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn
                1365                1370                1375
Val Lys Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn
            1380                1385                1390
Ala Asp Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
        1395                1400                1405

<210> 651
<211> 1390
<212> PRT
<213> Homo sapiens

<400> 651
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn
        755                 760                 765
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg
    770                 775                 780
Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys
785                 790                 795                 800
Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys
                805                 810                 815
Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp
            820                 825                 830
Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val
        835                 840                 845
Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp
    850                 855                 860
Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys
865                 870                 875                 880
Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val
                885                 890                 895
Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys
            900                 905                 910
Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp
        915                 920                 925
Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala
    930                 935                 940
Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln
945                 950                 955                 960
Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His
                965                 970                 975
Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr
            980                 985                 990
Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro
        995                 1000                1005
Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val
    1010                1015                1020
Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser
1025                1030                1035                1040
Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser
                1045                1050                1055
Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly
            1060                1065                1070
Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg Gly His
        1075                1080                1085
Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly Lys Lys
    1090                1095                1100
Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu
1105                1110                1115                1120
Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His
                1125                1130                1135
Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly Ser
            1140                1145                1150
Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn Phe
        1155                1160                1165
Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly Phe
    1170                1175                1180
Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe
1185                1190                1195                1200
Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys Phe
                1205                1210                1215
Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr Asp Lys
            1220                1225                1230
Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro Val Lys
        1235                1240                1245
Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys Ser
    1250                1255                1260
Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Leu Met Thr Arg Gly
1265                1270                1275                1280
Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val Tyr Leu
                1285                1290                1295
Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Pro Leu
            1300                1305                1310
Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg Pro
        1315                1320                1325
Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser Thr Phe
    1330                1335                1340
Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn Val Lys
1345                1350                1355                1360
Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp
                1365                1370                1375
Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
            1380                1385                1390

<210> 652
<211> 1408
<212> PRT
<213> Homo sapiens

<400> 652
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750
Phe Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu
        755                 760                 765
Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn
    770                 775                 780
Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala
785                 790                 795                 800
Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile
                805                 810                 815
Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro
            820                 825                 830
Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr
        835                 840                 845
Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys
    850                 855                 860
Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly
865                 870                 875                 880
Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly
                885                 890                 895
Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys
            900                 905                 910
Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu
        915                 920                 925
Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln
    930                 935                 940
Pro Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser
945                 950                 955                 960
Thr Ala Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg
                965                 970                 975
Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg
            980                 985                 990
Val His Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser
        995                 1000                1005
Pro Thr Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr
    1010                1015                1020
Phe Pro Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg
1025                1030                1035                1040
Gln Val Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly
                1045                1050                1055
Asp Ser Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp
            1060                1065                1070
Leu Ser Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val
        1075                1080                1085
Ile Gly Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg
    1090                1095                1100
Gly His Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly
1105                1110                1115                1120
Lys Lys Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile
                1125                1130                1135
Gly Glu Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe
            1140                1145                1150
Ser His Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu
        1155                1160                1165
Gly Ser Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg
    1170                1175                1180
Asn Phe Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile
1185                1190                1195                1200
Gly Phe Gly Leu Gln Val Ala Lys Ala Met Lys Tyr Leu Ala Ser Lys
                1205                1210                1215
Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu
            1220                1225                1230
Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr
        1235                1240                1245
Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro
    1250                1255                1260
Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr
1265                1270                1275                1280
Lys Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Leu Met Thr
                1285                1290                1295
Arg Gly Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val
            1300                1305                1310
Tyr Leu Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp
        1315                1320                1325
Pro Leu Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met
    1330                1335                1340
Arg Pro Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser
1345                1350                1355                1360
Thr Phe Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn
                1365                1370                1375
Val Lys Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn
            1380                1385                1390
Ala Asp Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
        1395                1400                1405

<210> 653
<211> 1390
<212> PRT
<213> Homo sapiens

<400> 653
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn
        755                 760                 765
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg
    770                 775                 780
Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys
785                 790                 795                 800
Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys
                805                 810                 815
Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp
            820                 825                 830
Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val
        835                 840                 845
Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp
    850                 855                 860
Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys
865                 870                 875                 880
Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val
                885                 890                 895
Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys
            900                 905                 910
Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp
        915                 920                 925
Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala
    930                 935                 940
Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln
945                 950                 955                 960
Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His
                965                 970                 975
Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr
            980                 985                 990
Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro
        995                 1000                1005
Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val
    1010                1015                1020
Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser
1025                1030                1035                1040
Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser
                1045                1050                1055
Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly
            1060                1065                1070
Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg Gly His
        1075                1080                1085
Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly Lys Lys
    1090                1095                1100
Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu
1105                1110                1115                1120
Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His
                1125                1130                1135
Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly Ser
            1140                1145                1150
Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn Phe
        1155                1160                1165
Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly Phe
    1170                1175                1180
Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe
1185                1190                1195                1200
Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys Phe
                1205                1210                1215
Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr Asp Lys
            1220                1225                1230
Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro Val Lys
        1235                1240                1245
Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys Ser
    1250                1255                1260
Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Leu Met Thr Arg Gly
1265                1270                1275                1280
Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val Tyr Leu
                1285                1290                1295
Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Pro Leu
            1300                1305                1310
Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg Pro
        1315                1320                1325
Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser Thr Phe
    1330                1335                1340
Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn Val Lys
1345                1350                1355                1360
Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp
                1365                1370                1375
Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
            1380                1385                1390

<210> 654
<211> 1072
<212> PRT
<213> Homo sapiens

<400> 654
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685
Ser Ser Ser Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975
Ser Glu Glu Met Tyr Cys Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055
Ile Glu Asn Lys Leu Tyr Gly Arg Ile Ser His Ala Phe Thr Arg Phe
            1060                1065                1070

<210> 655
<211> 860
<212> PRT
<213> Homo sapiens

<400> 655
Met Val Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro
 1               5                  10                  15
Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys
            20                  25                  30
Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp
        35                  40                  45
Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu
    50                  55                  60
Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp
65                  70                  75                  80
Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr
                85                  90                  95
Val His Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu
            100                 105                 110
Asn Arg Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln
        115                 120                 125
Gly Pro Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu
    130                 135                 140
Pro Val Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg
145                 150                 155                 160
Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys
                165                 170                 175
Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly
            180                 185                 190
Ala Asn Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser
        195                 200                 205
Gly Ile Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys
    210                 215                 220
Ala Glu Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg
225                 230                 235                 240
Gln Ala Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala
                245                 250                 255
Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu
            260                 265                 270
Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu
        275                 280                 285
Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys
    290                 295                 300
Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu
305                 310                 315                 320
Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile
                325                 330                 335
Val Gly Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr
            340                 345                 350
Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro
        355                 360                 365
Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile
    370                 375                 380
Ala Ala Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala
385                 390                 395                 400
Phe Cys Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser
                405                 410                 415
Ser Ala Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser
            420                 425                 430
Tyr Ser Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn
        435                 440                 445
Gln Val Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu
    450                 455                 460
Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu
465                 470                 475                 480
Phe Gly Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala
                485                 490                 495
Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro
            500                 505                 510
Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val
        515                 520                 525
Asn His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly
    530                 535                 540
Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly
545                 550                 555                 560
Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly
                565                 570                 575
Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu
            580                 585                 590
Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met
        595                 600                 605
Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg
    610                 615                 620
Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly
625                 630                 635                 640
Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln
                645                 650                 655
Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His
            660                 665                 670
Ile Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp
        675                 680                 685
Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu
    690                 695                 700
Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp
705                 710                 715                 720
Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln
                725                 730                 735
Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu
            740                 745                 750
Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr
        755                 760                 765
Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr
    770                 775                 780
Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser
785                 790                 795                 800
Thr Trp Ile Glu Asn Lys Leu Tyr Gly Met Ser Asp Pro Asn Trp Pro
                805                 810                 815
Gly Glu Ser Pro Val Pro Leu Thr Arg Ala Asp Gly Thr Asn Thr Gly
            820                 825                 830
Phe Pro Arg Tyr Pro Asn Asp Ser Val Tyr Ala Asn Trp Met Leu Ser
        835                 840                 845
Pro Ser Ala Ala Lys Leu Met Asp Thr Phe Asp Ser
    850                 855                 860

<210> 656
<211> 1091
<212> PRT
<213> Homo sapiens

<400> 656
Val Ala Leu Gly Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu
 1               5                  10                  15
Tyr Val Asp Gln Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu
            20                  25                  30
Arg Asp Ala Pro Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu
        35                  40                  45
Tyr Gly Thr Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile
    50                  55                  60
Gln Glu Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His Ser
65                  70                  75                  80
Ser Trp Glu Lys Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu Thr
                85                  90                  95
Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly Glu
            100                 105                 110
Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn Thr
        115                 120                 125
Ser Phe Pro Ala Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe Pro
    130                 135                 140
Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly Thr
145                 150                 155                 160
Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn Ile
                165                 170                 175
Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg Cys
            180                 185                 190
Ala Pro Asp Ser Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg Glu
        195                 200                 205
Gln Arg Glu Lys Tyr Glu Leu Val Ala Val Cys Thr Val His Ala Gly
    210                 215                 220
Ala Arg Glu Glu Val Val Met Val Pro Phe Pro Val Thr Val Tyr Asp
225                 230                 235                 240
Glu Asp Asp Ser Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala Ser
                245                 250                 255
Ala Val Val Glu Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu
            260                 265                 270
Arg Val Phe Asp Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg
        275                 280                 285
Arg Tyr Thr Ser Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr
    290                 295                 300
Phe Arg Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly
305                 310                 315                 320
Ser Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg
                325                 330                 335
Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu Val
            340                 345                 350
Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu His
        355                 360                 365
Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro Ser Thr Tyr
    370                 375                 380
Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys
385                 390                 395                 400
Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr
                405                 410                 415
Lys Leu His Ser Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val Thr
            420                 425                 430
Ser Ala Glu Asp Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys Ala
        435                 440                 445
Leu Arg Arg Pro Lys Cys Ala Glu Leu His Tyr Met Val Val Ala Thr
    450                 455                 460
Asp Gln Gln Thr Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr Val
465                 470                 475                 480
Glu Gly Ser Tyr Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala
                485                 490                 495
Val Ser Lys Arg Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser
            500                 505                 510
Pro Thr Gly Arg Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr
        515                 520                 525
Arg Asn Phe Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly
    530                 535                 540
His Cys Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp
545                 550                 555                 560
Cys Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg
                565                 570                 575
Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu
            580                 585                 590
Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu
        595                 600                 605
Leu Cys Arg Thr Val Ile Ala Ala Ala Val Leu Phe Ser Phe Ile Val
    610                 615                 620
Ser Val Leu Leu Ser Ala Phe Cys Ile His Cys Tyr His Lys Phe Ala
625                 630                 635                 640
His Lys Pro Pro Ile Ser Ser Ala Glu Met Thr Phe Arg Arg Pro Ala
                645                 650                 655
Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser Gly Ala Arg Arg Pro Ser
            660                 665                 670
Leu Asp Ser Met Glu Asn Gln Val Ser Val Asp Ala Phe Lys Ile Leu
        675                 680                 685
Glu Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys
    690                 695                 700
Thr Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr Ala Phe
705                 710                 715                 720
His Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys Met Leu
                725                 730                 735
Lys Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe
            740                 745                 750
Asn Val Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu Tyr Gly
        755                 760                 765
Ala Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys
    770                 775                 780
Tyr Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro
785                 790                 795                 800
Gly Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His
                805                 810                 815
Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala Trp
            820                 825                 830
Gln Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu Val His
        835                 840                 845
Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg Lys Met
    850                 855                 860
Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser
865                 870                 875                 880
Tyr Val Lys Arg Ser Gln Val Gly Arg Ile Pro Val Lys Trp Met Ala
                885                 890                 895
Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val Trp
            900                 905                 910
Ser Phe Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn Pro
        915                 920                 925
Tyr Pro Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly
    930                 935                 940
His Arg Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu
945                 950                 955                 960
Met Leu Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe Ala
                965                 970                 975
Asp Ile Ser Lys Asp Leu Glu Lys Met Met Val Lys Arg Arg Asp Tyr
            980                 985                 990
Leu Asp Leu Ala Ala Ser Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp
        995                 1000                1005
Gly Leu Ser Glu Glu Glu Thr Pro Leu Val Asp Cys Asn Asn Ala Pro
    1010                1015                1020
Leu Pro Arg Ala Leu Pro Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly
1025                1030                1035                1040
Met Ser Asp Pro Asn Trp Pro Gly Glu Ser Pro Val Pro Leu Thr Arg
                1045                1050                1055
Ala Asp Gly Thr Asn Thr Gly Phe Pro Arg Tyr Pro Asn Asp Ser Val
            1060                1065                1070
Tyr Ala Asn Trp Met Leu Ser Pro Ser Ala Ala Lys Leu Met Asp Thr
        1075                1080                1085
Phe Asp Ser
    1090

<210> 657
<211> 85
<212> PRT
<213> Homo sapiens

<400> 657
Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala Ala Val Leu
 1               5                  10                  15
Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys Ile His Cys
            20                  25                  30
Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala Glu Met Thr
        35                  40                  45
Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser Ser
    50                  55                  60
Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val Ser Val Asp
65                  70                  75                  80
Ala Phe Lys Ile Leu
                85

<210> 658
<211> 1106
<212> PRT
<213> Homo sapiens

<400> 658
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055
Ile Glu Asn Lys Leu Tyr Asp Ala Gln His Ser Ser Ser Leu Val Gly
            1060                1065                1070
Ala Ala Phe Gly Lys Ser Gln Gln Leu Phe Trp Leu Cys Cys Gln His
        1075                1080                1085
Cys Asn Phe Ala Glu Lys Ser Arg Ile Thr Lys Thr Leu Pro Ala Leu
    1090                1095                1100
Gln Thr
1105

<210> 659
<211> 1072
<212> PRT
<213> Homo sapiens

<400> 659
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055
Ile Glu Asn Lys Leu Tyr Gly Arg Ile Ser His Ala Phe Thr Arg Phe
            1060                1065                1070

<210> 660
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 660
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055
Ile Glu Asn Lys Leu Tyr Gly Met Ser Asp Pro Asn Trp Pro Gly Glu
            1060                1065                1070
Ser Pro Val Pro Leu Thr Arg Ala Asp Gly Thr Asn Thr Gly Phe Pro
        1075                1080                1085
Arg Tyr Pro Asn Asp Ser Val Tyr Ala Asn Trp Met Leu Ser Pro Ser
    1090                1095                1100
Ala Ala Lys Leu Met Asp Thr Phe Asp Ser
1105                1110

<210> 661
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 661
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055
Ile Glu Asn Lys Leu Tyr Gly Met Ser Asp Pro Asn Trp Pro Gly Glu
            1060                1065                1070
Ser Pro Val Pro Leu Thr Arg Ala Asp Gly Thr Asn Thr Gly Phe Pro
        1075                1080                1085
Arg Tyr Pro Asn Asp Ser Val Tyr Ala Asn Trp Met Leu Ser Pro Ser
    1090                1095                1100
Ala Ala Lys Leu Met Asp Thr Phe Asp Ser
1105                1110

<210> 662
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 662
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055
Ile Glu Asn Lys Leu Tyr Gly Met Ser Asp Pro Asn Trp Pro Gly Glu
            1060                1065                1070
Ser Pro Val Pro Leu Thr Arg Ala Asp Gly Thr Asn Thr Gly Phe Pro
        1075                1080                1085
Arg Tyr Pro Asn Asp Ser Val Tyr Ala Asn Trp Met Leu Ser Pro Ser
    1090                1095                1100
Ala Ala Lys Leu Met Asp Thr Phe Asp Ser
1105                1110

<210> 663
<211> 1072
<212> PRT
<213> Homo sapiens

<400> 663
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685
Ser Ser Ser Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975
Ser Glu Glu Met Tyr Cys Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055
Ile Glu Asn Lys Leu Tyr Gly Arg Ile Ser His Ala Phe Thr Arg Phe
            1060                1065                1070

<210> 664
<211> 1089
<212> PRT
<213> Homo sapiens

<400> 664
Ala Leu Gly Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu Tyr
 1               5                  10                  15
Val Asp Gln Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu Arg
            20                  25                  30
Asp Ala Pro Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu Tyr
        35                  40                  45
Gly Thr Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile Gln
    50                  55                  60
Glu Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His Ser Ser
65                  70                  75                  80
Trp Glu Lys Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu Thr Val
                85                  90                  95
Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly Glu Cys
            100                 105                 110
Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn Thr Ser
        115                 120                 125
Phe Pro Ala Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe Pro Glu
    130                 135                 140
Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly Thr Phe
145                 150                 155                 160
His Gln Phe Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn Ile Ser
                165                 170                 175
Val Ala Tyr Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg Cys Ala
            180                 185                 190
Pro Asp Ser Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg Glu Gln
        195                 200                 205
Arg Glu Lys Tyr Glu Leu Val Ala Val Cys Thr Val His Ala Gly Ala
    210                 215                 220
Arg Glu Glu Val Val Met Val Pro Phe Pro Val Thr Val Tyr Asp Glu
225                 230                 235                 240
Asp Asp Ser Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala
                245                 250                 255
Val Val Glu Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg
            260                 265                 270
Val Phe Asp Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg
        275                 280                 285
Tyr Thr Ser Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr Phe
    290                 295                 300
Arg Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser
305                 310                 315                 320
Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg Asn
                325                 330                 335
Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu Val Asn
            340                 345                 350
Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu His Phe
        355                 360                 365
Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro Ser Thr Tyr Ser
    370                 375                 380
Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys Val
385                 390                 395                 400
Cys Val Glu Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr Lys
                405                 410                 415
Leu His Ser Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val Thr Ser
            420                 425                 430
Ala Glu Asp Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys Ala Leu
        435                 440                 445
Arg Arg Pro Lys Cys Ala Glu Leu His Tyr Met Val Val Ala Thr Asp
    450                 455                 460
Gln Gln Thr Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr Val Glu
465                 470                 475                 480
Gly Ser Tyr Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val
                485                 490                 495
Ser Lys Arg Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro
            500                 505                 510
Thr Gly Arg Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg
        515                 520                 525
Asn Phe Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His
    530                 535                 540
Cys Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys
545                 550                 555                 560
Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg Gly
                565                 570                 575
Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu Lys
            580                 585                 590
Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu Leu
        595                 600                 605
Cys Arg Thr Val Ile Ala Ala Ala Val Leu Phe Ser Phe Ile Val Ser
    610                 615                 620
Val Leu Leu Ser Ala Phe Cys Ile His Cys Tyr His Lys Phe Ala His
625                 630                 635                 640
Lys Pro Pro Ile Ser Ser Ala Glu Met Thr Phe Arg Arg Pro Ala Gln
                645                 650                 655
Ala Phe Pro Val Ser Tyr Ser Ser Ser Gly Ala Arg Arg Pro Ser Leu
            660                 665                 670
Asp Ser Met Glu Asn Gln Val Ser Val Asp Ala Phe Lys Ile Leu Glu
        675                 680                 685
Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr
    690                 695                 700
Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr Ala Phe His
705                 710                 715                 720
Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys
                725                 730                 735
Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn
            740                 745                 750
Val Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu Tyr Gly Ala
        755                 760                 765
Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr
    770                 775                 780
Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly
785                 790                 795                 800
Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro
                805                 810                 815
Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln
            820                 825                 830
Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg
        835                 840                 845
Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys
    850                 855                 860
Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr
865                 870                 875                 880
Val Lys Arg Ser Gln Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu
                885                 890                 895
Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe
            900                 905                 910
Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro
        915                 920                 925
Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg
    930                 935                 940
Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu
945                 950                 955                 960
Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile
                965                 970                 975
Ser Lys Asp Leu Glu Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp
            980                 985                 990
Leu Ala Ala Ser Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu
        995                 1000                1005
Ser Glu Glu Glu Thr Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro
    1010                1015                1020
Arg Ala Leu Pro Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly Met Ser
1025                1030                1035                1040
Asp Pro Asn Trp Pro Gly Glu Ser Pro Val Pro Leu Thr Arg Ala Asp
                1045                1050                1055
Gly Thr Asn Thr Gly Phe Pro Arg Tyr Pro Asn Asp Ser Val Tyr Ala
            1060                1065                1070
Asn Trp Met Leu Ser Pro Ser Ala Ala Lys Leu Met Asp Thr Phe Asp
        1075                1080                1085
Ser


<210> 665
<211> 1091
<212> PRT
<213> Homo sapiens

<400> 665
Val Ala Leu Gly Leu Tyr Phe Ser Arg Asp Ala Tyr Trp Glu Lys Leu
 1               5                  10                  15
Tyr Val Asp Gln Ala Ala Gly Thr Pro Leu Leu Tyr Val His Ala Leu
            20                  25                  30
Arg Asp Ala Pro Glu Glu Val Pro Ser Phe Arg Leu Gly Gln His Leu
        35                  40                  45
Tyr Gly Thr Tyr Arg Thr Arg Leu His Glu Asn Asn Trp Ile Cys Ile
    50                  55                  60
Gln Glu Asp Thr Gly Leu Leu Tyr Leu Asn Arg Ser Leu Asp His Ser
65                  70                  75                  80
Ser Trp Glu Lys Leu Ser Val Arg Asn Arg Gly Phe Pro Leu Leu Thr
                85                  90                  95
Val Tyr Leu Lys Val Phe Leu Ser Pro Thr Ser Leu Arg Glu Gly Glu
            100                 105                 110
Cys Gln Trp Pro Gly Cys Ala Arg Val Tyr Phe Ser Phe Phe Asn Thr
        115                 120                 125
Ser Phe Pro Ala Cys Ser Ser Leu Lys Pro Arg Glu Leu Cys Phe Pro
    130                 135                 140
Glu Thr Arg Pro Ser Phe Arg Ile Arg Glu Asn Arg Pro Pro Gly Thr
145                 150                 155                 160
Phe His Gln Phe Arg Leu Leu Pro Val Gln Phe Leu Cys Pro Asn Ile
                165                 170                 175
Ser Val Ala Tyr Arg Leu Leu Glu Gly Glu Gly Leu Pro Phe Arg Cys
            180                 185                 190
Ala Pro Asp Ser Leu Glu Val Ser Thr Arg Trp Ala Leu Asp Arg Glu
        195                 200                 205
Gln Arg Glu Lys Tyr Glu Leu Val Ala Val Cys Thr Val His Ala Gly
    210                 215                 220
Ala Arg Glu Glu Val Val Met Val Pro Phe Pro Val Thr Val Tyr Asp
225                 230                 235                 240
Glu Asp Asp Ser Ala Pro Thr Phe Pro Ala Gly Val Asp Thr Ala Ser
                245                 250                 255
Ala Val Val Glu Phe Lys Arg Lys Glu Asp Thr Val Val Ala Thr Leu
            260                 265                 270
Arg Val Phe Asp Ala Asp Val Val Pro Ala Ser Gly Glu Leu Val Arg
        275                 280                 285
Arg Tyr Thr Ser Thr Leu Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr
    290                 295                 300
Phe Arg Val Glu His Trp Pro Asn Glu Thr Ser Val Gln Ala Asn Gly
305                 310                 315                 320
Ser Phe Val Arg Ala Thr Val His Asp Tyr Arg Leu Val Leu Asn Arg
                325                 330                 335
Asn Leu Ser Ile Ser Glu Asn Arg Thr Met Gln Leu Ala Val Leu Val
            340                 345                 350
Asn Asp Ser Asp Phe Gln Gly Pro Gly Ala Gly Val Leu Leu Leu His
        355                 360                 365
Phe Asn Val Ser Val Leu Pro Val Ser Leu His Leu Pro Ser Thr Tyr
    370                 375                 380
Ser Leu Ser Val Ser Arg Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys
385                 390                 395                 400
Val Cys Val Glu Asn Cys Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr
                405                 410                 415
Lys Leu His Ser Ser Gly Ala Asn Cys Ser Thr Leu Gly Val Val Thr
            420                 425                 430
Ser Ala Glu Asp Thr Ser Gly Ile Leu Phe Val Asn Asp Thr Lys Ala
        435                 440                 445
Leu Arg Arg Pro Lys Cys Ala Glu Leu His Tyr Met Val Val Ala Thr
    450                 455                 460
Asp Gln Gln Thr Ser Arg Gln Ala Gln Ala Gln Leu Leu Val Thr Val
465                 470                 475                 480
Glu Gly Ser Tyr Val Ala Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala
                485                 490                 495
Val Ser Lys Arg Arg Leu Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser
            500                 505                 510
Pro Thr Gly Arg Cys Glu Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr
        515                 520                 525
Arg Asn Phe Ser Thr Cys Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly
    530                 535                 540
His Cys Asp Val Val Glu Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp
545                 550                 555                 560
Cys Leu Arg Gly Ser Ile Val Gly Gly His Glu Pro Gly Glu Pro Arg
                565                 570                 575
Gly Ile Lys Ala Gly Tyr Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu
            580                 585                 590
Lys Cys Phe Cys Glu Pro Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu
        595                 600                 605
Leu Cys Arg Thr Val Ile Ala Ala Ala Val Leu Phe Ser Phe Ile Val
    610                 615                 620
Ser Val Leu Leu Ser Ala Phe Cys Ile His Cys Tyr His Lys Phe Ala
625                 630                 635                 640
His Lys Pro Pro Ile Ser Ser Ala Glu Met Thr Phe Arg Arg Pro Ala
                645                 650                 655
Gln Ala Phe Pro Val Ser Tyr Ser Ser Ser Gly Ala Arg Arg Pro Ser
            660                 665                 670
Leu Asp Ser Met Glu Asn Gln Val Ser Val Asp Ala Phe Lys Ile Leu
        675                 680                 685
Glu Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys
    690                 695                 700
Thr Leu Gly Glu Gly Glu Phe Gly Lys Val Val Lys Ala Thr Ala Phe
705                 710                 715                 720
His Leu Lys Gly Arg Ala Gly Tyr Thr Thr Val Ala Val Lys Met Leu
                725                 730                 735
Lys Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe
            740                 745                 750
Asn Val Leu Lys Gln Val Asn His Pro His Val Ile Lys Leu Tyr Gly
        755                 760                 765
Ala Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys
    770                 775                 780
Tyr Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro
785                 790                 795                 800
Gly Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His
                805                 810                 815
Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala Trp
            820                 825                 830
Gln Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu Met Lys Leu Val His
        835                 840                 845
Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala Glu Gly Arg Lys Met
    850                 855                 860
Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser
865                 870                 875                 880
Tyr Val Lys Arg Ser Gln Val Gly Arg Ile Pro Val Lys Trp Met Ala
                885                 890                 895
Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr Gln Ser Asp Val Trp
            900                 905                 910
Ser Phe Gly Val Leu Leu Trp Glu Ile Val Thr Leu Gly Gly Asn Pro
        915                 920                 925
Tyr Pro Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly
    930                 935                 940
His Arg Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu
945                 950                 955                 960
Met Leu Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg Pro Val Phe Ala
                965                 970                 975
Asp Ile Ser Lys Asp Leu Glu Lys Met Met Val Lys Arg Arg Asp Tyr
            980                 985                 990
Leu Asp Leu Ala Ala Ser Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp
        995                 1000                1005
Gly Leu Ser Glu Glu Glu Thr Pro Leu Val Asp Cys Asn Asn Ala Pro
    1010                1015                1020
Leu Pro Arg Ala Leu Pro Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly
1025                1030                1035                1040
Met Ser Asp Pro Asn Trp Pro Gly Glu Ser Pro Val Pro Leu Thr Arg
                1045                1050                1055
Ala Asp Gly Thr Asn Thr Gly Phe Pro Arg Tyr Pro Asn Asp Ser Val
            1060                1065                1070
Tyr Ala Asn Trp Met Leu Ser Pro Ser Ala Ala Lys Leu Met Asp Thr
        1075                1080                1085
Phe Asp Ser
    1090

<210> 666
<211> 1722
<212> PRT
<213> Homo sapiens

<400> 666
Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met
 1               5                  10                  15
Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala
            20                  25                  30
Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys
        35                  40                  45
Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp
    50                  55                  60
Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser
65                  70                  75                  80
Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg
                85                  90                  95
Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His
            100                 105                 110
His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly
        115                 120                 125
His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly
    130                 135                 140
Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg
145                 150                 155                 160
Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp
                165                 170                 175
Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro
            180                 185                 190
Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile
        195                 200                 205
Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu
    210                 215                 220
Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp
225                 230                 235                 240
Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser
                245                 250                 255
Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile
            260                 265                 270
Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly
        275                 280                 285
Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro
    290                 295                 300
Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met
305                 310                 315                 320
Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu
                325                 330                 335
Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp
            340                 345                 350
Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn
        355                 360                 365
Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys
    370                 375                 380
Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His
385                 390                 395                 400
Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp
                405                 410                 415
Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr
            420                 425                 430
Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp
        435                 440                 445
Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser
    450                 455                 460
Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys
465                 470                 475                 480
Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser
                485                 490                 495
Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu
            500                 505                 510
Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys
        515                 520                 525
Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu
    530                 535                 540
Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu
545                 550                 555                 560
Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly
                565                 570                 575
Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala
            580                 585                 590
Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys
        595                 600                 605
Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys
    610                 615                 620
Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp
625                 630                 635                 640
Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys
                645                 650                 655
Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu
            660                 665                 670
Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe
        675                 680                 685
Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln
    690                 695                 700
Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro
705                 710                 715                 720
Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr
                725                 730                 735
Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys
            740                 745                 750
Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe
        755                 760                 765
Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr
    770                 775                 780
Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr
785                 790                 795                 800
Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu
                805                 810                 815
Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn
            820                 825                 830
Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala
        835                 840                 845
Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala
    850                 855                 860
Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp
865                 870                 875                 880
Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe
                885                 890                 895
Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp
            900                 905                 910
Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe
        915                 920                 925
Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp
    930                 935                 940
Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn
945                 950                 955                 960
Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala
                965                 970                 975
Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser
            980                 985                 990
Gln Ile Glu Gln Asp Phe Ile Thr Ser Leu Leu Pro Asp Met Glu Ala
        995                 1000                1005
Thr Leu Trp Ile Gly Leu Arg Trp Thr Ala Tyr Glu Lys Ile Asn Lys
    1010                1015                1020
Trp Thr Asp Asn Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu
1025                1030                1035                1040
Val Ser Gly Arg Leu Arg Ile Pro Glu Asn Phe Phe Glu Glu Glu Ser
                1045                1050                1055
Arg Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys Ser Pro Phe Thr
            1060                1065                1070
Gly Thr Trp Asn Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu
        1075                1080                1085
Cys Gln Lys Tyr Ser Glu Val Lys Ser Arg Gln Thr Leu Gln Asn Ala
    1090                1095                1100
Ser Glu Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile Pro Lys
1105                1110                1115                1120
Thr Leu Thr Trp His Ser Ala Lys Arg Glu Cys Leu Lys Ser Asn Met
                1125                1130                1135
Gln Leu Val Ser Ile Thr Asp Pro Tyr Gln Gln Ala Phe Leu Ser Val
            1140                1145                1150
Gln Ala Leu Leu His Asn Ser Ser Leu Trp Ile Gly Leu Phe Ser Gln
        1155                1160                1165
Asp Asp Glu Leu Asn Phe Gly Trp Ser Asp Gly Lys Arg Leu His Phe
    1170                1175                1180
Ser Arg Trp Ala Glu Thr Asn Gly Gln Leu Glu Asp Cys Val Val Leu
1185                1190                1195                1200
Asp Thr Asp Gly Phe Trp Lys Thr Val Asp Cys Asn Asp Asn Gln Pro
                1205                1210                1215
Gly Ala Ile Cys Tyr Tyr Ser Gly Asn Glu Thr Glu Lys Glu Val Lys
            1220                1225                1230
Pro Val Asp Ser Val Lys Cys Pro Ser Pro Val Leu Asn Thr Pro Trp
        1235                1240                1245
Ile Pro Phe Gln Asn Cys Cys Tyr Asn Phe Ile Ile Thr Lys Asn Arg
    1250                1255                1260
His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys Cys Gln Lys Leu
1265                1270                1275                1280
Asn Pro Lys Ser His Ile Leu Ser Ile Arg Asp Glu Lys Glu Asn Asn
                1285                1290                1295
Phe Val Leu Glu Gln Leu Leu Tyr Phe Asn Tyr Met Ala Ser Trp Val
            1300                1305                1310
Met Leu Gly Ile Thr Tyr Arg Asn Asn Ser Leu Met Trp Phe Asp Lys
        1315                1320                1325
Thr Pro Leu Ser Tyr Thr His Trp Arg Ala Gly Arg Pro Thr Ile Lys
    1330                1335                1340
Asn Glu Lys Phe Leu Ala Gly Leu Ser Thr Asp Gly Phe Trp Asp Ile
1345                1350                1355                1360
Gln Thr Phe Lys Val Ile Glu Glu Ala Val Tyr Phe His Gln His Ser
                1365                1370                1375
Ile Leu Ala Cys Lys Ile Glu Met Val Asp Tyr Lys Glu Glu His Asn
            1380                1385                1390
Thr Thr Leu Pro Gln Phe Met Pro Tyr Glu Asp Gly Ile Tyr Ser Val
        1395                1400                1405
Ile Gln Lys Lys Val Thr Trp Tyr Glu Ala Leu Asn Met Cys Ser Gln
    1410                1415                1420
Ser Gly Gly His Leu Ala Ser Val His Asn Gln Asn Gly Gln Leu Phe
1425                1430                1435                1440
Leu Glu Asp Ile Val Lys Arg Asp Gly Phe Pro Leu Trp Val Gly Leu
                1445                1450                1455
Ser Ser His Asp Gly Ser Glu Ser Ser Phe Glu Trp Ser Asp Gly Ser
            1460                1465                1470
Thr Phe Asp Tyr Ile Pro Trp Lys Gly Gln Thr Ser Pro Gly Asn Cys
        1475                1480                1485
Val Leu Leu Asp Pro Lys Gly Thr Trp Lys His Glu Lys Cys Asn Ser
    1490                1495                1500
Val Lys Asp Gly Ala Ile Cys Tyr Lys Pro Thr Lys Ser Lys Lys Leu
1505                1510                1515                1520
Ser Arg Leu Thr Tyr Ser Ser Arg Cys Pro Ala Ala Lys Glu Asn Gly
                1525                1530                1535
Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp Gln Ala
            1540                1545                1550
Leu His Ser Phe Ser Glu Ala Lys Lys Leu Cys Ser Lys His Asp His
        1555                1560                1565
Ser Ala Thr Ile Val Ser Ile Lys Asp Glu Asp Glu Asn Lys Phe Val
    1570                1575                1580
Ser Arg Leu Met Arg Glu Asn Asn Asn Ile Thr Met Arg Val Trp Leu
1585                1590                1595                1600
Gly Leu Ser Gln His Ser Val Asp Gln Ser Trp Ser Trp Leu Asp Gly
                1605                1610                1615
Ser Glu Val Thr Phe Val Lys Trp Glu Asn Lys Ser Lys Ser Gly Val
            1620                1625                1630
Gly Arg Cys Ser Met Leu Ile Ala Ser Asn Glu Thr Trp Lys Lys Val
        1635                1640                1645
Glu Cys Glu His Gly Phe Gly Arg Val Val Cys Lys Val Pro Leu Gly
    1650                1655                1660
Pro Asp Tyr Thr Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu
1665                1670                1675                1680
Val Leu Met Gly Gly Leu Ile Trp Phe Leu Phe Gln Arg His Arg Leu
                1685                1690                1695
His Leu Ala Gly Phe Ser Ser Val Arg Tyr Ala Gln Gly Val Asn Glu
            1700                1705                1710
Asp Glu Ile Met Leu Pro Ser Phe His Asp
        1715                1720

<210> 667
<211> 1722
<212> PRT
<213> Homo sapiens

<400> 667
Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met
 1               5                  10                  15
Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala
            20                  25                  30
Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys
        35                  40                  45
Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp
    50                  55                  60
Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser
65                  70                  75                  80
Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg
                85                  90                  95
Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His
            100                 105                 110
His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly
        115                 120                 125
His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly
    130                 135                 140
Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg
145                 150                 155                 160
Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp
                165                 170                 175
Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro
            180                 185                 190
Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile
        195                 200                 205
Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu
    210                 215                 220
Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp
225                 230                 235                 240
Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser
                245                 250                 255
Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Asp Lys Glu Gly Ile
            260                 265                 270
Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly
        275                 280                 285
Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro
    290                 295                 300
Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met
305                 310                 315                 320
Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu
                325                 330                 335
Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp
            340                 345                 350
Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn
        355                 360                 365
Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys
    370                 375                 380
Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His
385                 390                 395                 400
Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp
                405                 410                 415
Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr
            420                 425                 430
Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp
        435                 440                 445
Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser
    450                 455                 460
Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys
465                 470                 475                 480
Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser
                485                 490                 495
Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu
            500                 505                 510
Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys
        515                 520                 525
Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu
    530                 535                 540
Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu
545                 550                 555                 560
Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly
                565                 570                 575
Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala
            580                 585                 590
Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys
        595                 600                 605
Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys
    610                 615                 620
Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp
625                 630                 635                 640
Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys
                645                 650                 655
Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu
            660                 665                 670
Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe
        675                 680                 685
Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln
    690                 695                 700
Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro
705                 710                 715                 720
Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr
                725                 730                 735
Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys
            740                 745                 750
Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe
        755                 760                 765
Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr
    770                 775                 780
Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr
785                 790                 795                 800
Pro Asp Trp Tyr Asn Pro Glu Arg Ala Gly Ile His Gly Pro Pro Leu
                805                 810                 815
Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn
            820                 825                 830
Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala
        835                 840                 845
Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala
    850                 855                 860
Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp
865                 870                 875                 880
Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe
                885                 890                 895
Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp
            900                 905                 910
Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe
        915                 920                 925
Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp
    930                 935                 940
Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn
945                 950                 955                 960
Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala
                965                 970                 975
Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser
            980                 985                 990
Gln Ile Glu Gln Asp Phe Ile Thr Ser Leu Leu Pro Asp Met Glu Ala
        995                 1000                1005
Thr Leu Trp Ile Gly Leu Arg Trp Thr Ala Tyr Glu Lys Ile Asn Lys
    1010                1015                1020
Trp Thr Asp Asn Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu
1025                1030                1035                1040
Val Ser Gly Arg Leu Arg Ile Pro Glu Asn Phe Phe Glu Glu Glu Ser
                1045                1050                1055
Arg Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys Ser Pro Phe Thr
            1060                1065                1070
Gly Thr Trp Asn Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu
        1075                1080                1085
Cys Gln Lys Tyr Ser Glu Val Lys Ser Arg Gln Thr Leu Gln Asn Ala
    1090                1095                1100
Ser Glu Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile Pro Lys
1105                1110                1115                1120
Thr Leu Thr Trp His Ser Ala Lys Arg Glu Cys Leu Lys Ser Asn Met
                1125                1130                1135
Gln Leu Val Ser Ile Thr Asp Pro Tyr Gln Gln Ala Phe Leu Ser Val
            1140                1145                1150
Gln Ala Leu Leu His Asn Ser Ser Leu Trp Ile Gly Leu Phe Ser Gln
        1155                1160                1165
Asp Asp Glu Leu Asn Phe Gly Trp Ser Asp Gly Lys Arg Leu His Phe
    1170                1175                1180
Ser Arg Trp Ala Glu Thr Asn Gly Gln Leu Glu Asp Cys Val Val Leu
1185                1190                1195                1200
Asp Thr Asp Gly Phe Trp Lys Thr Val Asp Cys Asn Asp Asn Gln Pro
                1205                1210                1215
Gly Ala Ile Cys Tyr Tyr Ser Gly Asn Glu Thr Glu Lys Glu Val Lys
            1220                1225                1230
Pro Val Asp Ser Val Lys Cys Pro Ser Pro Val Leu Asn Thr Pro Trp
        1235                1240                1245
Ile Pro Phe Gln Asn Cys Cys Tyr Asn Phe Ile Ile Thr Lys Asn Arg
    1250                1255                1260
His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys Cys Gln Lys Leu
1265                1270                1275                1280
Asn Pro Lys Ser His Ile Leu Ser Ile Arg Asp Glu Lys Glu Asn Asn
                1285                1290                1295
Phe Val Leu Glu Gln Leu Leu Tyr Phe Asn Tyr Met Ala Ser Trp Val
            1300                1305                1310
Met Leu Gly Ile Thr Tyr Arg Asn Lys Ser Leu Met Trp Phe Asp Lys
        1315                1320                1325
Thr Pro Leu Ser Tyr Thr His Trp Arg Ala Gly Arg Pro Thr Ile Lys
    1330                1335                1340
Asn Glu Lys Phe Leu Ala Gly Leu Ser Thr Asp Gly Phe Trp Asp Ile
1345                1350                1355                1360
Gln Thr Phe Lys Val Ile Glu Glu Ala Val Tyr Phe His Gln His Ser
                1365                1370                1375
Ile Leu Ala Cys Lys Ile Glu Met Val Asp Tyr Lys Glu Glu Tyr Asn
            1380                1385                1390
Thr Thr Leu Pro Gln Phe Met Pro Tyr Glu Asp Gly Ile Tyr Ser Val
        1395                1400                1405
Ile Gln Lys Lys Val Thr Trp Tyr Glu Ala Leu Asn Met Cys Ser Gln
    1410                1415                1420
Ser Gly Gly His Leu Ala Ser Val His Asn Gln Asn Gly Gln Leu Phe
1425                1430                1435                1440
Leu Glu Asp Ile Val Lys Arg Asp Gly Phe Pro Leu Trp Val Gly Leu
                1445                1450                1455
Ser Ser His Asp Gly Ser Glu Ser Ser Phe Glu Trp Ser Asp Gly Ser
            1460                1465                1470
Thr Phe Asp Tyr Ile Pro Trp Lys Gly Gln Thr Ser Pro Gly Asn Cys
        1475                1480                1485
Val Leu Leu Asp Pro Lys Gly Thr Trp Lys His Glu Lys Cys Asn Ser
    1490                1495                1500
Val Lys Asp Gly Ala Ile Cys Tyr Lys Pro Thr Lys Ser Lys Lys Leu
1505                1510                1515                1520
Ser Arg Leu Thr Tyr Ser Ser Arg Cys Pro Ala Ala Lys Glu Asn Gly
                1525                1530                1535
Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp Gln Ala
            1540                1545                1550
Leu His Ser Phe Ser Glu Ala Lys Lys Leu Cys Ser Lys His Asp His
        1555                1560                1565
Ser Ala Thr Ile Val Ser Ile Lys Asp Glu Asp Glu Asn Lys Phe Val
    1570                1575                1580
Ser Arg Leu Met Arg Glu Asn Asn Asn Ile Thr Met Arg Val Trp Leu
1585                1590                1595                1600
Gly Leu Ser Gln His Ser Val Asp Gln Ser Trp Ser Trp Leu Asp Gly
                1605                1610                1615
Ser Glu Val Thr Phe Val Lys Trp Glu Asn Lys Ser Lys Ser Gly Val
            1620                1625                1630
Gly Arg Cys Ser Met Leu Ile Ala Ser Asn Glu Thr Trp Lys Lys Val
        1635                1640                1645
Glu Cys Glu His Gly Phe Gly Arg Val Val Cys Lys Val Pro Leu Gly
    1650                1655                1660
Pro Asp Tyr Thr Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu
1665                1670                1675                1680
Val Leu Met Gly Gly Leu Ile Trp Phe Leu Phe Gln Arg His Arg Leu
                1685                1690                1695
His Leu Ala Gly Phe Ser Ser Val Arg Tyr Ala Gln Gly Val Asn Glu
            1700                1705                1710
Asp Glu Ile Met Leu Pro Ser Phe His Asp
        1715                1720

<210> 668
<211> 1743
<212> PRT
<213> Homo sapiens

<400> 668
Asn Ser Gly Gly Gly Ser Arg Val Arg Pro Arg Thr Arg Pro Glu Gly
 1               5                  10                  15
Leu Arg Gln Leu Arg Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro
            20                  25                  30
Ala Gly Leu Leu Met Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro
        35                  40                  45
Ser Gly Arg Ala Ala Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr
    50                  55                  60
Gly Lys Cys Ile Lys Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys
65                  70                  75                  80
Asp Glu Thr Glu Asp Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu
                85                  90                  95
Phe His Leu His Ser Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser
            100                 105                 110
Val Asn Glu Leu Arg Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp
        115                 120                 125
Trp Lys Cys Glu His His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu
    130                 135                 140
Ala Leu Lys Asp Gly His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val
145                 150                 155                 160
Trp Lys Lys Gly Gly Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His
                165                 170                 175
Glu Ile Tyr Thr Arg Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe
            180                 185                 190
Pro Phe Leu Ile Asp Gly Thr Trp His His Asp Cys Ile Leu Asp Glu
        195                 200                 205
Asp His Ser Gly Pro Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp
    210                 215                 220
Arg Lys Trp Gly Ile Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn
225                 230                 235                 240
Trp Glu Lys Asn Glu Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln
                245                 250                 255
Thr Ala Leu Ser Trp Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly
            260                 265                 270
Ala Asp Leu Leu Ser Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys
        275                 280                 285
Asp Lys Glu Gly Ile Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu
    290                 295                 300
Tyr Ser Ala Arg Gly Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe
305                 310                 315                 320
Leu Asn Trp Asp Pro Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser
                325                 330                 335
Ser Cys Ala Arg Met Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser
            340                 345                 350
Cys Glu Ala Gln Leu Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr
        355                 360                 365
Val Glu Leu Thr Asp Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala
    370                 375                 380
Gly Trp Leu Pro Asn Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser
385                 390                 395                 400
Asn Ser Trp Asp Lys Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp
                405                 410                 415
Leu Ile Ser Ile His Ser Leu Ala Asp Val Glu Val Val Val Thr Lys
            420                 425                 430
Leu His Asn Glu Asp Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn
        435                 440                 445
Ile Asn Ile Pro Thr Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr
    450                 455                 460
Leu Thr Tyr Trp Asp Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr
465                 470                 475                 480
Pro Asn Cys Val Ser Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln
                485                 490                 495
Ser Cys Glu Glu Lys Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys
            500                 505                 510
Leu Asn Asp Ala Ser Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp
        515                 520                 525
Lys Arg His Gly Glu Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro
    530                 535                 540
Phe Gly Thr Asn Cys Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu
545                 550                 555                 560
Tyr Leu Asn Asp Leu Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr
                565                 570                 575
Phe Trp Thr Gly Leu Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp
            580                 585                 590
Ala Thr Val Gly Gly Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn
        595                 600                 605
Phe Leu Glu Pro Ala Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly
    610                 615                 620
Lys Ser Val Gly Lys Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala
625                 630                 635                 640
Leu Ser Ile Cys Lys Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala
                645                 650                 655
Ser Pro Lys Pro Asp Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro
            660                 665                 670
Ala Ser Leu Ser Cys Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg
        675                 680                 685
Lys Arg Asn Trp Glu Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala
    690                 695                 700
His Leu Ser Ser Phe Ser His Val Asp Glu Ile Lys Glu Phe Leu His
705                 710                 715                 720
Phe Leu Thr Asp Gln Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu
                725                 730                 735
Asn Lys Arg Ser Pro Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg
            740                 745                 750
Thr Pro Val Ser Thr Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr
        755                 760                 765
Asp Ile Arg Asp Cys Ala Ala Val Lys Val Phe His Arg Pro Trp Arg
    770                 775                 780
Arg Gly Trp His Phe Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro
785                 790                 795                 800
Phe Ala Cys Asp Thr Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly
                805                 810                 815
Arg Thr Pro Lys Thr Pro Asp Trp Tyr Asn Pro Glu Arg Ala Gly Ile
            820                 825                 830
His Gly Pro Pro Leu Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala
        835                 840                 845
Asp Leu His Leu Asn Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn
    850                 855                 860
His Ser Phe Leu Ala Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile
865                 870                 875                 880
Lys Asn Lys Ile Ala Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile
                885                 890                 895
Arg Ile Ser Glu Trp Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr
            900                 905                 910
Pro Trp His Arg Phe Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met
        915                 920                 925
Ser Ala Lys Thr Trp Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser
    930                 935                 940
Thr Lys Leu Pro Phe Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu
945                 950                 955                 960
Lys Tyr Ser Pro Asp Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp
                965                 970                 975
Ile Pro Phe Gln Asn Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu
            980                 985                 990
Thr Phe Ser Gln Ala Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu
        995                 1000                1005
Pro Ser Val Leu Ser Gln Ile Glu Gln Asp Phe Ile Thr Ser Leu Leu
    1010                1015                1020
Pro Asp Met Glu Ala Thr Leu Trp Ile Gly Leu Arg Trp Thr Ala Tyr
1025                1030                1035                1040
Glu Lys Ile Asn Lys Trp Thr Asp Asn Arg Glu Leu Thr Tyr Ser Asn
                1045                1050                1055
Phe His Pro Leu Leu Val Ser Gly Arg Leu Arg Ile Pro Glu Asn Phe
            1060                1065                1070
Phe Glu Glu Glu Ser Arg Tyr His Cys Ala Leu Ile Leu Asn Leu Gln
        1075                1080                1085
Lys Ser Pro Phe Thr Gly Thr Trp Asn Phe Thr Ser Cys Ser Glu Arg
    1090                1095                1100
His Phe Val Ser Leu Cys Gln Lys Tyr Ser Glu Val Lys Ser Arg Gln
1105                1110                1115                1120
Thr Leu Gln Asn Ala Ser Glu Thr Val Lys Tyr Leu Asn Asn Leu Tyr
                1125                1130                1135
Lys Ile Ile Pro Lys Thr Leu Thr Trp His Ser Ala Lys Arg Glu Cys
            1140                1145                1150
Leu Lys Ser Asn Met Gln Leu Val Ser Ile Thr Asp Pro Tyr Gln Gln
        1155                1160                1165
Ala Phe Leu Ser Val Gln Ala Leu Leu His Asn Ser Ser Leu Trp Ile
    1170                1175                1180
Gly Leu Phe Ser Gln Asp Asp Glu Leu Asn Phe Gly Trp Ser Asp Gly
1185                1190                1195                1200
Lys Arg Leu His Phe Ser Arg Trp Ala Glu Thr Asn Gly Gln Leu Glu
                1205                1210                1215
Asp Cys Val Val Leu Asp Thr Asp Gly Phe Trp Lys Thr Val Asp Cys
            1220                1225                1230
Asn Asp Asn Gln Pro Gly Ala Ile Cys Tyr Tyr Pro Gly Asn Glu Thr
        1235                1240                1245
Glu Lys Glu Val Lys Pro Val Asp Ser Val Lys Cys Pro Ser Pro Val
    1250                1255                1260
Leu Asn Thr Pro Trp Ile Pro Phe Gln Asn Cys Cys Tyr Asn Phe Ile
1265                1270                1275                1280
Ile Thr Lys Asn Arg His Met Ala Thr Thr Gln Asp Glu Val His Thr
                1285                1290                1295
Lys Cys Gln Lys Leu Asn Pro Lys Ser His Ile Leu Ser Ile Arg Asp
            1300                1305                1310
Glu Lys Glu Asn Asn Phe Val Leu Glu Gln Leu Leu Tyr Phe Asn Tyr
        1315                1320                1325
Met Ala Ser Trp Val Met Leu Gly Ile Thr Tyr Arg Asn Asn Ser Leu
    1330                1335                1340
Met Trp Phe Asp Lys Thr Pro Leu Ser Tyr Thr His Trp Arg Ala Gly
1345                1350                1355                1360
Arg Pro Thr Ile Lys Asn Glu Arg Phe Leu Ala Gly Leu Ser Thr Asp
                1365                1370                1375
Gly Phe Trp Asp Ile Gln Thr Phe Lys Val Ile Glu Glu Ala Val Tyr
            1380                1385                1390
Phe His Gln His Ser Ile Leu Ala Cys Lys Ile Glu Met Val Asp Tyr
        1395                1400                1405
Lys Glu Glu Tyr Asn Thr Thr Leu Pro Gln Phe Met Pro Tyr Glu Asp
    1410                1415                1420
Gly Ile Tyr Ser Val Ile Gln Lys Lys Val Thr Trp Tyr Glu Ala Leu
1425                1430                1435                1440
Asn Met Cys Ser Gln Ser Gly Gly His Leu Ala Ser Val His Asn Gln
                1445                1450                1455
Asn Gly Gln Leu Phe Leu Glu Asp Ile Val Lys Arg Asp Gly Phe Pro
            1460                1465                1470
Leu Trp Val Gly Leu Ser Ser His Asp Gly Ser Glu Ser Ser Phe Glu
        1475                1480                1485
Trp Ser Asp Gly Ser Thr Phe Asp Tyr Ile Pro Trp Lys Gly Gln Thr
    1490                1495                1500
Ser Pro Gly Asn Cys Val Leu Leu Asp Pro Lys Gly Thr Trp Lys His
1505                1510                1515                1520
Glu Lys Cys Asn Ser Val Lys Asp Gly Ala Ile Cys Tyr Lys Pro Thr
                1525                1530                1535
Lys Ala Lys Lys Leu Ser Arg Leu Thr Tyr Ser Ser Arg Cys Pro Ala
            1540                1545                1550
Ala Lys Glu Asn Gly Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr
        1555                1560                1565
Lys Ser Asp Gln Ala Leu His Ser Phe Ser Glu Ala Lys Lys Leu Cys
    1570                1575                1580
Ser Lys His Asp His Ser Ala Thr Ile Val Ser Ile Lys Asp Glu Asp
1585                1590                1595                1600
Glu Asn Lys Phe Val Ser Arg Leu Met Arg Glu Asn Asn Asn Ile Thr
                1605                1610                1615
Met Arg Val Trp Leu Gly Leu Ser Gln His Ser Val Asp Gln Ser Trp
            1620                1625                1630
Ser Trp Leu Asp Gly Ser Glu Val Thr Phe Val Lys Trp Glu Asn Lys
        1635                1640                1645
Ser Lys Ser Gly Val Gly Arg Cys Ser Met Leu Ile Ala Ser Asn Glu
    1650                1655                1660
Thr Trp Lys Lys Val Glu Cys Glu His Gly Phe Gly Arg Val Val Cys
1665                1670                1675                1680
Lys Val Pro Leu Gly Pro Asp Tyr Thr Ala Ile Ala Ile Ile Val Ala
                1685                1690                1695
Thr Leu Ser Ile Leu Val Leu Met Gly Gly Leu Ile Trp Phe Leu Phe
            1700                1705                1710
Gln Arg His Arg Leu His Leu Ala Gly Phe Ser Ser Val Arg Tyr Ala
        1715                1720                1725
Gln Gly Val Asn Glu Asp Glu Ile Met Leu Pro Ser Phe His Asp
    1730                1735                1740

<210> 669
<211> 36
<212> PRT
<213> Homo sapiens

<400> 669
Ser Gln His Arg Leu Phe His Leu His Ser Gln Lys Cys Leu Gly Leu
 1               5                  10                  15
Asp Ile Thr Lys Ser Val Asn Glu Leu Arg Met Phe Ser Cys Asp Ser
            20                  25                  30
Ser Ala Met Leu
        35

<210> 670
<211> 1722
<212> PRT
<213> Homo sapiens

<400> 670
Met Arg Thr Gly Trp Ala His Pro Ser Pro Pro Gly Gly Ala Pro His
 1               5                  10                  15
Ala Ala Leu Leu Val Leu Arg Ser Arg Gly Ala Leu Trp Pro Arg Thr
            20                  25                  30
Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys
        35                  40                  45
Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp
    50                  55                  60
Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser
65                  70                  75                  80
Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg
                85                  90                  95
Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His
            100                 105                 110
His Ser Leu Tyr Gly Ala Ala Arg Tyr Trp Leu Ala Leu Lys Asp Gly
        115                 120                 125
His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly
    130                 135                 140
Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg
145                 150                 155                 160
Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp
                165                 170                 175
Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro
            180                 185                 190
Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile
        195                 200                 205
Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu
    210                 215                 220
Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp
225                 230                 235                 240
Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser
                245                 250                 255
Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile
            260                 265                 270
Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly
        275                 280                 285
Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro
    290                 295                 300
Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met
305                 310                 315                 320
Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu
                325                 330                 335
Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp
            340                 345                 350
Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn
        355                 360                 365
Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys
    370                 375                 380
Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His
385                 390                 395                 400
Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp
                405                 410                 415
Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr
            420                 425                 430
Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp
        435                 440                 445
Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser
    450                 455                 460
Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys
465                 470                 475                 480
Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser
                485                 490                 495
Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu
            500                 505                 510
Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys
        515                 520                 525
Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu
    530                 535                 540
Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu
545                 550                 555                 560
Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly
                565                 570                 575
Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala
            580                 585                 590
Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys
        595                 600                 605
Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys
    610                 615                 620
Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp
625                 630                 635                 640
Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys
                645                 650                 655
Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu
            660                 665                 670
Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe
        675                 680                 685
Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln
    690                 695                 700
Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro
705                 710                 715                 720
Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr
                725                 730                 735
Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys
            740                 745                 750
Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe
        755                 760                 765
Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr
    770                 775                 780
Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr
785                 790                 795                 800
Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu
                805                 810                 815
Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn
            820                 825                 830
Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala
        835                 840                 845
Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala
    850                 855                 860
Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp
865                 870                 875                 880
Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe
                885                 890                 895
Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp
            900                 905                 910
Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe
        915                 920                 925
Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp
    930                 935                 940
Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn
945                 950                 955                 960
Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala
                965                 970                 975
Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser
            980                 985                 990
Gln Ile Glu Gln Asp Phe Ile Thr Ser Leu Leu Pro Asp Met Glu Ala
        995                 1000                1005
Thr Leu Trp Ile Gly Leu Arg Trp Thr Ala Tyr Glu Lys Ile Asn Lys
    1010                1015                1020
Trp Thr Asp Asn Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu
1025                1030                1035                1040
Val Ser Gly Arg Leu Arg Ile Pro Glu Asn Phe Phe Glu Glu Glu Ser
                1045                1050                1055
Arg Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys Ser Pro Phe Thr
            1060                1065                1070
Gly Thr Trp Asn Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu
        1075                1080                1085
Cys Gln Lys Tyr Ser Glu Val Lys Ser Arg Gln Thr Leu Gln Asn Ala
    1090                1095                1100
Ser Glu Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile Pro Lys
1105                1110                1115                1120
Thr Leu Thr Trp His Ser Ala Lys Arg Glu Cys Leu Lys Ser Asn Met
                1125                1130                1135
Gln Leu Val Ser Ile Thr Asp Pro Tyr Gln Gln Ala Phe Leu Ser Val
            1140                1145                1150
Gln Ala Leu Leu His Asn Ser Ser Leu Trp Ile Gly Leu Phe Ser Gln
        1155                1160                1165
Asp Asp Glu Leu Asn Phe Gly Trp Ser Asp Gly Lys Arg Leu His Phe
    1170                1175                1180
Ser Arg Trp Ala Glu Thr Asn Gly Gln Leu Glu Asp Cys Val Val Leu
1185                1190                1195                1200
Asp Thr Asp Gly Phe Trp Lys Thr Val Asp Cys Asn Asp Asn Gln Pro
                1205                1210                1215
Gly Ala Ile Cys Tyr Tyr Ser Gly Asn Glu Thr Glu Lys Glu Val Lys
            1220                1225                1230
Pro Val Asp Ser Val Lys Cys Pro Ser Pro Val Leu Asn Thr Pro Trp
        1235                1240                1245
Ile Pro Phe Gln Asn Cys Cys Tyr Asn Phe Ile Ile Thr Lys Asn Arg
    1250                1255                1260
His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys Cys Gln Lys Leu
1265                1270                1275                1280
Asn Pro Lys Ser His Ile Leu Ser Ile Arg Asp Glu Lys Glu Asn Asn
                1285                1290                1295
Phe Val Leu Glu Gln Leu Leu Tyr Phe Asn Tyr Met Ala Ser Trp Val
            1300                1305                1310
Met Leu Gly Ile Thr Tyr Arg Asn Asn Ser Leu Met Trp Phe Asp Lys
        1315                1320                1325
Thr Pro Leu Ser Tyr Thr His Trp Arg Ala Gly Arg Pro Thr Ile Lys
    1330                1335                1340
Asn Glu Lys Phe Leu Ala Gly Leu Ser Thr Asp Gly Phe Trp Asp Ile
1345                1350                1355                1360
Gln Thr Phe Lys Val Ile Glu Glu Ala Val Tyr Phe His Gln His Ser
                1365                1370                1375
Ile Leu Ala Cys Lys Ile Glu Met Val Asp Tyr Lys Glu Glu His Asn
            1380                1385                1390
Thr Thr Leu Pro Gln Phe Met Pro Tyr Glu Asp Gly Ile Tyr Ser Val
        1395                1400                1405
Ile Gln Lys Lys Val Thr Trp Tyr Glu Ala Leu Asn Met Cys Ser Gln
    1410                1415                1420
Ser Gly Gly His Leu Ala Ser Val His Asn Gln Asn Gly Gln Leu Phe
1425                1430                1435                1440
Leu Glu Asp Ile Val Lys Arg Asp Gly Phe Pro Leu Trp Val Gly Leu
                1445                1450                1455
Ser Ser His Asp Gly Ser Glu Ser Ser Phe Glu Trp Ser Asp Gly Ser
            1460                1465                1470
Thr Phe Asp Tyr Ile Pro Trp Lys Gly Gln Thr Ser Pro Gly Asn Cys
        1475                1480                1485
Val Leu Leu Asp Pro Lys Gly Thr Trp Lys His Glu Lys Cys Asn Ser
    1490                1495                1500
Val Lys Asp Gly Ala Ile Cys Tyr Lys Pro Thr Lys Ser Lys Lys Leu
1505                1510                1515                1520
Ser Arg Leu Thr Tyr Ser Ser Arg Cys Pro Ala Ala Lys Glu Asn Gly
                1525                1530                1535
Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp Gln Ala
            1540                1545                1550
Leu His Ser Phe Ser Glu Ala Lys Lys Leu Cys Ser Lys His Asp His
        1555                1560                1565
Ser Ala Thr Ile Val Ser Ile Lys Asp Glu Asp Glu Asn Lys Phe Val
    1570                1575                1580
Ser Arg Leu Met Arg Glu Asn Asn Asn Ile Thr Met Arg Val Trp Leu
1585                1590                1595                1600
Gly Leu Ser Gln His Ser Val Asp Gln Ser Trp Ser Trp Leu Asp Gly
                1605                1610                1615
Ser Glu Val Thr Phe Val Lys Trp Glu Asn Lys Ser Lys Ser Gly Val
            1620                1625                1630
Gly Arg Cys Ser Met Leu Ile Ala Ser Asn Glu Thr Trp Lys Lys Val
        1635                1640                1645
Glu Cys Glu His Gly Phe Gly Arg Val Val Cys Lys Val Pro Leu Gly
    1650                1655                1660
Pro Asp Tyr Thr Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu
1665                1670                1675                1680
Val Leu Met Gly Gly Leu Ile Trp Phe Leu Phe Gln Arg His Arg Leu
                1685                1690                1695
His Leu Ala Gly Phe Ser Ser Val Arg Tyr Ala Gln Gly Val Asn Glu
            1700                1705                1710
Asp Glu Ile Met Leu Pro Ser Phe His Asp
        1715                1720

<210> 671
<211> 1722
<212> PRT
<213> Homo sapiens

<400> 671
Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met
 1               5                  10                  15
Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala
            20                  25                  30
Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys
        35                  40                  45
Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp
    50                  55                  60
Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser
65                  70                  75                  80
Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg
                85                  90                  95
Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His
            100                 105                 110
His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly
        115                 120                 125
His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly
    130                 135                 140
Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg
145                 150                 155                 160
Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp
                165                 170                 175
Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro
            180                 185                 190
Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile
        195                 200                 205
Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu
    210                 215                 220
Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp
225                 230                 235                 240
Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser
                245                 250                 255
Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile
            260                 265                 270
Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly
        275                 280                 285
Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro
    290                 295                 300
Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met
305                 310                 315                 320
Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu
                325                 330                 335
Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp
            340                 345                 350
Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn
        355                 360                 365
Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys
    370                 375                 380
Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His
385                 390                 395                 400
Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp
                405                 410                 415
Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr
            420                 425                 430
Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp
        435                 440                 445
Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser
    450                 455                 460
Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys
465                 470                 475                 480
Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser
                485                 490                 495
Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu
            500                 505                 510
Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys
        515                 520                 525
Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu
    530                 535                 540
Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu
545                 550                 555                 560
Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly
                565                 570                 575
Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala
            580                 585                 590
Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys
        595                 600                 605
Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys
    610                 615                 620
Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp
625                 630                 635                 640
Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys
                645                 650                 655
Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu
            660                 665                 670
Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe
        675                 680                 685
Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln
    690                 695                 700
Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro
705                 710                 715                 720
Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr
                725                 730                 735
Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys
            740                 745                 750
Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe
        755                 760                 765
Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr
    770                 775                 780
Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr
785                 790                 795                 800
Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu
                805                 810                 815
Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn
            820                 825                 830
Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala
        835                 840                 845
Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala
    850                 855                 860
Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp
865                 870                 875                 880
Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe
                885                 890                 895
Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp
            900                 905                 910
Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe
        915                 920                 925
Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp
    930                 935                 940
Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn
945                 950                 955                 960
Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala
                965                 970                 975
Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser
            980                 985                 990
Gln Ile Glu Gln Asp Phe Ile Thr Ser Leu Leu Pro Asp Met Glu Ala
        995                 1000                1005
Thr Leu Trp Ile Gly Leu Arg Trp Thr Ala Tyr Glu Lys Ile Asn Lys
    1010                1015                1020
Trp Thr Asp Asn Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu
1025                1030                1035                1040
Val Ser Gly Arg Leu Arg Ile Pro Glu Asn Phe Phe Glu Glu Glu Ser
                1045                1050                1055
Arg Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys Ser Pro Phe Thr
            1060                1065                1070
Gly Thr Trp Asn Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu
        1075                1080                1085
Cys Gln Lys Tyr Ser Glu Val Lys Ser Arg Gln Thr Leu Gln Asn Ala
    1090                1095                1100
Ser Glu Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile Pro Lys
1105                1110                1115                1120
Thr Leu Thr Trp His Ser Ala Lys Arg Glu Cys Leu Lys Ser Asn Met
                1125                1130                1135
Gln Leu Val Ser Ile Thr Asp Pro Tyr Gln Gln Ala Phe Leu Ser Val
            1140                1145                1150
Gln Ala Leu Leu His Asn Ser Ser Leu Trp Ile Gly Leu Phe Ser Gln
        1155                1160                1165
Asp Asp Glu Leu Asn Phe Gly Trp Ser Asp Gly Lys Arg Leu His Phe
    1170                1175                1180
Ser Arg Trp Ala Glu Thr Asn Gly Gln Leu Glu Asp Cys Val Val Leu
1185                1190                1195                1200
Asp Thr Asp Gly Phe Trp Lys Thr Val Asp Cys Asn Asp Asn Gln Pro
                1205                1210                1215
Gly Ala Ile Cys Tyr Tyr Ser Gly Asn Glu Thr Glu Lys Glu Val Lys
            1220                1225                1230
Pro Val Asp Ser Val Lys Cys Pro Ser Pro Val Leu Asn Thr Pro Trp
        1235                1240                1245
Ile Pro Phe Gln Asn Cys Cys Tyr Asn Phe Ile Ile Thr Lys Asn Arg
    1250                1255                1260
His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys Cys Gln Lys Leu
1265                1270                1275                1280
Asn Pro Lys Ser His Ile Leu Ser Ile Arg Asp Glu Lys Glu Asn Asn
                1285                1290                1295
Phe Val Leu Glu Gln Leu Leu Tyr Phe Asn Tyr Met Ala Ser Trp Val
            1300                1305                1310
Met Leu Gly Ile Thr Tyr Arg Asn Asn Ser Leu Met Trp Phe Asp Lys
        1315                1320                1325
Thr Pro Leu Ser Tyr Thr His Trp Arg Ala Gly Arg Pro Thr Ile Lys
    1330                1335                1340
Asn Glu Lys Phe Leu Ala Gly Leu Ser Thr Asp Gly Phe Trp Asp Ile
1345                1350                1355                1360
Gln Thr Phe Lys Val Ile Glu Glu Ala Val Tyr Phe His Gln His Ser
                1365                1370                1375
Ile Leu Ala Cys Lys Ile Glu Met Val Asp Tyr Lys Glu Glu His Asn
            1380                1385                1390
Thr Thr Leu Pro Gln Phe Met Pro Tyr Glu Asp Gly Ile Tyr Ser Val
        1395                1400                1405
Ile Gln Lys Lys Val Thr Trp Tyr Glu Ala Leu Asn Met Cys Ser Gln
    1410                1415                1420
Ser Gly Gly His Leu Ala Ser Val His Asn Gln Asn Gly Gln Leu Phe
1425                1430                1435                1440
Leu Glu Asp Ile Val Lys Arg Asp Gly Phe Pro Leu Trp Val Gly Leu
                1445                1450                1455
Ser Ser His Asp Gly Ser Glu Ser Ser Phe Glu Trp Ser Asp Gly Ser
            1460                1465                1470
Thr Phe Asp Tyr Ile Pro Trp Lys Gly Gln Thr Ser Pro Gly Asn Cys
        1475                1480                1485
Val Leu Leu Asp Pro Lys Gly Thr Trp Lys His Glu Lys Cys Asn Ser
    1490                1495                1500
Val Lys Asp Gly Ala Ile Cys Tyr Lys Pro Thr Lys Ser Lys Lys Leu
1505                1510                1515                1520
Ser Arg Leu Thr Tyr Ser Ser Arg Cys Pro Ala Ala Lys Glu Asn Gly
                1525                1530                1535
Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp Gln Ala
            1540                1545                1550
Leu His Ser Phe Ser Glu Ala Lys Lys Leu Cys Ser Lys His Asp His
        1555                1560                1565
Ser Ala Thr Ile Val Ser Ile Lys Asp Glu Asp Glu Asn Lys Phe Val
    1570                1575                1580
Ser Arg Leu Met Arg Glu Asn Asn Asn Ile Thr Met Arg Val Trp Leu
1585                1590                1595                1600
Gly Leu Ser Gln His Ser Val Asp Gln Ser Trp Ser Trp Leu Asp Gly
                1605                1610                1615
Ser Glu Val Thr Phe Val Lys Trp Glu Asn Lys Ser Lys Ser Gly Val
            1620                1625                1630
Gly Arg Cys Ser Met Leu Ile Ala Ser Asn Glu Thr Trp Lys Lys Val
        1635                1640                1645
Glu Cys Glu His Gly Phe Gly Arg Val Val Cys Lys Val Pro Leu Gly
    1650                1655                1660
Pro Asp Tyr Thr Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu
1665                1670                1675                1680
Val Leu Met Gly Gly Leu Ile Trp Phe Leu Phe Gln Arg His Arg Leu
                1685                1690                1695
His Leu Ala Gly Phe Ser Ser Val Arg Tyr Ala Gln Gly Val Asn Glu
            1700                1705                1710
Asp Glu Ile Met Leu Pro Ser Phe His Asp
        1715                1720

<210> 672
<211> 1722
<212> PRT
<213> Homo sapiens

<400> 672
Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met
 1               5                  10                  15
Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala
            20                  25                  30
Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys
        35                  40                  45
Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp
    50                  55                  60
Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser
65                  70                  75                  80
Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg
                85                  90                  95
Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His
            100                 105                 110
His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly
        115                 120                 125
His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly
    130                 135                 140
Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg
145                 150                 155                 160
Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp
                165                 170                 175
Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro
            180                 185                 190
Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile
        195                 200                 205
Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu
    210                 215                 220
Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp
225                 230                 235                 240
Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser
                245                 250                 255
Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile
            260                 265                 270
Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly
        275                 280                 285
Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro
    290                 295                 300
Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met
305                 310                 315                 320
Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu
                325                 330                 335
Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp
            340                 345                 350
Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn
        355                 360                 365
Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys
    370                 375                 380
Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His
385                 390                 395                 400
Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp
                405                 410                 415
Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr
            420                 425                 430
Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp
        435                 440                 445
Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser
    450                 455                 460
Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys
465                 470                 475                 480
Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser
                485                 490                 495
Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu
            500                 505                 510
Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys
        515                 520                 525
Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu
    530                 535                 540
Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu
545                 550                 555                 560
Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly
                565                 570                 575
Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala
            580                 585                 590
Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys
        595                 600                 605
Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys
    610                 615                 620
Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp
625                 630                 635                 640
Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys
                645                 650                 655
Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu
            660                 665                 670
Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe
        675                 680                 685
Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln
    690                 695                 700
Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro
705                 710                 715                 720
Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr
                725                 730                 735
Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys
            740                 745                 750
Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe
        755                 760                 765
Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr
    770                 775                 780
Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr
785                 790                 795                 800
Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu
                805                 810                 815
Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn
            820                 825                 830
Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala
        835                 840                 845
Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala
    850                 855                 860
Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp
865                 870                 875                 880
Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe
                885                 890                 895
Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp
            900                 905                 910
Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe
        915                 920                 925
Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp
    930                 935                 940
Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn
945                 950                 955                 960
Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala
                965                 970                 975
Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser
            980                 985                 990
Gln Ile Glu Gln Asp Phe Ile Thr Ser Leu Leu Pro Asp Met Glu Ala
        995                 1000                1005
Thr Leu Trp Ile Gly Leu Arg Trp Thr Ala Tyr Glu Lys Ile Asn Lys
    1010                1015                1020
Trp Thr Asp Asn Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu
1025                1030                1035                1040
Val Ser Gly Arg Leu Arg Ile Pro Glu Asn Phe Phe Glu Glu Glu Ser
                1045                1050                1055
Arg Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys Ser Pro Phe Thr
            1060                1065                1070
Gly Thr Trp Asn Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu
        1075                1080                1085
Cys Gln Lys Tyr Ser Glu Val Lys Ser Arg Gln Thr Leu Gln Asn Ala
    1090                1095                1100
Ser Glu Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile Pro Lys
1105                1110                1115                1120
Thr Leu Thr Trp His Ser Ala Lys Arg Glu Cys Leu Lys Ser Asn Met
                1125                1130                1135
Gln Leu Val Ser Ile Thr Asp Pro Tyr Gln Gln Ala Phe Leu Ser Val
            1140                1145                1150
Gln Ala Leu Leu His Asn Ser Ser Leu Trp Ile Gly Leu Phe Ser Gln
        1155                1160                1165
Asp Asp Glu Leu Asn Phe Gly Trp Ser Asp Gly Lys Arg Leu His Phe
    1170                1175                1180
Ser Arg Trp Ala Glu Thr Asn Gly Gln Leu Glu Asp Cys Val Val Leu
1185                1190                1195                1200
Asp Thr Asp Gly Phe Trp Lys Thr Val Asp Cys Asn Asp Asn Gln Pro
                1205                1210                1215
Gly Ala Ile Cys Tyr Tyr Ser Gly Asn Glu Thr Glu Lys Glu Val Lys
            1220                1225                1230
Pro Val Asp Ser Val Lys Cys Pro Ser Pro Val Leu Asn Thr Pro Trp
        1235                1240                1245
Ile Pro Phe Gln Asn Cys Cys Tyr Asn Phe Ile Ile Thr Lys Asn Arg
    1250                1255                1260
His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys Cys Gln Lys Leu
1265                1270                1275                1280
Asn Pro Lys Ser His Ile Leu Ser Ile Arg Asp Glu Lys Glu Asn Asn
                1285                1290                1295
Phe Val Leu Glu Gln Leu Leu Tyr Phe Asn Tyr Met Ala Ser Trp Val
            1300                1305                1310
Met Leu Gly Ile Thr Tyr Arg Asn Asn Ser Leu Met Trp Phe Asp Lys
        1315                1320                1325
Thr Pro Leu Ser Tyr Thr His Trp Arg Ala Gly Arg Pro Thr Ile Lys
    1330                1335                1340
Asn Glu Lys Phe Leu Ala Gly Leu Ser Thr Asp Gly Phe Trp Asp Ile
1345                1350                1355                1360
Gln Thr Phe Lys Val Ile Glu Glu Ala Val Tyr Phe His Gln His Ser
                1365                1370                1375
Ile Leu Ala Cys Lys Ile Glu Met Val Asp Tyr Lys Glu Glu His Asn
            1380                1385                1390
Thr Thr Leu Pro Gln Phe Met Pro Tyr Glu Asp Gly Ile Tyr Ser Val
        1395                1400                1405
Ile Gln Lys Lys Val Thr Trp Tyr Glu Ala Leu Asn Met Cys Ser Gln
    1410                1415                1420
Ser Gly Gly His Leu Ala Ser Val His Asn Gln Asn Gly Gln Leu Phe
1425                1430                1435                1440
Leu Glu Asp Ile Val Lys Arg Asp Gly Phe Pro Leu Trp Val Gly Leu
                1445                1450                1455
Ser Ser His Asp Gly Ser Glu Ser Ser Phe Glu Trp Ser Asp Gly Ser
            1460                1465                1470
Thr Phe Asp Tyr Ile Pro Trp Lys Gly Gln Thr Ser Pro Gly Asn Cys
        1475                1480                1485
Val Leu Leu Asp Pro Lys Gly Thr Trp Lys His Glu Lys Cys Asn Ser
    1490                1495                1500
Val Lys Asp Gly Ala Ile Cys Tyr Lys Pro Thr Lys Ser Lys Lys Leu
1505                1510                1515                1520
Ser Arg Leu Thr Tyr Ser Ser Arg Cys Pro Ala Ala Lys Glu Asn Gly
                1525                1530                1535
Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp Gln Ala
            1540                1545                1550
Leu His Ser Phe Ser Glu Ala Lys Lys Leu Cys Ser Lys His Asp His
        1555                1560                1565
Ser Ala Thr Ile Val Ser Ile Lys Asp Glu Asp Glu Asn Lys Phe Val
    1570                1575                1580
Ser Arg Leu Met Arg Glu Asn Asn Asn Ile Thr Met Arg Val Trp Leu
1585                1590                1595                1600
Gly Leu Ser Gln His Ser Val Asp Gln Ser Trp Ser Trp Leu Asp Gly
                1605                1610                1615
Ser Glu Val Thr Phe Val Lys Trp Glu Asn Lys Ser Lys Ser Gly Val
            1620                1625                1630
Gly Arg Cys Ser Met Leu Ile Ala Ser Asn Glu Thr Trp Lys Lys Val
        1635                1640                1645
Glu Cys Glu His Gly Phe Gly Arg Val Val Cys Lys Val Pro Leu Gly
    1650                1655                1660
Pro Asp Tyr Thr Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu
1665                1670                1675                1680
Val Leu Met Gly Gly Leu Ile Trp Phe Leu Phe Gln Arg His Arg Leu
                1685                1690                1695
His Leu Ala Gly Phe Ser Ser Val Arg Tyr Ala Gln Gly Val Asn Glu
            1700                1705                1710
Asp Glu Ile Met Leu Pro Ser Phe His Asp
        1715                1720

<210> 673
<211> 1722
<212> PRT
<213> Homo sapiens

<400> 673
Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met
 1               5                  10                  15
Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala
            20                  25                  30
Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys
        35                  40                  45
Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp
    50                  55                  60
Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser
65                  70                  75                  80
Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg
                85                  90                  95
Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His
            100                 105                 110
His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly
        115                 120                 125
His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly
    130                 135                 140
Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg
145                 150                 155                 160
Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp
                165                 170                 175
Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro
            180                 185                 190
Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile
        195                 200                 205
Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu
    210                 215                 220
Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp
225                 230                 235                 240
Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser
                245                 250                 255
Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Asp Lys Glu Gly Ile
            260                 265                 270
Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly
        275                 280                 285
Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro
    290                 295                 300
Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met
305                 310                 315                 320
Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu
                325                 330                 335
Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp
            340                 345                 350
Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn
        355                 360                 365
Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys
    370                 375                 380
Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His
385                 390                 395                 400
Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp
                405                 410                 415
Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr
            420                 425                 430
Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp
        435                 440                 445
Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser
    450                 455                 460
Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys
465                 470                 475                 480
Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser
                485                 490                 495
Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu
            500                 505                 510
Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys
        515                 520                 525
Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu
    530                 535                 540
Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu
545                 550                 555                 560
Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly
                565                 570                 575
Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala
            580                 585                 590
Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys
        595                 600                 605
Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys
    610                 615                 620
Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp
625                 630                 635                 640
Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys
                645                 650                 655
Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu
            660                 665                 670
Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe
        675                 680                 685
Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln
    690                 695                 700
Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro
705                 710                 715                 720
Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr
                725                 730                 735
Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys
            740                 745                 750
Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe
        755                 760                 765
Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr
    770                 775                 780
Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr
785                 790                 795                 800
Pro Asp Trp Tyr Asn Pro Glu Arg Ala Gly Ile His Gly Pro Pro Leu
                805                 810                 815
Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn
            820                 825                 830
Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala
        835                 840                 845
Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala
    850                 855                 860
Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp
865                 870                 875                 880
Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe
                885                 890                 895
Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp
            900                 905                 910
Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe
        915                 920                 925
Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp
    930                 935                 940
Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn
945                 950                 955                 960
Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala
                965                 970                 975
Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser
            980                 985                 990
Gln Ile Glu Gln Asp Phe Ile Thr Ser Leu Leu Pro Asp Met Glu Ala
        995                 1000                1005
Thr Leu Trp Ile Gly Leu Arg Trp Thr Ala Tyr Glu Lys Ile Asn Lys
    1010                1015                1020
Trp Thr Asp Asn Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu
1025                1030                1035                1040
Val Ser Gly Arg Leu Arg Ile Pro Glu Asn Phe Phe Glu Glu Glu Ser
                1045                1050                1055
Arg Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys Ser Pro Phe Thr
            1060                1065                1070
Gly Thr Trp Asn Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu
        1075                1080                1085
Cys Gln Lys Tyr Ser Glu Val Lys Ser Arg Gln Thr Leu Gln Asn Ala
    1090                1095                1100
Ser Glu Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile Pro Lys
1105                1110                1115                1120
Thr Leu Thr Trp His Ser Ala Lys Arg Glu Cys Leu Lys Ser Asn Met
                1125                1130                1135
Gln Leu Val Ser Ile Thr Asp Pro Tyr Gln Gln Ala Phe Leu Ser Val
            1140                1145                1150
Gln Ala Leu Leu His Asn Ser Ser Leu Trp Ile Gly Leu Phe Ser Gln
        1155                1160                1165
Asp Asp Glu Leu Asn Phe Gly Trp Ser Asp Gly Lys Arg Leu His Phe
    1170                1175                1180
Ser Arg Trp Ala Glu Thr Asn Gly Gln Leu Glu Asp Cys Val Val Leu
1185                1190                1195                1200
Asp Thr Asp Gly Phe Trp Lys Thr Val Asp Cys Asn Asp Asn Gln Pro
                1205                1210                1215
Gly Ala Ile Cys Tyr Tyr Ser Gly Asn Glu Thr Glu Lys Glu Val Lys
            1220                1225                1230
Pro Val Asp Ser Val Lys Cys Pro Ser Pro Val Leu Asn Thr Pro Trp
        1235                1240                1245
Ile Pro Phe Gln Asn Cys Cys Tyr Asn Phe Ile Ile Thr Lys Asn Arg
    1250                1255                1260
His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys Cys Gln Lys Leu
1265                1270                1275                1280
Asn Pro Lys Ser His Ile Leu Ser Ile Arg Asp Glu Lys Glu Asn Asn
                1285                1290                1295
Phe Val Leu Glu Gln Leu Leu Tyr Phe Asn Tyr Met Ala Ser Trp Val
            1300                1305                1310
Met Leu Gly Ile Thr Tyr Arg Asn Lys Ser Leu Met Trp Phe Asp Lys
        1315                1320                1325
Thr Pro Leu Ser Tyr Thr His Trp Arg Ala Gly Arg Pro Thr Ile Lys
    1330                1335                1340
Asn Glu Lys Phe Leu Ala Gly Leu Ser Thr Asp Gly Phe Trp Asp Ile
1345                1350                1355                1360
Gln Thr Phe Lys Val Ile Glu Glu Ala Val Tyr Phe His Gln His Ser
                1365                1370                1375
Ile Leu Ala Cys Lys Ile Glu Met Val Asp Tyr Lys Glu Glu Tyr Asn
            1380                1385                1390
Thr Thr Leu Pro Gln Phe Met Pro Tyr Glu Asp Gly Ile Tyr Ser Val
        1395                1400                1405
Ile Gln Lys Lys Val Thr Trp Tyr Glu Ala Leu Asn Met Cys Ser Gln
    1410                1415                1420
Ser Gly Gly His Leu Ala Ser Val His Asn Gln Asn Gly Gln Leu Phe
1425                1430                1435                1440
Leu Glu Asp Ile Val Lys Arg Asp Gly Phe Pro Leu Trp Val Gly Leu
                1445                1450                1455
Ser Ser His Asp Gly Ser Glu Ser Ser Phe Glu Trp Ser Asp Gly Ser
            1460                1465                1470
Thr Phe Asp Tyr Ile Pro Trp Lys Gly Gln Thr Ser Pro Gly Asn Cys
        1475                1480                1485
Val Leu Leu Asp Pro Lys Gly Thr Trp Lys His Glu Lys Cys Asn Ser
    1490                1495                1500
Val Lys Asp Gly Ala Ile Cys Tyr Lys Pro Thr Lys Ser Lys Lys Leu
1505                1510                1515                1520
Ser Arg Leu Thr Tyr Ser Ser Arg Cys Pro Ala Ala Lys Glu Asn Gly
                1525                1530                1535
Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp Gln Ala
            1540                1545                1550
Leu His Ser Phe Ser Glu Ala Lys Lys Leu Cys Ser Lys His Asp His
        1555                1560                1565
Ser Ala Thr Ile Val Ser Ile Lys Asp Glu Asp Glu Asn Lys Phe Val
    1570                1575                1580
Ser Arg Leu Met Arg Glu Asn Asn Asn Ile Thr Met Arg Val Trp Leu
1585                1590                1595                1600
Gly Leu Ser Gln His Ser Val Asp Gln Ser Trp Ser Trp Leu Asp Gly
                1605                1610                1615
Ser Glu Val Thr Phe Val Lys Trp Glu Asn Lys Ser Lys Ser Gly Val
            1620                1625                1630
Gly Arg Cys Ser Met Leu Ile Ala Ser Asn Glu Thr Trp Lys Lys Val
        1635                1640                1645
Glu Cys Glu His Gly Phe Gly Arg Val Val Cys Lys Val Pro Leu Gly
    1650                1655                1660
Pro Asp Tyr Thr Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu
1665                1670                1675                1680
Val Leu Met Gly Gly Leu Ile Trp Phe Leu Phe Gln Arg His Arg Leu
                1685                1690                1695
His Leu Ala Gly Phe Ser Ser Val Arg Tyr Ala Gln Gly Val Asn Glu
            1700                1705                1710
Asp Glu Ile Met Leu Pro Ser Phe His Asp
        1715                1720

<210> 674
<211> 185
<212> PRT
<213> Homo sapiens

<400> 674
Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly
 1               5                  10                  15
Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu
            20                  25                  30
Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser
        35                  40                  45
Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn
    50                  55                  60
Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn
65                  70                  75                  80
Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala
                85                  90                  95
Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly
            100                 105                 110
Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro
        115                 120                 125
Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser
    130                 135                 140
Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu
145                 150                 155                 160
Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro
                165                 170                 175
Ala Val Gln Arg Thr Leu Leu Glu Lys
            180                 185

<210> 675
<211> 185
<212> PRT
<213> Homo sapiens

<400> 675
Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly
 1               5                  10                  15
Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu
            20                  25                  30
Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser
        35                  40                  45
Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn
    50                  55                  60
Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn
65                  70                  75                  80
Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala
                85                  90                  95
Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly
            100                 105                 110
Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro
        115                 120                 125
Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser
    130                 135                 140
Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu
145                 150                 155                 160
Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro
                165                 170                 175
Ala Val Gln Arg Thr Leu Leu Glu Lys
            180                 185

<210> 676
<211> 185
<212> PRT
<213> Homo sapiens

<400> 676
Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly
 1               5                  10                  15
Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu
            20                  25                  30
Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser
        35                  40                  45
Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn
    50                  55                  60
Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn
65                  70                  75                  80
Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala
                85                  90                  95
Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly
            100                 105                 110
Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro
        115                 120                 125
Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser
    130                 135                 140
Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu
145                 150                 155                 160
Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro
                165                 170                 175
Ala Val Gln Arg Thr Leu Leu Glu Lys
            180                 185

<210> 677
<211> 185
<212> PRT
<213> Homo sapiens

<400> 677
Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly
 1               5                  10                  15
Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu
            20                  25                  30
Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser
        35                  40                  45
Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn
    50                  55                  60
Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn
65                  70                  75                  80
Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala
                85                  90                  95
Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly
            100                 105                 110
Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro
        115                 120                 125
Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser
    130                 135                 140
Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu
145                 150                 155                 160
Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro
                165                 170                 175
Ala Val Gln Arg Thr Leu Leu Glu Lys
            180                 185

<210> 678
<211> 185
<212> PRT
<213> Homo sapiens

<400> 678
Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly
 1               5                  10                  15
Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu
            20                  25                  30
Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser
        35                  40                  45
Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn
    50                  55                  60
Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn
65                  70                  75                  80
Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala
                85                  90                  95
Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly
            100                 105                 110
Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro
        115                 120                 125
Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser
    130                 135                 140
Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu
145                 150                 155                 160
Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro
                165                 170                 175
Ala Val Gln Arg Thr Leu Leu Glu Lys
            180                 185

<210> 679
<211> 195
<212> PRT
<213> Homo sapiens

<400> 679
Thr His Pro Asn Gln Ser Gln Ile Gln Thr Pro Ser Ser Leu Ile Pro
 1               5                  10                  15
Pro Gly Met Thr Leu Ile Ser Gln Met Phe Leu His Gly Glu Arg Asn
            20                  25                  30
Asn Gly Gly Phe Asp Leu Ser Asp Ala Leu Pro Asp Asn Glu Asn Lys
        35                  40                  45
Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser Ala Gly Asp Asp Phe Asp
    50                  55                  60
Leu Gly Asp Ala Val Val Asp Gly Glu Asn Asp Asp Pro Arg Pro Pro
65                  70                  75                  80
Asn Pro Pro Lys Pro Met Pro Asn Pro Asn Pro Asn His Pro Ser Ser
                85                  90                  95
Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala Asp Gly Val Ser Gly Gly
            100                 105                 110
Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly Ser His Arg Lys Glu Gly
        115                 120                 125
Glu Glu Ala Asp Ala Pro Gly Val Ile Pro Gly Ile Val Gly Ala Val
    130                 135                 140
Val Val Ala Val Ala Gly Ala Ile Ser Ser Phe Ile Ala Tyr Gln Lys
145                 150                 155                 160
Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu Gln Gly Glu Val Asp Met
                165                 170                 175
Glu Ser His Arg Asn Ala Asn Ala Glu Pro Ala Val Gln Arg Thr Leu
            180                 185                 190
Leu Glu Lys
        195

<210> 680
<211> 185
<212> PRT
<213> Homo sapiens

<400> 680
Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly
 1               5                  10                  15
Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu
            20                  25                  30
Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser
        35                  40                  45
Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn
    50                  55                  60
Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn
65                  70                  75                  80
Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala
                85                  90                  95
Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly
            100                 105                 110
Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro
        115                 120                 125
Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser
    130                 135                 140
Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu
145                 150                 155                 160
Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro
                165                 170                 175
Ala Val Gln Arg Thr Leu Leu Glu Lys
            180                 185

<210> 681
<211> 185
<212> PRT
<213> Homo sapiens

<400> 681
Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly
 1               5                  10                  15
Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu
            20                  25                  30
Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser
        35                  40                  45
Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn
    50                  55                  60
Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn
65                  70                  75                  80
Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala
                85                  90                  95
Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly
            100                 105                 110
Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro
        115                 120                 125
Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser
    130                 135                 140
Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu
145                 150                 155                 160
Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro
                165                 170                 175
Ala Val Gln Arg Thr Leu Leu Glu Lys
            180                 185

<210> 682
<211> 760
<212> PRT
<213> Homo sapiens

<400> 682
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95
Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro
            100                 105                 110
Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys
        115                 120                 125
Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile
    130                 135                 140
Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln
145                 150                 155                 160
Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe
                165                 170                 175
Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val
            180                 185                 190
Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg
        195                 200                 205
Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys
    210                 215                 220
Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys
225                 230                 235                 240
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
                245                 250                 255
Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu
            260                 265                 270
Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe
        275                 280                 285
Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly
    290                 295                 300
Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln
305                 310                 315                 320
Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr
                325                 330                 335
Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp
            340                 345                 350
Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser
        355                 360                 365
Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile
    370                 375                 380
Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp
385                 390                 395                 400
His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala
                405                 410                 415
Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met
            420                 425                 430
Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile
        435                 440                 445
Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr
    450                 455                 460
Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr
465                 470                 475                 480
Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val
                485                 490                 495
Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn
            500                 505                 510
Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp
        515                 520                 525
Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe
    530                 535                 540
Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp
545                 550                 555                 560
Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu
                565                 570                 575
Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu
            580                 585                 590
Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn
        595                 600                 605
Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp
    610                 615                 620
Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln
625                 630                 635                 640
Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu
                645                 650                 655
Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys
            660                 665                 670
Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro
        675                 680                 685
Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser
    690                 695                 700
Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys
705                 710                 715                 720
Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala
                725                 730                 735
Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp
            740                 745                 750
Val Trp Asp Ile Asp Asn Glu Phe
        755                 760

<210> 683
<211> 760
<212> PRT
<213> Homo sapiens

<400> 683
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95
Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro
            100                 105                 110
Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys
        115                 120                 125
Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile
    130                 135                 140
Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln
145                 150                 155                 160
Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe
                165                 170                 175
Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val
            180                 185                 190
Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg
        195                 200                 205
Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys
    210                 215                 220
Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys
225                 230                 235                 240
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
                245                 250                 255
Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu
            260                 265                 270
Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe
        275                 280                 285
Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly
    290                 295                 300
Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln
305                 310                 315                 320
Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr
                325                 330                 335
Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp
            340                 345                 350
Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser
        355                 360                 365
Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile
    370                 375                 380
Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp
385                 390                 395                 400
His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala
                405                 410                 415
Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met
            420                 425                 430
Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile
        435                 440                 445
Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr
    450                 455                 460
Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr
465                 470                 475                 480
Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val
                485                 490                 495
Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn
            500                 505                 510
Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp
        515                 520                 525
Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe
    530                 535                 540
Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp
545                 550                 555                 560
Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu
                565                 570                 575
Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu
            580                 585                 590
Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn
        595                 600                 605
Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp
    610                 615                 620
Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln
625                 630                 635                 640
Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu
                645                 650                 655
Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys
            660                 665                 670
Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro
        675                 680                 685
Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser
    690                 695                 700
Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys
705                 710                 715                 720
Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala
                725                 730                 735
Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp
            740                 745                 750
Val Trp Asp Ile Asp Asn Glu Phe
        755                 760

<210> 684
<211> 760
<212> PRT
<213> Homo sapiens

<400> 684
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95
Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro
            100                 105                 110
Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys
        115                 120                 125
Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile
    130                 135                 140
Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln
145                 150                 155                 160
Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe
                165                 170                 175
Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val
            180                 185                 190
Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg
        195                 200                 205
Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys
    210                 215                 220
Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys
225                 230                 235                 240
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
                245                 250                 255
Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu
            260                 265                 270
Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe
        275                 280                 285
Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly
    290                 295                 300
Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln
305                 310                 315                 320
Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr
                325                 330                 335
Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp
            340                 345                 350
Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser
        355                 360                 365
Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile
    370                 375                 380
Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp
385                 390                 395                 400
His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala
                405                 410                 415
Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met
            420                 425                 430
Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile
        435                 440                 445
Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr
    450                 455                 460
Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr
465                 470                 475                 480
Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val
                485                 490                 495
Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn
            500                 505                 510
Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp
        515                 520                 525
Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe
    530                 535                 540
Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp
545                 550                 555                 560
Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu
                565                 570                 575
Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu
            580                 585                 590
Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn
        595                 600                 605
Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp
    610                 615                 620
Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln
625                 630                 635                 640
Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu
                645                 650                 655
Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys
            660                 665                 670
Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro
        675                 680                 685
Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser
    690                 695                 700
Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys
705                 710                 715                 720
Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala
                725                 730                 735
Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp
            740                 745                 750
Val Trp Asp Ile Asp Asn Glu Phe
        755                 760

<210> 685
<211> 760
<212> PRT
<213> Homo sapiens

<400> 685
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95
Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro
            100                 105                 110
Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys
        115                 120                 125
Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile
    130                 135                 140
Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln
145                 150                 155                 160
Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe
                165                 170                 175
Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val
            180                 185                 190
Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg
        195                 200                 205
Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys
    210                 215                 220
Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys
225                 230                 235                 240
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
                245                 250                 255
Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu
            260                 265                 270
Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe
        275                 280                 285
Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly
    290                 295                 300
Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln
305                 310                 315                 320
Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr
                325                 330                 335
Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp
            340                 345                 350
Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser
        355                 360                 365
Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile
    370                 375                 380
Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp
385                 390                 395                 400
His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala
                405                 410                 415
Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met
            420                 425                 430
Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile
        435                 440                 445
Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr
    450                 455                 460
Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr
465                 470                 475                 480
Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val
                485                 490                 495
Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn
            500                 505                 510
Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp
        515                 520                 525
Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe
    530                 535                 540
Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp
545                 550                 555                 560
Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu
                565                 570                 575
Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu
            580                 585                 590
Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn
        595                 600                 605
Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp
    610                 615                 620
Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln
625                 630                 635                 640
Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu
                645                 650                 655
Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys
            660                 665                 670
Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro
        675                 680                 685
Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser
    690                 695                 700
Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys
705                 710                 715                 720
Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala
                725                 730                 735
Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp
            740                 745                 750
Val Trp Asp Ile Asp Asn Glu Phe
        755                 760

<210> 686
<211> 760
<212> PRT
<213> Homo sapiens

<400> 686
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95
Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro
            100                 105                 110
Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys
        115                 120                 125
Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile
    130                 135                 140
Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln
145                 150                 155                 160
Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe
                165                 170                 175
Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val
            180                 185                 190
Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg
        195                 200                 205
Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys
    210                 215                 220
Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys
225                 230                 235                 240
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
                245                 250                 255
Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu
            260                 265                 270
Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe
        275                 280                 285
Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly
    290                 295                 300
Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln
305                 310                 315                 320
Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr
                325                 330                 335
Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp
            340                 345                 350
Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser
        355                 360                 365
Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile
    370                 375                 380
Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp
385                 390                 395                 400
His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala
                405                 410                 415
Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met
            420                 425                 430
Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile
        435                 440                 445
Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr
    450                 455                 460
Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr
465                 470                 475                 480
Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val
                485                 490                 495
Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn
            500                 505                 510
Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp
        515                 520                 525
Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe
    530                 535                 540
Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp
545                 550                 555                 560
Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu
                565                 570                 575
Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu
            580                 585                 590
Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn
        595                 600                 605
Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp
    610                 615                 620
Leu Asn Gly Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln
625                 630                 635                 640
Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu
                645                 650                 655
Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys
            660                 665                 670
Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro
        675                 680                 685
Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser
    690                 695                 700
Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys
705                 710                 715                 720
Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala
                725                 730                 735
Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp
            740                 745                 750
Val Trp Asp Ile Asp Asn Glu Phe
        755                 760

<210> 687
<211> 760
<212> PRT
<213> Homo sapiens

<400> 687
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95
Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro
            100                 105                 110
Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys
        115                 120                 125
Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile
    130                 135                 140
Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln
145                 150                 155                 160
Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe
                165                 170                 175
Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val
            180                 185                 190
Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg
        195                 200                 205
Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys
    210                 215                 220
Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys
225                 230                 235                 240
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
                245                 250                 255
Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu
            260                 265                 270
Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe
        275                 280                 285
Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly
    290                 295                 300
Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln
305                 310                 315                 320
Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr
                325                 330                 335
Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp
            340                 345                 350
Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser
        355                 360                 365
Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile
    370                 375                 380
Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp
385                 390                 395                 400
His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala
                405                 410                 415
Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met
            420                 425                 430
Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile
        435                 440                 445
Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr
    450                 455                 460
Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr
465                 470                 475                 480
Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val
                485                 490                 495
Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn
            500                 505                 510
Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp
        515                 520                 525
Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe
    530                 535                 540
Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp
545                 550                 555                 560
Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu
                565                 570                 575
Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu
            580                 585                 590
Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn
        595                 600                 605
Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp
    610                 615                 620
Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln
625                 630                 635                 640
Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu
                645                 650                 655
Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys
            660                 665                 670
Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro
        675                 680                 685
Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser
    690                 695                 700
Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys
705                 710                 715                 720
Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala
                725                 730                 735
Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp
            740                 745                 750
Val Trp Asp Ile Asp Asn Glu Phe
        755                 760

<210> 688
<211> 760
<212> PRT
<213> Homo sapiens

<400> 688
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95
Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro
            100                 105                 110
Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys
        115                 120                 125
Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile
    130                 135                 140
Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln
145                 150                 155                 160
Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe
                165                 170                 175
Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val
            180                 185                 190
Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg
        195                 200                 205
Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys
    210                 215                 220
Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys
225                 230                 235                 240
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
                245                 250                 255
Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu
            260                 265                 270
Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe
        275                 280                 285
Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly
    290                 295                 300
Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln
305                 310                 315                 320
Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr
                325                 330                 335
Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp
            340                 345                 350
Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser
        355                 360                 365
Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile
    370                 375                 380
Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp
385                 390                 395                 400
His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala
                405                 410                 415
Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met
            420                 425                 430
Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile
        435                 440                 445
Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr
    450                 455                 460
Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr
465                 470                 475                 480
Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val
                485                 490                 495
Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn
            500                 505                 510
Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp
        515                 520                 525
Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe
    530                 535                 540
Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp
545                 550                 555                 560
Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu
                565                 570                 575
Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu
            580                 585                 590
Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn
        595                 600                 605
Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp
    610                 615                 620
Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln
625                 630                 635                 640
Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu
                645                 650                 655
Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys
            660                 665                 670
Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro
        675                 680                 685
Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser
    690                 695                 700
Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys
705                 710                 715                 720
Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala
                725                 730                 735
Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp
            740                 745                 750
Val Trp Asp Ile Asp Asn Glu Phe
        755                 760

<210> 689
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 689
Met Phe Pro Thr Glu Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15
Gly Pro Glu Ala Ala Val Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg
                85                  90                  95
Cys Arg Ile Gly Lys Asn Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu
            100                 105                 110
Gly Ser Pro Asn Gly Glu Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg
        115                 120                 125
Asp Asn Gln Trp Leu Gly Val Thr Leu Ser Arg Gln Pro Gly Glu Asn
    130                 135                 140
Gly Ser Ile Val Thr Cys Gly His Arg Trp Lys Asn Ile Phe Tyr Ile
145                 150                 155                 160
Lys Asn Glu Asn Lys Leu Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro
                165                 170                 175
Asp Leu Arg Thr Glu Leu Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp
            180                 185                 190
Tyr Val Lys Lys Phe Gly Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile
        195                 200                 205
Ser Ser Phe Tyr Thr Lys Asp Leu Ile Val Met Gly Ala Pro Gly Ser
    210                 215                 220
Ser Tyr Trp Thr Gly Ser Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys
225                 230                 235                 240
Tyr Lys Ala Phe Leu Asp Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr
                245                 250                 255
Leu Gly Tyr Ser Val Gly Ala Gly His Phe Arg Ser Gln His Thr Thr
            260                 265                 270
Glu Val Val Gly Gly Ala Pro Gln His Glu Gln Ile Gly Lys Ala Tyr
        275                 280                 285
Ile Phe Ser Ile Asp Glu Lys Glu Leu Asn Ile Leu His Glu Met Lys
    290                 295                 300
Gly Lys Lys Leu Gly Ser Tyr Phe Gly Ala Ser Val Cys Ala Val Asp
305                 310                 315                 320
Leu Asn Ala Asp Gly Phe Ser Asp Leu Leu Val Gly Ala Pro Met Gln
                325                 330                 335
Ser Thr Ile Arg Glu Glu Gly Arg Val Phe Val Tyr Ile Asn Ser Gly
            340                 345                 350
Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Val Gly Ser Asp
        355                 360                 365
Lys Tyr Ala Ala Arg Phe Gly Glu Ser Ile Val Asn Leu Gly Asp Ile
    370                 375                 380
Asp Asn Asp Gly Phe Glu Asp Val Ala Ile Gly Ala Pro Gln Glu Asp
385                 390                 395                 400
Asp Leu Gln Gly Ala Ile Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile
                405                 410                 415
Ser Ser Thr Phe Ser Gln Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser
            420                 425                 430
Leu Ser Met Phe Gly Gln Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn
        435                 440                 445
Asn Gly Tyr Val Asp Val Ala Val Gly Ala Phe Arg Ser Asp Ser Ala
    450                 455                 460
Val Leu Leu Arg Thr Arg Pro Val Val Ile Val Asp Ala Ser Leu Ser
465                 470                 475                 480
His Pro Glu Ser Val Asn Arg Thr Lys Phe Asp Cys Val Glu Asn Gly
                485                 490                 495
Trp Pro Ser Val Cys Ile Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly
            500                 505                 510
Lys Glu Val Pro Gly Tyr Ile Val Leu Phe Tyr Asn Met Ser Leu Asp
        515                 520                 525
Val Asn Arg Lys Ala Glu Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn
    530                 535                 540
Gly Thr Ser Asp Val Ile Thr Gly Ser Ile Gln Val Ser Ser Arg Glu
545                 550                 555                 560
Ala Asn Cys Arg Thr His Gln Ala Phe Met Arg Lys Asp Val Arg Asp
                565                 570                 575
Ile Leu Thr Pro Ile Gln Ile Glu Ala Ala Tyr His Leu Gly Pro His
            580                 585                 590
Val Ile Ser Lys Arg Ser Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile
        595                 600                 605
Leu Gln Gln Lys Lys Glu Lys Asp Ile Met Lys Lys Thr Ile Asn Phe
    610                 615                 620
Ala Arg Phe Cys Ala His Glu Asn Cys Ser Ala Asp Leu Gln Val Ser
625                 630                 635                 640
Ala Lys Ile Gly Phe Leu Lys Pro His Glu Asn Lys Thr Tyr Leu Ala
                645                 650                 655
Val Gly Ser Met Lys Thr Leu Met Leu Asn Val Ser Leu Phe Asn Ala
            660                 665                 670
Gly Asp Asp Ala Tyr Glu Thr Thr Leu His Val Lys Leu Pro Val Gly
        675                 680                 685
Leu Tyr Phe Ile Lys Ile Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys
    690                 695                 700
Glu Val Thr Asp Asn Ser Gly Val Val Gln Leu Asp Cys Ser Ile Gly
705                 710                 715                 720
Tyr Ile Tyr Val Asp His Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu
                725                 730                 735
Asp Val Ser Ser Leu Ser Arg Ala Glu Glu Asp Leu Ser Ile Thr Val
            740                 745                 750
His Ala Thr Cys Glu Asn Glu Glu Glu Met Asp Asn Leu Lys His Ser
        755                 760                 765
Arg Val Thr Val Ala Ile Pro Leu Lys Tyr Glu Val Lys Leu Thr Val
    770                 775                 780
His Gly Phe Val Asn Pro Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu
785                 790                 795                 800
Asn Glu Pro Glu Thr Cys Met Val Glu Lys Met Asn Leu Thr Phe His
                805                 810                 815
Val Ile Asn Thr Gly Asn Ser Met Ala Pro Asn Val Ser Val Glu Ile
            820                 825                 830
Met Val Pro Asn Ser Phe Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile
        835                 840                 845
Leu Asp Val Gln Thr Thr Thr Gly Glu Cys His Phe Glu Asn Tyr Gln
    850                 855                 860
Arg Val Cys Ala Leu Glu Gln Gln Lys Ser Ala Met Gln Thr Leu Lys
865                 870                 875                 880
Gly Ile Val Arg Phe Leu Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys
                885                 890                 895
Ile Lys Ala Asp Pro His Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys
            900                 905                 910
Met Glu Ser Gly Lys Glu Ala Ser Val His Ile Gln Leu Glu Gly Arg
        915                 920                 925
Pro Ser Ile Leu Glu Met Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile
    930                 935                 940
Arg Ala Thr Gly Phe Pro Glu Pro Asn Pro Arg Val Ile Glu Leu Asn
945                 950                 955                 960
Lys Asp Glu Asn Val Ala His Val Leu Leu Glu Gly Leu His His Gln
                965                 970                 975
Arg Pro Lys Arg Tyr Phe Thr Ile Val Ile Ile Ser Ser Ser Leu Leu
            980                 985                 990
Leu Gly Leu Ile Val Leu Leu Leu Ile Ser Tyr Val Met Trp Lys Ala
        995                 1000                1005
Gly Phe Phe Lys Arg Gln Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg
    1010                1015                1020
Arg Asp Ser Trp Ser Tyr Ile Asn Ser Lys Ser Asn Asp Asp
1025                1030                1035

<210> 690
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 690
Met Phe Pro Thr Glu Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15
Gly Pro Glu Ala Ala Val Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg
                85                  90                  95
Cys Arg Ile Gly Lys Asn Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu
            100                 105                 110
Gly Ser Pro Asn Gly Glu Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg
        115                 120                 125
Asp Asn Gln Trp Leu Gly Val Thr Leu Ser Arg Gln Pro Gly Glu Asn
    130                 135                 140
Gly Ser Ile Val Thr Cys Gly His Arg Trp Lys Asn Ile Phe Tyr Ile
145                 150                 155                 160
Lys Asn Glu Asn Lys Leu Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro
                165                 170                 175
Asp Leu Arg Thr Glu Leu Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp
            180                 185                 190
Tyr Val Lys Lys Phe Gly Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile
        195                 200                 205
Ser Ser Phe Tyr Thr Lys Asp Leu Ile Val Met Gly Ala Pro Gly Ser
    210                 215                 220
Ser Tyr Trp Thr Gly Ser Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys
225                 230                 235                 240
Tyr Lys Ala Phe Leu Asp Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr
                245                 250                 255
Leu Gly Tyr Ser Val Gly Ala Gly His Phe Arg Ser Gln His Thr Thr
            260                 265                 270
Glu Val Val Gly Gly Ala Pro Gln His Glu Gln Ile Gly Lys Ala Tyr
        275                 280                 285
Ile Phe Ser Ile Asp Glu Lys Glu Leu Asn Ile Leu His Glu Met Lys
    290                 295                 300
Gly Lys Lys Leu Gly Ser Tyr Phe Gly Ala Ser Val Cys Ala Val Asp
305                 310                 315                 320
Leu Asn Ala Asp Gly Phe Ser Asp Leu Leu Val Gly Ala Pro Met Gln
                325                 330                 335
Ser Thr Ile Arg Glu Glu Gly Arg Val Phe Val Tyr Ile Asn Ser Gly
            340                 345                 350
Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Val Gly Ser Asp
        355                 360                 365
Lys Tyr Ala Ala Arg Phe Gly Glu Ser Ile Val Asn Leu Gly Asp Ile
    370                 375                 380
Asp Asn Asp Gly Phe Glu Asp Val Ala Ile Gly Ala Pro Gln Glu Asp
385                 390                 395                 400
Asp Leu Gln Gly Ala Ile Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile
                405                 410                 415
Ser Ser Thr Phe Ser Gln Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser
            420                 425                 430
Leu Ser Met Phe Gly Gln Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn
        435                 440                 445
Asn Gly Tyr Val Asp Val Ala Val Gly Ala Phe Arg Ser Asp Ser Ala
    450                 455                 460
Val Leu Leu Arg Thr Arg Pro Val Val Ile Val Asp Ala Ser Leu Ser
465                 470                 475                 480
His Pro Glu Ser Val Asn Arg Thr Lys Phe Asp Cys Val Glu Asn Gly
                485                 490                 495
Trp Pro Ser Val Cys Ile Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly
            500                 505                 510
Lys Glu Val Pro Gly Tyr Ile Val Leu Phe Tyr Asn Met Ser Leu Asp
        515                 520                 525
Val Asn Arg Lys Ala Glu Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn
    530                 535                 540
Gly Thr Ser Asp Val Ile Thr Gly Ser Ile Gln Val Ser Ser Arg Glu
545                 550                 555                 560
Ala Asn Cys Arg Thr His Gln Ala Phe Met Arg Lys Asp Val Arg Asp
                565                 570                 575
Ile Leu Thr Pro Ile Gln Ile Glu Ala Ala Tyr His Leu Gly Pro His
            580                 585                 590
Val Ile Ser Lys Arg Ser Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile
        595                 600                 605
Leu Gln Gln Lys Lys Glu Lys Asp Ile Met Lys Lys Thr Ile Asn Phe
    610                 615                 620
Ala Arg Phe Cys Ala His Glu Asn Cys Ser Ala Asp Leu Gln Val Ser
625                 630                 635                 640
Ala Lys Ile Gly Phe Leu Lys Pro His Glu Asn Lys Thr Tyr Leu Ala
                645                 650                 655
Val Gly Ser Met Lys Thr Leu Met Leu Asn Val Ser Leu Phe Asn Ala
            660                 665                 670
Gly Asp Asp Ala Tyr Glu Thr Thr Leu His Val Lys Leu Pro Val Gly
        675                 680                 685
Leu Tyr Phe Ile Lys Ile Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys
    690                 695                 700
Glu Val Thr Asp Asn Ser Gly Val Val Gln Leu Asp Cys Ser Ile Gly
705                 710                 715                 720
Tyr Ile Tyr Val Asp His Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu
                725                 730                 735
Asp Val Ser Ser Leu Ser Arg Ala Glu Glu Asp Leu Ser Ile Thr Val
            740                 745                 750
His Ala Thr Cys Glu Asn Glu Glu Glu Met Asp Asn Leu Lys His Ser
        755                 760                 765
Arg Val Thr Val Ala Ile Pro Leu Lys Tyr Glu Val Lys Leu Thr Val
    770                 775                 780
His Gly Phe Val Asn Pro Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu
785                 790                 795                 800
Asn Glu Pro Glu Thr Cys Met Val Glu Lys Met Asn Leu Thr Phe His
                805                 810                 815
Val Ile Asn Thr Gly Asn Ser Met Ala Pro Asn Val Ser Val Glu Ile
            820                 825                 830
Met Val Pro Asn Ser Phe Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile
        835                 840                 845
Leu Asp Val Gln Thr Thr Thr Gly Glu Cys His Phe Glu Asn Tyr Gln
    850                 855                 860
Arg Val Cys Ala Leu Glu Gln Gln Lys Ser Ala Met Gln Thr Leu Lys
865                 870                 875                 880
Gly Ile Val Gln Phe Leu Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys
                885                 890                 895
Ile Lys Ala Asp Pro His Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys
            900                 905                 910
Met Glu Ser Gly Lys Glu Ala Ser Val His Ile Gln Leu Glu Gly Arg
        915                 920                 925
Pro Ser Ile Leu Glu Met Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile
    930                 935                 940
Arg Ala Thr Gly Phe Pro Glu Pro Asn Pro Arg Val Ile Glu Leu Asn
945                 950                 955                 960
Lys Asp Glu Asn Val Ala His Val Leu Leu Glu Gly Leu His His Gln
                965                 970                 975
Arg Pro Lys Arg Tyr Phe Thr Ile Val Ile Ile Ser Ser Ser Leu Leu
            980                 985                 990
Leu Gly Leu Ile Val Leu Leu Leu Ile Ser Tyr Val Met Trp Lys Ala
        995                 1000                1005
Gly Phe Phe Lys Arg Gln Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg
    1010                1015                1020
Arg Asp Ser Trp Ser Tyr Ile Asn Ser Lys Ser Asn Asp Asp
1025                1030                1035

<210> 691
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 691
Met Phe Pro Thr Glu Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15
Gly Pro Glu Ala Ala Val Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg
                85                  90                  95
Cys Arg Ile Gly Lys Asn Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu
            100                 105                 110
Gly Ser Pro Asn Gly Glu Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg
        115                 120                 125
Asp Asn Gln Trp Leu Gly Val Thr Leu Ser Arg Gln Pro Gly Glu Asn
    130                 135                 140
Gly Ser Ile Val Thr Cys Gly His Arg Trp Lys Asn Ile Phe Tyr Ile
145                 150                 155                 160
Lys Asn Glu Asn Lys Leu Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro
                165                 170                 175
Asp Leu Arg Thr Glu Leu Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp
            180                 185                 190
Tyr Val Lys Lys Phe Gly Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile
        195                 200                 205
Ser Ser Phe Tyr Thr Lys Asp Leu Ile Val Met Gly Ala Pro Gly Ser
    210                 215                 220
Ser Tyr Trp Thr Gly Ser Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys
225                 230                 235                 240
Tyr Lys Ala Phe Leu Asp Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr
                245                 250                 255
Leu Gly Tyr Ser Val Gly Ala Gly His Phe Arg Ser Gln His Thr Thr
            260                 265                 270
Glu Val Val Gly Gly Ala Pro Gln His Glu Gln Ile Gly Lys Ala Tyr
        275                 280                 285
Ile Phe Ser Ile Asp Glu Lys Glu Leu Asn Ile Leu His Glu Met Lys
    290                 295                 300
Gly Lys Lys Leu Gly Ser Tyr Phe Gly Ala Ser Val Cys Ala Val Asp
305                 310                 315                 320
Leu Asn Ala Asp Gly Phe Ser Asp Leu Leu Val Gly Ala Pro Met Gln
                325                 330                 335
Ser Thr Ile Arg Glu Glu Gly Arg Val Phe Val Tyr Ile Asn Ser Gly
            340                 345                 350
Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Val Gly Ser Asp
        355                 360                 365
Lys Tyr Ala Ala Arg Phe Gly Glu Ser Ile Val Asn Leu Gly Asp Ile
    370                 375                 380
Asp Asn Asp Gly Phe Glu Asp Val Ala Ile Gly Ala Pro Gln Glu Asp
385                 390                 395                 400
Asp Leu Gln Gly Ala Ile Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile
                405                 410                 415
Ser Ser Thr Phe Ser Gln Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser
            420                 425                 430
Leu Ser Met Phe Gly Gln Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn
        435                 440                 445
Asn Gly Tyr Val Asp Val Ala Val Gly Ala Phe Arg Ser Asp Ser Ala
    450                 455                 460
Val Leu Leu Arg Thr Arg Pro Val Val Ile Val Asp Ala Ser Leu Ser
465                 470                 475                 480
His Pro Glu Ser Val Asn Arg Thr Lys Phe Asp Cys Val Glu Asn Gly
                485                 490                 495
Trp Pro Ser Val Cys Ile Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly
            500                 505                 510
Lys Glu Val Pro Gly Tyr Ile Val Leu Phe Tyr Asn Met Ser Leu Asp
        515                 520                 525
Val Asn Arg Lys Ala Glu Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn
    530                 535                 540
Gly Thr Ser Asp Val Ile Thr Gly Ser Ile Gln Val Ser Ser Arg Glu
545                 550                 555                 560
Ala Asn Cys Arg Thr His Gln Ala Phe Met Arg Lys Asp Val Arg Asp
                565                 570                 575
Ile Leu Thr Pro Ile Gln Ile Glu Ala Ala Tyr His Leu Gly Pro His
            580                 585                 590
Val Ile Ser Lys Arg Ser Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile
        595                 600                 605
Leu Gln Gln Lys Lys Glu Lys Asp Ile Met Lys Lys Thr Ile Asn Phe
    610                 615                 620
Ala Arg Phe Cys Ala His Glu Asn Cys Ser Ala Asp Leu Gln Val Ser
625                 630                 635                 640
Ala Lys Ile Gly Phe Leu Lys Pro His Glu Asn Lys Thr Tyr Leu Ala
                645                 650                 655
Val Gly Ser Met Lys Thr Leu Met Leu Asn Val Ser Leu Phe Asn Ala
            660                 665                 670
Gly Asp Asp Ala Tyr Glu Thr Thr Leu His Val Lys Leu Pro Val Gly
        675                 680                 685
Leu Tyr Phe Ile Lys Ile Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys
    690                 695                 700
Glu Val Thr Asp Asn Ser Gly Val Val Gln Leu Asp Cys Ser Ile Gly
705                 710                 715                 720
Tyr Ile Tyr Val Asp His Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu
                725                 730                 735
Asp Val Ser Ser Leu Ser Arg Ala Glu Glu Asp Leu Ser Ile Thr Val
            740                 745                 750
His Ala Thr Cys Glu Asn Glu Glu Glu Met Asp Asn Leu Lys His Ser
        755                 760                 765
Arg Val Thr Val Ala Ile Pro Leu Lys Tyr Glu Val Lys Leu Thr Val
    770                 775                 780
His Gly Phe Val Asn Pro Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu
785                 790                 795                 800
Asn Glu Pro Glu Thr Cys Met Val Glu Lys Met Asn Leu Thr Phe His
                805                 810                 815
Val Ile Asn Thr Gly Asn Ser Met Ala Pro Asn Val Ser Val Glu Ile
            820                 825                 830
Met Val Pro Asn Ser Phe Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile
        835                 840                 845
Leu Asp Val Gln Thr Thr Thr Gly Glu Cys His Phe Glu Asn Tyr Gln
    850                 855                 860
Arg Val Cys Ala Leu Glu Gln Gln Lys Ser Ala Met Gln Thr Leu Lys
865                 870                 875                 880
Gly Ile Val Gln Phe Leu Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys
                885                 890                 895
Ile Lys Ala Asp Pro His Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys
            900                 905                 910
Met Glu Ser Gly Lys Glu Ala Ser Val His Ile Gln Leu Glu Gly Arg
        915                 920                 925
Pro Ser Ile Leu Glu Met Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile
    930                 935                 940
Arg Ala Thr Gly Phe Pro Glu Pro Asn Pro Arg Val Ile Glu Leu Asn
945                 950                 955                 960
Lys Asp Glu Asn Val Ala His Val Leu Leu Glu Gly Leu His His Gln
                965                 970                 975
Arg Pro Lys Arg Tyr Phe Thr Ile Val Ile Ile Ser Ser Ser Leu Leu
            980                 985                 990
Leu Gly Leu Ile Val Leu Leu Leu Ile Ser Tyr Val Met Trp Lys Ala
        995                 1000                1005
Gly Phe Phe Lys Arg Gln Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg
    1010                1015                1020
Arg Asp Ser Trp Ser Tyr Ile Asn Ser Lys Ser Asn Asp Asp
1025                1030                1035

<210> 692
<211> 135
<212> PRT
<213> Homo sapiens

<400> 692
Met Gln Leu Lys Arg Ala Asn Pro Gly Pro Arg Arg Ala Pro Val Arg
 1               5                  10                  15
Glu Thr Val Met Leu Leu Leu Cys Trp Gly Val Pro Pro Gly Arg Pro
            20                  25                  30
Tyr Lys Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His Asn
        35                  40                  45
Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn Arg
    50                  55                  60
Trp Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala Ser Val Ile Asn
65                  70                  75                  80
Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn Pro Gly Gln Thr
                85                  90                  95
Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu Pro Cys Gly Lys
            100                 105                 110
Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly Val Thr Leu Ser
        115                 120                 125
Arg Gln Pro Gly Glu Asn Gly
    130                 135

<210> 693
<211> 1218
<212> PRT
<213> Homo sapiens

<400> 693
Met Phe Pro Thr Asp Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15
Gly Pro Glu Ala Ala Leu Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg
                85                  90                  95
Cys Arg Ile Gly Lys Asn Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu
            100                 105                 110
Gly Ser Pro Asn Gly Glu Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg
        115                 120                 125
Asp Asn Gln Trp Leu Gly Val Thr Leu Ser Arg Gln Pro Gly Glu Asn
    130                 135                 140
Gly Ser Ile Val Thr Cys Gly His Arg Trp Lys Asn Ile Phe Tyr Ile
145                 150                 155                 160
Lys Asn Glu Asn Lys Leu Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro
                165                 170                 175
Asp Leu Arg Thr Glu Leu Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp
            180                 185                 190
Tyr Val Lys Lys Phe Gly Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile
        195                 200                 205
Ser Ser Phe Tyr Thr Lys Asp Leu Ile Val Met Gly Ala Pro Gly Ser
    210                 215                 220
Ser Tyr Trp Thr Gly Ser Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys
225                 230                 235                 240
Tyr Lys Ala Phe Leu Asp Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr
                245                 250                 255
Leu Gly Tyr Ser Val Gly Ala Gly His Phe Arg Ser Gln His Thr Thr
            260                 265                 270
Glu Val Val Gly Gly Ala Pro Gln His Glu Gln Ile Gly Lys Ala Tyr
        275                 280                 285
Ile Phe Ser Ile Asp Glu Lys Glu Leu Asn Ile Leu His Glu Met Lys
    290                 295                 300
Gly Lys Lys Leu Gly Ser Tyr Phe Gly Ala Ser Val Cys Ala Val Asp
305                 310                 315                 320
Leu Asn Ala Asp Gly Phe Ser Asp Leu Leu Val Gly Ala Pro Met Gln
                325                 330                 335
Ser Thr Ile Arg Glu Glu Gly Arg Val Phe Val Tyr Ile Asn Ser Gly
            340                 345                 350
Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Val Gly Ser Asp
        355                 360                 365
Lys Tyr Ala Ala Arg Phe Gly Glu Ser Ile Val Asn Leu Gly Asp Ile
    370                 375                 380
Asp Asn Asp Gly Phe Glu Asp Val Ala Ile Gly Ala Pro Gln Glu Asp
385                 390                 395                 400
Asp Leu Gln Gly Ala Ile Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile
                405                 410                 415
Ser Ser Thr Phe Ser Gln Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser
            420                 425                 430
Leu Ser Met Phe Gly Gln Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn
        435                 440                 445
Asn Gly Tyr Val Asp Val Ala Val Gly Ala Phe Arg Ser Asp Ser Ala
    450                 455                 460
Val Leu Leu Arg Thr Arg Pro Val Val Ile Val Asp Ala Ser Leu Ser
465                 470                 475                 480
His Pro Glu Ser Val Asn Arg Thr Lys Phe Asp Cys Val Glu Asn Gly
                485                 490                 495
Trp Pro Ser Val Cys Ile Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly
            500                 505                 510
Lys Glu Val Pro Gly Tyr Ile Val Leu Phe Tyr Asn Met Ser Leu Asp
        515                 520                 525
Val Asn Arg Lys Ala Glu Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn
    530                 535                 540
Gly Thr Ser Asp Val Ile Thr Gly Ser Ile Gln Val Ser Ser Arg Glu
545                 550                 555                 560
Ala Asn Cys Arg Thr His Gln Ala Phe Met Arg Lys Asp Val Arg Asp
                565                 570                 575
Ile Leu Thr Pro Ile Gln Ile Glu Ala Ala Tyr His Leu Gly Pro His
            580                 585                 590
Val Ile Ser Lys Arg Ser Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile
        595                 600                 605
Leu Gln Gln Lys Lys Glu Lys Asp Ile Met Lys Lys Thr Ile Asn Phe
    610                 615                 620
Ala Arg Phe Cys Ala His Glu Asn Cys Ser Ala Asp Leu Gln Val Ser
625                 630                 635                 640
Ala Lys Ile Gly Phe Leu Lys Pro His Glu Asn Lys Thr Tyr Leu Ala
                645                 650                 655
Val Gly Ser Met Lys Thr Leu Met Leu Asn Val Ser Leu Phe Asn Ala
            660                 665                 670
Gly Asp Asp Ala Tyr Glu Thr Thr Leu His Val Lys Leu Pro Val Gly
        675                 680                 685
Leu Tyr Phe Ile Lys Ile Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys
    690                 695                 700
Glu Val Thr Asp Asn Ser Gly Val Val Gln Leu Asp Cys Ser Ile Gly
705                 710                 715                 720
Tyr Ile Tyr Val Asp His Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu
                725                 730                 735
Asp Val Ser Ser Leu Ser Arg Ala Glu Glu Asp Leu Ser Ile Thr Val
            740                 745                 750
His Ala Thr Cys Glu Asn Glu Glu Glu Met Asp Asn Leu Lys His Ser
        755                 760                 765
Arg Val Thr Val Ala Ile Pro Leu Lys Tyr Glu Val Lys Leu Thr Val
    770                 775                 780
His Gly Phe Val Asn Pro Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu
785                 790                 795                 800
Asn Glu Pro Glu Thr Cys Met Val Glu Lys Met Asn Leu Thr Phe His
                805                 810                 815
Val Ile Asn Thr Gly Asn Ser Met Ala Pro Asn Val Ser Val Glu Ile
            820                 825                 830
Met Val Pro Asn Ser Phe Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile
        835                 840                 845
Leu Asp Val Gln Thr Thr Thr Gly Glu Cys His Phe Glu Asn Tyr Gln
    850                 855                 860
Arg Val Cys Ala Leu Glu Gln Gln Lys Ser Ala Met Gln Thr Leu Lys
865                 870                 875                 880
Gly Ile Val Arg Phe Leu Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys
                885                 890                 895
Ile Lys Ala Asp Pro His Cys Leu Phe Asn Leu Cys Asn Phe Gly Lys
            900                 905                 910
Met Glu Ser Gly Lys Glu Ala Ser Val His Ile Gln Leu Glu Gly Arg
        915                 920                 925
Pro Ser Ile Leu Glu Met Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile
    930                 935                 940
Arg Ala Thr Gly Phe Pro Glu Pro Asn Pro Arg Val Ile Glu Leu Asn
945                 950                 955                 960
Lys Asp Glu Asn Val Ala His Val Leu Leu Glu Gly Leu His His Gln
                965                 970                 975
Arg Pro Lys Arg Tyr Phe Thr Asp Pro Glu Glu Pro Lys Ser Cys Asp
            980                 985                 990
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
        995                 1000                1005
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
    1010                1015                1020
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
1025                1030                1035                1040
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                1045                1050                1055
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
            1060                1065                1070
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
        1075                1080                1085
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
    1090                1095                1100
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
1105                1110                1115                1120
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
                1125                1130                1135
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
            1140                1145                1150
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
        1155                1160                1165
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
    1170                1175                1180
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
1185                1190                1195                1200
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                1205                1210                1215
Gly Lys


<210> 694
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 694
Met Phe Pro Thr Glu Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15
Gly Pro Glu Ala Ala Val Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg
                85                  90                  95
Cys Arg Ile Gly Lys Asn Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu
            100                 105                 110
Gly Ser Pro Asn Gly Glu Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg
        115                 120                 125
Asp Asn Gln Trp Leu Gly Val Thr Leu Ser Arg Gln Pro Gly Glu Asn
    130                 135                 140
Gly Ser Ile Val Thr Cys Gly His Arg Trp Lys Asn Ile Phe Tyr Ile
145                 150                 155                 160
Lys Asn Glu Asn Lys Leu Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro
                165                 170                 175
Asp Leu Arg Thr Glu Leu Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp
            180                 185                 190
Tyr Val Lys Lys Phe Gly Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile
        195                 200                 205
Ser Ser Phe Tyr Thr Lys Asp Leu Ile Val Met Gly Ala Pro Gly Ser
    210                 215                 220
Ser Tyr Trp Thr Gly Ser Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys
225                 230                 235                 240
Tyr Lys Ala Phe Leu Asp Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr
                245                 250                 255
Leu Gly Tyr Ser Val Gly Ala Gly His Phe Arg Ser Gln His Thr Thr
            260                 265                 270
Glu Val Val Gly Gly Ala Pro Gln His Glu Gln Ile Gly Lys Ala Tyr
        275                 280                 285
Ile Phe Ser Ile Asp Glu Lys Glu Leu Asn Ile Leu His Glu Met Lys
    290                 295                 300
Gly Lys Lys Leu Gly Ser Tyr Phe Gly Ala Ser Val Cys Ala Val Asp
305                 310                 315                 320
Leu Asn Ala Asp Gly Phe Ser Asp Leu Leu Val Gly Ala Pro Met Gln
                325                 330                 335
Ser Thr Ile Arg Glu Glu Gly Arg Val Phe Val Tyr Ile Asn Ser Gly
            340                 345                 350
Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Val Gly Ser Asp
        355                 360                 365
Lys Tyr Ala Ala Arg Phe Gly Glu Ser Ile Val Asn Leu Gly Asp Ile
    370                 375                 380
Asp Asn Asp Gly Phe Glu Asp Val Ala Ile Gly Ala Pro Gln Glu Asp
385                 390                 395                 400
Asp Leu Gln Gly Ala Ile Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile
                405                 410                 415
Ser Ser Thr Phe Ser Gln Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser
            420                 425                 430
Leu Ser Met Phe Gly Gln Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn
        435                 440                 445
Asn Gly Tyr Val Asp Val Ala Val Gly Ala Phe Arg Ser Asp Ser Ala
    450                 455                 460
Val Leu Leu Arg Thr Arg Pro Val Val Ile Val Asp Ala Ser Leu Ser
465                 470                 475                 480
His Pro Glu Ser Val Asn Arg Thr Lys Phe Asp Cys Val Glu Asn Gly
                485                 490                 495
Trp Pro Ser Val Cys Ile Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly
            500                 505                 510
Lys Glu Val Pro Gly Tyr Ile Val Leu Phe Tyr Asn Met Ser Leu Asp
        515                 520                 525
Val Asn Arg Lys Ala Glu Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn
    530                 535                 540
Gly Thr Ser Asp Val Ile Thr Gly Ser Ile Gln Val Ser Ser Arg Glu
545                 550                 555                 560
Ala Asn Cys Arg Thr His Gln Ala Phe Met Arg Lys Asp Val Arg Asp
                565                 570                 575
Ile Leu Thr Pro Ile Gln Ile Glu Ala Ala Tyr His Leu Gly Pro His
            580                 585                 590
Val Ile Ser Lys Arg Ser Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile
        595                 600                 605
Leu Gln Gln Lys Lys Glu Lys Asp Ile Met Lys Lys Thr Ile Asn Phe
    610                 615                 620
Ala Arg Phe Cys Ala His Glu Asn Cys Ser Ala Asp Leu Gln Val Ser
625                 630                 635                 640
Ala Lys Ile Gly Phe Leu Lys Pro His Glu Asn Lys Thr Tyr Leu Ala
                645                 650                 655
Val Gly Ser Met Lys Thr Leu Met Leu Asn Val Ser Leu Phe Asn Ala
            660                 665                 670
Gly Asp Asp Ala Tyr Glu Thr Thr Leu His Val Lys Leu Pro Val Gly
        675                 680                 685
Leu Tyr Phe Ile Lys Ile Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys
    690                 695                 700
Glu Val Thr Asp Asn Ser Gly Val Val Gln Leu Asp Cys Ser Ile Gly
705                 710                 715                 720
Tyr Ile Tyr Val Asp His Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu
                725                 730                 735
Asp Val Ser Ser Leu Ser Arg Ala Glu Glu Asp Leu Ser Ile Thr Val
            740                 745                 750
His Ala Thr Cys Glu Asn Glu Glu Glu Met Asp Asn Leu Lys His Ser
        755                 760                 765
Arg Val Thr Val Ala Ile Pro Leu Lys Tyr Glu Val Lys Leu Thr Val
    770                 775                 780
His Gly Phe Val Asn Pro Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu
785                 790                 795                 800
Asn Glu Pro Glu Thr Cys Met Val Glu Lys Met Asn Leu Thr Phe His
                805                 810                 815
Val Ile Asn Thr Gly Asn Ser Met Ala Pro Asn Val Ser Val Glu Ile
            820                 825                 830
Met Val Pro Asn Ser Phe Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile
        835                 840                 845
Leu Asp Val Gln Thr Thr Thr Gly Glu Cys His Phe Glu Asn Tyr Gln
    850                 855                 860
Arg Val Cys Ala Leu Glu Gln Gln Lys Ser Ala Met Gln Thr Leu Lys
865                 870                 875                 880
Gly Ile Val Gln Phe Leu Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys
                885                 890                 895
Ile Lys Ala Asp Pro His Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys
            900                 905                 910
Met Glu Ser Gly Lys Glu Ala Ser Val His Ile Gln Leu Glu Gly Arg
        915                 920                 925
Pro Ser Ile Leu Glu Met Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile
    930                 935                 940
Arg Ala Thr Gly Phe Pro Glu Pro Asn Pro Arg Val Ile Glu Leu Asn
945                 950                 955                 960
Lys Asp Glu Asn Val Ala His Val Leu Leu Glu Gly Leu His His Gln
                965                 970                 975
Arg Pro Lys Arg Tyr Phe Thr Ile Val Ile Ile Ser Ser Ser Leu Leu
            980                 985                 990
Leu Gly Leu Ile Val Leu Leu Leu Ile Ser Tyr Val Met Trp Lys Ala
        995                 1000                1005
Gly Phe Phe Lys Arg Gln Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg
    1010                1015                1020
Arg Asp Ser Trp Ser Tyr Ile Asn Ser Lys Ser Asn Asp Asp
1025                1030                1035

<210> 695
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 695
Met Phe Pro Thr Glu Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15
Gly Pro Glu Ala Ala Val Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg
                85                  90                  95
Cys Arg Ile Gly Lys Asn Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu
            100                 105                 110
Gly Ser Pro Asn Gly Glu Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg
        115                 120                 125
Asp Asn Gln Trp Leu Gly Val Thr Leu Ser Arg Gln Pro Gly Glu Asn
    130                 135                 140
Gly Ser Ile Val Thr Cys Gly His Arg Trp Lys Asn Ile Phe Tyr Ile
145                 150                 155                 160
Lys Asn Glu Asn Lys Leu Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro
                165                 170                 175
Asp Leu Arg Thr Glu Leu Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp
            180                 185                 190
Tyr Val Lys Lys Phe Gly Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile
        195                 200                 205
Ser Ser Phe Tyr Thr Lys Asp Leu Ile Val Met Gly Ala Pro Gly Ser
    210                 215                 220
Ser Tyr Trp Thr Gly Ser Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys
225                 230                 235                 240
Tyr Lys Ala Phe Leu Asp Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr
                245                 250                 255
Leu Gly Tyr Ser Val Gly Ala Gly His Phe Arg Ser Gln His Thr Thr
            260                 265                 270
Glu Val Val Gly Gly Ala Pro Gln His Glu Gln Ile Gly Lys Ala Tyr
        275                 280                 285
Ile Phe Ser Ile Asp Glu Lys Glu Leu Asn Ile Leu His Glu Met Lys
    290                 295                 300
Gly Lys Lys Leu Gly Ser Tyr Phe Gly Ala Ser Val Cys Ala Val Asp
305                 310                 315                 320
Leu Asn Ala Asp Gly Phe Ser Asp Leu Leu Val Gly Ala Pro Met Gln
                325                 330                 335
Ser Thr Ile Arg Glu Glu Gly Arg Val Phe Val Tyr Ile Asn Ser Gly
            340                 345                 350
Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Val Gly Ser Asp
        355                 360                 365
Lys Tyr Ala Ala Arg Phe Gly Glu Ser Ile Val Asn Leu Gly Asp Ile
    370                 375                 380
Asp Asn Asp Gly Phe Glu Asp Val Ala Ile Gly Ala Pro Gln Glu Asp
385                 390                 395                 400
Asp Leu Gln Gly Ala Ile Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile
                405                 410                 415
Ser Ser Thr Phe Ser Gln Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser
            420                 425                 430
Leu Ser Met Phe Gly Gln Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn
        435                 440                 445
Asn Gly Tyr Val Asp Val Ala Val Gly Ala Phe Arg Ser Asp Ser Ala
    450                 455                 460
Val Leu Leu Arg Thr Arg Pro Val Val Ile Val Asp Ala Ser Leu Ser
465                 470                 475                 480
His Pro Glu Ser Val Asn Arg Thr Lys Phe Asp Cys Val Glu Asn Gly
                485                 490                 495
Trp Pro Ser Val Cys Ile Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly
            500                 505                 510
Lys Glu Val Pro Gly Tyr Ile Val Leu Phe Tyr Asn Met Ser Leu Asp
        515                 520                 525
Val Asn Arg Lys Ala Glu Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn
    530                 535                 540
Gly Thr Ser Asp Val Ile Thr Gly Ser Ile Gln Val Ser Ser Arg Glu
545                 550                 555                 560
Ala Asn Cys Arg Thr His Gln Ala Phe Met Arg Lys Asp Val Arg Asp
                565                 570                 575
Ile Leu Thr Pro Ile Gln Ile Glu Ala Ala Tyr His Leu Gly Pro His
            580                 585                 590
Val Ile Ser Lys Arg Ser Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile
        595                 600                 605
Leu Gln Gln Lys Lys Glu Lys Asp Ile Met Lys Lys Thr Ile Asn Phe
    610                 615                 620
Ala Arg Phe Cys Ala His Glu Asn Cys Ser Ala Asp Leu Gln Val Ser
625                 630                 635                 640
Ala Lys Ile Gly Phe Leu Lys Pro His Glu Asn Lys Thr Tyr Leu Ala
                645                 650                 655
Val Gly Ser Met Lys Thr Leu Met Leu Asn Val Ser Leu Phe Asn Ala
            660                 665                 670
Gly Asp Asp Ala Tyr Glu Thr Thr Leu His Val Lys Leu Pro Val Gly
        675                 680                 685
Leu Tyr Phe Ile Lys Ile Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys
    690                 695                 700
Glu Val Thr Asp Asn Ser Gly Val Val Gln Leu Asp Cys Ser Ile Gly
705                 710                 715                 720
Tyr Ile Tyr Val Asp His Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu
                725                 730                 735
Asp Val Ser Ser Leu Ser Arg Ala Glu Glu Asp Leu Ser Ile Thr Val
            740                 745                 750
His Ala Thr Cys Glu Asn Glu Glu Glu Met Asp Asn Leu Lys His Ser
        755                 760                 765
Arg Val Thr Val Ala Ile Pro Leu Lys Tyr Glu Val Lys Leu Thr Val
    770                 775                 780
His Gly Phe Val Asn Pro Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu
785                 790                 795                 800
Asn Glu Pro Glu Thr Cys Met Val Glu Lys Met Asn Leu Thr Phe His
                805                 810                 815
Val Ile Asn Thr Gly Asn Ser Met Ala Pro Asn Val Ser Val Glu Ile
            820                 825                 830
Met Val Pro Asn Ser Phe Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile
        835                 840                 845
Leu Asp Val Gln Thr Thr Thr Gly Glu Cys His Phe Glu Asn Tyr Gln
    850                 855                 860
Arg Val Cys Ala Leu Glu Gln Gln Lys Ser Ala Met Gln Thr Leu Lys
865                 870                 875                 880
Gly Ile Val Arg Phe Leu Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys
                885                 890                 895
Ile Lys Ala Asp Pro His Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys
            900                 905                 910
Met Glu Ser Gly Lys Glu Ala Ser Val His Ile Gln Leu Glu Gly Arg
        915                 920                 925
Pro Ser Ile Leu Glu Met Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile
    930                 935                 940
Arg Ala Thr Gly Phe Pro Glu Pro Asn Pro Arg Val Ile Glu Leu Asn
945                 950                 955                 960
Lys Asp Glu Asn Val Ala His Val Leu Leu Glu Gly Leu His His Gln
                965                 970                 975
Arg Pro Lys Arg Tyr Phe Thr Ile Val Ile Ile Ser Ser Ser Leu Leu
            980                 985                 990
Leu Gly Leu Ile Val Leu Leu Leu Ile Ser Tyr Val Met Trp Lys Ala
        995                 1000                1005
Gly Phe Phe Lys Arg Gln Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg
    1010                1015                1020
Arg Asp Ser Trp Ser Tyr Ile Asn Ser Lys Ser Asn Asp Asp
1025                1030                1035

<210> 696
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 696
Met Phe Pro Thr Glu Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15
Gly Pro Glu Ala Ala Val Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg
                85                  90                  95
Cys Arg Ile Gly Lys Asn Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu
            100                 105                 110
Gly Ser Pro Asn Gly Glu Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg
        115                 120                 125
Asp Asn Gln Trp Leu Gly Val Thr Leu Ser Arg Gln Pro Gly Glu Asn
    130                 135                 140
Gly Ser Ile Val Thr Cys Gly His Arg Trp Lys Asn Ile Phe Tyr Ile
145                 150                 155                 160
Lys Asn Glu Asn Lys Leu Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro
                165                 170                 175
Asp Leu Arg Thr Glu Leu Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp
            180                 185                 190
Tyr Val Lys Lys Phe Gly Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile
        195                 200                 205
Ser Ser Phe Tyr Thr Lys Asp Leu Ile Val Met Gly Ala Pro Gly Ser
    210                 215                 220
Ser Tyr Trp Thr Gly Ser Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys
225                 230                 235                 240
Tyr Lys Ala Phe Leu Asp Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr
                245                 250                 255
Leu Gly Tyr Ser Val Gly Ala Gly His Phe Arg Ser Gln His Thr Thr
            260                 265                 270
Glu Val Val Gly Gly Ala Pro Gln His Glu Gln Ile Gly Lys Ala Tyr
        275                 280                 285
Ile Phe Ser Ile Asp Glu Lys Glu Leu Asn Ile Leu His Glu Met Lys
    290                 295                 300
Gly Lys Lys Leu Gly Ser Tyr Phe Gly Ala Ser Val Cys Ala Val Asp
305                 310                 315                 320
Leu Asn Ala Asp Gly Phe Ser Asp Leu Leu Val Gly Ala Pro Met Gln
                325                 330                 335
Ser Thr Ile Arg Glu Glu Gly Arg Val Phe Val Tyr Ile Asn Ser Gly
            340                 345                 350
Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Val Gly Ser Asp
        355                 360                 365
Lys Tyr Ala Ala Arg Phe Gly Glu Ser Ile Val Asn Leu Gly Asp Ile
    370                 375                 380
Asp Asn Asp Gly Phe Glu Asp Val Ala Ile Gly Ala Pro Gln Glu Asp
385                 390                 395                 400
Asp Leu Gln Gly Ala Ile Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile
                405                 410                 415
Ser Ser Thr Phe Ser Gln Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser
            420                 425                 430
Leu Ser Met Phe Gly Gln Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn
        435                 440                 445
Asn Gly Tyr Val Asp Val Ala Val Gly Ala Phe Arg Ser Asp Ser Ala
    450                 455                 460
Val Leu Leu Arg Thr Arg Pro Val Val Ile Val Asp Ala Ser Leu Ser
465                 470                 475                 480
His Pro Glu Ser Val Asn Arg Thr Lys Phe Asp Cys Val Glu Asn Gly
                485                 490                 495
Trp Pro Ser Val Cys Ile Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly
            500                 505                 510
Lys Glu Val Pro Gly Tyr Ile Val Leu Phe Tyr Asn Met Ser Leu Asp
        515                 520                 525
Val Asn Arg Lys Ala Glu Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn
    530                 535                 540
Gly Thr Ser Asp Val Ile Thr Gly Ser Ile Gln Val Ser Ser Arg Glu
545                 550                 555                 560
Ala Asn Cys Arg Thr His Gln Ala Phe Met Arg Lys Asp Val Arg Asp
                565                 570                 575
Ile Leu Thr Pro Ile Gln Ile Glu Ala Ala Tyr His Leu Gly Pro His
            580                 585                 590
Val Ile Ser Lys Arg Ser Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile
        595                 600                 605
Leu Gln Gln Lys Lys Glu Lys Asp Ile Met Lys Lys Thr Ile Asn Phe
    610                 615                 620
Ala Arg Phe Cys Ala His Glu Asn Cys Ser Ala Asp Leu Gln Val Ser
625                 630                 635                 640
Ala Lys Ile Gly Phe Leu Lys Pro His Glu Asn Lys Thr Tyr Leu Ala
                645                 650                 655
Val Gly Ser Met Lys Thr Leu Met Leu Asn Val Ser Leu Phe Asn Ala
            660                 665                 670
Gly Asp Asp Ala Tyr Glu Thr Thr Leu His Val Lys Leu Pro Val Gly
        675                 680                 685
Leu Tyr Phe Ile Lys Ile Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys
    690                 695                 700
Glu Val Thr Asp Asn Ser Gly Val Val Gln Leu Asp Cys Ser Ile Gly
705                 710                 715                 720
Tyr Ile Tyr Val Asp His Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu
                725                 730                 735
Asp Val Ser Ser Leu Ser Arg Ala Glu Glu Asp Leu Ser Ile Thr Val
            740                 745                 750
His Ala Thr Cys Glu Asn Glu Glu Glu Met Asp Asn Leu Lys His Ser
        755                 760                 765
Arg Val Thr Val Ala Ile Pro Leu Lys Tyr Glu Val Lys Leu Thr Val
    770                 775                 780
His Gly Phe Val Asn Pro Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu
785                 790                 795                 800
Asn Glu Pro Glu Thr Cys Met Val Glu Lys Met Asn Leu Thr Phe His
                805                 810                 815
Val Ile Asn Thr Gly Asn Ser Met Ala Pro Asn Val Ser Val Glu Ile
            820                 825                 830
Met Val Pro Asn Ser Phe Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile
        835                 840                 845
Leu Asp Val Gln Thr Thr Thr Gly Glu Cys His Phe Glu Asn Tyr Gln
    850                 855                 860
Arg Val Cys Ala Leu Glu Gln Gln Lys Ser Ala Met Gln Thr Leu Lys
865                 870                 875                 880
Gly Ile Val Arg Phe Leu Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys
                885                 890                 895
Ile Lys Ala Asp Pro His Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys
            900                 905                 910
Met Glu Ser Gly Lys Glu Ala Ser Val His Ile Gln Leu Glu Gly Arg
        915                 920                 925
Pro Ser Ile Leu Glu Met Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile
    930                 935                 940
Arg Ala Thr Gly Phe Pro Glu Pro Asn Pro Arg Val Ile Glu Leu Asn
945                 950                 955                 960
Lys Asp Glu Asn Val Ala His Val Leu Leu Glu Gly Leu His His Gln
                965                 970                 975
Arg Pro Lys Arg Tyr Phe Thr Ile Val Ile Ile Ser Ser Ser Leu Leu
            980                 985                 990
Leu Gly Leu Ile Val Leu Leu Leu Ile Ser Tyr Val Met Trp Lys Ala
        995                 1000                1005
Gly Phe Phe Lys Arg Gln Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg
    1010                1015                1020
Arg Asp Ser Trp Ser Tyr Ile Asn Ser Lys Ser Asn Asp Asp
1025                1030                1035

<210> 697
<211> 3494
<212> PRT
<213> Homo sapiens

<400> 697
Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly
 1               5                  10                  15
Asn Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro Gln
            20                  25                  30
Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile Tyr
        35                  40                  45
Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn Thr
    50                  55                  60
Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro Gln
65                  70                  75                  80
Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg Cys
                85                  90                  95
Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu Pro
            100                 105                 110
Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Ser Ser Pro Asn Ser
        115                 120                 125
Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly Pro
    130                 135                 140
Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr Cys
145                 150                 155                 160
Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu Asp
                165                 170                 175
Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro Pro
            180                 185                 190
Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys Pro
        195                 200                 205
Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile Cys
    210                 215                 220
Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser Thr
225                 230                 235                 240
Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly Asn
                245                 250                 255
Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu Ser
            260                 265                 270
His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr Phe
        275                 280                 285
Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn Ile
    290                 295                 300
Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val Asp
305                 310                 315                 320
Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly Ala
                325                 330                 335
Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly Ile
            340                 345                 350
Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His Asp
        355                 360                 365
Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu Arg
    370                 375                 380
Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro His
385                 390                 395                 400
Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln Leu
                405                 410                 415
Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser Asp
            420                 425                 430
Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly Arg
        435                 440                 445
Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly Ile
    450                 455                 460
Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly Asn
465                 470                 475                 480
Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro Asp
                485                 490                 495
Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His Asp
            500                 505                 510
Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr Gln
        515                 520                 525
Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro Leu
    530                 535                 540
Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser Gln
545                 550                 555                 560
Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser Asp
                565                 570                 575
Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe Leu
            580                 585                 590
Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr Met
        595                 600                 605
Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His Val
    610                 615                 620
Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val Arg
625                 630                 635                 640
Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile Ser
                645                 650                 655
His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile Asp
            660                 665                 670
Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala Cys
        675                 680                 685
Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe Pro
    690                 695                 700
Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln Pro
705                 710                 715                 720
Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly Ser
                725                 730                 735
Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser Ile
            740                 745                 750
Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro Ser
        755                 760                 765
Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys Ser
    770                 775                 780
Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu Asp
785                 790                 795                 800
Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln Ser
                805                 810                 815
Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp His
            820                 825                 830
Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr Phe
        835                 840                 845
His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val Tyr
    850                 855                 860
Asp Thr Asp Ser Glu Thr Ser Leu Gly Arg Tyr Cys Gly Lys Ser Ile
865                 870                 875                 880
Pro Pro Ser Leu Thr Ser Ser Gly Asn Ser Leu Met Leu Val Phe Val
                885                 890                 895
Thr Asp Ser Asp Leu Ala Tyr Glu Gly Phe Leu Ile Asn Tyr Glu Ala
            900                 905                 910
Ile Ser Ala Ala Thr Ala Cys Leu Gln Asp Tyr Thr Asp Asp Leu Gly
        915                 920                 925
Thr Phe Thr Ser Pro Asn Phe Pro Asn Asn Tyr Pro Asn Asn Trp Glu
    930                 935                 940
Cys Ile Tyr Arg Ile Thr Val Arg Thr Gly Gln Leu Ile Ala Val His
945                 950                 955                 960
Phe Thr Asn Phe Ser Leu Glu Glu Ala Ile Gly Asn Tyr Tyr Thr Asp
                965                 970                 975
Phe Leu Glu Ile Arg Asp Gly Gly Tyr Glu Lys Ser Pro Leu Leu Gly
            980                 985                 990
Ile Phe Tyr Gly Ser Asn Leu Pro Pro Thr Ile Ile Ser His Ser Asn
        995                 1000                1005
Lys Leu Trp Leu Lys Phe Lys Ser Asp Gln Ile Asp Thr Arg Ser Gly
    1010                1015                1020
Phe Ser Ala Tyr Trp Asp Gly Ser Ser Thr Gly Cys Gly Gly Asn Leu
1025                1030                1035                1040
Thr Thr Ser Ser Gly Thr Phe Ile Ser Pro Asn Tyr Pro Met Pro Tyr
                1045                1050                1055
Tyr His Ser Ser Glu Cys Tyr Trp Trp Leu Lys Ser Ser His Gly Ser
            1060                1065                1070
Ala Phe Glu Leu Glu Phe Lys Asp Phe His Leu Glu His His Pro Asn
        1075                1080                1085
Cys Thr Leu Asp Tyr Leu Ala Val Tyr Asp Gly Pro Ser Ser Asn Ser
    1090                1095                1100
His Leu Leu Thr Gln Leu Cys Gly Asp Glu Lys Pro Pro Leu Ile Arg
1105                1110                1115                1120
Ser Ser Gly Asp Ser Met Phe Ile Lys Leu Arg Thr Asp Glu Gly Gln
                1125                1130                1135
Gln Gly Arg Gly Phe Lys Ala Glu Tyr Arg Gln Thr Cys Glu Asn Val
            1140                1145                1150
Val Ile Val Asn Gln Thr Tyr Gly Ile Leu Glu Ser Ile Gly Tyr Pro
        1155                1160                1165
Asn Pro Tyr Ser Glu Asn Gln His Cys Asn Trp Thr Ile Arg Ala Thr
    1170                1175                1180
Thr Gly Asn Thr Val Asn Tyr Thr Phe Leu Ala Phe Asp Leu Glu His
1185                1190                1195                1200
His Ile Asn Cys Ser Thr Asp Tyr Leu Glu Leu Tyr Asp Gly Pro Arg
                1205                1210                1215
Gln Met Gly Arg Tyr Cys Gly Val Asp Leu Pro Pro Pro Gly Ser Thr
            1220                1225                1230
Thr Ser Ser Lys Leu Gln Val Leu Leu Leu Thr Asp Gly Val Gly Arg
        1235                1240                1245
Arg Glu Lys Gly Phe Gln Met Gln Trp Phe Val Tyr Gly Cys Gly Gly
    1250                1255                1260
Glu Leu Ser Gly Ala Thr Gly Ser Phe Ser Ser Pro Gly Phe Pro Asn
1265                1270                1275                1280
Arg Tyr Pro Pro Asn Lys Glu Cys Ile Trp Tyr Ile Arg Thr Asp Pro
                1285                1290                1295
Gly Ser Ser Ile Gln Leu Thr Ile His Asp Phe Asp Val Glu Tyr His
            1300                1305                1310
Ser Arg Cys Asn Phe Asp Val Leu Glu Ile Tyr Gly Gly Pro Asp Phe
        1315                1320                1325
His Ser Pro Arg Ile Ala Gln Leu Cys Thr Gln Arg Ser Pro Glu Asn
    1330                1335                1340
Pro Met Gln Val Ser Ser Thr Gly Asn Glu Leu Ala Ile Arg Phe Lys
1345                1350                1355                1360
Thr Asp Leu Ser Ile Asn Gly Arg Gly Phe Asn Ala Ser Trp Gln Ala
                1365                1370                1375
Val Thr Gly Gly Cys Gly Gly Ile Phe Gln Ala Pro Ser Gly Glu Ile
            1380                1385                1390
His Ser Pro Asn Tyr Pro Ser Pro Tyr Arg Ser Asn Thr Asp Cys Ser
        1395                1400                1405
Trp Val Ile Arg Val Asp Arg Tyr His Arg Val Leu Leu Asn Phe Thr
    1410                1415                1420
Asp Phe Asp Leu Glu Pro Gln Asp Ser Cys Ile Met Ala Tyr Asp Gly
1425                1430                1435                1440
Leu Ser Ser Thr Met Ser Arg Leu Ala Arg Thr Cys Gly Arg Glu Gln
                1445                1450                1455
Leu Ala Asn Pro Ile Val Ser Ser Gly Asn Ser Leu Phe Leu Arg Phe
            1460                1465                1470
Gln Ser Gly Pro Ser Arg Gln Asn Arg Gly Phe Arg Ala Gln Phe Arg
        1475                1480                1485
Gln Ala Cys Gly Gly His Ile Leu Thr Ser Ser Phe Asp Thr Val Ser
    1490                1495                1500
Ser Pro Arg Phe Pro Ala Asn Tyr Pro Asn Asn Gln Asn Cys Ser Trp
1505                1510                1515                1520
Ile Ile Gln Ala Gln Pro Pro Leu Asn His Ile Thr Leu Ser Phe Thr
                1525                1530                1535
His Phe Glu Leu Glu Arg Ser Thr Thr Cys Ala Arg Asp Phe Val Glu
            1540                1545                1550
Ile Leu Asp Gly Gly His Glu Asp Ala Pro Leu Arg Gly Arg Tyr Cys
        1555                1560                1565
Gly Thr Asp Met Pro His Pro Ile Thr Ser Phe Ser Ser Ala Leu Thr
    1570                1575                1580
Leu Arg Phe Val Ser Asp Ser Ser Ile Ser Ala Gly Gly Phe His Thr
1585                1590                1595                1600
Thr Val Thr Ala Ser Val Ser Ala Cys Gly Gly Thr Phe Tyr Met Ala
                1605                1610                1615
Glu Gly Ile Phe Asn Ser Pro Gly Tyr Pro Asp Ile Tyr Pro Pro Asn
            1620                1625                1630
Val Glu Cys Val Trp Asn Ile Ile Ser Ser Pro Gly Asn Arg Leu Gln
        1635                1640                1645
Leu Ser Phe Ile Ser Phe Gln Leu Glu Asp Ser Gln Asp Cys Ser Arg
    1650                1655                1660
Asp Phe Val Glu Ile Arg Glu Gly Asn Ala Thr Gly His Leu Val Gly
1665                1670                1675                1680
Arg Tyr Cys Gly Asn Ser Phe Pro Leu Asn Tyr Ser Ser Ile Val Gly
                1685                1690                1695
His Thr Leu Trp Val Arg Phe Ile Ser Asp Gly Ser Gly Ser Gly Thr
            1700                1705                1710
Gly Phe Gln Ala Thr Phe Met Lys Ile Phe Gly Asn Asp Asn Ile Val
        1715                1720                1725
Gly Thr His Gly Lys Val Ala Ser Pro Phe Trp Pro Glu Asn Tyr Pro
    1730                1735                1740
His Asn Ser Asn Tyr Gln Trp Thr Val Asn Val Asn Ala Ser His Val
1745                1750                1755                1760
Val His Gly Arg Ile Leu Glu Met Asp Ile Glu Glu Ile Gln Asn Cys
                1765                1770                1775
Tyr Tyr Asp Lys Leu Arg Ile Tyr Asp Gly Pro Ser Ile His Ala Arg
            1780                1785                1790
Leu Ile Gly Ala Tyr Cys Gly Thr Gln Thr Glu Ser Phe Ser Ser Thr
        1795                1800                1805
Gly Asn Ser Leu Thr Phe His Phe Tyr Ser Asp Ser Ser Ile Ser Gly
    1810                1815                1820
Lys Gly Phe Leu Leu Glu Trp Phe Ala Val Asp Ala Pro Asp Gly Val
1825                1830                1835                1840
Leu Pro Thr Ile Ala Pro Gly Ala Cys Gly Gly Phe Leu Arg Thr Gly
                1845                1850                1855
Asp Ala Pro Val Phe Leu Phe Ser Pro Gly Trp Pro Asp Ser Tyr Ser
            1860                1865                1870
Asn Arg Val Asp Cys Thr Trp Leu Ile Gln Ala Pro Asp Ser Thr Val
        1875                1880                1885
Glu Leu Asn Ile Leu Ser Leu Asp Ile Glu Ser His Arg Thr Cys Ala
    1890                1895                1900
Tyr Asp Ser Leu Val Ile Arg Asp Gly Asp Asn Asn Leu Ala Gln Gln
1905                1910                1915                1920
Leu Ala Val Leu Cys Gly Arg Glu Ile Pro Gly Pro Ile Arg Ser Thr
                1925                1930                1935
Gly Glu Tyr Met Phe Ile Arg Phe Thr Ser Asp Ser Ser Val Thr Arg
            1940                1945                1950
Ala Gly Phe Asn Ala Ser Phe His Lys Ser Cys Gly Gly Tyr Leu His
        1955                1960                1965
Ala Asp Arg Gly Ile Ile Thr Ser Pro Lys Tyr Pro Glu Thr Tyr Pro
    1970                1975                1980
Ser Asn Leu Asn Cys Ser Trp His Val Leu Val Gln Ser Gly Leu Thr
1985                1990                1995                2000
Ile Ala Val His Phe Glu Gln Pro Phe Gln Ile Pro Asn Gly Asp Ser
                2005                2010                2015
Ser Cys Asn Gln Gly Asp Tyr Leu Val Leu Arg Asn Gly Pro Asp Ile
            2020                2025                2030
Tyr Ser Pro Pro Leu Gly Pro Pro Gly Gly Asn Gly His Phe Cys Gly
        2035                2040                2045
Ser His Ala Ser Ser Thr Leu Phe Thr Ser Asp Asn Gln Met Phe Val
    2050                2055                2060
Gln Phe Ile Ser Asp His Ser Asn Glu Gly Gln Gly Phe Lys Ile Lys
2065                2070                2075                2080
Tyr Glu Ala Lys Ser Leu Ala Cys Gly Gly Asn Val Tyr Ile His Asp
                2085                2090                2095
Ala Asp Ser Ala Gly Tyr Val Thr Ser Pro Asn His Pro His Asn Tyr
            2100                2105                2110
Pro Pro His Ala Asp Cys Ile Trp Ile Leu Ala Ala Pro Pro Glu Thr
        2115                2120                2125
Arg Ile Gln Leu Gln Phe Glu Asp Arg Phe Asp Ile Glu Val Thr Pro
    2130                2135                2140
Asn Cys Thr Ser Asn Tyr Leu Glu Leu Arg Asp Gly Val Asp Ser Asp
2145                2150                2155                2160
Ala Pro Ile Leu Ser Lys Phe Cys Gly Thr Ser Leu Pro Ser Ser Gln
                2165                2170                2175
Trp Ser Ser Gly Glu Val Met Tyr Leu Arg Phe Arg Ser Asp Asn Ser
            2180                2185                2190
Pro Thr His Val Gly Phe Lys Ala Lys Tyr Ser Ile Ala Gln Cys Gly
        2195                2200                2205
Gly Arg Val Pro Gly Gln Ser Gly Val Val Glu Ser Ile Gly His Pro
    2210                2215                2220
Thr Leu Pro Tyr Arg Asp Asn Leu Phe Cys Glu Trp His Leu Gln Gly
2225                2230                2235                2240
Leu Ser Gly His Tyr Leu Thr Ile Ser Phe Glu Asp Phe Asn Leu Gln
                2245                2250                2255
Asn Ser Ser Gly Cys Glu Lys Asp Phe Val Glu Ile Trp Asp Asn His
            2260                2265                2270
Thr Ser Gly Asn Ile Leu Gly Arg Tyr Cys Gly Asn Thr Ile Pro Asp
        2275                2280                2285
Ser Ile Asp Thr Ser Ser Asn Thr Ala Val Val Arg Phe Val Thr Asp
    2290                2295                2300
Gly Ser Val Thr Ala Ser Gly Phe Arg Leu Arg Phe Glu Ser Ser Met
2305                2310                2315                2320
Glu Glu Cys Gly Gly Asp Leu Gln Gly Ser Ile Gly Thr Phe Thr Ser
                2325                2330                2335
Pro Asn Tyr Pro Asn Pro Asn Pro His Gly Arg Ile Cys Glu Trp Arg
            2340                2345                2350
Ile Thr Ala Pro Glu Gly Arg Arg Ile Thr Leu Met Phe Asn Asn Leu
        2355                2360                2365
Arg Leu Ala Thr His Pro Ser Cys Asn Asn Glu His Val Ile Val Phe
    2370                2375                2380
Asn Gly Ile Arg Ser Asn Ser Pro Gln Leu Glu Lys Leu Cys Ser Ser
2385                2390                2395                2400
Val Asn Val Ser Asn Glu Ile Lys Ser Ser Gly Asn Thr Met Lys Val
                2405                2410                2415
Ile Phe Phe Thr Asp Gly Ser Arg Pro Tyr Gly Gly Phe Thr Ala Ser
            2420                2425                2430
Tyr Thr Ser Ser Glu Asp Ala Val Cys Gly Gly Ser Leu Pro Asn Thr
        2435                2440                2445
Pro Glu Gly Asn Phe Thr Ser Pro Gly Tyr Asp Gly Val Arg Asn Tyr
    2450                2455                2460
Ser Arg Asn Leu Asn Cys Glu Trp Thr Leu Ser Asn Pro Asn Gln Gly
2465                2470                2475                2480
Asn Ser Ser Ile Ser Ile His Phe Glu Asp Phe Tyr Leu Glu Ser His
                2485                2490                2495
Gln Asp Cys Gln Phe Asp Val Leu Glu Phe Arg Val Gly Asp Ala Asp
            2500                2505                2510
Gly Pro Leu Met Trp Arg Leu Cys Gly Pro Ser Lys Pro Thr Leu Pro
        2515                2520                2525
Leu Val Ile Pro Tyr Ser Gln Val Trp Ile His Phe Val Thr Asn Glu
    2530                2535                2540
Arg Val Glu His Ile Gly Phe His Ala Lys Tyr Ser Phe Thr Asp Cys
2545                2550                2555                2560
Gly Gly Ile Gln Ile Gly Asp Ser Gly Val Ile Thr Ser Pro Asn Tyr
                2565                2570                2575
Pro Asn Ala Tyr Asp Ser Leu Thr His Cys Ser Trp Leu Leu Glu Ala
            2580                2585                2590
Pro Gln Gly His Thr Ile Thr Leu Thr Phe Ser Asp Phe Asp Ile Glu
        2595                2600                2605
Pro His Thr Thr Cys Ala Trp Asp Ser Val Thr Val Arg Asn Gly Gly
    2610                2615                2620
Ser Pro Glu Ser Pro Ile Ile Gly Gln Tyr Cys Gly Asn Ser Asn Pro
2625                2630                2635                2640
Arg Thr Ile Gln Ser Gly Ser Asn Gln Leu Val Val Thr Phe Asn Ser
                2645                2650                2655
Asp His Ser Leu Gln Gly Gly Gly Phe Tyr Ala Thr Trp Asn Thr Gln
            2660                2665                2670
Thr Leu Gly Cys Gly Gly Ile Phe His Ser Asp Asn Gly Thr Ile Arg
        2675                2680                2685
Ser Pro His Trp Pro Gln Asn Phe Pro Glu Asn Ser Arg Cys Ser Trp
    2690                2695                2700
Thr Ala Ile Thr His Lys Ser Lys His Leu Glu Ile Ser Phe Asp Asn
2705                2710                2715                2720
Asn Phe Leu Ile Pro Ser Gly Asp Gly Gln Cys Gln Asn Ser Phe Val
                2725                2730                2735
Lys Val Trp Ala Gly Thr Glu Glu Val Asp Lys Ala Leu Leu Ala Thr
            2740                2745                2750
Gly Cys Gly Asn Val Ala Pro Gly Pro Val Ile Thr Pro Ser Asn Thr
        2755                2760                2765
Phe Thr Ala Val Phe Gln Ser Gln Glu Ala Pro Ala Gln Gly Phe Ser
    2770                2775                2780
Ala Ser Phe Val Ser Arg Cys Gly Ser Asn Phe Thr Gly Pro Ser Gly
2785                2790                2795                2800
Tyr Ile Ile Ser Pro Asn Tyr Pro Lys Gln Tyr Asp Asn Asn Met Asn
                2805                2810                2815
Cys Thr Tyr Val Ile Glu Ala Asn Pro Leu Ser Val Val Leu Leu Thr
            2820                2825                2830
Phe Val Ser Phe His Leu Glu Ala Arg Ser Ala Val Thr Gly Ser Cys
        2835                2840                2845
Val Asn Asp Gly Val His Ile Ile Arg Gly Tyr Ser Val Met Ser Thr
    2850                2855                2860
Pro Phe Ala Thr Val Cys Gly Asp Glu Met Pro Ala Pro Leu Thr Ile
2865                2870                2875                2880
Ala Gly Pro Val Leu Leu Asn Phe Tyr Ser Asn Glu Gln Ile Thr Asp
                2885                2890                2895
Phe Gly Phe Lys Phe Ser Tyr Arg Ile Ile Ser Cys Gly Gly Val Phe
            2900                2905                2910
Asn Phe Ser Ser Gly Ile Ile Thr Ser Pro Ala Tyr Ser Tyr Ala Asp
        2915                2920                2925
Tyr Pro Asn Asp Met His Cys Leu Tyr Thr Ile Thr Val Ser Asp Asp
    2930                2935                2940
Lys Val Ile Glu Leu Lys Phe Ser Asp Phe Asp Val Val Pro Ser Thr
2945                2950                2955                2960
Ser Cys Ser His Asp Tyr Leu Ala Ile Tyr Asp Gly Ala Asn Thr Ser
                2965                2970                2975
Asp Pro Leu Leu Gly Lys Phe Cys Gly Ser Lys Arg Pro Pro Asn Val
            2980                2985                2990
Lys Ser Ser Asn Asn Ser Met Leu Leu Val Phe Lys Thr Asp Ser Phe
        2995                3000                3005
Gln Thr Ala Lys Gly Trp Lys Met Ser Phe Arg Gln Thr Leu Gly Pro
    3010                3015                3020
Gln Gln Gly Cys Gly Gly Tyr Leu Thr Gly Ser Asn Asn Thr Phe Ala
3025                3030                3035                3040
Ser Pro Asp Ser Asp Ser Asn Gly Met Tyr Asp Lys Asn Leu Asn Cys
                3045                3050                3055
Val Trp Ile Ile Ile Ala Pro Val Asn Lys Val Ile His Leu Thr Phe
            3060                3065                3070
Asn Thr Phe Ala Leu Glu Ala Ala Ser Thr Arg Gln Arg Cys Leu Tyr
        3075                3080                3085
Asp Tyr Val Lys Leu Tyr Asp Gly Asp Ser Glu Asn Ala Asn Leu Ala
    3090                3095                3100
Gly Thr Phe Cys Gly Ser Thr Val Pro Ala Pro Phe Ile Ser Ser Gly
3105                3110                3115                3120
Asn Phe Leu Thr Val Gln Phe Ile Ser Asp Leu Thr Leu Glu Arg Glu
                3125                3130                3135
Gly Phe Asn Ala Thr Tyr Thr Ile Met Asp Met Pro Cys Gly Gly Thr
            3140                3145                3150
Tyr Asn Ala Thr Trp Thr Pro Gln Asn Ile Ser Ser Pro Asn Ser Ser
        3155                3160                3165
Asp Pro Asp Val Pro Phe Ser Ile Cys Thr Trp Val Ile Asp Ser Pro
    3170                3175                3180
Pro His Gln Gln Val Lys Ile Thr Val Trp Ala Leu Gln Leu Thr Ser
3185                3190                3195                3200
Gln Asp Cys Thr Gln Asn Tyr Leu Gln Leu Gln Asp Ser Pro Gln Gly
                3205                3210                3215
His Gly Asn Ser Arg Phe Gln Phe Cys Gly Arg Asn Ala Ser Ala Val
            3220                3225                3230
Pro Val Phe Tyr Ser Ser Met Ser Thr Ala Met Val Ile Phe Lys Ser
        3235                3240                3245
Gly Val Val Asn Arg Asn Ser Arg Met Ser Phe Thr Tyr Gln Ile Ala
    3250                3255                3260
Asp Cys Asn Arg Asp Tyr His Lys Ala Phe Gly Asn Leu Arg Ser Pro
3265                3270                3275                3280
Gly Trp Pro Asp Asn Tyr Asp Asn Asp Lys Asp Cys Thr Val Thr Leu
                3285                3290                3295
Thr Ala Pro Gln Asn His Thr Ile Ser Leu Phe Phe His Ser Leu Gly
            3300                3305                3310
Ile Glu Asn Ser Val Glu Cys Arg Asn Asp Phe Leu Glu Val Arg Asn
        3315                3320                3325
Gly Ser Asn Ser Asn Ser Pro Leu Leu Gly Lys Tyr Cys Gly Thr Leu
    3330                3335                3340
Leu Pro Asn Pro Val Phe Ser Gln Asn Asn Glu Leu Tyr Leu Arg Phe
3345                3350                3355                3360
Lys Ser Asp Ser Val Thr Ser Asp Arg Gly Tyr Glu Ile Ile Trp Thr
                3365                3370                3375
Ser Ser Pro Ser Gly Cys Gly Gly Thr Leu Tyr Gly Asp Arg Gly Ser
            3380                3385                3390
Phe Thr Ser Pro Gly Tyr Pro Gly Thr Tyr Pro Asn Asn Thr Tyr Cys
        3395                3400                3405
Glu Trp Val Leu Val Ala Pro Ala Gly Arg Leu Val Thr Ile Asn Phe
    3410                3415                3420
Tyr Phe Ile Ser Ile Asp Asp Pro Gly Asp Cys Val Gln Asn Tyr Leu
3425                3430                3435                3440
Thr Leu Tyr Asp Gly Pro Asn Ala Ser Ser Pro Ser Ser Gly Pro Tyr
                3445                3450                3455
Cys Gly Gly Asp Thr Ser Ile Ala Pro Phe Val Ala Ser Ser Asn Gln
            3460                3465                3470
Val Phe Ile Lys Phe His Ala Asp Tyr Ala Arg Arg Pro Ser Ala Phe
        3475                3480                3485
Arg Leu Thr Trp Asp Ser
    3490

<210> 698
<211> 3623
<212> PRT
<213> Homo sapiens

<400> 698
Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu
 1               5                  10                  15
Ile Phe Ala Glu Val Asn Gly Glu Arg Gly Glu Leu Glu Leu Gln Arg
            20                  25                  30
Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg
        35                  40                  45
Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg
    50                  55                  60
Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu
65                  70                  75                  80
Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys
                85                  90                  95
Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln
            100                 105                 110
Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln
        115                 120                 125
Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly
    130                 135                 140
Gly Asn Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro
145                 150                 155                 160
Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile
                165                 170                 175
Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn
            180                 185                 190
Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro
        195                 200                 205
Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg
    210                 215                 220
Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu
225                 230                 235                 240
Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Ser Ser Pro Asn
                245                 250                 255
Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly
            260                 265                 270
Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr
        275                 280                 285
Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu
    290                 295                 300
Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro
305                 310                 315                 320
Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys
                325                 330                 335
Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile
            340                 345                 350
Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser
        355                 360                 365
Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly
    370                 375                 380
Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu
385                 390                 395                 400
Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr
                405                 410                 415
Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn
            420                 425                 430
Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val
        435                 440                 445
Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly
    450                 455                 460
Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly
465                 470                 475                 480
Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His
                485                 490                 495
Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu
            500                 505                 510
Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro
        515                 520                 525
His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln
    530                 535                 540
Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser
545                 550                 555                 560
Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly
                565                 570                 575
Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly
            580                 585                 590
Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly
        595                 600                 605
Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro
    610                 615                 620
Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His
625                 630                 635                 640
Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr
                645                 650                 655
Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro
            660                 665                 670
Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser
        675                 680                 685
Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser
    690                 695                 700
Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe
705                 710                 715                 720
Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr
                725                 730                 735
Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His
            740                 745                 750
Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val
        755                 760                 765
Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile
    770                 775                 780
Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile
785                 790                 795                 800
Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala
                805                 810                 815
Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe
            820                 825                 830
Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln
        835                 840                 845
Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly
    850                 855                 860
Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser
865                 870                 875                 880
Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro
                885                 890                 895
Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys
            900                 905                 910
Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu
        915                 920                 925
Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln
    930                 935                 940
Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp
945                 950                 955                 960
His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr
                965                 970                 975
Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val
            980                 985                 990
Tyr Asp Thr Asp Ser Glu Thr Ser Leu Gly Arg Tyr Cys Gly Lys Ser
        995                 1000                1005
Ile Pro Pro Ser Leu Thr Ser Ser Gly Asn Ser Leu Met Leu Val Phe
    1010                1015                1020
Val Thr Asp Ser Asp Leu Ala Tyr Glu Gly Phe Leu Ile Asn Tyr Glu
1025                1030                1035                1040
Ala Ile Ser Ala Ala Thr Ala Cys Leu Gln Asp Tyr Thr Asp Asp Leu
                1045                1050                1055
Gly Thr Phe Thr Ser Pro Asn Phe Pro Asn Asn Tyr Pro Asn Asn Trp
            1060                1065                1070
Glu Cys Ile Tyr Arg Ile Thr Val Arg Thr Gly Gln Leu Ile Ala Val
        1075                1080                1085
His Phe Thr Asn Phe Ser Leu Glu Glu Ala Ile Gly Asn Tyr Tyr Thr
    1090                1095                1100
Asp Phe Leu Glu Ile Arg Asp Gly Gly Tyr Glu Lys Ser Pro Leu Leu
1105                1110                1115                1120
Gly Ile Phe Tyr Gly Ser Asn Leu Pro Pro Thr Ile Ile Ser His Ser
                1125                1130                1135
Asn Lys Leu Trp Leu Lys Phe Lys Ser Asp Gln Ile Asp Thr Arg Ser
            1140                1145                1150
Gly Phe Ser Ala Tyr Trp Asp Gly Ser Ser Thr Gly Cys Gly Gly Asn
        1155                1160                1165
Leu Thr Thr Ser Ser Gly Thr Phe Ile Ser Pro Asn Tyr Pro Met Pro
    1170                1175                1180
Tyr Tyr His Ser Ser Glu Cys Tyr Trp Trp Leu Lys Ser Ser His Gly
1185                1190                1195                1200
Ser Ala Phe Glu Leu Glu Phe Lys Asp Phe His Leu Glu His His Pro
                1205                1210                1215
Asn Cys Thr Leu Asp Tyr Leu Ala Val Tyr Asp Gly Pro Ser Ser Asn
            1220                1225                1230
Ser His Leu Leu Thr Gln Leu Cys Gly Asp Glu Lys Pro Pro Leu Ile
        1235                1240                1245
Arg Ser Ser Gly Asp Ser Met Phe Ile Lys Leu Arg Thr Asp Glu Gly
    1250                1255                1260
Gln Gln Gly Arg Gly Phe Lys Ala Glu Tyr Arg Gln Thr Cys Glu Asn
1265                1270                1275                1280
Val Val Ile Val Asn Gln Thr Tyr Gly Ile Leu Glu Ser Ile Gly Tyr
                1285                1290                1295
Pro Asn Pro Tyr Ser Glu Asn Gln His Cys Asn Trp Thr Ile Arg Ala
            1300                1305                1310
Thr Thr Gly Asn Thr Val Asn Tyr Thr Phe Leu Ala Phe Asp Leu Glu
        1315                1320                1325
His His Ile Asn Cys Ser Thr Asp Tyr Leu Glu Leu Tyr Asp Gly Pro
    1330                1335                1340
Arg Gln Met Gly Arg Tyr Cys Gly Val Asp Leu Pro Pro Pro Gly Ser
1345                1350                1355                1360
Thr Thr Ser Ser Lys Leu Gln Val Leu Leu Leu Thr Asp Gly Val Gly
                1365                1370                1375
Arg Arg Glu Lys Gly Phe Gln Met Gln Trp Phe Val Tyr Gly Cys Gly
            1380                1385                1390
Gly Glu Leu Ser Gly Ala Thr Gly Ser Phe Ser Ser Pro Gly Phe Pro
        1395                1400                1405
Asn Arg Tyr Pro Pro Asn Lys Glu Cys Ile Trp Tyr Ile Arg Thr Asp
    1410                1415                1420
Pro Gly Ser Ser Ile Gln Leu Thr Ile His Asp Phe Asp Val Glu Tyr
1425                1430                1435                1440
His Ser Arg Cys Asn Phe Asp Val Leu Glu Ile Tyr Gly Gly Pro Asp
                1445                1450                1455
Phe His Ser Pro Arg Ile Ala Gln Leu Cys Thr Gln Arg Ser Pro Glu
            1460                1465                1470
Asn Pro Met Gln Val Ser Ser Thr Gly Asn Glu Leu Ala Ile Arg Phe
        1475                1480                1485
Lys Thr Asp Leu Ser Ile Asn Gly Arg Gly Phe Asn Ala Ser Trp Gln
    1490                1495                1500
Ala Val Thr Gly Gly Cys Gly Gly Ile Phe Gln Ala Pro Ser Gly Glu
1505                1510                1515                1520
Ile His Ser Pro Asn Tyr Pro Ser Pro Tyr Arg Ser Asn Thr Asp Cys
                1525                1530                1535
Ser Trp Val Ile Arg Val Asp Arg Tyr His Arg Val Leu Leu Asn Phe
            1540                1545                1550
Thr Asp Phe Asp Leu Glu Pro Gln Asp Ser Cys Ile Met Ala Tyr Asp
        1555                1560                1565
Gly Leu Ser Ser Thr Met Ser Arg Leu Ala Arg Thr Cys Gly Arg Glu
    1570                1575                1580
Gln Leu Ala Asn Pro Ile Val Ser Ser Gly Asn Ser Leu Phe Leu Arg
1585                1590                1595                1600
Phe Gln Ser Gly Pro Ser Arg Gln Asn Arg Gly Phe Arg Ala Gln Phe
                1605                1610                1615
Arg Gln Ala Cys Gly Gly His Ile Leu Thr Ser Ser Phe Asp Thr Val
            1620                1625                1630
Ser Ser Pro Arg Phe Pro Ala Asn Tyr Pro Asn Asn Gln Asn Cys Ser
        1635                1640                1645
Trp Ile Ile Gln Ala Gln Pro Pro Leu Asn His Ile Thr Leu Ser Phe
    1650                1655                1660
Thr His Phe Glu Leu Glu Arg Ser Thr Thr Cys Ala Arg Asp Phe Val
1665                1670                1675                1680
Glu Ile Leu Asp Gly Gly His Glu Asp Ala Pro Leu Arg Gly Arg Tyr
                1685                1690                1695
Cys Gly Thr Asp Met Pro His Pro Ile Thr Ser Phe Ser Ser Ala Leu
            1700                1705                1710
Thr Leu Arg Phe Val Ser Asp Ser Ser Ile Ser Ala Gly Gly Phe His
        1715                1720                1725
Thr Thr Val Thr Ala Ser Val Ser Ala Cys Gly Gly Thr Phe Tyr Met
    1730                1735                1740
Ala Glu Gly Ile Phe Asn Ser Pro Gly Tyr Pro Asp Ile Tyr Pro Pro
1745                1750                1755                1760
Asn Val Glu Cys Val Trp Asn Ile Ile Ser Ser Pro Gly Asn Arg Leu
                1765                1770                1775
Gln Leu Ser Phe Ile Ser Phe Gln Leu Glu Asp Ser Gln Asp Cys Ser
            1780                1785                1790
Arg Asp Phe Val Glu Ile Arg Glu Gly Asn Ala Thr Gly His Leu Val
        1795                1800                1805
Gly Arg Tyr Cys Gly Asn Ser Phe Pro Leu Asn Tyr Ser Ser Ile Val
    1810                1815                1820
Gly His Thr Leu Trp Val Arg Phe Ile Ser Asp Gly Ser Gly Ser Gly
1825                1830                1835                1840
Thr Gly Phe Gln Ala Thr Phe Met Lys Ile Phe Gly Asn Asp Asn Ile
                1845                1850                1855
Val Gly Thr His Gly Lys Val Ala Ser Pro Phe Trp Pro Glu Asn Tyr
            1860                1865                1870
Pro His Asn Ser Asn Tyr Gln Trp Thr Val Asn Val Asn Ala Ser His
        1875                1880                1885
Val Val His Gly Arg Ile Leu Glu Met Asp Ile Glu Glu Ile Gln Asn
    1890                1895                1900
Cys Tyr Tyr Asp Lys Leu Arg Ile Tyr Asp Gly Pro Ser Ile His Ala
1905                1910                1915                1920
Arg Leu Ile Gly Ala Tyr Cys Gly Thr Gln Thr Glu Ser Phe Ser Ser
                1925                1930                1935
Thr Gly Asn Ser Leu Thr Phe His Phe Tyr Ser Asp Ser Ser Ile Ser
            1940                1945                1950
Gly Lys Gly Phe Leu Leu Glu Trp Phe Ala Val Asp Ala Pro Asp Gly
        1955                1960                1965
Val Leu Pro Thr Ile Ala Pro Gly Ala Cys Gly Gly Phe Leu Arg Thr
    1970                1975                1980
Gly Asp Ala Pro Val Phe Leu Phe Ser Pro Gly Trp Pro Asp Ser Tyr
1985                1990                1995                2000
Ser Asn Arg Val Asp Cys Thr Trp Leu Ile Gln Ala Pro Asp Ser Thr
                2005                2010                2015
Val Glu Leu Asn Ile Leu Ser Leu Asp Ile Glu Ser His Arg Thr Cys
            2020                2025                2030
Ala Tyr Asp Ser Leu Val Ile Arg Asp Gly Asp Asn Asn Leu Ala Gln
        2035                2040                2045
Gln Leu Ala Val Leu Cys Gly Arg Glu Ile Pro Gly Pro Ile Arg Ser
    2050                2055                2060
Thr Gly Glu Tyr Met Phe Ile Arg Phe Thr Ser Asp Ser Ser Val Thr
2065                2070                2075                2080
Arg Ala Gly Phe Asn Ala Ser Phe His Lys Ser Cys Gly Gly Tyr Leu
                2085                2090                2095
His Ala Asp Arg Gly Ile Ile Thr Ser Pro Lys Tyr Pro Glu Thr Tyr
            2100                2105                2110
Pro Ser Asn Leu Asn Cys Ser Trp His Val Leu Val Gln Ser Gly Leu
        2115                2120                2125
Thr Ile Ala Val His Phe Glu Gln Pro Phe Gln Ile Pro Asn Gly Asp
    2130                2135                2140
Ser Ser Cys Asn Gln Gly Asp Tyr Leu Val Leu Arg Asn Gly Pro Asp
2145                2150                2155                2160
Ile Tyr Ser Pro Pro Leu Gly Pro Pro Gly Gly Asn Gly His Phe Cys
                2165                2170                2175
Gly Ser His Ala Ser Ser Thr Leu Phe Thr Ser Asp Asn Gln Met Phe
            2180                2185                2190
Val Gln Phe Ile Ser Asp His Ser Asn Glu Gly Gln Gly Phe Lys Ile
        2195                2200                2205
Lys Tyr Glu Ala Lys Ser Leu Ala Cys Gly Gly Asn Val Tyr Ile His
    2210                2215                2220
Asp Ala Asp Ser Ala Gly Tyr Val Thr Ser Pro Asn His Pro His Asn
2225                2230                2235                2240
Tyr Pro Pro His Ala Asp Cys Ile Trp Ile Leu Ala Ala Pro Pro Glu
                2245                2250                2255
Thr Arg Ile Gln Leu Gln Phe Glu Asp Arg Phe Asp Ile Glu Val Thr
            2260                2265                2270
Pro Asn Cys Thr Ser Asn Tyr Leu Glu Leu Arg Asp Gly Val Asp Ser
        2275                2280                2285
Asp Ala Pro Ile Leu Ser Lys Phe Cys Gly Thr Ser Leu Pro Ser Ser
    2290                2295                2300
Gln Trp Ser Ser Gly Glu Val Met Tyr Leu Arg Phe Arg Ser Asp Asn
2305                2310                2315                2320
Ser Pro Thr His Val Gly Phe Lys Ala Lys Tyr Ser Ile Ala Gln Cys
                2325                2330                2335
Gly Gly Arg Val Pro Gly Gln Ser Gly Val Val Glu Ser Ile Gly His
            2340                2345                2350
Pro Thr Leu Pro Tyr Arg Asp Asn Leu Phe Cys Glu Trp His Leu Gln
        2355                2360                2365
Gly Leu Ser Gly His Tyr Leu Thr Ile Ser Phe Glu Asp Phe Asn Leu
    2370                2375                2380
Gln Asn Ser Ser Gly Cys Glu Lys Asp Phe Val Glu Ile Trp Asp Asn
2385                2390                2395                2400
His Thr Ser Gly Asn Ile Leu Gly Arg Tyr Cys Gly Asn Thr Ile Pro
                2405                2410                2415
Asp Ser Ile Asp Thr Ser Ser Asn Thr Ala Val Val Arg Phe Val Thr
            2420                2425                2430
Asp Gly Ser Val Thr Ala Ser Gly Phe Arg Leu Arg Phe Glu Ser Ser
        2435                2440                2445
Met Glu Glu Cys Gly Gly Asp Leu Gln Gly Ser Ile Gly Thr Phe Thr
    2450                2455                2460
Ser Pro Asn Tyr Pro Asn Pro Asn Pro His Gly Arg Ile Cys Glu Trp
2465                2470                2475                2480
Arg Ile Thr Ala Pro Glu Gly Arg Arg Ile Thr Leu Met Phe Asn Asn
                2485                2490                2495
Leu Arg Leu Ala Thr His Pro Ser Cys Asn Asn Glu His Val Ile Val
            2500                2505                2510
Phe Asn Gly Ile Arg Ser Asn Ser Pro Gln Leu Glu Lys Leu Cys Ser
        2515                2520                2525
Ser Val Asn Val Ser Asn Glu Ile Lys Ser Ser Gly Asn Thr Met Lys
    2530                2535                2540
Val Ile Phe Phe Thr Asp Gly Ser Arg Pro Tyr Gly Gly Phe Thr Ala
2545                2550                2555                2560
Ser Tyr Thr Ser Ser Glu Asp Ala Val Cys Gly Gly Ser Leu Pro Asn
                2565                2570                2575
Thr Pro Glu Gly Asn Phe Thr Ser Pro Gly Tyr Asp Gly Val Arg Asn
            2580                2585                2590
Tyr Ser Arg Asn Leu Asn Cys Glu Trp Thr Leu Ser Asn Pro Asn Gln
        2595                2600                2605
Gly Asn Ser Ser Ile Ser Ile His Phe Glu Asp Phe Tyr Leu Glu Ser
    2610                2615                2620
His Gln Asp Cys Gln Phe Asp Val Leu Glu Phe Arg Val Gly Asp Ala
2625                2630                2635                2640
Asp Gly Pro Leu Met Trp Arg Leu Cys Gly Pro Ser Lys Pro Thr Leu
                2645                2650                2655
Pro Leu Val Ile Pro Tyr Ser Gln Val Trp Ile His Phe Val Thr Asn
            2660                2665                2670
Glu Arg Val Glu His Ile Gly Phe His Ala Lys Tyr Ser Phe Thr Asp
        2675                2680                2685
Cys Gly Gly Ile Gln Ile Gly Asp Ser Gly Val Ile Thr Ser Pro Asn
    2690                2695                2700
Tyr Pro Asn Ala Tyr Asp Ser Leu Thr His Cys Ser Trp Leu Leu Glu
2705                2710                2715                2720
Ala Pro Gln Gly His Thr Ile Thr Leu Thr Phe Ser Asp Phe Asp Ile
                2725                2730                2735
Glu Pro His Thr Thr Cys Ala Trp Asp Ser Val Thr Val Arg Asn Gly
            2740                2745                2750
Gly Ser Pro Glu Ser Pro Ile Ile Gly Gln Tyr Cys Gly Asn Ser Asn
        2755                2760                2765
Pro Arg Thr Ile Gln Ser Gly Ser Asn Gln Leu Val Val Thr Phe Asn
    2770                2775                2780
Ser Asp His Ser Leu Gln Gly Gly Gly Phe Tyr Ala Thr Trp Asn Thr
2785                2790                2795                2800
Gln Thr Leu Gly Cys Gly Gly Ile Phe His Ser Asp Asn Gly Thr Ile
                2805                2810                2815
Arg Ser Pro His Trp Pro Gln Asn Phe Pro Glu Asn Ser Arg Cys Ser
            2820                2825                2830
Trp Thr Ala Ile Thr His Lys Ser Lys His Leu Glu Ile Ser Phe Asp
        2835                2840                2845
Asn Asn Phe Leu Ile Pro Ser Gly Asp Gly Gln Cys Gln Asn Ser Phe
    2850                2855                2860
Val Lys Val Trp Ala Gly Thr Glu Glu Val Asp Lys Ala Leu Leu Ala
2865                2870                2875                2880
Thr Gly Cys Gly Asn Val Ala Pro Gly Pro Val Ile Thr Pro Ser Asn
                2885                2890                2895
Thr Phe Thr Ala Val Phe Gln Ser Gln Glu Ala Pro Ala Gln Gly Phe
            2900                2905                2910
Ser Ala Ser Phe Val Ser Arg Cys Gly Ser Asn Phe Thr Gly Pro Ser
        2915                2920                2925
Gly Tyr Ile Ile Ser Pro Asn Tyr Pro Lys Gln Tyr Asp Asn Asn Met
    2930                2935                2940
Asn Cys Thr Tyr Val Ile Glu Ala Asn Pro Leu Ser Val Val Leu Leu
2945                2950                2955                2960
Thr Phe Val Ser Phe His Leu Glu Ala Arg Ser Ala Val Thr Gly Ser
                2965                2970                2975
Cys Val Asn Asp Gly Val His Ile Ile Arg Gly Tyr Ser Val Met Ser
            2980                2985                2990
Thr Pro Phe Ala Thr Val Cys Gly Asp Glu Met Pro Ala Pro Leu Thr
        2995                3000                3005
Ile Ala Gly Pro Val Leu Leu Asn Phe Tyr Ser Asn Glu Gln Ile Thr
    3010                3015                3020
Asp Phe Gly Phe Lys Phe Ser Tyr Arg Ile Ile Ser Cys Gly Gly Val
3025                3030                3035                3040
Phe Asn Phe Ser Ser Gly Ile Ile Thr Ser Pro Ala Tyr Ser Tyr Ala
                3045                3050                3055
Asp Tyr Pro Asn Asp Met His Cys Leu Tyr Thr Ile Thr Val Ser Asp
            3060                3065                3070
Asp Lys Val Ile Glu Leu Lys Phe Ser Asp Phe Asp Val Val Pro Ser
        3075                3080                3085
Thr Ser Cys Ser His Asp Tyr Leu Ala Ile Tyr Asp Gly Ala Asn Thr
    3090                3095                3100
Ser Asp Pro Leu Leu Gly Lys Phe Cys Gly Ser Lys Arg Pro Pro Asn
3105                3110                3115                3120
Val Lys Ser Ser Asn Asn Ser Met Leu Leu Val Phe Lys Thr Asp Ser
                3125                3130                3135
Phe Gln Thr Ala Lys Gly Trp Lys Met Ser Phe Arg Gln Thr Leu Gly
            3140                3145                3150
Pro Gln Gln Gly Cys Gly Gly Tyr Leu Thr Gly Ser Asn Asn Thr Phe
        3155                3160                3165
Ala Ser Pro Asp Ser Asp Ser Asn Gly Met Tyr Asp Lys Asn Leu Asn
    3170                3175                3180
Cys Val Trp Ile Ile Ile Ala Pro Val Asn Lys Val Ile His Leu Thr
3185                3190                3195                3200
Phe Asn Thr Phe Ala Leu Glu Ala Ala Ser Thr Arg Gln Arg Cys Leu
                3205                3210                3215
Tyr Asp Tyr Val Lys Leu Tyr Asp Gly Asp Ser Glu Asn Ala Asn Leu
            3220                3225                3230
Ala Gly Thr Phe Cys Gly Ser Thr Val Pro Ala Pro Phe Ile Ser Ser
        3235                3240                3245
Gly Asn Phe Leu Thr Val Gln Phe Ile Ser Asp Leu Thr Leu Glu Arg
    3250                3255                3260
Glu Gly Phe Asn Ala Thr Tyr Thr Ile Met Asp Met Pro Cys Gly Gly
3265                3270                3275                3280
Thr Tyr Asn Ala Thr Trp Thr Pro Gln Asn Ile Ser Ser Pro Asn Ser
                3285                3290                3295
Ser Asp Pro Asp Val Pro Phe Ser Ile Cys Thr Trp Val Ile Asp Ser
            3300                3305                3310
Pro Pro His Gln Gln Val Lys Ile Thr Val Trp Ala Leu Gln Leu Thr
        3315                3320                3325
Ser Gln Asp Cys Thr Gln Asn Tyr Leu Gln Leu Gln Asp Ser Pro Gln
    3330                3335                3340
Gly His Gly Asn Ser Arg Phe Gln Phe Cys Gly Arg Asn Ala Ser Ala
3345                3350                3355                3360
Val Pro Val Phe Tyr Ser Ser Met Ser Thr Ala Met Val Ile Phe Lys
                3365                3370                3375
Ser Gly Val Val Asn Arg Asn Ser Arg Met Ser Phe Thr Tyr Gln Ile
            3380                3385                3390
Ala Asp Cys Asn Arg Asp Tyr His Lys Ala Phe Gly Asn Leu Arg Ser
        3395                3400                3405
Pro Gly Trp Pro Asp Asn Tyr Asp Asn Asp Lys Asp Cys Thr Val Thr
    3410                3415                3420
Leu Thr Ala Pro Gln Asn His Thr Ile Ser Leu Phe Phe His Ser Leu
3425                3430                3435                3440
Gly Ile Glu Asn Ser Val Glu Cys Arg Asn Asp Phe Leu Glu Val Arg
                3445                3450                3455
Asn Gly Ser Asn Ser Asn Ser Pro Leu Leu Gly Lys Tyr Cys Gly Thr
            3460                3465                3470
Leu Leu Pro Asn Pro Val Phe Ser Gln Asn Asn Glu Leu Tyr Leu Arg
        3475                3480                3485
Phe Lys Ser Asp Ser Val Thr Ser Asp Arg Gly Tyr Glu Ile Ile Trp
    3490                3495                3500
Thr Ser Ser Pro Ser Gly Cys Gly Gly Thr Leu Tyr Gly Asp Arg Gly
3505                3510                3515                3520
Ser Phe Thr Ser Pro Gly Tyr Pro Gly Thr Tyr Pro Asn Asn Thr Tyr
                3525                3530                3535
Cys Glu Trp Val Leu Val Ala Pro Ala Gly Arg Leu Val Thr Ile Asn
            3540                3545                3550
Phe Tyr Phe Ile Ser Ile Asp Asp Pro Gly Asp Cys Val Gln Asn Tyr
        3555                3560                3565
Leu Thr Leu Tyr Asp Gly Pro Asn Ala Ser Ser Pro Ser Ser Gly Pro
    3570                3575                3580
Tyr Cys Gly Gly Asp Thr Ser Ile Ala Pro Phe Val Ala Ser Ser Asn
3585                3590                3595                3600
Gln Val Phe Ile Lys Phe His Ala Asp Tyr Ala Arg Arg Pro Ser Ala
                3605                3610                3615
Phe Arg Leu Thr Trp Asp Ser
            3620

<210> 699
<211> 350
<212> PRT
<213> Homo sapiens

<400> 699
Met Asp Met Pro Cys Gly Gly Thr Tyr Asn Ala Thr Trp Thr Pro Gln
 1               5                  10                  15
Asn Ile Ser Ser Pro Asn Ser Ser Asp Pro Asp Val Pro Phe Ser Ile
            20                  25                  30
Cys Thr Trp Val Ile Asp Ser Pro Pro His Gln Gln Val Lys Ile Thr
        35                  40                  45
Val Trp Ala Leu Gln Leu Thr Ser Gln Asp Cys Thr Gln Asn Tyr Leu
    50                  55                  60
Gln Leu Gln Asp Ser Pro Gln Gly His Gly Asn Ser Arg Phe Gln Phe
65                  70                  75                  80
Cys Gly Arg Asn Ala Ser Ala Val Pro Val Phe Tyr Ser Ser Met Ser
                85                  90                  95
Thr Ala Met Val Ile Phe Lys Ser Gly Val Val Asn Arg Asn Ser Arg
            100                 105                 110
Met Ser Phe Thr Tyr Gln Ile Ala Asp Cys Asn Arg Asp Tyr His Lys
        115                 120                 125
Ala Phe Gly Asn Leu Arg Ser Pro Gly Trp Pro Asp Asn Tyr Asp Asn
    130                 135                 140
Asp Lys Asp Cys Thr Val Thr Leu Thr Ala Pro Gln Asn His Thr Ile
145                 150                 155                 160
Ser Leu Phe Phe His Ser Leu Gly Ile Glu Asn Ser Val Glu Cys Arg
                165                 170                 175
Asn Asp Phe Leu Glu Val Arg Asn Gly Ser Asn Ser Asn Ser Pro Leu
            180                 185                 190
Leu Gly Lys Tyr Cys Gly Thr Leu Leu Pro Asn Pro Val Phe Ser Gln
        195                 200                 205
Asn Asn Glu Leu Tyr Leu Arg Phe Lys Ser Asp Ser Val Thr Ser Asp
    210                 215                 220
Arg Gly Tyr Glu Ile Ile Trp Thr Ser Ser Pro Ser Gly Cys Gly Gly
225                 230                 235                 240
Thr Leu Tyr Gly Asp Arg Gly Ser Phe Thr Ser Pro Gly Tyr Pro Gly
                245                 250                 255
Thr Tyr Pro Asn Asn Thr Tyr Cys Glu Trp Val Leu Val Ala Pro Ala
            260                 265                 270
Gly Arg Leu Val Thr Ile Asn Phe Tyr Phe Ile Ser Ile Asp Asp Pro
        275                 280                 285
Gly Asp Cys Val Gln Asn Tyr Leu Thr Leu Tyr Asp Gly Pro Asn Ala
    290                 295                 300
Ser Ser Pro Ser Ser Gly Pro Tyr Cys Gly Gly Asp Thr Ser Ile Ala
305                 310                 315                 320
Pro Phe Val Ala Ser Ser Asn Gln Val Phe Ile Lys Phe His Ala Asp
                325                 330                 335
Tyr Ala Arg Arg Pro Ser Ala Phe Arg Leu Thr Trp Asp Ser
            340                 345                 350

<210> 700
<211> 464
<212> PRT
<213> Homo sapiens

<400> 700
Met Ser His Ser Trp Asn Val Leu Trp Leu Thr Phe Cys Ser Asp Ser
 1               5                  10                  15
Asn Gly Met Tyr Asp Lys Asn Leu Asn Cys Val Trp Ile Ile Ile Ala
            20                  25                  30
Pro Val Asn Lys Val Ile His Leu Thr Phe Asn Thr Phe Ala Leu Glu
        35                  40                  45
Ala Ala Ser Thr Arg Gln Arg Cys Leu Tyr Asp Tyr Val Lys Leu Tyr
    50                  55                  60
Asp Gly Asp Ser Glu Asn Ala Asn Leu Ala Gly Thr Phe Cys Gly Ser
65                  70                  75                  80
Thr Val Pro Ala Pro Phe Ile Ser Ser Gly Asn Phe Leu Thr Val Gln
                85                  90                  95
Phe Ile Ser Asp Leu Thr Leu Glu Arg Glu Gly Phe Asn Ala Thr Tyr
            100                 105                 110
Thr Ile Met Asp Met Pro Cys Gly Gly Thr Tyr Asn Ala Thr Trp Thr
        115                 120                 125
Pro Gln Asn Ile Ser Ser Pro Asn Ser Ser Asp Pro Asp Val Pro Phe
    130                 135                 140
Ser Ile Cys Thr Trp Val Ile Asp Ser Pro Pro His Gln Gln Val Lys
145                 150                 155                 160
Ile Thr Val Trp Ala Leu Gln Leu Thr Ser Gln Asp Cys Thr Gln Asn
                165                 170                 175
Tyr Leu Gln Leu Gln Asp Ser Pro Gln Gly His Gly Asn Ser Arg Phe
            180                 185                 190
Gln Phe Cys Gly Arg Asn Ala Ser Ala Val Pro Val Phe Tyr Ser Ser
        195                 200                 205
Met Ser Thr Ala Met Val Ile Phe Lys Ser Gly Val Val Asn Arg Asn
    210                 215                 220
Ser Arg Met Ser Phe Thr Tyr Gln Ile Ala Asp Cys Asn Arg Asp Tyr
225                 230                 235                 240
His Lys Ala Phe Gly Asn Leu Arg Ser Pro Gly Trp Pro Asp Asn Tyr
                245                 250                 255
Asp Asn Asp Lys Asp Cys Thr Val Thr Leu Thr Ala Pro Gln Asn His
            260                 265                 270
Thr Ile Ser Leu Phe Phe His Ser Leu Gly Ile Glu Asn Ser Val Glu
        275                 280                 285
Cys Arg Asn Asp Phe Leu Glu Val Arg Asn Gly Ser Asn Ser Asn Ser
    290                 295                 300
Pro Leu Leu Gly Lys Tyr Cys Gly Thr Leu Leu Pro Asn Pro Val Phe
305                 310                 315                 320
Ser Gln Asn Ser Glu Leu Tyr Leu Arg Phe Lys Ser Asp Ser Val Thr
                325                 330                 335
Ser Asp Arg Gly Tyr Glu Ile Ile Trp Thr Ser Ser Pro Ser Gly Cys
            340                 345                 350
Gly Gly Thr Leu Tyr Gly Asp Arg Gly Ser Phe Thr Ser Pro Gly Tyr
        355                 360                 365
Pro Gly Thr Tyr Pro Asn Asn Thr Tyr Cys Glu Trp Val Leu Val Ala
    370                 375                 380
Pro Ala Gly Arg Leu Val Thr Ile Asn Leu Tyr Phe Ile Ser Ile Asp
385                 390                 395                 400
Asp Pro Gly Asp Cys Val Gln Asn Tyr Leu Thr Leu Tyr Asp Gly Pro
                405                 410                 415
Asn Ala Ser Ser Pro Ser Ser Gly Pro Tyr Cys Gly Gly Asp Thr Ser
            420                 425                 430
Ile Ala Pro Phe Val Ala Ser Ser Asn Gln Val Phe Ile Lys Phe His
        435                 440                 445
Ala Asp Tyr Ala Arg Arg Pro Ser Ala Phe Arg Leu Thr Trp Asp Ser
    450                 455                 460

<210> 701
<211> 3623
<212> PRT
<213> Homo sapiens

<400> 701
Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu
 1               5                  10                  15
Ile Phe Ala Glu Val Asn Gly Glu Arg Gly Glu Leu Glu Leu Gln Arg
            20                  25                  30
Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg
        35                  40                  45
Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg
    50                  55                  60
Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu
65                  70                  75                  80
Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys
                85                  90                  95
Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln
            100                 105                 110
Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln
        115                 120                 125
Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly
    130                 135                 140
Gly Asn Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro
145                 150                 155                 160
Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile
                165                 170                 175
Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn
            180                 185                 190
Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro
        195                 200                 205
Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg
    210                 215                 220
Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu
225                 230                 235                 240
Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Ser Ser Pro Asn
                245                 250                 255
Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly
            260                 265                 270
Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr
        275                 280                 285
Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu
    290                 295                 300
Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro
305                 310                 315                 320
Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys
                325                 330                 335
Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile
            340                 345                 350
Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser
        355                 360                 365
Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly
    370                 375                 380
Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu
385                 390                 395                 400
Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr
                405                 410                 415
Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn
            420                 425                 430
Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val
        435                 440                 445
Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly
    450                 455                 460
Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly
465                 470                 475                 480
Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His
                485                 490                 495
Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu
            500                 505                 510
Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro
        515                 520                 525
His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln
    530                 535                 540
Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser
545                 550                 555                 560
Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly
                565                 570                 575
Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly
            580                 585                 590
Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly
        595                 600                 605
Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro
    610                 615                 620
Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His
625                 630                 635                 640
Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr
                645                 650                 655
Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro
            660                 665                 670
Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser
        675                 680                 685
Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser
    690                 695                 700
Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe
705                 710                 715                 720
Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr
                725                 730                 735
Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His
            740                 745                 750
Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val
        755                 760                 765
Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile
    770                 775                 780
Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile
785                 790                 795                 800
Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala
                805                 810                 815
Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe
            820                 825                 830
Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln
        835                 840                 845
Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly
    850                 855                 860
Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser
865                 870                 875                 880
Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro
                885                 890                 895
Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys
            900                 905                 910
Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu
        915                 920                 925
Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln
    930                 935                 940
Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp
945                 950                 955                 960
His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr
                965                 970                 975
Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val
            980                 985                 990
Tyr Asp Thr Asp Ser Glu Thr Ser Leu Gly Arg Tyr Cys Gly Lys Ser
        995                 1000                1005
Ile Pro Pro Ser Leu Thr Ser Ser Gly Asn Ser Leu Met Leu Val Phe
    1010                1015                1020
Val Thr Asp Ser Asp Leu Ala Tyr Glu Gly Phe Leu Ile Asn Tyr Glu
1025                1030                1035                1040
Ala Ile Ser Ala Ala Thr Ala Cys Leu Gln Asp Tyr Thr Asp Asp Leu
                1045                1050                1055
Gly Thr Phe Thr Ser Pro Asn Phe Pro Asn Asn Tyr Pro Asn Asn Trp
            1060                1065                1070
Glu Cys Ile Tyr Arg Ile Thr Val Arg Thr Gly Gln Leu Ile Ala Val
        1075                1080                1085
His Phe Thr Asn Phe Ser Leu Glu Glu Ala Ile Gly Asn Tyr Tyr Thr
    1090                1095                1100
Asp Phe Leu Glu Ile Arg Asp Gly Gly Tyr Glu Lys Ser Pro Leu Leu
1105                1110                1115                1120
Gly Ile Phe Tyr Gly Ser Asn Leu Pro Pro Thr Ile Ile Ser His Ser
                1125                1130                1135
Asn Lys Leu Trp Leu Lys Phe Lys Ser Asp Gln Ile Asp Thr Arg Ser
            1140                1145                1150
Gly Phe Ser Ala Tyr Trp Asp Gly Ser Ser Thr Gly Cys Gly Gly Asn
        1155                1160                1165
Leu Thr Thr Ser Ser Gly Thr Phe Ile Ser Pro Asn Tyr Pro Met Pro
    1170                1175                1180
Tyr Tyr His Ser Ser Glu Cys Tyr Trp Trp Leu Lys Ser Ser His Gly
1185                1190                1195                1200
Ser Ala Phe Glu Leu Glu Phe Lys Asp Phe His Leu Glu His His Pro
                1205                1210                1215
Asn Cys Thr Leu Asp Tyr Leu Ala Val Tyr Asp Gly Pro Ser Ser Asn
            1220                1225                1230
Ser His Leu Leu Thr Gln Leu Cys Gly Asp Glu Lys Pro Pro Leu Ile
        1235                1240                1245
Arg Ser Ser Gly Asp Ser Met Phe Ile Lys Leu Arg Thr Asp Glu Gly
    1250                1255                1260
Gln Gln Gly Arg Gly Phe Lys Ala Glu Tyr Arg Gln Thr Cys Glu Asn
1265                1270                1275                1280
Val Val Ile Val Asn Gln Thr Tyr Gly Ile Leu Glu Ser Ile Gly Tyr
                1285                1290                1295
Pro Asn Pro Tyr Ser Glu Asn Gln His Cys Asn Trp Thr Ile Arg Ala
            1300                1305                1310
Thr Thr Gly Asn Thr Val Asn Tyr Thr Phe Leu Ala Phe Asp Leu Glu
        1315                1320                1325
His His Ile Asn Cys Ser Thr Asp Tyr Leu Glu Leu Tyr Asp Gly Pro
    1330                1335                1340
Arg Gln Met Gly Arg Tyr Cys Gly Val Asp Leu Pro Pro Pro Gly Ser
1345                1350                1355                1360
Thr Thr Ser Ser Lys Leu Gln Val Leu Leu Leu Thr Asp Gly Val Gly
                1365                1370                1375
Arg Arg Glu Lys Gly Phe Gln Met Gln Trp Phe Val Tyr Gly Cys Gly
            1380                1385                1390
Gly Glu Leu Ser Gly Ala Thr Gly Ser Phe Ser Ser Pro Gly Phe Pro
        1395                1400                1405
Asn Arg Tyr Pro Pro Asn Lys Glu Cys Ile Trp Tyr Ile Arg Thr Asp
    1410                1415                1420
Pro Gly Ser Ser Ile Gln Leu Thr Ile His Asp Phe Asp Val Glu Tyr
1425                1430                1435                1440
His Ser Arg Cys Asn Phe Asp Val Leu Glu Ile Tyr Gly Gly Pro Asp
                1445                1450                1455
Phe His Ser Pro Arg Ile Ala Gln Leu Cys Thr Gln Arg Ser Pro Glu
            1460                1465                1470
Asn Pro Met Gln Val Ser Ser Thr Gly Asn Glu Leu Ala Ile Arg Phe
        1475                1480                1485
Lys Thr Asp Leu Ser Ile Asn Gly Arg Gly Phe Asn Ala Ser Trp Gln
    1490                1495                1500
Ala Val Thr Gly Gly Cys Gly Gly Ile Phe Gln Ala Pro Ser Gly Glu
1505                1510                1515                1520
Ile His Ser Pro Asn Tyr Pro Ser Pro Tyr Arg Ser Asn Thr Asp Cys
                1525                1530                1535
Ser Trp Val Ile Arg Val Asp Arg Tyr His Arg Val Leu Leu Asn Phe
            1540                1545                1550
Thr Asp Phe Asp Leu Glu Pro Gln Asp Ser Cys Ile Met Ala Tyr Asp
        1555                1560                1565
Gly Leu Ser Ser Thr Met Ser Arg Leu Ala Arg Thr Cys Gly Arg Glu
    1570                1575                1580
Gln Leu Ala Asn Pro Ile Val Ser Ser Gly Asn Ser Leu Phe Leu Arg
1585                1590                1595                1600
Phe Gln Ser Gly Pro Ser Arg Gln Asn Arg Gly Phe Arg Ala Gln Phe
                1605                1610                1615
Arg Gln Ala Cys Gly Gly His Ile Leu Thr Ser Ser Phe Asp Thr Val
            1620                1625                1630
Ser Ser Pro Arg Phe Pro Ala Asn Tyr Pro Asn Asn Gln Asn Cys Ser
        1635                1640                1645
Trp Ile Ile Gln Ala Gln Pro Pro Leu Asn His Ile Thr Leu Ser Phe
    1650                1655                1660
Thr His Phe Glu Leu Glu Arg Ser Thr Thr Cys Ala Arg Asp Phe Val
1665                1670                1675                1680
Glu Ile Leu Asp Gly Gly His Glu Asp Ala Pro Leu Arg Gly Arg Tyr
                1685                1690                1695
Cys Gly Thr Asp Met Pro His Pro Ile Thr Ser Phe Ser Ser Ala Leu
            1700                1705                1710
Thr Leu Arg Phe Val Ser Asp Ser Ser Ile Ser Ala Gly Gly Phe His
        1715                1720                1725
Thr Thr Val Thr Ala Ser Val Ser Ala Cys Gly Gly Thr Phe Tyr Met
    1730                1735                1740
Ala Glu Gly Ile Phe Asn Ser Pro Gly Tyr Pro Asp Ile Tyr Pro Pro
1745                1750                1755                1760
Asn Val Glu Cys Val Trp Asn Ile Ile Ser Ser Pro Gly Asn Arg Leu
                1765                1770                1775
Gln Leu Ser Phe Ile Ser Phe Gln Leu Glu Asp Ser Gln Asp Cys Ser
            1780                1785                1790
Arg Asp Phe Val Glu Ile Arg Glu Gly Asn Ala Thr Gly His Leu Val
        1795                1800                1805
Gly Arg Tyr Cys Gly Asn Ser Phe Pro Leu Asn Tyr Ser Ser Ile Val
    1810                1815                1820
Gly His Thr Leu Trp Val Arg Phe Ile Ser Asp Gly Ser Gly Ser Gly
1825                1830                1835                1840
Thr Gly Phe Gln Ala Thr Phe Met Lys Ile Phe Gly Asn Asp Asn Ile
                1845                1850                1855
Val Gly Thr His Gly Lys Val Ala Ser Pro Phe Trp Pro Glu Asn Tyr
            1860                1865                1870
Pro His Asn Ser Asn Tyr Gln Trp Thr Val Asn Val Asn Ala Ser His
        1875                1880                1885
Val Val His Gly Arg Ile Leu Glu Met Asp Ile Glu Glu Ile Gln Asn
    1890                1895                1900
Cys Tyr Tyr Asp Lys Leu Arg Ile Tyr Asp Gly Pro Ser Ile His Ala
1905                1910                1915                1920
Arg Leu Ile Gly Ala Tyr Cys Gly Thr Gln Thr Glu Ser Phe Ser Ser
                1925                1930                1935
Thr Gly Asn Ser Leu Thr Phe His Phe Tyr Ser Asp Ser Ser Ile Ser
            1940                1945                1950
Gly Lys Gly Phe Leu Leu Glu Trp Phe Ala Val Asp Ala Pro Asp Gly
        1955                1960                1965
Val Leu Pro Thr Ile Ala Pro Gly Ala Cys Gly Gly Phe Leu Arg Thr
    1970                1975                1980
Gly Asp Ala Pro Val Phe Leu Phe Ser Pro Gly Trp Pro Asp Ser Tyr
1985                1990                1995                2000
Ser Asn Arg Val Asp Cys Thr Trp Leu Ile Gln Ala Pro Asp Ser Thr
                2005                2010                2015
Val Glu Leu Asn Ile Leu Ser Leu Asp Ile Glu Ser His Arg Thr Cys
            2020                2025                2030
Ala Tyr Asp Ser Leu Val Ile Arg Asp Gly Asp Asn Asn Leu Ala Gln
        2035                2040                2045
Gln Leu Ala Val Leu Cys Gly Arg Glu Ile Pro Gly Pro Ile Arg Ser
    2050                2055                2060
Thr Gly Glu Tyr Met Phe Ile Arg Phe Thr Ser Asp Ser Ser Val Thr
2065                2070                2075                2080
Arg Ala Gly Phe Asn Ala Ser Phe His Lys Ser Cys Gly Gly Tyr Leu
                2085                2090                2095
His Ala Asp Arg Gly Ile Ile Thr Ser Pro Lys Tyr Pro Glu Thr Tyr
            2100                2105                2110
Pro Ser Asn Leu Asn Cys Ser Trp His Val Leu Val Gln Ser Gly Leu
        2115                2120                2125
Thr Ile Ala Val His Phe Glu Gln Pro Phe Gln Ile Pro Asn Gly Asp
    2130                2135                2140
Ser Ser Cys Asn Gln Gly Asp Tyr Leu Val Leu Arg Asn Gly Pro Asp
2145                2150                2155                2160
Ile Tyr Ser Pro Pro Leu Gly Pro Pro Gly Gly Asn Gly His Phe Cys
                2165                2170                2175
Gly Ser His Ala Ser Ser Thr Leu Phe Thr Ser Asp Asn Gln Met Phe
            2180                2185                2190
Val Gln Phe Ile Ser Asp His Ser Asn Glu Gly Gln Gly Phe Lys Ile
        2195                2200                2205
Lys Tyr Glu Ala Lys Ser Leu Ala Cys Gly Gly Asn Val Tyr Ile His
    2210                2215                2220
Asp Ala Asp Ser Ala Gly Tyr Val Thr Ser Pro Asn His Pro His Asn
2225                2230                2235                2240
Tyr Pro Pro His Ala Asp Cys Ile Trp Ile Leu Ala Ala Pro Pro Glu
                2245                2250                2255
Thr Arg Ile Gln Leu Gln Phe Glu Asp Arg Phe Asp Ile Glu Val Thr
            2260                2265                2270
Pro Asn Cys Thr Ser Asn Tyr Leu Glu Leu Arg Asp Gly Val Asp Ser
        2275                2280                2285
Asp Ala Pro Ile Leu Ser Lys Phe Cys Gly Thr Ser Leu Pro Ser Ser
    2290                2295                2300
Gln Trp Ser Ser Gly Glu Val Met Tyr Leu Arg Phe Arg Ser Asp Asn
2305                2310                2315                2320
Ser Pro Thr His Val Gly Phe Lys Ala Lys Tyr Ser Ile Ala Gln Cys
                2325                2330                2335
Gly Gly Arg Val Pro Gly Gln Ser Gly Val Val Glu Ser Ile Gly His
            2340                2345                2350
Pro Thr Leu Pro Tyr Arg Asp Asn Leu Phe Cys Glu Trp His Leu Gln
        2355                2360                2365
Gly Leu Ser Gly His Tyr Leu Thr Ile Ser Phe Glu Asp Phe Asn Leu
    2370                2375                2380
Gln Asn Ser Ser Gly Cys Glu Lys Asp Phe Val Glu Ile Trp Asp Asn
2385                2390                2395                2400
His Thr Ser Gly Asn Ile Leu Gly Arg Tyr Cys Gly Asn Thr Ile Pro
                2405                2410                2415
Asp Ser Ile Asp Thr Ser Ser Asn Thr Ala Val Val Arg Phe Val Thr
            2420                2425                2430
Asp Gly Ser Val Thr Ala Ser Gly Phe Arg Leu Arg Phe Glu Ser Ser
        2435                2440                2445
Met Glu Glu Cys Gly Gly Asp Leu Gln Gly Ser Ile Gly Thr Phe Thr
    2450                2455                2460
Ser Pro Asn Tyr Pro Asn Pro Asn Pro His Gly Arg Ile Cys Glu Trp
2465                2470                2475                2480
Arg Ile Thr Ala Pro Glu Gly Arg Arg Ile Thr Leu Met Phe Asn Asn
                2485                2490                2495
Leu Arg Leu Ala Thr His Pro Ser Cys Asn Asn Glu His Val Ile Val
            2500                2505                2510
Phe Asn Gly Ile Arg Ser Asn Ser Pro Gln Leu Glu Lys Leu Cys Ser
        2515                2520                2525
Ser Val Asn Val Ser Asn Glu Ile Lys Ser Ser Gly Asn Thr Met Lys
    2530                2535                2540
Val Ile Phe Phe Thr Asp Gly Ser Arg Pro Tyr Gly Gly Phe Thr Ala
2545                2550                2555                2560
Ser Tyr Thr Ser Ser Glu Asp Ala Val Cys Gly Gly Ser Leu Pro Asn
                2565                2570                2575
Thr Pro Glu Gly Asn Phe Thr Ser Pro Gly Tyr Asp Gly Val Arg Asn
            2580                2585                2590
Tyr Ser Arg Asn Leu Asn Cys Glu Trp Thr Leu Ser Asn Pro Asn Gln
        2595                2600                2605
Gly Asn Ser Ser Ile Ser Ile His Phe Glu Asp Phe Tyr Leu Glu Ser
    2610                2615                2620
His Gln Asp Cys Gln Phe Asp Val Leu Glu Phe Arg Val Gly Asp Ala
2625                2630                2635                2640
Asp Gly Pro Leu Met Trp Arg Leu Cys Gly Pro Ser Lys Pro Thr Leu
                2645                2650                2655
Pro Leu Val Ile Pro Tyr Ser Gln Val Trp Ile His Phe Val Thr Asn
            2660                2665                2670
Glu Arg Val Glu His Ile Gly Phe His Ala Lys Tyr Ser Phe Thr Asp
        2675                2680                2685
Cys Gly Gly Ile Gln Ile Gly Asp Ser Gly Val Ile Thr Ser Pro Asn
    2690                2695                2700
Tyr Pro Asn Ala Tyr Asp Ser Leu Thr His Cys Ser Trp Leu Leu Glu
2705                2710                2715                2720
Ala Pro Gln Gly His Thr Ile Thr Leu Thr Phe Ser Asp Phe Asp Ile
                2725                2730                2735
Glu Pro His Thr Thr Cys Ala Trp Asp Ser Val Thr Val Arg Asn Gly
            2740                2745                2750
Gly Ser Pro Glu Ser Pro Ile Ile Gly Gln Tyr Cys Gly Asn Ser Asn
        2755                2760                2765
Pro Arg Thr Ile Gln Ser Gly Ser Asn Gln Leu Val Val Thr Phe Asn
    2770                2775                2780
Ser Asp His Ser Leu Gln Gly Gly Gly Phe Tyr Ala Thr Trp Asn Thr
2785                2790                2795                2800
Gln Thr Leu Gly Cys Gly Gly Ile Phe His Ser Asp Asn Gly Thr Ile
                2805                2810                2815
Arg Ser Pro His Trp Pro Gln Asn Phe Pro Glu Asn Ser Arg Cys Ser
            2820                2825                2830
Trp Thr Ala Ile Thr His Lys Ser Lys His Leu Glu Ile Ser Phe Asp
        2835                2840                2845
Asn Asn Phe Leu Ile Pro Ser Gly Asp Gly Gln Cys Gln Asn Ser Phe
    2850                2855                2860
Val Lys Val Trp Ala Gly Thr Glu Glu Val Asp Lys Ala Leu Leu Ala
2865                2870                2875                2880
Thr Gly Cys Gly Asn Val Ala Pro Gly Pro Val Ile Thr Pro Ser Asn
                2885                2890                2895
Thr Phe Thr Ala Val Phe Gln Ser Gln Glu Ala Pro Ala Gln Gly Phe
            2900                2905                2910
Ser Ala Ser Phe Val Ser Arg Cys Gly Ser Asn Phe Thr Gly Pro Ser
        2915                2920                2925
Gly Tyr Ile Ile Ser Pro Asn Tyr Pro Lys Gln Tyr Asp Asn Asn Met
    2930                2935                2940
Asn Cys Thr Tyr Val Ile Glu Ala Asn Pro Leu Ser Val Val Leu Leu
2945                2950                2955                2960
Thr Phe Val Ser Phe His Leu Glu Ala Arg Ser Ala Val Thr Gly Ser
                2965                2970                2975
Cys Val Asn Asp Gly Val His Ile Ile Arg Gly Tyr Ser Val Met Ser
            2980                2985                2990
Thr Pro Phe Ala Thr Val Cys Gly Asp Glu Met Pro Ala Pro Leu Thr
        2995                3000                3005
Ile Ala Gly Pro Val Leu Leu Asn Phe Tyr Ser Asn Glu Gln Ile Thr
    3010                3015                3020
Asp Phe Gly Phe Lys Phe Ser Tyr Arg Ile Ile Ser Cys Gly Gly Val
3025                3030                3035                3040
Phe Asn Phe Ser Ser Gly Ile Ile Thr Ser Pro Ala Tyr Ser Tyr Ala
                3045                3050                3055
Asp Tyr Pro Asn Asp Met His Cys Leu Tyr Thr Ile Thr Val Ser Asp
            3060                3065                3070
Asp Lys Val Ile Glu Leu Lys Phe Ser Asp Phe Asp Val Val Pro Ser
        3075                3080                3085
Thr Ser Cys Ser His Asp Tyr Leu Ala Ile Tyr Asp Gly Ala Asn Thr
    3090                3095                3100
Ser Asp Pro Leu Leu Gly Lys Phe Cys Gly Ser Lys Arg Pro Pro Asn
3105                3110                3115                3120
Val Lys Ser Ser Asn Asn Ser Met Leu Leu Val Phe Lys Thr Asp Ser
                3125                3130                3135
Phe Gln Thr Ala Lys Gly Trp Lys Met Ser Phe Arg Gln Thr Leu Gly
            3140                3145                3150
Pro Gln Gln Gly Cys Gly Gly Tyr Leu Thr Gly Ser Asn Asn Thr Phe
        3155                3160                3165
Ala Ser Pro Asp Ser Asp Ser Asn Gly Met Tyr Asp Lys Asn Leu Asn
    3170                3175                3180
Cys Val Trp Ile Ile Ile Ala Pro Val Asn Lys Val Ile His Leu Thr
3185                3190                3195                3200
Phe Asn Thr Phe Ala Leu Glu Ala Ala Ser Thr Arg Gln Arg Cys Leu
                3205                3210                3215
Tyr Asp Tyr Val Lys Leu Tyr Asp Gly Asp Ser Glu Asn Ala Asn Leu
            3220                3225                3230
Ala Gly Thr Phe Cys Gly Ser Thr Val Pro Ala Pro Phe Ile Ser Ser
        3235                3240                3245
Gly Asn Phe Leu Thr Val Gln Phe Ile Ser Asp Leu Thr Leu Glu Arg
    3250                3255                3260
Glu Gly Phe Asn Ala Thr Tyr Thr Ile Met Asp Met Pro Cys Gly Gly
3265                3270                3275                3280
Thr Tyr Asn Ala Thr Trp Thr Pro Gln Asn Ile Ser Ser Pro Asn Ser
                3285                3290                3295
Ser Asp Pro Asp Val Pro Phe Ser Ile Cys Thr Trp Val Ile Asp Ser
            3300                3305                3310
Pro Pro His Gln Gln Val Lys Ile Thr Val Trp Ala Leu Gln Leu Thr
        3315                3320                3325
Ser Gln Asp Cys Thr Gln Asn Tyr Leu Gln Leu Gln Asp Ser Pro Gln
    3330                3335                3340
Gly His Gly Asn Ser Arg Phe Gln Phe Cys Gly Arg Asn Ala Ser Ala
3345                3350                3355                3360
Val Pro Val Phe Tyr Ser Ser Met Ser Thr Ala Met Val Ile Phe Lys
                3365                3370                3375
Ser Gly Val Val Asn Arg Asn Ser Arg Met Ser Phe Thr Tyr Gln Ile
            3380                3385                3390
Ala Asp Cys Asn Arg Asp Tyr His Lys Ala Phe Gly Asn Leu Arg Ser
        3395                3400                3405
Pro Gly Trp Pro Asp Asn Tyr Asp Asn Asp Lys Asp Cys Thr Val Thr
    3410                3415                3420
Leu Thr Ala Pro Gln Asn His Thr Ile Ser Leu Phe Phe His Ser Leu
3425                3430                3435                3440
Gly Ile Glu Asn Ser Val Glu Cys Arg Asn Asp Phe Leu Glu Val Arg
                3445                3450                3455
Asn Gly Ser Asn Ser Asn Ser Pro Leu Leu Gly Lys Tyr Cys Gly Thr
            3460                3465                3470
Leu Leu Pro Asn Pro Val Phe Ser Gln Asn Asn Glu Leu Tyr Leu Arg
        3475                3480                3485
Phe Lys Ser Asp Ser Val Thr Ser Asp Arg Gly Tyr Glu Ile Ile Trp
    3490                3495                3500
Thr Ser Ser Pro Ser Gly Cys Gly Gly Thr Leu Tyr Gly Asp Arg Gly
3505                3510                3515                3520
Ser Phe Thr Ser Pro Gly Tyr Pro Gly Thr Tyr Pro Asn Asn Thr Tyr
                3525                3530                3535
Cys Glu Trp Val Leu Val Ala Pro Ala Gly Arg Leu Val Thr Ile Asn
            3540                3545                3550
Phe Tyr Phe Ile Ser Ile Asp Asp Pro Gly Asp Cys Val Gln Asn Tyr
        3555                3560                3565
Leu Thr Leu Tyr Asp Gly Pro Asn Ala Ser Ser Pro Ser Ser Gly Pro
    3570                3575                3580
Tyr Cys Gly Gly Asp Thr Ser Ile Ala Pro Phe Val Ala Ser Ser Asn
3585                3590                3595                3600
Gln Val Phe Ile Lys Phe His Ala Asp Tyr Ala Arg Arg Pro Ser Ala
                3605                3610                3615
Phe Arg Leu Thr Trp Asp Ser
            3620

<210> 702
<211> 3623
<212> PRT
<213> Homo sapiens

<400> 702
Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu
 1               5                  10                  15
Ile Phe Ala Glu Val Asn Gly Glu Arg Gly Glu Leu Glu Leu Gln Arg
            20                  25                  30
Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg
        35                  40                  45
Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg
    50                  55                  60
Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu
65                  70                  75                  80
Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys
                85                  90                  95
Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln
            100                 105                 110
Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln
        115                 120                 125
Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly
    130                 135                 140
Gly Asn Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro
145                 150                 155                 160
Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile
                165                 170                 175
Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn
            180                 185                 190
Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro
        195                 200                 205
Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg
    210                 215                 220
Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu
225                 230                 235                 240
Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Ser Ser Pro Asn
                245                 250                 255
Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly
            260                 265                 270
Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr
        275                 280                 285
Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu
    290                 295                 300
Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro
305                 310                 315                 320
Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys
                325                 330                 335
Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile
            340                 345                 350
Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser
        355                 360                 365
Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly
    370                 375                 380
Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu
385                 390                 395                 400
Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr
                405                 410                 415
Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn
            420                 425                 430
Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val
        435                 440                 445
Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly
    450                 455                 460
Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly
465                 470                 475                 480
Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His
                485                 490                 495
Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu
            500                 505                 510
Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro
        515                 520                 525
His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln
    530                 535                 540
Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser
545                 550                 555                 560
Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly
                565                 570                 575
Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly
            580                 585                 590
Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly
        595                 600                 605
Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro
    610                 615                 620
Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His
625                 630                 635                 640
Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr
                645                 650                 655
Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro
            660                 665                 670
Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser
        675                 680                 685
Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser
    690                 695                 700
Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe
705                 710                 715                 720
Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr
                725                 730                 735
Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His
            740                 745                 750
Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val
        755                 760                 765
Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile
    770                 775                 780
Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile
785                 790                 795                 800
Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala
                805                 810                 815
Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe
            820                 825                 830
Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln
        835                 840                 845
Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly
    850                 855                 860
Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser
865                 870                 875                 880
Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro
                885                 890                 895
Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys
            900                 905                 910
Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu
        915                 920                 925
Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln
    930                 935                 940
Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp
945                 950                 955                 960
His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr
                965                 970                 975
Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val
            980                 985                 990
Tyr Asp Thr Asp Ser Glu Thr Ser Leu Gly Arg Tyr Cys Gly Lys Ser
        995                 1000                1005
Ile Pro Pro Ser Leu Thr Ser Ser Gly Asn Ser Leu Met Leu Val Phe
    1010                1015                1020
Val Thr Asp Ser Asp Leu Ala Tyr Glu Gly Phe Leu Ile Asn Tyr Glu
1025                1030                1035                1040
Ala Ile Ser Ala Ala Thr Ala Cys Leu Gln Asp Tyr Thr Asp Asp Leu
                1045                1050                1055
Gly Thr Phe Thr Ser Pro Asn Phe Pro Asn Asn Tyr Pro Asn Asn Trp
            1060                1065                1070
Glu Cys Ile Tyr Arg Ile Thr Val Arg Thr Gly Gln Leu Ile Ala Val
        1075                1080                1085
His Phe Thr Asn Phe Ser Leu Glu Glu Ala Ile Gly Asn Tyr Tyr Thr
    1090                1095                1100
Asp Phe Leu Glu Ile Arg Asp Gly Gly Tyr Glu Lys Ser Pro Leu Leu
1105                1110                1115                1120
Gly Ile Phe Tyr Gly Ser Asn Leu Pro Pro Thr Ile Ile Ser His Ser
                1125                1130                1135
Asn Lys Leu Trp Leu Lys Phe Lys Ser Asp Gln Ile Asp Thr Arg Ser
            1140                1145                1150
Gly Phe Ser Ala Tyr Trp Asp Gly Ser Ser Thr Gly Cys Gly Gly Asn
        1155                1160                1165
Leu Thr Thr Ser Ser Gly Thr Phe Ile Ser Pro Asn Tyr Pro Met Pro
    1170                1175                1180
Tyr Tyr His Ser Ser Glu Cys Tyr Trp Trp Leu Lys Ser Ser His Gly
1185                1190                1195                1200
Ser Ala Phe Glu Leu Glu Phe Lys Asp Phe His Leu Glu His His Pro
                1205                1210                1215
Asn Cys Thr Leu Asp Tyr Leu Ala Val Tyr Asp Gly Pro Ser Ser Asn
            1220                1225                1230
Ser His Leu Leu Thr Gln Leu Cys Gly Asp Glu Lys Pro Pro Leu Ile
        1235                1240                1245
Arg Ser Ser Gly Asp Ser Met Phe Ile Lys Leu Arg Thr Asp Glu Gly
    1250                1255                1260
Gln Gln Gly Arg Gly Phe Lys Ala Glu Tyr Arg Gln Thr Cys Glu Asn
1265                1270                1275                1280
Val Val Ile Val Asn Gln Thr Tyr Gly Ile Leu Glu Ser Ile Gly Tyr
                1285                1290                1295
Pro Asn Pro Tyr Ser Glu Asn Gln His Cys Asn Trp Thr Ile Arg Ala
            1300                1305                1310
Thr Thr Gly Asn Thr Val Asn Tyr Thr Phe Leu Ala Phe Asp Leu Glu
        1315                1320                1325
His His Ile Asn Cys Ser Thr Asp Tyr Leu Glu Leu Tyr Asp Gly Pro
    1330                1335                1340
Arg Gln Met Gly Arg Tyr Cys Gly Val Asp Leu Pro Pro Pro Gly Ser
1345                1350                1355                1360
Thr Thr Ser Ser Lys Leu Gln Val Leu Leu Leu Thr Asp Gly Val Gly
                1365                1370                1375
Arg Arg Glu Lys Gly Phe Gln Met Gln Trp Phe Val Tyr Gly Cys Gly
            1380                1385                1390
Gly Glu Leu Ser Gly Ala Thr Gly Ser Phe Ser Ser Pro Gly Phe Pro
        1395                1400                1405
Asn Arg Tyr Pro Pro Asn Lys Glu Cys Ile Trp Tyr Ile Arg Thr Asp
    1410                1415                1420
Pro Gly Ser Ser Ile Gln Leu Thr Ile His Asp Phe Asp Val Glu Tyr
1425                1430                1435                1440
His Ser Arg Cys Asn Phe Asp Val Leu Glu Ile Tyr Gly Gly Pro Asp
                1445                1450                1455
Phe His Ser Pro Arg Ile Ala Gln Leu Cys Thr Gln Arg Ser Pro Glu
            1460                1465                1470
Asn Pro Met Gln Val Ser Ser Thr Gly Asn Glu Leu Ala Ile Arg Phe
        1475                1480                1485
Lys Thr Asp Leu Ser Ile Asn Gly Arg Gly Phe Asn Ala Ser Trp Gln
    1490                1495                1500
Ala Val Thr Gly Gly Cys Gly Gly Ile Phe Gln Ala Pro Ser Gly Glu
1505                1510                1515                1520
Ile His Ser Pro Asn Tyr Pro Ser Pro Tyr Arg Ser Asn Thr Asp Cys
                1525                1530                1535
Ser Trp Val Ile Arg Val Asp Arg Tyr His Arg Val Leu Leu Asn Phe
            1540                1545                1550
Thr Asp Phe Asp Leu Glu Pro Gln Asp Ser Cys Ile Met Ala Tyr Asp
        1555                1560                1565
Gly Leu Ser Ser Thr Met Ser Arg Leu Ala Arg Thr Cys Gly Arg Glu
    1570                1575                1580
Gln Leu Ala Asn Pro Ile Val Ser Ser Gly Asn Ser Leu Phe Leu Arg
1585                1590                1595                1600
Phe Gln Ser Gly Pro Ser Arg Gln Asn Arg Gly Phe Arg Ala Gln Phe
                1605                1610                1615
Arg Gln Ala Cys Gly Gly His Ile Leu Thr Ser Ser Phe Asp Thr Val
            1620                1625                1630
Ser Ser Pro Arg Phe Pro Ala Asn Tyr Pro Asn Asn Gln Asn Cys Ser
        1635                1640                1645
Trp Ile Ile Gln Ala Gln Pro Pro Leu Asn His Ile Thr Leu Ser Phe
    1650                1655                1660
Thr His Phe Glu Leu Glu Arg Ser Thr Thr Cys Ala Arg Asp Phe Val
1665                1670                1675                1680
Glu Ile Leu Asp Gly Gly His Glu Asp Ala Pro Leu Arg Gly Arg Tyr
                1685                1690                1695
Cys Gly Thr Asp Met Pro His Pro Ile Thr Ser Phe Ser Ser Ala Leu
            1700                1705                1710
Thr Leu Arg Phe Val Ser Asp Ser Ser Ile Ser Ala Gly Gly Phe His
        1715                1720                1725
Thr Thr Val Thr Ala Ser Val Ser Ala Cys Gly Gly Thr Phe Tyr Met
    1730                1735                1740
Ala Glu Gly Ile Phe Asn Ser Pro Gly Tyr Pro Asp Ile Tyr Pro Pro
1745                1750                1755                1760
Asn Val Glu Cys Val Trp Asn Ile Ile Ser Ser Pro Gly Asn Arg Leu
                1765                1770                1775
Gln Leu Ser Phe Ile Ser Phe Gln Leu Glu Asp Ser Gln Asp Cys Ser
            1780                1785                1790
Arg Asp Phe Val Glu Ile Arg Glu Gly Asn Ala Thr Gly His Leu Val
        1795                1800                1805
Gly Arg Tyr Cys Gly Asn Ser Phe Pro Leu Asn Tyr Ser Ser Ile Val
    1810                1815                1820
Gly His Thr Leu Trp Val Arg Phe Ile Ser Asp Gly Ser Gly Ser Gly
1825                1830                1835                1840
Thr Gly Phe Gln Ala Thr Phe Met Lys Ile Phe Gly Asn Asp Asn Ile
                1845                1850                1855
Val Gly Thr His Gly Lys Val Ala Ser Pro Phe Trp Pro Glu Asn Tyr
            1860                1865                1870
Pro His Asn Ser Asn Tyr Gln Trp Thr Val Asn Val Asn Ala Ser His
        1875                1880                1885
Val Val His Gly Arg Ile Leu Glu Met Asp Ile Glu Glu Ile Gln Asn
    1890                1895                1900
Cys Tyr Tyr Asp Lys Leu Arg Ile Tyr Asp Gly Pro Ser Ile His Ala
1905                1910                1915                1920
Arg Leu Ile Gly Ala Tyr Cys Gly Thr Gln Thr Glu Ser Phe Ser Ser
                1925                1930                1935
Thr Gly Asn Ser Leu Thr Phe His Phe Tyr Ser Asp Ser Ser Ile Ser
            1940                1945                1950
Gly Lys Gly Phe Leu Leu Glu Trp Phe Ala Val Asp Ala Pro Asp Gly
        1955                1960                1965
Val Leu Pro Thr Ile Ala Pro Gly Ala Cys Gly Gly Phe Leu Arg Thr
    1970                1975                1980
Gly Asp Ala Pro Val Phe Leu Phe Ser Pro Gly Trp Pro Asp Ser Tyr
1985                1990                1995                2000
Ser Asn Arg Val Asp Cys Thr Trp Leu Ile Gln Ala Pro Asp Ser Thr
                2005                2010                2015
Val Glu Leu Asn Ile Leu Ser Leu Asp Ile Glu Ser His Arg Thr Cys
            2020                2025                2030
Ala Tyr Asp Ser Leu Val Ile Arg Asp Gly Asp Asn Asn Leu Ala Gln
        2035                2040                2045
Gln Leu Ala Val Leu Cys Gly Arg Glu Ile Pro Gly Pro Ile Arg Ser
    2050                2055                2060
Thr Gly Glu Tyr Met Phe Ile Arg Phe Thr Ser Asp Ser Ser Val Thr
2065                2070                2075                2080
Arg Ala Gly Phe Asn Ala Ser Phe His Lys Ser Cys Gly Gly Tyr Leu
                2085                2090                2095
His Ala Asp Arg Gly Ile Ile Thr Ser Pro Lys Tyr Pro Glu Thr Tyr
            2100                2105                2110
Pro Ser Asn Leu Asn Cys Ser Trp His Val Leu Val Gln Ser Gly Leu
        2115                2120                2125
Thr Ile Ala Val His Phe Glu Gln Pro Phe Gln Ile Pro Asn Gly Asp
    2130                2135                2140
Ser Ser Cys Asn Gln Gly Asp Tyr Leu Val Leu Arg Asn Gly Pro Asp
2145                2150                2155                2160
Ile Tyr Ser Pro Pro Leu Gly Pro Pro Gly Gly Asn Gly His Phe Cys
                2165                2170                2175
Gly Ser His Ala Ser Ser Thr Leu Phe Thr Ser Asp Asn Gln Met Phe
            2180                2185                2190
Val Gln Phe Ile Ser Asp His Ser Asn Glu Gly Gln Gly Phe Lys Ile
        2195                2200                2205
Lys Tyr Glu Ala Lys Ser Leu Ala Cys Gly Gly Asn Val Tyr Ile His
    2210                2215                2220
Asp Ala Asp Ser Ala Gly Tyr Val Thr Ser Pro Asn His Pro His Asn
2225                2230                2235                2240
Tyr Pro Pro His Ala Asp Cys Ile Trp Ile Leu Ala Ala Pro Pro Glu
                2245                2250                2255
Thr Arg Ile Gln Leu Gln Phe Glu Asp Arg Phe Asp Ile Glu Val Thr
            2260                2265                2270
Pro Asn Cys Thr Ser Asn Tyr Leu Glu Leu Arg Asp Gly Val Asp Ser
        2275                2280                2285
Asp Ala Pro Ile Leu Ser Lys Phe Cys Gly Thr Ser Leu Pro Ser Ser
    2290                2295                2300
Gln Trp Ser Ser Gly Glu Val Met Tyr Leu Arg Phe Arg Ser Asp Asn
2305                2310                2315                2320
Ser Pro Thr His Val Gly Phe Lys Ala Lys Tyr Ser Ile Ala Gln Cys
                2325                2330                2335
Gly Gly Arg Val Pro Gly Gln Ser Gly Val Val Glu Ser Ile Gly His
            2340                2345                2350
Pro Thr Leu Pro Tyr Arg Asp Asn Leu Phe Cys Glu Trp His Leu Gln
        2355                2360                2365
Gly Leu Ser Gly His Tyr Leu Thr Ile Ser Phe Glu Asp Phe Asn Leu
    2370                2375                2380
Gln Asn Ser Ser Gly Cys Glu Lys Asp Phe Val Glu Ile Trp Asp Asn
2385                2390                2395                2400
His Thr Ser Gly Asn Ile Leu Gly Arg Tyr Cys Gly Asn Thr Ile Pro
                2405                2410                2415
Asp Ser Ile Asp Thr Ser Ser Asn Thr Ala Val Val Arg Phe Val Thr
            2420                2425                2430
Asp Gly Ser Val Thr Ala Ser Gly Phe Arg Leu Arg Phe Glu Ser Ser
        2435                2440                2445
Met Glu Glu Cys Gly Gly Asp Leu Gln Gly Ser Ile Gly Thr Phe Thr
    2450                2455                2460
Ser Pro Asn Tyr Pro Asn Pro Asn Pro His Gly Arg Ile Cys Glu Trp
2465                2470                2475                2480
Arg Ile Thr Ala Pro Glu Gly Arg Arg Ile Thr Leu Met Phe Asn Asn
                2485                2490                2495
Leu Arg Leu Ala Thr His Pro Ser Cys Asn Asn Glu His Val Ile Val
            2500                2505                2510
Phe Asn Gly Ile Arg Ser Asn Ser Pro Gln Leu Glu Lys Leu Cys Ser
        2515                2520                2525
Ser Val Asn Val Ser Asn Glu Ile Lys Ser Ser Gly Asn Thr Met Lys
    2530                2535                2540
Val Ile Phe Phe Thr Asp Gly Ser Arg Pro Tyr Gly Gly Phe Thr Ala
2545                2550                2555                2560
Ser Tyr Thr Ser Ser Glu Asp Ala Val Cys Gly Gly Ser Leu Pro Asn
                2565                2570                2575
Thr Pro Glu Gly Asn Phe Thr Ser Pro Gly Tyr Asp Gly Val Arg Asn
            2580                2585                2590
Tyr Ser Arg Asn Leu Asn Cys Glu Trp Thr Leu Ser Asn Pro Asn Gln
        2595                2600                2605
Gly Asn Ser Ser Ile Ser Ile His Phe Glu Asp Phe Tyr Leu Glu Ser
    2610                2615                2620
His Gln Asp Cys Gln Phe Asp Val Leu Glu Phe Arg Val Gly Asp Ala
2625                2630                2635                2640
Asp Gly Pro Leu Met Trp Arg Leu Cys Gly Pro Ser Lys Pro Thr Leu
                2645                2650                2655
Pro Leu Val Ile Pro Tyr Ser Gln Val Trp Ile His Phe Val Thr Asn
            2660                2665                2670
Glu Arg Val Glu His Ile Gly Phe His Ala Lys Tyr Ser Phe Thr Asp
        2675                2680                2685
Cys Gly Gly Ile Gln Ile Gly Asp Ser Gly Val Ile Thr Ser Pro Asn
    2690                2695                2700
Tyr Pro Asn Ala Tyr Asp Ser Leu Thr His Cys Ser Trp Leu Leu Glu
2705                2710                2715                2720
Ala Pro Gln Gly His Thr Ile Thr Leu Thr Phe Ser Asp Phe Asp Ile
                2725                2730                2735
Glu Pro His Thr Thr Cys Ala Trp Asp Ser Val Thr Val Arg Asn Gly
            2740                2745                2750
Gly Ser Pro Glu Ser Pro Ile Ile Gly Gln Tyr Cys Gly Asn Ser Asn
        2755                2760                2765
Pro Arg Thr Ile Gln Ser Gly Ser Asn Gln Leu Val Val Thr Phe Asn
    2770                2775                2780
Ser Asp His Ser Leu Gln Gly Gly Gly Phe Tyr Ala Thr Trp Asn Thr
2785                2790                2795                2800
Gln Thr Leu Gly Cys Gly Gly Ile Phe His Ser Asp Asn Gly Thr Ile
                2805                2810                2815
Arg Ser Pro His Trp Pro Gln Asn Phe Pro Glu Asn Ser Arg Cys Ser
            2820                2825                2830
Trp Thr Ala Ile Thr His Lys Ser Lys His Leu Glu Ile Ser Phe Asp
        2835                2840                2845
Asn Asn Phe Leu Ile Pro Ser Gly Asp Gly Gln Cys Gln Asn Ser Phe
    2850                2855                2860
Val Lys Val Trp Ala Gly Thr Glu Glu Val Asp Lys Ala Leu Leu Ala
2865                2870                2875                2880
Thr Gly Cys Gly Asn Val Ala Pro Gly Pro Val Ile Thr Pro Ser Asn
                2885                2890                2895
Thr Phe Thr Ala Val Phe Gln Ser Gln Glu Ala Pro Ala Gln Gly Phe
            2900                2905                2910
Ser Ala Ser Phe Val Ser Arg Cys Gly Ser Asn Phe Thr Gly Pro Ser
        2915                2920                2925
Gly Tyr Ile Ile Ser Pro Asn Tyr Pro Lys Gln Tyr Asp Asn Asn Met
    2930                2935                2940
Asn Cys Thr Tyr Val Ile Glu Ala Asn Pro Leu Ser Val Val Leu Leu
2945                2950                2955                2960
Thr Phe Val Ser Phe His Leu Glu Ala Arg Ser Ala Val Thr Gly Ser
                2965                2970                2975
Cys Val Asn Asp Gly Val His Ile Ile Arg Gly Tyr Ser Val Met Ser
            2980                2985                2990
Thr Pro Phe Ala Thr Val Cys Gly Asp Glu Met Pro Ala Pro Leu Thr
        2995                3000                3005
Ile Ala Gly Pro Val Leu Leu Asn Phe Tyr Ser Asn Glu Gln Ile Thr
    3010                3015                3020
Asp Phe Gly Phe Lys Phe Ser Tyr Arg Ile Ile Ser Cys Gly Gly Val
3025                3030                3035                3040
Phe Asn Phe Ser Ser Gly Ile Ile Thr Ser Pro Ala Tyr Ser Tyr Ala
                3045                3050                3055
Asp Tyr Pro Asn Asp Met His Cys Leu Tyr Thr Ile Thr Val Ser Asp
            3060                3065                3070
Asp Lys Val Ile Glu Leu Lys Phe Ser Asp Phe Asp Val Val Pro Ser
        3075                3080                3085
Thr Ser Cys Ser His Asp Tyr Leu Ala Ile Tyr Asp Gly Ala Asn Thr
    3090                3095                3100
Ser Asp Pro Leu Leu Gly Lys Phe Cys Gly Ser Lys Arg Pro Pro Asn
3105                3110                3115                3120
Val Lys Ser Ser Asn Asn Ser Met Leu Leu Val Phe Lys Thr Asp Ser
                3125                3130                3135
Phe Gln Thr Ala Lys Gly Trp Lys Met Ser Phe Arg Gln Thr Leu Gly
            3140                3145                3150
Pro Gln Gln Gly Cys Gly Gly Tyr Leu Thr Gly Ser Asn Asn Thr Phe
        3155                3160                3165
Ala Ser Pro Asp Ser Asp Ser Asn Gly Met Tyr Asp Lys Asn Leu Asn
    3170                3175                3180
Cys Val Trp Ile Ile Ile Ala Pro Val Asn Lys Val Ile His Leu Thr
3185                3190                3195                3200
Phe Asn Thr Phe Ala Leu Glu Ala Ala Ser Thr Arg Gln Arg Cys Leu
                3205                3210                3215
Tyr Asp Tyr Val Lys Leu Tyr Asp Gly Asp Ser Glu Asn Ala Asn Leu
            3220                3225                3230
Ala Gly Thr Phe Cys Gly Ser Thr Val Pro Ala Pro Phe Ile Ser Ser
        3235                3240                3245
Gly Asn Phe Leu Thr Val Gln Phe Ile Ser Asp Leu Thr Leu Glu Arg
    3250                3255                3260
Glu Gly Phe Asn Ala Thr Tyr Thr Ile Met Asp Met Pro Cys Gly Gly
3265                3270                3275                3280
Thr Tyr Asn Ala Thr Trp Thr Pro Gln Asn Ile Ser Ser Pro Asn Ser
                3285                3290                3295
Ser Asp Pro Asp Val Pro Phe Ser Ile Cys Thr Trp Val Ile Asp Ser
            3300                3305                3310
Pro Pro His Gln Gln Val Lys Ile Thr Val Trp Ala Leu Gln Leu Thr
        3315                3320                3325
Ser Gln Asp Cys Thr Gln Asn Tyr Leu Gln Leu Gln Asp Ser Pro Gln
    3330                3335                3340
Gly His Gly Asn Ser Arg Phe Gln Phe Cys Gly Arg Asn Ala Ser Ala
3345                3350                3355                3360
Val Pro Val Phe Tyr Ser Ser Met Ser Thr Ala Met Val Ile Phe Lys
                3365                3370                3375
Ser Gly Val Val Asn Arg Asn Ser Arg Met Ser Phe Thr Tyr Gln Ile
            3380                3385                3390
Ala Asp Cys Asn Arg Asp Tyr His Lys Ala Phe Gly Asn Leu Arg Ser
        3395                3400                3405
Pro Gly Trp Pro Asp Asn Tyr Asp Asn Asp Lys Asp Cys Thr Val Thr
    3410                3415                3420
Leu Thr Ala Pro Gln Asn His Thr Ile Ser Leu Phe Phe His Ser Leu
3425                3430                3435                3440
Gly Ile Glu Asn Ser Val Glu Cys Arg Asn Asp Phe Leu Glu Val Arg
                3445                3450                3455
Asn Gly Ser Asn Ser Asn Ser Pro Leu Leu Gly Lys Tyr Cys Gly Thr
            3460                3465                3470
Leu Leu Pro Asn Pro Val Phe Ser Gln Asn Asn Glu Leu Tyr Leu Arg
        3475                3480                3485
Phe Lys Ser Asp Ser Val Thr Ser Asp Arg Gly Tyr Glu Ile Ile Trp
    3490                3495                3500
Thr Ser Ser Pro Ser Gly Cys Gly Gly Thr Leu Tyr Gly Asp Arg Gly
3505                3510                3515                3520
Ser Phe Thr Ser Pro Gly Tyr Pro Gly Thr Tyr Pro Asn Asn Thr Tyr
                3525                3530                3535
Cys Glu Trp Val Leu Val Ala Pro Ala Gly Arg Leu Val Thr Ile Asn
            3540                3545                3550
Phe Tyr Phe Ile Ser Ile Asp Asp Pro Gly Asp Cys Val Gln Asn Tyr
        3555                3560                3565
Leu Thr Leu Tyr Asp Gly Pro Asn Ala Ser Ser Pro Ser Ser Gly Pro
    3570                3575                3580
Tyr Cys Gly Gly Asp Thr Ser Ile Ala Pro Phe Val Ala Ser Ser Asn
3585                3590                3595                3600
Gln Val Phe Ile Lys Phe His Ala Asp Tyr Ala Arg Arg Pro Ser Ala
                3605                3610                3615
Phe Arg Leu Thr Trp Asp Ser
            3620

<210> 703
<211> 3494
<212> PRT
<213> Homo sapiens

<400> 703
Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly
 1               5                  10                  15
Asn Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro Gln
            20                  25                  30
Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile Tyr
        35                  40                  45
Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn Thr
    50                  55                  60
Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro Gln
65                  70                  75                  80
Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg Cys
                85                  90                  95
Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu Pro
            100                 105                 110
Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Ser Ser Pro Asn Ser
        115                 120                 125
Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly Pro
    130                 135                 140
Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr Cys
145                 150                 155                 160
Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu Asp
                165                 170                 175
Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro Pro
            180                 185                 190
Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys Pro
        195                 200                 205
Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile Cys
    210                 215                 220
Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser Thr
225                 230                 235                 240
Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly Asn
                245                 250                 255
Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu Ser
            260                 265                 270
His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr Phe
        275                 280                 285
Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn Ile
    290                 295                 300
Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val Asp
305                 310                 315                 320
Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly Ala
                325                 330                 335
Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly Ile
            340                 345                 350
Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His Asp
        355                 360                 365
Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu Arg
    370                 375                 380
Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro His
385                 390                 395                 400
Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln Leu
                405                 410                 415
Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser Asp
            420                 425                 430
Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly Arg
        435                 440                 445
Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly Ile
    450                 455                 460
Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly Asn
465                 470                 475                 480
Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro Asp
                485                 490                 495
Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His Asp
            500                 505                 510
Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr Gln
        515                 520                 525
Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro Leu
    530                 535                 540
Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser Gln
545                 550                 555                 560
Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser Asp
                565                 570                 575
Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe Leu
            580                 585                 590
Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr Met
        595                 600                 605
Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His Val
    610                 615                 620
Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val Arg
625                 630                 635                 640
Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile Ser
                645                 650                 655
His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile Asp
            660                 665                 670
Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala Cys
        675                 680                 685
Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe Pro
    690                 695                 700
Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln Pro
705                 710                 715                 720
Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly Ser
                725                 730                 735
Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser Ile
            740                 745                 750
Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro Ser
        755                 760                 765
Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys Ser
    770                 775                 780
Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu Asp
785                 790                 795                 800
Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln Ser
                805                 810                 815
Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp His
            820                 825                 830
Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr Phe
        835                 840                 845
His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val Tyr
    850                 855                 860
Asp Thr Asp Ser Glu Thr Ser Leu Gly Arg Tyr Cys Gly Lys Ser Ile
865                 870                 875                 880
Pro Pro Ser Leu Thr Ser Ser Gly Asn Ser Leu Met Leu Val Phe Val
                885                 890                 895
Thr Asp Ser Asp Leu Ala Tyr Glu Gly Phe Leu Ile Asn Tyr Glu Ala
            900                 905                 910
Ile Ser Ala Ala Thr Ala Cys Leu Gln Asp Tyr Thr Asp Asp Leu Gly
        915                 920                 925
Thr Phe Thr Ser Pro Asn Phe Pro Asn Asn Tyr Pro Asn Asn Trp Glu
    930                 935                 940
Cys Ile Tyr Arg Ile Thr Val Arg Thr Gly Gln Leu Ile Ala Val His
945                 950                 955                 960
Phe Thr Asn Phe Ser Leu Glu Glu Ala Ile Gly Asn Tyr Tyr Thr Asp
                965                 970                 975
Phe Leu Glu Ile Arg Asp Gly Gly Tyr Glu Lys Ser Pro Leu Leu Gly
            980                 985                 990
Ile Phe Tyr Gly Ser Asn Leu Pro Pro Thr Ile Ile Ser His Ser Asn
        995                 1000                1005
Lys Leu Trp Leu Lys Phe Lys Ser Asp Gln Ile Asp Thr Arg Ser Gly
    1010                1015                1020
Phe Ser Ala Tyr Trp Asp Gly Ser Ser Thr Gly Cys Gly Gly Asn Leu
1025                1030                1035                1040
Thr Thr Ser Ser Gly Thr Phe Ile Ser Pro Asn Tyr Pro Met Pro Tyr
                1045                1050                1055
Tyr His Ser Ser Glu Cys Tyr Trp Trp Leu Lys Ser Ser His Gly Ser
            1060                1065                1070
Ala Phe Glu Leu Glu Phe Lys Asp Phe His Leu Glu His His Pro Asn
        1075                1080                1085
Cys Thr Leu Asp Tyr Leu Ala Val Tyr Asp Gly Pro Ser Ser Asn Ser
    1090                1095                1100
His Leu Leu Thr Gln Leu Cys Gly Asp Glu Lys Pro Pro Leu Ile Arg
1105                1110                1115                1120
Ser Ser Gly Asp Ser Met Phe Ile Lys Leu Arg Thr Asp Glu Gly Gln
                1125                1130                1135
Gln Gly Arg Gly Phe Lys Ala Glu Tyr Arg Gln Thr Cys Glu Asn Val
            1140                1145                1150
Val Ile Val Asn Gln Thr Tyr Gly Ile Leu Glu Ser Ile Gly Tyr Pro
        1155                1160                1165
Asn Pro Tyr Ser Glu Asn Gln His Cys Asn Trp Thr Ile Arg Ala Thr
    1170                1175                1180
Thr Gly Asn Thr Val Asn Tyr Thr Phe Leu Ala Phe Asp Leu Glu His
1185                1190                1195                1200
His Ile Asn Cys Ser Thr Asp Tyr Leu Glu Leu Tyr Asp Gly Pro Arg
                1205                1210                1215
Gln Met Gly Arg Tyr Cys Gly Val Asp Leu Pro Pro Pro Gly Ser Thr
            1220                1225                1230
Thr Ser Ser Lys Leu Gln Val Leu Leu Leu Thr Asp Gly Val Gly Arg
        1235                1240                1245
Arg Glu Lys Gly Phe Gln Met Gln Trp Phe Val Tyr Gly Cys Gly Gly
    1250                1255                1260
Glu Leu Ser Gly Ala Thr Gly Ser Phe Ser Ser Pro Gly Phe Pro Asn
1265                1270                1275                1280
Arg Tyr Pro Pro Asn Lys Glu Cys Ile Trp Tyr Ile Arg Thr Asp Pro
                1285                1290                1295
Gly Ser Ser Ile Gln Leu Thr Ile His Asp Phe Asp Val Glu Tyr His
            1300                1305                1310
Ser Arg Cys Asn Phe Asp Val Leu Glu Ile Tyr Gly Gly Pro Asp Phe
        1315                1320                1325
His Ser Pro Arg Ile Ala Gln Leu Cys Thr Gln Arg Ser Pro Glu Asn
    1330                1335                1340
Pro Met Gln Val Ser Ser Thr Gly Asn Glu Leu Ala Ile Arg Phe Lys
1345                1350                1355                1360
Thr Asp Leu Ser Ile Asn Gly Arg Gly Phe Asn Ala Ser Trp Gln Ala
                1365                1370                1375
Val Thr Gly Gly Cys Gly Gly Ile Phe Gln Ala Pro Ser Gly Glu Ile
            1380                1385                1390
His Ser Pro Asn Tyr Pro Ser Pro Tyr Arg Ser Asn Thr Asp Cys Ser
        1395                1400                1405
Trp Val Ile Arg Val Asp Arg Tyr His Arg Val Leu Leu Asn Phe Thr
    1410                1415                1420
Asp Phe Asp Leu Glu Pro Gln Asp Ser Cys Ile Met Ala Tyr Asp Gly
1425                1430                1435                1440
Leu Ser Ser Thr Met Ser Arg Leu Ala Arg Thr Cys Gly Arg Glu Gln
                1445                1450                1455
Leu Ala Asn Pro Ile Val Ser Ser Gly Asn Ser Leu Phe Leu Arg Phe
            1460                1465                1470
Gln Ser Gly Pro Ser Arg Gln Asn Arg Gly Phe Arg Ala Gln Phe Arg
        1475                1480                1485
Gln Ala Cys Gly Gly His Ile Leu Thr Ser Ser Phe Asp Thr Val Ser
    1490                1495                1500
Ser Pro Arg Phe Pro Ala Asn Tyr Pro Asn Asn Gln Asn Cys Ser Trp
1505                1510                1515                1520
Ile Ile Gln Ala Gln Pro Pro Leu Asn His Ile Thr Leu Ser Phe Thr
                1525                1530                1535
His Phe Glu Leu Glu Arg Ser Thr Thr Cys Ala Arg Asp Phe Val Glu
            1540                1545                1550
Ile Leu Asp Gly Gly His Glu Asp Ala Pro Leu Arg Gly Arg Tyr Cys
        1555                1560                1565
Gly Thr Asp Met Pro His Pro Ile Thr Ser Phe Ser Ser Ala Leu Thr
    1570                1575                1580
Leu Arg Phe Val Ser Asp Ser Ser Ile Ser Ala Gly Gly Phe His Thr
1585                1590                1595                1600
Thr Val Thr Ala Ser Val Ser Ala Cys Gly Gly Thr Phe Tyr Met Ala
                1605                1610                1615
Glu Gly Ile Phe Asn Ser Pro Gly Tyr Pro Asp Ile Tyr Pro Pro Asn
            1620                1625                1630
Val Glu Cys Val Trp Asn Ile Ile Ser Ser Pro Gly Asn Arg Leu Gln
        1635                1640                1645
Leu Ser Phe Ile Ser Phe Gln Leu Glu Asp Ser Gln Asp Cys Ser Arg
    1650                1655                1660
Asp Phe Val Glu Ile Arg Glu Gly Asn Ala Thr Gly His Leu Val Gly
1665                1670                1675                1680
Arg Tyr Cys Gly Asn Ser Phe Pro Leu Asn Tyr Ser Ser Ile Val Gly
                1685                1690                1695
His Thr Leu Trp Val Arg Phe Ile Ser Asp Gly Ser Gly Ser Gly Thr
            1700                1705                1710
Gly Phe Gln Ala Thr Phe Met Lys Ile Phe Gly Asn Asp Asn Ile Val
        1715                1720                1725
Gly Thr His Gly Lys Val Ala Ser Pro Phe Trp Pro Glu Asn Tyr Pro
    1730                1735                1740
His Asn Ser Asn Tyr Gln Trp Thr Val Asn Val Asn Ala Ser His Val
1745                1750                1755                1760
Val His Gly Arg Ile Leu Glu Met Asp Ile Glu Glu Ile Gln Asn Cys
                1765                1770                1775
Tyr Tyr Asp Lys Leu Arg Ile Tyr Asp Gly Pro Ser Ile His Ala Arg
            1780                1785                1790
Leu Ile Gly Ala Tyr Cys Gly Thr Gln Thr Glu Ser Phe Ser Ser Thr
        1795                1800                1805
Gly Asn Ser Leu Thr Phe His Phe Tyr Ser Asp Ser Ser Ile Ser Gly
    1810                1815                1820
Lys Gly Phe Leu Leu Glu Trp Phe Ala Val Asp Ala Pro Asp Gly Val
1825                1830                1835                1840
Leu Pro Thr Ile Ala Pro Gly Ala Cys Gly Gly Phe Leu Arg Thr Gly
                1845                1850                1855
Asp Ala Pro Val Phe Leu Phe Ser Pro Gly Trp Pro Asp Ser Tyr Ser
            1860                1865                1870
Asn Arg Val Asp Cys Thr Trp Leu Ile Gln Ala Pro Asp Ser Thr Val
        1875                1880                1885
Glu Leu Asn Ile Leu Ser Leu Asp Ile Glu Ser His Arg Thr Cys Ala
    1890                1895                1900
Tyr Asp Ser Leu Val Ile Arg Asp Gly Asp Asn Asn Leu Ala Gln Gln
1905                1910                1915                1920
Leu Ala Val Leu Cys Gly Arg Glu Ile Pro Gly Pro Ile Arg Ser Thr
                1925                1930                1935
Gly Glu Tyr Met Phe Ile Arg Phe Thr Ser Asp Ser Ser Val Thr Arg
            1940                1945                1950
Ala Gly Phe Asn Ala Ser Phe His Lys Ser Cys Gly Gly Tyr Leu His
        1955                1960                1965
Ala Asp Arg Gly Ile Ile Thr Ser Pro Lys Tyr Pro Glu Thr Tyr Pro
    1970                1975                1980
Ser Asn Leu Asn Cys Ser Trp His Val Leu Val Gln Ser Gly Leu Thr
1985                1990                1995                2000
Ile Ala Val His Phe Glu Gln Pro Phe Gln Ile Pro Asn Gly Asp Ser
                2005                2010                2015
Ser Cys Asn Gln Gly Asp Tyr Leu Val Leu Arg Asn Gly Pro Asp Ile
            2020                2025                2030
Tyr Ser Pro Pro Leu Gly Pro Pro Gly Gly Asn Gly His Phe Cys Gly
        2035                2040                2045
Ser His Ala Ser Ser Thr Leu Phe Thr Ser Asp Asn Gln Met Phe Val
    2050                2055                2060
Gln Phe Ile Ser Asp His Ser Asn Glu Gly Gln Gly Phe Lys Ile Lys
2065                2070                2075                2080
Tyr Glu Ala Lys Ser Leu Ala Cys Gly Gly Asn Val Tyr Ile His Asp
                2085                2090                2095
Ala Asp Ser Ala Gly Tyr Val Thr Ser Pro Asn His Pro His Asn Tyr
            2100                2105                2110
Pro Pro His Ala Asp Cys Ile Trp Ile Leu Ala Ala Pro Pro Glu Thr
        2115                2120                2125
Arg Ile Gln Leu Gln Phe Glu Asp Arg Phe Asp Ile Glu Val Thr Pro
    2130                2135                2140
Asn Cys Thr Ser Asn Tyr Leu Glu Leu Arg Asp Gly Val Asp Ser Asp
2145                2150                2155                2160
Ala Pro Ile Leu Ser Lys Phe Cys Gly Thr Ser Leu Pro Ser Ser Gln
                2165                2170                2175
Trp Ser Ser Gly Glu Val Met Tyr Leu Arg Phe Arg Ser Asp Asn Ser
            2180                2185                2190
Pro Thr His Val Gly Phe Lys Ala Lys Tyr Ser Ile Ala Gln Cys Gly
        2195                2200                2205
Gly Arg Val Pro Gly Gln Ser Gly Val Val Glu Ser Ile Gly His Pro
    2210                2215                2220
Thr Leu Pro Tyr Arg Asp Asn Leu Phe Cys Glu Trp His Leu Gln Gly
2225                2230                2235                2240
Leu Ser Gly His Tyr Leu Thr Ile Ser Phe Glu Asp Phe Asn Leu Gln
                2245                2250                2255
Asn Ser Ser Gly Cys Glu Lys Asp Phe Val Glu Ile Trp Asp Asn His
            2260                2265                2270
Thr Ser Gly Asn Ile Leu Gly Arg Tyr Cys Gly Asn Thr Ile Pro Asp
        2275                2280                2285
Ser Ile Asp Thr Ser Ser Asn Thr Ala Val Val Arg Phe Val Thr Asp
    2290                2295                2300
Gly Ser Val Thr Ala Ser Gly Phe Arg Leu Arg Phe Glu Ser Ser Met
2305                2310                2315                2320
Glu Glu Cys Gly Gly Asp Leu Gln Gly Ser Ile Gly Thr Phe Thr Ser
                2325                2330                2335
Pro Asn Tyr Pro Asn Pro Asn Pro His Gly Arg Ile Cys Glu Trp Arg
            2340                2345                2350
Ile Thr Ala Pro Glu Gly Arg Arg Ile Thr Leu Met Phe Asn Asn Leu
        2355                2360                2365
Arg Leu Ala Thr His Pro Ser Cys Asn Asn Glu His Val Ile Val Phe
    2370                2375                2380
Asn Gly Ile Arg Ser Asn Ser Pro Gln Leu Glu Lys Leu Cys Ser Ser
2385                2390                2395                2400
Val Asn Val Ser Asn Glu Ile Lys Ser Ser Gly Asn Thr Met Lys Val
                2405                2410                2415
Ile Phe Phe Thr Asp Gly Ser Arg Pro Tyr Gly Gly Phe Thr Ala Ser
            2420                2425                2430
Tyr Thr Ser Ser Glu Asp Ala Val Cys Gly Gly Ser Leu Pro Asn Thr
        2435                2440                2445
Pro Glu Gly Asn Phe Thr Ser Pro Gly Tyr Asp Gly Val Arg Asn Tyr
    2450                2455                2460
Ser Arg Asn Leu Asn Cys Glu Trp Thr Leu Ser Asn Pro Asn Gln Gly
2465                2470                2475                2480
Asn Ser Ser Ile Ser Ile His Phe Glu Asp Phe Tyr Leu Glu Ser His
                2485                2490                2495
Gln Asp Cys Gln Phe Asp Val Leu Glu Phe Arg Val Gly Asp Ala Asp
            2500                2505                2510
Gly Pro Leu Met Trp Arg Leu Cys Gly Pro Ser Lys Pro Thr Leu Pro
        2515                2520                2525
Leu Val Ile Pro Tyr Ser Gln Val Trp Ile His Phe Val Thr Asn Glu
    2530                2535                2540
Arg Val Glu His Ile Gly Phe His Ala Lys Tyr Ser Phe Thr Asp Cys
2545                2550                2555                2560
Gly Gly Ile Gln Ile Gly Asp Ser Gly Val Ile Thr Ser Pro Asn Tyr
                2565                2570                2575
Pro Asn Ala Tyr Asp Ser Leu Thr His Cys Ser Trp Leu Leu Glu Ala
            2580                2585                2590
Pro Gln Gly His Thr Ile Thr Leu Thr Phe Ser Asp Phe Asp Ile Glu
        2595                2600                2605
Pro His Thr Thr Cys Ala Trp Asp Ser Val Thr Val Arg Asn Gly Gly
    2610                2615                2620
Ser Pro Glu Ser Pro Ile Ile Gly Gln Tyr Cys Gly Asn Ser Asn Pro
2625                2630                2635                2640
Arg Thr Ile Gln Ser Gly Ser Asn Gln Leu Val Val Thr Phe Asn Ser
                2645                2650                2655
Asp His Ser Leu Gln Gly Gly Gly Phe Tyr Ala Thr Trp Asn Thr Gln
            2660                2665                2670
Thr Leu Gly Cys Gly Gly Ile Phe His Ser Asp Asn Gly Thr Ile Arg
        2675                2680                2685
Ser Pro His Trp Pro Gln Asn Phe Pro Glu Asn Ser Arg Cys Ser Trp
    2690                2695                2700
Thr Ala Ile Thr His Lys Ser Lys His Leu Glu Ile Ser Phe Asp Asn
2705                2710                2715                2720
Asn Phe Leu Ile Pro Ser Gly Asp Gly Gln Cys Gln Asn Ser Phe Val
                2725                2730                2735
Lys Val Trp Ala Gly Thr Glu Glu Val Asp Lys Ala Leu Leu Ala Thr
            2740                2745                2750
Gly Cys Gly Asn Val Ala Pro Gly Pro Val Ile Thr Pro Ser Asn Thr
        2755                2760                2765
Phe Thr Ala Val Phe Gln Ser Gln Glu Ala Pro Ala Gln Gly Phe Ser
    2770                2775                2780
Ala Ser Phe Val Ser Arg Cys Gly Ser Asn Phe Thr Gly Pro Ser Gly
2785                2790                2795                2800
Tyr Ile Ile Ser Pro Asn Tyr Pro Lys Gln Tyr Asp Asn Asn Met Asn
                2805                2810                2815
Cys Thr Tyr Val Ile Glu Ala Asn Pro Leu Ser Val Val Leu Leu Thr
            2820                2825                2830
Phe Val Ser Phe His Leu Glu Ala Arg Ser Ala Val Thr Gly Ser Cys
        2835                2840                2845
Val Asn Asp Gly Val His Ile Ile Arg Gly Tyr Ser Val Met Ser Thr
    2850                2855                2860
Pro Phe Ala Thr Val Cys Gly Asp Glu Met Pro Ala Pro Leu Thr Ile
2865                2870                2875                2880
Ala Gly Pro Val Leu Leu Asn Phe Tyr Ser Asn Glu Gln Ile Thr Asp
                2885                2890                2895
Phe Gly Phe Lys Phe Ser Tyr Arg Ile Ile Ser Cys Gly Gly Val Phe
            2900                2905                2910
Asn Phe Ser Ser Gly Ile Ile Thr Ser Pro Ala Tyr Ser Tyr Ala Asp
        2915                2920                2925
Tyr Pro Asn Asp Met His Cys Leu Tyr Thr Ile Thr Val Ser Asp Asp
    2930                2935                2940
Lys Val Ile Glu Leu Lys Phe Ser Asp Phe Asp Val Val Pro Ser Thr
2945                2950                2955                2960
Ser Cys Ser His Asp Tyr Leu Ala Ile Tyr Asp Gly Ala Asn Thr Ser
                2965                2970                2975
Asp Pro Leu Leu Gly Lys Phe Cys Gly Ser Lys Arg Pro Pro Asn Val
            2980                2985                2990
Lys Ser Ser Asn Asn Ser Met Leu Leu Val Phe Lys Thr Asp Ser Phe
        2995                3000                3005
Gln Thr Ala Lys Gly Trp Lys Met Ser Phe Arg Gln Thr Leu Gly Pro
    3010                3015                3020
Gln Gln Gly Cys Gly Gly Tyr Leu Thr Gly Ser Asn Asn Thr Phe Ala
3025                3030                3035                3040
Ser Pro Asp Ser Asp Ser Asn Gly Met Tyr Asp Lys Asn Leu Asn Cys
                3045                3050                3055
Val Trp Ile Ile Ile Ala Pro Val Asn Lys Val Ile His Leu Thr Phe
            3060                3065                3070
Asn Thr Phe Ala Leu Glu Ala Ala Ser Thr Arg Gln Arg Cys Leu Tyr
        3075                3080                3085
Asp Tyr Val Lys Leu Tyr Asp Gly Asp Ser Glu Asn Ala Asn Leu Ala
    3090                3095                3100
Gly Thr Phe Cys Gly Ser Thr Val Pro Ala Pro Phe Ile Ser Ser Gly
3105                3110                3115                3120
Asn Phe Leu Thr Val Gln Phe Ile Ser Asp Leu Thr Leu Glu Arg Glu
                3125                3130                3135
Gly Phe Asn Ala Thr Tyr Thr Ile Met Asp Met Pro Cys Gly Gly Thr
            3140                3145                3150
Tyr Asn Ala Thr Trp Thr Pro Gln Asn Ile Ser Ser Pro Asn Ser Ser
        3155                3160                3165
Asp Pro Asp Val Pro Phe Ser Ile Cys Thr Trp Val Ile Asp Ser Pro
    3170                3175                3180
Pro His Gln Gln Val Lys Ile Thr Val Trp Ala Leu Gln Leu Thr Ser
3185                3190                3195                3200
Gln Asp Cys Thr Gln Asn Tyr Leu Gln Leu Gln Asp Ser Pro Gln Gly
                3205                3210                3215
His Gly Asn Ser Arg Phe Gln Phe Cys Gly Arg Asn Ala Ser Ala Val
            3220                3225                3230
Pro Val Phe Tyr Ser Ser Met Ser Thr Ala Met Val Ile Phe Lys Ser
        3235                3240                3245
Gly Val Val Asn Arg Asn Ser Arg Met Ser Phe Thr Tyr Gln Ile Ala
    3250                3255                3260
Asp Cys Asn Arg Asp Tyr His Lys Ala Phe Gly Asn Leu Arg Ser Pro
3265                3270                3275                3280
Gly Trp Pro Asp Asn Tyr Asp Asn Asp Lys Asp Cys Thr Val Thr Leu
                3285                3290                3295
Thr Ala Pro Gln Asn His Thr Ile Ser Leu Phe Phe His Ser Leu Gly
            3300                3305                3310
Ile Glu Asn Ser Val Glu Cys Arg Asn Asp Phe Leu Glu Val Arg Asn
        3315                3320                3325
Gly Ser Asn Ser Asn Ser Pro Leu Leu Gly Lys Tyr Cys Gly Thr Leu
    3330                3335                3340
Leu Pro Asn Pro Val Phe Ser Gln Asn Asn Glu Leu Tyr Leu Arg Phe
3345                3350                3355                3360
Lys Ser Asp Ser Val Thr Ser Asp Arg Gly Tyr Glu Ile Ile Trp Thr
                3365                3370                3375
Ser Ser Pro Ser Gly Cys Gly Gly Thr Leu Tyr Gly Asp Arg Gly Ser
            3380                3385                3390
Phe Thr Ser Pro Gly Tyr Pro Gly Thr Tyr Pro Asn Asn Thr Tyr Cys
        3395                3400                3405
Glu Trp Val Leu Val Ala Pro Ala Gly Arg Leu Val Thr Ile Asn Phe
    3410                3415                3420
Tyr Phe Ile Ser Ile Asp Asp Pro Gly Asp Cys Val Gln Asn Tyr Leu
3425                3430                3435                3440
Thr Leu Tyr Asp Gly Pro Asn Ala Ser Ser Pro Ser Ser Gly Pro Tyr
                3445                3450                3455
Cys Gly Gly Asp Thr Ser Ile Ala Pro Phe Val Ala Ser Ser Asn Gln
            3460                3465                3470
Val Phe Ile Lys Phe His Ala Asp Tyr Ala Arg Arg Pro Ser Ala Phe
        3475                3480                3485
Arg Leu Thr Trp Asp Ser
    3490

<210> 704
<211> 452
<212> PRT
<213> Homo sapiens

<400> 704
Met Asp Ala Pro Ala Arg Leu Leu Ala Pro Leu Leu Leu Leu Cys Ala
 1               5                  10                  15
Gln Gln Leu Arg Gly Thr Arg Ala Met Asn Asp Ile Gly Asp Tyr Val
            20                  25                  30
Gly Ser Asn Leu Glu Ile Ser Trp Leu Pro Asn Leu Asp Gly Leu Ile
        35                  40                  45
Ala Gly Tyr Ala Arg Asn Phe Arg Pro Gly Ile Gly Gly Pro Pro Val
    50                  55                  60
Asn Val Ala Leu Ala Leu Glu Val Ala Ser Ile Asp His Ile Ser Glu
65                  70                  75                  80
Ala Asn Met Glu Tyr Thr Met Thr Val Phe Leu His Gln Ser Trp Arg
                85                  90                  95
Asp Ser Arg Leu Ser Tyr Asn His Thr Asn Glu Thr Leu Gly Leu Asp
            100                 105                 110
Ser Arg Phe Val Asp Lys Leu Trp Leu Pro Asp Thr Phe Ile Val Asn
        115                 120                 125
Ala Lys Ser Ala Trp Phe His Asp Val Thr Val Glu Asn Lys Leu Ile
    130                 135                 140
Arg Leu Gln Pro Asp Gly Val Ile Leu Tyr Ser Ile Arg Ile Thr Ser
145                 150                 155                 160
Thr Val Ala Cys Asp Met Asp Leu Ala Lys Tyr Pro Met Asp Glu Gln
                165                 170                 175
Glu Cys Met Leu Asp Leu Glu Ser Tyr Gly Tyr Ser Ser Glu Asp Ile
            180                 185                 190
Val Tyr Tyr Trp Ser Glu Ser Gln Glu His Ile His Gly Leu Asp Lys
        195                 200                 205
Leu Gln Leu Ala Gln Phe Thr Ile Thr Ser Tyr His Phe Thr Thr Glu
    210                 215                 220
Leu Met Asn Phe Lys Ser Ala Gly Gln Phe Pro Arg Leu Ser Leu His
225                 230                 235                 240
Phe His Leu Arg Arg Asn Arg Gly Val Tyr Ile Ile Gln Ser Tyr Met
                245                 250                 255
Pro Ser Val Leu Leu Val Ala Met Ser Trp Val Ser Phe Trp Ile Ser
            260                 265                 270
Gln Ala Ala Val Pro Ala Arg Val Ser Leu Gly Ile Thr Thr Val Leu
        275                 280                 285
Thr Met Thr Thr Leu Met Val Ser Ala Arg Ser Ser Leu Pro Arg Ala
    290                 295                 300
Ser Ala Ile Lys Ala Leu Asp Val Tyr Phe Trp Ile Cys Tyr Val Phe
305                 310                 315                 320
Val Phe Ala Ala Leu Val Glu Tyr Ala Phe Ala His Phe Asn Ala Asp
                325                 330                 335
Tyr Arg Lys Lys Gln Lys Ala Lys Val Lys Val Ser Arg Pro Arg Ala
            340                 345                 350
Glu Met Asp Val Arg Asn Ala Ile Val Leu Phe Ser Leu Ser Ala Ala
        355                 360                 365
Gly Val Thr Gln Glu Leu Ala Ile Ser Arg Arg Gln Arg Arg Val Pro
    370                 375                 380
Gly Asn Leu Met Gly Ser Tyr Arg Ser Val Gly Val Glu Thr Gly Glu
385                 390                 395                 400
Thr Lys Lys Glu Gly Ala Ala Arg Ser Gly Gly Gln Gly Gly Ile Arg
                405                 410                 415
Ala Arg Leu Arg Pro Ile Asp Ala Asp Thr Ile Asp Ile Tyr Ala Arg
            420                 425                 430
Ala Val Phe Pro Ala Ala Phe Ala Ala Val Asn Val Ile Tyr Trp Ala
        435                 440                 445
Ala Tyr Ala Met
    450

<210> 705
<211> 452
<212> PRT
<213> Homo sapiens

<400> 705
Met Asp Ala Pro Ala Arg Leu Leu Ala Pro Leu Leu Leu Leu Cys Ala
 1               5                  10                  15
Gln Gln Leu Arg Gly Thr Arg Ala Met Asn Asp Ile Gly Asp Tyr Val
            20                  25                  30
Gly Ser Asn Leu Glu Ile Ser Trp Leu Pro Asn Leu Asp Gly Leu Ile
        35                  40                  45
Ala Gly Tyr Ala Arg Asn Phe Arg Pro Gly Ile Gly Gly Pro Pro Val
    50                  55                  60
Asn Val Ala Leu Ala Leu Glu Val Ala Ser Ile Asp His Ile Ser Glu
65                  70                  75                  80
Ala Asn Met Glu Tyr Thr Met Thr Val Phe Leu His Gln Ser Trp Arg
                85                  90                  95
Asp Ser Arg Leu Ser Tyr Asn His Thr Asn Glu Thr Leu Gly Leu Asp
            100                 105                 110
Ser Arg Phe Val Asp Lys Leu Trp Leu Pro Asp Thr Phe Ile Val Asn
        115                 120                 125
Ala Lys Ser Ala Trp Phe His Asp Val Thr Val Glu Asn Lys Leu Ile
    130                 135                 140
Arg Leu Gln Pro Asp Gly Val Ile Leu Tyr Ser Ile Arg Ile Thr Ser
145                 150                 155                 160
Thr Val Ala Cys Asp Met Asp Leu Ala Lys Phe Pro Met Asp Glu Gln
                165                 170                 175
Glu Cys Met Leu Asp Leu Glu Ser Tyr Gly Tyr Ser Ser Glu Asp Ile
            180                 185                 190
Val Tyr Tyr Trp Ser Glu Ser Gln Glu His Ile His Gly Leu Asp Lys
        195                 200                 205
Leu Gln Leu Ala Gln Phe Thr Ile Thr Ser Tyr Arg Phe Thr Thr Glu
    210                 215                 220
Leu Met Asn Phe Lys Ser Ala Gly Gln Phe Pro Arg Leu Ser Leu His
225                 230                 235                 240
Phe His Leu Arg Arg Asn Arg Gly Val Tyr Ile Ile Gln Ser Tyr Met
                245                 250                 255
Pro Ser Val Leu Leu Val Ala Met Ser Trp Val Ser Phe Trp Ile Ser
            260                 265                 270
Gln Ala Ala Val Pro Ala Arg Val Ser Leu Gly Ile Thr Thr Val Leu
        275                 280                 285
Thr Met Thr Thr Leu Met Val Ser Ala Arg Ser Ser Leu Pro Arg Ala
    290                 295                 300
Ser Ala Ile Lys Ala Leu Asp Val Tyr Phe Trp Ile Cys Tyr Val Phe
305                 310                 315                 320
Val Phe Ala Ala Leu Val Glu Tyr Ala Phe Ala His Phe Asn Ala Asp
                325                 330                 335
Tyr Arg Lys Lys Gln Lys Ala Lys Val Lys Val Ser Arg Pro Arg Ala
            340                 345                 350
Glu Met Asp Val Arg Asn Ala Ile Val Leu Phe Ser Leu Ser Ala Ala
        355                 360                 365
Gly Val Thr Gln Glu Leu Ala Ile Ser Arg Arg Gln Arg Arg Val Pro
    370                 375                 380
Gly Asn Leu Met Gly Ser Tyr Arg Ser Val Gly Val Glu Thr Gly Glu
385                 390                 395                 400
Thr Lys Lys Glu Gly Ala Ala Arg Ser Gly Gly Gln Gly Gly Ile Arg
                405                 410                 415
Ala Arg Leu Arg Pro Ile Asp Ala Asp Thr Ile Asp Ile Tyr Ala Arg
            420                 425                 430
Ala Val Phe Pro Ala Ala Phe Ala Ala Val Asn Val Ile Tyr Trp Ala
        435                 440                 445
Ala Tyr Ala Met
    450

<210> 706
<211> 452
<212> PRT
<213> Homo sapiens

<400> 706
Met Asp Ala Pro Ala Arg Leu Leu Ala Pro Leu Leu Leu Leu Cys Ala
 1               5                  10                  15
Gln Gln Leu Arg Gly Thr Arg Ala Met Asn Asp Ile Gly Asp Tyr Val
            20                  25                  30
Gly Ser Asn Leu Glu Ile Ser Trp Leu Pro Asn Leu Asp Gly Leu Ile
        35                  40                  45
Ala Gly Tyr Ala Arg Asn Phe Arg Pro Gly Ile Gly Gly Pro Pro Val
    50                  55                  60
Asn Val Ala Leu Ala Leu Glu Val Ala Ser Ile Asp His Ile Ser Glu
65                  70                  75                  80
Ala Asn Met Glu Tyr Thr Met Thr Val Phe Leu His Gln Ser Trp Arg
                85                  90                  95
Asp Ser Arg Leu Ser Tyr Asn His Thr Asn Glu Thr Leu Gly Leu Asp
            100                 105                 110
Ser Arg Phe Val Asp Lys Leu Trp Leu Pro Asp Thr Phe Ile Val Asn
        115                 120                 125
Ala Lys Ser Ala Trp Phe His Asp Val Thr Val Glu Asn Lys Leu Ile
    130                 135                 140
Arg Leu Gln Pro Asp Gly Val Ile Leu Tyr Ser Ile Arg Ile Thr Ser
145                 150                 155                 160
Thr Val Ala Cys Asp Met Asp Leu Ala Lys Tyr Pro Met Asp Glu Gln
                165                 170                 175
Glu Cys Met Leu Asp Leu Glu Ser Tyr Gly Tyr Ser Ser Glu Asp Ile
            180                 185                 190
Val Tyr Tyr Trp Ser Glu Ser Gln Glu His Ile His Gly Leu Asp Lys
        195                 200                 205
Leu Gln Leu Ala Gln Phe Thr Ile Thr Ser Tyr His Phe Thr Thr Glu
    210                 215                 220
Leu Met Asn Phe Lys Ser Ala Gly Gln Phe Pro Arg Leu Ser Leu His
225                 230                 235                 240
Phe His Leu Arg Arg Asn Arg Gly Val Tyr Ile Ile Gln Ser Tyr Met
                245                 250                 255
Pro Ser Val Leu Leu Val Ala Met Ser Trp Val Ser Phe Trp Ile Ser
            260                 265                 270
Gln Ala Ala Val Pro Ala Arg Val Ser Leu Gly Ile Thr Thr Val Leu
        275                 280                 285
Thr Met Thr Thr Leu Met Val Ser Ala Arg Ser Ser Leu Pro Arg Ala
    290                 295                 300
Ser Ala Ile Lys Ala Leu Asp Val Tyr Phe Trp Ile Cys Tyr Val Phe
305                 310                 315                 320
Val Phe Ala Ala Leu Val Glu Tyr Ala Phe Ala His Phe Asn Ala Asp
                325                 330                 335
Tyr Arg Lys Lys Gln Lys Ala Lys Val Lys Val Ser Arg Pro Arg Ala
            340                 345                 350
Glu Met Asp Val Arg Asn Ala Ile Val Leu Phe Ser Leu Ser Ala Ala
        355                 360                 365
Gly Val Thr Gln Glu Leu Ala Ile Ser Arg Arg Gln Arg Arg Val Pro
    370                 375                 380
Gly Asn Leu Met Gly Ser Tyr Arg Ser Val Gly Val Glu Thr Gly Glu
385                 390                 395                 400
Thr Lys Lys Glu Gly Ala Ala Arg Ser Gly Gly Gln Gly Gly Ile Arg
                405                 410                 415
Ala Arg Leu Arg Pro Ile Asp Ala Asp Thr Ile Asp Ile Tyr Ala Arg
            420                 425                 430
Ala Val Phe Pro Ala Ala Phe Ala Ala Val Asn Val Ile Tyr Trp Ala
        435                 440                 445
Ala Tyr Ala Met
    450

<210> 707
<211> 452
<212> PRT
<213> Homo sapiens

<400> 707
Met Asp Ala Pro Ala Arg Leu Leu Ala Pro Leu Leu Leu Leu Cys Ala
 1               5                  10                  15
Gln Gln Leu Arg Gly Thr Arg Ala Met Asn Asp Ile Gly Asp Tyr Val
            20                  25                  30
Gly Ser Asn Leu Glu Ile Ser Trp Leu Pro Asn Leu Asp Gly Leu Ile
        35                  40                  45
Ala Gly Tyr Ala Arg Asn Phe Arg Pro Gly Ile Gly Gly Pro Pro Val
    50                  55                  60
Asn Val Ala Leu Ala Leu Glu Val Ala Ser Ile Asp His Ile Ser Glu
65                  70                  75                  80
Ala Asn Met Glu Tyr Thr Met Thr Val Phe Leu His Gln Ser Trp Arg
                85                  90                  95
Asp Ser Arg Leu Ser Tyr Asn His Thr Asn Glu Thr Leu Gly Leu Asp
            100                 105                 110
Ser Arg Phe Val Asp Lys Leu Trp Leu Pro Asp Thr Phe Ile Val Asn
        115                 120                 125
Ala Lys Ser Ala Trp Phe His Asp Val Thr Val Glu Asn Lys Leu Ile
    130                 135                 140
Arg Leu Gln Pro Asp Gly Val Ile Leu Tyr Ser Ile Arg Ile Thr Ser
145                 150                 155                 160
Thr Val Ala Cys Asp Met Asp Leu Ala Lys Tyr Pro Met Asp Glu Gln
                165                 170                 175
Glu Cys Met Leu Asp Leu Glu Ser Tyr Gly Tyr Ser Ser Glu Asp Ile
            180                 185                 190
Val Tyr Tyr Trp Ser Glu Ser Gln Glu His Ile His Gly Leu Asp Lys
        195                 200                 205
Leu Gln Leu Ala Gln Phe Thr Ile Thr Ser Tyr His Phe Thr Thr Glu
    210                 215                 220
Leu Met Asn Phe Lys Ser Ala Gly Gln Phe Pro Arg Leu Ser Leu His
225                 230                 235                 240
Phe His Leu Arg Arg Asn Arg Gly Val Tyr Ile Ile Gln Ser Tyr Met
                245                 250                 255
Pro Ser Val Leu Leu Val Ala Met Ser Trp Val Ser Phe Trp Ile Ser
            260                 265                 270
Gln Ala Ala Val Pro Ala Arg Val Ser Leu Gly Ile Thr Thr Val Leu
        275                 280                 285
Thr Met Thr Thr Leu Met Val Ser Ala Arg Ser Ser Leu Pro Arg Ala
    290                 295                 300
Ser Ala Ile Lys Ala Leu Asp Val Tyr Phe Trp Ile Cys Tyr Val Phe
305                 310                 315                 320
Val Phe Ala Ala Leu Val Glu Tyr Ala Phe Ala His Phe Asn Ala Asp
                325                 330                 335
Tyr Arg Lys Lys Gln Lys Ala Lys Val Lys Val Ser Arg Pro Arg Ala
            340                 345                 350
Glu Met Asp Val Arg Asn Ala Ile Val Leu Phe Ser Leu Ser Ala Ala
        355                 360                 365
Gly Val Thr Gln Glu Leu Ala Ile Ser Arg Arg Gln Arg Arg Val Pro
    370                 375                 380
Gly Asn Leu Met Gly Ser Tyr Arg Ser Val Gly Val Glu Thr Gly Glu
385                 390                 395                 400
Thr Lys Lys Glu Gly Ala Ala Arg Ser Gly Gly Gln Gly Gly Ile Arg
                405                 410                 415
Ala Arg Leu Arg Pro Ile Asp Ala Asp Thr Ile Asp Ile Tyr Ala Arg
            420                 425                 430
Ala Val Phe Pro Ala Ala Phe Ala Ala Val Asn Val Ile Tyr Trp Ala
        435                 440                 445
Ala Tyr Ala Met
    450

<210> 708
<211> 769
<212> PRT
<213> Homo sapiens

<400> 708
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile
    690                 695                 700
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu
705                 710                 715                 720
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg
                725                 730                 735
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro
            740                 745                 750
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu
        755                 760                 765
Ser


<210> 709
<211> 378
<212> PRT
<213> Homo sapiens

<400> 709
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Phe Gly
            100                 105                 110
Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Asn Thr His Pro Asp
        115                 120                 125
Lys Leu Arg Asn Pro Cys Pro Asn Lys Glu Lys Glu Cys Gln Pro Pro
    130                 135                 140
Phe Ala Phe Arg His Val Leu Lys Leu Thr Asn Asn Ser Asn Gln Phe
145                 150                 155                 160
Gln Thr Glu Val Gly Lys Gln Leu Ile Ser Gly Asn Leu Asp Ala Pro
                165                 170                 175
Glu Gly Gly Leu Asp Ala Met Met Gln Val Ala Ala Cys Pro Glu Glu
            180                 185                 190
Ile Gly Trp Arg Asn Val Thr Arg Leu Leu Val Phe Ala Thr Asp Asp
        195                 200                 205
Gly Phe His Phe Ala Gly Asp Gly Lys Leu Gly Ala Ile Leu Thr Pro
    210                 215                 220
Asn Asp Gly Arg Cys His Leu Glu Asp Asn Leu Tyr Lys Arg Ser Asn
225                 230                 235                 240
Glu Phe Asp Tyr Pro Ser Val Gly Gln Leu Ala His Lys Leu Ala Glu
                245                 250                 255
Asn Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Arg Met Val Lys Thr
            260                 265                 270
Tyr Glu Lys Leu Thr Glu Ile Ile Pro Lys Ser Ala Val Gly Glu Leu
        275                 280                 285
Ser Glu Asp Ser Ser Asn Val Val His Leu Ile Lys Asn Ala Tyr Asn
    290                 295                 300
Lys Leu Ser Ser Arg Val Phe Leu Asp His Asn Ala Leu Pro Asp Thr
305                 310                 315                 320
Leu Lys Val Thr Tyr Asp Ser Phe Cys Ser Asn Gly Val Thr His Arg
                325                 330                 335
Asn Gln Pro Arg Val Asp Cys Asp Gly Val Gln Ile Asn Val Pro Ile
            340                 345                 350
Thr Phe Gln Val Lys Val Thr Ala Thr Glu Cys Ile Gln Glu Gln Ser
        355                 360                 365
Phe Val Ile Gly Arg Trp Ala Ser Arg Thr
    370                 375

<210> 710
<211> 769
<212> PRT
<213> Homo sapiens

<400> 710
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile
    690                 695                 700
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu
705                 710                 715                 720
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg
                725                 730                 735
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro
            740                 745                 750
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu
        755                 760                 765
Ser


<210> 711
<211> 761
<212> PRT
<213> Homo sapiens

<400> 711
Leu Ala Leu Val Gly Leu Leu Ser Leu Gly Cys Val Leu Ser Gln Glu
 1               5                  10                  15
Cys Thr Lys Phe Lys Val Ser Ser Cys Arg Glu Cys Ile Glu Ser Gly
            20                  25                  30
Pro Gly Cys Thr Trp Cys Gln Lys Leu Asn Phe Thr Gly Pro Gly Asp
        35                  40                  45
Pro Asp Ser Ile Arg Cys Asp Thr Arg Pro Gln Leu Leu Met Arg Gly
    50                  55                  60
Cys Ala Ala Asp Asp Ile Met Asp Pro Thr Ser Leu Ala Glu Thr Gln
65                  70                  75                  80
Glu Asp His Asn Gly Gly Gln Lys Gln Leu Ser Pro Gln Lys Val Thr
                85                  90                  95
Leu Tyr Leu Arg Pro Gly Gln Ala Ala Ala Phe Asn Val Thr Phe Arg
            100                 105                 110
Arg Ala Lys Gly Tyr Pro Ile Asp Leu Tyr Tyr Leu Met Asp Leu Ser
        115                 120                 125
Tyr Ser Met Leu Asp Asp Leu Arg Asn Val Lys Lys Leu Gly Gly Asp
    130                 135                 140
Leu Leu Arg Ala Leu Asn Glu Ile Thr Glu Ser Gly Arg Ile Gly Phe
145                 150                 155                 160
Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Asn Thr His Pro
                165                 170                 175
Asp Lys Leu Arg Asn Pro Cys Pro Asn Lys Glu Lys Glu Cys Pro Pro
            180                 185                 190
Pro Phe Ala Phe Arg His Val Leu Lys Leu Thr Asn Asn Ser Asn Gln
        195                 200                 205
Phe Gln Thr Glu Val Gly Lys Gln Leu Ile Ser Gly Asn Leu Asp Ala
    210                 215                 220
Pro Glu Gly Gly Leu Asp Ala Met Met Gln Val Ala Ala Cys Pro Glu
225                 230                 235                 240
Glu Ile Gly Trp Arg Asn Val Thr Arg Leu Leu Val Phe Ala Thr Asp
                245                 250                 255
Asp Gly Phe His Phe Ala Gly Asp Gly Lys Leu Gly Ala Ile Leu Thr
            260                 265                 270
Pro Asn Asp Gly Arg Cys His Leu Glu Asp Asn Leu Tyr Lys Arg Ser
        275                 280                 285
Asn Glu Phe Asp Tyr Pro Ser Val Gly Gln Leu Ala His Lys Leu Ala
    290                 295                 300
Glu Asn Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Arg Met Val Lys
305                 310                 315                 320
Thr Tyr Glu Lys Leu Thr Glu Ile Ile Pro Lys Ser Ala Val Gly Glu
                325                 330                 335
Leu Ser Glu Asp Ser Ser Asn Val Val His Leu Ile Lys Asn Ala Tyr
            340                 345                 350
Asn Lys Leu Ser Ser Arg Val Phe Leu Asp His Asn Ala Leu Pro Asp
        355                 360                 365
Thr Leu Lys Val Thr Tyr Asp Ser Phe Cys Ser Asn Gly Val Thr His
    370                 375                 380
Arg Asn Gln Pro Arg Gly Asp Cys Asp Gly Val Gln Ile Asn Val Pro
385                 390                 395                 400
Ile Thr Phe Gln Val Lys Val Thr Ala Thr Glu Cys Ile Gln Glu Gln
                405                 410                 415
Ser Phe Val Ile Arg Ala Leu Gly Phe Thr Asp Ile Val Thr Val Gln
            420                 425                 430
Val Leu Pro Gln Cys Glu Cys Arg Cys Arg Asp Gln Ser Arg Asp Arg
        435                 440                 445
Ser Leu Cys His Gly Lys Gly Phe Leu Glu Cys Gly Ile Cys Arg Cys
    450                 455                 460
Asp Thr Gly Tyr Ile Gly Lys Asn Cys Glu Cys Gln Thr Gln Gly Arg
465                 470                 475                 480
Ser Ser Gln Glu Leu Glu Gly Ser Cys Arg Lys Asp Asn Asn Ser Ile
                485                 490                 495
Ile Cys Ser Gly Leu Gly Asp Cys Val Cys Gly Gln Cys Leu Cys His
            500                 505                 510
Thr Ser Asp Val Pro Gly Lys Leu Ile Tyr Gly Gln Tyr Cys Glu Cys
        515                 520                 525
Asp Thr Ile Asn Cys Glu Arg Tyr Asn Gly Gln Val Cys Gly Gly Pro
    530                 535                 540
Gly Arg Gly Leu Cys Phe Cys Gly Lys Cys Arg Cys His Pro Gly Phe
545                 550                 555                 560
Glu Gly Ser Ala Cys Gln Cys Glu Arg Thr Thr Glu Gly Cys Leu Asn
                565                 570                 575
Pro Arg Arg Val Glu Cys Ser Gly Arg Gly Arg Cys Arg Cys Asn Val
            580                 585                 590
Cys Glu Cys His Ser Gly Tyr Gln Leu Pro Leu Cys Gln Glu Cys Pro
        595                 600                 605
Gly Cys Pro Ser Pro Cys Gly Lys Tyr Ile Ser Cys Ala Glu Cys Leu
    610                 615                 620
Lys Phe Glu Lys Gly Pro Phe Gly Lys Asn Cys Ser Ala Ala Cys Pro
625                 630                 635                 640
Gly Leu Gln Leu Ser Asn Asn Pro Val Lys Gly Arg Thr Cys Lys Glu
                645                 650                 655
Arg Asp Ser Glu Gly Cys Trp Val Ala Tyr Thr Leu Glu Gln Gln Asp
            660                 665                 670
Gly Met Asp Arg Tyr Leu Ile Tyr Val Asp Glu Ser Arg Glu Cys Val
        675                 680                 685
Ala Gly Pro Asn Ile Ala Ala Ile Val Gly Gly Thr Val Ala Gly Ile
    690                 695                 700
Val Leu Ile Gly Ile Leu Leu Leu Val Ile Trp Lys Ala Leu Ile His
705                 710                 715                 720
Leu Ser Asp Leu Arg Glu Tyr Arg Arg Phe Glu Lys Glu Lys Leu Lys
                725                 730                 735
Ser Gln Trp Asn Asn Asp Asn Pro Leu Phe Lys Ser Ala Thr Thr Thr
            740                 745                 750
Val Met Asn Pro Lys Phe Ala Glu Ser
        755                 760

<210> 712
<211> 769
<212> PRT
<213> Homo sapiens

<400> 712
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val Gln Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile
    690                 695                 700
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu
705                 710                 715                 720
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg
                725                 730                 735
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro
            740                 745                 750
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu
        755                 760                 765
Ser


<210> 713
<211> 769
<212> PRT
<213> Homo sapiens

<400> 713
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile
    690                 695                 700
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu
705                 710                 715                 720
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg
                725                 730                 735
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro
            740                 745                 750
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu
        755                 760                 765
Ser


<210> 714
<211> 769
<212> PRT
<213> Homo sapiens

<400> 714
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile
    690                 695                 700
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu
705                 710                 715                 720
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg
                725                 730                 735
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro
            740                 745                 750
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu
        755                 760                 765
Ser


<210> 715
<211> 769
<212> PRT
<213> Homo sapiens

<400> 715
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Ala Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Asp Cys Val Ala Gly Pro Asn Ile Ala Ala Ile
    690                 695                 700
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu
705                 710                 715                 720
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg
                725                 730                 735
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro
            740                 745                 750
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu
        755                 760                 765
Ser


<210> 716
<211> 769
<212> PRT
<213> Homo sapiens

<400> 716
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile
    690                 695                 700
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu
705                 710                 715                 720
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg
                725                 730                 735
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro
            740                 745                 750
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu
        755                 760                 765
Ser


<210> 717
<211> 676
<212> PRT
<213> Homo sapiens

<400> 717
Gln Glu Cys Thr Lys Phe Lys Val Ser Ser Cys Arg Glu Cys Ile Glu
 1               5                  10                  15
Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys Leu Asn Phe Thr Gly Pro
            20                  25                  30
Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr Arg Pro Gln Leu Leu Met
        35                  40                  45
Arg Gly Cys Ala Ala Asp Asp Ile Met Asp Pro Thr Ser Leu Ala Glu
    50                  55                  60
Thr Gln Glu Asp His Asn Gly Gly Gln Lys Gln Leu Ser Pro Gln Lys
65                  70                  75                  80
Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala Ala Ala Phe Asn Val Thr
                85                  90                  95
Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp Leu Tyr Tyr Leu Met Asp
            100                 105                 110
Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg Asn Val Lys Lys Leu Gly
        115                 120                 125
Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile Thr Glu Ser Gly Arg Ile
    130                 135                 140
Gly Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Asn Thr
145                 150                 155                 160
His Pro Asp Lys Leu Arg Asn Pro Cys Pro Asn Lys Glu Lys Glu Cys
                165                 170                 175
Gln Pro Pro Phe Ala Phe Arg His Val Leu Lys Leu Thr Asn Asn Ser
            180                 185                 190
Asn Gln Phe Gln Thr Glu Val Gly Lys Gln Leu Ile Ser Gly Asn Leu
        195                 200                 205
Asp Ala Pro Glu Gly Gly Leu Asp Ala Met Met Gln Val Ala Ala Cys
    210                 215                 220
Pro Glu Glu Ile Gly Asn Arg Asn Val Thr Arg Leu Leu Val Phe Ala
225                 230                 235                 240
Thr Asp Asp Gly Phe His Phe Ala Gly Asp Gly Lys Leu Gly Ala Ile
                245                 250                 255
Leu Thr Pro Asn Asp Gly Arg Cys His Leu Glu Asp Asn Leu Tyr Lys
            260                 265                 270
Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val Gly Gln Leu Ala His Lys
        275                 280                 285
Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Arg Met
    290                 295                 300
Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile Ile Pro Lys Ser Ala Val
305                 310                 315                 320
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val His Leu Ile Lys Asn
                325                 330                 335
Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe Leu Asp His Asn Ala Leu
            340                 345                 350
Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser Phe Cys Ser Asn Gly Val
        355                 360                 365
Thr His Arg Asn Gln Pro Arg Gly Asp Cys Asp Gly Val Gln Ile Asn
    370                 375                 380
Val Pro Ile Thr Phe Gln Val Lys Val Thr Ala Thr Glu Cys Ile Gln
385                 390                 395                 400
Glu Gln Ser Phe Val Ile Arg Ala Leu Gly Phe Thr Asp Ile Val Thr
                405                 410                 415
Val Gln Val Leu Pro Gln Cys Glu Cys Arg Cys Arg Asp Gln Ser Arg
            420                 425                 430
Asp Arg Ser Leu Cys His Gly Lys Gly Phe Leu Glu Cys Gly Ile Cys
        435                 440                 445
Arg Cys Asp Thr Gln Tyr Ile Gly Lys Asn Cys Glu Cys Gln Thr Gln
    450                 455                 460
Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser Cys Arg Lys Asp Asn Asn
465                 470                 475                 480
Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys Val Cys Gly Gln Cys Leu
                485                 490                 495
Cys His Thr Ser Asp Val Pro Gly Lys Leu Ile Tyr Gly Gln Tyr Cys
            500                 505                 510
Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr Asn Gly Gln Val Cys Gly
        515                 520                 525
Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly Lys Cys Arg Cys His Pro
    530                 535                 540
Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu Arg Thr Thr Glu Gly Cys
545                 550                 555                 560
Leu Asn Pro Arg Arg Val Glu Cys Ser Gly Arg Gly Arg Cys Arg Cys
                565                 570                 575
Asn Val Cys Glu Cys His Ser Gly Tyr Gln Leu Pro Leu Cys Gln Glu
            580                 585                 590
Cys Pro Gly Cys Pro Ser Cys Gly Lys Tyr Ile Ser Cys Ala Glu Cys
        595                 600                 605
Leu Lys Phe Glu Lys Gly Pro Phe Gly Lys Asn Cys Ser Ala Ala Cys
    610                 615                 620
Pro Gly Leu Gln Leu Ser Asn Asn Pro Val Lys Gly Arg Thr Cys Lys
625                 630                 635                 640
Glu Arg Asp Ser Glu Gly Cys Trp Val Ala Tyr Thr Leu Glu Gln Gln
                645                 650                 655
Asp Gly Met Asp Arg Tyr Leu Ile Tyr Val Asp Glu Ser Arg Glu Cys
            660                 665                 670
Val Ala Gly Pro
        675

<210> 718
<211> 699
<212> PRT
<213> Homo sapiens

<400> 718
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro
    690                 695

<210> 719
<211> 769
<212> PRT
<213> Homo sapiens

<400> 719
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile
    690                 695                 700
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu
705                 710                 715                 720
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg
                725                 730                 735
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro
            740                 745                 750
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu
        755                 760                 765
Ser


<210> 720
<211> 769
<212> PRT
<213> Homo sapiens

<400> 720
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser
 1               5                  10                  15
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser
            20                  25                  30
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys
        35                  40                  45
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr
    50                  55                  60
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp
65                  70                  75                  80
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys
                85                  90                  95
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala
            100                 105                 110
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp
        115                 120                 125
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg
    130                 135                 140
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile
145                 150                 155                 160
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val
                165                 170                 175
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro
            180                 185                 190
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu
        195                 200                 205
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
    210                 215                 220
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met
225                 230                 235                 240
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr
                245                 250                 255
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp
            260                 265                 270
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu
        275                 280                 285
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val
    290                 295                 300
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe
305                 310                 315                 320
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile
                325                 330                 335
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val
            340                 345                 350
Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe
        355                 360                 365
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser
    370                 375                 380
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys
385                 390                 395                 400
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr
                405                 410                 415
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly
            420                 425                 430
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg
        435                 440                 445
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe
    450                 455                 460
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn
465                 470                 475                 480
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser
                485                 490                 495
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys
            500                 505                 510
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu
        515                 520                 525
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr
    530                 535                 540
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly
545                 550                 555                 560
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu
                565                 570                 575
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly
            580                 585                 590
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln
        595                 600                 605
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys
    610                 615                 620
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly
625                 630                 635                 640
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
                645                 650                 655
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val
            660                 665                 670
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr
        675                 680                 685
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile
    690                 695                 700
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu
705                 710                 715                 720
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg
                725                 730                 735
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro
            740                 745                 750
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu
        755                 760                 765
Ser


<210> 721
<211> 532
<212> PRT
<213> Homo sapiens

<400> 721
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 722
<211> 532
<212> PRT
<213> Homo sapiens

<400> 722
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 723
<211> 532
<212> PRT
<213> Homo sapiens

<400> 723
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 724
<211> 43
<212> PRT
<213> Homo sapiens

<400> 724
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Glu Ser Gly Trp Gly Leu Pro Ser Gly
            20                  25                  30
Gln Phe Ser Glu Ala Arg Glu Asp Arg Leu Pro
        35                  40

<210> 725
<211> 532
<212> PRT
<213> Homo sapiens

<400> 725
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 726
<211> 532
<212> PRT
<213> Homo sapiens

<400> 726
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 727
<211> 451
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(451)
<223> Xaa = Any Amino Acid

<400> 727
Ser Thr His Ala Ser Ala His Ala Ser Ala Ala Thr Gln Ser Cys Asn
 1               5                  10                  15
Leu Ser Leu Ala Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala
            20                  25                  30
Leu Leu Val Leu Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln
        35                  40                  45
Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val
    50                  55                  60
Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile
65                  70                  75                  80
Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg
                85                  90                  95
Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys
            100                 105                 110
Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr
        115                 120                 125
Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp
    130                 135                 140
Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly
145                 150                 155                 160
Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu
                165                 170                 175
Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr
            180                 185                 190
Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr
        195                 200                 205
Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser
    210                 215                 220
Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln
225                 230                 235                 240
Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val
                245                 250                 255
Cys Ser Leu Asp Gly Leu Phe Pro Val Xaa Glu Ala Gln Val Xaa Leu
            260                 265                 270
Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp
        275                 280                 285
Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly
    290                 295                 300
Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu
305                 310                 315                 320
Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile
                325                 330                 335
Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys
            340                 345                 350
Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln
        355                 360                 365
Pro Leu Gly Pro Arg Ala Ser Cys Leu Leu Lys Ala Thr Pro Glu Asp
    370                 375                 380
Asn Gly Arg Xaa Ser Pro Ala Leu Gln Pro Trp Arg Trp Pro Ala Ser
385                 390                 395                 400
Leu Tyr Thr Arg Thr Arg Pro Gly Ser Phe Val Ser Cys Met Ala Pro
                405                 410                 415
Asp Trp Thr Arg Gly Ile Val Arg Glu Thr Gly Arg Gly Gln Lys Ile
            420                 425                 430
Pro Ser Arg Leu Gln Cys Ala Arg Leu Gly Gly Thr His Cys Pro Ser
        435                 440                 445
Ser Ser Val
    450

<210> 728
<211> 562
<212> PRT
<213> Homo sapiens

<400> 728
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Pro Ser Trp Gln Pro Val Gly Lys Asn
145                 150                 155                 160
Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala Asn Leu
                165                 170                 175
Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu Pro Ala
            180                 185                 190
Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg Arg Asp
        195                 200                 205
His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu Arg Pro
    210                 215                 220
Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln Leu Gln
225                 230                 235                 240
Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro Arg Val
                245                 250                 255
Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp Gly Leu
            260                 265                 270
Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp Gln Arg
        275                 280                 285
Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala Lys Ala
    290                 295                 300
Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu Thr Cys
305                 310                 315                 320
Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr Val Thr
                325                 330                 335
Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro Glu Val
            340                 345                 350
Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro Arg Ala
        355                 360                 365
Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro Arg Ala
    370                 375                 380
Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser Phe Ser
385                 390                 395                 400
Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys Asn Gln
                405                 410                 415
Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu Arg Asp
            420                 425                 430
Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr Pro Met
        435                 440                 445
Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu Lys Asp
    450                 455                 460
Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr Arg Asp
465                 470                 475                 480
Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly Glu Val
                485                 490                 495
Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu Ile Val
            500                 505                 510
Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala Gly Leu
        515                 520                 525
Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr Arg Leu
    530                 535                 540
Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln Ala Thr
545                 550                 555                 560
Pro Pro


<210> 729
<211> 532
<212> PRT
<213> Homo sapiens

<400> 729
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Arg Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 730
<211> 480
<212> PRT
<213> Homo sapiens

<400> 730
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Lys Pro Pro Gly Met Arg Leu Ser Ser Ser Leu Trp
465                 470                 475                 480

<210> 731
<211> 532
<212> PRT
<213> Homo sapiens

<400> 731
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 732
<211> 532
<212> PRT
<213> Homo sapiens

<400> 732
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Thr Pro
    210                 215                 220
Pro Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Arg Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Cys Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Pro Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Lys Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Val Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 733
<211> 532
<212> PRT
<213> Homo sapiens

<400> 733
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 734
<211> 532
<212> PRT
<213> Homo sapiens

<400> 734
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 735
<211> 532
<212> PRT
<213> Homo sapiens

<400> 735
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Arg Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Pro Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Arg Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Arg Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 736
<211> 531
<212> PRT
<213> Homo sapiens

<400> 736
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr Pro
            100                 105                 110
Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly Lys
        115                 120                 125
Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala Asn
    130                 135                 140
Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu Pro
145                 150                 155                 160
Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg Arg
                165                 170                 175
Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu Arg
            180                 185                 190
Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln Leu
        195                 200                 205
Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro Arg
    210                 215                 220
Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp Gly
225                 230                 235                 240
Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp Gln
                245                 250                 255
Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala Lys
            260                 265                 270
Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu Thr
        275                 280                 285
Cys Ala Val Ile Ile Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr Val
    290                 295                 300
Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro Glu
305                 310                 315                 320
Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro Arg
                325                 330                 335
Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro Arg
            340                 345                 350
Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser Phe
        355                 360                 365
Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys Asn
    370                 375                 380
Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu Arg
385                 390                 395                 400
Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr Pro
                405                 410                 415
Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu Lys
            420                 425                 430
Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr Arg
        435                 440                 445
Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly Glu
    450                 455                 460
Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu Ile
465                 470                 475                 480
Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala Gly
                485                 490                 495
Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr Arg
            500                 505                 510
Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln Ala
        515                 520                 525
Thr Pro Pro
    530

<210> 737
<211> 532
<212> PRT
<213> Homo sapiens

<400> 737
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 738
<211> 532
<212> PRT
<213> Homo sapiens

<400> 738
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 739
<211> 532
<212> PRT
<213> Homo sapiens

<400> 739
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 740
<211> 532
<212> PRT
<213> Homo sapiens

<400> 740
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 741
<211> 532
<212> PRT
<213> Homo sapiens

<400> 741
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 742
<211> 508
<212> PRT
<213> Homo sapiens

<400> 742
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Arg Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly
                485                 490                 495
Thr Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 743
<211> 532
<212> PRT
<213> Homo sapiens

<400> 743
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Glu Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 744
<211> 532
<212> PRT
<213> Homo sapiens

<400> 744
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 745
<211> 532
<212> PRT
<213> Homo sapiens

<400> 745
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 746
<211> 532
<212> PRT
<213> Homo sapiens

<400> 746
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Ala Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Cys Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 747
<211> 532
<212> PRT
<213> Homo sapiens

<400> 747
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Ala Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Cys Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 748
<211> 532
<212> PRT
<213> Homo sapiens

<400> 748
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 749
<211> 481
<212> PRT
<213> Homo sapiens

<400> 749
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Val


<210> 750
<211> 532
<212> PRT
<213> Homo sapiens

<400> 750
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 751
<211> 532
<212> PRT
<213> Homo sapiens

<400> 751
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 752
<211> 532
<212> PRT
<213> Homo sapiens

<400> 752
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 753
<211> 43
<212> PRT
<213> Homo sapiens

<400> 753
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Glu Ser Gly Trp Gly Leu Pro Ser Gly
            20                  25                  30
Gln Phe Ser Glu Ala Arg Glu Asp Arg Leu Pro
        35                  40

<210> 754
<211> 532
<212> PRT
<213> Homo sapiens

<400> 754
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460
Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525
Ala Thr Pro Pro
    530

<210> 755
<211> 1651
<212> PRT
<213> Homo sapiens

<400> 755
Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser
 1               5                  10                  15
Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu
            20                  25                  30
Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp
        35                  40                  45
Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu
    50                  55                  60
Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser
65                  70                  75                  80
Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr
                85                  90                  95
Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys
            100                 105                 110
Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe
        115                 120                 125
Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val
    130                 135                 140
Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn
145                 150                 155                 160
Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro
                165                 170                 175
Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln
            180                 185                 190
Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly
        195                 200                 205
Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys
    210                 215                 220
Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys
225                 230                 235                 240
Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu
                245                 250                 255
Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala
            260                 265                 270
Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp
        275                 280                 285
Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys
    290                 295                 300
Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val
305                 310                 315                 320
Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val
                325                 330                 335
Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His
            340                 345                 350
Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val
        355                 360                 365
Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp
    370                 375                 380
Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln
385                 390                 395                 400
Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr
                405                 410                 415
Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn
            420                 425                 430
Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val
        435                 440                 445
Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln
    450                 455                 460
Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly
465                 470                 475                 480
Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser
                485                 490                 495
Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile
            500                 505                 510
Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser
        515                 520                 525
Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu
    530                 535                 540
Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile
545                 550                 555                 560
Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr
                565                 570                 575
Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr
            580                 585                 590
Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln
        595                 600                 605
Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu
    610                 615                 620
Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr
625                 630                 635                 640
Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp
                645                 650                 655
Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu
            660                 665                 670
Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser
        675                 680                 685
Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile
    690                 695                 700
Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu
705                 710                 715                 720
Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val
                725                 730                 735
Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg
            740                 745                 750
Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala
        755                 760                 765
Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val
    770                 775                 780
Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro
785                 790                 795                 800
Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp
                805                 810                 815
Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly
            820                 825                 830
Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr
        835                 840                 845
Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser
    850                 855                 860
Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro
865                 870                 875                 880
Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln
                885                 890                 895
Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met
            900                 905                 910
Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu
        915                 920                 925
Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr
    930                 935                 940
Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly
945                 950                 955                 960
Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu
                965                 970                 975
Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile
            980                 985                 990
Ser Cys Cys Thr Ala Gly Asn Gly Asn Ser Asp Ser Asn Leu Thr Thr
        995                 1000                1005
Tyr Ser Arg Pro Ala Asp Cys Ile Ala Asn Tyr Asn Asn Gln Leu Asp
    1010                1015                1020
Asn Lys Gln Thr Asn Leu Met Leu Pro Glu Ser Thr Val Tyr Gly Asp
1025                1030                1035                1040
Val Asp Leu Ser Asn Lys Ile Asn Glu Met Lys Thr Phe Asn Ser Pro
                1045                1050                1055
Asn Leu Lys Asp Gly Arg Phe Val Asn Pro Ser Gly Gln Pro Thr Pro
            1060                1065                1070
Tyr Ala Thr Thr Gln Leu Ile Gln Ser Asn Leu Ser Asn Asn Met Asn
        1075                1080                1085
Asn Gly Ser Gly Asp Ser Gly Glu Lys His Trp Lys Pro Leu Gly Gln
    1090                1095                1100
Gln Lys Gln Glu Val Ala Pro Val Gln Tyr Asn Ile Val Glu Gln Asn
1105                1110                1115                1120
Lys Leu Asn Lys Asp Tyr Arg Ala Asn Asp Thr Val Pro Pro Thr Ile
                1125                1130                1135
Pro Tyr Asn Gln Ser Tyr Asp Gln Asn Thr Gly Gly Ser Tyr Asn Ser
            1140                1145                1150
Ser Asp Arg Gly Ser Ser Thr Ser Gly Ser Gln Gly His Lys Lys Gly
        1155                1160                1165
Ala Arg Thr Pro Lys Val Pro Lys Gln Gly Gly Met Asn Trp Ala Asp
    1170                1175                1180
Leu Leu Pro Pro Pro Pro Ala His Pro Pro Pro His Ser Asn Ser Glu
1185                1190                1195                1200
Glu Tyr Asn Ile Ser Val Asp Glu Ser Tyr Asp Gln Glu Met Pro Cys
                1205                1210                1215
Pro Val Pro Pro Ala Arg Met Tyr Leu Gln Gln Asp Glu Leu Glu Glu
            1220                1225                1230
Glu Glu Asp Glu Arg Gly Pro Thr Pro Pro Val Arg Gly Ala Ala Ser
        1235                1240                1245
Ser Pro Ala Ala Val Ser Tyr Ser His Gln Ser Thr Ala Thr Leu Thr
    1250                1255                1260
Pro Ser Pro Gln Glu Glu Leu Gln Pro Met Leu Gln Asp Cys Pro Glu
1265                1270                1275                1280
Glu Thr Gly His Met Gln His Gln Pro Asp Arg Arg Arg Gln Pro Val
                1285                1290                1295
Ser Pro Pro Pro Pro Pro Arg Pro Ile Ser Pro Pro His Thr Tyr Gly
            1300                1305                1310
Tyr Ile Ser Gly Pro Leu Val Ser Asp Met Asp Thr Asp Ala Pro Glu
        1315                1320                1325
Glu Glu Glu Asp Glu Ala Asp Met Glu Val Ala Lys Met Gln Thr Arg
    1330                1335                1340
Arg Leu Leu Leu Arg Gly Leu Glu Gln Thr Pro Ala Ser Ser Val Gly
1345                1350                1355                1360
Asp Leu Glu Ser Ser Val Thr Gly Ser Met Ile Asn Gly Trp Gly Ser
                1365                1370                1375
Ala Ser Glu Glu Asp Asn Ile Ser Ser Gly Arg Ser Ser Val Ser Ser
            1380                1385                1390
Ser Asp Gly Ser Phe Phe Thr Asp Ala Asp Phe Ala Gln Ala Val Ala
        1395                1400                1405
Ala Ala Ala Glu Tyr Ala Gly Leu Lys Val Ala Arg Arg Gln Met Gln
    1410                1415                1420
Asp Ala Ala Gly Arg Arg His Phe His Ala Ser Gln Cys Pro Arg Pro
1425                1430                1435                1440
Thr Ser Pro Val Ser Thr Asp Ser Asn Met Ser Ala Ala Val Met Gln
                1445                1450                1455
Lys Thr Arg Pro Ala Lys Lys Leu Lys His Gln Pro Gly His Leu Arg
            1460                1465                1470
Arg Glu Thr Tyr Thr Asp Asp Leu Pro Pro Pro Pro Val Pro Pro Pro
        1475                1480                1485
Ala Ile Lys Ser Pro Thr Ala Gln Ser Lys Thr Gln Leu Glu Val Arg
    1490                1495                1500
Pro Val Val Val Pro Lys Leu Pro Ser Met Asp Ala Arg Thr Asp Arg
1505                1510                1515                1520
Ser Ser Asp Arg Lys Gly Ser Ser Tyr Lys Gly Arg Glu Val Leu Asp
                1525                1530                1535
Gly Arg Gln Val Val Asp Met Arg Thr Asn Pro Gly Asp Pro Arg Glu
            1540                1545                1550
Ala Gln Glu Gln Gln Asn Asp Gly Lys Gly Arg Gly Asn Lys Ala Ala
        1555                1560                1565
Lys Arg Asp Leu Pro Pro Ala Lys Thr His Leu Ile Gln Glu Asp Ile
    1570                1575                1580
Leu Pro Tyr Cys Arg Pro Thr Phe Pro Thr Ser Asn Asn Pro Arg Asp
1585                1590                1595                1600
Pro Ser Ser Ser Ser Ser Met Ser Ser Arg Gly Ser Gly Ser Arg Gln
                1605                1610                1615
Arg Glu Gln Ala Asn Val Gly Arg Arg Asn Ile Ala Glu Met Gln Val
            1620                1625                1630
Leu Gly Gly Tyr Glu Arg Gly Glu Asp Asn Asn Glu Glu Leu Glu Glu
        1635                1640                1645
Thr Glu Ser
    1650

<210> 756
<211> 753
<212> PRT
<213> Homo sapiens

<400> 756
Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu
 1               5                  10                  15
Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val
            20                  25                  30
Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu
        35                  40                  45
Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys
    50                  55                  60
Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg
65                  70                  75                  80
Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly
                85                  90                  95
Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn
            100                 105                 110
Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile
        115                 120                 125
Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val
    130                 135                 140
Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu
145                 150                 155                 160
Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp
                165                 170                 175
Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg
            180                 185                 190
Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly
        195                 200                 205
Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser
    210                 215                 220
Phe Val Lys Arg Pro Ser Asn Leu Ala Val Thr Val Asp Asp Ser Ala
225                 230                 235                 240
Glu Phe Lys Cys Glu Ala Arg Gly Asp Pro Val Pro Thr Val Arg Trp
                245                 250                 255
Arg Lys Asp Asp Gly Glu Leu Pro Lys Ser Arg Tyr Glu Ile Arg Asp
            260                 265                 270
Asp His Thr Leu Lys Ile Arg Lys Val Thr Ala Gly Asp Met Gly Ser
        275                 280                 285
Tyr Thr Cys Val Ala Glu Asn Met Val Gly Lys Ala Glu Ala Ser Ala
    290                 295                 300
Thr Leu Thr Val Gln Val Gly Ser Glu Pro Pro His Phe Val Val Lys
305                 310                 315                 320
Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val Thr Phe Gln Cys
                325                 330                 335
Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp Arg Arg Glu Gly
            340                 345                 350
Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln Ser Ser Ser Arg
        355                 360                 365
Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr Asn Val Gln Arg
    370                 375                 380
Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn Val Ala Gly Ser
385                 390                 395                 400
Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val Ile Ala Asp Arg
                405                 410                 415
Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln Thr Val Ala Val
            420                 425                 430
Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly Ser Pro Val Pro
        435                 440                 445
Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser Thr Gln Asp Ser
    450                 455                 460
Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile Arg Tyr Ala Lys
465                 470                 475                 480
Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser Thr Pro Ser Gly
                485                 490                 495
Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu Phe Gly Val Pro
            500                 505                 510
Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile Pro Ser Ala Pro
        515                 520                 525
Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr Val Thr Leu Ser
    530                 535                 540
Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr Ser Tyr Ile Ile
545                 550                 555                 560
Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln Thr Val Ala Glu
                565                 570                 575
Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu Lys Pro Asn Ala
            580                 585                 590
Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr Gly Ile Ser Asp
        595                 600                 605
Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp Val Leu Pro Thr
    610                 615                 620
Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu Leu Gly Asn Ala
625                 630                 635                 640
Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser Ser Ser Ile Glu
                645                 650                 655
Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile Gln Gly Tyr Lys
            660                 665                 670
Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu Ser Asp Trp Leu
        675                 680                 685
Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val Val Ile Pro Asp
    690                 695                 700
Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg Pro Phe Phe Asn
705                 710                 715                 720
Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala Lys Thr Leu Glu
                725                 730                 735
Glu Gly Lys Tyr Asp Glu Ala Phe Asp Phe His Ala Leu Gln Tyr Ile
            740                 745                 750
Cys


<210> 757
<211> 1649
<212> PRT
<213> Homo sapiens

<400> 757
Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser
 1               5                  10                  15
Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu
            20                  25                  30
Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp
        35                  40                  45
Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu
    50                  55                  60
Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser
65                  70                  75                  80
Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr
                85                  90                  95
Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys
            100                 105                 110
Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe
        115                 120                 125
Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val
    130                 135                 140
Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn
145                 150                 155                 160
Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro
                165                 170                 175
Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln
            180                 185                 190
Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly
        195                 200                 205
Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys
    210                 215                 220
Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys
225                 230                 235                 240
Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu
                245                 250                 255
Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala
            260                 265                 270
Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp
        275                 280                 285
Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys
    290                 295                 300
Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val
305                 310                 315                 320
Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val
                325                 330                 335
Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His
            340                 345                 350
Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val
        355                 360                 365
Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp
    370                 375                 380
Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln
385                 390                 395                 400
Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr
                405                 410                 415
Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn
            420                 425                 430
Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val
        435                 440                 445
Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln
    450                 455                 460
Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly
465                 470                 475                 480
Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser
                485                 490                 495
Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile
            500                 505                 510
Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser
        515                 520                 525
Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu
    530                 535                 540
Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile
545                 550                 555                 560
Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr
                565                 570                 575
Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr
            580                 585                 590
Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln
        595                 600                 605
Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu
    610                 615                 620
Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr
625                 630                 635                 640
Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp
                645                 650                 655
Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu
            660                 665                 670
Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser
        675                 680                 685
Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile
    690                 695                 700
Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu
705                 710                 715                 720
Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val
                725                 730                 735
Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg
            740                 745                 750
Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala
        755                 760                 765
Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val
    770                 775                 780
Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro
785                 790                 795                 800
Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp
                805                 810                 815
Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly
            820                 825                 830
Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr
        835                 840                 845
Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser
    850                 855                 860
Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro
865                 870                 875                 880
Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln
                885                 890                 895
Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met
            900                 905                 910
Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu
        915                 920                 925
Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr
    930                 935                 940
Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly
945                 950                 955                 960
Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu
                965                 970                 975
Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile
            980                 985                 990
Ser Cys Cys Thr Ala Gly Asn Gly Asn Ser Asp Ser Asn Leu Thr Thr
        995                 1000                1005
Tyr Ser Arg Pro Ala Asp Cys Ile Ala Asn Tyr Asn Asn Gln Leu Asp
    1010                1015                1020
Asn Lys Gln Thr Asn Leu Met Leu Pro Glu Ser Thr Val Tyr Gly Asp
1025                1030                1035                1040
Val Asp Leu Ser Asn Lys Ile Asn Glu Met Lys Thr Phe Asn Ser Pro
                1045                1050                1055
Asn Leu Lys Asp Gly Arg Phe Val Asn Pro Ser Gly Gln Pro Thr Pro
            1060                1065                1070
Tyr Ala Thr Thr Ile Gln Ser Asn Leu Ser Asn Asn Met Asn Asn Gly
        1075                1080                1085
Ser Gly Asp Ser Gly Glu Lys His Trp Lys Pro Leu Gly Gln Gln Lys
    1090                1095                1100
Gln Glu Val Ala Pro Val Gln Tyr Asn Ile Val Glu Gln Asn Lys Leu
1105                1110                1115                1120
Asn Lys Asp Tyr Arg Ala Asn Asp Thr Val Pro Pro Thr Ile Pro Tyr
                1125                1130                1135
Asn Gln Ser Tyr Asp Gln Asn Thr Gly Gly Ser Tyr Asn Ser Ser Asp
            1140                1145                1150
Arg Gly Ser Ser Thr Ser Gly Ser Gln Gly His Lys Lys Gly Ala Arg
        1155                1160                1165
Thr Pro Lys Val Pro Lys Gln Gly Gly Met Asn Trp Ala Asp Leu Leu
    1170                1175                1180
Pro Pro Pro Pro Ala His Pro Pro Pro His Ser Asn Ser Glu Glu Tyr
1185                1190                1195                1200
Asn Ile Ser Val Asp Glu Ser Tyr Asp Gln Glu Met Pro Cys Pro Val
                1205                1210                1215
Pro Pro Ala Arg Met Tyr Leu Gln Gln Asp Glu Leu Glu Glu Glu Glu
            1220                1225                1230
Asp Glu Arg Gly Pro Thr Pro Pro Val Arg Gly Ala Ala Ser Ser Pro
        1235                1240                1245
Ala Ala Val Ser Tyr Ser His Gln Ser Thr Ala Thr Leu Thr Pro Ser
    1250                1255                1260
Pro Gln Glu Glu Leu Gln Pro Met Leu Gln Asp Cys Pro Glu Glu Thr
1265                1270                1275                1280
Gly His Met Gln His Gln Pro Asp Arg Arg Arg Gln Pro Val Ser Pro
                1285                1290                1295
Pro Pro Pro Pro Arg Pro Ile Ser Pro Pro His Thr Tyr Gly Tyr Ile
            1300                1305                1310
Ser Gly Pro Leu Val Ser Asp Met Asp Thr Asp Ala Pro Glu Glu Glu
        1315                1320                1325
Glu Asp Glu Ala Asp Met Glu Val Ala Lys Met Gln Thr Arg Arg Leu
    1330                1335                1340
Leu Leu Arg Gly Leu Glu Gln Thr Pro Ala Ser Ser Val Gly Asp Leu
1345                1350                1355                1360
Glu Ser Ser Val Thr Gly Ser Met Ile Asn Gly Trp Gly Ser Ala Ser
                1365                1370                1375
Glu Glu Asp Asn Ile Ser Ser Gly Arg Ser Ser Val Ser Ser Ser Asp
            1380                1385                1390
Gly Ser Phe Phe Thr Asp Ala Asp Phe Ala Gln Ala Val Ala Ala Ala
        1395                1400                1405
Ala Glu Tyr Ala Gly Leu Lys Val Ala Arg Arg Gln Met Gln Asp Ala
    1410                1415                1420
Ala Gly Arg Arg His Phe His Ala Ser Gln Cys Pro Arg Pro Thr Ser
1425                1430                1435                1440
Pro Val Ser Thr Asp Ser Asn Met Ser Ala Ala Val Met Gln Lys Thr
                1445                1450                1455
Arg Pro Ala Lys Lys Leu Lys His Gln Pro Gly His Leu Arg Arg Glu
            1460                1465                1470
Thr Tyr Thr Asp Asp Leu Pro Pro Pro Pro Val Pro Pro Pro Ala Ile
        1475                1480                1485
Lys Ser Pro Thr Ala Gln Ser Lys Thr Gln Leu Glu Val Arg Pro Val
    1490                1495                1500
Val Val Pro Lys Leu Pro Ser Met Asp Ala Arg Thr Asp Arg Ser Ser
1505                1510                1515                1520
Asp Arg Lys Gly Ser Ser Tyr Lys Gly Arg Glu Val Leu Asp Gly Arg
                1525                1530                1535
Gln Val Val Asp Met Arg Thr Asn Pro Gly Asp Pro Arg Glu Ala Gln
            1540                1545                1550
Glu Gln Gln Asn Asp Gly Lys Gly Arg Gly Asn Lys Ala Ala Lys Arg
        1555                1560                1565
Asp Leu Pro Pro Ala Lys Thr His Leu Ile Gln Glu Asp Ile Leu Pro
    1570                1575                1580
Tyr Cys Arg Pro Thr Phe Pro Thr Ser Asn Asn Pro Arg Asp Pro Ser
1585                1590                1595                1600
Ser Ser Ser Ser Met Ser Ser Arg Gly Ser Gly Ser Arg Gln Arg Glu
                1605                1610                1615
Gln Ala Asn Val Gly Arg Arg Asn Ile Ala Glu Met Gln Val Leu Gly
            1620                1625                1630
Gly Tyr Glu Arg Gly Glu Asp Asn Asn Glu Glu Leu Glu Glu Thr Glu
        1635                1640                1645
Ser


<210> 758
<211> 1651
<212> PRT
<213> Homo sapiens

<400> 758
Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser
 1               5                  10                  15
Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu
            20                  25                  30
Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp
        35                  40                  45
Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu
    50                  55                  60
Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser
65                  70                  75                  80
Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr
                85                  90                  95
Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys
            100                 105                 110
Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe
        115                 120                 125
Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val
    130                 135                 140
Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn
145                 150                 155                 160
Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro
                165                 170                 175
Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln
            180                 185                 190
Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly
        195                 200                 205
Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys
    210                 215                 220
Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys
225                 230                 235                 240
Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu
                245                 250                 255
Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala
            260                 265                 270
Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp
        275                 280                 285
Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys
    290                 295                 300
Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val
305                 310                 315                 320
Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val
                325                 330                 335
Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His
            340                 345                 350
Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val
        355                 360                 365
Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp
    370                 375                 380
Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln
385                 390                 395                 400
Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr
                405                 410                 415
Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn
            420                 425                 430
Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val
        435                 440                 445
Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln
    450                 455                 460
Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly
465                 470                 475                 480
Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser
                485                 490                 495
Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile
            500                 505                 510
Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser
        515                 520                 525
Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu
    530                 535                 540
Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile
545                 550                 555                 560
Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr
                565                 570                 575
Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr
            580                 585                 590
Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln
        595                 600                 605
Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu
    610                 615                 620
Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr
625                 630                 635                 640
Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp
                645                 650                 655
Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu
            660                 665                 670
Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser
        675                 680                 685
Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile
    690                 695                 700
Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu
705                 710                 715                 720
Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val
                725                 730                 735
Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg
            740                 745                 750
Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala
        755                 760                 765
Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val
    770                 775                 780
Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro
785                 790                 795                 800
Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp
                805                 810                 815
Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly
            820                 825                 830
Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr
        835                 840                 845
Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser
    850                 855                 860
Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro
865                 870                 875                 880
Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln
                885                 890                 895
Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met
            900                 905                 910
Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu
        915                 920                 925
Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr
    930                 935                 940
Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly
945                 950                 955                 960
Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu
                965                 970                 975
Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile
            980                 985                 990
Ser Cys Cys Thr Ala Gly Asn Gly Asn Ser Asp Ser Asn Leu Thr Thr
        995                 1000                1005
Tyr Ser Arg Pro Ala Asp Cys Ile Ala Asn Tyr Asn Asn Gln Leu Asp
    1010                1015                1020
Asn Lys Gln Thr Asn Leu Met Leu Pro Glu Ser Thr Val Tyr Gly Asp
1025                1030                1035                1040
Val Asp Leu Ser Asn Lys Ile Asn Glu Met Lys Thr Phe Asn Ser Pro
                1045                1050                1055
Asn Leu Lys Asp Gly Arg Phe Val Asn Pro Ser Gly Gln Pro Thr Pro
            1060                1065                1070
Tyr Ala Thr Thr Gln Leu Ile Gln Ser Asn Leu Ser Asn Asn Met Asn
        1075                1080                1085
Asn Gly Ser Gly Asp Ser Gly Glu Lys His Trp Lys Pro Leu Gly Gln
    1090                1095                1100
Gln Lys Gln Glu Val Ala Pro Val Gln Tyr Asn Ile Val Glu Gln Asn
1105                1110                1115                1120
Lys Leu Asn Lys Asp Tyr Arg Ala Asn Asp Thr Val Pro Pro Thr Ile
                1125                1130                1135
Pro Tyr Asn Gln Ser Tyr Asp Gln Asn Thr Gly Gly Ser Tyr Asn Ser
            1140                1145                1150
Ser Asp Arg Gly Ser Ser Thr Ser Gly Ser Gln Gly His Lys Lys Gly
        1155                1160                1165
Ala Arg Thr Pro Lys Val Pro Lys Gln Gly Gly Met Asn Trp Ala Asp
    1170                1175                1180
Leu Leu Pro Pro Pro Pro Ala His Pro Pro Pro His Ser Asn Ser Glu
1185                1190                1195                1200
Glu Tyr Asn Ile Ser Val Asp Glu Ser Tyr Asp Gln Glu Met Pro Cys
                1205                1210                1215
Pro Val Pro Pro Ala Arg Met Tyr Leu Gln Gln Asp Glu Leu Glu Glu
            1220                1225                1230
Glu Glu Asp Glu Arg Gly Pro Thr Pro Pro Val Arg Gly Ala Ala Ser
        1235                1240                1245
Ser Pro Ala Ala Val Ser Tyr Ser His Gln Ser Thr Ala Thr Leu Thr
    1250                1255                1260
Pro Ser Pro Gln Glu Glu Leu Gln Pro Met Leu Gln Asp Cys Pro Glu
1265                1270                1275                1280
Glu Thr Gly His Met Gln His Gln Pro Asp Arg Arg Arg Gln Pro Val
                1285                1290                1295
Ser Pro Pro Pro Pro Pro Arg Pro Ile Ser Pro Pro His Thr Tyr Gly
            1300                1305                1310
Tyr Ile Ser Gly Pro Leu Val Ser Asp Met Asp Thr Asp Ala Pro Glu
        1315                1320                1325
Glu Glu Glu Asp Glu Ala Asp Met Glu Val Ala Lys Met Gln Thr Arg
    1330                1335                1340
Arg Leu Leu Leu Arg Gly Leu Glu Gln Thr Pro Ala Ser Ser Val Gly
1345                1350                1355                1360
Asp Leu Glu Ser Ser Val Thr Gly Ser Met Ile Asn Gly Trp Gly Ser
                1365                1370                1375
Ala Ser Glu Glu Asp Asn Ile Ser Ser Gly Arg Ser Ser Val Ser Ser
            1380                1385                1390
Ser Asp Gly Ser Phe Phe Thr Asp Ala Asp Phe Ala Gln Ala Val Ala
        1395                1400                1405
Ala Ala Ala Glu Tyr Ala Gly Leu Lys Val Ala Arg Arg Gln Met Gln
    1410                1415                1420
Asp Ala Ala Gly Arg Arg His Phe His Ala Ser Gln Cys Pro Arg Pro
1425                1430                1435                1440
Thr Ser Pro Val Ser Thr Asp Ser Asn Met Ser Ala Ala Val Met Gln
                1445                1450                1455
Lys Thr Arg Pro Ala Lys Lys Leu Lys His Gln Pro Gly His Leu Arg
            1460                1465                1470
Arg Glu Thr Tyr Thr Asp Asp Leu Pro Pro Pro Pro Val Pro Pro Pro
        1475                1480                1485
Ala Ile Lys Ser Pro Thr Ala Gln Ser Lys Thr Gln Leu Glu Val Arg
    1490                1495                1500
Pro Val Val Val Pro Lys Leu Pro Ser Met Asp Ala Arg Thr Asp Arg
1505                1510                1515                1520
Ser Ser Asp Arg Lys Gly Ser Ser Tyr Lys Gly Arg Glu Val Leu Asp
                1525                1530                1535
Gly Arg Gln Val Val Asp Met Arg Thr Asn Pro Gly Asp Pro Arg Glu
            1540                1545                1550
Ala Gln Glu Gln Gln Asn Asp Gly Lys Gly Arg Gly Asn Lys Ala Ala
        1555                1560                1565
Lys Arg Asp Leu Pro Pro Ala Lys Thr His Leu Ile Gln Glu Asp Ile
    1570                1575                1580
Leu Pro Tyr Cys Arg Pro Thr Phe Pro Thr Ser Asn Asn Pro Arg Asp
1585                1590                1595                1600
Pro Ser Ser Ser Ser Ser Met Ser Ser Arg Gly Ser Gly Ser Arg Gln
                1605                1610                1615
Arg Glu Gln Ala Asn Val Gly Arg Arg Asn Ile Ala Glu Met Gln Val
            1620                1625                1630
Leu Gly Gly Tyr Glu Arg Gly Glu Asp Asn Asn Glu Glu Leu Glu Glu
        1635                1640                1645
Thr Glu Ser
    1650

<210> 759
<211> 1651
<212> PRT
<213> Homo sapiens

<400> 759
Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser
 1               5                  10                  15
Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu
            20                  25                  30
Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp
        35                  40                  45
Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu
    50                  55                  60
Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser
65                  70                  75                  80
Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr
                85                  90                  95
Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys
            100                 105                 110
Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe
        115                 120                 125
Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val
    130                 135                 140
Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn
145                 150                 155                 160
Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro
                165                 170                 175
Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln
            180                 185                 190
Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly
        195                 200                 205
Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys
    210                 215                 220
Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys
225                 230                 235                 240
Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu
                245                 250                 255
Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala
            260                 265                 270
Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp
        275                 280                 285
Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys
    290                 295                 300
Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val
305                 310                 315                 320
Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val
                325                 330                 335
Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His
            340                 345                 350
Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val
        355                 360                 365
Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp
    370                 375                 380
Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln
385                 390                 395                 400
Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr
                405                 410                 415
Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn
            420                 425                 430
Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val
        435                 440                 445
Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln
    450                 455                 460
Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly
465                 470                 475                 480
Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser
                485                 490                 495
Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile
            500                 505                 510
Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser
        515                 520                 525
Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu
    530                 535                 540
Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile
545                 550                 555                 560
Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr
                565                 570                 575
Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr
            580                 585                 590
Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln
        595                 600                 605
Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu
    610                 615                 620
Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr
625                 630                 635                 640
Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp
                645                 650                 655
Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu
            660                 665                 670
Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser
        675                 680                 685
Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile
    690                 695                 700
Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu
705                 710                 715                 720
Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val
                725                 730                 735
Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg
            740                 745                 750
Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala
        755                 760                 765
Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val
    770                 775                 780
Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro
785                 790                 795                 800
Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp
                805                 810                 815
Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly
            820                 825                 830
Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr
        835                 840                 845
Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser
    850                 855                 860
Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro
865                 870                 875                 880
Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln
                885                 890                 895
Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met
            900                 905                 910
Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu
        915                 920                 925
Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr
    930                 935                 940
Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly
945                 950                 955                 960
Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu
                965                 970                 975
Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile
            980                 985                 990
Ser Cys Cys Thr Ala Gly Asn Gly Asn Ser Asp Ser Asn Leu Thr Thr
        995                 1000                1005
Tyr Ser Arg Pro Ala Asp Cys Ile Ala Asn Tyr Asn Asn Gln Leu Asp
    1010                1015                1020
Asn Lys Gln Thr Asn Leu Met Leu Pro Glu Ser Thr Val Tyr Gly Asp
1025                1030                1035                1040
Val Asp Leu Ser Asn Lys Ile Asn Glu Met Lys Thr Phe Asn Ser Pro
                1045                1050                1055
Asn Leu Lys Asp Gly Arg Phe Val Asn Pro Ser Gly Gln Pro Thr Pro
            1060                1065                1070
Tyr Ala Thr Thr Gln Leu Ile Gln Ser Asn Leu Ser Asn Asn Met Asn
        1075                1080                1085
Asn Gly Ser Gly Asp Ser Gly Glu Lys His Trp Lys Pro Leu Gly Gln
    1090                1095                1100
Gln Lys Gln Glu Val Ala Pro Val Gln Tyr Asn Ile Val Glu Gln Asn
1105                1110                1115                1120
Lys Leu Asn Lys Asp Tyr Arg Ala Asn Asp Thr Val Pro Pro Thr Ile
                1125                1130                1135
Pro Tyr Asn Gln Ser Tyr Asp Gln Asn Thr Gly Gly Ser Tyr Asn Ser
            1140                1145                1150
Ser Asp Arg Gly Ser Ser Thr Ser Gly Ser Gln Gly His Lys Lys Gly
        1155                1160                1165
Ala Arg Thr Pro Lys Val Pro Lys Gln Gly Gly Met Asn Trp Ala Asp
    1170                1175                1180
Leu Leu Pro Pro Pro Pro Ala His Pro Pro Pro His Ser Asn Ser Glu
1185                1190                1195                1200
Glu Tyr Asn Ile Ser Val Asp Glu Ser Tyr Asp Gln Glu Met Pro Cys
                1205                1210                1215
Pro Val Pro Pro Ala Arg Met Tyr Leu Gln Gln Asp Glu Leu Glu Glu
            1220                1225                1230
Glu Glu Asp Glu Arg Gly Pro Thr Pro Pro Val Arg Gly Ala Ala Ser
        1235                1240                1245
Ser Pro Ala Ala Val Ser Tyr Ser His Gln Ser Thr Ala Thr Leu Thr
    1250                1255                1260
Pro Ser Pro Gln Glu Glu Leu Gln Pro Met Leu Gln Asp Cys Pro Glu
1265                1270                1275                1280
Glu Thr Gly His Met Gln His Gln Pro Asp Arg Arg Arg Gln Pro Val
                1285                1290                1295
Ser Pro Pro Pro Pro Pro Arg Pro Ile Ser Pro Pro His Thr Tyr Gly
            1300                1305                1310
Tyr Ile Ser Gly Pro Leu Val Ser Asp Met Asp Thr Asp Ala Pro Glu
        1315                1320                1325
Glu Glu Glu Asp Glu Ala Asp Met Glu Val Ala Lys Met Gln Thr Arg
    1330                1335                1340
Arg Leu Leu Leu Arg Gly Leu Glu Gln Thr Pro Ala Ser Ser Val Gly
1345                1350                1355                1360
Asp Leu Glu Ser Ser Val Thr Gly Ser Met Ile Asn Gly Trp Gly Ser
                1365                1370                1375
Ala Ser Glu Glu Asp Asn Ile Ser Ser Gly Arg Ser Ser Val Ser Ser
            1380                1385                1390
Ser Asp Gly Ser Phe Phe Thr Asp Ala Asp Phe Ala Gln Ala Val Ala
        1395                1400                1405
Ala Ala Ala Glu Tyr Ala Gly Leu Lys Val Ala Arg Arg Gln Met Gln
    1410                1415                1420
Asp Ala Ala Gly Arg Arg His Phe His Ala Ser Gln Cys Pro Arg Pro
1425                1430                1435                1440
Thr Ser Pro Val Ser Thr Asp Ser Asn Met Ser Ala Ala Val Met Gln
                1445                1450                1455
Lys Thr Arg Pro Ala Lys Lys Leu Lys His Gln Pro Gly His Leu Arg
            1460                1465                1470
Arg Glu Thr Tyr Thr Asp Asp Leu Pro Pro Pro Pro Val Pro Pro Pro
        1475                1480                1485
Ala Ile Lys Ser Pro Thr Ala Gln Ser Lys Thr Gln Leu Glu Val Arg
    1490                1495                1500
Pro Val Val Val Pro Lys Leu Pro Ser Met Asp Ala Arg Thr Asp Arg
1505                1510                1515                1520
Ser Ser Asp Arg Lys Gly Ser Ser Tyr Lys Gly Arg Glu Val Leu Asp
                1525                1530                1535
Gly Arg Gln Val Val Asp Met Arg Thr Asn Pro Gly Asp Pro Arg Glu
            1540                1545                1550
Ala Gln Glu Gln Gln Asn Asp Gly Lys Gly Arg Gly Asn Lys Ala Ala
        1555                1560                1565
Lys Arg Asp Leu Pro Pro Ala Lys Thr His Leu Ile Gln Glu Asp Ile
    1570                1575                1580
Leu Pro Tyr Cys Arg Pro Thr Phe Pro Thr Ser Asn Asn Pro Arg Asp
1585                1590                1595                1600
Pro Ser Ser Ser Ser Ser Met Ser Ser Arg Gly Ser Gly Ser Arg Gln
                1605                1610                1615
Arg Glu Gln Ala Asn Val Gly Arg Arg Asn Ile Ala Glu Met Gln Val
            1620                1625                1630
Leu Gly Gly Tyr Glu Arg Gly Glu Asp Asn Asn Glu Glu Leu Glu Glu
        1635                1640                1645
Thr Glu Ser
    1650

<210> 760
<211> 1651
<212> PRT
<213> Homo sapiens

<400> 760
Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser
 1               5                  10                  15
Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu
            20                  25                  30
Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp
        35                  40                  45
Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu
    50                  55                  60
Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser
65                  70                  75                  80
Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr
                85                  90                  95
Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys
            100                 105                 110
Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe
        115                 120                 125
Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val
    130                 135                 140
Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn
145                 150                 155                 160
Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro
                165                 170                 175
Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln
            180                 185                 190
Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly
        195                 200                 205
Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys
    210                 215                 220
Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys
225                 230                 235                 240
Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu
                245                 250                 255
Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala
            260                 265                 270
Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp
        275                 280                 285
Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys
    290                 295                 300
Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val
305                 310                 315                 320
Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val
                325                 330                 335
Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His
            340                 345                 350
Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val
        355                 360                 365
Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp
    370                 375                 380
Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln
385                 390                 395                 400
Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr
                405                 410                 415
Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn
            420                 425                 430
Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val
        435                 440                 445
Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln
    450                 455                 460
Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly
465                 470                 475                 480
Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser
                485                 490                 495
Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile
            500                 505                 510
Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser
        515                 520                 525
Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu
    530                 535                 540
Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile
545                 550                 555                 560
Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr
                565                 570                 575
Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr
            580                 585                 590
Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln
        595                 600                 605
Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu
    610                 615                 620
Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr
625                 630                 635                 640
Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp
                645                 650                 655
Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu
            660                 665                 670
Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser
        675                 680                 685
Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile
    690                 695                 700
Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu
705                 710                 715                 720
Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val
                725                 730                 735
Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg
            740                 745                 750
Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala
        755                 760                 765
Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val
    770                 775                 780
Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro
785                 790                 795                 800
Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp
                805                 810                 815
Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly
            820                 825                 830
Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr
        835                 840                 845
Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser
    850                 855                 860
Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro
865                 870                 875                 880
Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln
                885                 890                 895
Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met
            900                 905                 910
Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu
        915                 920                 925
Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr
    930                 935                 940
Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly
945                 950                 955                 960
Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu
                965                 970                 975
Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile
            980                 985                 990
Ser Cys Cys Thr Ala Gly Asn Gly Asn Ser Asp Ser Asn Leu Thr Thr
        995                 1000                1005
Tyr Ser Arg Pro Ala Asp Cys Ile Ala Asn Tyr Asn Asn Gln Leu Asp
    1010                1015                1020
Asn Lys Gln Thr Asn Leu Met Leu Pro Glu Ser Thr Val Tyr Gly Asp
1025                1030                1035                1040
Val Asp Leu Ser Asn Lys Ile Asn Glu Met Lys Thr Phe Asn Ser Pro
                1045                1050                1055
Asn Leu Lys Asp Gly Arg Phe Val Asn Pro Ser Gly Gln Pro Thr Pro
            1060                1065                1070
Tyr Ala Thr Thr Gln Leu Ile Gln Ser Asn Leu Ser Asn Asn Met Asn
        1075                1080                1085
Asn Gly Ser Gly Asp Ser Gly Glu Lys His Trp Lys Pro Leu Gly Gln
    1090                1095                1100
Gln Lys Gln Glu Val Ala Pro Val Gln Tyr Asn Ile Val Glu Gln Asn
1105                1110                1115                1120
Lys Leu Asn Lys Asp Tyr Arg Ala Asn Asp Thr Val Pro Pro Thr Ile
                1125                1130                1135
Pro Tyr Asn Gln Ser Tyr Asp Gln Asn Thr Gly Gly Ser Tyr Asn Ser
            1140                1145                1150
Ser Asp Arg Gly Ser Ser Thr Ser Gly Ser Gln Gly His Lys Lys Gly
        1155                1160                1165
Ala Arg Thr Pro Lys Val Pro Lys Gln Gly Gly Met Asn Trp Ala Asp
    1170                1175                1180
Leu Leu Pro Pro Pro Pro Ala His Pro Pro Pro His Ser Asn Ser Glu
1185                1190                1195                1200
Glu Tyr Asn Ile Ser Val Asp Glu Ser Tyr Asp Gln Glu Met Pro Cys
                1205                1210                1215
Pro Val Pro Pro Ala Arg Met Tyr Leu Gln Gln Asp Glu Leu Glu Glu
            1220                1225                1230
Glu Glu Asp Glu Arg Gly Pro Thr Pro Pro Val Arg Gly Ala Ala Ser
        1235                1240                1245
Ser Pro Ala Ala Val Ser Tyr Ser His Gln Ser Thr Ala Thr Leu Thr
    1250                1255                1260
Pro Ser Pro Gln Glu Glu Leu Gln Pro Met Leu Gln Asp Cys Pro Glu
1265                1270                1275                1280
Glu Thr Gly His Met Gln His Gln Pro Asp Arg Arg Arg Gln Pro Val
                1285                1290                1295
Ser Pro Pro Pro Pro Pro Arg Pro Ile Ser Pro Pro His Thr Tyr Gly
            1300                1305                1310
Tyr Ile Ser Gly Pro Leu Val Ser Asp Met Asp Thr Asp Ala Pro Glu
        1315                1320                1325
Glu Glu Glu Asp Glu Ala Asp Met Glu Val Ala Lys Met Gln Thr Arg
    1330                1335                1340
Arg Leu Leu Leu Arg Gly Leu Glu Gln Thr Pro Ala Ser Ser Val Gly
1345                1350                1355                1360
Asp Leu Glu Ser Ser Val Thr Gly Ser Met Ile Asn Gly Trp Gly Ser
                1365                1370                1375
Ala Ser Glu Glu Asp Asn Ile Ser Ser Gly Arg Ser Ser Val Ser Ser
            1380                1385                1390
Ser Asp Gly Ser Phe Phe Thr Asp Ala Asp Phe Ala Gln Ala Val Ala
        1395                1400                1405
Ala Ala Ala Glu Tyr Ala Gly Leu Lys Val Ala Arg Arg Gln Met Gln
    1410                1415                1420
Asp Ala Ala Gly Arg Arg His Phe His Ala Ser Gln Cys Pro Arg Pro
1425                1430                1435                1440
Thr Ser Pro Val Ser Thr Asp Ser Asn Met Ser Ala Ala Val Met Gln
                1445                1450                1455
Lys Thr Arg Pro Ala Lys Lys Leu Lys His Gln Pro Gly His Leu Arg
            1460                1465                1470
Arg Glu Thr Tyr Thr Asp Asp Leu Pro Pro Pro Pro Val Pro Pro Pro
        1475                1480                1485
Ala Ile Lys Ser Pro Thr Ala Gln Ser Lys Thr Gln Leu Glu Val Arg
    1490                1495                1500
Pro Val Val Val Pro Lys Leu Pro Ser Met Asp Ala Arg Thr Asp Arg
1505                1510                1515                1520
Ser Ser Asp Arg Lys Gly Ser Ser Tyr Lys Gly Arg Glu Val Leu Asp
                1525                1530                1535
Gly Arg Gln Val Val Asp Met Arg Thr Asn Pro Gly Asp Pro Arg Glu
            1540                1545                1550
Ala Gln Glu Gln Gln Asn Asp Gly Lys Gly Arg Gly Asn Lys Ala Ala
        1555                1560                1565
Lys Arg Asp Leu Pro Pro Ala Lys Thr His Leu Ile Gln Glu Asp Ile
    1570                1575                1580
Leu Pro Tyr Cys Arg Pro Thr Phe Pro Thr Ser Asn Asn Pro Arg Asp
1585                1590                1595                1600
Pro Ser Ser Ser Ser Ser Met Ser Ser Arg Gly Ser Gly Ser Arg Gln
                1605                1610                1615
Arg Glu Gln Ala Asn Val Gly Arg Arg Asn Ile Ala Glu Met Gln Val
            1620                1625                1630
Leu Gly Gly Tyr Glu Arg Gly Glu Asp Asn Asn Glu Glu Leu Glu Glu
        1635                1640                1645
Thr Glu Ser
    1650

<210> 761
<211> 764
<212> PRT
<213> Homo sapiens

<400> 761
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 762
<211> 764
<212> PRT
<213> Homo sapiens

<400> 762
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 763
<211> 764
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(764)
<223> Xaa = Any Amino Acid

<400> 763
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Ser Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Val Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Asn Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Leu Phe Ile Trp Ile Ser
    450                 455                 460
Tyr Thr Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe His Ser Leu Leu
465                 470                 475                 480
Thr Val Val Ser Leu Val Leu Cys Phe Leu Val Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Met Val Arg Phe Leu Val Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Xaa Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 764
<211> 763
<212> PRT
<213> Homo sapiens

<400> 764
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu Leu
            420                 425                 430
Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val Gly
        435                 440                 445
Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser Phe
    450                 455                 460
Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu Thr
465                 470                 475                 480
Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu Pro
                485                 490                 495
Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr Tyr
            500                 505                 510
Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln Lys
        515                 520                 525
Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val Phe
    530                 535                 540
Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala Trp
545                 550                 555                 560
Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln Pro
                565                 570                 575
Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly Ile
            580                 585                 590
Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly Glu
        595                 600                 605
Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu Leu
    610                 615                 620
Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met Leu
625                 630                 635                 640
Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser Trp
                645                 650                 655
Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu Asn
            660                 665                 670
Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu Thr
        675                 680                 685
Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe Arg
    690                 695                 700
Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr Leu
705                 710                 715                 720
Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn Pro
                725                 730                 735
Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu Glu
            740                 745                 750
Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 765
<211> 764
<212> PRT
<213> Homo sapiens

<400> 765
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 766
<211> 764
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(764)
<223> Xaa = Any Amino Acid

<400> 766
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Xaa Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 767
<211> 764
<212> PRT
<213> Homo sapiens

<400> 767
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Ala Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 768
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(232)
<223> Xaa = Any Amino Acid

<400> 768
Met Ala Pro Pro Gly Trp Gln Xaa Xaa Xaa Xaa Xaa Trp Leu Ala Cys
 1               5                  10                  15
Pro Asp Arg Gly Glu Leu Ser Ser Arg Ser Pro Pro Cys Arg Leu Ala
            20                  25                  30
Arg Trp Ala Glu Gly Asp Arg Glu Thr Arg Thr Cys Leu Leu Glu Leu
        35                  40                  45
Ser Ala Gln Ser Trp Gly Gly Arg Phe Arg Arg Ser Ser Ala Val Ser
    50                  55                  60
Ala Gly Ser Pro Ser Arg Leu His Phe Leu Pro Gln Pro Leu Leu Leu
65                  70                  75                  80
Arg Ser Ser Gly Ile Pro Ala Ala Ala Thr Pro Trp Pro Gln Pro Ala
                85                  90                  95
Gly Leu Pro Val Arg Pro Thr Pro Thr Arg Thr Gly Glu Glu Asp Arg
            100                 105                 110
Thr Leu Asp Ile Ser Ile Cys Thr Glu Val Leu Ala Gly Thr Glu Gln
        115                 120                 125
Pro Pro Pro Pro Arg Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg
    130                 135                 140
Leu Glu Thr Leu Asp Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg
145                 150                 155                 160
Gly Lys Leu Asp Phe Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe
                165                 170                 175
Gln Gly Glu Asp Arg Lys Phe Ala Pro Ser Asp Lys Ser Gln Pro Pro
            180                 185                 190
Thr Thr Glu Arg Glu Gln Val Pro Val Ser Arg Ile Gln Thr Asp Leu
        195                 200                 205
Thr Glu Ile Gly Ser Ser Met Arg Ser Pro Gly Val Ser Pro Arg Ile
    210                 215                 220
Trp Leu Asp Phe Gln Ser Thr Xaa
225                 230

<210> 769
<211> 727
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(727)
<223> Xaa = Any Amino Acid

<400> 769
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Xaa Ile Phe Xaa Arg His Ile Leu Ala Ser Gly Lys Phe
305                 310                 315                 320
Ser Gly Leu Lys Pro Pro Phe Pro Arg Lys Phe Thr Glu Trp Trp Leu
                325                 330                 335
Met Gly Pro Val Arg Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            340                 345                 350
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        355                 360                 365
Pro Asp Arg His Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu
    370                 375                 380
Gln Ala Lys Trp Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu
385                 390                 395                 400
Cys Asn Leu Xaa Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln
                405                 410                 415
Pro Thr Leu Lys Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly
            420                 425                 430
Asn Ser Met Leu Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile
        435                 440                 445
Tyr Leu Leu Val Gly Gln Lys Trp Lys Phe Trp Xaa Xaa Xaa Xaa Xaa
    450                 455                 460
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Pro Gly His Arg Val
465                 470                 475                 480
Val Pro Ala Pro Ala Cys Val Cys Ala Gly Ala Gly Leu Ala Glu Pro
                485                 490                 495
Ala Leu Leu Tyr Thr Trp Leu Pro Ala His Arg His Leu Gln Cys His
            500                 505                 510
Asp Pro Glu Ala Leu Val Ser Leu Ser Gln Asp Trp Arg Pro Glu Ala
        515                 520                 525
Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln Pro Met Glu Gly Gln
    530                 535                 540
Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly Ile Leu Xaa Ala Ser
545                 550                 555                 560
Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly Glu Leu Ala Phe Gln
                565                 570                 575
Glu Gln Leu His Phe Arg Gly Met Val Leu Leu Leu Leu Leu Ala Tyr
            580                 585                 590
Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met Leu Ile Ala Leu Xaa
        595                 600                 605
Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser Trp Ser Ile Trp Lys
    610                 615                 620
Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu Asn Gly Tyr Trp Trp
625                 630                 635                 640
Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu Thr Val Gly Thr Lys
                645                 650                 655
Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe Arg Val Glu Glu Val
            660                 665                 670
Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr Leu Cys Glu Asp Pro
        675                 680                 685
Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn Pro Val Leu Ala Ser
    690                 695                 700
Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu Glu Asn Tyr Val Pro
705                 710                 715                 720
Val Gln Leu Leu Gln Ser Asn
                725

<210> 770
<211> 764
<212> PRT
<213> Homo sapiens

<400> 770
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 771
<211> 727
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(727)
<223> Xaa = Any Amino Acid

<400> 771
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Xaa Ile Phe Xaa Arg His Ile Leu Ala Ser Gly Lys Phe
305                 310                 315                 320
Ser Gly Leu Lys Pro Pro Phe Pro Arg Lys Phe Thr Glu Trp Trp Leu
                325                 330                 335
Met Gly Pro Val Arg Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            340                 345                 350
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        355                 360                 365
Pro Asp Arg His Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu
    370                 375                 380
Gln Ala Lys Trp Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu
385                 390                 395                 400
Cys Asn Leu Xaa Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln
                405                 410                 415
Pro Thr Leu Lys Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly
            420                 425                 430
Asn Ser Met Leu Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile
        435                 440                 445
Tyr Leu Leu Val Gly Gln Lys Trp Lys Phe Trp Xaa Xaa Xaa Xaa Xaa
    450                 455                 460
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Pro Gly His Arg Val
465                 470                 475                 480
Val Pro Ala Pro Ala Cys Val Cys Ala Gly Ala Gly Leu Ala Glu Pro
                485                 490                 495
Ala Leu Leu Tyr Thr Trp Leu Pro Ala His Arg His Leu Gln Cys His
            500                 505                 510
Asp Pro Glu Ala Leu Val Ser Leu Ser Gln Asp Trp Arg Pro Glu Ala
        515                 520                 525
Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln Pro Met Glu Gly Gln
    530                 535                 540
Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly Ile Leu Xaa Ala Ser
545                 550                 555                 560
Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly Glu Leu Ala Phe Gln
                565                 570                 575
Glu Gln Leu His Phe Arg Gly Met Val Leu Leu Leu Leu Leu Ala Tyr
            580                 585                 590
Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met Leu Ile Ala Leu Xaa
        595                 600                 605
Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser Trp Ser Ile Trp Lys
    610                 615                 620
Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu Asn Gly Tyr Trp Trp
625                 630                 635                 640
Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu Thr Val Gly Thr Lys
                645                 650                 655
Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe Arg Val Glu Glu Val
            660                 665                 670
Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr Leu Cys Glu Asp Pro
        675                 680                 685
Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn Pro Val Leu Ala Ser
    690                 695                 700
Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu Glu Asn Tyr Val Pro
705                 710                 715                 720
Val Gln Leu Leu Gln Ser Asn
                725

<210> 772
<211> 764
<212> PRT
<213> Homo sapiens

<400> 772
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 773
<211> 763
<212> PRT
<213> Homo sapiens

<400> 773
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu Leu
            420                 425                 430
Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val Gly
        435                 440                 445
Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser Phe
    450                 455                 460
Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu Thr
465                 470                 475                 480
Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu Pro
                485                 490                 495
Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr Tyr
            500                 505                 510
Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln Lys
        515                 520                 525
Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val Phe
    530                 535                 540
Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala Trp
545                 550                 555                 560
Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln Pro
                565                 570                 575
Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly Ile
            580                 585                 590
Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly Glu
        595                 600                 605
Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu Leu
    610                 615                 620
Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met Leu
625                 630                 635                 640
Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser Trp
                645                 650                 655
Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu Asn
            660                 665                 670
Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu Thr
        675                 680                 685
Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe Arg
    690                 695                 700
Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr Leu
705                 710                 715                 720
Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn Pro
                725                 730                 735
Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu Glu
            740                 745                 750
Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 774
<211> 763
<212> PRT
<213> Homo sapiens

<400> 774
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu Leu
            420                 425                 430
Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val Gly
        435                 440                 445
Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser Phe
    450                 455                 460
Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu Thr
465                 470                 475                 480
Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu Pro
                485                 490                 495
Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr Tyr
            500                 505                 510
Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln Lys
        515                 520                 525
Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val Phe
    530                 535                 540
Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala Trp
545                 550                 555                 560
Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln Pro
                565                 570                 575
Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly Ile
            580                 585                 590
Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly Glu
        595                 600                 605
Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu Leu
    610                 615                 620
Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met Leu
625                 630                 635                 640
Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser Trp
                645                 650                 655
Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu Asn
            660                 665                 670
Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu Thr
        675                 680                 685
Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe Arg
    690                 695                 700
Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr Leu
705                 710                 715                 720
Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn Pro
                725                 730                 735
Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu Glu
            740                 745                 750
Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 775
<211> 764
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(764)
<223> Xaa = Any Amino Acid

<400> 775
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Ser Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Val Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gly Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Leu Phe Ile Trp Ile Ser
    450                 455                 460
Tyr Thr Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe His Ser Leu Leu
465                 470                 475                 480
Thr Val Val Ser Leu Val Leu Cys Phe Leu Val Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Met Val Arg Phe Leu Val Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Thr
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Xaa Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 776
<211> 764
<212> PRT
<213> Homo sapiens

<400> 776
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 777
<211> 630
<212> PRT
<213> Homo sapiens

<400> 777
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Lys Ala Ile Ser Val Leu Glu Met Glu Asn Gly Tyr Trp Trp Cys
    530                 535                 540
Arg Lys Lys Gln Arg Ala Gly Val Met Leu Thr Val Gly Thr Lys Pro
545                 550                 555                 560
Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe Arg Val Glu Glu Val Asn
                565                 570                 575
Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr Leu Cys Glu Asp Pro Ser
            580                 585                 590
Gly Ala Gly Val Pro Arg Thr Leu Glu Asn Pro Val Leu Ala Ser Pro
        595                 600                 605
Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu Glu Asn Tyr Val Pro Val
    610                 615                 620
Gln Leu Leu Gln Ser Asn
625                 630

<210> 778
<211> 764
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(764)
<223> Xaa = Any Amino Acid

<400> 778
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Ser Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Val Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Asn Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Leu Phe Ile Trp Ile Ser
    450                 455                 460
Tyr Thr Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe His Ser Leu Leu
465                 470                 475                 480
Thr Val Val Ser Leu Val Leu Cys Phe Leu Val Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Met Val Arg Phe Leu Val Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Xaa Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 779
<211> 764
<212> PRT
<213> Homo sapiens

<400> 779
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser
    450                 455                 460
Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu
465                 470                 475                 480
Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 780
<211> 764
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(764)
<223> Xaa = Any Amino Acid

<400> 780
Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp
 1               5                  10                  15
Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe
            20                  25                  30
Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg
        35                  40                  45
Lys Phe Ala Ser Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr
    50                  55                  60
Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe
65                  70                  75                  80
Asn Val Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu
                85                  90                  95
Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu
            100                 105                 110
Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys
        115                 120                 125
Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp
    130                 135                 140
Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr
145                 150                 155                 160
Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu
                165                 170                 175
Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg
            180                 185                 190
Ala Cys Gly Arg Phe Phe Gln Asn Gly Gln Gly Thr Cys Phe Tyr Phe
        195                 200                 205
Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val
    210                 215                 220
Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala
225                 230                 235                 240
Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser
                245                 250                 255
Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly
            260                 265                 270
Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp
        275                 280                 285
Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu
    290                 295                 300
Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly
305                 310                 315                 320
Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val
                325                 330                 335
Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn
            340                 345                 350
Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His
        355                 360                 365
Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp
    370                 375                 380
Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile
385                 390                 395                 400
Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys
                405                 410                 415
Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu
            420                 425                 430
Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val
        435                 440                 445
Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Leu Phe Ile Trp Ile Ser
    450                 455                 460
Tyr Thr Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe His Ser Leu Leu
465                 470                 475                 480
Thr Val Val Ser Leu Val Leu Cys Phe Leu Val Ile Glu Trp Tyr Leu
                485                 490                 495
Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr
            500                 505                 510
Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln
        515                 520                 525
Lys Val Ile Leu Arg Asp Met Val Arg Phe Leu Val Ile Tyr Leu Val
    530                 535                 540
Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala
545                 550                 555                 560
Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln
                565                 570                 575
Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly
            580                 585                 590
Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly
        595                 600                 605
Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu
    610                 615                 620
Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met
625                 630                 635                 640
Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser
                645                 650                 655
Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Xaa Val Leu Glu Met Glu
            660                 665                 670
Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu
        675                 680                 685
Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe
    690                 695                 700
Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr
705                 710                 715                 720
Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn
                725                 730                 735
Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu
            740                 745                 750
Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn
        755                 760

<210> 781
<211> 835
<212> PRT
<213> Homo sapiens

<400> 781
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Thr Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys
        115                 120                 125
Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys
    130                 135                 140
Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp
145                 150                 155                 160
Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His
                165                 170                 175
Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp
            180                 185                 190
Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu
        195                 200                 205
Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr
    210                 215                 220
Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly
225                 230                 235                 240
Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys
                245                 250                 255
Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser
            260                 265                 270
Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp
        275                 280                 285
Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu
    290                 295                 300
Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro
305                 310                 315                 320
Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp
                325                 330                 335
Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr
            340                 345                 350
Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly
        355                 360                 365
Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn
    370                 375                 380
Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly
385                 390                 395                 400
Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu
                405                 410                 415
Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser
            420                 425                 430
Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile
        435                 440                 445
Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe
    450                 455                 460
Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro
465                 470                 475                 480
Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala
                485                 490                 495
Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly
            500                 505                 510
Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser
        515                 520                 525
His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp
    530                 535                 540
Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe
545                 550                 555                 560
Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln
                565                 570                 575
Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val
            580                 585                 590
Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val
        595                 600                 605
Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu
    610                 615                 620
Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu
625                 630                 635                 640
Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys
                645                 650                 655
Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala
            660                 665                 670
Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe
        675                 680                 685
Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile
    690                 695                 700
Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln
705                 710                 715                 720
Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg
                725                 730                 735
Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr
            740                 745                 750
Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr
        755                 760                 765
Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu
    770                 775                 780
Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp
785                 790                 795                 800
Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr
                805                 810                 815
Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu
            820                 825                 830
Ser Gly Ile
        835

<210> 782
<211> 835
<212> PRT
<213> Homo sapiens

<400> 782
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys
        115                 120                 125
Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys
    130                 135                 140
Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp
145                 150                 155                 160
Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His
                165                 170                 175
Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp
            180                 185                 190
Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu
        195                 200                 205
Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr
    210                 215                 220
Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly
225                 230                 235                 240
Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys
                245                 250                 255
Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser
            260                 265                 270
Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp
        275                 280                 285
Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu
    290                 295                 300
Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro
305                 310                 315                 320
Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp
                325                 330                 335
Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr
            340                 345                 350
Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly
        355                 360                 365
Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn
    370                 375                 380
Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly
385                 390                 395                 400
Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu
                405                 410                 415
Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser
            420                 425                 430
Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile
        435                 440                 445
Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe
    450                 455                 460
Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro
465                 470                 475                 480
Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala
                485                 490                 495
Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Val
            500                 505                 510
Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser
        515                 520                 525
His Leu Ser Ser Phe Thr Ile Leu Met Ala His Tyr Asp Val Glu Asp
    530                 535                 540
Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe
545                 550                 555                 560
Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln
                565                 570                 575
Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val
            580                 585                 590
Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val
        595                 600                 605
Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu
    610                 615                 620
Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu
625                 630                 635                 640
Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys
                645                 650                 655
Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala
            660                 665                 670
Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe
        675                 680                 685
Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile
    690                 695                 700
Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln
705                 710                 715                 720
Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg
                725                 730                 735
Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr
            740                 745                 750
Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr
        755                 760                 765
Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu
    770                 775                 780
Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp
785                 790                 795                 800
Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr
                805                 810                 815
Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu
            820                 825                 830
Ser Gly Ile
        835

<210> 783
<211> 742
<212> PRT
<213> Homo sapiens

<400> 783
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp
        115                 120                 125
Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys
    130                 135                 140
Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp
145                 150                 155                 160
Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly
                165                 170                 175
Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu
            180                 185                 190
Gly Arg Asp Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val
        195                 200                 205
Ile Lys Leu Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala
    210                 215                 220
Leu Ala Pro Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn
225                 230                 235                 240
Leu Glu Asp Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro
                245                 250                 255
Phe Thr Tyr Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln
            260                 265                 270
Glu Arg Gly Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met
        275                 280                 285
Lys Leu Asn Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala
    290                 295                 300
Val Ala Gly Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn
305                 310                 315                 320
Ala Ser Leu Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile
                325                 330                 335
Tyr Glu Ser Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val
            340                 345                 350
Asn Ser Ile Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro
        355                 360                 365
Ile Leu Phe Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly
    370                 375                 380
Arg Asp Pro Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu
385                 390                 395                 400
Leu Cys Ala Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala
                405                 410                 415
Thr Glu Val Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys
            420                 425                 430
Gln Cys Ser His Leu Ser Ser Phe Thr Ile Leu Met Ala His Tyr Asp
        435                 440                 445
Val Glu Asp Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu
    450                 455                 460
Ser Leu Phe Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg
465                 470                 475                 480
Pro Ile Gln Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys
                485                 490                 495
Leu Phe Val Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly
            500                 505                 510
Gly Gln Val Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr
        515                 520                 525
Cys Phe Leu Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu
    530                 535                 540
Tyr Phe Leu Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg
545                 550                 555                 560
Trp Leu Cys Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val
                565                 570                 575
Ser Ala Ala Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp
            580                 585                 590
Leu Asp Phe Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr
        595                 600                 605
Phe Ile Ile Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys
    610                 615                 620
Leu Thr Gln Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys
625                 630                 635                 640
Lys Ala Arg Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu
                645                 650                 655
Gly Cys Thr Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu
            660                 665                 670
Val Leu Thr Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe
        675                 680                 685
Leu Tyr Leu Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr
    690                 695                 700
Arg Lys Trp Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe
705                 710                 715                 720
Thr Ser Thr Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg
                725                 730                 735
Ala Ser Glu Ser Gly Ile
            740

<210> 784
<211> 831
<212> PRT
<213> Homo sapiens

<400> 784
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Thr Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys
        115                 120                 125
Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys
    130                 135                 140
Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp
145                 150                 155                 160
Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His
                165                 170                 175
Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp
            180                 185                 190
Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu
        195                 200                 205
Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr
    210                 215                 220
Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly
225                 230                 235                 240
Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys
                245                 250                 255
Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser
            260                 265                 270
Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp
        275                 280                 285
Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu
    290                 295                 300
Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro
305                 310                 315                 320
Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp
                325                 330                 335
Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr
            340                 345                 350
Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly
        355                 360                 365
Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn
    370                 375                 380
Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly
385                 390                 395                 400
Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu
                405                 410                 415
Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser
            420                 425                 430
Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile
        435                 440                 445
Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe
    450                 455                 460
Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro
465                 470                 475                 480
Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala
                485                 490                 495
Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly
            500                 505                 510
Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser
        515                 520                 525
His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp
    530                 535                 540
Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe
545                 550                 555                 560
Cys Leu Leu Leu Cys Ile Leu Thr Phe Pro Ile Gln Gly Ser Arg Thr
                565                 570                 575
Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val Gly Ser Thr Ile
            580                 585                 590
Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val Gly Leu Arg Cys
        595                 600                 605
Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu Ala Ala Phe Cys
    610                 615                 620
Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu Val Val Arg Val
625                 630                 635                 640
Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys Leu Ile Gly Tyr
                645                 650                 655
Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala Ile Tyr Ser Lys
            660                 665                 670
Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe Glu Gln Gly Phe
        675                 680                 685
Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile Leu Cys Asn Ala
    690                 695                 700
Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln Lys Phe Ser Glu
705                 710                 715                 720
Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg Ala Leu Thr Ile
                725                 730                 735
Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr Trp Val Phe Gly
            740                 745                 750
Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr Tyr Val Phe Thr
        755                 760                 765
Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu Leu His Cys Leu
    770                 775                 780
Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp Ala Cys Leu Val
785                 790                 795                 800
Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr Thr Ser Gly Thr
                805                 810                 815
Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu Ser Gly Ile
            820                 825                 830

<210> 785
<211> 835
<212> PRT
<213> Homo sapiens

<400> 785
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Thr Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys
        115                 120                 125
Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys
    130                 135                 140
Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp
145                 150                 155                 160
Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His
                165                 170                 175
Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp
            180                 185                 190
Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu
        195                 200                 205
Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr
    210                 215                 220
Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly
225                 230                 235                 240
Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys
                245                 250                 255
Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser
            260                 265                 270
Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp
        275                 280                 285
Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu
    290                 295                 300
Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro
305                 310                 315                 320
Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp
                325                 330                 335
Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr
            340                 345                 350
Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly
        355                 360                 365
Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn
    370                 375                 380
Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly
385                 390                 395                 400
Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu
                405                 410                 415
Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser
            420                 425                 430
Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile
        435                 440                 445
Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe
    450                 455                 460
Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro
465                 470                 475                 480
Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala
                485                 490                 495
Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly
            500                 505                 510
Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser
        515                 520                 525
His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp
    530                 535                 540
Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe
545                 550                 555                 560
Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln
                565                 570                 575
Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val
            580                 585                 590
Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val
        595                 600                 605
Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu
    610                 615                 620
Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu
625                 630                 635                 640
Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys
                645                 650                 655
Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala
            660                 665                 670
Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe
        675                 680                 685
Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile
    690                 695                 700
Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln
705                 710                 715                 720
Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg
                725                 730                 735
Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr
            740                 745                 750
Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr
        755                 760                 765
Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu
    770                 775                 780
Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp
785                 790                 795                 800
Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr
                805                 810                 815
Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu
            820                 825                 830
Ser Gly Ile
        835

<210> 786
<211> 835
<212> PRT
<213> Homo sapiens

<400> 786
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys
        115                 120                 125
Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys
    130                 135                 140
Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp
145                 150                 155                 160
Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His
                165                 170                 175
Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp
            180                 185                 190
Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu
        195                 200                 205
Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr
    210                 215                 220
Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly
225                 230                 235                 240
Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys
                245                 250                 255
Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser
            260                 265                 270
Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp
        275                 280                 285
Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu
    290                 295                 300
Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro
305                 310                 315                 320
Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp
                325                 330                 335
Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr
            340                 345                 350
Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly
        355                 360                 365
Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn
    370                 375                 380
Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly
385                 390                 395                 400
Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu
                405                 410                 415
Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser
            420                 425                 430
Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile
        435                 440                 445
Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe
    450                 455                 460
Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro
465                 470                 475                 480
Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala
                485                 490                 495
Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Val
            500                 505                 510
Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser
        515                 520                 525
His Leu Ser Ser Phe Thr Ile Leu Met Ala His Tyr Asp Val Glu Asp
    530                 535                 540
Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe
545                 550                 555                 560
Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln
                565                 570                 575
Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val
            580                 585                 590
Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val
        595                 600                 605
Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu
    610                 615                 620
Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu
625                 630                 635                 640
Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys
                645                 650                 655
Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala
            660                 665                 670
Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe
        675                 680                 685
Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile
    690                 695                 700
Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln
705                 710                 715                 720
Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg
                725                 730                 735
Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr
            740                 745                 750
Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr
        755                 760                 765
Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu
    770                 775                 780
Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp
785                 790                 795                 800
Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr
                805                 810                 815
Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu
            820                 825                 830
Ser Gly Ile
        835

<210> 787
<211> 835
<212> PRT
<213> Homo sapiens

<400> 787
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Thr Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys
        115                 120                 125
Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys
    130                 135                 140
Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp
145                 150                 155                 160
Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His
                165                 170                 175
Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp
            180                 185                 190
Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu
        195                 200                 205
Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr
    210                 215                 220
Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly
225                 230                 235                 240
Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys
                245                 250                 255
Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser
            260                 265                 270
Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp
        275                 280                 285
Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu
    290                 295                 300
Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro
305                 310                 315                 320
Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp
                325                 330                 335
Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr
            340                 345                 350
Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly
        355                 360                 365
Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn
    370                 375                 380
Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly
385                 390                 395                 400
Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu
                405                 410                 415
Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser
            420                 425                 430
Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile
        435                 440                 445
Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe
    450                 455                 460
Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro
465                 470                 475                 480
Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala
                485                 490                 495
Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly
            500                 505                 510
Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser
        515                 520                 525
His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp
    530                 535                 540
Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe
545                 550                 555                 560
Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln
                565                 570                 575
Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val
            580                 585                 590
Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val
        595                 600                 605
Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu
    610                 615                 620
Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu
625                 630                 635                 640
Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys
                645                 650                 655
Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala
            660                 665                 670
Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe
        675                 680                 685
Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile
    690                 695                 700
Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln
705                 710                 715                 720
Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg
                725                 730                 735
Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr
            740                 745                 750
Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr
        755                 760                 765
Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu
    770                 775                 780
Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp
785                 790                 795                 800
Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr
                805                 810                 815
Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu
            820                 825                 830
Ser Gly Ile
        835

<210> 788
<211> 835
<212> PRT
<213> Homo sapiens

<400> 788
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Thr Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys
        115                 120                 125
Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys
    130                 135                 140
Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp
145                 150                 155                 160
Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His
                165                 170                 175
Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp
            180                 185                 190
Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu
        195                 200                 205
Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr
    210                 215                 220
Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly
225                 230                 235                 240
Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys
                245                 250                 255
Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser
            260                 265                 270
Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp
        275                 280                 285
Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu
    290                 295                 300
Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro
305                 310                 315                 320
Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp
                325                 330                 335
Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr
            340                 345                 350
Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly
        355                 360                 365
Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn
    370                 375                 380
Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly
385                 390                 395                 400
Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu
                405                 410                 415
Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser
            420                 425                 430
Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile
        435                 440                 445
Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe
    450                 455                 460
Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro
465                 470                 475                 480
Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala
                485                 490                 495
Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly
            500                 505                 510
Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser
        515                 520                 525
His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp
    530                 535                 540
Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe
545                 550                 555                 560
Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln
                565                 570                 575
Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val
            580                 585                 590
Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val
        595                 600                 605
Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu
    610                 615                 620
Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu
625                 630                 635                 640
Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys
                645                 650                 655
Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala
            660                 665                 670
Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe
        675                 680                 685
Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile
    690                 695                 700
Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln
705                 710                 715                 720
Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg
                725                 730                 735
Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr
            740                 745                 750
Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr
        755                 760                 765
Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu
    770                 775                 780
Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp
785                 790                 795                 800
Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr
                805                 810                 815
Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu
            820                 825                 830
Ser Gly Ile
        835

<210> 789
<211> 742
<212> PRT
<213> Homo sapiens

<400> 789
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp
        115                 120                 125
Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys
    130                 135                 140
Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp
145                 150                 155                 160
Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly
                165                 170                 175
Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu
            180                 185                 190
Gly Arg Asp Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val
        195                 200                 205
Ile Lys Leu Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala
    210                 215                 220
Leu Ala Pro Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn
225                 230                 235                 240
Leu Glu Asp Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro
                245                 250                 255
Phe Thr Tyr Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln
            260                 265                 270
Glu Arg Gly Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met
        275                 280                 285
Lys Leu Asn Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala
    290                 295                 300
Val Ala Gly Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn
305                 310                 315                 320
Ala Ser Leu Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile
                325                 330                 335
Tyr Glu Ser Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val
            340                 345                 350
Asn Ser Ile Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro
        355                 360                 365
Ile Leu Phe Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly
    370                 375                 380
Arg Asp Pro Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu
385                 390                 395                 400
Leu Cys Ala Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala
                405                 410                 415
Thr Glu Val Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys
            420                 425                 430
Gln Cys Ser His Leu Ser Ser Phe Thr Ile Leu Met Ala His Tyr Asp
        435                 440                 445
Val Glu Asp Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu
    450                 455                 460
Ser Leu Phe Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg
465                 470                 475                 480
Pro Ile Gln Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys
                485                 490                 495
Leu Phe Val Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly
            500                 505                 510
Gly Gln Val Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr
        515                 520                 525
Cys Phe Leu Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu
    530                 535                 540
Tyr Phe Leu Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg
545                 550                 555                 560
Trp Leu Cys Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val
                565                 570                 575
Ser Ala Ala Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp
            580                 585                 590
Leu Asp Phe Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr
        595                 600                 605
Phe Ile Ile Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys
    610                 615                 620
Leu Thr Gln Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys
625                 630                 635                 640
Lys Ala Arg Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu
                645                 650                 655
Gly Cys Thr Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu
            660                 665                 670
Val Leu Thr Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe
        675                 680                 685
Leu Tyr Leu Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr
    690                 695                 700
Arg Lys Trp Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe
705                 710                 715                 720
Thr Ser Thr Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg
                725                 730                 735
Ala Ser Glu Ser Gly Ile
            740

<210> 790
<211> 835
<212> PRT
<213> Homo sapiens

<400> 790
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys
        115                 120                 125
Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys
    130                 135                 140
Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp
145                 150                 155                 160
Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His
                165                 170                 175
Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp
            180                 185                 190
Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu
        195                 200                 205
Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr
    210                 215                 220
Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly
225                 230                 235                 240
Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys
                245                 250                 255
Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser
            260                 265                 270
Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp
        275                 280                 285
Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu
    290                 295                 300
Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro
305                 310                 315                 320
Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp
                325                 330                 335
Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr
            340                 345                 350
Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly
        355                 360                 365
Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn
    370                 375                 380
Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly
385                 390                 395                 400
Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu
                405                 410                 415
Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser
            420                 425                 430
Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile
        435                 440                 445
Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe
    450                 455                 460
Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro
465                 470                 475                 480
Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala
                485                 490                 495
Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Val
            500                 505                 510
Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser
        515                 520                 525
His Leu Ser Ser Phe Thr Ile Leu Met Ala His Tyr Asp Val Glu Asp
    530                 535                 540
Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe
545                 550                 555                 560
Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln
                565                 570                 575
Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val
            580                 585                 590
Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val
        595                 600                 605
Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu
    610                 615                 620
Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu
625                 630                 635                 640
Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys
                645                 650                 655
Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala
            660                 665                 670
Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe
        675                 680                 685
Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile
    690                 695                 700
Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln
705                 710                 715                 720
Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg
                725                 730                 735
Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr
            740                 745                 750
Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr
        755                 760                 765
Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu
    770                 775                 780
Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp
785                 790                 795                 800
Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr
                805                 810                 815
Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu
            820                 825                 830
Ser Gly Ile
        835

<210> 791
<211> 835
<212> PRT
<213> Homo sapiens

<400> 791
Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro
 1               5                  10                  15
Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln
            20                  25                  30
Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe
        35                  40                  45
Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp
    50                  55                  60
Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser
65                  70                  75                  80
Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly
                85                  90                  95
Tyr Glu Pro Val Ser Gly Thr Lys Thr Phe Lys Asn Glu Ser Glu Asn
            100                 105                 110
Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys
        115                 120                 125
Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys
    130                 135                 140
Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp
145                 150                 155                 160
Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His
                165                 170                 175
Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp
            180                 185                 190
Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu
        195                 200                 205
Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr
    210                 215                 220
Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly
225                 230                 235                 240
Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys
                245                 250                 255
Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser
            260                 265                 270
Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp
        275                 280                 285
Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu
    290                 295                 300
Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro
305                 310                 315                 320
Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp
                325                 330                 335
Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr
            340                 345                 350
Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly
        355                 360                 365
Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn
    370                 375                 380
Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly
385                 390                 395                 400
Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu
                405                 410                 415
Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser
            420                 425                 430
Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile
        435                 440                 445
Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe
    450                 455                 460
Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro
465                 470                 475                 480
Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala
                485                 490                 495
Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly
            500                 505                 510
Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser
        515                 520                 525
His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp
    530                 535                 540
Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe
545                 550                 555                 560
Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln
                565                 570                 575
Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val
            580                 585                 590
Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val
        595                 600                 605
Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu
    610                 615                 620
Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu
625                 630                 635                 640
Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys
                645                 650                 655
Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala
            660                 665                 670
Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe
        675                 680                 685
Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile
    690                 695                 700
Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln
705                 710                 715                 720
Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg
                725                 730                 735
Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr
            740                 745                 750
Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr
        755                 760                 765
Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu
    770                 775                 780
Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp
785                 790                 795                 800
Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr
                805                 810                 815
Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu
            820                 825                 830
Ser Gly Ile
        835

<210> 792
<211> 860
<212> PRT
<213> Homo sapiens

<400> 792
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860

<210> 793
<211> 860
<212> PRT
<213> Homo sapiens

<400> 793
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860

<210> 794
<211> 837
<212> PRT
<213> Homo sapiens

<400> 794
Gly Asp Arg Cys Glu Arg Asn Glu Phe Gln Cys Gln Asp Gly Lys Cys
 1               5                  10                  15
Ile Ser Tyr Lys Trp Val Cys Asp Gly Ser Ala Glu Cys Gln Asp Gly
            20                  25                  30
Ser Asp Glu Ser Gln Glu Thr Cys Leu Ser Val Thr Cys Lys Ser Gly
        35                  40                  45
Asp Phe Ser Cys Gly Gly Arg Val Asn Arg Cys Ile Pro Gln Phe Trp
    50                  55                  60
Arg Cys Asp Gly Gln Val Asp Cys Asp Asn Gly Ser Asp Glu Gln Gly
65                  70                  75                  80
Cys Pro Pro Lys Thr Cys Ser Gln Asp Glu Phe Arg Cys His Asp Gly
                85                  90                  95
Lys Cys Ile Ser Arg Gln Phe Val Cys Asp Ser Asp Arg Asp Cys Leu
            100                 105                 110
Asp Gly Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys Gly Pro Ala
        115                 120                 125
Ser Phe Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp Ala Cys
    130                 135                 140
Asp Asn Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro Gln Arg
145                 150                 155                 160
Cys Arg Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys Ser Ala
                165                 170                 175
Phe Glu Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser Trp Arg
            180                 185                 190
Cys Asp Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu Asn Cys
        195                 200                 205
Ala Val Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp Gly Asn
    210                 215                 220
Cys Ile His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp
225                 230                 235                 240
Met Ser Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro
                245                 250                 255
Asn Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val
            260                 265                 270
Cys Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys
        275                 280                 285
Glu Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His
    290                 295                 300
Val Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly
305                 310                 315                 320
Phe Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln
                325                 330                 335
Asp Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr
            340                 345                 350
Lys Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala
        355                 360                 365
Cys Lys Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His
    370                 375                 380
Glu Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile
385                 390                 395                 400
Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn
                405                 410                 415
Arg Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln
            420                 425                 430
Leu Asp Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg
        435                 440                 445
Asp Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn
    450                 455                 460
Ile Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr
465                 470                 475                 480
Lys Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro
                485                 490                 495
Arg Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp
            500                 505                 510
Trp Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp
        515                 520                 525
Ile Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr
    530                 535                 540
Leu Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His
545                 550                 555                 560
Ser Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu
                565                 570                 575
Glu Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu
            580                 585                 590
Asp Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala
        595                 600                 605
Asn Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu
    610                 615                 620
Ser Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly
625                 630                 635                 640
Val Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr
                645                 650                 655
Leu Cys Leu Pro Ala Ser Gln Ile Asn Pro His Ser Pro Lys Phe Thr
            660                 665                 670
Cys Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys
        675                 680                 685
Leu Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val
    690                 695                 700
Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr
705                 710                 715                 720
Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu
                725                 730                 735
Thr Thr Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val
            740                 745                 750
Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser
        755                 760                 765
Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe
    770                 775                 780
Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe
785                 790                 795                 800
Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys
                805                 810                 815
His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu
            820                 825                 830
Glu Asp Asp Val Ala
        835

<210> 795
<211> 839
<212> PRT
<213> Homo sapiens

<400> 795
Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe Gln Cys Gln Asp Gly
 1               5                  10                  15
Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly Ser Ala Glu Cys Gln
            20                  25                  30
Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu Ser Val Thr Cys Lys
        35                  40                  45
Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn Arg Cys Ile Pro Gln
    50                  55                  60
Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp Asn Gly Ser Asp Glu
65                  70                  75                  80
Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp Glu Phe Arg Cys His
                85                  90                  95
Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys Asp Ser Asp Arg Asp
            100                 105                 110
Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys Gly
        115                 120                 125
Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp
    130                 135                 140
Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro
145                 150                 155                 160
Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys
                165                 170                 175
Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser
            180                 185                 190
Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu
        195                 200                 205
Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp
    210                 215                 220
Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys
225                 230                 235                 240
Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu
                245                 250                 255
Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp
            260                 265                 270
Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro
        275                 280                 285
Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys
    290                 295                 300
Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro
305                 310                 315                 320
Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu
                325                 330                 335
Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly
            340                 345                 350
Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr
        355                 360                 365
Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn
    370                 375                 380
Arg His Glu Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser
385                 390                 395                 400
Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala
                405                 410                 415
Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser
            420                 425                 430
Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile
        435                 440                 445
Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His
    450                 455                 460
Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala
465                 470                 475                 480
Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser
                485                 490                 495
Lys Pro Arg Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp
            500                 505                 510
Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly
        515                 520                 525
Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly
    530                 535                 540
Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys
545                 550                 555                 560
Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr
                565                 570                 575
Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val
            580                 585                 590
Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe
        595                 600                 605
Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn
    610                 615                 620
Leu Leu Ser Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro
625                 630                 635                 640
Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys
                645                 650                 655
Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys
            660                 665                 670
Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg
        675                 680                 685
Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser
    690                 695                 700
Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr
705                 710                 715                 720
Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro
                725                 730                 735
Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly
            740                 745                 750
Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala
        755                 760                 765
Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly
    770                 775                 780
Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile
785                 790                 795                 800
Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His
                805                 810                 815
Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val
            820                 825                 830
Ser Leu Glu Asp Asp Val Ala
        835

<210> 796
<211> 860
<212> PRT
<213> Homo sapiens

<400> 796
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860

<210> 797
<211> 839
<212> PRT
<213> Homo sapiens

<400> 797
Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe Gln Cys Gln Asp Gly
 1               5                  10                  15
Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly Ser Ala Glu Cys Gln
            20                  25                  30
Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu Ser Val Thr Cys Lys
        35                  40                  45
Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn Arg Cys Ile Pro Gln
    50                  55                  60
Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp Asn Gly Ser Asp Glu
65                  70                  75                  80
Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp Glu Phe Arg Cys His
                85                  90                  95
Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys Asp Ser Asp Arg Asp
            100                 105                 110
Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys Gly
        115                 120                 125
Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp
    130                 135                 140
Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro
145                 150                 155                 160
Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys
                165                 170                 175
Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser
            180                 185                 190
Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu
        195                 200                 205
Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp
    210                 215                 220
Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys
225                 230                 235                 240
Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu
                245                 250                 255
Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp
            260                 265                 270
Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro
        275                 280                 285
Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys
    290                 295                 300
Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro
305                 310                 315                 320
Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu
                325                 330                 335
Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly
            340                 345                 350
Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr
        355                 360                 365
Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn
    370                 375                 380
Arg His Glu Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser
385                 390                 395                 400
Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala
                405                 410                 415
Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser
            420                 425                 430
Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile
        435                 440                 445
Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His
    450                 455                 460
Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala
465                 470                 475                 480
Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser
                485                 490                 495
Lys Pro Arg Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp
            500                 505                 510
Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly
        515                 520                 525
Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly
    530                 535                 540
Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys
545                 550                 555                 560
Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr
                565                 570                 575
Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val
            580                 585                 590
Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe
        595                 600                 605
Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn
    610                 615                 620
Leu Leu Ser Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro
625                 630                 635                 640
Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys
                645                 650                 655
Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys
            660                 665                 670
Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg
        675                 680                 685
Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser
    690                 695                 700
Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr
705                 710                 715                 720
Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro
                725                 730                 735
Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly
            740                 745                 750
Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala
        755                 760                 765
Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly
    770                 775                 780
Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile
785                 790                 795                 800
Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His
                805                 810                 815
Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val
            820                 825                 830
Ser Leu Glu Asp Asp Val Ala
        835

<210> 798
<211> 729
<212> PRT
<213> Homo sapiens

<400> 798
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Gly His Glu Glu Leu Pro His Arg Gly Leu Arg Leu Gln Trp
705                 710                 715                 720
Pro Pro Arg Arg His Pro Pro Ser Gly
                725

<210> 799
<211> 670
<212> PRT
<213> Homo sapiens

<400> 799
Phe Arg Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser
 1               5                  10                  15
Gly Glu Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys
            20                  25                  30
Lys Asp Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro
        35                  40                  45
Asp Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln
    50                  55                  60
Cys Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys
65                  70                  75                  80
Val Asn Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser
                85                  90                  95
Gly Glu Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys
            100                 105                 110
Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys
        115                 120                 125
Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile
    130                 135                 140
Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg
145                 150                 155                 160
Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln
                165                 170                 175
Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly
            180                 185                 190
Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile
        195                 200                 205
Ala Tyr Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu
    210                 215                 220
Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val
225                 230                 235                 240
Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu
                245                 250                 255
Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val
            260                 265                 270
Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly
        275                 280                 285
Leu Ala Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val
    290                 295                 300
Leu Gly Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr
305                 310                 315                 320
Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro
                325                 330                 335
Val His Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile
            340                 345                 350
Lys Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu
        355                 360                 365
Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg
    370                 375                 380
Leu Tyr Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val
385                 390                 395                 400
Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala
                405                 410                 415
His Pro Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp
            420                 425                 430
Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp
        435                 440                 445
Val Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu
    450                 455                 460
Phe His Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr
465                 470                 475                 480
Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln
                485                 490                 495
Ile Asn Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met
            500                 505                 510
Leu Leu Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Gly Glu Ala Ala
        515                 520                 525
Val Ala Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr
    530                 535                 540
Ala Val Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser
545                 550                 555                 560
Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr
                565                 570                 575
Met Ser His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys
            580                 585                 590
Lys Pro Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu
        595                 600                 605
Leu Val Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg
    610                 615                 620
Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys
625                 630                 635                 640
Thr Thr Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser
                645                 650                 655
Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
            660                 665                 670

<210> 800
<211> 800
<212> PRT
<213> Homo sapiens

<400> 800
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Phe Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Val Ala Thr Cys
                165                 170                 175
Arg Pro Asp Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser
            180                 185                 190
Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val
        195                 200                 205
Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys
    210                 215                 220
His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg
225                 230                 235                 240
Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn
                245                 250                 255
Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu
            260                 265                 270
Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala
        275                 280                 285
Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys
    290                 295                 300
Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu
305                 310                 315                 320
Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly
                325                 330                 335
Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met
            340                 345                 350
Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn
        355                 360                 365
Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser
    370                 375                 380
Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His
385                 390                 395                 400
Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro
                405                 410                 415
Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp
            420                 425                 430
Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg
        435                 440                 445
Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val
    450                 455                 460
Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala
465                 470                 475                 480
Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val
                485                 490                 495
Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser
            500                 505                 510
Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile
        515                 520                 525
Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg
    530                 535                 540
Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp
545                 550                 555                 560
Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly
                565                 570                 575
Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met
            580                 585                 590
Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu
        595                 600                 605
Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala
    610                 615                 620
Pro Gln Ile Asn Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp
625                 630                 635                 640
Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu
                645                 650                 655
Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser
            660                 665                 670
Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp
        675                 680                 685
Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile
    690                 695                 700
Val Thr Met Ser His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn
705                 710                 715                 720
Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile
                725                 730                 735
Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn
            740                 745                 750
Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr
        755                 760                 765
Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly
    770                 775                 780
Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
785                 790                 795                 800

<210> 801
<211> 860
<212> PRT
<213> Homo sapiens

<400> 801
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Gly Asp Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860

<210> 802
<211> 750
<212> PRT
<213> Homo sapiens

<400> 802
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser
            740                 745                 750

<210> 803
<211> 860
<212> PRT
<213> Homo sapiens

<400> 803
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860

<210> 804
<211> 1418
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(1418)
<223> Xaa = Any Amino Acid

<400> 804
Met Gly Pro Trp Ala Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Val Pro Asp Lys Thr
                725                 730                 735
Val Arg Trp Cys Ala Val Ser Glu His Glu Ala Thr Lys Cys Gln Ser
            740                 745                 750
Phe Arg Asp His Met Lys Ser Val Ile Pro Ser Asp Gly Pro Ser Val
        755                 760                 765
Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys Ile Arg Ala Ile Ala
    770                 775                 780
Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala Gly Leu Val Tyr Asp
785                 790                 795                 800
Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val Val Ala Glu Phe Tyr
                805                 810                 815
Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr Ala Val Ala Val Val
            820                 825                 830
Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu Arg Gly Lys Lys Ser
        835                 840                 845
Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp Asn Ile Pro Ile Gly
    850                 855                 860
Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys Pro Leu Glu Lys Ala
865                 870                 875                 880
Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro Cys Ala Asp Gly Thr
                885                 890                 895
Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly Cys Gly Cys Ser Thr
            900                 905                 910
Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Lys Asp
        915                 920                 925
Gly Ala Gly Asp Val Ala Phe Val Lys His Ser Thr Ile Phe Glu Asn
    930                 935                 940
Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu Leu Leu Cys Leu Asp
945                 950                 955                 960
Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp Cys His Leu Ala Gln
                965                 970                 975
Val Pro Ser His Thr Val Val Ala Arg Ser Met Gly Gly Lys Glu Asp
            980                 985                 990
Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu His Phe Gly Lys Asp
        995                 1000                1005
Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro His Gly Lys Asp Leu
    1010                1015                1020
Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys Val Pro Gln Arg Met
1025                1030                1035                1040
Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val Thr Ala Ile Arg Asn
                1045                1050                1055
Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr Asp Glu Cys Lys Pro
            1060                1065                1070
Val Lys Trp Cys Ala Leu Ser His His Glu Arg Leu Lys Cys Asp Glu
        1075                1080                1085
Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys Val Ser Ala Glu Thr
    1090                1095                1100
Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly Glu Ala Asp Ala Met
1105                1110                1115                1120
Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly Lys Cys Gly Leu Val
                1125                1130                1135
Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp Asn Cys Glu Asp Thr
            1140                1145                1150
Pro Glu Ala Gly Tyr Phe Ala Val Ala Val Val Lys Lys Ser Ala Ser
        1155                1160                1165
Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys Ser Cys His Thr Ala
    1170                1175                1180
Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Tyr Asn
1185                1190                1195                1200
Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe Ser Glu Gly Cys Ala
                1205                1210                1215
Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys Leu Cys Met Gly Ser
            1220                1225                1230
Gly Leu Asn Leu Cys Glu Pro Asn Asn Lys Arg Gly Asp Thr Thr Gly
        1235                1240                1245
Tyr Thr Gly Ala Phe Arg Cys Leu Val Glu Lys Gly Asp Val Ala Phe
    1250                1255                1260
Cys Xaa Lys His Gln Thr Val Pro Thr Gly Thr Leu Gly Gly Glu Lys
1265                1270                1275                1280
Asn Pro Asp Pro Trp Ala Lys Asp Leu Asn Glu Lys Asp Tyr Glu Leu
                1285                1290                1295
Leu Cys Leu Gly Trp Val Pro Gly Lys Pro Val Glu Glu Tyr Ala Asn
            1300                1305                1310
Cys His Leu Ala Arg Ala Pro Asn His Arg Cys Gly Ser His Gly Lys
        1315                1320                1325
Asp Lys Glu Ala Cys Val His Lys Ile Leu Arg Ser Thr Ala Ser His
    1330                1335                1340
Leu Phe Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Trp Leu Val
1345                1350                1355                1360
Arg Ser Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys Leu
                1365                1370                1375
Trp Ala Lys Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu
            1380                1385                1390
Glu Tyr Val Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser
        1395                1400                1405
Leu Leu Glu Ala Cys Thr Phe Arg Arg Pro
    1410                1415

<210> 805
<211> 1410
<212> PRT
<213> Homo sapiens

<400> 805
Met Gly Pro Trp Ala Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Val Pro Asp Lys Thr
                725                 730                 735
Val Arg Trp Cys Ala Val Ser Glu His Glu Ala Thr Lys Cys Gln Ser
            740                 745                 750
Phe Arg Asp His Met Lys Ser Val Ile Pro Ser Asp Gly Pro Ser Val
        755                 760                 765
Ala Cys Val Lys Lys Ala Ser Tyr Leu Asp Cys Ile Arg Ala Ile Ala
    770                 775                 780
Ala Asn Glu Ala Asp Ala Val Thr Leu Asp Ala Gly Leu Val Tyr Asp
785                 790                 795                 800
Ala Tyr Leu Ala Pro Asn Asn Leu Lys Pro Val Val Ala Glu Phe Tyr
                805                 810                 815
Gly Ser Lys Glu Asp Pro Gln Thr Phe Tyr Tyr Ala Val Ala Val Val
            820                 825                 830
Lys Lys Asp Ser Gly Phe Gln Met Asn Gln Leu Arg Gly Lys Lys Ser
        835                 840                 845
Cys His Thr Gly Leu Gly Arg Ser Ala Gly Trp Asn Ile Pro Ile Gly
    850                 855                 860
Leu Leu Tyr Cys Asp Leu Pro Glu Pro Arg Lys Pro Leu Glu Lys Ala
865                 870                 875                 880
Val Ala Asn Phe Phe Ser Gly Ser Cys Ala Pro Cys Ala Asp Gly Thr
                885                 890                 895
Asp Phe Pro Gln Leu Cys Gln Leu Cys Pro Gly Cys Gly Cys Ser Thr
            900                 905                 910
Leu Asn Gln Tyr Phe Gly Tyr Ser Gly Ala Phe Lys Cys Leu Lys Asp
        915                 920                 925
Gly Ala Gly Asp Val Ala Phe Val Lys His Ser Thr Ile Phe Glu Asn
    930                 935                 940
Leu Ala Asn Lys Ala Asp Arg Asp Gln Tyr Glu Leu Leu Cys Leu Asp
945                 950                 955                 960
Asn Thr Arg Lys Pro Val Asp Glu Tyr Lys Asp Cys His Leu Ala Gln
                965                 970                 975
Val Pro Ser His Thr Val Val Ala Arg Ser Met Gly Gly Lys Glu Asp
            980                 985                 990
Leu Ile Trp Glu Leu Leu Asn Gln Ala Gln Glu His Phe Gly Lys Asp
        995                 1000                1005
Lys Ser Lys Glu Phe Gln Leu Phe Ser Ser Pro His Gly Lys Asp Leu
    1010                1015                1020
Leu Phe Lys Asp Ser Ala His Gly Phe Leu Lys Val Pro Gln Arg Met
1025                1030                1035                1040
Asp Ala Lys Met Tyr Leu Gly Tyr Glu Tyr Val Thr Ala Ile Arg Asn
                1045                1050                1055
Leu Arg Glu Gly Thr Cys Pro Glu Ala Pro Thr Asp Glu Cys Lys Pro
            1060                1065                1070
Val Lys Trp Cys Ala Leu Ser His His Glu Arg Leu Lys Cys Asp Glu
        1075                1080                1085
Trp Ser Val Asn Ser Val Gly Lys Ile Glu Cys Val Ser Ala Glu Thr
    1090                1095                1100
Thr Glu Asp Cys Ile Ala Lys Ile Met Asn Gly Glu Ala Asp Ala Met
1105                1110                1115                1120
Ser Leu Asp Gly Gly Phe Val Tyr Ile Ala Gly Lys Cys Gly Leu Val
                1125                1130                1135
Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser Asp Asn Cys Glu Asp Thr
            1140                1145                1150
Pro Glu Ala Gly Tyr Phe Ala Val Ala Val Val Lys Lys Ser Ala Ser
        1155                1160                1165
Asp Leu Thr Trp Asp Asn Leu Lys Gly Lys Lys Ser Cys His Thr Ala
    1170                1175                1180
Val Gly Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Tyr Asn
1185                1190                1195                1200
Lys Ile Asn His Cys Arg Phe Asp Glu Phe Phe Ser Glu Gly Cys Ala
                1205                1210                1215
Pro Gly Ser Lys Lys Asp Ser Ser Leu Cys Lys Leu Cys Met Gly Ser
            1220                1225                1230
Gly Leu Asn Leu Cys Gln Pro Asn Asn Lys Glu Gly Tyr Tyr Gly Tyr
        1235                1240                1245
Thr Gly Ala Phe Arg Cys Leu Val Glu Lys Gly Asp Val Ala Phe Val
    1250                1255                1260
Lys His Gln Thr Val Pro Gln Asn Thr Gly Gly Lys Asn Pro Asp Pro
1265                1270                1275                1280
Trp Ala Lys Asn Leu Asn Glu Lys Asp Tyr Glu Leu Leu Cys Leu Asp
                1285                1290                1295
Gly Thr Arg Lys Pro Val Glu Glu Tyr Ala Asn Cys His Leu Ala Arg
            1300                1305                1310
Ala Pro Asn His Ala Val Val Thr Arg Lys Asp Lys Glu Ala Cys Val
        1315                1320                1325
His Lys Ile Leu Arg Gln Gln Gln His Leu Phe Gly Ser Asn Val Thr
    1330                1335                1340
Asp Cys Ser Gly Asn Phe Cys Leu Phe Arg Ser Glu Thr Lys Asp Leu
1345                1350                1355                1360
Leu Phe Arg Asp Asp Thr Val Cys Leu Ala Lys Leu His Asp Arg Asn
                1365                1370                1375
Thr Tyr Glu Lys Tyr Leu Gly Glu Glu Tyr Val Lys Ala Val Gly Asn
            1380                1385                1390
Leu Arg Lys Cys Ser Thr Ser Ser Leu Leu Glu Ala Cys Thr Phe Arg
        1395                1400                1405
Arg Pro
    1410

<210> 806
<211> 872
<212> PRT
<213> Homo sapiens

<400> 806
Ser Gly Ser Gly His Cys Leu Ala Glu Ala Ala Ser Met Gly Pro Trp
 1               5                  10                  15
Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu Ala Ala Ala Gly
            20                  25                  30
Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe Gln Cys Gln Asp
        35                  40                  45
Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly Ser Ala Glu Cys
    50                  55                  60
Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu Ser Val Thr Cys
65                  70                  75                  80
Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn Arg Cys Ile Pro
                85                  90                  95
Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp Asn Gly Ser Asp
            100                 105                 110
Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp Glu Phe Arg Cys
        115                 120                 125
His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys Asp Ser Asp Arg
    130                 135                 140
Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys
145                 150                 155                 160
Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu
                165                 170                 175
Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp
            180                 185                 190
Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro
        195                 200                 205
Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu Cys Ile His Ser
    210                 215                 220
Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu
225                 230                 235                 240
Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser
                245                 250                 255
Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp
            260                 265                 270
Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys
        275                 280                 285
Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu
    290                 295                 300
Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu
305                 310                 315                 320
Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly
                325                 330                 335
Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys
            340                 345                 350
Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp
        355                 360                 365
Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu
    370                 375                 380
Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His
385                 390                 395                 400
Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr
                405                 410                 415
Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr
            420                 425                 430
Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val
        435                 440                 445
Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys
    450                 455                 460
Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val
465                 470                 475                 480
Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile
                485                 490                 495
His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val
            500                 505                 510
Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly
        515                 520                 525
Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr
    530                 535                 540
Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn
545                 550                 555                 560
Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn
                565                 570                 575
Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser
            580                 585                 590
Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys
        595                 600                 605
Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala
    610                 615                 620
Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile
625                 630                 635                 640
Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu
                645                 650                 655
Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln
            660                 665                 670
Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly
        675                 680                 685
Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro
    690                 695                 700
Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met
705                 710                 715                 720
Arg Ser Cys Leu Thr Glu Gly Glu Ala Ala Val Ala Thr Gln Glu Thr
                725                 730                 735
Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His
            740                 745                 750
Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr
        755                 760                 765
Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser His Gln Ala Leu
    770                 775                 780
Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg
785                 790                 795                 800
Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu
                805                 810                 815
Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser
            820                 825                 830
Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val
        835                 840                 845
His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met
    850                 855                 860
Val Ser Leu Glu Asp Asp Val Ala
865                 870

<210> 807
<211> 860
<212> PRT
<213> Homo sapiens

<400> 807
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860

<210> 808
<211> 860
<212> PRT
<213> Homo sapiens

<400> 808
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860

<210> 809
<211> 837
<212> PRT
<213> Homo sapiens

<400> 809
Gly Asp Arg Cys Glu Arg Asn Glu Phe Gln Cys Gln Asp Gly Lys Cys
 1               5                  10                  15
Ile Ser Tyr Lys Trp Val Cys Asp Gly Ser Ala Glu Cys Gln Asp Gly
            20                  25                  30
Ser Asp Glu Ser Gln Glu Thr Cys Leu Ser Val Thr Cys Lys Ser Gly
        35                  40                  45
Asp Phe Ser Cys Gly Gly Arg Val Asn Arg Cys Ile Pro Gln Phe Trp
    50                  55                  60
Arg Cys Asp Gly Gln Val Asp Cys Asp Asn Gly Ser Asp Glu Gln Gly
65                  70                  75                  80
Cys Pro Pro Lys Thr Cys Ser Gln Asp Glu Phe Arg Cys His Asp Gly
                85                  90                  95
Lys Cys Ile Ser Arg Gln Phe Val Cys Asp Ser Asp Arg Asp Cys Leu
            100                 105                 110
Asp Gly Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys Gly Pro Ala
        115                 120                 125
Ser Phe Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp Ala Cys
    130                 135                 140
Asp Asn Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro Gln Arg
145                 150                 155                 160
Cys Arg Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys Ser Ala
                165                 170                 175
Phe Glu Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser Trp Arg
            180                 185                 190
Cys Asp Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu Asn Cys
        195                 200                 205
Ala Val Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp Gly Asn
    210                 215                 220
Cys Ile His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp
225                 230                 235                 240
Met Ser Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro
                245                 250                 255
Asn Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val
            260                 265                 270
Cys Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys
        275                 280                 285
Glu Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His
    290                 295                 300
Val Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly
305                 310                 315                 320
Phe Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln
                325                 330                 335
Asp Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr
            340                 345                 350
Lys Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala
        355                 360                 365
Cys Lys Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His
    370                 375                 380
Glu Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile
385                 390                 395                 400
Pro Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn
                405                 410                 415
Arg Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln
            420                 425                 430
Leu Asp Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg
        435                 440                 445
Asp Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn
    450                 455                 460
Ile Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr
465                 470                 475                 480
Lys Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro
                485                 490                 495
Arg Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp
            500                 505                 510
Trp Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp
        515                 520                 525
Ile Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr
    530                 535                 540
Leu Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His
545                 550                 555                 560
Ser Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu
                565                 570                 575
Glu Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu
            580                 585                 590
Asp Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala
        595                 600                 605
Asn Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu
    610                 615                 620
Ser Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly
625                 630                 635                 640
Val Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr
                645                 650                 655
Leu Cys Leu Pro Ala Ser Gln Ile Asn Pro His Ser Pro Lys Phe Thr
            660                 665                 670
Cys Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys
        675                 680                 685
Leu Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val
    690                 695                 700
Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr
705                 710                 715                 720
Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu
                725                 730                 735
Thr Thr Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val
            740                 745                 750
Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser
        755                 760                 765
Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe
    770                 775                 780
Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe
785                 790                 795                 800
Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys
                805                 810                 815
His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu
            820                 825                 830
Glu Asp Asp Val Ala
        835

<210> 810
<211> 2214
<212> PRT
<213> Homo sapiens

<400> 810
Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe
 1               5                  10                  15
Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr
            20                  25                  30
Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe
        35                  40                  45
Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly
    50                  55                  60
Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys
65                  70                  75                  80
Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val
                85                  90                  95
Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu
            100                 105                 110
Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala
        115                 120                 125
Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser
    130                 135                 140
Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser
145                 150                 155                 160
Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg
                165                 170                 175
Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp
            180                 185                 190
Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp
        195                 200                 205
Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg
    210                 215                 220
Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr
225                 230                 235                 240
Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp
                245                 250                 255
Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser
            260                 265                 270
Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu
        275                 280                 285
Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp
    290                 295                 300
Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln
305                 310                 315                 320
Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg
                325                 330                 335
Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala
            340                 345                 350
Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn
        355                 360                 365
Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu
    370                 375                 380
Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp
385                 390                 395                 400
Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg
                405                 410                 415
Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser
            420                 425                 430
Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly
        435                 440                 445
Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys
    450                 455                 460
Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg
465                 470                 475                 480
Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser
                485                 490                 495
Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys
            500                 505                 510
Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala
        515                 520                 525
Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp
    530                 535                 540
His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu
545                 550                 555                 560
Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe
                565                 570                 575
Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu
            580                 585                 590
Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His
        595                 600                 605
Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro
    610                 615                 620
Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly
625                 630                 635                 640
Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro
                645                 650                 655
His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val
            660                 665                 670
Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe
        675                 680                 685
Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu
    690                 695                 700
Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser
705                 710                 715                 720
Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys
                725                 730                 735
Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys
            740                 745                 750
Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser
        755                 760                 765
Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu
    770                 775                 780
Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn
785                 790                 795                 800
Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys
                805                 810                 815
Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu
            820                 825                 830
Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp
        835                 840                 845
Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp
    850                 855                 860
Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala
865                 870                 875                 880
Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly
                885                 890                 895
Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala
            900                 905                 910
Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val
        915                 920                 925
Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu
    930                 935                 940
Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu
945                 950                 955                 960
Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp
                965                 970                 975
Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser
            980                 985                 990
Gln Met Glu Ile Leu Ala Asn Gln Leu Thr Gly Leu Met Asp Met Lys
        995                 1000                1005
Ile Phe Tyr Lys Gly Lys Asn Thr Gly Ser Asn Ala Cys Val Pro Arg
    1010                1015                1020
Pro Cys Ser Leu Leu Cys Leu Pro Lys Ala Asn Asn Ser Arg Ser Cys
1025                1030                1035                1040
Arg Cys Pro Glu Asp Val Ser Ser Ser Val Leu Pro Ser Gly Asp Leu
                1045                1050                1055
Met Cys Asp Cys Pro Gln Gly Tyr Gln Leu Lys Asn Asn Thr Cys Val
            1060                1065                1070
Lys Glu Glu Asn Thr Cys Leu Arg Asn Gln Tyr Arg Cys Ser Asn Gly
        1075                1080                1085
Asn Cys Ile Asn Ser Ile Trp Trp Cys Asp Phe Asp Asn Asp Cys Gly
    1090                1095                1100
Asp Met Ser Asp Glu Arg Asn Cys Pro Thr Thr Ile Cys Asp Leu Asp
1105                1110                1115                1120
Thr Gln Phe Arg Cys Gln Glu Ser Gly Thr Cys Ile Pro Leu Ser Tyr
                1125                1130                1135
Lys Cys Asp Leu Glu Asp Asp Cys Gly Asp Asn Ser Asp Glu Ser His
            1140                1145                1150
Cys Glu Met His Gln Cys Arg Ser Asp Glu Tyr Asn Cys Ser Ser Gly
        1155                1160                1165
Met Cys Ile Arg Ser Ser Trp Val Cys Asp Gly Asp Asn Asp Cys Arg
    1170                1175                1180
Asp Trp Ser Asp Glu Ala Asn Cys Thr Ala Ile Tyr His Thr Cys Glu
1185                1190                1195                1200
Ala Ser Asn Phe Gln Cys Arg Asn Gly His Cys Ile Pro Gln Arg Trp
                1205                1210                1215
Ala Cys Asp Gly Asp Thr Asp Cys Gln Asp Gly Ser Asp Glu Asp Pro
            1220                1225                1230
Val Asn Cys Glu Lys Lys Cys Asn Gly Phe Arg Cys Pro Asn Gly Thr
        1235                1240                1245
Cys Ile Pro Ser Ser Lys His Cys Asp Gly Leu Arg Asp Cys Ser Asp
    1250                1255                1260
Gly Ser Asp Glu Gln His Cys Glu Pro Leu Cys Thr His Phe Met Asp
1265                1270                1275                1280
Phe Val Cys Lys Asn Arg Gln Gln Cys Leu Phe His Ser Met Val Cys
                1285                1290                1295
Asp Gly Ile Ile Gln Cys Arg Asp Gly Ser Asp Glu Asp Ala Ala Phe
            1300                1305                1310
Ala Gly Cys Ser Gln Asp Pro Glu Phe His Lys Val Cys Asp Glu Phe
        1315                1320                1325
Gly Phe Gln Cys Gln Asn Gly Val Cys Ile Ser Leu Ile Trp Lys Cys
    1330                1335                1340
Asp Gly Met Asp Asp Cys Gly Asp Tyr Ser Asp Glu Ala Asn Cys Glu
1345                1350                1355                1360
Asn Pro Thr Glu Ala Pro Asn Cys Ser Arg Tyr Phe Gln Phe Arg Cys
                1365                1370                1375
Glu Asn Gly His Cys Ile Pro Asn Arg Trp Lys Cys Asp Arg Glu Asn
            1380                1385                1390
Asp Cys Gly Asp Trp Ser Asp Glu Lys Asp Cys Gly Asp Ser His Ile
        1395                1400                1405
Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Cys Leu Pro Asn Tyr Tyr
    1410                1415                1420
Arg Cys Ser Ser Gly Thr Cys Val Met Asp Thr Trp Val Cys Asp Gly
1425                1430                1435                1440
Tyr Arg Asp Cys Ala Asp Gly Ser Asp Glu Glu Ala Cys Pro Leu Leu
                1445                1450                1455
Ala Asn Val Thr Ala Ala Ser Thr Pro Thr Gln Leu Gly Arg Cys Asp
            1460                1465                1470
Arg Phe Glu Phe Glu Cys His Gln Pro Lys Thr Cys Ile Pro Asn Trp
        1475                1480                1485
Lys Arg Cys Asp Gly His Gln Asp Cys Gln Asp Gly Arg Asp Glu Ala
    1490                1495                1500
Asn Cys Pro Thr His Ser Thr Leu Thr Cys Met Ser Arg Glu Phe Gln
1505                1510                1515                1520
Cys Glu Asp Gly Glu Ala Cys Ile Val Leu Ser Glu Arg Cys Asp Gly
                1525                1530                1535
Phe Leu Asp Cys Ser Asp Glu Ser Asp Glu Lys Ala Cys Ser Asp Glu
            1540                1545                1550
Leu Thr Val Tyr Lys Val Gln Asn Leu Gln Trp Thr Ala Asp Phe Ser
        1555                1560                1565
Gly Asp Val Thr Leu Thr Trp Met Arg Pro Lys Lys Met Pro Ser Ala
    1570                1575                1580
Ser Cys Val Tyr Asn Val Tyr Tyr Arg Val Val Gly Glu Ser Ile Trp
1585                1590                1595                1600
Lys Thr Leu Glu Thr His Ser Asn Lys Thr Asn Thr Val Leu Lys Val
                1605                1610                1615
Leu Lys Pro Asp Thr Thr Tyr Gln Val Lys Val Gln Val Gln Cys Leu
            1620                1625                1630
Ser Lys Ala His Asn Thr Asn Asp Phe Val Thr Leu Arg Thr Pro Glu
        1635                1640                1645
Gly Leu Pro Asp Ala Pro Arg Asn Leu Gln Leu Ser Leu Pro Arg Glu
    1650                1655                1660
Ala Glu Gly Val Ile Val Gly His Trp Ala Pro Pro Ile His Thr His
1665                1670                1675                1680
Gly Leu Ile Arg Glu Tyr Ile Val Glu Tyr Ser Arg Ser Gly Ser Lys
                1685                1690                1695
Met Trp Ala Ser Gln Arg Ala Ala Ser Asn Phe Thr Glu Ile Lys Asn
            1700                1705                1710
Leu Leu Val Asn Thr Leu Tyr Thr Val Arg Val Ala Ala Val Thr Ser
        1715                1720                1725
Arg Gly Ile Gly Asn Trp Ser Asp Ser Lys Ser Ile Thr Thr Ile Lys
    1730                1735                1740
Gly Lys Val Ile Pro Pro Pro Asp Ile His Ile Asp Ser Tyr Gly Glu
1745                1750                1755                1760
Asn Tyr Leu Ser Phe Thr Leu Thr Met Glu Ser Asp Ile Lys Val Asn
                1765                1770                1775
Gly Tyr Val Val Asn Leu Phe Trp Ala Phe Asp Thr His Lys Gln Glu
            1780                1785                1790
Arg Arg Thr Leu Asn Phe Arg Gly Ser Ile Leu Ser His Lys Val Gly
        1795                1800                1805
Asn Leu Thr Ala His Thr Ser Tyr Glu Ile Ser Ala Trp Ala Lys Thr
    1810                1815                1820
Asp Leu Gly Asp Ser Pro Leu Ala Phe Glu His Val Met Thr Arg Gly
1825                1830                1835                1840
Val Arg Pro Pro Ala Pro Ser Leu Lys Ala Lys Ala Ile Asn Gln Thr
                1845                1850                1855
Ala Val Glu Cys Thr Trp Thr Gly Pro Arg Asn Val Val Tyr Gly Ile
            1860                1865                1870
Phe Tyr Ala Thr Ser Phe Leu Asp Leu Tyr Arg Asn Pro Lys Ser Leu
        1875                1880                1885
Thr Thr Ser Leu His Asn Lys Thr Val Ile Val Ser Lys Asp Glu Gln
    1890                1895                1900
Tyr Leu Phe Leu Val Arg Val Val Val Pro Tyr Gln Gly Pro Ser Ser
1905                1910                1915                1920
Asp Tyr Val Val Val Lys Met Ile Pro Asp Ser Arg Leu Pro Pro Arg
                1925                1930                1935
His Leu His Val Val His Thr Gly Lys Thr Ser Val Val Ile Lys Trp
            1940                1945                1950
Glu Ser Pro Tyr Asp Ser Pro Asp Gln Asp Leu Leu Tyr Ala Ile Ala
        1955                1960                1965
Val Lys Asp Leu Ile Arg Lys Thr Asp Arg Ser Tyr Lys Val Lys Ser
    1970                1975                1980
Arg Asn Ser Thr Val Glu Tyr Thr Leu Asn Lys Leu Glu Pro Gly Gly
1985                1990                1995                2000
Lys Tyr His Ile Ile Val Gln Leu Gly Asn Met Ser Lys Asp Ser Ser
                2005                2010                2015
Ile Lys Ile Thr Thr Val Ser Leu Ser Ala Pro Asp Ala Leu Lys Ile
            2020                2025                2030
Ile Thr Glu Asn Asp His Val Leu Leu Phe Trp Lys Ser Leu Ala Leu
        2035                2040                2045
Lys Glu Lys His Phe Asn Glu Ser Arg Gly Tyr Glu Ile His Met Phe
    2050                2055                2060
Asp Ser Ala Met Asn Ile Thr Ala Tyr Leu Gly Asn Thr Thr Asp Asn
2065                2070                2075                2080
Phe Phe Lys Ile Ser Asn Leu Lys Met Gly His Asn Tyr Thr Phe Thr
                2085                2090                2095
Val Gln Ala Arg Cys Leu Phe Gly Asn Gln Ile Cys Gly Glu Pro Ala
            2100                2105                2110
Ile Leu Leu Tyr Asp Glu Leu Gly Ser Gly Ala Asp Ala Ser Ala Thr
        2115                2120                2125
Gln Ala Ala Arg Ser Thr Asp Val Ala Ala Val Val Val Pro Ile Leu
    2130                2135                2140
Phe Leu Ile Leu Leu Ser Leu Gly Val Gly Phe Ala Ile Leu Tyr Thr
2145                2150                2155                2160
Lys His Arg Arg Leu Gln Ser Ser Phe Thr Ala Phe Ala Asn Ser His
                2165                2170                2175
Tyr Ser Ser Arg Leu Gly Ser Ala Ile Phe Ser Ser Gly Asp Asp Leu
            2180                2185                2190
Gly Glu Asp Asp Glu Asp Ala Pro Met Ile Thr Gly Phe Ser Asp Asp
        2195                2200                2205
Val Pro Met Val Ile Ala
    2210

<210> 811
<211> 2214
<212> PRT
<213> Homo sapiens

<400> 811
Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe
 1               5                  10                  15
Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr
            20                  25                  30
Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe
        35                  40                  45
Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly
    50                  55                  60
Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys
65                  70                  75                  80
Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val
                85                  90                  95
Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu
            100                 105                 110
Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala
        115                 120                 125
Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser
    130                 135                 140
Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser
145                 150                 155                 160
Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg
                165                 170                 175
Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp
            180                 185                 190
Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp
        195                 200                 205
Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg
    210                 215                 220
Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr
225                 230                 235                 240
Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp
                245                 250                 255
Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser
            260                 265                 270
Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu
        275                 280                 285
Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp
    290                 295                 300
Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln
305                 310                 315                 320
Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg
                325                 330                 335
Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala
            340                 345                 350
Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn
        355                 360                 365
Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu
    370                 375                 380
Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp
385                 390                 395                 400
Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg
                405                 410                 415
Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser
            420                 425                 430
Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly
        435                 440                 445
Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys
    450                 455                 460
Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg
465                 470                 475                 480
Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser
                485                 490                 495
Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys
            500                 505                 510
Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala
        515                 520                 525
Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp
    530                 535                 540
His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu
545                 550                 555                 560
Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe
                565                 570                 575
Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu
            580                 585                 590
Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His
        595                 600                 605
Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro
    610                 615                 620
Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly
625                 630                 635                 640
Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro
                645                 650                 655
His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val
            660                 665                 670
Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe
        675                 680                 685
Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu
    690                 695                 700
Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser
705                 710                 715                 720
Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys
                725                 730                 735
Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys
            740                 745                 750
Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser
        755                 760                 765
Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu
    770                 775                 780
Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn
785                 790                 795                 800
Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys
                805                 810                 815
Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu
            820                 825                 830
Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp
        835                 840                 845
Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp
    850                 855                 860
Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala
865                 870                 875                 880
Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly
                885                 890                 895
Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala
            900                 905                 910
Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val
        915                 920                 925
Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu
    930                 935                 940
Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu
945                 950                 955                 960
Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp
                965                 970                 975
Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser
            980                 985                 990
Gln Met Glu Ile Leu Ala Asn Gln Leu Thr Gly Leu Met Asp Met Lys
        995                 1000                1005
Ile Phe Tyr Lys Gly Lys Asn Thr Gly Ser Asn Ala Cys Val Pro Arg
    1010                1015                1020
Pro Cys Ser Leu Leu Cys Leu Pro Lys Ala Asn Asn Ser Arg Ser Cys
1025                1030                1035                1040
Arg Cys Pro Glu Asp Val Ser Ser Ser Val Leu Pro Ser Gly Asp Leu
                1045                1050                1055
Met Cys Asp Cys Pro Gln Gly Tyr Gln Leu Lys Asn Asn Thr Cys Val
            1060                1065                1070
Lys Glu Glu Asn Thr Cys Leu Arg Asn Gln Tyr Arg Cys Ser Asn Gly
        1075                1080                1085
Asn Cys Ile Asn Ser Ile Trp Trp Cys Asp Phe Asp Asn Asp Cys Gly
    1090                1095                1100
Asp Met Ser Asp Glu Arg Asn Cys Pro Thr Thr Ile Cys Asp Leu Asp
1105                1110                1115                1120
Thr Gln Phe Arg Cys Gln Glu Ser Gly Thr Cys Ile Pro Leu Ser Tyr
                1125                1130                1135
Lys Cys Asp Leu Glu Asp Asp Cys Gly Asp Asn Ser Asp Glu Ser His
            1140                1145                1150
Cys Glu Met His Gln Cys Arg Ser Asp Glu Tyr Asn Cys Ser Ser Gly
        1155                1160                1165
Met Cys Ile Arg Ser Ser Trp Val Cys Asp Gly Asp Asn Asp Cys Arg
    1170                1175                1180
Asp Trp Ser Asp Glu Ala Asn Cys Thr Ala Ile Tyr His Thr Cys Glu
1185                1190                1195                1200
Ala Ser Asn Phe Gln Cys Arg Asn Gly His Cys Ile Pro Gln Arg Trp
                1205                1210                1215
Ala Cys Asp Gly Asp Thr Asp Cys Gln Asp Gly Ser Asp Glu Asp Pro
            1220                1225                1230
Val Asn Cys Glu Lys Lys Cys Asn Gly Phe Arg Cys Pro Asn Gly Thr
        1235                1240                1245
Cys Ile Pro Ser Ser Lys His Cys Asp Gly Leu Arg Asp Cys Ser Asp
    1250                1255                1260
Gly Ser Asp Glu Gln His Cys Glu Pro Leu Cys Thr His Phe Met Asp
1265                1270                1275                1280
Phe Val Cys Lys Asn Arg Gln Gln Cys Leu Phe His Ser Met Val Cys
                1285                1290                1295
Asp Gly Ile Ile Gln Cys Arg Asp Gly Ser Asp Glu Asp Ala Ala Phe
            1300                1305                1310
Ala Gly Cys Ser Gln Asp Pro Glu Phe His Lys Val Cys Asp Glu Phe
        1315                1320                1325
Gly Phe Gln Cys Gln Asn Gly Val Cys Ile Ser Leu Ile Trp Lys Cys
    1330                1335                1340
Asp Gly Met Asp Asp Cys Gly Asp Tyr Ser Asp Glu Ala Asn Cys Glu
1345                1350                1355                1360
Asn Pro Thr Glu Ala Pro Asn Cys Ser Arg Tyr Phe Gln Phe Arg Cys
                1365                1370                1375
Glu Asn Gly His Cys Ile Pro Asn Arg Trp Lys Cys Asp Arg Glu Asn
            1380                1385                1390
Asp Cys Gly Asp Trp Ser Asp Glu Lys Asp Cys Gly Asp Ser His Ile
        1395                1400                1405
Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Cys Leu Pro Asn Tyr Tyr
    1410                1415                1420
Arg Cys Ser Ser Gly Thr Cys Val Met Asp Thr Trp Val Cys Asp Gly
1425                1430                1435                1440
Tyr Arg Asp Cys Ala Asp Gly Ser Asp Glu Glu Ala Cys Pro Leu Leu
                1445                1450                1455
Ala Asn Val Thr Ala Ala Ser Thr Pro Thr Gln Leu Gly Arg Cys Asp
            1460                1465                1470
Arg Phe Glu Phe Glu Cys His Gln Pro Lys Thr Cys Ile Pro Asn Trp
        1475                1480                1485
Lys Arg Cys Asp Gly His Gln Asp Cys Gln Asp Gly Arg Asp Glu Ala
    1490                1495                1500
Asn Cys Pro Thr His Ser Thr Leu Thr Cys Met Ser Arg Glu Phe Gln
1505                1510                1515                1520
Cys Glu Asp Gly Glu Ala Cys Ile Val Leu Ser Glu Arg Cys Asp Gly
                1525                1530                1535
Phe Leu Asp Cys Ser Asp Glu Ser Asp Glu Lys Ala Cys Ser Asp Glu
            1540                1545                1550
Leu Thr Val Tyr Lys Val Gln Asn Leu Gln Trp Thr Ala Asp Phe Ser
        1555                1560                1565
Gly Asp Val Thr Leu Thr Trp Met Arg Pro Lys Lys Met Pro Ser Ala
    1570                1575                1580
Ser Cys Val Tyr Asn Val Tyr Tyr Arg Val Val Gly Glu Ser Ile Trp
1585                1590                1595                1600
Lys Thr Leu Glu Thr His Ser Asn Lys Thr Asn Thr Val Leu Lys Val
                1605                1610                1615
Leu Lys Pro Asp Thr Thr Tyr Gln Val Lys Val Gln Val Gln Cys Leu
            1620                1625                1630
Ser Lys Ala His Asn Thr Asn Asp Phe Val Thr Leu Arg Thr Pro Glu
        1635                1640                1645
Gly Leu Pro Asp Ala Pro Arg Asn Leu Gln Leu Ser Leu Pro Arg Glu
    1650                1655                1660
Ala Glu Gly Val Ile Val Gly His Trp Ala Pro Pro Ile His Thr His
1665                1670                1675                1680
Gly Leu Ile Arg Glu Tyr Ile Val Glu Tyr Ser Arg Ser Gly Ser Lys
                1685                1690                1695
Met Trp Ala Ser Gln Arg Ala Ala Ser Asn Phe Thr Glu Ile Lys Asn
            1700                1705                1710
Leu Leu Val Asn Thr Leu Tyr Thr Val Arg Val Ala Ala Val Thr Ser
        1715                1720                1725
Arg Gly Ile Gly Asn Trp Ser Asp Ser Lys Ser Ile Thr Thr Ile Lys
    1730                1735                1740
Gly Lys Val Ile Pro Pro Pro Asp Ile His Ile Asp Ser Tyr Gly Glu
1745                1750                1755                1760
Asn Tyr Leu Ser Phe Thr Leu Thr Met Glu Ser Asp Ile Lys Val Asn
                1765                1770                1775
Gly Tyr Val Val Asn Leu Phe Trp Ala Phe Asp Thr His Lys Gln Glu
            1780                1785                1790
Arg Arg Thr Leu Asn Phe Arg Gly Ser Ile Leu Ser His Lys Val Gly
        1795                1800                1805
Asn Leu Thr Ala His Thr Ser Tyr Glu Ile Ser Ala Trp Ala Lys Thr
    1810                1815                1820
Asp Leu Gly Asp Ser Pro Leu Ala Phe Glu His Val Met Thr Arg Gly
1825                1830                1835                1840
Val Arg Pro Pro Ala Pro Ser Leu Lys Ala Lys Ala Ile Asn Gln Thr
                1845                1850                1855
Ala Val Glu Cys Thr Trp Thr Gly Pro Arg Asn Val Val Tyr Gly Ile
            1860                1865                1870
Phe Tyr Ala Thr Ser Phe Leu Asp Leu Tyr Arg Asn Pro Lys Ser Leu
        1875                1880                1885
Thr Thr Ser Leu His Asn Lys Thr Val Ile Val Ser Lys Asp Glu Gln
    1890                1895                1900
Tyr Leu Phe Leu Val Arg Val Val Val Pro Tyr Gln Gly Pro Ser Ser
1905                1910                1915                1920
Asp Tyr Val Val Val Lys Met Ile Pro Asp Ser Arg Leu Pro Pro Arg
                1925                1930                1935
His Leu His Val Val His Thr Gly Lys Thr Ser Val Val Ile Lys Trp
            1940                1945                1950
Glu Ser Pro Tyr Asp Ser Pro Asp Gln Asp Leu Leu Tyr Ala Ile Ala
        1955                1960                1965
Val Lys Asp Leu Ile Arg Lys Thr Asp Arg Ser Tyr Lys Val Lys Ser
    1970                1975                1980
Arg Asn Ser Thr Val Glu Tyr Thr Leu Asn Lys Leu Glu Pro Gly Gly
1985                1990                1995                2000
Lys Tyr His Ile Ile Val Gln Leu Gly Asn Met Ser Lys Asp Ser Ser
                2005                2010                2015
Ile Lys Ile Thr Thr Val Ser Leu Ser Ala Pro Asp Ala Leu Lys Ile
            2020                2025                2030
Ile Thr Glu Asn Asp His Val Leu Leu Phe Trp Lys Ser Leu Ala Leu
        2035                2040                2045
Lys Glu Lys His Phe Asn Glu Ser Arg Gly Tyr Glu Ile His Met Phe
    2050                2055                2060
Asp Ser Ala Met Asn Ile Thr Ala Tyr Leu Gly Asn Thr Thr Asp Asn
2065                2070                2075                2080
Phe Phe Lys Ile Ser Asn Leu Lys Met Gly His Asn Tyr Thr Phe Thr
                2085                2090                2095
Val Gln Ala Arg Cys Leu Phe Gly Asn Gln Ile Cys Gly Glu Pro Ala
            2100                2105                2110
Ile Leu Leu Tyr Asp Glu Leu Gly Ser Gly Ala Asp Ala Ser Ala Thr
        2115                2120                2125
Gln Ala Ala Arg Ser Thr Asp Val Ala Ala Val Val Val Pro Ile Leu
    2130                2135                2140
Phe Leu Ile Leu Leu Ser Leu Gly Val Gly Phe Ala Ile Leu Tyr Thr
2145                2150                2155                2160
Lys His Arg Arg Leu Gln Ser Ser Phe Thr Ala Phe Ala Asn Ser His
                2165                2170                2175
Tyr Ser Ser Arg Leu Gly Ser Ala Ile Phe Ser Ser Gly Asp Asp Leu
            2180                2185                2190
Gly Glu Asp Asp Glu Asp Ala Pro Met Ile Thr Gly Phe Ser Asp Asp
        2195                2200                2205
Val Pro Met Val Ile Ala
    2210

<210> 812
<211> 2214
<212> PRT
<213> Homo sapiens

<400> 812
Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe
 1               5                  10                  15
Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr
            20                  25                  30
Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe
        35                  40                  45
Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly
    50                  55                  60
Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys
65                  70                  75                  80
Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val
                85                  90                  95
Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu
            100                 105                 110
Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala
        115                 120                 125
Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser
    130                 135                 140
Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser
145                 150                 155                 160
Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg
                165                 170                 175
Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp
            180                 185                 190
Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp
        195                 200                 205
Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg
    210                 215                 220
Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr
225                 230                 235                 240
Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp
                245                 250                 255
Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser
            260                 265                 270
Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu
        275                 280                 285
Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp
    290                 295                 300
Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln
305                 310                 315                 320
Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg
                325                 330                 335
Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala
            340                 345                 350
Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn
        355                 360                 365
Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu
    370                 375                 380
Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp
385                 390                 395                 400
Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg
                405                 410                 415
Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser
            420                 425                 430
Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly
        435                 440                 445
Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys
    450                 455                 460
Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg
465                 470                 475                 480
Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser
                485                 490                 495
Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys
            500                 505                 510
Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala
        515                 520                 525
Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp
    530                 535                 540
His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu
545                 550                 555                 560
Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe
                565                 570                 575
Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu
            580                 585                 590
Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His
        595                 600                 605
Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro
    610                 615                 620
Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly
625                 630                 635                 640
Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro
                645                 650                 655
His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val
            660                 665                 670
Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe
        675                 680                 685
Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu
    690                 695                 700
Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser
705                 710                 715                 720
Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys
                725                 730                 735
Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys
            740                 745                 750
Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser
        755                 760                 765
Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu
    770                 775                 780
Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn
785                 790                 795                 800
Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys
                805                 810                 815
Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu
            820                 825                 830
Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp
        835                 840                 845
Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp
    850                 855                 860
Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala
865                 870                 875                 880
Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly
                885                 890                 895
Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala
            900                 905                 910
Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val
        915                 920                 925
Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu
    930                 935                 940
Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu
945                 950                 955                 960
Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp
                965                 970                 975
Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser
            980                 985                 990
Gln Met Glu Ile Leu Ala Asn Gln Leu Thr Gly Leu Met Asp Met Lys
        995                 1000                1005
Ile Phe Tyr Lys Gly Lys Asn Thr Gly Ser Asn Ala Cys Val Pro Arg
    1010                1015                1020
Pro Cys Ser Leu Leu Cys Leu Pro Lys Ala Asn Asn Ser Arg Ser Cys
1025                1030                1035                1040
Arg Cys Pro Glu Asp Val Ser Ser Ser Val Leu Pro Ser Gly Asp Leu
                1045                1050                1055
Met Cys Asp Cys Pro Gln Gly Tyr Gln Leu Lys Asn Asn Thr Cys Val
            1060                1065                1070
Lys Glu Glu Asn Thr Cys Leu Arg Asn Gln Tyr Arg Cys Ser Asn Gly
        1075                1080                1085
Asn Cys Ile Asn Ser Ile Trp Trp Cys Asp Phe Asp Asn Asp Cys Gly
    1090                1095                1100
Asp Met Ser Asp Glu Arg Asn Cys Pro Thr Thr Ile Cys Asp Leu Asp
1105                1110                1115                1120
Thr Gln Phe Arg Cys Gln Glu Ser Gly Thr Cys Ile Pro Leu Ser Tyr
                1125                1130                1135
Lys Cys Asp Leu Glu Asp Asp Cys Gly Asp Asn Ser Asp Glu Ser His
            1140                1145                1150
Cys Glu Met His Gln Cys Arg Ser Asp Glu Tyr Asn Cys Ser Ser Gly
        1155                1160                1165
Met Cys Ile Arg Ser Ser Trp Val Cys Asp Gly Asp Asn Asp Cys Arg
    1170                1175                1180
Asp Trp Ser Asp Glu Ala Asn Cys Thr Ala Ile Tyr His Thr Cys Glu
1185                1190                1195                1200
Ala Ser Asn Phe Gln Cys Arg Asn Gly His Cys Ile Pro Gln Arg Trp
                1205                1210                1215
Ala Cys Asp Gly Asp Thr Asp Cys Gln Asp Gly Ser Asp Glu Asp Pro
            1220                1225                1230
Val Asn Cys Glu Lys Lys Cys Asn Gly Phe Arg Cys Pro Asn Gly Thr
        1235                1240                1245
Cys Ile Pro Ser Ser Lys His Cys Asp Gly Leu Arg Asp Cys Ser Asp
    1250                1255                1260
Gly Ser Asp Glu Gln His Cys Glu Pro Leu Cys Thr His Phe Met Asp
1265                1270                1275                1280
Phe Val Cys Lys Asn Arg Gln Gln Cys Leu Phe His Ser Met Val Cys
                1285                1290                1295
Asp Gly Ile Ile Gln Cys Arg Asp Gly Ser Asp Glu Asp Ala Ala Phe
            1300                1305                1310
Ala Gly Cys Ser Gln Asp Pro Glu Phe His Lys Val Cys Asp Glu Phe
        1315                1320                1325
Gly Phe Gln Cys Gln Asn Gly Val Cys Ile Ser Leu Ile Trp Lys Cys
    1330                1335                1340
Asp Gly Met Asp Asp Cys Gly Asp Tyr Ser Asp Glu Ala Asn Cys Glu
1345                1350                1355                1360
Asn Pro Thr Glu Ala Pro Asn Cys Ser Arg Tyr Phe Gln Phe Arg Cys
                1365                1370                1375
Glu Asn Gly His Cys Ile Pro Asn Arg Trp Lys Cys Asp Arg Glu Asn
            1380                1385                1390
Asp Cys Gly Asp Trp Ser Asp Glu Lys Asp Cys Gly Asp Ser His Ile
        1395                1400                1405
Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Cys Leu Pro Asn Tyr Tyr
    1410                1415                1420
Arg Cys Ser Ser Gly Thr Cys Val Met Asp Thr Trp Val Cys Asp Gly
1425                1430                1435                1440
Tyr Arg Asp Cys Ala Asp Gly Ser Asp Glu Glu Ala Cys Pro Leu Leu
                1445                1450                1455
Ala Asn Val Thr Ala Ala Ser Thr Pro Thr Gln Leu Gly Arg Cys Asp
            1460                1465                1470
Arg Phe Glu Phe Glu Cys His Gln Pro Lys Thr Cys Ile Pro Asn Trp
        1475                1480                1485
Lys Arg Cys Asp Gly His Gln Asp Cys Gln Asp Gly Arg Asp Glu Ala
    1490                1495                1500
Asn Cys Pro Thr His Ser Thr Leu Thr Cys Met Ser Arg Glu Phe Gln
1505                1510                1515                1520
Cys Glu Asp Gly Glu Ala Cys Ile Val Leu Ser Glu Arg Cys Asp Gly
                1525                1530                1535
Phe Leu Asp Cys Ser Asp Glu Ser Asp Glu Lys Ala Cys Ser Asp Glu
            1540                1545                1550
Leu Thr Val Tyr Lys Val Gln Asn Leu Gln Trp Thr Ala Asp Phe Ser
        1555                1560                1565
Gly Asp Val Thr Leu Thr Trp Met Arg Pro Lys Lys Met Pro Ser Ala
    1570                1575                1580
Ser Cys Val Tyr Asn Val Tyr Tyr Arg Val Val Gly Glu Ser Ile Trp
1585                1590                1595                1600
Lys Thr Leu Glu Thr His Ser Asn Lys Thr Asn Thr Val Leu Lys Val
                1605                1610                1615
Leu Lys Pro Asp Thr Thr Tyr Gln Val Lys Val Gln Val Gln Cys Leu
            1620                1625                1630
Ser Lys Ala His Asn Thr Asn Asp Phe Val Thr Leu Arg Thr Pro Glu
        1635                1640                1645
Gly Leu Pro Asp Ala Pro Arg Asn Leu Gln Leu Ser Leu Pro Arg Glu
    1650                1655                1660
Ala Glu Gly Val Ile Val Gly His Trp Ala Pro Pro Ile His Thr His
1665                1670                1675                1680
Gly Leu Ile Arg Glu Tyr Ile Val Glu Tyr Ser Arg Ser Gly Ser Lys
                1685                1690                1695
Met Trp Ala Ser Gln Arg Ala Ala Ser Asn Phe Thr Glu Ile Lys Asn
            1700                1705                1710
Leu Leu Val Asn Thr Leu Tyr Thr Val Arg Val Ala Ala Val Thr Ser
        1715                1720                1725
Arg Gly Ile Gly Asn Trp Ser Asp Ser Lys Ser Ile Thr Thr Ile Lys
    1730                1735                1740
Gly Lys Val Ile Pro Pro Pro Asp Ile His Ile Asp Ser Tyr Gly Glu
1745                1750                1755                1760
Asn Tyr Leu Ser Phe Thr Leu Thr Met Glu Ser Asp Ile Lys Val Asn
                1765                1770                1775
Gly Tyr Val Val Asn Leu Phe Trp Ala Phe Asp Thr His Lys Gln Glu
            1780                1785                1790
Arg Arg Thr Leu Asn Phe Arg Gly Ser Ile Leu Ser His Lys Val Gly
        1795                1800                1805
Asn Leu Thr Ala His Thr Ser Tyr Glu Ile Ser Ala Trp Ala Lys Thr
    1810                1815                1820
Asp Leu Gly Asp Ser Pro Leu Ala Phe Glu His Val Met Thr Arg Gly
1825                1830                1835                1840
Val Arg Pro Pro Ala Pro Ser Leu Lys Ala Lys Ala Ile Asn Gln Thr
                1845                1850                1855
Ala Val Glu Cys Thr Trp Thr Gly Pro Arg Asn Val Val Tyr Gly Ile
            1860                1865                1870
Phe Tyr Ala Thr Ser Phe Leu Asp Leu Tyr Arg Asn Pro Lys Ser Leu
        1875                1880                1885
Thr Thr Ser Leu His Asn Lys Thr Val Ile Val Ser Lys Asp Glu Gln
    1890                1895                1900
Tyr Leu Phe Leu Val Arg Val Val Val Pro Tyr Gln Gly Pro Ser Ser
1905                1910                1915                1920
Asp Tyr Val Val Val Lys Met Ile Pro Asp Ser Arg Leu Pro Pro Arg
                1925                1930                1935
His Leu His Val Val His Thr Gly Lys Thr Ser Val Val Ile Lys Trp
            1940                1945                1950
Glu Ser Pro Tyr Asp Ser Pro Asp Gln Asp Leu Leu Tyr Ala Ile Ala
        1955                1960                1965
Val Lys Asp Leu Ile Arg Lys Thr Asp Arg Ser Tyr Lys Val Lys Ser
    1970                1975                1980
Arg Asn Ser Thr Val Glu Tyr Thr Leu Asn Lys Leu Glu Pro Gly Gly
1985                1990                1995                2000
Lys Tyr His Ile Ile Val Gln Leu Gly Asn Met Ser Lys Asp Ser Ser
                2005                2010                2015
Ile Lys Ile Thr Thr Val Ser Leu Ser Ala Pro Asp Ala Leu Lys Ile
            2020                2025                2030
Ile Thr Glu Asn Asp His Val Leu Leu Phe Trp Lys Ser Leu Ala Leu
        2035                2040                2045
Lys Glu Lys His Phe Asn Glu Ser Arg Gly Tyr Glu Ile His Met Phe
    2050                2055                2060
Asp Ser Ala Met Asn Ile Thr Ala Tyr Leu Gly Asn Thr Thr Asp Asn
2065                2070                2075                2080
Phe Phe Lys Ile Ser Asn Leu Lys Met Gly His Asn Tyr Thr Phe Thr
                2085                2090                2095
Val Gln Ala Arg Cys Leu Phe Gly Asn Gln Ile Cys Gly Glu Pro Ala
            2100                2105                2110
Ile Leu Leu Tyr Asp Glu Leu Gly Ser Gly Ala Asp Ala Ser Ala Thr
        2115                2120                2125
Gln Ala Ala Arg Ser Thr Asp Val Ala Ala Val Val Val Pro Ile Leu
    2130                2135                2140
Phe Leu Ile Leu Leu Ser Leu Gly Val Gly Phe Ala Ile Leu Tyr Thr
2145                2150                2155                2160
Lys His Arg Arg Leu Gln Ser Ser Phe Thr Ala Phe Ala Asn Ser His
                2165                2170                2175
Tyr Ser Ser Arg Leu Gly Ser Ala Ile Phe Ser Ser Gly Asp Asp Leu
            2180                2185                2190
Gly Glu Asp Asp Glu Asp Ala Pro Met Ile Thr Gly Phe Ser Asp Asp
        2195                2200                2205
Val Pro Met Val Ile Ala
    2210

<210> 813
<211> 2214
<212> PRT
<213> Homo sapiens

<400> 813
Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe
 1               5                  10                  15
Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr
            20                  25                  30
Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe
        35                  40                  45
Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly
    50                  55                  60
Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys
65                  70                  75                  80
Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val
                85                  90                  95
Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu
            100                 105                 110
Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala
        115                 120                 125
Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser
    130                 135                 140
Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser
145                 150                 155                 160
Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg
                165                 170                 175
Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp
            180                 185                 190
Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp
        195                 200                 205
Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg
    210                 215                 220
Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr
225                 230                 235                 240
Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp
                245                 250                 255
Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser
            260                 265                 270
Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu
        275                 280                 285
Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp
    290                 295                 300
Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln
305                 310                 315                 320
Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg
                325                 330                 335
Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala
            340                 345                 350
Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn
        355                 360                 365
Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu
    370                 375                 380
Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp
385                 390                 395                 400
Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg
                405                 410                 415
Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser
            420                 425                 430
Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly
        435                 440                 445
Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys
    450                 455                 460
Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg
465                 470                 475                 480
Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser
                485                 490                 495
Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys
            500                 505                 510
Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala
        515                 520                 525
Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp
    530                 535                 540
His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu
545                 550                 555                 560
Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe
                565                 570                 575
Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu
            580                 585                 590
Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His
        595                 600                 605
Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro
    610                 615                 620
Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly
625                 630                 635                 640
Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro
                645                 650                 655
His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val
            660                 665                 670
Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe
        675                 680                 685
Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu
    690                 695                 700
Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser
705                 710                 715                 720
Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys
                725                 730                 735
Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys
            740                 745                 750
Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser
        755                 760                 765
Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu
    770                 775                 780
Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn
785                 790                 795                 800
Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys
                805                 810                 815
Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu
            820                 825                 830
Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp
        835                 840                 845
Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp
    850                 855                 860
Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala
865                 870                 875                 880
Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly
                885                 890                 895
Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala
            900                 905                 910
Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val
        915                 920                 925
Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu
    930                 935                 940
Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu
945                 950                 955                 960
Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp
                965                 970                 975
Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser
            980                 985                 990
Gln Met Glu Ile Leu Ala Asn Gln Leu Thr Gly Leu Met Asp Met Lys
        995                 1000                1005
Ile Phe Tyr Lys Gly Lys Asn Thr Gly Ser Asn Ala Cys Val Pro Arg
    1010                1015                1020
Pro Cys Ser Leu Leu Cys Leu Pro Lys Ala Asn Asn Ser Arg Ser Cys
1025                1030                1035                1040
Arg Cys Pro Glu Asp Val Ser Ser Ser Val Leu Pro Ser Gly Asp Leu
                1045                1050                1055
Met Cys Asp Cys Pro Gln Gly Tyr Gln Leu Lys Asn Asn Thr Cys Val
            1060                1065                1070
Lys Glu Glu Asn Thr Cys Leu Arg Asn Gln Tyr Arg Cys Ser Asn Gly
        1075                1080                1085
Asn Cys Ile Asn Ser Ile Trp Trp Cys Asp Phe Asp Asn Asp Cys Gly
    1090                1095                1100
Asp Met Ser Asp Glu Arg Asn Cys Pro Thr Thr Ile Cys Asp Leu Asp
1105                1110                1115                1120
Thr Gln Phe Arg Cys Gln Glu Ser Gly Thr Cys Ile Pro Leu Ser Tyr
                1125                1130                1135
Lys Cys Asp Leu Glu Asp Asp Cys Gly Asp Asn Ser Asp Glu Ser His
            1140                1145                1150
Cys Glu Met His Gln Cys Arg Ser Asp Glu Tyr Asn Cys Ser Ser Gly
        1155                1160                1165
Met Cys Ile Arg Ser Ser Trp Val Cys Asp Gly Asp Asn Asp Cys Arg
    1170                1175                1180
Asp Trp Ser Asp Glu Ala Asn Cys Thr Ala Ile Tyr His Thr Cys Glu
1185                1190                1195                1200
Ala Ser Asn Phe Gln Cys Arg Asn Gly His Cys Ile Pro Gln Arg Trp
                1205                1210                1215
Ala Cys Asp Gly Asp Thr Asp Cys Gln Asp Gly Ser Asp Glu Asp Pro
            1220                1225                1230
Val Asn Cys Glu Lys Lys Cys Asn Gly Phe Arg Cys Pro Asn Gly Thr
        1235                1240                1245
Cys Ile Pro Ser Ser Lys His Cys Asp Gly Leu Arg Asp Cys Ser Asp
    1250                1255                1260
Gly Ser Asp Glu Gln His Cys Glu Pro Leu Cys Thr His Phe Met Asp
1265                1270                1275                1280
Phe Val Cys Lys Asn Arg Gln Gln Cys Leu Phe His Ser Met Val Cys
                1285                1290                1295
Asp Gly Ile Ile Gln Cys Arg Asp Gly Ser Asp Glu Asp Ala Ala Phe
            1300                1305                1310
Ala Gly Cys Ser Gln Asp Pro Glu Phe His Lys Val Cys Asp Glu Phe
        1315                1320                1325
Gly Phe Gln Cys Gln Asn Gly Val Cys Ile Ser Leu Ile Trp Lys Cys
    1330                1335                1340
Asp Gly Met Asp Asp Cys Gly Asp Tyr Ser Asp Glu Ala Asn Cys Glu
1345                1350                1355                1360
Asn Pro Thr Glu Ala Pro Asn Cys Ser Arg Tyr Phe Gln Phe Arg Cys
                1365                1370                1375
Glu Asn Gly His Cys Ile Pro Asn Arg Trp Lys Cys Asp Arg Glu Asn
            1380                1385                1390
Asp Cys Gly Asp Trp Ser Asp Glu Lys Asp Cys Gly Asp Ser His Ile
        1395                1400                1405
Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Cys Leu Pro Asn Tyr Tyr
    1410                1415                1420
Arg Cys Ser Ser Gly Thr Cys Val Met Asp Thr Trp Val Cys Asp Gly
1425                1430                1435                1440
Tyr Arg Asp Cys Ala Asp Gly Ser Asp Glu Glu Ala Cys Pro Leu Leu
                1445                1450                1455
Ala Asn Val Thr Ala Ala Ser Thr Pro Thr Gln Leu Gly Arg Cys Asp
            1460                1465                1470
Arg Phe Glu Phe Glu Cys His Gln Pro Lys Thr Cys Ile Pro Asn Trp
        1475                1480                1485
Lys Arg Cys Asp Gly His Gln Asp Cys Gln Asp Gly Arg Asp Glu Ala
    1490                1495                1500
Asn Cys Pro Thr His Ser Thr Leu Thr Cys Met Ser Arg Glu Phe Gln
1505                1510                1515                1520
Cys Glu Asp Gly Glu Ala Cys Ile Val Leu Ser Glu Arg Cys Asp Gly
                1525                1530                1535
Phe Leu Asp Cys Ser Asp Glu Ser Asp Glu Lys Ala Cys Ser Asp Glu
            1540                1545                1550
Leu Thr Val Tyr Lys Val Gln Asn Leu Gln Trp Thr Ala Asp Phe Ser
        1555                1560                1565
Gly Asp Val Thr Leu Thr Trp Met Arg Pro Lys Lys Met Pro Ser Ala
    1570                1575                1580
Ser Cys Val Tyr Asn Val Tyr Tyr Arg Val Val Gly Glu Ser Ile Trp
1585                1590                1595                1600
Lys Thr Leu Glu Thr His Ser Asn Lys Thr Asn Thr Val Leu Lys Val
                1605                1610                1615
Leu Lys Pro Asp Thr Thr Tyr Gln Val Lys Val Gln Val Gln Cys Leu
            1620                1625                1630
Ser Lys Ala His Asn Thr Asn Asp Phe Val Thr Leu Arg Thr Pro Glu
        1635                1640                1645
Gly Leu Pro Asp Ala Pro Arg Asn Leu Gln Leu Ser Leu Pro Arg Glu
    1650                1655                1660
Ala Glu Gly Val Ile Val Gly His Trp Ala Pro Pro Ile His Thr His
1665                1670                1675                1680
Gly Leu Ile Arg Glu Tyr Ile Val Glu Tyr Ser Arg Ser Gly Ser Lys
                1685                1690                1695
Met Trp Ala Ser Gln Arg Ala Ala Ser Asn Phe Thr Glu Ile Lys Asn
            1700                1705                1710
Leu Leu Val Asn Thr Leu Tyr Thr Val Arg Val Ala Ala Val Thr Ser
        1715                1720                1725
Arg Gly Ile Gly Asn Trp Ser Asp Ser Lys Ser Ile Thr Thr Ile Lys
    1730                1735                1740
Gly Lys Val Ile Pro Pro Pro Asp Ile His Ile Asp Ser Tyr Gly Glu
1745                1750                1755                1760
Asn Tyr Leu Ser Phe Thr Leu Thr Met Glu Ser Asp Ile Lys Val Asn
                1765                1770                1775
Gly Tyr Val Val Asn Leu Phe Trp Ala Phe Asp Thr His Lys Gln Glu
            1780                1785                1790
Arg Arg Thr Leu Asn Phe Arg Gly Ser Ile Leu Ser His Lys Val Gly
        1795                1800                1805
Asn Leu Thr Ala His Thr Ser Tyr Glu Ile Ser Ala Trp Ala Lys Thr
    1810                1815                1820
Asp Leu Gly Asp Ser Pro Leu Ala Phe Glu His Val Met Thr Arg Gly
1825                1830                1835                1840
Val Arg Pro Pro Ala Pro Ser Leu Lys Ala Lys Ala Ile Asn Gln Thr
                1845                1850                1855
Ala Val Glu Cys Thr Trp Thr Gly Pro Arg Asn Val Val Tyr Gly Ile
            1860                1865                1870
Phe Tyr Ala Thr Ser Phe Leu Asp Leu Tyr Arg Asn Pro Lys Ser Leu
        1875                1880                1885
Thr Thr Ser Leu His Asn Lys Thr Val Ile Val Ser Lys Asp Glu Gln
    1890                1895                1900
Tyr Leu Phe Leu Val Arg Val Val Val Pro Tyr Gln Gly Pro Ser Ser
1905                1910                1915                1920
Asp Tyr Val Val Val Lys Met Ile Pro Asp Ser Arg Leu Pro Pro Arg
                1925                1930                1935
His Leu His Val Val His Thr Gly Lys Thr Ser Val Val Ile Lys Trp
            1940                1945                1950
Glu Ser Pro Tyr Asp Ser Pro Asp Gln Asp Leu Leu Tyr Ala Ile Ala
        1955                1960                1965
Val Lys Asp Leu Ile Arg Lys Thr Asp Arg Ser Tyr Lys Val Lys Ser
    1970                1975                1980
Arg Asn Ser Thr Val Glu Tyr Thr Leu Asn Lys Leu Glu Pro Gly Gly
1985                1990                1995                2000
Lys Tyr His Ile Ile Val Gln Leu Gly Asn Met Ser Lys Asp Ser Ser
                2005                2010                2015
Ile Lys Ile Thr Thr Val Ser Leu Ser Ala Pro Asp Ala Leu Lys Ile
            2020                2025                2030
Ile Thr Glu Asn Asp His Val Leu Leu Phe Trp Lys Ser Leu Ala Leu
        2035                2040                2045
Lys Glu Lys His Phe Asn Glu Ser Arg Gly Tyr Glu Ile His Met Phe
    2050                2055                2060
Asp Ser Ala Met Asn Ile Thr Ala Tyr Leu Gly Asn Thr Thr Asp Asn
2065                2070                2075                2080
Phe Phe Lys Ile Ser Asn Leu Lys Met Gly His Asn Tyr Thr Phe Thr
                2085                2090                2095
Val Gln Ala Arg Cys Leu Phe Gly Asn Gln Ile Cys Gly Glu Pro Ala
            2100                2105                2110
Ile Leu Leu Tyr Asp Glu Leu Gly Ser Gly Ala Asp Ala Ser Ala Thr
        2115                2120                2125
Gln Ala Ala Arg Ser Thr Asp Val Ala Ala Val Val Val Pro Ile Leu
    2130                2135                2140
Phe Leu Ile Leu Leu Ser Leu Gly Val Gly Phe Ala Ile Leu Tyr Thr
2145                2150                2155                2160
Lys His Arg Arg Leu Gln Ser Ser Phe Thr Ala Phe Ala Asn Ser His
                2165                2170                2175
Tyr Ser Ser Arg Leu Gly Ser Ala Ile Phe Ser Ser Gly Asp Asp Leu
            2180                2185                2190
Gly Glu Asp Asp Glu Asp Ala Pro Met Ile Thr Gly Phe Ser Asp Asp
        2195                2200                2205
Val Pro Met Val Ile Ala
    2210

<210> 814
<211> 2214
<212> PRT
<213> Homo sapiens

<400> 814
Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe
 1               5                  10                  15
Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr
            20                  25                  30
Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe
        35                  40                  45
Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly
    50                  55                  60
Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys
65                  70                  75                  80
Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val
                85                  90                  95
Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu
            100                 105                 110
Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala
        115                 120                 125
Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser
    130                 135                 140
Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser
145                 150                 155                 160
Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg
                165                 170                 175
Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp
            180                 185                 190
Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp
        195                 200                 205
Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg
    210                 215                 220
Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr
225                 230                 235                 240
Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp
                245                 250                 255
Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser
            260                 265                 270
Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu
        275                 280                 285
Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp
    290                 295                 300
Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln
305                 310                 315                 320
Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg
                325                 330                 335
Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala
            340                 345                 350
Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn
        355                 360                 365
Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu
    370                 375                 380
Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp
385                 390                 395                 400
Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg
                405                 410                 415
Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser
            420                 425                 430
Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly
        435                 440                 445
Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys
    450                 455                 460
Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg
465                 470                 475                 480
Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser
                485                 490                 495
Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys
            500                 505                 510
Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala
        515                 520                 525
Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp
    530                 535                 540
His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu
545                 550                 555                 560
Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe
                565                 570                 575
Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu
            580                 585                 590
Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His
        595                 600                 605
Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro
    610                 615                 620
Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly
625                 630                 635                 640
Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro
                645                 650                 655
His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val
            660                 665                 670
Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe
        675                 680                 685
Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu
    690                 695                 700
Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser
705                 710                 715                 720
Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys
                725                 730                 735
Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys
            740                 745                 750
Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser
        755                 760                 765
Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu
    770                 775                 780
Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn
785                 790                 795                 800
Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys
                805                 810                 815
Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu
            820                 825                 830
Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp
        835                 840                 845
Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp
    850                 855                 860
Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala
865                 870                 875                 880
Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly
                885                 890                 895
Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala
            900                 905                 910
Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val
        915                 920                 925
Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu
    930                 935                 940
Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu
945                 950                 955                 960
Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp
                965                 970                 975
Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser
            980                 985                 990
Gln Met Glu Ile Leu Ala Asn Gln Leu Thr Gly Leu Met Asp Met Lys
        995                 1000                1005
Ile Phe Tyr Lys Gly Lys Asn Thr Gly Ser Asn Ala Cys Val Pro Arg
    1010                1015                1020
Pro Cys Ser Leu Leu Cys Leu Pro Lys Ala Asn Asn Ser Arg Ser Cys
1025                1030                1035                1040
Arg Cys Pro Glu Asp Val Ser Ser Ser Val Leu Pro Ser Gly Asp Leu
                1045                1050                1055
Met Cys Asp Cys Pro Gln Gly Tyr Gln Leu Lys Asn Asn Thr Cys Val
            1060                1065                1070
Lys Glu Glu Asn Thr Cys Leu Arg Asn Gln Tyr Arg Cys Ser Asn Gly
        1075                1080                1085
Asn Cys Ile Asn Ser Ile Trp Trp Cys Asp Phe Asp Asn Asp Cys Gly
    1090                1095                1100
Asp Met Ser Asp Glu Arg Asn Cys Pro Thr Thr Ile Cys Asp Leu Asp
1105                1110                1115                1120
Thr Gln Phe Arg Cys Gln Glu Ser Gly Thr Cys Ile Pro Leu Ser Tyr
                1125                1130                1135
Lys Cys Asp Leu Glu Asp Asp Cys Gly Asp Asn Ser Asp Glu Ser His
            1140                1145                1150
Cys Glu Met His Gln Cys Arg Ser Asp Glu Tyr Asn Cys Ser Ser Gly
        1155                1160                1165
Met Cys Ile Arg Ser Ser Trp Val Cys Asp Gly Asp Asn Asp Cys Arg
    1170                1175                1180
Asp Trp Ser Asp Glu Ala Asn Cys Thr Ala Ile Tyr His Thr Cys Glu
1185                1190                1195                1200
Ala Ser Asn Phe Gln Cys Arg Asn Gly His Cys Ile Pro Gln Arg Trp
                1205                1210                1215
Ala Cys Asp Gly Asp Thr Asp Cys Gln Asp Gly Ser Asp Glu Asp Pro
            1220                1225                1230
Val Asn Cys Glu Lys Lys Cys Asn Gly Phe Arg Cys Pro Asn Gly Thr
        1235                1240                1245
Cys Ile Pro Ser Ser Lys His Cys Asp Gly Leu Arg Asp Cys Ser Asp
    1250                1255                1260
Gly Ser Asp Glu Gln His Cys Glu Pro Leu Cys Thr His Phe Met Asp
1265                1270                1275                1280
Phe Val Cys Lys Asn Arg Gln Gln Cys Leu Phe His Ser Met Val Cys
                1285                1290                1295
Asp Gly Ile Ile Gln Cys Arg Asp Gly Ser Asp Glu Asp Ala Ala Phe
            1300                1305                1310
Ala Gly Cys Ser Gln Asp Pro Glu Phe His Lys Val Cys Asp Glu Phe
        1315                1320                1325
Gly Phe Gln Cys Gln Asn Gly Val Cys Ile Ser Leu Ile Trp Lys Cys
    1330                1335                1340
Asp Gly Met Asp Asp Cys Gly Asp Tyr Ser Asp Glu Ala Asn Cys Glu
1345                1350                1355                1360
Asn Pro Thr Glu Ala Pro Asn Cys Ser Arg Tyr Phe Gln Phe Arg Cys
                1365                1370                1375
Glu Asn Gly His Cys Ile Pro Asn Arg Trp Lys Cys Asp Arg Glu Asn
            1380                1385                1390
Asp Cys Gly Asp Trp Ser Asp Glu Lys Asp Cys Gly Asp Ser His Ile
        1395                1400                1405
Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Cys Leu Pro Asn Tyr Tyr
    1410                1415                1420
Arg Cys Ser Ser Gly Thr Cys Val Met Asp Thr Trp Val Cys Asp Gly
1425                1430                1435                1440
Tyr Arg Asp Cys Ala Asp Gly Ser Asp Glu Glu Ala Cys Pro Leu Leu
                1445                1450                1455
Ala Asn Val Thr Ala Ala Ser Thr Pro Thr Gln Leu Gly Arg Cys Asp
            1460                1465                1470
Arg Phe Glu Phe Glu Cys His Gln Pro Lys Thr Cys Ile Pro Asn Trp
        1475                1480                1485
Lys Arg Cys Asp Gly His Gln Asp Cys Gln Asp Gly Arg Asp Glu Ala
    1490                1495                1500
Asn Cys Pro Thr His Ser Thr Leu Thr Cys Met Ser Arg Glu Phe Gln
1505                1510                1515                1520
Cys Glu Asp Gly Glu Ala Cys Ile Val Leu Ser Glu Arg Cys Asp Gly
                1525                1530                1535
Phe Leu Asp Cys Ser Asp Glu Ser Asp Glu Lys Ala Cys Ser Asp Glu
            1540                1545                1550
Leu Thr Val Tyr Lys Val Gln Asn Leu Gln Trp Thr Ala Asp Phe Ser
        1555                1560                1565
Gly Asp Val Thr Leu Thr Trp Met Arg Pro Lys Lys Met Pro Ser Ala
    1570                1575                1580
Ser Cys Val Tyr Asn Val Tyr Tyr Arg Val Val Gly Glu Ser Ile Trp
1585                1590                1595                1600
Lys Thr Leu Glu Thr His Ser Asn Lys Thr Asn Thr Val Leu Lys Val
                1605                1610                1615
Leu Lys Pro Asp Thr Thr Tyr Gln Val Lys Val Gln Val Gln Cys Leu
            1620                1625                1630
Ser Lys Ala His Asn Thr Asn Asp Phe Val Thr Leu Arg Thr Pro Glu
        1635                1640                1645
Gly Leu Pro Asp Ala Pro Arg Asn Leu Gln Leu Ser Leu Pro Arg Glu
    1650                1655                1660
Ala Glu Gly Val Ile Val Gly His Trp Ala Pro Pro Ile His Thr His
1665                1670                1675                1680
Gly Leu Ile Arg Glu Tyr Ile Val Glu Tyr Ser Arg Ser Gly Ser Lys
                1685                1690                1695
Met Trp Ala Ser Gln Arg Ala Ala Ser Asn Phe Thr Glu Ile Lys Asn
            1700                1705                1710
Leu Leu Val Asn Thr Leu Tyr Thr Val Arg Val Ala Ala Val Thr Ser
        1715                1720                1725
Arg Gly Ile Gly Asn Trp Ser Asp Ser Lys Ser Ile Thr Thr Ile Lys
    1730                1735                1740
Gly Lys Val Ile Pro Pro Pro Asp Ile His Ile Asp Ser Tyr Gly Glu
1745                1750                1755                1760
Asn Tyr Leu Ser Phe Thr Leu Thr Met Glu Ser Asp Ile Lys Val Asn
                1765                1770                1775
Gly Tyr Val Val Asn Leu Phe Trp Ala Phe Asp Thr His Lys Gln Glu
            1780                1785                1790
Arg Arg Thr Leu Asn Phe Arg Gly Ser Ile Leu Ser His Lys Val Gly
        1795                1800                1805
Asn Leu Thr Ala His Thr Ser Tyr Glu Ile Ser Ala Trp Ala Lys Thr
    1810                1815                1820
Asp Leu Gly Asp Ser Pro Leu Ala Phe Glu His Val Met Thr Arg Gly
1825                1830                1835                1840
Val Arg Pro Pro Ala Pro Ser Leu Lys Ala Lys Ala Ile Asn Gln Thr
                1845                1850                1855
Ala Val Glu Cys Thr Trp Thr Gly Pro Arg Asn Val Val Tyr Gly Ile
            1860                1865                1870
Phe Tyr Ala Thr Ser Phe Leu Asp Leu Tyr Arg Asn Pro Lys Ser Leu
        1875                1880                1885
Thr Thr Ser Leu His Asn Lys Thr Val Ile Val Ser Lys Asp Glu Gln
    1890                1895                1900
Tyr Leu Phe Leu Val Arg Val Val Val Pro Tyr Gln Gly Pro Ser Ser
1905                1910                1915                1920
Asp Tyr Val Val Val Lys Met Ile Pro Asp Ser Arg Leu Pro Pro Arg
                1925                1930                1935
His Leu His Val Val His Thr Gly Lys Thr Ser Val Val Ile Lys Trp
            1940                1945                1950
Glu Ser Pro Tyr Asp Ser Pro Asp Gln Asp Leu Leu Tyr Ala Ile Ala
        1955                1960                1965
Val Lys Asp Leu Ile Arg Lys Thr Asp Arg Ser Tyr Lys Val Lys Ser
    1970                1975                1980
Arg Asn Ser Thr Val Glu Tyr Thr Leu Asn Lys Leu Glu Pro Gly Gly
1985                1990                1995                2000
Lys Tyr His Ile Ile Val Gln Leu Gly Asn Met Ser Lys Asp Ser Ser
                2005                2010                2015
Ile Lys Ile Thr Thr Val Ser Leu Ser Ala Pro Asp Ala Leu Lys Ile
            2020                2025                2030
Ile Thr Glu Asn Asp His Val Leu Leu Phe Trp Lys Ser Leu Ala Leu
        2035                2040                2045
Lys Glu Lys His Phe Asn Glu Ser Arg Gly Tyr Glu Ile His Met Phe
    2050                2055                2060
Asp Ser Ala Met Asn Ile Thr Ala Tyr Leu Gly Asn Thr Thr Asp Asn
2065                2070                2075                2080
Phe Phe Lys Ile Ser Asn Leu Lys Met Gly His Asn Tyr Thr Phe Thr
                2085                2090                2095
Val Gln Ala Arg Cys Leu Phe Gly Asn Gln Ile Cys Gly Glu Pro Ala
            2100                2105                2110
Ile Leu Leu Tyr Asp Glu Leu Gly Ser Gly Ala Asp Ala Ser Ala Thr
        2115                2120                2125
Gln Ala Ala Arg Ser Thr Asp Val Ala Ala Val Val Val Pro Ile Leu
    2130                2135                2140
Phe Leu Ile Leu Leu Ser Leu Gly Val Gly Phe Ala Ile Leu Tyr Thr
2145                2150                2155                2160
Lys His Arg Arg Leu Gln Ser Ser Phe Thr Ala Phe Ala Asn Ser His
                2165                2170                2175
Tyr Ser Ser Arg Leu Gly Ser Ala Ile Phe Ser Ser Gly Asp Asp Leu
            2180                2185                2190
Gly Glu Asp Asp Glu Asp Ala Pro Met Ile Thr Gly Phe Ser Asp Asp
        2195                2200                2205
Val Pro Met Val Ile Ala
    2210

<210> 815
<211> 180
<212> PRT
<213> Homo sapiens

<400> 815
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 816
<211> 180
<212> PRT
<213> Homo sapiens

<400> 816
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 817
<211> 193
<212> PRT
<213> Homo sapiens

<400> 817
Leu Gln Ala Arg Leu Leu Ser Ala Lys Gly Glu Ile Trp Met Ala Ser
 1               5                  10                  15
Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly Asp Lys Arg
            20                  25                  30
Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu Ile Ile Val
        35                  40                  45
Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala Asn Ser Glu
    50                  55                  60
Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg Asn Val Thr
65                  70                  75                  80
His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly Phe Gln Asp
                85                  90                  95
Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met Ala Leu Met
            100                 105                 110
Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys Val Glu Glu
        115                 120                 125
Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln Asp Ala Ser
    130                 135                 140
Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu Ser Val Arg
145                 150                 155                 160
Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser Ser Ser Ala
                165                 170                 175
Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser Ala Leu Leu
            180                 185                 190
Gln


<210> 818
<211> 180
<212> PRT
<213> Homo sapiens

<400> 818
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 819
<211> 197
<212> PRT
<213> Homo sapiens

<400> 819
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Arg Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala His Cys Asn His Thr Val Met Ala
                85                  90                  95
Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys Val
            100                 105                 110
Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln Asp
        115                 120                 125
Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu Ser
    130                 135                 140
Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser Ser
145                 150                 155                 160
Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser Ser
                165                 170                 175
Ala Ala Val Arg Ser Gln Glu Ala Gly Thr Ser Trp Lys Val Arg Pro
            180                 185                 190
Ala Arg Leu Phe Ala
        195

<210> 820
<211> 180
<212> PRT
<213> Homo sapiens

<400> 820
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 821
<211> 180
<212> PRT
<213> Homo sapiens

<400> 821
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 822
<211> 180
<212> PRT
<213> Homo sapiens

<400> 822
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Gly Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 823
<211> 180
<212> PRT
<213> Homo sapiens

<400> 823
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 824
<211> 180
<212> PRT
<213> Homo sapiens

<400> 824
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 825
<211> 132
<212> PRT
<213> Homo sapiens

<400> 825
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
 1               5                  10                  15
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
            20                  25                  30
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
        35                  40                  45
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
    50                  55                  60
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
65                  70                  75                  80
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
                85                  90                  95
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
            100                 105                 110
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
        115                 120                 125
Ala Leu Leu Gln
    130

<210> 826
<211> 143
<212> PRT
<213> Homo sapiens

<400> 826
Tyr Pro Tyr Asp Val Pro Val Tyr Ala Gly Thr Asn Ser Glu Ala Cys
 1               5                  10                  15
Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg Asn Val Thr His Leu
            20                  25                  30
Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly Phe Gln Asp Val Glu
        35                  40                  45
Ala Gln Ala Ala Thr Cys Asn His Thr Val Met Ala Leu Met Ala Ser
    50                  55                  60
Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys Val Glu Glu Leu Glu
65                  70                  75                  80
Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln Asp Ala Ser Ala Glu
                85                  90                  95
Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu Ser Val Arg Ile Ala
            100                 105                 110
Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser Ser Ser Ala Ala Ala
        115                 120                 125
Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser Ala Leu Leu Gln
    130                 135                 140

<210> 827
<211> 126
<212> PRT
<213> Homo sapiens

<400> 827
Tyr Pro Tyr Asp Val Pro Val Tyr Ala Gly Thr Asn Ser Glu Ala Cys
 1               5                  10                  15
Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg Asn Val Thr His Leu
            20                  25                  30
Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly Phe Gln Asp Val Glu
        35                  40                  45
Ala Gln Ala Ala Thr Cys Asn His Thr Val Met Ala Leu Met Ala Ser
    50                  55                  60
Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys Val Glu Glu Leu Glu
65                  70                  75                  80
Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln Asp Ala Ser Ala Glu
                85                  90                  95
Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu Ser Val Arg Ile Ala
            100                 105                 110
Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser Ser Ser Ala
        115                 120                 125

<210> 828
<211> 180
<212> PRT
<213> Homo sapiens

<400> 828
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 829
<211> 161
<212> PRT
<213> Homo sapiens

<400> 829
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15
Val His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Asn Ser Glu
            20                  25                  30
Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg Asn Val Thr
        35                  40                  45
His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly Phe Gln Asp
    50                  55                  60
Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met Ala Leu Met
65                  70                  75                  80
Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys Val Glu Glu
                85                  90                  95
Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln Asp Ala Ser
            100                 105                 110
Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu Ser Val Arg
        115                 120                 125
Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser Ser Ser Ala
    130                 135                 140
Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser Ala Leu Leu
145                 150                 155                 160
Gln


<210> 830
<211> 147
<212> PRT
<213> Homo sapiens

<400> 830
Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro
 1               5                  10                  15
Gly Ala Arg Cys Ala Tyr Pro Tyr Asp Val Pro Val Tyr Ala Gly Thr
            20                  25                  30
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
        35                  40                  45
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
    50                  55                  60
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
65                  70                  75                  80
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
                85                  90                  95
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
            100                 105                 110
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
        115                 120                 125
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
    130                 135                 140
Ser Ser Ala
145

<210> 831
<211> 180
<212> PRT
<213> Homo sapiens

<400> 831
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 832
<211> 180
<212> PRT
<213> Homo sapiens

<400> 832
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 833
<211> 180
<212> PRT
<213> Homo sapiens

<400> 833
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 834
<211> 180
<212> PRT
<213> Homo sapiens

<400> 834
Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly
 1               5                  10                  15
Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu
            20                  25                  30
Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala
        35                  40                  45
Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg
    50                  55                  60
Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly
65                  70                  75                  80
Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met
                85                  90                  95
Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys
            100                 105                 110
Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln
        115                 120                 125
Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu
    130                 135                 140
Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser
145                 150                 155                 160
Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser
                165                 170                 175
Ala Leu Leu Gln
            180

<210> 835
<211> 595
<212> PRT
<213> Homo sapiens

<400> 835
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 836
<211> 595
<212> PRT
<213> Homo sapiens

<400> 836
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 837
<211> 132
<212> PRT
<213> Homo sapiens

<400> 837
Met Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr
 1               5                  10                  15
Leu Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser
            20                  25                  30
Ser Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn
        35                  40                  45
Asn Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val
    50                  55                  60
Gly Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro
65                  70                  75                  80
Ala Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His
                85                  90                  95
Tyr Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val
            100                 105                 110
Met Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala
        115                 120                 125
Ala Ser Gly Lys
    130

<210> 838
<211> 595
<212> PRT
<213> Homo sapiens

<400> 838
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 839
<211> 595
<212> PRT
<213> Homo sapiens

<400> 839
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 840
<211> 595
<212> PRT
<213> Homo sapiens

<400> 840
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 841
<211> 595
<212> PRT
<213> Homo sapiens

<400> 841
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 842
<211> 595
<212> PRT
<213> Homo sapiens

<400> 842
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 843
<211> 595
<212> PRT
<213> Homo sapiens

<400> 843
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 844
<211> 595
<212> PRT
<213> Homo sapiens

<400> 844
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 845
<211> 595
<212> PRT
<213> Homo sapiens

<400> 845
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu
 1               5                  10                  15
Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn
            20                  25                  30
Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys
        35                  40                  45
Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp
    50                  55                  60
Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg
65                  70                  75                  80
Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr
                85                  90                  95
Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met
            100                 105                 110
Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His
        115                 120                 125
Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln
    130                 135                 140
Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys
145                 150                 155                 160
Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln
                165                 170                 175
Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met
            180                 185                 190
Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu
        195                 200                 205
Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp
    210                 215                 220
Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys
225                 230                 235                 240
Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys
                245                 250                 255
Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro
            260                 265                 270
Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile
        275                 280                 285
Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro
    290                 295                 300
Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys
305                 310                 315                 320
Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn
                325                 330                 335
Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln
            340                 345                 350
Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr
        355                 360                 365
Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala
    370                 375                 380
Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly
385                 390                 395                 400
Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile
                405                 410                 415
Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys
            420                 425                 430
Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg
        435                 440                 445
Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met
    450                 455                 460
Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu
465                 470                 475                 480
Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser
                485                 490                 495
Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn
            500                 505                 510
Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly
        515                 520                 525
Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala
    530                 535                 540
Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr
545                 550                 555                 560
Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met
                565                 570                 575
Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala
            580                 585                 590
Ser Gly Lys
        595

<210> 846
<211> 489
<212> PRT
<213> Homo sapiens

<400> 846
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp
    210                 215                 220
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn
225                 230                 235                 240
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu
                245                 250                 255
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys
            260                 265                 270
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile
        275                 280                 285
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr
    290                 295                 300
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val
305                 310                 315                 320
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr
                325                 330                 335
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile
            340                 345                 350
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly
        355                 360                 365
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser
    370                 375                 380
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg
385                 390                 395                 400
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser
                405                 410                 415
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro
            420                 425                 430
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val
        435                 440                 445
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val
    450                 455                 460
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg
465                 470                 475                 480
Pro Thr Glu Asp Ser Lys Glu Phe Ser
                485

<210> 847
<211> 489
<212> PRT
<213> Homo sapiens

<400> 847
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Gly Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp
    210                 215                 220
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn
225                 230                 235                 240
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu
                245                 250                 255
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys
            260                 265                 270
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile
        275                 280                 285
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr
    290                 295                 300
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val
305                 310                 315                 320
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr
                325                 330                 335
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile
            340                 345                 350
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly
        355                 360                 365
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser
    370                 375                 380
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg
385                 390                 395                 400
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser
                405                 410                 415
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro
            420                 425                 430
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val
        435                 440                 445
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val
    450                 455                 460
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg
465                 470                 475                 480
Pro Thr Glu Asp Ser Lys Glu Phe Ser
                485

<210> 848
<211> 489
<212> PRT
<213> Homo sapiens

<400> 848
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp
    210                 215                 220
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn
225                 230                 235                 240
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu
                245                 250                 255
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys
            260                 265                 270
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile
        275                 280                 285
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr
    290                 295                 300
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val
305                 310                 315                 320
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr
                325                 330                 335
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile
            340                 345                 350
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly
        355                 360                 365
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser
    370                 375                 380
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg
385                 390                 395                 400
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser
                405                 410                 415
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro
            420                 425                 430
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val
        435                 440                 445
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val
    450                 455                 460
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg
465                 470                 475                 480
Pro Thr Glu Asp Ser Lys Glu Phe Ser
                485

<210> 849
<211> 489
<212> PRT
<213> Homo sapiens

<400> 849
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp
    210                 215                 220
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn
225                 230                 235                 240
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu
                245                 250                 255
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys
            260                 265                 270
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile
        275                 280                 285
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr
    290                 295                 300
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val
305                 310                 315                 320
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr
                325                 330                 335
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile
            340                 345                 350
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly
        355                 360                 365
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser
    370                 375                 380
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg
385                 390                 395                 400
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser
                405                 410                 415
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro
            420                 425                 430
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val
        435                 440                 445
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val
    450                 455                 460
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg
465                 470                 475                 480
Pro Thr Glu Asp Ser Lys Glu Phe Ser
                485

<210> 850
<211> 484
<212> PRT
<213> Homo sapiens

<400> 850
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Ser Ala Glu Gly Val Leu His Val Trp Gly
    210                 215                 220
Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn Ser
225                 230                 235                 240
Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Val Leu
                245                 250                 255
Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys Ile Asn Pro Leu Lys
            260                 265                 270
Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile Ser Val Val Arg Ser
        275                 280                 285
Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr Val Ser Leu Ile Thr
    290                 295                 300
Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val Val Cys Glu Glu Pro
305                 310                 315                 320
Leu Ser Pro Ala Thr Val Pro Gly Met His Thr Glu Asp Asn Pro Gly
                325                 330                 335
Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile Thr Glu Val Val Thr
            340                 345                 350
Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly Ser His Leu Thr Pro
        355                 360                 365
Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser Asn Gln Ser Glu Pro
    370                 375                 380
Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg Asn Cys Ser Glu Ser
385                 390                 395                 400
Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser Ser Cys Leu Glu Ser
                405                 410                 415
His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro Asn Asn Lys Gly Glu
            420                 425                 430
Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr
        435                 440                 445
Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val Asp Leu Leu Val Asp
    450                 455                 460
Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg Pro Thr Glu Asp Ser
465                 470                 475                 480
Lys Glu Phe Ser


<210> 851
<211> 184
<212> PRT
<213> Homo sapiens

<400> 851
Ile Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys
 1               5                  10                  15
Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu
            20                  25                  30
Val Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His
        35                  40                  45
Thr Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser
    50                  55                  60
Ile Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro
65                  70                  75                  80
Gly Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser
                85                  90                  95
Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser
            100                 105                 110
Arg Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp
        115                 120                 125
Ser Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro
    130                 135                 140
Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr
145                 150                 155                 160
Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu
                165                 170                 175
Val Asp Leu Leu Val Asp Asp Ser
            180

<210> 852
<211> 184
<212> PRT
<213> Homo sapiens

<400> 852
Ile Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys
 1               5                  10                  15
Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu
            20                  25                  30
Val Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His
        35                  40                  45
Thr Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser
    50                  55                  60
Ile Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro
65                  70                  75                  80
Gly Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser
                85                  90                  95
Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser
            100                 105                 110
Arg Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp
        115                 120                 125
Ser Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro
    130                 135                 140
Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr
145                 150                 155                 160
Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu
                165                 170                 175
Val Asp Leu Leu Val Asp Asp Ser
            180

<210> 853
<211> 184
<212> PRT
<213> Homo sapiens

<400> 853
Ile Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys
 1               5                  10                  15
Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu
            20                  25                  30
Val Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His
        35                  40                  45
Thr Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser
    50                  55                  60
Ile Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro
65                  70                  75                  80
Gly Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser
                85                  90                  95
Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser
            100                 105                 110
Arg Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp
        115                 120                 125
Ser Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro
    130                 135                 140
Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr
145                 150                 155                 160
Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu
                165                 170                 175
Val Asp Leu Leu Val Asp Asp Ser
            180

<210> 854
<211> 184
<212> PRT
<213> Homo sapiens

<400> 854
Ile Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys
 1               5                  10                  15
Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu
            20                  25                  30
Val Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His
        35                  40                  45
Thr Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser
    50                  55                  60
Ile Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro
65                  70                  75                  80
Gly Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser
                85                  90                  95
Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser
            100                 105                 110
Arg Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp
        115                 120                 125
Ser Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro
    130                 135                 140
Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr
145                 150                 155                 160
Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu
                165                 170                 175
Val Asp Leu Leu Val Asp Asp Ser
            180

<210> 855
<211> 184
<212> PRT
<213> Homo sapiens

<400> 855
Ile Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys
 1               5                  10                  15
Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu
            20                  25                  30
Val Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His
        35                  40                  45
Thr Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser
    50                  55                  60
Ile Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro
65                  70                  75                  80
Gly Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser
                85                  90                  95
Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser
            100                 105                 110
Arg Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp
        115                 120                 125
Ser Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro
    130                 135                 140
Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr
145                 150                 155                 160
Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu
                165                 170                 175
Val Asp Leu Leu Val Asp Asp Ser
            180

<210> 856
<211> 489
<212> PRT
<213> Homo sapiens

<400> 856
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met His Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp
    210                 215                 220
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn
225                 230                 235                 240
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu
                245                 250                 255
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys
            260                 265                 270
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile
        275                 280                 285
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr
    290                 295                 300
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val
305                 310                 315                 320
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr
                325                 330                 335
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile
            340                 345                 350
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly
        355                 360                 365
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser
    370                 375                 380
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg
385                 390                 395                 400
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser
                405                 410                 415
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro
            420                 425                 430
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val
        435                 440                 445
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val
    450                 455                 460
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg
465                 470                 475                 480
Pro Thr Glu Asp Ser Lys Glu Phe Ser
                485

<210> 857
<211> 473
<212> PRT
<213> Homo sapiens

<400> 857
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
 1               5                  10                  15
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
            20                  25                  30
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys
        35                  40                  45
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
    50                  55                  60
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
65                  70                  75                  80
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
                85                  90                  95
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
            100                 105                 110
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
        115                 120                 125
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Asp Val Asp
    130                 135                 140
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
145                 150                 155                 160
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
                165                 170                 175
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
            180                 185                 190
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp
        195                 200                 205
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn
    210                 215                 220
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu
225                 230                 235                 240
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys
                245                 250                 255
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile
            260                 265                 270
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr
        275                 280                 285
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val
    290                 295                 300
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr
305                 310                 315                 320
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile
                325                 330                 335
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly
            340                 345                 350
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser
        355                 360                 365
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg
    370                 375                 380
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser
385                 390                 395                 400
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro
                405                 410                 415
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val
            420                 425                 430
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val
        435                 440                 445
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg
    450                 455                 460
Pro Thr Glu Asp Ser Lys Glu Phe Ser
465                 470

<210> 858
<211> 489
<212> PRT
<213> Homo sapiens

<400> 858
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp
    210                 215                 220
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn
225                 230                 235                 240
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu
                245                 250                 255
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys
            260                 265                 270
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile
        275                 280                 285
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr
    290                 295                 300
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val
305                 310                 315                 320
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr
                325                 330                 335
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile
            340                 345                 350
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly
        355                 360                 365
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser
    370                 375                 380
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg
385                 390                 395                 400
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser
                405                 410                 415
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro
            420                 425                 430
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val
        435                 440                 445
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val
    450                 455                 460
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg
465                 470                 475                 480
Pro Thr Glu Asp Ser Lys Glu Phe Ser
                485

<210> 859
<211> 489
<212> PRT
<213> Homo sapiens

<400> 859
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp
    210                 215                 220
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn
225                 230                 235                 240
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu
                245                 250                 255
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys
            260                 265                 270
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile
        275                 280                 285
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr
    290                 295                 300
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val
305                 310                 315                 320
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr
                325                 330                 335
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile
            340                 345                 350
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly
        355                 360                 365
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser
    370                 375                 380
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg
385                 390                 395                 400
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser
                405                 410                 415
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro
            420                 425                 430
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val
        435                 440                 445
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val
    450                 455                 460
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg
465                 470                 475                 480
Pro Thr Glu Asp Ser Lys Glu Phe Ser
                485

<210> 860
<211> 484
<212> PRT
<213> Homo sapiens

<400> 860
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Ser Ala Glu Gly Val Leu His Val Trp Gly
    210                 215                 220
Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn Ser
225                 230                 235                 240
Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Val Leu
                245                 250                 255
Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys Ile Asn Pro Leu Lys
            260                 265                 270
Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile Ser Val Val Arg Ser
        275                 280                 285
Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr Val Ser Leu Ile Thr
    290                 295                 300
Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val Val Cys Glu Glu Pro
305                 310                 315                 320
Leu Ser Pro Ala Thr Val Pro Gly Met His Thr Glu Asp Asn Pro Gly
                325                 330                 335
Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile Thr Glu Val Val Thr
            340                 345                 350
Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly Ser His Leu Thr Pro
        355                 360                 365
Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser Asn Gln Ser Glu Pro
    370                 375                 380
Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg Asn Cys Ser Glu Ser
385                 390                 395                 400
Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser Ser Cys Leu Glu Ser
                405                 410                 415
His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro Asn Asn Lys Gly Glu
            420                 425                 430
Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr
        435                 440                 445
Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val Asp Leu Leu Val Asp
    450                 455                 460
Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg Pro Thr Glu Asp Ser
465                 470                 475                 480
Lys Glu Phe Ser


<210> 861
<211> 489
<212> PRT
<213> Homo sapiens

<400> 861
Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg
 1               5                  10                  15
Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro
            20                  25                  30
Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp
        35                  40                  45
Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Gly Lys
    50                  55                  60
Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile
65                  70                  75                  80
Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn
                85                  90                  95
Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala
            100                 105                 110
Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly
        115                 120                 125
Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp
    130                 135                 140
Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp
145                 150                 155                 160
Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val
                165                 170                 175
Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu
            180                 185                 190
Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser
        195                 200                 205
Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp
    210                 215                 220
Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn
225                 230                 235                 240
Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu
                245                 250                 255
Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys
            260                 265                 270
Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile
        275                 280                 285
Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr
    290                 295                 300
Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val
305                 310                 315                 320
Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr
                325                 330                 335
Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile
            340                 345                 350
Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly
        355                 360                 365
Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser
    370                 375                 380
Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg
385                 390                 395                 400
Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser
                405                 410                 415
Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro
            420                 425                 430
Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val
        435                 440                 445
Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val
    450                 455                 460
Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg
465                 470                 475                 480
Pro Thr Glu Asp Ser Lys Glu Phe Ser
                485

<210> 862
<211> 1299
<212> PRT
<213> Homo sapiens

<400> 862
Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg Val Pro Leu Ile Leu
 1               5                  10                  15
Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val Pro Leu Asp Pro Lys
            20                  25                  30
Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro
        35                  40                  45
Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu
    50                  55                  60
Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr
65                  70                  75                  80
His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr
                85                  90                  95
Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr
            100                 105                 110
Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val
        115                 120                 125
Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys
    130                 135                 140
Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu
145                 150                 155                 160
Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met
                165                 170                 175
Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly
            180                 185                 190
Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg
        195                 200                 205
Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln
    210                 215                 220
Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn
225                 230                 235                 240
Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys
                245                 250                 255
Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala
            260                 265                 270
Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile
        275                 280                 285
Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly
    290                 295                 300
Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu
305                 310                 315                 320
Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile
                325                 330                 335
Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val
            340                 345                 350
Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser
        355                 360                 365
Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys
    370                 375                 380
Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro
385                 390                 395                 400
Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn
                405                 410                 415
Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu
            420                 425                 430
Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro
        435                 440                 445
Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile Ala Asn
    450                 455                 460
Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu Pro Thr
465                 470                 475                 480
Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu Asp Ile
                485                 490                 495
Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Lys Asp Ala Thr Trp
            500                 505                 510
Ile Val Lys Glu Ile Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr
        515                 520                 525
Thr Cys Val Ala Arg Asn Lys Leu Gly Met Ala Lys Asn Glu Val His
    530                 535                 540
Leu Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val Ser Phe
545                 550                 555                 560
Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val Leu Trp
                565                 570                 575
Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr Val Asp
            580                 585                 590
Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser Gly Thr
        595                 600                 605
Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala Ser Ala
    610                 615                 620
Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val Tyr Asp
625                 630                 635                 640
Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu Asp Lys
                645                 650                 655
Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser Pro Ile
            660                 665                 670
Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro Gly Leu
        675                 680                 685
Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala Gln Leu
    690                 695                 700
Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala Val Asn
705                 710                 715                 720
Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr Leu Thr
                725                 730                 735
Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly Leu Gly
            740                 745                 750
Ser Glu Pro Asp Asn Leu Glu Ile Thr Trp Lys Pro Leu Asn Gly Phe
        755                 760                 765
Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg Gln Lys
    770                 775                 780
Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val Ser Lys
785                 790                 795                 800
Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile Lys Val
                805                 810                 815
Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val Val Met
            820                 825                 830
Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn Val Arg
        835                 840                 845
Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp Pro Val
    850                 855                 860
Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile Tyr Tyr
865                 870                 875                 880
Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile Glu Lys
                885                 890                 895
Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu Pro Gly
            900                 905                 910
Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val Asn Gly
        915                 920                 925
Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr Pro Glu
    930                 935                 940
Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro Thr Leu
945                 950                 955                 960
Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn Gly Ile
                965                 970                 975
Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr His Glu
            980                 985                 990
Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr Arg Trp
        995                 1000                1005
Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr Phe Tyr
    1010                1015                1020
Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu Ala Val
1025                1030                1035                1040
Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro Asp Val Gly Ala Gly
                1045                1050                1055
Lys Val Gln Ala Val Asn Thr Arg Ile Ser Asn Leu Thr Ala Ala Ala
            1060                1065                1070
Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr Glu Gly Pro Glu His
        1075                1080                1085
Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly Ser Lys Glu Glu Trp
    1090                1095                1100
Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe Phe Gly Leu Lys Gly
1105                1110                1115                1120
Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val Gly Ala Val Gly Asp
                1125                1130                1135
Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu Thr Gly Pro Ala Met
            1140                1145                1150
Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu
        1155                1160                1165
Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu Leu Ile Val Cys Phe
    1170                1175                1180
Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val Lys Glu Lys Glu Asp
1185                1190                1195                1200
Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys Glu Asp Asp Gly Thr
                1205                1210                1215
Phe Gly Glu Tyr Ser Asp Ala Glu Asp His Lys Pro Leu Lys Lys Gly
            1220                1225                1230
Ser Arg Thr Pro Ser Asp Arg Thr Val Lys Lys Glu Asp Ser Asp Asp
        1235                1240                1245
Ser Leu Val Asp Tyr Gly Glu Gly Val Asn Gly Gln Phe Asn Glu Asp
    1250                1255                1260
Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu Pro Ala
1265                1270                1275                1280
Glu Gly Asn Glu Ser Ser Glu Ala Pro Ser Pro Val Asn Ala Met Asn
                1285                1290                1295
Ser Phe Val


<210> 863
<211> 1180
<212> PRT
<213> Homo sapiens

<400> 863
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly
                245                 250                 255
Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu
            260                 265                 270
Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu
        275                 280                 285
Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys
    290                 295                 300
Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln
305                 310                 315                 320
Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val
                325                 330                 335
Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val
            340                 345                 350
Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn
        355                 360                 365
Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile
    370                 375                 380
Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe
385                 390                 395                 400
Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser
                405                 410                 415
Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala
            420                 425                 430
Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile
        435                 440                 445
Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu
    450                 455                 460
Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu
465                 470                 475                 480
Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala
                485                 490                 495
Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu
            500                 505                 510
Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Ala Thr Trp
        515                 520                 525
Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val
    530                 535                 540
Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val
545                 550                 555                 560
Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr
                565                 570                 575
Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser
            580                 585                 590
Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala
        595                 600                 605
Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val
    610                 615                 620
Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu
625                 630                 635                 640
Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser
                645                 650                 655
Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro
            660                 665                 670
Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala
        675                 680                 685
Gln Leu Asn Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala
    690                 695                 700
Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr
705                 710                 715                 720
Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly
                725                 730                 735
Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn
            740                 745                 750
Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg
        755                 760                 765
Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val
    770                 775                 780
Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile
785                 790                 795                 800
Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val
                805                 810                 815
Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn
            820                 825                 830
Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp
        835                 840                 845
Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile
    850                 855                 860
Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile
865                 870                 875                 880
Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu
                885                 890                 895
Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val
            900                 905                 910
Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr
        915                 920                 925
Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro
    930                 935                 940
Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn
945                 950                 955                 960
Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr
                965                 970                 975
His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr
            980                 985                 990
Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr
        995                 1000                1005
Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu
    1010                1015                1020
Ala Val Thr Thr Val Asp Glu Ala Met Ala Ser Arg Gln Val Asp Ile
1025                1030                1035                1040
Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu
                1045                1050                1055
Ile Leu Ile Leu Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly
            1060                1065                1070
Lys Tyr Pro Val Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile
        1075                1080                1085
Gln Pro Met Lys Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala
    1090                1095                1100
Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg
1105                1110                1115                1120
Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu
                1125                1130                1135
Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr
            1140                1145                1150
Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu
        1155                1160                1165
Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val
    1170                1175                1180

<210> 864
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 864
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu
                245                 250                 255
Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr
            260                 265                 270
Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu
        275                 280                 285
Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp
    290                 295                 300
Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn
305                 310                 315                 320
Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly
                325                 330                 335
Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr
            340                 345                 350
Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln
        355                 360                 365
Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala
    370                 375                 380
Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro
385                 390                 395                 400
Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr
                405                 410                 415
Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys
            420                 425                 430
Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn
        435                 440                 445
Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr
    450                 455                 460
Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly
465                 470                 475                 480
Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala
                485                 490                 495
Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile
            500                 505                 510
Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg
        515                 520                 525
Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp
    530                 535                 540
Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly
545                 550                 555                 560
Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser
                565                 570                 575
Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu
            580                 585                 590
Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp
        595                 600                 605
Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser
    610                 615                 620
Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro
625                 630                 635                 640
Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr
                645                 650                 655
Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp
            660                 665                 670
Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met
        675                 680                 685
His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln
    690                 695                 700
Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg
705                 710                 715                 720
Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser
                725                 730                 735
Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala
            740                 745                 750
Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys
        755                 760                 765
Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val
    770                 775                 780
Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val
785                 790                 795                 800
Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro
                805                 810                 815
Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu
            820                 825                 830
Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala
        835                 840                 845
Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val
    850                 855                 860
His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly
865                 870                 875                 880
Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg
                885                 890                 895
Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His
            900                 905                 910
Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val
        915                 920                 925
Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val
    930                 935                 940
Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile
945                 950                 955                 960
Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser
                965                 970                 975
His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile
            980                 985                 990
Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala
        995                 1000                1005
Asn Lys Thr Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr
    1010                1015                1020
Lys Phe Tyr Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile
1025                1030                1035                1040
Thr Glu Glu Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro
                1045                1050                1055
Asp Val Gly Ala Gly Lys Val Gln Ala Val Asn Pro Arg Ile Ser Asn
            1060                1065                1070
Leu Thr Ala Ala Ala Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr
        1075                1080                1085
Glu Gly Pro Glu His Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly
    1090                1095                1100
Ser Lys Glu Glu Trp Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe
1105                1110                1115                1120
Phe Gly Leu Lys Gly Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val
                1125                1130                1135
Gly Ala Val Gly Asp Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu
            1140                1145                1150
Thr Gly Pro Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly
        1155                1160                1165
Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu
    1170                1175                1180
Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val
1185                1190                1195                1200
Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys
                1205                1210                1215
Glu Asp Asp Gly Thr Phe Gly Glu Tyr Arg Ser Leu Glu Ser Asp Ala
            1220                1225                1230
Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg
        1235                1240                1245
Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu
    1250                1255                1260
Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr
1265                1270                1275                1280
Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu
                1285                1290                1295
Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val
            1300                1305

<210> 865
<211> 1236
<212> PRT
<213> Homo sapiens

<400> 865
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu
                245                 250                 255
Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr
            260                 265                 270
Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu
        275                 280                 285
Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp
    290                 295                 300
Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn
305                 310                 315                 320
Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly
                325                 330                 335
Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr
            340                 345                 350
Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln
        355                 360                 365
Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala
    370                 375                 380
Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro
385                 390                 395                 400
Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr
                405                 410                 415
Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys
            420                 425                 430
Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn
        435                 440                 445
Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr
    450                 455                 460
Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly
465                 470                 475                 480
Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala
                485                 490                 495
Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile
            500                 505                 510
Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg
        515                 520                 525
Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp
    530                 535                 540
Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly
545                 550                 555                 560
Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser
                565                 570                 575
Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu
            580                 585                 590
Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp
        595                 600                 605
Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser
    610                 615                 620
Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro
625                 630                 635                 640
Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr
                645                 650                 655
Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp
            660                 665                 670
Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met
        675                 680                 685
His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln
    690                 695                 700
Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg
705                 710                 715                 720
Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser
                725                 730                 735
Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala
            740                 745                 750
Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys
        755                 760                 765
Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val
    770                 775                 780
Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val
785                 790                 795                 800
Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro
                805                 810                 815
Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu
            820                 825                 830
Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala
        835                 840                 845
Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val
    850                 855                 860
His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly
865                 870                 875                 880
Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg
                885                 890                 895
Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His
            900                 905                 910
Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val
        915                 920                 925
Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val
    930                 935                 940
Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile
945                 950                 955                 960
Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser
                965                 970                 975
His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile
            980                 985                 990
Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala
        995                 1000                1005
Asn Lys Thr Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr
    1010                1015                1020
Lys Phe Tyr Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile
1025                1030                1035                1040
Thr Glu Glu Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro
                1045                1050                1055
Asp Val Gly Ala Gly Lys Val Gln Ala Val Asn Pro Arg Ile Ser Asn
            1060                1065                1070
Leu Thr Ala Ala Ala Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr
        1075                1080                1085
Glu Gly Pro Glu His Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly
    1090                1095                1100
Ser Lys Glu Glu Trp Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe
1105                1110                1115                1120
Phe Gly Leu Lys Gly Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val
                1125                1130                1135
Gly Ala Val Gly Asp Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu
            1140                1145                1150
Thr Gly Pro Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly
        1155                1160                1165
Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu
    1170                1175                1180
Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val
1185                1190                1195                1200
Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys
                1205                1210                1215
Glu Asp Asp Gly Thr Phe Gly Glu Tyr Arg Leu Phe Ser Phe Val Ser
            1220                1225                1230
Ser Ala Ser Phe
        1235

<210> 866
<211> 1192
<212> PRT
<213> Homo sapiens

<400> 866
Met Gln Leu Asn Ile Met Pro Thr Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly
                245                 250                 255
Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu
            260                 265                 270
Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu
        275                 280                 285
Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys
    290                 295                 300
Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln
305                 310                 315                 320
Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val
                325                 330                 335
Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val
            340                 345                 350
Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn
        355                 360                 365
Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile
    370                 375                 380
Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe
385                 390                 395                 400
Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser
                405                 410                 415
Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala
            420                 425                 430
Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile
        435                 440                 445
Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu
    450                 455                 460
Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu
465                 470                 475                 480
Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala
                485                 490                 495
Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu
            500                 505                 510
Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Ala Thr Trp
        515                 520                 525
Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val
    530                 535                 540
Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val
545                 550                 555                 560
Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr
                565                 570                 575
Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser
            580                 585                 590
Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala
        595                 600                 605
Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val
    610                 615                 620
Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu
625                 630                 635                 640
Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser
                645                 650                 655
Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro
            660                 665                 670
Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala
        675                 680                 685
Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala
    690                 695                 700
Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr
705                 710                 715                 720
Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly
                725                 730                 735
Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn
            740                 745                 750
Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg
        755                 760                 765
Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val
    770                 775                 780
Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile
785                 790                 795                 800
Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val
                805                 810                 815
Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn
            820                 825                 830
Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp
        835                 840                 845
Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile
    850                 855                 860
Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile
865                 870                 875                 880
Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu
                885                 890                 895
Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val
            900                 905                 910
Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr
        915                 920                 925
Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro
    930                 935                 940
Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn
945                 950                 955                 960
Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr
                965                 970                 975
His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr
            980                 985                 990
Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr
        995                 1000                1005
Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu
    1010                1015                1020
Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro Asp Val Gly
1025                1030                1035                1040
Ala Gly Lys Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly
                1045                1050                1055
Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu
            1060                1065                1070
Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val
        1075                1080                1085
Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys
    1090                1095                1100
Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala Glu Asp His Lys
1105                1110                1115                1120
Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg Thr Val Lys Lys
                1125                1130                1135
Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Val Asn Gly
            1140                1145                1150
Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys
        1155                1160                1165
Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu Ala Pro Ser Pro
    1170                1175                1180
Val Asn Ala Met Asn Ser Phe Val
1185                1190

<210> 867
<211> 1192
<212> PRT
<213> Homo sapiens

<400> 867
Met Gln Leu Asn Ile Met Pro Thr Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly
                245                 250                 255
Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu
            260                 265                 270
Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu
        275                 280                 285
Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys
    290                 295                 300
Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln
305                 310                 315                 320
Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val
                325                 330                 335
Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val
            340                 345                 350
Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn
        355                 360                 365
Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile
    370                 375                 380
Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe
385                 390                 395                 400
Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser
                405                 410                 415
Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala
            420                 425                 430
Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile
        435                 440                 445
Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu
    450                 455                 460
Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu
465                 470                 475                 480
Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala
                485                 490                 495
Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu
            500                 505                 510
Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Ala Thr Trp
        515                 520                 525
Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val
    530                 535                 540
Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val
545                 550                 555                 560
Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr
                565                 570                 575
Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser
            580                 585                 590
Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala
        595                 600                 605
Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val
    610                 615                 620
Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu
625                 630                 635                 640
Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser
                645                 650                 655
Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro
            660                 665                 670
Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala
        675                 680                 685
Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala
    690                 695                 700
Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr
705                 710                 715                 720
Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly
                725                 730                 735
Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn
            740                 745                 750
Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg
        755                 760                 765
Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val
    770                 775                 780
Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile
785                 790                 795                 800
Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val
                805                 810                 815
Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn
            820                 825                 830
Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp
        835                 840                 845
Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile
    850                 855                 860
Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile
865                 870                 875                 880
Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu
                885                 890                 895
Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val
            900                 905                 910
Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr
        915                 920                 925
Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro
    930                 935                 940
Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn
945                 950                 955                 960
Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr
                965                 970                 975
His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr
            980                 985                 990
Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr
        995                 1000                1005
Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu
    1010                1015                1020
Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro Asp Val Gly
1025                1030                1035                1040
Ala Gly Lys Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly
                1045                1050                1055
Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu
            1060                1065                1070
Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val
        1075                1080                1085
Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys
    1090                1095                1100
Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala Glu Asp His Lys
1105                1110                1115                1120
Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg Thr Val Lys Lys
                1125                1130                1135
Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Val Asn Gly
            1140                1145                1150
Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys
        1155                1160                1165
Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu Ala Pro Ser Pro
    1170                1175                1180
Val Asn Ala Met Asn Ser Phe Val
1185                1190

<210> 868
<211> 1192
<212> PRT
<213> Homo sapiens

<400> 868
Met Gln Leu Asn Ile Met Pro Thr Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly
                245                 250                 255
Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu
            260                 265                 270
Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu
        275                 280                 285
Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys
    290                 295                 300
Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln
305                 310                 315                 320
Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val
                325                 330                 335
Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val
            340                 345                 350
Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn
        355                 360                 365
Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile
    370                 375                 380
Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe
385                 390                 395                 400
Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser
                405                 410                 415
Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala
            420                 425                 430
Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile
        435                 440                 445
Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu
    450                 455                 460
Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu
465                 470                 475                 480
Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala
                485                 490                 495
Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu
            500                 505                 510
Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Ala Thr Trp
        515                 520                 525
Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val
    530                 535                 540
Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val
545                 550                 555                 560
Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr
                565                 570                 575
Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser
            580                 585                 590
Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala
        595                 600                 605
Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val
    610                 615                 620
Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu
625                 630                 635                 640
Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser
                645                 650                 655
Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro
            660                 665                 670
Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala
        675                 680                 685
Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala
    690                 695                 700
Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr
705                 710                 715                 720
Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly
                725                 730                 735
Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn
            740                 745                 750
Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg
        755                 760                 765
Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val
    770                 775                 780
Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile
785                 790                 795                 800
Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val
                805                 810                 815
Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn
            820                 825                 830
Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp
        835                 840                 845
Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile
    850                 855                 860
Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile
865                 870                 875                 880
Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu
                885                 890                 895
Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val
            900                 905                 910
Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr
        915                 920                 925
Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro
    930                 935                 940
Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn
945                 950                 955                 960
Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr
                965                 970                 975
His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr
            980                 985                 990
Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr
        995                 1000                1005
Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu
    1010                1015                1020
Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro Asp Val Gly
1025                1030                1035                1040
Ala Gly Lys Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly
                1045                1050                1055
Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu
            1060                1065                1070
Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val
        1075                1080                1085
Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys
    1090                1095                1100
Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala Glu Asp His Lys
1105                1110                1115                1120
Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg Thr Val Lys Lys
                1125                1130                1135
Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Val Asn Gly
            1140                1145                1150
Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys
        1155                1160                1165
Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu Ala Pro Ser Pro
    1170                1175                1180
Val Asn Ala Met Asn Ser Phe Val
1185                1190

<210> 869
<211> 1299
<212> PRT
<213> Homo sapiens

<400> 869
Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg Val Pro Leu Ile Leu
 1               5                  10                  15
Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val Pro Leu Asp Pro Lys
            20                  25                  30
Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro
        35                  40                  45
Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu
    50                  55                  60
Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr
65                  70                  75                  80
His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr
                85                  90                  95
Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr
            100                 105                 110
Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val
        115                 120                 125
Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys
    130                 135                 140
Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu
145                 150                 155                 160
Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met
                165                 170                 175
Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly
            180                 185                 190
Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg
        195                 200                 205
Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln
    210                 215                 220
Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn
225                 230                 235                 240
Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys
                245                 250                 255
Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala
            260                 265                 270
Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile
        275                 280                 285
Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly
    290                 295                 300
Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu
305                 310                 315                 320
Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile
                325                 330                 335
Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val
            340                 345                 350
Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser
        355                 360                 365
Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys
    370                 375                 380
Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro
385                 390                 395                 400
Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn
                405                 410                 415
Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu
            420                 425                 430
Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro
        435                 440                 445
Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile Ala Asn
    450                 455                 460
Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu Pro Thr
465                 470                 475                 480
Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu Asp Ile
                485                 490                 495
Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Lys Asp Ala Thr Trp
            500                 505                 510
Ile Val Lys Glu Ile Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr
        515                 520                 525
Thr Cys Val Ala Arg Asn Lys Leu Gly Met Ala Lys Asn Glu Val His
    530                 535                 540
Leu Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val Ser Phe
545                 550                 555                 560
Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val Leu Trp
                565                 570                 575
Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr Val Asp
            580                 585                 590
Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser Gly Thr
        595                 600                 605
Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala Ser Ala
    610                 615                 620
Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val Tyr Asp
625                 630                 635                 640
Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu Asp Lys
                645                 650                 655
Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser Pro Ile
            660                 665                 670
Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro Gly Leu
        675                 680                 685
Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala Gln Leu
    690                 695                 700
Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala Val Asn
705                 710                 715                 720
Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr Leu Thr
                725                 730                 735
Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly Leu Gly
            740                 745                 750
Ser Glu Pro Asp Asn Leu Glu Ile Thr Trp Lys Pro Leu Asn Gly Phe
        755                 760                 765
Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg Gln Lys
    770                 775                 780
Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val Ser Lys
785                 790                 795                 800
Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile Lys Val
                805                 810                 815
Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val Val Met
            820                 825                 830
Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn Val Arg
        835                 840                 845
Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp Pro Val
    850                 855                 860
Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile Tyr Tyr
865                 870                 875                 880
Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile Glu Lys
                885                 890                 895
Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu Pro Gly
            900                 905                 910
Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val Asn Gly
        915                 920                 925
Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr Pro Glu
    930                 935                 940
Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro Thr Leu
945                 950                 955                 960
Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn Gly Ile
                965                 970                 975
Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr His Glu
            980                 985                 990
Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr Arg Trp
        995                 1000                1005
Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr Phe Tyr
    1010                1015                1020
Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu Ala Val
1025                1030                1035                1040
Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro Asp Val Gly Ala Gly
                1045                1050                1055
Lys Val Gln Ala Val Asn Thr Arg Ile Ser Asn Leu Thr Ala Ala Ala
            1060                1065                1070
Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr Glu Gly Pro Glu His
        1075                1080                1085
Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly Ser Lys Glu Glu Trp
    1090                1095                1100
Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe Phe Gly Leu Lys Gly
1105                1110                1115                1120
Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val Gly Ala Val Gly Asp
                1125                1130                1135
Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu Thr Gly Pro Ala Met
            1140                1145                1150
Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu
        1155                1160                1165
Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu Leu Ile Val Cys Phe
    1170                1175                1180
Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val Lys Glu Lys Glu Asp
1185                1190                1195                1200
Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys Glu Asp Asp Gly Thr
                1205                1210                1215
Phe Gly Glu Tyr Ser Asp Ala Glu Asp His Lys Pro Leu Lys Lys Gly
            1220                1225                1230
Ser Arg Thr Pro Ser Asp Arg Thr Val Lys Lys Glu Asp Ser Asp Asp
        1235                1240                1245
Ser Leu Val Asp Tyr Gly Glu Gly Val Asn Gly Gln Phe Asn Glu Asp
    1250                1255                1260
Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu Pro Ala
1265                1270                1275                1280
Glu Gly Asn Glu Ser Ser Glu Ala Pro Ser Pro Val Asn Ala Met Asn
                1285                1290                1295
Ser Phe Val


<210> 870
<211> 1180
<212> PRT
<213> Homo sapiens

<400> 870
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly
                245                 250                 255
Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu
            260                 265                 270
Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu
        275                 280                 285
Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys
    290                 295                 300
Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln
305                 310                 315                 320
Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val
                325                 330                 335
Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val
            340                 345                 350
Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn
        355                 360                 365
Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile
    370                 375                 380
Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe
385                 390                 395                 400
Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser
                405                 410                 415
Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala
            420                 425                 430
Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile
        435                 440                 445
Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu
    450                 455                 460
Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu
465                 470                 475                 480
Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala
                485                 490                 495
Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu
            500                 505                 510
Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Ala Thr Trp
        515                 520                 525
Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val
    530                 535                 540
Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val
545                 550                 555                 560
Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr
                565                 570                 575
Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser
            580                 585                 590
Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala
        595                 600                 605
Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val
    610                 615                 620
Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu
625                 630                 635                 640
Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser
                645                 650                 655
Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro
            660                 665                 670
Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala
        675                 680                 685
Gln Leu Asn Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala
    690                 695                 700
Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr
705                 710                 715                 720
Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly
                725                 730                 735
Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn
            740                 745                 750
Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg
        755                 760                 765
Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val
    770                 775                 780
Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile
785                 790                 795                 800
Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val
                805                 810                 815
Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn
            820                 825                 830
Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp
        835                 840                 845
Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile
    850                 855                 860
Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile
865                 870                 875                 880
Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu
                885                 890                 895
Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val
            900                 905                 910
Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr
        915                 920                 925
Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro
    930                 935                 940
Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn
945                 950                 955                 960
Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr
                965                 970                 975
His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr
            980                 985                 990
Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr
        995                 1000                1005
Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu
    1010                1015                1020
Ala Val Thr Thr Val Asp Glu Ala Met Ala Ser Arg Gln Val Asp Ile
1025                1030                1035                1040
Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu
                1045                1050                1055
Ile Leu Ile Leu Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly
            1060                1065                1070
Lys Tyr Pro Val Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile
        1075                1080                1085
Gln Pro Met Lys Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala
    1090                1095                1100
Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg
1105                1110                1115                1120
Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu
                1125                1130                1135
Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr
            1140                1145                1150
Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu
        1155                1160                1165
Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val
    1170                1175                1180

<210> 871
<211> 1180
<212> PRT
<213> Homo sapiens

<400> 871
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly
                245                 250                 255
Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu
            260                 265                 270
Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu
        275                 280                 285
Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys
    290                 295                 300
Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln
305                 310                 315                 320
Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val
                325                 330                 335
Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val
            340                 345                 350
Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn
        355                 360                 365
Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile
    370                 375                 380
Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe
385                 390                 395                 400
Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser
                405                 410                 415
Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala
            420                 425                 430
Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile
        435                 440                 445
Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu
    450                 455                 460
Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu
465                 470                 475                 480
Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala
                485                 490                 495
Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu
            500                 505                 510
Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Ala Thr Trp
        515                 520                 525
Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val
    530                 535                 540
Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val
545                 550                 555                 560
Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr
                565                 570                 575
Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser
            580                 585                 590
Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala
        595                 600                 605
Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val
    610                 615                 620
Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu
625                 630                 635                 640
Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser
                645                 650                 655
Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro
            660                 665                 670
Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala
        675                 680                 685
Gln Leu Asn Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala
    690                 695                 700
Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr
705                 710                 715                 720
Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly
                725                 730                 735
Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn
            740                 745                 750
Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg
        755                 760                 765
Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val
    770                 775                 780
Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile
785                 790                 795                 800
Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val
                805                 810                 815
Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn
            820                 825                 830
Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp
        835                 840                 845
Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile
    850                 855                 860
Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile
865                 870                 875                 880
Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu
                885                 890                 895
Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val
            900                 905                 910
Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr
        915                 920                 925
Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro
    930                 935                 940
Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn
945                 950                 955                 960
Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr
                965                 970                 975
His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr
            980                 985                 990
Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr
        995                 1000                1005
Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu
    1010                1015                1020
Ala Val Thr Thr Val Asp Glu Ala Met Ala Ser Arg Gln Val Asp Ile
1025                1030                1035                1040
Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu
                1045                1050                1055
Ile Leu Ile Leu Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly
            1060                1065                1070
Lys Tyr Pro Val Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile
        1075                1080                1085
Gln Pro Met Lys Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala
    1090                1095                1100
Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg
1105                1110                1115                1120
Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu
                1125                1130                1135
Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr
            1140                1145                1150
Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu
        1155                1160                1165
Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val
    1170                1175                1180

<210> 872
<211> 1299
<212> PRT
<213> Homo sapiens

<400> 872
Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg Val Pro Leu Ile Leu
 1               5                  10                  15
Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val Pro Leu Asp Pro Lys
            20                  25                  30
Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro
        35                  40                  45
Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu
    50                  55                  60
Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr
65                  70                  75                  80
His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr
                85                  90                  95
Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr
            100                 105                 110
Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val
        115                 120                 125
Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys
    130                 135                 140
Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu
145                 150                 155                 160
Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met
                165                 170                 175
Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly
            180                 185                 190
Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg
        195                 200                 205
Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln
    210                 215                 220
Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn
225                 230                 235                 240
Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys
                245                 250                 255
Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala
            260                 265                 270
Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile
        275                 280                 285
Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly
    290                 295                 300
Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu
305                 310                 315                 320
Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile
                325                 330                 335
Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val
            340                 345                 350
Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser
        355                 360                 365
Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys
    370                 375                 380
Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro
385                 390                 395                 400
Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn
                405                 410                 415
Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu
            420                 425                 430
Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro
        435                 440                 445
Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile Ala Asn
    450                 455                 460
Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu Pro Thr
465                 470                 475                 480
Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu Asp Ile
                485                 490                 495
Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Lys Asp Ala Thr Trp
            500                 505                 510
Ile Val Lys Glu Ile Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr
        515                 520                 525
Thr Cys Val Ala Arg Asn Lys Leu Gly Met Ala Lys Asn Glu Val His
    530                 535                 540
Leu Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val Ser Phe
545                 550                 555                 560
Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val Leu Trp
                565                 570                 575
Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr Val Asp
            580                 585                 590
Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser Gly Thr
        595                 600                 605
Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala Ser Ala
    610                 615                 620
Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val Tyr Asp
625                 630                 635                 640
Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu Asp Lys
                645                 650                 655
Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser Pro Ile
            660                 665                 670
Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro Gly Leu
        675                 680                 685
Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala Gln Leu
    690                 695                 700
Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala Val Asn
705                 710                 715                 720
Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr Leu Thr
                725                 730                 735
Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly Leu Gly
            740                 745                 750
Ser Glu Pro Asp Asn Leu Glu Ile Thr Trp Lys Pro Leu Asn Gly Phe
        755                 760                 765
Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg Gln Lys
    770                 775                 780
Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val Ser Lys
785                 790                 795                 800
Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile Lys Val
                805                 810                 815
Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val Val Met
            820                 825                 830
Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn Val Arg
        835                 840                 845
Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp Pro Val
    850                 855                 860
Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile Tyr Tyr
865                 870                 875                 880
Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile Glu Lys
                885                 890                 895
Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu Pro Gly
            900                 905                 910
Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val Asn Gly
        915                 920                 925
Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr Pro Glu
    930                 935                 940
Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro Thr Leu
945                 950                 955                 960
Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn Gly Ile
                965                 970                 975
Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr His Glu
            980                 985                 990
Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr Arg Trp
        995                 1000                1005
Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr Phe Tyr
    1010                1015                1020
Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu Ala Val
1025                1030                1035                1040
Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro Asp Val Gly Ala Gly
                1045                1050                1055
Lys Val Gln Ala Val Asn Thr Arg Ile Ser Asn Leu Thr Ala Ala Ala
            1060                1065                1070
Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr Glu Gly Pro Glu His
        1075                1080                1085
Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly Ser Lys Glu Glu Trp
    1090                1095                1100
Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe Phe Gly Leu Lys Gly
1105                1110                1115                1120
Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val Gly Ala Val Gly Asp
                1125                1130                1135
Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu Thr Gly Pro Ala Met
            1140                1145                1150
Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu
        1155                1160                1165
Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu Leu Ile Val Cys Phe
    1170                1175                1180
Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val Lys Glu Lys Glu Asp
1185                1190                1195                1200
Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys Glu Asp Asp Gly Thr
                1205                1210                1215
Phe Gly Glu Tyr Ser Asp Ala Glu Asp His Lys Pro Leu Lys Lys Gly
            1220                1225                1230
Ser Arg Thr Pro Ser Asp Arg Thr Val Lys Lys Glu Asp Ser Asp Asp
        1235                1240                1245
Ser Leu Val Asp Tyr Gly Glu Gly Val Asn Gly Gln Phe Asn Glu Asp
    1250                1255                1260
Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu Pro Ala
1265                1270                1275                1280
Glu Gly Asn Glu Ser Ser Glu Ala Pro Ser Pro Val Asn Ala Met Asn
                1285                1290                1295
Ser Phe Val


<210> 873
<211> 1236
<212> PRT
<213> Homo sapiens

<400> 873
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu
                245                 250                 255
Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr
            260                 265                 270
Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu
        275                 280                 285
Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp
    290                 295                 300
Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn
305                 310                 315                 320
Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly
                325                 330                 335
Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr
            340                 345                 350
Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln
        355                 360                 365
Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala
    370                 375                 380
Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro
385                 390                 395                 400
Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr
                405                 410                 415
Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys
            420                 425                 430
Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn
        435                 440                 445
Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr
    450                 455                 460
Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly
465                 470                 475                 480
Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala
                485                 490                 495
Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile
            500                 505                 510
Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg
        515                 520                 525
Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp
    530                 535                 540
Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly
545                 550                 555                 560
Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser
                565                 570                 575
Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu
            580                 585                 590
Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp
        595                 600                 605
Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser
    610                 615                 620
Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro
625                 630                 635                 640
Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr
                645                 650                 655
Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp
            660                 665                 670
Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met
        675                 680                 685
His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln
    690                 695                 700
Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg
705                 710                 715                 720
Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser
                725                 730                 735
Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala
            740                 745                 750
Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys
        755                 760                 765
Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val
    770                 775                 780
Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val
785                 790                 795                 800
Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro
                805                 810                 815
Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu
            820                 825                 830
Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala
        835                 840                 845
Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val
    850                 855                 860
His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly
865                 870                 875                 880
Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg
                885                 890                 895
Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His
            900                 905                 910
Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val
        915                 920                 925
Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val
    930                 935                 940
Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile
945                 950                 955                 960
Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser
                965                 970                 975
His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile
            980                 985                 990
Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala
        995                 1000                1005
Asn Lys Thr Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr
    1010                1015                1020
Lys Phe Tyr Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile
1025                1030                1035                1040
Thr Glu Glu Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro
                1045                1050                1055
Asp Val Gly Ala Gly Lys Val Gln Ala Val Asn Pro Arg Ile Ser Asn
            1060                1065                1070
Leu Thr Ala Ala Ala Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr
        1075                1080                1085
Glu Gly Pro Glu His Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly
    1090                1095                1100
Ser Lys Glu Glu Trp Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe
1105                1110                1115                1120
Phe Gly Leu Lys Gly Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val
                1125                1130                1135
Gly Ala Val Gly Asp Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu
            1140                1145                1150
Thr Gly Pro Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly
        1155                1160                1165
Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu
    1170                1175                1180
Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val
1185                1190                1195                1200
Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys
                1205                1210                1215
Glu Asp Asp Gly Thr Phe Gly Glu Tyr Arg Leu Phe Ser Phe Val Ser
            1220                1225                1230
Ser Ala Ser Phe
        1235

<210> 874
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 874
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240
Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu
                245                 250                 255
Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr
            260                 265                 270
Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu
        275                 280                 285
Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp
    290                 295                 300
Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn
305                 310                 315                 320
Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly
                325                 330                 335
Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr
            340                 345                 350
Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln
        355                 360                 365
Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala
    370                 375                 380
Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro
385                 390                 395                 400
Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr
                405                 410                 415
Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys
            420                 425                 430
Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn
        435                 440                 445
Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr
    450                 455                 460
Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly
465                 470                 475                 480
Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala
                485                 490                 495
Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile
            500                 505                 510
Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg
        515                 520                 525
Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp
    530                 535                 540
Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly
545                 550                 555                 560
Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser
                565                 570                 575
Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu
            580                 585                 590
Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp
        595                 600                 605
Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser
    610                 615                 620
Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro
625                 630                 635                 640
Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr
                645                 650                 655
Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp
            660                 665                 670
Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met
        675                 680                 685
His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln
    690                 695                 700
Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg
705                 710                 715                 720
Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser
                725                 730                 735
Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala
            740                 745                 750
Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys
        755                 760                 765
Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val
    770                 775                 780
Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val
785                 790                 795                 800
Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro
                805                 810                 815
Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu
            820                 825                 830
Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala
        835                 840                 845
Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val
    850                 855                 860
His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly
865                 870                 875                 880
Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg
                885                 890                 895
Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His
            900                 905                 910
Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val
        915                 920                 925
Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val
    930                 935                 940
Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile
945                 950                 955                 960
Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser
                965                 970                 975
His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile
            980                 985                 990
Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala
        995                 1000                1005
Asn Lys Thr Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr
    1010                1015                1020
Lys Phe Tyr Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile
1025                1030                1035                1040
Thr Glu Glu Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro
                1045                1050                1055
Asp Val Gly Ala Gly Lys Val Gln Ala Val Asn Pro Arg Ile Ser Asn
            1060                1065                1070
Leu Thr Ala Ala Ala Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr
        1075                1080                1085
Glu Gly Pro Glu His Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly
    1090                1095                1100
Ser Lys Glu Glu Trp Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe
1105                1110                1115                1120
Phe Gly Leu Lys Gly Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val
                1125                1130                1135
Gly Ala Val Gly Asp Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu
            1140                1145                1150
Thr Gly Pro Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly
        1155                1160                1165
Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu
    1170                1175                1180
Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val
1185                1190                1195                1200
Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys
                1205                1210                1215
Glu Asp Asp Gly Thr Phe Gly Glu Tyr Arg Ser Leu Glu Ser Asp Ala
            1220                1225                1230
Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg
        1235                1240                1245
Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu
    1250                1255                1260
Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr
1265                1270                1275                1280
Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu
                1285                1290                1295
Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val
            1300                1305

<210> 875
<211> 551
<212> PRT
<213> Homo sapiens

<400> 875
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Thr Ser Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Leu Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Trp Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Leu Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
305                 310                 315                 320
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                325                 330                 335
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            340                 345                 350
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        355                 360                 365
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    370                 375                 380
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
385                 390                 395                 400
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                405                 410                 415
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            420                 425                 430
Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser
        435                 440                 445
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    450                 455                 460
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro
465                 470                 475                 480
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                485                 490                 495
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            500                 505                 510
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        515                 520                 525
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    530                 535                 540
Gln Asp Pro Thr His Leu Val
545                 550

<210> 876
<211> 551
<212> PRT
<213> Homo sapiens

<400> 876
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
305                 310                 315                 320
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                325                 330                 335
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            340                 345                 350
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        355                 360                 365
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    370                 375                 380
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
385                 390                 395                 400
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                405                 410                 415
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            420                 425                 430
Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser
        435                 440                 445
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    450                 455                 460
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro
465                 470                 475                 480
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                485                 490                 495
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            500                 505                 510
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        515                 520                 525
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    530                 535                 540
Gln Asp Pro Thr His Leu Val
545                 550

<210> 877
<211> 309
<212> PRT
<213> Homo sapiens

<400> 877
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Arg Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Leu Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Trp Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Leu Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro
305

<210> 878
<211> 309
<212> PRT
<213> Homo sapiens

<400> 878
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Arg Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Leu Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Trp Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Leu Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro
305

<210> 879
<211> 551
<212> PRT
<213> Homo sapiens

<400> 879
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
305                 310                 315                 320
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                325                 330                 335
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            340                 345                 350
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        355                 360                 365
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    370                 375                 380
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
385                 390                 395                 400
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                405                 410                 415
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            420                 425                 430
Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser
        435                 440                 445
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    450                 455                 460
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro
465                 470                 475                 480
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                485                 490                 495
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            500                 505                 510
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        515                 520                 525
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    530                 535                 540
Gln Asp Pro Thr His Leu Val
545                 550

<210> 880
<211> 551
<212> PRT
<213> Homo sapiens

<400> 880
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Arg Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Leu Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Leu Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Trp Asn Met Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Leu Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
305                 310                 315                 320
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                325                 330                 335
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            340                 345                 350
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        355                 360                 365
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    370                 375                 380
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
385                 390                 395                 400
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                405                 410                 415
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            420                 425                 430
Ser Leu Leu Gly Gly Pro Arg Arg Pro Ser Thr Ala Pro Gly Gly Ser
        435                 440                 445
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    450                 455                 460
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro
465                 470                 475                 480
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                485                 490                 495
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            500                 505                 510
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        515                 520                 525
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    530                 535                 540
Gln Asp Pro Ile His Leu Val
545                 550

<210> 881
<211> 551
<212> PRT
<213> Homo sapiens

<400> 881
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Arg Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Leu Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Trp Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Met Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Glu Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Leu Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
305                 310                 315                 320
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                325                 330                 335
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            340                 345                 350
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        355                 360                 365
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    370                 375                 380
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
385                 390                 395                 400
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                405                 410                 415
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            420                 425                 430
Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser
        435                 440                 445
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    450                 455                 460
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Gly Gly Val Pro
465                 470                 475                 480
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                485                 490                 495
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            500                 505                 510
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        515                 520                 525
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    530                 535                 540
Gln Asp Pro Ile His Leu Val
545                 550

<210> 882
<211> 551
<212> PRT
<213> Homo sapiens

<400> 882
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
305                 310                 315                 320
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                325                 330                 335
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            340                 345                 350
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        355                 360                 365
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    370                 375                 380
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
385                 390                 395                 400
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                405                 410                 415
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            420                 425                 430
Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser
        435                 440                 445
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    450                 455                 460
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro
465                 470                 475                 480
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                485                 490                 495
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            500                 505                 510
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        515                 520                 525
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    530                 535                 540
Gln Asp Pro Thr His Leu Val
545                 550

<210> 883
<211> 551
<212> PRT
<213> Homo sapiens

<400> 883
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
305                 310                 315                 320
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                325                 330                 335
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            340                 345                 350
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        355                 360                 365
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    370                 375                 380
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
385                 390                 395                 400
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                405                 410                 415
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            420                 425                 430
Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser
        435                 440                 445
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    450                 455                 460
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro
465                 470                 475                 480
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                485                 490                 495
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            500                 505                 510
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        515                 520                 525
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    530                 535                 540
Gln Asp Pro Thr His Leu Val
545                 550

<210> 884
<211> 551
<212> PRT
<213> Homo sapiens

<400> 884
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30
Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp
        35                  40                  45
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140
Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270
Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
305                 310                 315                 320
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                325                 330                 335
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            340                 345                 350
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        355                 360                 365
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    370                 375                 380
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
385                 390                 395                 400
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                405                 410                 415
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            420                 425                 430
Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser
        435                 440                 445
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    450                 455                 460
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro
465                 470                 475                 480
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                485                 490                 495
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            500                 505                 510
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        515                 520                 525
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    530                 535                 540
Gln Asp Pro Thr His Leu Val
545                 550

<210> 885
<211> 321
<212> PRT
<213> Homo sapiens

<400> 885
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 886
<211> 321
<212> PRT
<213> Homo sapiens

<400> 886
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 887
<211> 321
<212> PRT
<213> Homo sapiens

<400> 887
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 888
<211> 321
<212> PRT
<213> Homo sapiens

<400> 888
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Thr Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 889
<211> 321
<212> PRT
<213> Homo sapiens

<400> 889
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Glu Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 890
<211> 321
<212> PRT
<213> Homo sapiens

<400> 890
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 891
<211> 321
<212> PRT
<213> Homo sapiens

<400> 891
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Ile Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 892
<211> 321
<212> PRT
<213> Homo sapiens

<400> 892
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Phe Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Arg Leu His
305                 310                 315                 320
Ser


<210> 893
<211> 321
<212> PRT
<213> Homo sapiens

<400> 893
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 894
<211> 226
<212> PRT
<213> Homo sapiens

<400> 894
Met Asn Ser Phe Ser Thr Thr Ala Phe Gly Pro Val Ala Phe Ser Leu
 1               5                  10                  15
Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro
            20                  25                  30
Gly Glu Asp Trp Gly Ser Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu
        35                  40                  45
Glu Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val
    50                  55                  60
Cys Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr
65                  70                  75                  80
Tyr Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys
                85                  90                  95
Asp Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln
            100                 105                 110
Asp Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu
        115                 120                 125
Arg Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His
    130                 135                 140
Val Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln
145                 150                 155                 160
Gly Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala
                165                 170                 175
Phe Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr
            180                 185                 190
Cys Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp
        195                 200                 205
Ser Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu
    210                 215                 220
His Ser
225

<210> 895
<211> 300
<212> PRT
<213> Homo sapiens

<400> 895
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Glu Leu Asn Glu Arg Asn Glu
            100                 105                 110
Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu Val Thr Lys Leu Arg
        115                 120                 125
Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys Asn Thr Cys Pro Glu
    130                 135                 140
Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr Phe Gly Lys Gly Thr
145                 150                 155                 160
Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp Asp Met Glu Gly Gln
                165                 170                 175
Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp Phe Leu Thr Lys His
            180                 185                 190
Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg Asn Leu Asp Leu Lys
        195                 200                 205
Gly Glu Phe Ile Trp Val Asp Gly Ser His Val Asp Tyr Ser Asn Trp
    210                 215                 220
Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly Glu Asp Cys Val Met
225                 230                 235                 240
Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe Cys Asp Arg Lys Leu
                245                 250                 255
Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys Thr Pro Pro Ala Ser
            260                 265                 270
Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser Arg Pro Asp Pro Asp
        275                 280                 285
Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His Ser
    290                 295                 300

<210> 896
<211> 321
<212> PRT
<213> Homo sapiens

<400> 896
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 897
<211> 226
<212> PRT
<213> Homo sapiens

<400> 897
Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu
 1               5                  10                  15
Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro
            20                  25                  30
Gly Glu Asp Trp Gly Ser Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu
        35                  40                  45
Glu Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val
    50                  55                  60
Cys Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr
65                  70                  75                  80
Tyr Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys
                85                  90                  95
Asp Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln
            100                 105                 110
Asp Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu
        115                 120                 125
Arg Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His
    130                 135                 140
Val Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln
145                 150                 155                 160
Gly Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala
                165                 170                 175
Phe Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr
            180                 185                 190
Cys Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp
        195                 200                 205
Ser Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu
    210                 215                 220
His Ser
225

<210> 898
<211> 172
<212> PRT
<213> Homo sapiens

<400> 898
Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys Asn Thr Cys Pro Glu
 1               5                  10                  15
Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr Phe Gly Lys Gly Thr
            20                  25                  30
Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp Asp Met Glu Gly Gln
        35                  40                  45
Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp Phe Leu Thr Lys His
    50                  55                  60
Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg Asn Leu Asp Leu Lys
65                  70                  75                  80
Gly Glu Phe Ile Trp Val Asp Gly Ser His Val Asp Tyr Ser Asn Trp
                85                  90                  95
Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly Glu Asp Cys Val Met
            100                 105                 110
Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe Cys Asp Arg Lys Leu
        115                 120                 125
Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys Thr Pro Pro Ala Ser
    130                 135                 140
Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser Arg Pro Asp Pro Asp
145                 150                 155                 160
Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His Ser
                165                 170

<210> 899
<211> 172
<212> PRT
<213> Homo sapiens

<400> 899
Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys Asn Thr Cys Pro Glu
 1               5                  10                  15
Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr Phe Gly Lys Gly Thr
            20                  25                  30
Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp Asp Met Glu Gly Gln
        35                  40                  45
Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp Phe Leu Thr Lys His
    50                  55                  60
Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg Asn Leu Asp Leu Lys
65                  70                  75                  80
Gly Glu Phe Ile Trp Val Asp Gly Ser His Val Asp Tyr Ser Asn Trp
                85                  90                  95
Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly Glu Asp Cys Val Met
            100                 105                 110
Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe Cys Asp Arg Lys Leu
        115                 120                 125
Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys Thr Pro Pro Ala Ser
    130                 135                 140
Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser Arg Pro Asp Pro Asp
145                 150                 155                 160
Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His Ser
                165                 170

<210> 900
<211> 172
<212> PRT
<213> Homo sapiens

<400> 900
Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys Asn Thr Cys Pro Glu
 1               5                  10                  15
Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr Phe Gly Lys Gly Thr
            20                  25                  30
Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp Asp Met Glu Gly Gln
        35                  40                  45
Leu Val Ser Ile His Ser Pro Gln Glu Gln Asp Phe Leu Thr Lys His
    50                  55                  60
Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg Asn Leu Asp Leu Lys
65                  70                  75                  80
Gly Glu Phe Ile Trp Val Asp Gly Ser His Val Asp Tyr Ser Asn Trp
                85                  90                  95
Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly Glu Asp Cys Val Met
            100                 105                 110
Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe Cys Asp Arg Lys Leu
        115                 120                 125
Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys Thr Pro Pro Ala Ser
    130                 135                 140
Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser Arg Pro Asp Pro Asp
145                 150                 155                 160
Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His Ser
                165                 170

<210> 901
<211> 321
<212> PRT
<213> Homo sapiens

<400> 901
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 902
<211> 320
<212> PRT
<213> Homo sapiens

<400> 902
Met Asn Pro Pro Ser Gln Glu Ile Glu Glu Leu Pro Arg Arg Arg Cys
 1               5                  10                  15
Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala Ala
            20                  25                  30
Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp Thr
        35                  40                  45
Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val Ser
    50                  55                  60
Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala Gln
65                  70                  75                  80
Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg Ala
                85                  90                  95
Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn Leu
            100                 105                 110
Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu Asn
        115                 120                 125
Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu Val
    130                 135                 140
Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys Asn
145                 150                 155                 160
Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr Phe
                165                 170                 175
Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp Asp
            180                 185                 190
Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp Phe
        195                 200                 205
Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg Asn
    210                 215                 220
Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val Asp
225                 230                 235                 240
Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly Glu
                245                 250                 255
Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe Cys
            260                 265                 270
Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys Thr
        275                 280                 285
Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser Arg
    290                 295                 300
Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His Ser
305                 310                 315                 320

<210> 903
<211> 321
<212> PRT
<213> Homo sapiens

<400> 903
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Thr Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 904
<211> 321
<212> PRT
<213> Homo sapiens

<400> 904
Met Glu Glu Gly Gln Tyr Ser Glu Ile Glu Glu Leu Pro Arg Arg Arg
 1               5                  10                  15
Cys Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala
            20                  25                  30
Ala Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp
        35                  40                  45
Thr Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val
    50                  55                  60
Ser Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala
65                  70                  75                  80
Gln Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg
                85                  90                  95
Ala Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn
            100                 105                 110
Leu Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu
        115                 120                 125
Asn Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu
    130                 135                 140
Val Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys
145                 150                 155                 160
Asn Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr
                165                 170                 175
Phe Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp
            180                 185                 190
Asp Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp
        195                 200                 205
Phe Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg
    210                 215                 220
Asn Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val
225                 230                 235                 240
Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly
                245                 250                 255
Glu Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe
            260                 265                 270
Cys Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys
        275                 280                 285
Thr Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser
    290                 295                 300
Arg Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His
305                 310                 315                 320
Ser


<210> 905
<211> 819
<212> PRT
<213> Homo sapiens

<400> 905
Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp
 1               5                  10                  15
Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro
            20                  25                  30
Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro
        35                  40                  45
Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys
    50                  55                  60
Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His
65                  70                  75                  80
Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr
                85                  90                  95
Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn
            100                 105                 110
His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile
        115                 120                 125
Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn
    130                 135                 140
Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His
145                 150                 155                 160
Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly
                165                 170                 175
Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu
            180                 185                 190
Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu
        195                 200                 205
Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg
    210                 215                 220
Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile
225                 230                 235                 240
Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg
                245                 250                 255
Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn
            260                 265                 270
Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg
        275                 280                 285
Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val
    290                 295                 300
Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr
305                 310                 315                 320
Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile
                325                 330                 335
Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn
            340                 345                 350
Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys
        355                 360                 365
Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser
    370                 375                 380
Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn
385                 390                 395                 400
Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser
                405                 410                 415
Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr
            420                 425                 430
Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys
        435                 440                 445
Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys
    450                 455                 460
Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys
465                 470                 475                 480
Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp
                485                 490                 495
Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys
            500                 505                 510
Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe
        515                 520                 525
Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn
    530                 535                 540
Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr
545                 550                 555                 560
Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu
                565                 570                 575
Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln
            580                 585                 590
Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly
        595                 600                 605
Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly
    610                 615                 620
Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu
625                 630                 635                 640
Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys
                645                 650                 655
Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn
            660                 665                 670
Cys Glu Thr Lys Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Thr Tyr
        675                 680                 685
Asn Glu Met Asn Thr Ala Leu Arg Asp Gly Leu Leu Val Phe Phe Phe
    690                 695                 700
Leu Ile Val Pro Leu Ile Val Cys Ala Ile Phe Ile Phe Ile Lys Arg
705                 710                 715                 720
Asp Gln Leu Trp Arg Ser Tyr Phe Arg Lys Lys Arg Ser Gln Thr Tyr
                725                 730                 735
Glu Ser Asp Gly Lys Asn Gln Ala Asn Pro Ser Arg Gln Pro Gly Ser
            740                 745                 750
Val Pro Arg His Val Ser Pro Val Thr Pro Pro Arg Glu Val Pro Ile
        755                 760                 765
Tyr Ala Asn Arg Phe Ala Val Pro Thr Tyr Ala Ala Lys Gln Pro Gln
    770                 775                 780
Gln Phe Pro Ser Arg Pro Pro Pro Pro Gln Pro Lys Val Ser Ser Gln
785                 790                 795                 800
Gly Asn Leu Ile Pro Ala Arg Pro Ala Pro Ala Pro Pro Leu Tyr Ser
                805                 810                 815
Ser Leu Thr


<210> 906
<211> 703
<212> PRT
<213> Homo sapiens

<400> 906
Gln Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile Ala Leu Ser Asp
 1               5                  10                  15
Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn Ala Ser Tyr Gly
            20                  25                  30
Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His Ile Ile Tyr Arg
        35                  40                  45
Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly Val Ser Asn Lys
    50                  55                  60
Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu Glu Pro Pro Ser
65                  70                  75                  80
Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu Pro Gln Thr Arg
                85                  90                  95
Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg Tyr Asp Met Met
            100                 105                 110
Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile Leu Leu Ala Asn
        115                 120                 125
Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg Ile Val Leu Val
    130                 135                 140
Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn Ile Val Gly Gly
145                 150                 155                 160
Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg Glu Lys Phe Leu
                165                 170                 175
Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val Leu Lys Lys Gly
            180                 185                 190
Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr Val Cys Ser Arg
        195                 200                 205
Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile Thr Val Glu Thr
    210                 215                 220
Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn Leu Gly Met Asn
225                 230                 235                 240
His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys Ser Cys Ile Met
                245                 250                 255
Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser Cys Ser Ala Glu
            260                 265                 270
Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn Cys Leu Leu Asn
        275                 280                 285
Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser Cys Gly Asn Lys
    290                 295                 300
Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr Pro Lys Glu Cys
305                 310                 315                 320
Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys Leu Lys Ser Phe
                325                 330                 335
Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys Arg Phe Leu Pro
            340                 345                 350
Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys Asp Val Pro Glu
        355                 360                 365
Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp Val Phe Ile Gln
    370                 375                 380
Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys Tyr Asn Gly Met
385                 390                 395                 400
Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe Gly Ser Lys Ala
                405                 410                 415
Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn Ser Lys Gly Asp
            420                 425                 430
Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr Lys Lys Cys Ala
        435                 440                 445
Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu Asn Val Gln Glu
    450                 455                 460
Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln Thr Pro Ser Arg
465                 470                 475                 480
Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly Ser Asp Val Pro
                485                 490                 495
Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly Ala Gly Lys Ile
            500                 505                 510
Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu Asn Tyr Asp Cys
        515                 520                 525
Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys Asn Ser Asn Lys
    530                 535                 540
Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn Cys Glu Thr Lys
545                 550                 555                 560
Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Thr Tyr Asn Glu Met Asn
                565                 570                 575
Thr Ala Leu Arg Asp Gly Leu Leu Val Phe Phe Phe Leu Ile Val Pro
            580                 585                 590
Leu Ile Val Cys Ala Ile Phe Ile Phe Ile Lys Arg Asp Gln Leu Trp
        595                 600                 605
Arg Ser Tyr Phe Arg Lys Lys Arg Ser Gln Thr Tyr Glu Ser Asp Gly
    610                 615                 620
Lys Asn Gln Ala Asn Pro Ser Arg Gln Pro Gly Ser Val Pro Arg His
625                 630                 635                 640
Val Ser Pro Val Thr Pro Pro Arg Glu Val Pro Ile Tyr Ala Asn Arg
                645                 650                 655
Phe Ala Val Pro Thr Tyr Ala Ala Lys Gln Pro Gln Gln Phe Pro Ser
            660                 665                 670
Arg Pro Pro Pro Pro Gln Pro Lys Val Ser Ser Gln Gly Asn Leu Ile
        675                 680                 685
Pro Ala Arg Pro Ala Pro Ala Pro Pro Leu Tyr Ser Ser Leu Thr
    690                 695                 700

<210> 907
<211> 631
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(631)
<223> Xaa = Any Amino Acid

<400> 907
Lys Asp Glu Glu Glu Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg
 1               5                  10                  15
Xaa Xaa Leu Ser Cys His Arg Pro Gly Met Trp Ser Val His Cys Arg
            20                  25                  30
Ser Lys Glu Xaa Xaa Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg
        35                  40                  45
Glu Glu Met Xaa Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Xaa Met
    50                  55                  60
Leu Asn Ile Arg Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly
65                  70                  75                  80
Asn Leu Ile Asn Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Xaa
                85                  90                  95
Val Gln Trp Arg Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser
            100                 105                 110
Ala Gln Leu Val Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala
        115                 120                 125
Phe Val Gly Thr Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val
    130                 135                 140
Phe Gly Gln Ile Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu
145                 150                 155                 160
Leu Gly His Asn Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser
                165                 170                 175
Cys Gly Ala Lys Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg
            180                 185                 190
Asn Phe Ser Ser Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn
        195                 200                 205
Lys Gly Gly Asn Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr
    210                 215                 220
Ser Ala Pro Ser Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys
225                 230                 235                 240
Asp Cys Gly Thr Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly
                245                 250                 255
Ser Thr Cys Lys Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys
            260                 265                 270
Cys Lys Asp Cys Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys
        275                 280                 285
Thr Ser Glu Cys Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe
    290                 295                 300
Cys Gln Pro Asp Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn
305                 310                 315                 320
Lys Ala Tyr Cys Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys
                325                 330                 335
Gln Val Ile Phe Xaa Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe
            340                 345                 350
Ile Glu Val Asn Xaa Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser
        355                 360                 365
Gly Asn Glu Tyr Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys
    370                 375                 380
Leu Gln Cys Glu Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro
385                 390                 395                 400
Ala Ile Ile Gln Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp
                405                 410                 415
Phe Gln Leu Gly Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly
            420                 425                 430
Thr Lys Cys Gly Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp
        435                 440                 445
Ala Ser Val Leu Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly
    450                 455                 460
His Gly Val Cys Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp
465                 470                 475                 480
Ala Pro Pro Asn Cys Glu Thr Lys Gly Tyr Gly Gly Ser Val Asp Ser
                485                 490                 495
Gly Pro Thr Tyr Asn Glu Met Asn Thr Ala Leu Arg Asp Gly Leu Leu
            500                 505                 510
Val Phe Phe Phe Leu Ile Val Pro Leu Ile Val Cys Ala Ile Phe Ile
        515                 520                 525
Phe Ile Lys Arg Asp Gln Leu Trp Arg Ser Tyr Phe Arg Lys Lys Arg
    530                 535                 540
Ser Gln Thr Tyr Glu Ser Asp Gly Lys Asn Gln Ala Asn Pro Ser Arg
545                 550                 555                 560
Gln Pro Gly Ser Val Pro Arg His Val Ser Pro Val Thr Pro Pro Arg
                565                 570                 575
Glu Val Pro Ile Tyr Ala Asn Arg Phe Ala Val Pro Thr Tyr Ala Ala
            580                 585                 590
Lys Gln Pro Gln Gln Phe Pro Ser Arg Pro Pro Pro Pro Gln Pro Lys
        595                 600                 605
Val Ser Ser Gln Gly Asn Leu Ile Pro Ala Arg Pro Ala Pro Ala Pro
    610                 615                 620
Pro Leu Tyr Ser Ser Leu Thr
625                 630

<210> 908
<211> 660
<212> PRT
<213> Homo sapiens

<400> 908
Met Trp Arg Glu Phe Ile Ile His Pro Leu Leu Leu Ala Thr Val Leu
 1               5                  10                  15
Asp Leu Arg Gly Leu Leu His Leu Glu Asn Ala Ser Tyr Gly Ile Glu
            20                  25                  30
Pro Leu Gln Met Ser Ser His Phe Glu His Ile Ile Tyr Arg Met Asp
        35                  40                  45
Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly Val Ser Asn Lys Asp Ile
    50                  55                  60
Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu Glu Pro Pro Ser Met Thr
65                  70                  75                  80
Gln Leu Leu Arg Arg Arg Arg Ala Val Leu Pro Gln Thr Arg Tyr Val
                85                  90                  95
Glu Leu Phe Ile Val Val Asp Lys Glu Arg Tyr Asp Met Met Gly Arg
            100                 105                 110
Asn Gln Thr Ala Val Arg Glu Glu Met Ile Leu Leu Ala Asn Tyr Leu
        115                 120                 125
Asp Ser Met Tyr Ile Met Leu Asn Ile Arg Ile Val Leu Val Gly Leu
    130                 135                 140
Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn Ile Val Gly Gly Ala Gly
145                 150                 155                 160
Asp Val Leu Gly Asn Phe Val Gln Trp Arg Glu Lys Phe Leu Ile Thr
                165                 170                 175
Arg Arg Arg His Asp Ser Ala Gln Leu Val Leu Lys Lys Gly Phe Gly
            180                 185                 190
Gly Thr Ala Gly Met Ala Phe Val Gly Thr Val Cys Ser Arg Ser His
        195                 200                 205
Ala Gly Gly Ile Asn Val Phe Gly Gln Ile Thr Val Glu Thr Phe Ala
    210                 215                 220
Ser Ile Val Ala His Glu Leu Gly His Asn Leu Gly Met Asn His Asp
225                 230                 235                 240
Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys Ser Cys Ile Met Asn Ser
                245                 250                 255
Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser Cys Ser Ala Glu Asp Phe
            260                 265                 270
Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn Cys Leu Leu Asn Ile Pro
        275                 280                 285
Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser Cys Gly Asn Lys Leu Val
    290                 295                 300
Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr Pro Lys Glu Cys Glu Leu
305                 310                 315                 320
Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys Leu Lys Ser Phe Ala Glu
                325                 330                 335
Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys Arg Phe Leu Pro Gly Gly
            340                 345                 350
Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys Asp Val Pro Glu Tyr Cys
        355                 360                 365
Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp Val Phe Ile Gln Asn Gly
    370                 375                 380
Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys Tyr Asn Gly Met Cys Gln
385                 390                 395                 400
Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe Gly Ser Lys Ala Lys Ala
                405                 410                 415
Ala Pro Lys Asp Cys Phe Ile Glu Val Asn Ser Lys Gly Asp Arg Phe
            420                 425                 430
Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr Lys Lys Cys Ala Thr Gly
        435                 440                 445
Leu Ser Leu Lys Phe His Ala Pro Phe Leu Ser Thr Met Leu Gln Glu
    450                 455                 460
Ala Val Arg Gln Thr Gly Thr Tyr Leu Gly Gly Ser Val Cys Cys Met
465                 470                 475                 480
Lys Ser Asp Cys Arg Ile Val Thr Leu Val Lys Asn Ala Leu Cys Gly
                485                 490                 495
Lys Leu Gln Cys Glu Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val
            500                 505                 510
Pro Ala Ile Ile Gln Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val
        515                 520                 525
Asp Phe Gln Leu Gly Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu
    530                 535                 540
Gly Thr Lys Cys Gly Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val
545                 550                 555                 560
Asp Ala Ser Val Leu Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His
                565                 570                 575
Gly His Gly Val Cys Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly
            580                 585                 590
Trp Ala Pro Pro Asn Cys Glu Thr Lys Gly Tyr Gly Gly Ser Val Asp
        595                 600                 605
Ser Gly Pro Thr Tyr Asn Glu Met Asn Thr Ala Leu Arg Asp Gly Leu
    610                 615                 620
Leu Val Phe Phe Phe Leu Ile Val Pro Leu Ile Val Cys Asp Tyr Phe
625                 630                 635                 640
Tyr Leu His Gln Glu Gly Ser Thr Val Glu Lys Leu Leu Gln Lys Glu
                645                 650                 655
Glu Ile Thr Asn
            660

<210> 909
<211> 819
<212> PRT
<213> Homo sapiens

<400> 909
Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp
 1               5                  10                  15
Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro
            20                  25                  30
Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro
        35                  40                  45
Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys
    50                  55                  60
Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His
65                  70                  75                  80
Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr
                85                  90                  95
Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn
            100                 105                 110
His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile
        115                 120                 125
Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn
    130                 135                 140
Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His
145                 150                 155                 160
Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly
                165                 170                 175
Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu
            180                 185                 190
Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu
        195                 200                 205
Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg
    210                 215                 220
Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile
225                 230                 235                 240
Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg
                245                 250                 255
Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn
            260                 265                 270
Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg
        275                 280                 285
Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val
    290                 295                 300
Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr
305                 310                 315                 320
Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile
                325                 330                 335
Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn
            340                 345                 350
Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys
        355                 360                 365
Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser
    370                 375                 380
Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn
385                 390                 395                 400
Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser
                405                 410                 415
Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr
            420                 425                 430
Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys
        435                 440                 445
Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys
    450                 455                 460
Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys
465                 470                 475                 480
Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp
                485                 490                 495
Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys
            500                 505                 510
Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe
        515                 520                 525
Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn
    530                 535                 540
Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr
545                 550                 555                 560
Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu
                565                 570                 575
Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln
            580                 585                 590
Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly
        595                 600                 605
Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly
    610                 615                 620
Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu
625                 630                 635                 640
Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys
                645                 650                 655
Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn
            660                 665                 670
Cys Glu Thr Lys Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Thr Tyr
        675                 680                 685
Asn Glu Met Asn Thr Ala Leu Arg Asp Gly Leu Leu Val Phe Phe Phe
    690                 695                 700
Leu Ile Val Pro Leu Ile Val Cys Ala Ile Phe Ile Phe Ile Lys Arg
705                 710                 715                 720
Asp Gln Leu Trp Arg Ser Tyr Phe Arg Lys Lys Arg Ser Gln Thr Tyr
                725                 730                 735
Glu Ser Asp Gly Lys Asn Gln Ala Asn Pro Ser Arg Gln Pro Gly Ser
            740                 745                 750
Val Pro Arg His Val Ser Pro Val Thr Pro Pro Arg Glu Val Pro Ile
        755                 760                 765
Tyr Ala Asn Arg Phe Ala Val Pro Thr Tyr Ala Ala Lys Gln Pro Gln
    770                 775                 780
Gln Phe Pro Ser Arg Pro Pro Pro Pro Gln Pro Lys Val Ser Ser Gln
785                 790                 795                 800
Gly Asn Leu Ile Pro Ala Arg Pro Ala Pro Ala Pro Pro Leu Tyr Ser
                805                 810                 815
Ser Leu Thr


<210> 910
<211> 819
<212> PRT
<213> Homo sapiens

<400> 910
Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp
 1               5                  10                  15
Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro
            20                  25                  30
Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro
        35                  40                  45
Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys
    50                  55                  60
Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His
65                  70                  75                  80
Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr
                85                  90                  95
Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn
            100                 105                 110
His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile
        115                 120                 125
Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn
    130                 135                 140
Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His
145                 150                 155                 160
Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly
                165                 170                 175
Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu
            180                 185                 190
Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu
        195                 200                 205
Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg
    210                 215                 220
Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile
225                 230                 235                 240
Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg
                245                 250                 255
Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn
            260                 265                 270
Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg
        275                 280                 285
Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val
    290                 295                 300
Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr
305                 310                 315                 320
Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile
                325                 330                 335
Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn
            340                 345                 350
Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys
        355                 360                 365
Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser
    370                 375                 380
Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn
385                 390                 395                 400
Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser
                405                 410                 415
Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr
            420                 425                 430
Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys
        435                 440                 445
Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys
    450                 455                 460
Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys
465                 470                 475                 480
Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp
                485                 490                 495
Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys
            500                 505                 510
Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe
        515                 520                 525
Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn
    530                 535                 540
Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr
545                 550                 555                 560
Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu
                565                 570                 575
Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln
            580                 585                 590
Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly
        595                 600                 605
Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly
    610                 615                 620
Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu
625                 630                 635                 640
Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys
                645                 650                 655
Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn
            660                 665                 670
Cys Glu Thr Lys Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Thr Tyr
        675                 680                 685
Asn Glu Met Asn Thr Ala Leu Arg Asp Gly Leu Leu Val Phe Phe Phe
    690                 695                 700
Leu Ile Val Pro Leu Ile Val Cys Ala Ile Phe Ile Phe Ile Lys Arg
705                 710                 715                 720
Asp Gln Leu Trp Arg Ser Tyr Phe Arg Lys Lys Arg Ser Gln Thr Tyr
                725                 730                 735
Glu Ser Asp Gly Lys Asn Gln Ala Asn Pro Ser Arg Gln Pro Gly Ser
            740                 745                 750
Val Pro Arg His Val Ser Pro Val Thr Pro Pro Arg Glu Val Pro Ile
        755                 760                 765
Tyr Ala Asn Arg Phe Ala Val Pro Thr Tyr Ala Ala Lys Gln Pro Gln
    770                 775                 780
Gln Phe Pro Ser Arg Pro Pro Pro Pro Gln Pro Lys Val Ser Ser Gln
785                 790                 795                 800
Gly Asn Leu Ile Pro Ala Arg Pro Ala Pro Ala Pro Pro Leu Tyr Ser
                805                 810                 815
Ser Leu Thr


<210> 911
<211> 642
<212> PRT
<213> Homo sapiens

<400> 911
Met Ser Asn Arg Ser Ser Phe Ser Arg Leu Thr Trp Phe Arg Lys Gln
 1               5                  10                  15
Arg Lys Ala Val Val Ser Thr Ser Asp Lys Lys Met Pro Asn Gly Ile
            20                  25                  30
Leu Glu Glu Gln Glu Gln Gln Arg Val Met Leu Leu Ser Arg Ser Pro
        35                  40                  45
Ser Gly Pro Lys Lys Tyr Phe Pro Ile Pro Val Glu His Leu Glu Glu
    50                  55                  60
Glu Ile Arg Ile Arg Ser Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu
65                  70                  75                  80
Phe Asn Ser Leu Pro Ser Gly His Ile Gln Gly Thr Phe Glu Leu Ala
                85                  90                  95
Asn Lys Glu Glu Asn Arg Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro
            100                 105                 110
Asn Asp His Ser Arg Val Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys
        115                 120                 125
Ser Asp Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn
    130                 135                 140
Lys Phe Ile Ala Ala Gln Gly Pro Lys Gln Glu Thr Val Asn Asp Phe
145                 150                 155                 160
Trp Arg Met Val Trp Glu Gln Lys Ser Ala Thr Ile Val Met Leu Thr
                165                 170                 175
Asn Leu Lys Glu Arg Lys Glu Glu Lys Cys His Gln Tyr Trp Pro Asp
            180                 185                 190
Gln Gly Cys Trp Thr Tyr Gly Asn Ile Arg Val Cys Val Glu Asp Cys
        195                 200                 205
Val Val Leu Val Asp Tyr Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln
    210                 215                 220
Leu Pro Asp Gly Cys Lys Ala Pro Arg Leu Val Ser Gln Leu His Phe
225                 230                 235                 240
Thr Ser Trp Pro Asp Phe Gly Val Pro Phe Thr Pro Ile Gly Met Leu
                245                 250                 255
Lys Phe Leu Lys Lys Val Lys Thr Leu Asn Pro Val His Ala Gly Pro
            260                 265                 270
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile
        275                 280                 285
Val Ile Asp Ala Met Met Ala Met Met His Ala Glu Gln Lys Val Asp
    290                 295                 300
Val Phe Glu Phe Val Ser Arg Ile Arg Asn Gln Arg Pro Gln Met Val
305                 310                 315                 320
Gln Thr Asp Met Gln Tyr Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr
                325                 330                 335
Tyr Leu Tyr Gly Asp Thr Glu Leu Asp Val Ser Ser Leu Glu Lys His
            340                 345                 350
Leu Gln Thr Met His Gly Thr Thr Thr His Phe Asp Lys Ile Gly Leu
        355                 360                 365
Glu Glu Glu Phe Arg Lys Leu Thr Asn Val Arg Ile Met Lys Glu Asn
    370                 375                 380
Met Arg Thr Gly Asn Leu Pro Ala Asn Met Lys Lys Ala Arg Val Ile
385                 390                 395                 400
Gln Ile Ile Pro Tyr Asp Phe Asn Arg Val Ile Leu Ser Met Lys Arg
                405                 410                 415
Gly Gln Glu Tyr Thr Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr
            420                 425                 430
Arg Gln Lys Asp Tyr Phe Ile Ala Thr Gln Gly Pro Leu Ala His Thr
        435                 440                 445
Val Glu Asp Phe Trp Arg Met Ile Trp Asp Trp Lys Ser His Thr Ile
    450                 455                 460
Val Met Leu Thr Glu Val Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln
465                 470                 475                 480
Tyr Trp Pro Thr Glu Gly Ser Val Thr His Gly Glu Ile Thr Ile Glu
                485                 490                 495
Ile Lys Asn Asp Thr Leu Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu
            500                 505                 510
Val Thr Leu Asn Gln Pro Gln Ala Arg Gln Glu Glu Gln Val Arg Val
        515                 520                 525
Val Arg Gln Phe His Phe His Gly Trp Pro Glu Ile Gly Ile Pro Ala
    530                 535                 540
Glu Gly Lys Gly Met Ile Asp Leu Ile Ala Ala Val Gln Lys Gln Gln
545                 550                 555                 560
Gln Gln Thr Gly Asn His Pro Ile Thr Val His Cys Ser Ala Gly Ala
                565                 570                 575
Gly Arg Thr Gly Thr Phe Ile Ala Leu Ser Asn Ile Leu Glu Arg Val
            580                 585                 590
Lys Ala Glu Gly Leu Leu Asp Val Phe Gln Ala Val Lys Ser Leu Arg
        595                 600                 605
Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys
    610                 615                 620
Tyr Lys Val Val Gln Asp Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn
625                 630                 635                 640
Phe Lys


<210> 912
<211> 700
<212> PRT
<213> Homo sapiens

<400> 912
Met Glu Pro Leu Cys Pro Leu Leu Leu Val Gly Phe Ser Leu Pro Leu
 1               5                  10                  15
Ala Arg Ala Leu Arg Gly Asn Glu Thr Thr Ala Asp Ser Asn Glu Thr
            20                  25                  30
Thr Thr Thr Ser Gly Pro Pro Asp Pro Gly Ala Ser Gln Pro Leu Leu
        35                  40                  45
Ala Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Val Leu Leu Leu
    50                  55                  60
Ala Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val Ser
65                  70                  75                  80
Thr Ser Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu Gln
                85                  90                  95
Gln Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys Tyr
            100                 105                 110
Phe Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Ile Arg Ser
        115                 120                 125
Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu Phe Asn Ser Leu Pro Ser
    130                 135                 140
Gly His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn Arg
145                 150                 155                 160
Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Ser Arg Val
                165                 170                 175
Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn Ala
            180                 185                 190
Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala Gln
        195                 200                 205
Gly Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp Glu
    210                 215                 220
Gln Lys Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg Lys
225                 230                 235                 240
Glu Glu Lys Cys His Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr
                245                 250                 255
Gly Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp Tyr
            260                 265                 270
Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln Leu Pro Asp Gly Cys Lys
        275                 280                 285
Ala Pro Arg Leu Val Ser Gln Leu His Phe Thr Ser Trp Pro Asp Phe
    290                 295                 300
Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val
305                 310                 315                 320
Lys Thr Leu Asn Pro Val His Ala Gly Pro Ile Val Val His Cys Ser
                325                 330                 335
Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ala Met Met
            340                 345                 350
Ala Met Met His Ala Glu Gln Lys Val Asp Val Phe Glu Phe Val Ser
        355                 360                 365
Arg Ile Arg Asn Gln Arg Pro Gln Met Val Gln Thr Asp Met Gln Tyr
    370                 375                 380
Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr Tyr Leu Tyr Gly Asp Thr
385                 390                 395                 400
Glu Leu Asp Val Ser Ser Leu Glu Lys His Leu Gln Thr Met His Gly
                405                 410                 415
Thr Thr Thr His Phe Asp Lys Ile Gly Leu Glu Glu Glu Phe Arg Lys
            420                 425                 430
Leu Thr Asn Val Arg Ile Met Lys Glu Asn Met Arg Thr Gly Asn Leu
        435                 440                 445
Pro Ala Asn Met Lys Lys Ala Arg Val Ile Gln Ile Ile Pro Tyr Asp
    450                 455                 460
Phe Asn Arg Val Ile Leu Ser Met Lys Arg Gly Gln Glu Tyr Thr Asp
465                 470                 475                 480
Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp Tyr Phe
                485                 490                 495
Ile Ala Thr Gln Gly Pro Leu Ala His Thr Val Glu Asp Phe Trp Arg
            500                 505                 510
Met Ile Trp Glu Trp Lys Ser His Thr Ile Val Met Leu Thr Glu Val
        515                 520                 525
Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln Tyr Trp Pro Thr Glu Gly
    530                 535                 540
Ser Val Thr His Gly Glu Ile Thr Ile Glu Ile Lys Asn Asp Thr Leu
545                 550                 555                 560
Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu Val Thr Leu Asn Gln Pro
                565                 570                 575
Gln Ala Arg Gln Glu Glu Gln Val Arg Val Val Arg Gln Phe His Phe
            580                 585                 590
His Gly Trp Pro Glu Ile Gly Ile Pro Ala Glu Gly Lys Gly Met Ile
        595                 600                 605
Asp Leu Ile Ala Ala Val Gln Lys Gln Gln Gln Gln Thr Gly Asn His
    610                 615                 620
Pro Ile Thr Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe
625                 630                 635                 640
Ile Ala Leu Ser Asn Ile Leu Glu Arg Val Lys Ala Glu Gly Leu Leu
                645                 650                 655
Asp Val Phe Gln Ala Val Lys Ser Leu Arg Leu Gln Arg Pro His Met
            660                 665                 670
Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Asp
        675                 680                 685
Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn Phe Lys
    690                 695                 700

<210> 913
<211> 249
<212> PRT
<213> Homo sapiens

<400> 913
Lys Glu Asn Met Arg Thr Gly Asn Leu Pro Ala Asn Met Lys Lys Ala
 1               5                  10                  15
Arg Val Ile Gln Ile Ile Pro Tyr Asp Phe Asn Arg Val Ile Leu Ser
            20                  25                  30
Met Lys Arg Gly Gln Glu Tyr Thr Asp Tyr Ile Asn Ala Ser Phe Ile
        35                  40                  45
Asp Gly Tyr Arg Gln Lys Asp Tyr Phe Ile Ala Thr Gly Gly Pro Leu
    50                  55                  60
Ala His Thr Val Glu Asp Phe Trp Arg Met Ile Trp Glu Trp Lys Ser
65                  70                  75                  80
His Thr Ile Val Met Leu Thr Glu Val Gln Glu Arg Glu Gln Asp Lys
                85                  90                  95
Cys Tyr Gln Tyr Trp Pro Thr Glu Gly Ser Val Thr His Gly Glu Ile
            100                 105                 110
Thr Ile Glu Ile Lys Asn Asp Thr Leu Ser Glu Ala Ile Ser Ile Phe
        115                 120                 125
Leu Val Thr Leu Asn Gln Pro Gln Ala Arg Gln Glu Glu Gln Val Arg
    130                 135                 140
Val Val Arg Gln Phe His Phe His Gly Trp Pro Glu Ile Gly Ile Pro
145                 150                 155                 160
Ala Glu Gly Lys Gly Met Ile Asp Leu Ile Ala Ala Val Gln Lys Gln
                165                 170                 175
Gln Gln Gln Thr Gly Asn His Pro Ile Thr Val His Cys Ser Ala Gly
            180                 185                 190
Ala Gly Arg Thr Gly Thr Phe Ile Ala Leu Ser Asn Ile Leu Glu Arg
        195                 200                 205
Val Lys Ala Glu Gly Leu Leu Asp Val Phe Gln Ala Val Lys Ser Leu
    210                 215                 220
Arg Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu Phe
225                 230                 235                 240
Cys Tyr Lys Val Val Gln Asp Phe Ile
                245

<210> 914
<211> 298
<212> PRT
<213> Homo sapiens

<400> 914
Lys Glu Asn Met Arg Thr Gly Asn Leu Pro Ala Asn Met Lys Lys Ala
 1               5                  10                  15
Arg Val Ile Gln Ile Ile Pro Tyr Asp Phe Asn Arg Val Ile Leu Ser
            20                  25                  30
Met Lys Arg Gly Gln Glu Tyr Thr Asp Tyr Ile Asn Ala Ser Phe Ile
        35                  40                  45
Asp Gly Tyr Arg Gln Lys Asp Tyr Phe Ile Ala Thr Gln Gly Pro Leu
    50                  55                  60
Ala His Thr Val Glu Asp Phe Trp Arg Met Ile Trp Glu Trp Lys Ser
65                  70                  75                  80
His Thr Ile Val Met Leu Thr Glu Val Gln Glu Arg Glu Gln Asp Lys
                85                  90                  95
Cys Tyr Gln Tyr Trp Pro Thr Glu Gly Ser Val Thr His Gly Glu Ile
            100                 105                 110
Thr Ile Glu Ile Lys Asn Asp Thr Leu Ser Glu Ala Ile Ser Ile Phe
        115                 120                 125
Leu Val Thr Leu Asn Gln Pro Gln Ala Arg Gln Glu Glu Gln Val Arg
    130                 135                 140
Val Val Arg Gln Phe His Phe His Gly Trp Pro Glu Ile Gly Ile Pro
145                 150                 155                 160
Ala Glu Gly Lys Gly Met Ile Asp Leu Ile Ala Ala Val Gln Lys Gln
                165                 170                 175
Gln Gln Gln Thr Gly Asn His Pro Ile Thr Val His Cys Ser Ala Gly
            180                 185                 190
Ala Gly Arg Thr Gly Thr Phe Ile Ala Leu Ser Asn Ile Leu Glu Arg
        195                 200                 205
Val Lys Ala Glu Gly Leu Leu Asp Val Phe Gln Ala Val Lys Ser Leu
    210                 215                 220
Arg Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu Phe
225                 230                 235                 240
Cys Tyr Lys Val Val Gln Asp Phe Ile Ala Leu Ser Asn Ile Leu Glu
                245                 250                 255
Arg Val Lys Ala Glu Gly Leu Leu Asp Val Phe Gln Ala Val Lys Ser
            260                 265                 270
Leu Arg Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu
        275                 280                 285
Phe Cys Tyr Lys Val Val Gln Asp Phe Ile
    290                 295

<210> 915
<211> 700
<212> PRT
<213> Homo sapiens

<400> 915
Met Glu Pro Leu Cys Pro Leu Leu Leu Val Gly Phe Ser Leu Pro Leu
 1               5                  10                  15
Ala Arg Ala Leu Arg Gly Asn Glu Thr Thr Ala Asp Ser Asn Glu Thr
            20                  25                  30
Thr Thr Thr Ser Gly Pro Pro Asp Pro Gly Ala Ser Gln Pro Leu Leu
        35                  40                  45
Ala Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Val Leu Leu Leu
    50                  55                  60
Ala Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val Ser
65                  70                  75                  80
Thr Ser Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu Gln
                85                  90                  95
Gln Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys Tyr
            100                 105                 110
Phe Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Ile Arg Ser
        115                 120                 125
Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu Phe Asn Ser Leu Pro Ser
    130                 135                 140
Gly His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn Arg
145                 150                 155                 160
Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Ser Arg Val
                165                 170                 175
Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn Ala
            180                 185                 190
Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala Gln
        195                 200                 205
Gly Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp Glu
    210                 215                 220
Gln Lys Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg Lys
225                 230                 235                 240
Glu Glu Lys Cys His Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr
                245                 250                 255
Gly Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp Tyr
            260                 265                 270
Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln Leu Pro Asp Gly Cys Lys
        275                 280                 285
Ala Pro Arg Leu Val Ser Gln Leu His Phe Thr Ser Trp Pro Asp Phe
    290                 295                 300
Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val
305                 310                 315                 320
Lys Thr Leu Asn Pro Val His Ala Gly Pro Ile Val Val His Cys Ser
                325                 330                 335
Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ala Met Met
            340                 345                 350
Ala Met Met His Ala Glu Gln Lys Val Asp Val Phe Glu Phe Val Ser
        355                 360                 365
Arg Ile Arg Asn Gln Arg Pro Gln Met Val Gln Thr Asp Met Gln Tyr
    370                 375                 380
Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr Tyr Leu Tyr Gly Asp Thr
385                 390                 395                 400
Glu Leu Asp Val Ser Ser Leu Glu Lys His Leu Gln Thr Met His Gly
                405                 410                 415
Thr Thr Thr His Phe Asp Lys Ile Gly Leu Glu Glu Glu Phe Arg Lys
            420                 425                 430
Leu Thr Asn Val Arg Ile Met Lys Glu Asn Met Arg Thr Gly Asn Leu
        435                 440                 445
Pro Ala Asn Met Lys Lys Ala Arg Val Ile Gln Ile Ile Pro Tyr Asp
    450                 455                 460
Phe Asn Arg Val Ile Leu Ser Met Lys Arg Gly Gln Glu Tyr Thr Asp
465                 470                 475                 480
Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp Tyr Phe
                485                 490                 495
Ile Ala Thr Gln Gly Pro Leu Ala His Thr Val Glu Asp Phe Trp Arg
            500                 505                 510
Met Ile Trp Glu Trp Lys Ser His Thr Ile Val Met Leu Thr Glu Val
        515                 520                 525
Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln Tyr Trp Pro Thr Glu Gly
    530                 535                 540
Ser Val Thr His Gly Glu Ile Thr Ile Glu Ile Lys Asn Asp Thr Leu
545                 550                 555                 560
Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu Val Thr Leu Asn Gln Pro
                565                 570                 575
Gln Ala Arg Gln Glu Glu Gln Val Arg Val Val Arg Gln Phe His Phe
            580                 585                 590
His Gly Trp Pro Glu Ile Gly Ile Pro Ala Glu Gly Lys Gly Met Ile
        595                 600                 605
Asp Leu Ile Ala Ala Val Gln Lys Gln Gln Gln Gln Thr Gly Asn His
    610                 615                 620
Pro Ile Thr Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe
625                 630                 635                 640
Ile Ala Leu Ser Asn Ile Leu Glu Arg Val Lys Ala Glu Gly Leu Leu
                645                 650                 655
Asp Val Phe Gln Ala Val Lys Ser Leu Arg Leu Gln Arg Pro His Met
            660                 665                 670
Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Asp
        675                 680                 685
Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn Phe Lys
    690                 695                 700

<210> 916
<211> 700
<212> PRT
<213> Homo sapiens

<400> 916
Met Glu Pro Leu Cys Pro Leu Leu Leu Val Gly Phe Ser Leu Pro Leu
 1               5                  10                  15
Ala Arg Ala Leu Arg Gly Asn Glu Thr Thr Ala Asp Ser Asn Glu Thr
            20                  25                  30
Thr Thr Thr Ser Gly Pro Pro Asp Pro Gly Ala Ser Gln Pro Leu Leu
        35                  40                  45
Ala Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Val Leu Leu Leu
    50                  55                  60
Ala Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val Ser
65                  70                  75                  80
Thr Ser Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu Gln
                85                  90                  95
Gln Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys Tyr
            100                 105                 110
Phe Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Ile Arg Ser
        115                 120                 125
Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu Phe Asn Ser Leu Pro Ser
    130                 135                 140
Gly His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn Arg
145                 150                 155                 160
Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Ser Arg Val
                165                 170                 175
Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn Ala
            180                 185                 190
Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala Gln
        195                 200                 205
Gly Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp Glu
    210                 215                 220
Gln Lys Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg Lys
225                 230                 235                 240
Glu Glu Lys Cys His Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr
                245                 250                 255
Gly Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp Tyr
            260                 265                 270
Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln Leu Pro Asp Gly Cys Lys
        275                 280                 285
Ala Pro Arg Leu Val Ser Gln Leu His Phe Thr Ser Trp Pro Asp Phe
    290                 295                 300
Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val
305                 310                 315                 320
Lys Thr Leu Asn Pro Val His Ala Gly Pro Ile Val Val His Cys Ser
                325                 330                 335
Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ala Met Met
            340                 345                 350
Ala Met Met His Ala Glu Gln Lys Val Asp Val Phe Glu Phe Val Ser
        355                 360                 365
Arg Ile Arg Asn Gln Arg Pro Gln Met Val Gln Thr Asp Met Gln Tyr
    370                 375                 380
Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr Tyr Leu Tyr Gly Asp Thr
385                 390                 395                 400
Glu Leu Asp Val Ser Ser Leu Glu Lys His Leu Gln Thr Met His Gly
                405                 410                 415
Thr Thr Thr His Phe Asp Lys Ile Gly Leu Glu Glu Glu Phe Arg Lys
            420                 425                 430
Leu Thr Asn Val Arg Ile Met Lys Glu Asn Met Arg Thr Gly Asn Leu
        435                 440                 445
Pro Ala Asn Met Lys Lys Ala Arg Val Ile Gln Ile Ile Pro Tyr Asp
    450                 455                 460
Phe Asn Arg Val Ile Leu Ser Met Lys Arg Gly Gln Glu Tyr Thr Asp
465                 470                 475                 480
Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp Tyr Phe
                485                 490                 495
Ile Ala Thr Gln Gly Pro Leu Ala His Thr Val Glu Asp Phe Trp Arg
            500                 505                 510
Met Ile Trp Glu Trp Lys Ser His Thr Ile Val Met Leu Thr Glu Val
        515                 520                 525
Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln Tyr Trp Pro Thr Glu Gly
    530                 535                 540
Ser Val Thr His Gly Glu Ile Thr Ile Glu Ile Lys Asn Asp Thr Leu
545                 550                 555                 560
Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu Val Thr Leu Asn Gln Pro
                565                 570                 575
Gln Ala Arg Gln Glu Glu Gln Val Arg Val Val Arg Gln Phe His Phe
            580                 585                 590
His Gly Trp Pro Glu Ile Gly Ile Pro Ala Glu Gly Lys Gly Met Ile
        595                 600                 605
Asp Leu Ile Ala Ala Val Gln Lys Gln Gln Gln Gln Thr Gly Asn His
    610                 615                 620
Pro Ile Thr Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe
625                 630                 635                 640
Ile Ala Leu Ser Asn Ile Leu Glu Arg Val Lys Ala Glu Gly Leu Leu
                645                 650                 655
Asp Val Phe Gln Ala Val Lys Ser Leu Arg Leu Gln Arg Pro His Met
            660                 665                 670
Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Asp
        675                 680                 685
Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn Phe Lys
    690                 695                 700

<210> 917
<211> 717
<212> PRT
<213> Homo sapiens

<400> 917
Asp Gln Thr Gly Pro Pro Glu Thr Ile Ala Phe Thr Phe Pro Arg Ser
 1               5                  10                  15
Thr Met Glu Pro Leu Cys Pro Leu Leu Leu Val Gly Phe Ser Leu Pro
            20                  25                  30
Leu Ala Arg Ala Leu Arg Gly Asn Glu Thr Thr Ala Asp Ser Asn Glu
        35                  40                  45
Thr Thr Thr Thr Ser Gly Pro Pro Asp Pro Gly Ala Ser Gln Pro Leu
    50                  55                  60
Leu Ala Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Val Leu Leu
65                  70                  75                  80
Leu Ala Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val
                85                  90                  95
Ser Thr Ser Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu
            100                 105                 110
Gln Gln Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys
        115                 120                 125
Tyr Phe Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Ile Arg
    130                 135                 140
Ser Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu Phe Asn Ser Leu Pro
145                 150                 155                 160
Ser Gly His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn
                165                 170                 175
Arg Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Ser Arg
            180                 185                 190
Val Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn
        195                 200                 205
Ala Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala
    210                 215                 220
Gln Gly Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp
225                 230                 235                 240
Glu Gln Lys Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg
                245                 250                 255
Lys Glu Glu Lys Cys His Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr
            260                 265                 270
Tyr Gly Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp
        275                 280                 285
Tyr Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln Leu Pro Asp Gly Cys
    290                 295                 300
Lys Ala Pro Arg Leu Val Ser Gln Leu His Phe Thr Ser Trp Pro Asp
305                 310                 315                 320
Phe Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys Lys
                325                 330                 335
Val Lys Thr Leu Asn Pro Val His Ala Gly Pro Ile Val Val His Cys
            340                 345                 350
Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ala Met
        355                 360                 365
Met Ala Met Met His Ala Glu Gln Lys Val Asp Val Phe Glu Phe Val
    370                 375                 380
Ser Arg Ile Arg Asn Gln Arg Pro Gln Met Val Gln Thr Asp Met Gln
385                 390                 395                 400
Tyr Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr Tyr Leu Tyr Gly Asp
                405                 410                 415
Thr Glu Leu Asp Val Ser Ser Leu Glu Lys His Leu Gln Thr Met His
            420                 425                 430
Gly Thr Thr Thr His Phe Asp Lys Ile Gly Leu Glu Glu Glu Phe Arg
        435                 440                 445
Lys Leu Thr Asn Val Arg Ile Met Lys Glu Asn Met Arg Thr Gly Asn
    450                 455                 460
Leu Pro Ala Asn Met Lys Lys Ala Arg Val Ile Gln Ile Ile Pro Tyr
465                 470                 475                 480
Asp Phe Asn Arg Val Ile Leu Ser Met Lys Arg Gly Gln Glu Tyr Thr
                485                 490                 495
Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp Tyr
            500                 505                 510
Phe Ile Ala Thr Gln Gly Pro Leu Ala His Thr Val Glu Asp Phe Trp
        515                 520                 525
Arg Met Ile Trp Glu Trp Lys Ser His Thr Ile Val Met Leu Thr Glu
    530                 535                 540
Val Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln Tyr Trp Pro Thr Glu
545                 550                 555                 560
Gly Ser Val Thr His Gly Glu Ile Thr Ile Glu Ile Lys Asn Asp Thr
                565                 570                 575
Leu Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu Val Thr Leu Asn Gln
            580                 585                 590
Pro Gln Ala Arg Gln Glu Glu Gln Val Arg Val Val Arg Gln Phe His
        595                 600                 605
Phe His Gly Trp Pro Glu Ile Gly Ile Pro Ala Glu Gly Lys Gly Met
    610                 615                 620
Ile Asp Leu Ile Ala Ala Val Gln Lys Gln Gln Gln Gln Thr Gly Asn
625                 630                 635                 640
His Pro Ile Thr Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr
                645                 650                 655
Phe Ile Ala Leu Ser Asn Ile Leu Glu Arg Val Lys Ala Glu Gly Leu
            660                 665                 670
Leu Asp Val Phe Gln Ala Val Lys Ser Leu Arg Leu Gln Arg Pro His
        675                 680                 685
Met Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln
    690                 695                 700
Asp Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn Phe Lys
705                 710                 715

<210> 918
<211> 700
<212> PRT
<213> Homo sapiens

<400> 918
Met Glu Pro Leu Cys Pro Leu Leu Leu Val Gly Phe Ser Leu Pro Leu
 1               5                  10                  15
Ala Arg Ala Leu Arg Gly Asn Glu Thr Thr Ala Asp Ser Asn Glu Thr
            20                  25                  30
Thr Thr Thr Ser Gly Pro Pro Asp Pro Gly Ala Ser Gln Pro Leu Leu
        35                  40                  45
Ala Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Val Leu Leu Leu
    50                  55                  60
Ala Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val Ser
65                  70                  75                  80
Thr Ser Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu Gln
                85                  90                  95
Gln Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys Tyr
            100                 105                 110
Phe Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Ile Arg Ser
        115                 120                 125
Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu Phe Asn Ser Leu Pro Ser
    130                 135                 140
Gly His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn Arg
145                 150                 155                 160
Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Ser Arg Val
                165                 170                 175
Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn Ala
            180                 185                 190
Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala Gln
        195                 200                 205
Gly Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp Glu
    210                 215                 220
Gln Lys Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg Lys
225                 230                 235                 240
Glu Glu Lys Cys His Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr
                245                 250                 255
Gly Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp Tyr
            260                 265                 270
Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln Leu Pro Asp Gly Cys Lys
        275                 280                 285
Ala Pro Arg Leu Val Ser Gln Leu His Phe Thr Ser Trp Pro Asp Phe
    290                 295                 300
Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val
305                 310                 315                 320
Lys Thr Leu Asn Pro Val His Ala Gly Pro Ile Val Val His Cys Ser
                325                 330                 335
Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ala Met Met
            340                 345                 350
Ala Met Met His Ala Glu Gln Lys Val Asp Val Phe Glu Phe Val Ser
        355                 360                 365
Arg Ile Arg Asn Gln Arg Pro Gln Met Val Gln Thr Asp Met Gln Tyr
    370                 375                 380
Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr Tyr Leu Tyr Gly Asp Thr
385                 390                 395                 400
Glu Leu Asp Val Ser Ser Leu Glu Lys His Leu Gln Thr Met His Gly
                405                 410                 415
Thr Thr Thr His Phe Asp Lys Ile Gly Leu Glu Glu Glu Phe Arg Lys
            420                 425                 430
Leu Thr Asn Val Arg Ile Met Lys Glu Asn Met Arg Thr Gly Asn Leu
        435                 440                 445
Pro Ala Asn Met Lys Lys Ala Arg Val Ile Gln Ile Ile Pro Tyr Asp
    450                 455                 460
Phe Asn Arg Val Ile Leu Ser Met Lys Arg Gly Gln Glu Tyr Thr Asp
465                 470                 475                 480
Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp Tyr Phe
                485                 490                 495
Ile Ala Thr Gln Gly Pro Leu Ala His Thr Val Glu Asp Phe Trp Arg
            500                 505                 510
Met Ile Trp Glu Trp Lys Ser His Thr Ile Val Met Leu Thr Glu Val
        515                 520                 525
Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln Tyr Trp Pro Thr Glu Gly
    530                 535                 540
Ser Val Thr His Gly Glu Ile Thr Ile Glu Ile Lys Asn Asp Thr Leu
545                 550                 555                 560
Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu Val Thr Leu Asn Gln Pro
                565                 570                 575
Gln Ala Arg Gln Glu Glu Gln Val Arg Val Val Arg Gln Phe His Phe
            580                 585                 590
His Gly Trp Pro Glu Ile Gly Ile Pro Ala Glu Gly Lys Gly Met Ile
        595                 600                 605
Asp Leu Ile Ala Ala Val Gln Lys Gln Gln Gln Gln Thr Gly Asn His
    610                 615                 620
Pro Ile Thr Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe
625                 630                 635                 640
Ile Ala Leu Ser Asn Ile Leu Glu Arg Val Lys Ala Glu Gly Leu Leu
                645                 650                 655
Asp Val Phe Gln Ala Val Lys Ser Leu Arg Leu Gln Arg Pro His Met
            660                 665                 670
Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Asp
        675                 680                 685
Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn Phe Lys
    690                 695                 700

<210> 919
<211> 700
<212> PRT
<213> Homo sapiens

<400> 919
Met Glu Pro Leu Cys Pro Leu Leu Leu Val Gly Phe Ser Leu Pro Leu
 1               5                  10                  15
Ala Arg Ala Leu Arg Gly Asn Glu Thr Thr Ala Asp Ser Asn Glu Thr
            20                  25                  30
Thr Thr Thr Ser Gly Pro Pro Asp Pro Gly Ala Ser Gln Pro Leu Leu
        35                  40                  45
Ala Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Val Leu Leu Leu
    50                  55                  60
Ala Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val Ser
65                  70                  75                  80
Thr Ser Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu Gln
                85                  90                  95
Gln Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys Tyr
            100                 105                 110
Phe Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Ile Arg Ser
        115                 120                 125
Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu Phe Asn Ser Leu Pro Ser
    130                 135                 140
Gly His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn Arg
145                 150                 155                 160
Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Ser Arg Val
                165                 170                 175
Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn Ala
            180                 185                 190
Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala Gln
        195                 200                 205
Gly Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp Glu
    210                 215                 220
Gln Lys Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg Lys
225                 230                 235                 240
Glu Glu Lys Cys His Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr
                245                 250                 255
Gly Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp Tyr
            260                 265                 270
Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln Leu Pro Asp Gly Cys Lys
        275                 280                 285
Ala Pro Arg Leu Val Ser Gln Leu His Phe Thr Ser Trp Pro Asp Phe
    290                 295                 300
Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val
305                 310                 315                 320
Lys Thr Leu Asn Pro Val His Ala Gly Pro Ile Val Val His Cys Ser
                325                 330                 335
Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ala Met Met
            340                 345                 350
Ala Met Met His Ala Glu Gln Lys Val Asp Val Phe Glu Phe Val Ser
        355                 360                 365
Arg Ile Arg Asn Gln Arg Pro Gln Met Val Gln Thr Asp Met Gln Tyr
    370                 375                 380
Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr Tyr Leu Tyr Gly Asp Thr
385                 390                 395                 400
Glu Leu Asp Val Ser Ser Leu Glu Lys His Leu Gln Thr Met His Gly
                405                 410                 415
Thr Thr Thr His Phe Asp Lys Ile Gly Leu Glu Glu Glu Phe Arg Lys
            420                 425                 430
Leu Thr Asn Val Arg Ile Met Lys Glu Asn Met Arg Thr Gly Asn Leu
        435                 440                 445
Pro Ala Asn Met Lys Lys Ala Arg Val Ile Gln Ile Ile Pro Tyr Asp
    450                 455                 460
Phe Asn Arg Val Ile Leu Ser Met Lys Arg Gly Gln Glu Tyr Thr Asp
465                 470                 475                 480
Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp Tyr Phe
                485                 490                 495
Ile Ala Thr Gln Gly Pro Leu Ala His Thr Val Glu Asp Phe Trp Arg
            500                 505                 510
Met Ile Trp Glu Trp Lys Ser His Thr Ile Val Met Leu Thr Glu Val
        515                 520                 525
Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln Tyr Trp Pro Thr Glu Gly
    530                 535                 540
Ser Val Thr His Gly Glu Ile Thr Ile Glu Ile Lys Asn Asp Thr Leu
545                 550                 555                 560
Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu Val Thr Leu Asn Gln Pro
                565                 570                 575
Gln Ala Arg Gln Glu Glu Gln Val Arg Val Val Arg Gln Phe His Phe
            580                 585                 590
His Gly Trp Pro Glu Ile Gly Ile Pro Ala Glu Gly Lys Gly Met Ile
        595                 600                 605
Asp Leu Ile Ala Ala Val Gln Lys Gln Gln Gln Gln Thr Gly Asn His
    610                 615                 620
Pro Ile Thr Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe
625                 630                 635                 640
Ile Ala Leu Ser Asn Ile Leu Glu Arg Val Lys Ala Glu Gly Leu Leu
                645                 650                 655
Asp Val Phe Gln Ala Val Lys Ser Leu Arg Leu Gln Arg Pro His Met
            660                 665                 670
Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Asp
        675                 680                 685
Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn Phe Lys
    690                 695                 700

<210> 920
<211> 642
<212> PRT
<213> Homo sapiens

<400> 920
Met Ser Asn Arg Ser Ser Phe Ser Arg Leu Thr Trp Phe Arg Lys Gln
 1               5                  10                  15
Arg Lys Ala Val Val Ser Thr Ser Asp Lys Lys Met Pro Asn Gly Ile
            20                  25                  30
Leu Glu Glu Gln Glu Gln Gln Arg Val Met Leu Leu Ser Arg Ser Pro
        35                  40                  45
Ser Gly Pro Lys Lys Tyr Phe Pro Ile Pro Val Glu His Leu Glu Glu
    50                  55                  60
Glu Ile Arg Ile Arg Ser Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu
65                  70                  75                  80
Phe Asn Ser Leu Pro Ser Gly His Ile Gln Gly Thr Phe Glu Leu Ala
                85                  90                  95
Asn Lys Glu Glu Asn Arg Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro
            100                 105                 110
Asn Asp His Ser Arg Val Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys
        115                 120                 125
Ser Asp Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn
    130                 135                 140
Lys Phe Ile Ala Ala Gln Gly Pro Lys Gln Glu Thr Val Asn Asp Phe
145                 150                 155                 160
Trp Arg Met Val Trp Glu Gln Lys Ser Ala Thr Ile Val Met Leu Thr
                165                 170                 175
Asn Leu Lys Glu Arg Lys Glu Glu Lys Cys His Gln Tyr Trp Pro Asp
            180                 185                 190
Gln Gly Cys Trp Thr Tyr Gly Asn Ile Arg Val Cys Val Glu Asp Cys
        195                 200                 205
Val Val Leu Val Asp Tyr Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln
    210                 215                 220
Leu Pro Asp Gly Cys Lys Ala Pro Arg Leu Val Ser Gln Leu His Phe
225                 230                 235                 240
Thr Ser Trp Pro Asp Phe Gly Val Pro Phe Thr Pro Ile Gly Met Leu
                245                 250                 255
Lys Phe Leu Lys Lys Val Lys Thr Leu Asn Pro Val His Ala Gly Pro
            260                 265                 270
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile
        275                 280                 285
Val Ile Asp Ala Met Met Ala Met Met His Ala Glu Gln Lys Val Asp
    290                 295                 300
Val Phe Glu Phe Val Ser Arg Ile Arg Asn Gln Arg Pro Gln Met Val
305                 310                 315                 320
Gln Thr Asp Met Gln Tyr Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr
                325                 330                 335
Tyr Leu Tyr Gly Asp Thr Glu Leu Asp Val Ser Ser Leu Glu Lys His
            340                 345                 350
Leu Gln Thr Met His Gly Thr Thr Thr His Phe Asp Lys Ile Gly Leu
        355                 360                 365
Glu Glu Glu Phe Arg Lys Leu Thr Asn Val Arg Ile Met Lys Glu Asn
    370                 375                 380
Met Arg Thr Gly Asn Leu Pro Ala Asn Met Lys Lys Ala Arg Val Ile
385                 390                 395                 400
Gln Ile Ile Pro Tyr Asp Phe Asn Arg Val Ile Leu Ser Met Lys Arg
                405                 410                 415
Gly Gln Glu Tyr Thr Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr
            420                 425                 430
Arg Gln Lys Asp Tyr Phe Ile Ala Thr Gln Gly Pro Leu Ala His Thr
        435                 440                 445
Val Glu Asp Phe Trp Arg Met Ile Trp Asp Trp Lys Ser His Thr Ile
    450                 455                 460
Val Met Leu Thr Glu Val Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln
465                 470                 475                 480
Tyr Trp Pro Thr Glu Gly Ser Val Thr His Gly Glu Ile Thr Ile Glu
                485                 490                 495
Ile Lys Asn Asp Thr Leu Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu
            500                 505                 510
Val Thr Leu Asn Gln Pro Gln Ala Arg Gln Glu Glu Gln Val Arg Val
        515                 520                 525
Val Arg Gln Phe His Phe His Gly Trp Pro Glu Ile Gly Ile Pro Ala
    530                 535                 540
Glu Gly Lys Gly Met Ile Asp Leu Ile Ala Ala Val Gln Lys Gln Gln
545                 550                 555                 560
Gln Gln Thr Gly Asn His Pro Ile Thr Val His Cys Ser Ala Gly Ala
                565                 570                 575
Gly Arg Thr Gly Thr Phe Ile Ala Leu Ser Asn Ile Leu Glu Arg Val
            580                 585                 590
Lys Ala Glu Gly Leu Leu Asp Val Phe Gln Ala Val Lys Ser Leu Arg
        595                 600                 605
Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys
    610                 615                 620
Tyr Lys Val Val Gln Asp Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn
625                 630                 635                 640
Phe Lys


<210> 921
<211> 58
<212> PRT
<213> Homo sapiens

<400> 921
Glu His Asn Ala Glu Arg Ala Phe Leu Ala Gln Ala His Leu Gly Pro
 1               5                  10                  15
Gly Ala Pro Cys Thr Pro Gly Phe Pro Ser Phe Ile Pro Thr Gln Phe
            20                  25                  30
Pro Pro Phe Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr Ile
        35                  40                  45
Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly
    50                  55

<210> 922
<211> 17
<212> PRT
<213> Homo sapiens

<400> 922
Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Lys Glu Ser
 1               5                  10                  15
Pro


<210> 923
<211> 331
<212> PRT
<213> Homo sapiens

<400> 923
Met Glu Thr Val Ile Ser Ser Asp Ser Ser Pro Ala Val Glu Asn Glu
 1               5                  10                  15
His Pro Gln Glu Thr Pro Glu Ser Asn Asn Ser Val Tyr Thr Ser Phe
            20                  25                  30
Met Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu
        35                  40                  45
Val Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu
    50                  55                  60
Val Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln
65                  70                  75                  80
Ser Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His
                85                  90                  95
Arg Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His
            100                 105                 110
Lys Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro
        115                 120                 125
Leu Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser
    130                 135                 140
Leu Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser
145                 150                 155                 160
Gly Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu
                165                 170                 175
Lys Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser
            180                 185                 190
Leu Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg
        195                 200                 205
Thr Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg
    210                 215                 220
Val Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile
225                 230                 235                 240
Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn
                245                 250                 255
Asn Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr
            260                 265                 270
Phe Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Thr Ile
        275                 280                 285
Ile Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp
    290                 295                 300
Glu Asn Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln
305                 310                 315                 320
Ala Leu Val Leu Thr Gly Gly Glu Lys Lys Pro
                325                 330

<210> 924
<211> 331
<212> PRT
<213> Homo sapiens

<400> 924
Met Glu Thr Val Ile Ser Ser Asp Ser Ser Pro Ala Val Glu Asn Glu
 1               5                  10                  15
His Pro Gln Glu Thr Pro Glu Ser Asn Asn Ser Val Tyr Thr Ser Phe
            20                  25                  30
Met Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu
        35                  40                  45
Val Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu
    50                  55                  60
Val Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln
65                  70                  75                  80
Ser Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His
                85                  90                  95
Arg Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His
            100                 105                 110
Lys Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro
        115                 120                 125
Leu Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser
    130                 135                 140
Leu Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser
145                 150                 155                 160
Gly Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu
                165                 170                 175
Lys Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser
            180                 185                 190
Leu Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg
        195                 200                 205
Thr Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg
    210                 215                 220
Val Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile
225                 230                 235                 240
Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn
                245                 250                 255
Asn Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr
            260                 265                 270
Phe Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Thr Ile
        275                 280                 285
Ile Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp
    290                 295                 300
Glu Asn Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln
305                 310                 315                 320
Ala Leu Val Leu Thr Gly Gly Glu Lys Lys Pro
                325                 330

<210> 925
<211> 344
<212> PRT
<213> Homo sapiens

<400> 925
Ile Arg His Glu Arg Lys Pro Ser Arg Ala Pro Leu Ala Met Glu Thr
 1               5                  10                  15
Val Ile Ser Ser Asp Ser Ser Pro Ala Val Glu Asn Glu His Pro Gln
            20                  25                  30
Glu Thr Pro Glu Ser Asn Asn Ser Val Tyr Thr Ser Phe Met Lys Ser
        35                  40                  45
His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu Val Val Phe
    50                  55                  60
Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val Thr Asn
65                  70                  75                  80
Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln Ser Phe Val
                85                  90                  95
Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg Tyr Tyr
            100                 105                 110
Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His Lys Ile Glu
        115                 120                 125
Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro Leu Val Cys
    130                 135                 140
Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser Leu Ile Arg
145                 150                 155                 160
Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser Gly Asn Thr
                165                 170                 175
Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Lys Leu Phe
            180                 185                 190
Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser Leu Glu Glu
        195                 200                 205
Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg Thr Thr Thr
    210                 215                 220
Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg Val Ser Ala
225                 230                 235                 240
Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile Tyr Ser Lys
                245                 250                 255
Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn Leu Asp
            260                 265                 270
Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr Phe Glu Gly
        275                 280                 285
Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Thr Ile Ile Asn Arg
    290                 295                 300
Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp Glu Asn Asp
305                 310                 315                 320
Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln Ala Leu Val
                325                 330                 335
Leu Thr Gly Gly Glu Lys Lys Pro
            340

<210> 926
<211> 101
<212> PRT
<213> Homo sapiens

<400> 926
Met Glu Thr Val Ile Ser Ser Asp Ser Ser Pro Ala Val Glu Asn Glu
 1               5                  10                  15
His Pro Gln Glu Thr Pro Glu Ser Asn Asn Ser Val Tyr Thr Ser Phe
            20                  25                  30
Met Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu
        35                  40                  45
Val Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu
    50                  55                  60
Val Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln
65                  70                  75                  80
Ser Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His
                85                  90                  95
Arg Tyr Tyr Lys Ser
            100

<210> 927
<211> 331
<212> PRT
<213> Homo sapiens

<400> 927
Met Glu Thr Val Ile Ser Ser Asp Ser Ser Pro Ala Val Glu Asn Glu
 1               5                  10                  15
His Pro Gln Glu Thr Pro Glu Ser Asn Asn Ser Val Tyr Thr Ser Phe
            20                  25                  30
Met Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu
        35                  40                  45
Val Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu
    50                  55                  60
Val Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln
65                  70                  75                  80
Ser Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His
                85                  90                  95
Arg Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His
            100                 105                 110
Lys Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro
        115                 120                 125
Leu Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser
    130                 135                 140
Leu Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser
145                 150                 155                 160
Gly Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu
                165                 170                 175
Lys Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser
            180                 185                 190
Leu Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg
        195                 200                 205
Thr Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg
    210                 215                 220
Val Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile
225                 230                 235                 240
Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn
                245                 250                 255
Asn Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr
            260                 265                 270
Phe Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Thr Ile
        275                 280                 285
Ile Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp
    290                 295                 300
Glu Asn Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln
305                 310                 315                 320
Ala Leu Val Leu Thr Gly Gly Glu Lys Lys Pro
                325                 330

<210> 928
<211> 331
<212> PRT
<213> Homo sapiens

<400> 928
Met Glu Thr Val Ile Ser Ser Asp Ser Ser Pro Ala Val Glu Asn Glu
 1               5                  10                  15
His Pro Gln Glu Thr Pro Glu Ser Asn Asn Ser Val Tyr Thr Ser Phe
            20                  25                  30
Met Lys Ser His Arg Cys Tyr Asp Leu Ile Pro Thr Ser Ser Lys Leu
        35                  40                  45
Val Val Phe Asp Thr Ser Leu Gln Val Lys Lys Ala Phe Phe Ala Leu
    50                  55                  60
Val Thr Asn Gly Val Arg Ala Ala Pro Leu Trp Asp Ser Lys Lys Gln
65                  70                  75                  80
Ser Phe Val Gly Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His
                85                  90                  95
Arg Tyr Tyr Lys Ser Ala Leu Val Gln Ile Tyr Glu Leu Glu Glu His
            100                 105                 110
Lys Ile Glu Thr Trp Arg Glu Val Tyr Leu Gln Asp Ser Phe Lys Pro
        115                 120                 125
Leu Val Cys Ile Ser Pro Asn Ala Ser Leu Phe Asp Ala Val Ser Ser
    130                 135                 140
Leu Ile Arg Asn Lys Ile His Arg Leu Pro Val Ile Asp Pro Glu Ser
145                 150                 155                 160
Gly Asn Thr Leu Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu
                165                 170                 175
Lys Leu Phe Ile Thr Glu Phe Pro Lys Pro Glu Phe Met Ser Lys Ser
            180                 185                 190
Leu Glu Glu Leu Gln Ile Gly Thr Tyr Ala Asn Ile Ala Met Val Arg
        195                 200                 205
Thr Thr Thr Pro Val Tyr Val Ala Leu Gly Ile Phe Val Gln His Arg
    210                 215                 220
Val Ser Ala Leu Pro Val Val Asp Glu Lys Gly Arg Val Val Asp Ile
225                 230                 235                 240
Tyr Ser Lys Phe Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn
                245                 250                 255
Asn Leu Asp Val Ser Val Thr Lys Ala Leu Gln His Arg Ser His Tyr
            260                 265                 270
Phe Glu Gly Val Leu Lys Cys Tyr Leu His Glu Thr Leu Glu Thr Ile
        275                 280                 285
Ile Asn Arg Leu Val Glu Ala Glu Val His Arg Leu Val Val Val Asp
    290                 295                 300
Glu Asn Asp Val Val Lys Gly Ile Val Ser Leu Ser Asp Ile Leu Gln
305                 310                 315                 320
Ala Leu Val Leu Thr Gly Gly Glu Lys Lys Pro
                325                 330

<210> 929
<211> 1067
<212> PRT
<213> Homo sapiens

<400> 929
Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu Leu Ser Arg Leu Gly Ala
 1               5                  10                  15
Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn Val Ile Arg Lys Tyr Gly
            20                  25                  30
Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu Ala Met His Trp Gln Leu
        35                  40                  45
Gln Pro Glu Asp Lys Arg Leu Leu Leu Val Gly Ala Pro Arg Gly Glu
    50                  55                  60
Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr Gly Gly Leu Tyr Ser Cys
65                  70                  75                  80
Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg Ile Glu Phe Asp Asn Asp
                85                  90                  95
Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp Gln Trp Met Gly Val Thr
            100                 105                 110
Val Gln Ser Gln Gly Pro Gly Gly Lys Val Val Thr Cys Ala His Arg
        115                 120                 125
Tyr Glu Lys Arg Gln His Val Asn Thr Lys Gln Glu Ser Arg Asp Ile
    130                 135                 140
Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn Leu Arg Ile Glu Asp Asp
145                 150                 155                 160
Met Asp Gly Gly Asp Trp Ser Phe Cys Asp Gly Arg Leu Arg Gly His
                165                 170                 175
Glu Lys Phe Gly Ser Cys Gln Gln Gly Val Ala Ala Thr Phe Thr Lys
            180                 185                 190
Asp Phe His Tyr Ile Val Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys
        195                 200                 205
Gly Ile Val Arg Val Glu Gln Lys Asn Asn Thr Phe Phe Asp Met Asn
    210                 215                 220
Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly Gly Glu Thr Glu His Asp
225                 230                 235                 240
Glu Ser Leu Val Pro Val Pro Ala Asn Ser Tyr Leu Gly Phe Ser Leu
                245                 250                 255
Asp Ser Gly Lys Gly Ile Val Ser Lys Asp Glu Ile Thr Phe Val Ser
            260                 265                 270
Gly Ala Pro Arg Ala Asn His Ser Gly Ala Val Val Leu Leu Lys Arg
        275                 280                 285
Asp Met Lys Ser Ala His Leu Leu Pro Glu His Ile Phe Asp Gly Glu
    290                 295                 300
Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val Ala Val Val Asp Leu Asn
305                 310                 315                 320
Lys Asp Gly Trp Gln Asp Ile Val Ile Gly Ala Pro Gln Tyr Phe Asp
                325                 330                 335
Arg Asp Gly Glu Val Gly Gly Ala Val Tyr Val Tyr Met Asn Gln Gln
            340                 345                 350
Gly Arg Trp Asn Asn Val Lys Pro Ile Arg Leu Asn Gly Thr Lys Asp
        355                 360                 365
Ser Met Phe Gly Ile Ala Val Lys Asn Ile Gly Asp Ile Asn Gln Asp
    370                 375                 380
Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro Tyr Asp Asp Leu Gly Lys
385                 390                 395                 400
Val Phe Ile Tyr His Gly Ser Ala Asn Gly Ile Asn Thr Lys Pro Thr
                405                 410                 415
Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe Gly Tyr Ser Ile Ala Gly
            420                 425                 430
Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro Asp Val Ala Val Gly Ser
        435                 440                 445
Leu Ser Asp Ser Val Thr Ile Leu Arg Ser Arg Pro Val Ile Asn Ile
    450                 455                 460
Gln Lys Thr Ile Thr Val Thr Pro Asn Arg Ile Asp Leu Arg Gln Lys
465                 470                 475                 480
Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys Leu Gln Val Lys Ser Cys
                485                 490                 495
Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr Asn Pro Ser Ile Ser Ile
            500                 505                 510
Val Gly Thr Leu Glu Ala Glu Lys Glu Arg Arg Lys Ser Gly Leu Ser
        515                 520                 525
Ser Arg Val Gln Phe Arg Asn Gln Gly Ser Glu Pro Lys Tyr Thr Gln
    530                 535                 540
Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys Val Cys Met Glu Glu Thr
545                 550                 555                 560
Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys Leu Arg Pro Ile Pro Ile
                565                 570                 575
Thr Ala Ser Val Glu Ile Gln Glu Pro Ser Ser Arg Arg Arg Val Asn
            580                 585                 590
Ser Leu Pro Glu Val Leu Pro Ile Leu Asn Ser Asp Glu Pro Lys Thr
        595                 600                 605
Ala His Ile Asp Val His Phe Leu Lys Glu Gly Cys Gly Asp Asp Asn
    610                 615                 620
Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr Lys Phe Cys Thr Arg Glu
625                 630                 635                 640
Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro Ile Gln Lys Gly Val Pro
                645                 650                 655
Glu Leu Val Leu Lys Asp Gln Lys Asp Ile Ala Leu Glu Ile Thr Val
            660                 665                 670
Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro Thr Lys Asp Gly Asp Asp
        675                 680                 685
Ala His Glu Ala Lys Leu Ile Ala Thr Phe Pro Asp Thr Leu Thr Tyr
    690                 695                 700
Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro Glu Lys Gln Leu Ser Cys
705                 710                 715                 720
Val Ala Asn Gln Asn Gly Ser Gln Ala Asp Cys Glu Leu Gly Asn Pro
                725                 730                 735
Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr Leu Val Leu Ser Thr Thr
            740                 745                 750
Glu Val Thr Phe Asp Thr Pro Asp Leu Asp Ile Asn Leu Lys Leu Glu
        755                 760                 765
Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro Ile Thr Ala Lys Ala Lys
    770                 775                 780
Val Val Ile Glu Leu Leu Leu Ser Val Ser Gly Val Ala Lys Pro Ser
785                 790                 795                 800
Gln Val Tyr Phe Gly Gly Thr Val Val Gly Glu Gln Ala Met Lys Ser
                805                 810                 815
Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr Glu Phe Arg Val Ile Asn
            820                 825                 830
Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr Ala Thr Leu Asn Ile Gln
        835                 840                 845
Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp Leu Leu Tyr Leu Val Lys
    850                 855                 860
Val Glu Ser Lys Gly Leu Glu Lys Val Thr Cys Glu Pro Gln Lys Glu
865                 870                 875                 880
Ile Asn Ser Leu Asn Leu Thr Glu Ser His Asn Ser Arg Lys Lys Arg
                885                 890                 895
Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn Arg Lys Phe Ser Leu Phe
            900                 905                 910
Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys Ser Val Asn Val Asn Cys
        915                 920                 925
Val Asn Ile Arg Cys Pro Leu Arg Gly Leu Asp Ser Lys Ala Ser Leu
    930                 935                 940
Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr Phe Leu Glu Glu Tyr Ser
945                 950                 955                 960
Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg Ala Phe Ile Asp Val Thr
                965                 970                 975
Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn Ala Gly Thr Gln Val Arg
            980                 985                 990
Val Thr Val Phe Pro Ser Lys Thr Val Ala Gln Tyr Ser Gly Val Pro
        995                 1000                1005
Trp Trp Ile Ile Leu Val Ala Ile Leu Ala Gly Ile Leu Met Leu Ala
    1010                1015                1020
Leu Leu Val Phe Ile Leu Trp Lys Cys Gly Phe Phe Lys Arg Asn Lys
1025                1030                1035                1040
Lys Asp His Tyr Asp Ala Thr Tyr His Lys Ala Glu Ile His Ala Gln
                1045                1050                1055
Pro Ser Asp Lys Glu Arg Leu Thr Ser Asp Ala
            1060                1065

<210> 930
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 930
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60
Gly Ala Pro Arg Gly Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr
65                  70                  75                  80
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255
Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp
            260                 265                 270
Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala
        275                 280                 285
Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu
    290                 295                 300
His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val
305                 310                 315                 320
Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly
                325                 330                 335
Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr
            340                 345                 350
Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg
        355                 360                 365
Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile
    370                 375                 380
Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro
385                 390                 395                 400
Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly
                405                 410                 415
Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe
            420                 425                 430
Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro
        435                 440                 445
Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser
    450                 455                 460
Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg
465                 470                 475                 480
Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys
                485                 490                 495
Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr
            500                 505                 510
Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg
        515                 520                 525
Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser
    530                 535                 540
Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys
545                 550                 555                 560
Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys
                565                 570                 575
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
            580                 585                 590
Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn
        595                 600                 605
Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu
    610                 615                 620
Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr
625                 630                 635                 640
Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro
                645                 650                 655
Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile
            660                 665                 670
Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro
        675                 680                 685
Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe
    690                 695                 700
Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro
705                 710                 715                 720
Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp
                725                 730                 735
Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr
            740                 745                 750
Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Tyr Leu Asp
        755                 760                 765
Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro
    770                 775                 780
Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser
785                 790                 795                 800
Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly
                805                 810                 815
Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr
            820                 825                 830
Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr
        835                 840                 845
Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp
    850                 855                 860
Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr
865                 870                 875                 880
Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His
                885                 890                 895
Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn
            900                 905                 910
Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys
        915                 920                 925
Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu
    930                 935                 940
Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr
945                 950                 955                 960
Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg
                965                 970                 975
Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn
            980                 985                 990
Ala Gly Thr Gln Val Arg Val Thr Val Phe Pro Ser Lys Thr Val Ala
        995                 1000                1005
Gln Tyr Ser Gly Val Pro Trp Trp Ile Ile Leu Val Ala Ile Leu Ala
    1010                1015                1020
Gly Ile Leu Met Leu Ala Leu Leu Val Phe Ile Leu Trp Lys Cys Gly
1025                1030                1035                1040
Phe Phe Lys Arg Asn Lys Lys Asp His Tyr Asp Ala Thr Tyr His Lys
                1045                1050                1055
Ala Glu Ile His Ala Gln Pro Ser Asp Lys Glu Arg Leu Thr Ser Asp
            1060                1065                1070
Ala


<210> 931
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 931
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60
Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr
65                  70                  75                  80
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255
Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp
            260                 265                 270
Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala
        275                 280                 285
Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu
    290                 295                 300
His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val
305                 310                 315                 320
Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly
                325                 330                 335
Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr
            340                 345                 350
Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg
        355                 360                 365
Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile
    370                 375                 380
Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro
385                 390                 395                 400
Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly
                405                 410                 415
Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe
            420                 425                 430
Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro
        435                 440                 445
Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser
    450                 455                 460
Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg
465                 470                 475                 480
Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys
                485                 490                 495
Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr
            500                 505                 510
Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg
        515                 520                 525
Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser
    530                 535                 540
Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys
545                 550                 555                 560
Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys
                565                 570                 575
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
            580                 585                 590
Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn
        595                 600                 605
Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu
    610                 615                 620
Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr
625                 630                 635                 640
Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro
                645                 650                 655
Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile
            660                 665                 670
Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro
        675                 680                 685
Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe
    690                 695                 700
Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro
705                 710                 715                 720
Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp
                725                 730                 735
Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr
            740                 745                 750
Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Tyr Leu Asp
        755                 760                 765
Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro
    770                 775                 780
Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser
785                 790                 795                 800
Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly
                805                 810                 815
Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr
            820                 825                 830
Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr
        835                 840                 845
Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp
    850                 855                 860
Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr
865                 870                 875                 880
Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His
                885                 890                 895
Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn
            900                 905                 910
Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys
        915                 920                 925
Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu
    930                 935                 940
Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr
945                 950                 955                 960
Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg
                965                 970                 975
Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn
            980                 985                 990
Ala Gly Thr Gln Val Arg Val Thr Val Phe Pro Ser Lys Thr Val Ala
        995                 1000                1005
Gln Tyr Ser Gly Val Pro Trp Trp Ile Ile Leu Val Ala Ile Leu Ala
    1010                1015                1020
Gly Ile Leu Met Leu Ala Leu Leu Val Phe Ile Leu Trp Lys Cys Gly
1025                1030                1035                1040
Phe Phe Lys Arg Asn Lys Lys Asp His Tyr Asp Ala Thr Tyr His Lys
                1045                1050                1055
Ala Glu Ile His Ala Gln Pro Ser Asp Lys Glu Arg Leu Thr Ser Asp
            1060                1065                1070
Ala


<210> 932
<211> 553
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(553)
<223> Xaa = Any Amino Acid

<400> 932
Thr Leu Glu Ala Glu Lys Glu Arg Arg Lys Ser Gly Leu Ser Ser Arg
 1               5                  10                  15
Val Gln Phe Arg Asn Gln Gly Ser Glu Pro Lys Tyr Thr Gln Glu Leu
            20                  25                  30
Thr Leu Lys Arg Gln Lys Gln Lys Val Cys Met Glu Glu Thr Leu Trp
        35                  40                  45
Leu Gln Asp Asn Ile Arg Asp Lys Leu Arg Pro Ile Pro Ile Thr Ala
    50                  55                  60
Ser Val Glu Ile Gln Glu Pro Ser Ser Arg Arg Arg Val Asn Ser Leu
65                  70                  75                  80
Pro Glu Val Leu Pro Ile Leu Asn Ser Asp Glu Pro Lys Thr Ala His
                85                  90                  95
Ile Asp Val His Phe Leu Lys Glu Gly Cys Gly Asp Asp Asn Val Cys
            100                 105                 110
Asn Ser Asn Leu Lys Leu Glu Tyr Lys Phe Cys Thr Arg Glu Gly Asn
        115                 120                 125
Gln Asp Lys Phe Xaa Tyr Leu Pro Ile Gln Lys Gly Val Pro Glu Leu
    130                 135                 140
Val Leu Lys Asp Gln Lys Asp Ile Ala Leu Glu Ile Thr Val Thr Asn
145                 150                 155                 160
Ser Pro Ser Asn Pro Arg Asn Pro Thr Lys Asp Gly Asp Asp Ala His
                165                 170                 175
Glu Ala Lys Leu Ile Ala Thr Phe Pro Asp Thr Leu Thr Tyr Ser Ala
            180                 185                 190
Tyr Arg Glu Leu Arg Ala Phe Pro Glu Lys Gln Leu Ser Cys Val Ala
        195                 200                 205
Asn Gln Asn Gly Ser Gln Ala Asp Cys Glu Leu Gly Asn Pro Phe Lys
    210                 215                 220
Arg Asn Ser Asn Val Thr Phe Tyr Leu Val Leu Ser Thr Thr Glu Val
225                 230                 235                 240
Thr Phe Asp Thr Pro Asp Leu Asp Ile Asn Leu Lys Leu Glu Thr Thr
                245                 250                 255
Ser Asn Gln Asp Asn Leu Ala Pro Ile Thr Ala Lys Ala Lys Val Val
            260                 265                 270
Ile Glu Leu Leu Leu Ser Val Ser Gly Val Ala Lys Pro Ser Gln Val
        275                 280                 285
Tyr Phe Gly Gly Thr Val Val Gly Glu Gln Ala Met Lys Ser Glu Asp
    290                 295                 300
Glu Val Gly Ser Leu Ile Glu Tyr Glu Phe Arg Val Ile Asn Leu Gly
305                 310                 315                 320
Lys Pro Leu Thr Asn Leu Gly Thr Ala Thr Leu Asn Ile Gln Trp Pro
                325                 330                 335
Lys Glu Ile Ser Asn Gly Lys Trp Leu Leu Tyr Leu Val Lys Val Glu
            340                 345                 350
Ser Lys Gly Leu Glu Lys Val Thr Cys Glu Pro Gln Lys Glu Ile Asn
        355                 360                 365
Ser Leu Asn Leu Thr Glu Xaa His Asn Ser Arg Lys Lys Arg Glu Ile
    370                 375                 380
Thr Glu Lys Gln Ile Asp Asp Asn Arg Lys Phe Ser Leu Phe Ala Glu
385                 390                 395                 400
Arg Lys Tyr Gln Thr Leu Asn Cys Ser Val Asn Val Asn Cys Val Asn
                405                 410                 415
Ile Arg Cys Pro Leu Arg Gly Leu Asp Ser Lys Ala Ser Leu Ile Leu
            420                 425                 430
Arg Ser Arg Leu Trp Xaa Ser Thr Phe Leu Glu Glu Tyr Ser Lys Leu
        435                 440                 445
Asn Tyr Leu Asp Ile Leu Met Arg Ala Phe Ile Asp Val Thr Ala Ala
    450                 455                 460
Ala Glu Asn Ile Arg Leu Pro Asn Ala Gly Thr Gln Val Arg Val Thr
465                 470                 475                 480
Val Phe Pro Ser Lys Thr Val Ala Gln Tyr Ser Gly Val Pro Trp Trp
                485                 490                 495
Ile Ile Leu Val Ala Ile Leu Ala Gly Ile Leu Met Leu Ala Leu Leu
            500                 505                 510
Val Phe Ile Leu Trp Lys Cys Gly Phe Phe Lys Arg Asn Lys Lys Asp
        515                 520                 525
His Tyr Asp Ala Thr Tyr His Lys Ala Glu Ile His Ala Gln Pro Ser
    530                 535                 540
Asp Lys Glu Arg Xaa Thr Ser Asp Ala
545                 550

<210> 933
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 933
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60
Gly Ala Pro Arg Gly Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr
65                  70                  75                  80
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255
Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp
            260                 265                 270
Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala
        275                 280                 285
Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu
    290                 295                 300
His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val
305                 310                 315                 320
Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly
                325                 330                 335
Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr
            340                 345                 350
Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg
        355                 360                 365
Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile
    370                 375                 380
Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro
385                 390                 395                 400
Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly
                405                 410                 415
Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe
            420                 425                 430
Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro
        435                 440                 445
Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser
    450                 455                 460
Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg
465                 470                 475                 480
Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys
                485                 490                 495
Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr
            500                 505                 510
Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg
        515                 520                 525
Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser
    530                 535                 540
Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys
545                 550                 555                 560
Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys
                565                 570                 575
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
            580                 585                 590
Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn
        595                 600                 605
Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu
    610                 615                 620
Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr
625                 630                 635                 640
Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro
                645                 650                 655
Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile
            660                 665                 670
Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro
        675                 680                 685
Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe
    690                 695                 700
Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro
705                 710                 715                 720
Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp
                725                 730                 735
Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr
            740                 745                 750
Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp
        755                 760                 765
Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro
    770                 775                 780
Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser
785                 790                 795                 800
Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly
                805                 810                 815
Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr
            820                 825                 830
Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr
        835                 840                 845
Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp
    850                 855                 860
Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr
865                 870                 875                 880
Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His
                885                 890                 895
Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn
            900                 905                 910
Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys
        915                 920                 925
Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu
    930                 935                 940
Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr
945                 950                 955                 960
Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg
                965                 970                 975
Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn
            980                 985                 990
Ala Gly Thr Gln Val Arg Val Thr Val Phe Pro Ser Lys Thr Val Ala
        995                 1000                1005
Gln Tyr Ser Gly Val Pro Trp Trp Ile Ile Leu Val Ala Ile Leu Ala
    1010                1015                1020
Gly Ile Leu Met Leu Ala Leu Leu Val Phe Ile Leu Trp Lys Cys Gly
1025                1030                1035                1040
Phe Phe Lys Arg Asn Lys Lys Asp His Tyr Asp Ala Thr Tyr His Lys
                1045                1050                1055
Ala Glu Ile His Ala Gln Pro Ser Asp Lys Glu Arg Leu Thr Ser Asp
            1060                1065                1070
Ala


<210> 934
<211> 553
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(553)
<223> Xaa = Any Amino Acid

<400> 934
Thr Leu Glu Ala Glu Lys Glu Arg Arg Lys Ser Gly Leu Ser Ser Arg
 1               5                  10                  15
Val Gln Phe Arg Asn Gln Gly Ser Glu Pro Lys Tyr Thr Gln Glu Leu
            20                  25                  30
Thr Leu Lys Arg Gln Lys Gln Lys Val Cys Met Glu Glu Thr Leu Trp
        35                  40                  45
Leu Gln Asp Asn Ile Arg Asp Lys Leu Arg Pro Ile Pro Ile Thr Ala
    50                  55                  60
Ser Val Glu Ile Gln Glu Pro Ser Ser Arg Arg Arg Val Asn Ser Leu
65                  70                  75                  80
Pro Glu Val Leu Pro Ile Leu Asn Ser Asp Glu Pro Lys Thr Ala His
                85                  90                  95
Ile Asp Val His Phe Leu Lys Glu Gly Cys Gly Asp Asp Asn Val Cys
            100                 105                 110
Asn Ser Asn Leu Lys Leu Glu Tyr Lys Phe Cys Thr Arg Glu Gly Asn
        115                 120                 125
Xaa Asp Lys Phe Xaa Tyr Leu Pro Ile Gln Lys Gly Val Pro Glu Leu
    130                 135                 140
Val Leu Lys Asp Gln Lys Asp Ile Ala Leu Glu Ile Thr Val Thr Asn
145                 150                 155                 160
Ser Pro Ser Asn Pro Arg Asn Pro Thr Lys Asp Gly Asp Asp Ala His
                165                 170                 175
Glu Ala Lys Leu Ile Ala Thr Phe Pro Asp Thr Leu Thr Tyr Ser Ala
            180                 185                 190
Tyr Arg Glu Leu Arg Ala Phe Pro Glu Lys Gln Leu Ser Cys Val Ala
        195                 200                 205
Asn Gln Asn Gly Ser Gln Ala Asp Cys Glu Leu Gly Asn Pro Phe Lys
    210                 215                 220
Arg Asn Ser Asn Val Thr Phe Tyr Leu Val Leu Ser Thr Thr Glu Val
225                 230                 235                 240
Thr Phe Asp Thr Pro Asp Leu Asp Ile Asn Leu Lys Leu Glu Thr Thr
                245                 250                 255
Ser Asn Gln Asp Asn Leu Ala Pro Ile Thr Ala Lys Ala Lys Val Val
            260                 265                 270
Ile Glu Leu Leu Leu Ser Val Ser Gly Val Ala Lys Pro Ser Gln Val
        275                 280                 285
Tyr Phe Gly Gly Thr Val Val Gly Glu Gln Ala Met Lys Ser Glu Asp
    290                 295                 300
Glu Val Gly Ser Leu Ile Glu Tyr Glu Phe Arg Val Ile Asn Leu Gly
305                 310                 315                 320
Lys Pro Leu Thr Asn Leu Gly Thr Ala Thr Leu Asn Ile Gln Trp Pro
                325                 330                 335
Lys Glu Ile Ser Asn Gly Lys Trp Leu Leu Tyr Leu Val Lys Val Glu
            340                 345                 350
Ser Lys Gly Leu Glu Lys Val Thr Cys Glu Pro Gln Lys Glu Ile Asn
        355                 360                 365
Ser Leu Asn Leu Thr Glu Xaa His Asn Ser Arg Lys Lys Arg Glu Ile
    370                 375                 380
Thr Glu Lys Gln Ile Asp Asp Asn Arg Lys Phe Ser Leu Phe Ala Glu
385                 390                 395                 400
Arg Lys Tyr Gln Thr Leu Asn Cys Ser Val Asn Val Asn Cys Val Asn
                405                 410                 415
Ile Arg Cys Pro Leu Arg Gly Leu Asp Ser Lys Ala Ser Leu Ile Leu
            420                 425                 430
Arg Ser Arg Leu Trp Xaa Ser Thr Phe Leu Glu Glu Tyr Ser Lys Leu
        435                 440                 445
Asn Tyr Leu Asp Ile Leu Met Arg Ala Phe Ile Asp Val Thr Ala Ala
    450                 455                 460
Ala Glu Asn Ile Arg Leu Pro Asn Ala Gly Thr Gln Val Arg Val Thr
465                 470                 475                 480
Val Phe Pro Ser Lys Thr Val Ala Gln Tyr Ser Gly Val Pro Trp Trp
                485                 490                 495
Ile Ile Leu Val Ala Ile Leu Ala Gly Ile Leu Met Leu Ala Leu Leu
            500                 505                 510
Val Phe Ile Leu Trp Lys Cys Gly Phe Phe Lys Arg Asn Lys Lys Asp
        515                 520                 525
His Tyr Asp Ala Thr Tyr His Lys Ala Glu Ile His Ala Gln Pro Ser
    530                 535                 540
Asp Lys Glu Arg Xaa Thr Ser Asp Ala
545                 550

<210> 935
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 935
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60
Gly Ala Pro Arg Gly Glu Ala Leu Pro Leu Gln Arg Ala Phe Arg Thr
65                  70                  75                  80
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255
Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp
            260                 265                 270
Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala
        275                 280                 285
Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu
    290                 295                 300
His Ile Phe Asp Gly Gln Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val
305                 310                 315                 320
Ala Val Met Asp Leu Lys Lys Asp Gly Trp Gln Asp Ile Val Ile Gly
                325                 330                 335
Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr
            340                 345                 350
Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg
        355                 360                 365
Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile
    370                 375                 380
Arg Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro
385                 390                 395                 400
Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly
                405                 410                 415
Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe
            420                 425                 430
Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro
        435                 440                 445
Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser
    450                 455                 460
Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg
465                 470                 475                 480
Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys
                485                 490                 495
Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr
            500                 505                 510
Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg
        515                 520                 525
Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser
    530                 535                 540
Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys
545                 550                 555                 560
Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys
                565                 570                 575
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
            580                 585                 590
Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn
        595                 600                 605
Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu
    610                 615                 620
Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr
625                 630                 635                 640
Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro
                645                 650                 655
Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile
            660                 665                 670
Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro
        675                 680                 685
Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe
    690                 695                 700
Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro
705                 710                 715                 720
Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp
                725                 730                 735
Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr
            740                 745                 750
Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Tyr Leu Asp
        755                 760                 765
Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro
    770                 775                 780
Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser
785                 790                 795                 800
Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly
                805                 810                 815
Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr
            820                 825                 830
Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr
        835                 840                 845
Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp
    850                 855                 860
Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr
865                 870                 875                 880
Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His
                885                 890                 895
Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn
            900                 905                 910
Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys
        915                 920                 925
Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu
    930                 935                 940
Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr
945                 950                 955                 960
Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg
                965                 970                 975
Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Ser Leu Pro Asn
            980                 985                 990
Ala Gly Thr Gln Val Arg Val Thr Val Phe Pro Ser Lys Thr Val Ala
        995                 1000                1005
Gln Tyr Ser Gly Val Pro Trp Trp Ile Ile Leu Val Ala Ile Leu Ala
    1010                1015                1020
Gly Ile Leu Met Leu Ala Leu Leu Val Phe Ile Leu Trp Lys Cys Gly
1025                1030                1035                1040
Phe Phe Lys Arg Asn Lys Lys Asp His Tyr Asp Ala Thr Tyr His Lys
                1045                1050                1055
Ala Glu Ile His Ala Gln Pro Ser Asp Lys Glu Arg Leu Thr Ser Asp
            1060                1065                1070
Ala


<210> 936
<211> 1091
<212> PRT
<213> Homo sapiens

<400> 936
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60
Gly Ala Pro Arg Gly Glu Ala Leu Pro Leu Gln Arg Ala Phe Arg Thr
65                  70                  75                  80
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255
Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp
            260                 265                 270
Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala
        275                 280                 285
Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu
    290                 295                 300
His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val
305                 310                 315                 320
Ala Val Met Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly
                325                 330                 335
Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr
            340                 345                 350
Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg
        355                 360                 365
Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile
    370                 375                 380
Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro
385                 390                 395                 400
Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly
                405                 410                 415
Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe
            420                 425                 430
Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro
        435                 440                 445
Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser
    450                 455                 460
Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg
465                 470                 475                 480
Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys
                485                 490                 495
Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr
            500                 505                 510
Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg
        515                 520                 525
Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser
    530                 535                 540
Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys
545                 550                 555                 560
Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys
                565                 570                 575
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
            580                 585                 590
Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn
        595                 600                 605
Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu
    610                 615                 620
Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr
625                 630                 635                 640
Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro
                645                 650                 655
Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile
            660                 665                 670
Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro
        675                 680                 685
Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe
    690                 695                 700
Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro
705                 710                 715                 720
Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp
                725                 730                 735
Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr
            740                 745                 750
Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Tyr Leu Asp
        755                 760                 765
Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro
    770                 775                 780
Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser
785                 790                 795                 800
Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly
                805                 810                 815
Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr
            820                 825                 830
Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr
        835                 840                 845
Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp
    850                 855                 860
Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr
865                 870                 875                 880
Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His
                885                 890                 895
Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn
            900                 905                 910
Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys
        915                 920                 925
Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu
    930                 935                 940
Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr
945                 950                 955                 960
Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg
                965                 970                 975
Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn
            980                 985                 990
Ala Gly Thr Gln Val Arg Val Thr Val Phe Pro Ser Lys Thr Val Ala
        995                 1000                1005
Gln Tyr Ser Gly Val Pro Trp Trp Ile Ile Leu Val Ala Ile Leu Ala
    1010                1015                1020
Gly Ile Leu Met Leu Ala Leu Leu Val Phe Ile Leu Trp Lys Cys Gly
1025                1030                1035                1040
Phe Phe Lys Arg Ser Arg Tyr Asp Asp Ser Val Pro Arg Tyr His Ala
                1045                1050                1055
Val Arg Ile Arg Lys Glu Glu Arg Glu Ile Lys Asp Glu Lys Tyr Ile
            1060                1065                1070
Asp Asn Leu Glu Lys Lys Gln Trp Ile Thr Lys Trp Asn Arg Asn Glu
        1075                1080                1085
Ser Tyr Ser
    1090

<210> 937
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 937
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60
Gly Ala Pro Arg Gly Glu Ala Leu Pro Leu Gln Arg Ala Phe Arg Thr
65                  70                  75                  80
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255
Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp
            260                 265                 270
Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala
        275                 280                 285
Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu
    290                 295                 300
His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val
305                 310                 315                 320
Ala Val Met Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly
                325                 330                 335
Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr
            340                 345                 350
Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg
        355                 360                 365
Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile
    370                 375                 380
Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro
385                 390                 395                 400
Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly
                405                 410                 415
Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe
            420                 425                 430
Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro
        435                 440                 445
Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser
    450                 455                 460
Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg
465                 470                 475                 480
Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys
                485                 490                 495
Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr
            500                 505                 510
Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg
        515                 520                 525
Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser
    530                 535                 540
Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys
545                 550                 555                 560
Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys
                565                 570                 575
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
            580                 585                 590
Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn
        595                 600                 605
Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu
    610                 615                 620
Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr
625                 630                 635                 640
Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro
                645                 650                 655
Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile
            660                 665                 670
Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro
        675                 680                 685
Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe
    690                 695                 700
Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro
705                 710                 715                 720
Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp
                725                 730                 735
Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr
            740                 745                 750
Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Tyr Leu Asp
        755                 760                 765
Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro
    770                 775                 780
Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser
785                 790                 795                 800
Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly
                805                 810                 815
Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr
            820                 825                 830
Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr
        835                 840                 845
Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp
    850                 855                 860
Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr
865                 870                 875                 880
Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His
                885                 890                 895
Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn
            900                 905                 910
Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys
        915                 920                 925
Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu
    930                 935                 940
Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr
945                 950                 955                 960
Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg
                965                 970                 975
Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn
            980                 985                 990
Ala Gly Thr Gln Val Arg Val Thr Val Phe Pro Ser Lys Thr Val Ala
        995                 1000                1005
Gln Tyr Ser Gly Val Pro Trp Trp Ile Ile Leu Val Ala Ile Leu Ala
    1010                1015                1020
Gly Ile Leu Met Leu Ala Leu Leu Val Phe Ile Leu Trp Lys Cys Gly
1025                1030                1035                1040
Phe Phe Lys Arg Asn Lys Lys Asp His Tyr Asp Ala Thr Tyr His Lys
                1045                1050                1055
Ala Glu Ile His Ala Gln Pro Ser Asp Lys Glu Arg Leu Thr Ser Asp
            1060                1065                1070
Ala


<210> 938
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 938
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60
Gly Ala Pro Arg Gly Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr
65                  70                  75                  80
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255
Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp
            260                 265                 270
Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala
        275                 280                 285
Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu
    290                 295                 300
His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val
305                 310                 315                 320
Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly
                325                 330                 335
Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr
            340                 345                 350
Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg
        355                 360                 365
Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile
    370                 375                 380
Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro
385                 390                 395                 400
Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly
                405                 410                 415
Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe
            420                 425                 430
Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro
        435                 440                 445
Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser
    450                 455                 460
Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg
465                 470                 475                 480
Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys
                485                 490                 495
Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr
            500                 505                 510
Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg
        515                 520                 525
Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser
    530                 535                 540
Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys
545                 550                 555                 560
Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys
                565                 570                 575
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
            580                 585                 590
Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn
        595                 600                 605
Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu
    610                 615                 620
Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr
625                 630                 635                 640
Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro
                645                 650                 655
Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile
            660                 665                 670
Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro
        675                 680                 685
Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe
    690                 695                 700
Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro
705                 710                 715                 720
Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp
                725                 730                 735
Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr
            740                 745                 750
Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Tyr Leu Asp
        755                 760                 765
Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro
    770                 775                 780
Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser
785                 790                 795                 800
Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly
                805                 810                 815
Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr
            820                 825                 830
Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr
        835                 840                 845
Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp
    850                 855                 860
Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr
865                 870                 875                 880
Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His
                885                 890                 895
Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn
            900                 905                 910
Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys
        915                 920                 925
Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu
    930                 935                 940
Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr
945                 950                 955                 960
Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg
                965                 970                 975
Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn
            980                 985                 990
Ala Gly Thr Gln Val Arg Val Thr Val Phe Pro Ser Lys Thr Val Ala
        995                 1000                1005
Gln Tyr Ser Gly Val Pro Trp Trp Ile Ile Leu Val Ala Ile Leu Ala
    1010                1015                1020
Gly Ile Leu Met Leu Ala Leu Leu Val Phe Ile Leu Trp Lys Cys Gly
1025                1030                1035                1040
Phe Phe Lys Arg Asn Lys Lys Asp His Tyr Asp Ala Thr Tyr His Lys
                1045                1050                1055
Ala Glu Ile His Ala Gln Pro Ser Asp Lys Glu Arg Leu Thr Ser Asp
            1060                1065                1070
Ala


<210> 939
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 939
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60
Gly Ala Pro Arg Gly Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr
65                  70                  75                  80
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255
Tyr Leu Gly Leu Leu Phe Leu Thr Ser Val Ser Tyr Thr Asp Pro Asp
            260                 265                 270
Gln Phe Val Tyr Lys Thr Arg Pro Pro Arg Glu Gln Pro Asp Thr Phe
        275                 280                 285
Pro Asp Val Met Met Asn Ser Tyr Leu Gly Phe Ser Leu Asp Ser Gly
    290                 295                 300
Lys Gly Ile Val Ser Lys Asp Glu Ile Thr Phe Val Ser Gly Ala Pro
305                 310                 315                 320
Arg Ala Asn His Ser Gly Ala Val Val Leu Leu Lys Arg Asp Met Lys
                325                 330                 335
Ser Ala His Leu Leu Pro Glu His Ile Phe Asp Gly Glu Gly Leu Ala
            340                 345                 350
Ser Ser Phe Gly Tyr Asp Val Ala Val Val Asp Leu Asn Lys Asp Gly
        355                 360                 365
Trp Gln Asp Ile Val Ile Gly Ala Pro Gln Tyr Phe Asp Arg Asp Gly
    370                 375                 380
Glu Val Gly Gly Ala Val Tyr Val Tyr Met Asn Gln Gln Gly Arg Trp
385                 390                 395                 400
Asn Asn Val Lys Pro Ile Arg Leu Asn Gly Thr Lys Asp Ser Met Phe
                405                 410                 415
Gly Ile Ala Val Lys Asn Ile Gly Asp Ile Asn Gln Asp Gly Tyr Pro
            420                 425                 430
Asp Ile Ala Val Gly Ala Pro Tyr Asp Asp Leu Gly Lys Val Phe Ile
        435                 440                 445
Tyr His Gly Ser Ala Asn Gly Ile Asn Thr Lys Pro Thr Gln Val Leu
    450                 455                 460
Lys Gly Ile Ser Pro Tyr Phe Gly Tyr Ser Ile Ala Gly Asn Met Asp
465                 470                 475                 480
Leu Asp Arg Asn Ser Tyr Pro Asp Val Ala Val Gly Ser Leu Ser Asp
                485                 490                 495
Ser Val Thr Ile Phe Arg Ser Arg Pro Val Ile Asn Ile Gln Lys Thr
            500                 505                 510
Ile Thr Val Thr Pro Asn Arg Ile Asp Leu Arg Gln Lys Thr Ala Cys
        515                 520                 525
Gly Ala Pro Ser Gly Ile Cys Leu Gln Val Lys Ser Cys Phe Glu Tyr
    530                 535                 540
Thr Ala Asn Pro Ala Gly Tyr Asn Pro Ser Ile Ser Ile Val Gly Thr
545                 550                 555                 560
Leu Glu Ala Glu Lys Glu Arg Arg Lys Ser Gly Leu Ser Ser Arg Val
                565                 570                 575
Gln Phe Arg Asn Gln Gly Ser Glu Pro Lys Tyr Thr Gln Glu Leu Thr
            580                 585                 590
Leu Lys Arg Gln Lys Gln Lys Val Cys Met Glu Glu Thr Leu Trp Leu
        595                 600                 605
Gln Asp Asn Ile Arg Asp Lys Leu Arg Pro Ile Pro Ile Thr Ala Ser
    610                 615                 620
Val Glu Ile Gln Glu Pro Ser Ser Arg Arg Arg Val Asn Ser Leu Pro
625                 630                 635                 640
Glu Val Leu Pro Ile Leu Asn Ser Asp Glu Pro Lys Thr Ala His Ile
                645                 650                 655
Asp Val His Phe Leu Lys Glu Gly Cys Gly Asp Asp Asn Val Cys Asn
            660                 665                 670
Ser Asn Leu Lys Leu Glu Tyr Lys Phe Cys Thr Arg Glu Gly Asn Gln
        675                 680                 685
Asp Lys Phe Ser Tyr Leu Pro Ile Gln Lys Gly Val Pro Glu Leu Val
    690                 695                 700
Leu Lys Asp Gln Lys Asp Ile Ala Leu Glu Ile Thr Val Thr Asn Ser
705                 710                 715                 720
Pro Ser Asn Pro Arg Asn Pro Thr Lys Asp Gly Asp Asp Ala His Glu
                725                 730                 735
Ala Lys Leu Ile Ala Thr Phe Pro Asp Thr Leu Thr Tyr Ser Ala Tyr
            740                 745                 750
Arg Glu Leu Arg Ala Phe Pro Glu Lys Gln Leu Ser Cys Val Ala Asn
        755                 760                 765
Gln Asn Gly Ser Gln Ala Asp Cys Glu Leu Gly Asn Pro Phe Lys Arg
    770                 775                 780
Asn Ser Asn Val Thr Phe Tyr Leu Val Leu Ser Thr Thr Glu Val Thr
785                 790                 795                 800
Phe Asp Thr Pro Asp Leu Asp Ile Asn Leu Lys Leu Glu Thr Thr Ser
                805                 810                 815
Asn Gln Asp Asn Leu Ala Pro Ile Thr Ala Lys Ala Lys Val Val Ile
            820                 825                 830
Glu Leu Leu Leu Ser Val Ser Gly Val Ala Lys Pro Ser Gln Val Tyr
        835                 840                 845
Phe Gly Gly Thr Val Val Gly Glu Gln Ala Met Lys Ser Glu Asp Glu
    850                 855                 860
Val Gly Ser Leu Ile Glu Tyr Glu Phe Arg Val Ile Asn Leu Gly Lys
865                 870                 875                 880
Pro Leu Thr Asn Leu Gly Thr Ala Thr Leu Asn Ile Gln Trp Pro Lys
                885                 890                 895
Glu Ile Ser Asn Gly Lys Trp Leu Leu Tyr Leu Val Lys Val Glu Ser
            900                 905                 910
Lys Gly Leu Glu Lys Val Thr Cys Glu Pro Gln Lys Glu Ile Asn Ser
        915                 920                 925
Leu Asn Leu Thr Glu Ser His Asn Ser Arg Lys Lys Arg Glu Ile Thr
    930                 935                 940
Glu Lys Gln Ile Asp Asp Asn Arg Lys Phe Ser Leu Phe Ala Glu Arg
945                 950                 955                 960
Lys Tyr Gln Thr Leu Asn Cys Ser Val Asn Val Asn Cys Val Asn Ile
                965                 970                 975
Arg Cys Pro Leu Arg Gly Leu Asp Ser Lys Ala Ser Leu Ile Leu Arg
            980                 985                 990
Ser Arg Leu Trp Asn Ser Thr Phe Leu Glu Glu Tyr Ser Lys Leu Asn
        995                 1000                1005
Tyr Leu Asp Ile Leu Met Arg Ala Phe Ile Asp Val Thr Ala Ala Ala
    1010                1015                1020
Glu Asn Ile Arg Leu Pro Asn Ala Gly Thr Gln Val Arg Val Thr Val
1025                1030                1035                1040
Phe Pro Ser Lys Thr Val Ala Gln Tyr Ser Gly Val Pro Trp Trp Ile
                1045                1050                1055
Ile Leu Val Ala Ile Leu Ala Gly Ile Leu Met Leu Ala Leu Leu Val
            1060                1065                1070
Phe Ile Leu Trp Lys Cys Gly Phe Phe Lys Arg Ser Arg Tyr Asp Asp
        1075                1080                1085
Ser Val Pro Arg Tyr His Ala Val Arg Ile Arg Lys Glu Glu Arg Glu
    1090                1095                1100
Ile Lys Asp Glu Lys Tyr Ile Asp Asn Leu Glu Lys Lys Gln Trp Ile
1105                1110                1115                1120
Thr Lys Trp Asn Arg Asn Glu Ser Tyr Ser
                1125                1130

<210> 940
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 940
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 941
<211> 306
<212> PRT
<213> Homo sapiens

<400> 941
Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala
 1               5                  10                  15
Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Val
            20                  25                  30
Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly
        35                  40                  45
Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr
    50                  55                  60
Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu
65                  70                  75                  80
Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Leu Val Phe Asp Arg
                85                  90                  95
Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu
            100                 105                 110
Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala
        115                 120                 125
Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu
    130                 135                 140
Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys
145                 150                 155                 160
Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro
                165                 170                 175
Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn
            180                 185                 190
Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser
        195                 200                 205
Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys
    210                 215                 220
Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser
225                 230                 235                 240
Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg
                245                 250                 255
Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu
            260                 265                 270
Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His
        275                 280                 285
Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys
    290                 295                 300
Ser Ser
305

<210> 942
<211> 652
<212> PRT
<213> Homo sapiens

<400> 942
Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser
 1               5                  10                  15
Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His
            20                  25                  30
Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys
        35                  40                  45
Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe
    50                  55                  60
Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile
65                  70                  75                  80
Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110
Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125
Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp
    130                 135                 140
Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn
145                 150                 155                 160
Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp
                165                 170                 175
Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val
            180                 185                 190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe
        195                 200                 205
Ala Ala Tyr His Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp
    210                 215                 220
Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe
225                 230                 235                 240
Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255
Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser
            260                 265                 270
Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys
        275                 280                 285
Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn
    290                 295                 300
Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp
305                 310                 315                 320
Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys
                325                 330                 335
Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr
            340                 345                 350
Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile
        355                 360                 365
Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn
    370                 375                 380
Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr
385                 390                 395                 400
Phe His Pro Ser Val His Pro Met Ser Thr Ala Ser Gln Val Ala Ser
                405                 410                 415
Thr Trp Gly Asp Pro Phe Ser Ala Thr Val Asp Ala Val Asp Asp Ala
            420                 425                 430
Ile Pro Ser Leu Asn Pro Phe Leu Thr Lys Ser Ser Gly Asp Val His
        435                 440                 445
Leu Ser Ile Ser Ser Asp Val Ser Thr Phe Thr Thr Arg Thr Pro Thr
    450                 455                 460
His Glu Met Phe Val Gly Phe Thr Pro Ser Pro Val Ala Gln Pro His
465                 470                 475                 480
Pro Ser Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys
                485                 490                 495
Ser Thr Asn Val Ile Val Asp Ser Gly Gly Phe Asp Glu Leu Gly Gly
            500                 505                 510
Leu Leu Lys Pro Thr Val Ala Ser Gln Asn Gln Asn Leu Pro Val Ala
        515                 520                 525
Lys Leu Pro Pro Ser Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu
    530                 535                 540
Ala Asn Leu Val Gly Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn
545                 550                 555                 560
Asp Val Asn Trp Ser Gln Pro Gly Glu Lys Lys Leu Thr Gly Gly Ser
                565                 570                 575
Asn Cys Glu Pro Lys Val Ala Pro Thr Thr Ala Trp Asn Ala Ala Thr
            580                 585                 590
Met Ala Pro Pro Val Met Ala Tyr Pro Ala Thr Thr Pro Thr Gly Met
        595                 600                 605
Ile Gly Tyr Gly Ile Pro Pro Gln Met Gly Ser Val Pro Val Met Thr
    610                 615                 620
Gln Pro Thr Leu Ile Tyr Ser Gln Pro Val Met Arg Pro Pro Asn Pro
625                 630                 635                 640
Phe Gly Pro Val Ser Gly Ala Gln Ile Gln Phe Met
                645                 650

<210> 943
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 943
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Asp Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Pro Tyr Leu Cys Ser Val Cys Arg
            740                 745                 750
Pro Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu Gln Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Val Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Asp Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 944
<211> 907
<212> PRT
<213> Homo sapiens

<400> 944
Met Ser Gly Gln Thr Leu Thr Asp Arg Ile Ala Ala Ala Gln Tyr Ser
 1               5                  10                  15
Val Thr Gly Ser Ala Val Ala Arg Ala Val Cys Lys Ala Thr Thr His
            20                  25                  30
Glu Val Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Ala
        35                  40                  45
Thr Asn Glu Thr Asn Val Asn Ile Pro Gln Met Ala Asp Thr Leu Phe
    50                  55                  60
Glu Arg Ala Thr Asn Ser Ser Trp Val Val Val Phe Lys Ala Leu Val
65                  70                  75                  80
Thr Thr His His Leu Met Val His Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110
Ser Gly Ser His Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125
Arg Tyr Leu Asn Glu Lys Ala Phe Ser Tyr Arg Gln Met Ala Phe Asp
    130                 135                 140
Phe Ala Arg Val Lys Lys Gly Ala Asp Gly Val Met Arg Thr Met Ala
145                 150                 155                 160
Pro Glu Lys Leu Leu Lys Ser Met Pro Ile Leu Gln Gly Gln Ile Asp
                165                 170                 175
Ala Leu Leu Glu Phe Asp Val His Pro Asn Glu Leu Thr Asn Gly Val
            180                 185                 190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Leu Ile Lys Leu Phe
        195                 200                 205
Ala Cys Tyr Asn Asp Gly Val Ile Asn Leu Leu Glu Lys Phe Phe Glu
    210                 215                 220
Met Lys Lys Gly Gln Cys Lys Asp Ala Leu Glu Ile Tyr Lys Arg Phe
225                 230                 235                 240
Leu Thr Arg Met Thr Arg Val Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255
Val Gly Ile Asp Lys Gly Asp Ile Pro Asp Leu Thr Gln Ala Pro Ser
            260                 265                 270
Ser Leu Met Glu Thr Leu Glu Gln His Leu Asn Thr Leu Glu Gly Lys
        275                 280                 285
Lys Pro Gly Asn Asn Glu Gly Ser Gly Ala Pro Ser Pro Leu Ser Lys
    290                 295                 300
Ser Ser Pro Ala Thr Thr Val Thr Ser Pro Asn Ser Thr Pro Ala Lys
305                 310                 315                 320
Thr Ile Asp Thr Ser Pro Pro Val Asp Leu Phe Ala Thr Ala Ser Ala
                325                 330                 335
Ala Val Pro Val Ser Thr Ser Lys Pro Ser Ser Asp Leu Leu Asp Leu
            340                 345                 350
Gln Pro Asp Phe Ser Ser Gly Gly Ala Ala Ala Ala Ala Ala Pro Ala
        355                 360                 365
Pro Pro Pro Pro Ala Gly Gly Ala Thr Ala Trp Gly Asp Leu Leu Gly
    370                 375                 380
Glu Asp Ser Leu Ala Ala Leu Ser Ser Val Pro Ser Glu Ala Gln Ile
385                 390                 395                 400
Ser Asp Pro Phe Ala Pro Glu Pro Thr Pro Pro Thr Thr Thr Ala Glu
                405                 410                 415
Ile Ala Thr Ala Ser Ala Ser Ala Ser Thr Thr Thr Thr Val Thr Ala
            420                 425                 430
Val Thr Ala Glu Val Asp Leu Phe Gly Asp Ala Phe Ala Ala Ser Pro
        435                 440                 445
Gly Glu Ala Pro Ala Ala Ser Glu Gly Ala Ala Ala Pro Ala Thr Pro
    450                 455                 460
Thr Pro Val Ala Ala Ala Leu Asp Ala Cys Ser Gly Asn Asp Pro Phe
465                 470                 475                 480
Ala Pro Ser Glu Gly Ser Ala Glu Ala Ala Pro Glu Leu Asp Leu Phe
                485                 490                 495
Ala Met Lys Pro Pro Glu Thr Ser Val Pro Val Val Thr Pro Thr Ala
            500                 505                 510
Ser Thr Ala Pro Pro Val Pro Ala Thr Ala Pro Ser Pro Ala Pro Ala
        515                 520                 525
Val Ala Ala Ala Ala Ala Ala Thr Thr Ala Ala Thr Ala Ala Ala Thr
    530                 535                 540
Thr Thr Thr Thr Thr Ser Ala Ala Thr Ala Thr Thr Ala Pro Pro Ala
545                 550                 555                 560
Leu Asp Ile Phe Gly Asp Leu Phe Glu Ser Thr Pro Glu Val Ala Ala
                565                 570                 575
Ala Pro Lys Pro Asp Ala Ala Pro Ser Ile Asp Leu Phe Ser Thr Asp
            580                 585                 590
Ala Phe Ser Ser Pro Pro Gln Gly Ala Ser Pro Val Pro Glu Ser Ser
        595                 600                 605
Leu Thr Ala Asp Leu Leu Ser Val Asp Ala Phe Ala Ala Pro Ser Pro
    610                 615                 620
Ala Thr Thr Ala Ser Pro Ala Lys Val Asp Ser Ser Gly Val Ile Asp
625                 630                 635                 640
Leu Phe Gly Asp Ala Phe Gly Ser Ser Ala Ser Glu Pro Gln Pro Ala
                645                 650                 655
Ser Gln Ala Ala Ser Ser Ser Ser Ala Ser Ala Asp Leu Leu Ala Gly
            660                 665                 670
Phe Gly Gly Ser Phe Met Ala Pro Ser Pro Ser Pro Val Thr Pro Ala
        675                 680                 685
Gln Asn Asn Leu Leu Gln Pro Asn Phe Glu Ala Ala Phe Gly Thr Thr
    690                 695                 700
Pro Ser Thr Ser Ser Ser Ser Ser Phe Asp Pro Ser Val Phe Asp Gly
705                 710                 715                 720
Leu Gly Asp Leu Leu Met Pro Thr Met Ala Pro Ala Gly Gln Pro Ala
                725                 730                 735
Pro Val Ser Met Val Pro Pro Ser Pro Ala Met Ala Ala Ser Lys Ala
            740                 745                 750
Leu Gly Ser Asp Leu Asp Ser Ser Leu Ala Ser Leu Val Gly Asn Leu
        755                 760                 765
Gly Ile Ser Gly Thr Thr Thr Lys Lys Gly Asp Leu Gln Trp Asn Ala
    770                 775                 780
Gly Glu Lys Lys Leu Thr Gly Gly Ala Asn Trp Gln Pro Lys Val Ala
785                 790                 795                 800
Pro Ala Thr Trp Ser Ala Gly Val Pro Pro Ser Ala Pro Leu Gln Gly
                805                 810                 815
Ala Val Pro Pro Thr Ser Ser Val Pro Pro Val Ala Gly Ala Pro Ser
            820                 825                 830
Val Gly Gln Pro Gly Ala Gly Phe Gly Met Pro Pro Ala Gly Thr Gly
        835                 840                 845
Met Pro Met Met Pro Gln Gln Pro Val Met Phe Ala Gln Pro Met Met
    850                 855                 860
Arg Pro Pro Phe Gly Ala Ala Ala Val Pro Gly Thr Gln Leu Ser Pro
865                 870                 875                 880
Ser Pro Thr Pro Ala Ser Gln Ser Pro Lys Lys Pro Pro Ala Lys Asp
                885                 890                 895
Pro Leu Ala Asp Leu Asn Ile Lys Asp Phe Leu
            900                 905

<210> 945
<211> 1304
<212> PRT
<213> Homo sapiens

<400> 945
His Ala Gln Arg Pro Glu Met Gln Arg Gly Ala Ala Leu Cys Leu Arg
 1               5                  10                  15
Leu Trp Leu Cys Leu Gly Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser
            20                  25                  30
Met Thr Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val Ile Asp
        35                  40                  45
Thr Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro Leu Glu
    50                  55                  60
Trp Ala Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp
65                  70                  75                  80
Ser Glu Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp Ala Arg
                85                  90                  95
Pro Tyr Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn Asp Thr
            100                 105                 110
Gly Ser Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly
        115                 120                 125
Thr Thr Ala Ala Ser Ser Tyr Val Phe Val Arg Asp Phe Glu Gln Pro
    130                 135                 140
Phe Ile Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp Ala Met
145                 150                 155                 160
Trp Val Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Val Thr Leu Arg
                165                 170                 175
Ser Gln Ser Ser Val Leu Trp Pro Asp Gly Gln Glu Val Val Trp Asp
            180                 185                 190
Asp Arg Arg Gly Met Leu Val Ser Thr Pro Leu Leu His Asp Ala Leu
        195                 200                 205
Tyr Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn
    210                 215                 220
Pro Phe Leu Val His Ile Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu
225                 230                 235                 240
Leu Pro Arg Lys Ser Leu Glu Leu Leu Val Gly Glu Lys Leu Val Leu
                245                 250                 255
Asn Cys Thr Val Trp Ala Glu Phe Asn Ser Gly Val Thr Phe Asp Trp
            260                 265                 270
Asp Tyr Pro Gly Lys Gln Ala Glu Arg Gly Lys Trp Val Pro Glu Arg
        275                 280                 285
Arg Ser Gln Gln Thr His Thr Glu Leu Ser Ser Ile Leu Thr Ile His
    290                 295                 300
Asn Val Ser Gln His Asp Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn
305                 310                 315                 320
Gly Ile Gln Arg Phe Arg Glu Ser Thr Glu Val Ile Val His Glu Asn
                325                 330                 335
Pro Phe Ile Ser Val Glu Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr
            340                 345                 350
Ala Gly Asp Glu Leu Val Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro
        355                 360                 365
Pro Pro Glu Phe Gln Trp Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg
    370                 375                 380
His Ser Pro His Ala Leu Val Leu Lys Glu Val Thr Glu Ala Ser Thr
385                 390                 395                 400
Gly Thr Tyr Thr Leu Ala Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg
                405                 410                 415
Asn Ile Ser Leu Glu Leu Val Val Asn Val Pro Pro Gln Ile His Glu
            420                 425                 430
Lys Glu Ala Ser Ser Pro Ser Ile Tyr Ser Arg His Ser Arg Gln Ala
        435                 440                 445
Leu Thr Cys Thr Ala Tyr Gly Val Pro Leu Pro Leu Ser Ile Gln Trp
    450                 455                 460
His Trp Arg Pro Trp Thr Pro Cys Lys Met Phe Ala Gln Arg Ser Leu
465                 470                 475                 480
Arg Arg Arg Gln Gln Gln Asp Leu Met Pro Gln Cys Arg Asp Trp Arg
                485                 490                 495
Ala Val Thr Thr Gln Asp Ala Val Asn Pro Ile Glu Ser Leu Asp Thr
            500                 505                 510
Trp Thr Glu Phe Val Glu Gly Lys Asn Lys Thr Val Ser Lys Leu Val
        515                 520                 525
Ile Gln Asn Ala Asn Val Ser Ala Met Tyr Lys Cys Val Val Ser Asn
    530                 535                 540
Lys Val Gly Gln Asp Glu Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile
545                 550                 555                 560
Pro Asp Gly Phe Thr Ile Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu
                565                 570                 575
Gly Gln Pro Val Leu Leu Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu
            580                 585                 590
His Leu Arg Trp Tyr Arg Leu Asn Leu Ser Thr Leu His Asp Ala His
        595                 600                 605
Gly Asn Pro Leu Leu Leu Asp Cys Lys Asn Val His Leu Phe Ala Thr
    610                 615                 620
Pro Leu Ala Ala Ser Leu Glu Glu Val Ala Pro Gly Ala Arg His Ala
625                 630                 635                 640
Thr Leu Ser Leu Ser Ile Pro Arg Val Ala Pro Glu His Glu Gly His
                645                 650                 655
Tyr Val Cys Glu Val Gln Asp Arg Arg Ser His Asp Lys His Cys His
            660                 665                 670
Lys Lys Tyr Leu Ser Val Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln
        675                 680                 685
Asn Leu Thr Asp Leu Leu Val Asn Val Ser Asp Ser Leu Glu Met Gln
    690                 695                 700
Cys Leu Val Ala Gly Ala His Ala Pro Ser Ile Val Trp Tyr Lys Asp
705                 710                 715                 720
Glu Arg Leu Leu Glu Glu Lys Ser Gly Val Asp Leu Ala Asp Ser Asn
                725                 730                 735
Gln Lys Leu Ser Ile Gln Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr
            740                 745                 750
Leu Cys Ser Val Cys Asn Ala Lys Gly Cys Val Asn Ser Ser Ala Ser
        755                 760                 765
Val Ala Val Glu Gly Ser Glu Asp Lys Gly Ser Met Glu Ile Val Ile
    770                 775                 780
Leu Val Gly Thr Gly Val Ile Ala Val Phe Phe Trp Val Leu Leu Leu
785                 790                 795                 800
Leu Ile Phe Cys Asn Met Arg Arg Pro Ala His Ala Asp Ile Lys Thr
                805                 810                 815
Gly Tyr Leu Ser Ile Ile Met Asp Pro Gly Glu Val Pro Leu Glu Glu
            820                 825                 830
Gln Cys Glu Tyr Leu Ser Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg
        835                 840                 845
Glu Arg Leu His Leu Gly Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys
    850                 855                 860
Val Val Glu Ala Ser Ala Phe Gly Ile His Lys Gly Ser Ser Cys Asp
865                 870                 875                 880
Thr Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr Ala Ser Glu His
                885                 890                 895
Arg Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly Asn His
            900                 905                 910
Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro
        915                 920                 925
Leu Met Val Ile Val Glu Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe
    930                 935                 940
Leu Arg Ala Lys Arg Asp Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro
945                 950                 955                 960
Glu Gln Arg Gly Arg Phe Arg Ala Met Val Glu Leu Ala Arg Leu Asp
                965                 970                 975
Arg Arg Arg Pro Gly Ser Ser Asp Arg Val Leu Phe Ala Arg Phe Ser
            980                 985                 990
Lys Thr Glu Gly Gly Ala Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu
        995                 1000                1005
Asp Leu Trp Leu Ser Pro Leu Thr Met Glu Asp Leu Val Cys Tyr Ser
    1010                1015                1020
Phe Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Arg Lys Cys Ile
1025                1030                1035                1040
His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Ser Asp Val
                1045                1050                1055
Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro
            1060                1065                1070
Asp Tyr Val Arg Lys Gly Ser Ala Arg Leu Pro Leu Lys Trp Met Ala
        1075                1080                1085
Pro Glu Ser Ile Phe Asp Lys Val Tyr Thr Thr Gln Ser Asp Val Trp
    1090                1095                1100
Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro
1105                1110                1115                1120
Tyr Pro Gly Val Gln Ile Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp
                1125                1130                1135
Gly Thr Arg Met Arg Ala Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg
            1140                1145                1150
Ile Met Leu Asn Cys Trp Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe
        1155                1160                1165
Ser Glu Leu Val Glu Ile Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu
    1170                1175                1180
Gln Glu Glu Glu Glu Val Cys Met Ala Pro Arg Ser Ser Gln Ser Ser
1185                1190                1195                1200
Glu Glu Gly Ser Phe Ser Gln Val Ser Thr Met Ala Leu His Ile Ala
                1205                1210                1215
Gln Ala Asp Ala Glu Asp Ser Pro Pro Ser Leu Gln Arg His Ser Leu
            1220                1225                1230
Ala Ala Arg Tyr Tyr Asn Trp Val Ser Phe Pro Gly Cys Leu Ala Arg
        1235                1240                1245
Gly Ala Glu Thr Arg Gly Ser Ser Arg Met Lys Thr Phe Glu Glu Phe
    1250                1255                1260
Pro Met Thr Pro Thr Thr Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp
1265                1270                1275                1280
Ser Gly Met Val Leu Ala Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg
                1285                1290                1295
His Arg Gln Glu Ser Gly Phe Arg
            1300

<210> 946
<211> 306
<212> PRT
<213> Homo sapiens

<400> 946
Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala
 1               5                  10                  15
Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp
            20                  25                  30
Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly
        35                  40                  45
Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr
    50                  55                  60
Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu
65                  70                  75                  80
Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg
                85                  90                  95
Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu
            100                 105                 110
Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala
        115                 120                 125
Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu
    130                 135                 140
Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys
145                 150                 155                 160
Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro
                165                 170                 175
Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn
            180                 185                 190
Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser
        195                 200                 205
Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys
    210                 215                 220
Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser
225                 230                 235                 240
Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg
                245                 250                 255
Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu
            260                 265                 270
Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His
        275                 280                 285
Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys
    290                 295                 300
Ser Ser
305

<210> 947
<211> 902
<212> PRT
<213> Homo sapiens

<400> 947
Met Ser Gly Gln Thr Leu Thr Asp Arg Ile Ala Ala Ala Gln Tyr Ser
 1               5                  10                  15
Val Thr Gly Ser Ala Val Ala Arg Ala Val Cys Lys Ala Thr Thr His
            20                  25                  30
Glu Val Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Ala
        35                  40                  45
Thr Asn Glu Thr Asn Val Asn Ile Pro Gln Met Ala Asp Thr Leu Phe
    50                  55                  60
Glu Arg Ala Thr Asn Ser Ser Trp Val Val Val Phe Lys Ala Leu Val
65                  70                  75                  80
Thr Thr His His Leu Met Val His Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110
Ser Gly Ser His Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125
Arg Tyr Leu Asn Glu Lys Ala Phe Ser Tyr Arg Gln Met Ala Phe Asp
    130                 135                 140
Phe Ala Arg Val Lys Lys Gly Ala Asp Gly Val Met Arg Thr Met Ala
145                 150                 155                 160
Pro Glu Lys Leu Leu Lys Ser Met Pro Ile Leu Gln Gly Gln Ile Asp
                165                 170                 175
Ala Leu Leu Glu Phe Asp Val His Pro Asn Glu Leu Thr Asn Gly Val
            180                 185                 190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Leu Ile Lys Leu Phe
        195                 200                 205
Ala Cys Tyr Asn Asp Gly Val Ile Asn Leu Leu Glu Lys Phe Phe Glu
    210                 215                 220
Met Lys Lys Gly Gln Cys Lys Asp Ala Leu Glu Ile Tyr Lys Arg Phe
225                 230                 235                 240
Leu Thr Arg Met Thr Arg Val Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255
Val Gly Ile Asp Lys Gly Asp Ile Pro Asp Leu Thr Gln Ala Pro Ser
            260                 265                 270
Ser Leu Met Glu Thr Leu Glu Gln His Leu Asn Thr Leu Glu Gly Lys
        275                 280                 285
Lys Pro Gly Asn Lys Tyr Ala Ser Gly Ala Pro Ser Pro Leu Ser Lys
    290                 295                 300
Ser Ser Pro Ala Thr Thr Val Thr Ser Pro Asn Ser Thr Pro Ala Lys
305                 310                 315                 320
Thr Ile Asp Thr Ser Pro Pro Val Asp Leu Phe Ala Thr Ala Ser Ala
                325                 330                 335
Ala Val Pro Val Ser Thr Ser Lys Pro Ser Ser Asp Leu Leu Asp Leu
            340                 345                 350
Gln Pro Asp Phe Ser Ser Gly Gly Ala Ala Ala Ala Ala Ala Pro Ala
        355                 360                 365
Pro Pro Pro Pro Ala Gly Gly Ala Thr Ala Trp Gly Asp Ser Leu Ala
    370                 375                 380
Ala Leu Ser Ser Val Pro Ser Glu Ala Gln Ile Ser Asp Pro Phe Ala
385                 390                 395                 400
Pro Glu Pro Thr Pro Pro Thr Thr Thr Ala Glu Ile Ala Thr Ala Ser
                405                 410                 415
Ala Ser Ala Ser Thr Thr Thr Thr Val Thr Ala Val Thr Ala Glu Val
            420                 425                 430
Asp Leu Phe Gly Asp Ala Phe Ala Ala Ser Pro Gly Glu Ala Pro Ala
        435                 440                 445
Ala Ser Glu Gly Ala Ala Ala Pro Ala Thr Pro Thr Pro Val Ala Ala
    450                 455                 460
Ala Leu Asp Ala Cys Ser Gly Asn Asp Pro Phe Ala Pro Ser Glu Gly
465                 470                 475                 480
Ser Ala Glu Ala Ala Pro Glu Leu Asp Leu Phe Ala Met Lys Pro Pro
                485                 490                 495
Glu Thr Ser Val Pro Val Val Thr Pro Thr Ala Ser Thr Ala Pro Pro
            500                 505                 510
Val Pro Ala Thr Ala Pro Ser Pro Ala Pro Ala Val Ala Ala Ala Ala
        515                 520                 525
Ala Ala Thr Thr Ala Ala Thr Ala Ala Ala Thr Thr Thr Thr Thr Thr
    530                 535                 540
Ser Ala Ala Thr Ala Thr Thr Ala Pro Pro Ala Leu Asp Ile Phe Gly
545                 550                 555                 560
Asp Leu Phe Glu Ser Thr Pro Glu Val Ala Ala Ala Pro Lys Pro Asp
                565                 570                 575
Ala Ala Pro Ser Ile Asp Leu Phe Ser Thr Asp Ala Phe Ser Ser Pro
            580                 585                 590
Pro Gln Gly Ala Ser Pro Val Pro Glu Ser Ser Leu Thr Ala Asp Leu
        595                 600                 605
Leu Ser Val Asp Ala Phe Ala Ala Pro Ser Pro Ala Thr Thr Ala Ser
    610                 615                 620
Pro Ala Lys Val Asp Ser Ser Gly Val Ile Asp Leu Phe Gly Asp Ala
625                 630                 635                 640
Phe Gly Ser Ser Ala Ser Glu Pro Gln Pro Ala Ser Gln Ala Ala Ser
                645                 650                 655
Ser Ser Ser Ala Ser Ala Asp Leu Leu Ala Gly Phe Gly Gly Ser Phe
            660                 665                 670
Met Ala Pro Ser Pro Ser Pro Val Thr Pro Ala Gln Asn Asn Leu Leu
        675                 680                 685
Gln Pro Asn Phe Glu Ala Ala Phe Gly Thr Thr Pro Ser Thr Ser Ser
    690                 695                 700
Ser Ser Ser Phe Asp Pro Ser Val Phe Asp Gly Leu Gly Asp Leu Leu
705                 710                 715                 720
Met Pro Thr Met Ala Pro Ala Gly Gln Pro Ala Pro Val Ser Met Val
                725                 730                 735
Pro Pro Ser Pro Ala Met Ala Ala Ser Lys Ala Leu Gly Ser Asp Leu
            740                 745                 750
Asp Ser Ser Leu Ala Ser Leu Val Gly Asn Leu Gly Ile Ser Gly Thr
        755                 760                 765
Thr Thr Lys Lys Gly Asp Leu Gln Trp Asn Ala Gly Glu Lys Lys Leu
    770                 775                 780
Thr Gly Gly Ala Asn Trp Gln Pro Lys Val Ala Pro Ala Thr Trp Ser
785                 790                 795                 800
Ala Gly Val Pro Pro Ser Ala Pro Leu Gln Gly Ala Val Pro Pro Thr
                805                 810                 815
Ser Ser Val Pro Pro Val Ala Gly Ala Pro Ser Val Gly Gln Pro Gly
            820                 825                 830
Ala Gly Phe Gly Met Pro Pro Ala Gly Thr Gly Met Pro Met Met Pro
        835                 840                 845
Gln Gln Pro Val Met Phe Ala Gln Pro Met Met Arg Pro Pro Phe Gly
    850                 855                 860
Ala Ala Ala Val Pro Gly Thr Gln Leu Ser Pro Ser Pro Thr Pro Ala
865                 870                 875                 880
Ser Gln Ser Pro Lys Lys Pro Pro Ala Lys Asp Pro Leu Ala Asp Leu
                885                 890                 895
Asn Ile Lys Asp Phe Leu
            900

<210> 948
<211> 1363
<212> PRT
<213> Homo sapiens

<400> 948
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Ser Cys Lys Gly Pro Gly Gln Asn Val Ala Val Thr Arg Ala His
            1300                1305                1310
Pro Asp Ser Gln Gly Arg Arg Arg Arg Pro Glu Arg Gly Ala Arg Gly
        1315                1320                1325
Gly Gln Val Phe Tyr Asn Ser Glu Tyr Gly Glu Leu Ser Glu Pro Ser
    1330                1335                1340
Glu Glu Asp His Cys Ser Pro Ser Ala Arg Val Thr Phe Phe Thr Asp
1345                1350                1355                1360
Asn Ser Tyr


<210> 949
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 949
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Asp Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Lys Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Pro Tyr Leu Cys Ser Val Cys Arg
            740                 745                 750
Pro Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu Gln Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Val Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Asp Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Phe Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 950
<211> 1363
<212> PRT
<213> Homo sapiens

<400> 950
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Ser Cys Lys Gly Pro Gly Gln Asn Val Ala Val Thr Arg Ala His
            1300                1305                1310
Pro Asp Ser Gln Gly Arg Arg Arg Arg Pro Glu Arg Gly Ala Arg Gly
        1315                1320                1325
Gly Gln Val Phe Tyr Asn Ser Glu Tyr Gly Glu Leu Ser Glu Pro Ser
    1330                1335                1340
Glu Glu Asp His Cys Ser Pro Ser Ala Arg Val Thr Phe Phe Thr Asp
1345                1350                1355                1360
Asn Ser Tyr


<210> 951
<211> 1363
<212> PRT
<213> Homo sapiens

<400> 951
Met Gln Pro Gly Ala Ala Leu Asn Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Gln Gly Leu Ala Asn Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Asp Ser Tyr Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Thr Trp Pro Gly Ala
    50                  55                  60
Gln Glu Val Leu Thr Thr Gly Gly Lys Asp Ser Glu Asp Thr Arg Val
65                  70                  75                  80
Val His Asp Cys Glu Gly Thr Glu Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu Ala Gln Thr His Ala Asn Asn Thr Gly Ser Tyr His Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Thr
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Lys His Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ser Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Ile Thr Leu Arg Ser Gln Ser Ser Ala Leu
                165                 170                 175
His Pro Asp Gly Gln Glu Val Leu Trp Asp Asp Arg Arg Gly Met Arg
            180                 185                 190
Val Pro Thr Gln Leu Leu Arg Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asn Phe Leu Ser Asn Leu Phe Val Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Tyr Pro Lys Lys Ser Met
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asp Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Ala Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln Asn Asp
    290                 295                 300
Leu Gly Pro Tyr Val Cys Glu Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Lys Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Val Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Arg Lys Ala Val Thr Gly Arg His Asn Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Ala Gly Val Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Gln Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro His Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Thr Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Gln Pro Leu Ser Val Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Thr Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Arg
465                 470                 475                 480
Asp Gly Met Pro Gln Cys Arg Asp Trp Lys Glu Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Ser Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asp Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Val Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Ser Ile
545                 550                 555                 560
Glu Ser Glu Pro Ser Glu Asp Pro Leu Glu Gly Gln Ser Val Arg Leu
                565                 570                 575
Ser Cys Arg Ala Asp Asn Tyr Thr Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala Gln Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Glu Ala Asn Leu
    610                 615                 620
Glu Glu Ala Glu Pro Gly Ala Arg His Ala Thr Leu Ser Leu Asn Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu Asp Glu Gly Asp Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser Gln Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Arg Cys Pro Val Ala Gly Ala
    690                 695                 700
His Val Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Lys
705                 710                 715                 720
Glu Ser Gly Ile Asp Leu Ala Asp Ser Asn Gln Arg Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Ile Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Lys Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly His Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile Asn Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Asn Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Val Lys Arg Asp
    930                 935                 940
Thr Phe Asn Pro Tyr Ala Glu Lys Ser Pro Glu Gln Arg Arg Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Gly Ala Lys Ala Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Ala Leu Phe Thr Arg Phe Leu Met Gly Lys Gly Ser Ala
            980                 985                 990
Arg Arg Ala Pro Leu Val Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Ile Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Lys Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Gln Ser Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Asp Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Gly Gly Trp Gln Glu Glu Glu Glu Glu
    1170                1175                1180
Arg Met Ala Leu His Ser Ser Gln Ser Ser Glu Glu Asp Gly Phe Met
1185                1190                1195                1200
Gln Ala Ser Thr Thr Ala Leu His Ile Thr Glu Ala Asp Ala Asp Asp
                1205                1210                1215
Ser Pro Pro Ser Met His Cys His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Cys Val Ser Phe Pro Gly Arg Leu Ala Arg Gly Thr Lys Thr Pro Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Leu Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Ala Ser Met Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Glu Leu Glu Ser Arg His Arg Pro Glu Gly Ser
                1285                1290                1295
Phe Ser Cys Lys Gly Pro Gly Gln His Met Asp Ile Pro Arg Gly His
            1300                1305                1310
Pro Asp Pro Gln Gly Arg Arg Arg Arg Pro Thr Gln Gly Ala Gln Gly
        1315                1320                1325
Gly Lys Val Phe Tyr Asn Asn Glu Tyr Gly Glu Val Ser Gln Pro Cys
    1330                1335                1340
Thr Glu Gly Asp Cys Cys Pro Ser Ala Gly Ser Thr Phe Phe Ala Asp
1345                1350                1355                1360
Ser Ser Tyr


<210> 952
<211> 306
<212> PRT
<213> Homo sapiens

<400> 952
Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala
 1               5                  10                  15
Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp
            20                  25                  30
Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly
        35                  40                  45
Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr
    50                  55                  60
Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu
65                  70                  75                  80
Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg
                85                  90                  95
Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu
            100                 105                 110
Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala
        115                 120                 125
Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu
    130                 135                 140
Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys
145                 150                 155                 160
Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro
                165                 170                 175
Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn
            180                 185                 190
Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser
        195                 200                 205
Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys
    210                 215                 220
Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser
225                 230                 235                 240
Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg
                245                 250                 255
Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu
            260                 265                 270
Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His
        275                 280                 285
Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys
    290                 295                 300
Ser Ser
305

<210> 953
<211> 306
<212> PRT
<213> Homo sapiens

<400> 953
Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala
 1               5                  10                  15
Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Val
            20                  25                  30
Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly
        35                  40                  45
Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr
    50                  55                  60
Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu
65                  70                  75                  80
Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Leu Val Phe Asp Arg
                85                  90                  95
Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu
            100                 105                 110
Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala
        115                 120                 125
Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu
    130                 135                 140
Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys
145                 150                 155                 160
Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro
                165                 170                 175
Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn
            180                 185                 190
Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser
        195                 200                 205
Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys
    210                 215                 220
Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser
225                 230                 235                 240
Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg
                245                 250                 255
Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu
            260                 265                 270
Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His
        275                 280                 285
Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys
    290                 295                 300
Ser Ser
305

<210> 954
<211> 306
<212> PRT
<213> Homo sapiens

<400> 954
Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala
 1               5                  10                  15
Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp
            20                  25                  30
Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly
        35                  40                  45
Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr
    50                  55                  60
Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu
65                  70                  75                  80
Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg
                85                  90                  95
Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu
            100                 105                 110
Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala
        115                 120                 125
Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu
    130                 135                 140
Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys
145                 150                 155                 160
Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro
                165                 170                 175
Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn
            180                 185                 190
Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser
        195                 200                 205
Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys
    210                 215                 220
Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser
225                 230                 235                 240
Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg
                245                 250                 255
Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu
            260                 265                 270
Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His
        275                 280                 285
Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys
    290                 295                 300
Ser Ser
305

<210> 955
<211> 337
<212> PRT
<213> Homo sapiens

<400> 955
Gly Pro Ser Leu Leu Gly Thr Arg Gly Thr Pro Asn Pro Ala Arg Thr
 1               5                  10                  15
Leu Gln Ile Phe Phe Leu Ile Ile Gly Arg Arg Leu Thr Gly Arg Met
            20                  25                  30
Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala Thr
        35                  40                  45
Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp Pro
    50                  55                  60
Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly Arg
65                  70                  75                  80
Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr Glu
                85                  90                  95
Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu Tyr
            100                 105                 110
Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg Ile
        115                 120                 125
Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu Tyr
    130                 135                 140
Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala Thr
145                 150                 155                 160
Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu Ile
                165                 170                 175
His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys Val
            180                 185                 190
Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro Leu
        195                 200                 205
Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn Ile
    210                 215                 220
Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser Leu
225                 230                 235                 240
Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro His Lys Ala
                245                 250                 255
Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser Leu
            260                 265                 270
Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg Val
        275                 280                 285
Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu Ser
    290                 295                 300
Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His Leu
305                 310                 315                 320
Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys Ser
                325                 330                 335
Ser


<210> 956
<211> 306
<212> PRT
<213> Homo sapiens

<400> 956
Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala
 1               5                  10                  15
Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp
            20                  25                  30
Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly
        35                  40                  45
Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr
    50                  55                  60
Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu
65                  70                  75                  80
Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg
                85                  90                  95
Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu
            100                 105                 110
Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala
        115                 120                 125
Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu
    130                 135                 140
Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys
145                 150                 155                 160
Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro
                165                 170                 175
Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn
            180                 185                 190
Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser
        195                 200                 205
Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys
    210                 215                 220
Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser
225                 230                 235                 240
Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg
                245                 250                 255
Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu
            260                 265                 270
Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His
        275                 280                 285
Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys
    290                 295                 300
Ser Ser
305

<210> 957
<211> 337
<212> PRT
<213> Homo sapiens

<400> 957
Gly Pro Ser Leu Leu Gly Thr Arg Gly Thr Pro Asn Pro Ala Arg Thr
 1               5                  10                  15
Leu Gln Ile Phe Phe Leu Ile Ile Gly Arg Arg Leu Thr Gly Arg Met
            20                  25                  30
Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala Thr
        35                  40                  45
Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp Pro
    50                  55                  60
Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly Arg
65                  70                  75                  80
Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr Glu
                85                  90                  95
Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu Tyr
            100                 105                 110
Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg Ile
        115                 120                 125
Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu Tyr
    130                 135                 140
Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala Thr
145                 150                 155                 160
Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu Ile
                165                 170                 175
His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys Val
            180                 185                 190
Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro Leu
        195                 200                 205
Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn Ile
    210                 215                 220
Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser Leu
225                 230                 235                 240
Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro His Lys Ala
                245                 250                 255
Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser Leu
            260                 265                 270
Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg Val
        275                 280                 285
Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu Ser
    290                 295                 300
Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His Leu
305                 310                 315                 320
Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys Ser
                325                 330                 335
Ser


<210> 958
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 958
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 959
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 959
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 960
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 960
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 961
<211> 1363
<212> PRT
<213> Homo sapiens

<400> 961
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Ser Cys Lys Gly Pro Gly Gln Asn Val Ala Val Thr Arg Ala His
            1300                1305                1310
Pro Asp Ser Gln Gly Arg Arg Arg Arg Pro Glu Arg Gly Ala Arg Gly
        1315                1320                1325
Gly Gln Val Phe Tyr Asn Ser Glu Tyr Gly Glu Leu Ser Glu Pro Ser
    1330                1335                1340
Glu Glu Asp His Cys Ser Pro Ser Ala Arg Val Thr Phe Phe Thr Asp
1345                1350                1355                1360
Asn Ser Tyr


<210> 962
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 962
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 963
<211> 1363
<212> PRT
<213> Homo sapiens

<400> 963
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Ser Cys Lys Gly Pro Gly Gln Asn Val Ala Val Thr Arg Ala His
            1300                1305                1310
Pro Asp Ser Gln Gly Arg Arg Arg Arg Pro Glu Arg Gly Ala Arg Gly
        1315                1320                1325
Gly Gln Val Phe Tyr Asn Ser Glu Tyr Gly Glu Leu Ser Glu Pro Ser
    1330                1335                1340
Glu Glu Asp His Cys Ser Pro Ser Ala Arg Val Thr Phe Phe Thr Asp
1345                1350                1355                1360
Asn Ser Tyr


<210> 964
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 964
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Asp Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Pro Tyr Leu Cys Ser Val Cys Arg
            740                 745                 750
Pro Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu Gln Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Val Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Asp Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 965
<211> 40
<212> PRT
<213> Homo sapiens

<400> 965
Val Glu Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys
 1               5                  10                  15
Arg Asp Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly
            20                  25                  30
Arg Phe Arg Ala Met Val Glu Leu
        35                  40

<210> 966
<211> 23
<212> PRT
<213> Homo sapiens

<400> 966
Gly Val Glu Phe Ser Lys Phe Gly Asn Leu Ser Asn Phe Leu Arg Ala
 1               5                  10                  15
Lys Arg Asn Leu Phe Val Pro
            20

<210> 967
<211> 17
<212> PRT
<213> Homo sapiens

<400> 967
Gly Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asn Leu Phe Val
 1               5                  10                  15
Pro


<210> 968
<211> 16
<212> PRT
<213> Homo sapiens

<400> 968
Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asn Leu Phe Val Pro
 1               5                  10                  15

<210> 969
<211> 306
<212> PRT
<213> Homo sapiens

<400> 969
Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala
 1               5                  10                  15
Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp
            20                  25                  30
Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly
        35                  40                  45
Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr
    50                  55                  60
Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu
65                  70                  75                  80
Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg
                85                  90                  95
Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu
            100                 105                 110
Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala
        115                 120                 125
Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu
    130                 135                 140
Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys
145                 150                 155                 160
Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro
                165                 170                 175
Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn
            180                 185                 190
Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser
        195                 200                 205
Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys
    210                 215                 220
Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser
225                 230                 235                 240
Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg
                245                 250                 255
Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu
            260                 265                 270
Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His
        275                 280                 285
Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys
    290                 295                 300
Ser Ser
305

<210> 970
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 970
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Asp Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Pro Tyr Leu Cys Ser Val Cys Arg
            740                 745                 750
Pro Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu Gln Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Val Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Asp Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 971
<211> 652
<212> PRT
<213> Homo sapiens

<400> 971
Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser
 1               5                  10                  15
Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His
            20                  25                  30
Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys
        35                  40                  45
Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe
    50                  55                  60
Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile
65                  70                  75                  80
Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110
Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125
Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp
    130                 135                 140
Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn
145                 150                 155                 160
Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp
                165                 170                 175
Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val
            180                 185                 190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe
        195                 200                 205
Ala Ala Tyr His Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp
    210                 215                 220
Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe
225                 230                 235                 240
Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255
Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser
            260                 265                 270
Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys
        275                 280                 285
Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn
    290                 295                 300
Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp
305                 310                 315                 320
Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys
                325                 330                 335
Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr
            340                 345                 350
Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile
        355                 360                 365
Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn
    370                 375                 380
Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr
385                 390                 395                 400
Phe His Pro Ser Val His Pro Met Ser Thr Ala Ser Gln Val Ala Ser
                405                 410                 415
Thr Trp Gly Asp Pro Phe Ser Ala Thr Val Asp Ala Val Asp Asp Ala
            420                 425                 430
Ile Pro Ser Leu Asn Pro Phe Leu Thr Lys Ser Ser Gly Asp Val His
        435                 440                 445
Leu Ser Ile Ser Ser Asp Val Ser Thr Phe Thr Thr Arg Thr Pro Thr
    450                 455                 460
His Glu Met Phe Val Gly Phe Thr Pro Ser Pro Val Ala Gln Pro His
465                 470                 475                 480
Pro Ser Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys
                485                 490                 495
Ser Thr Asn Val Ile Val Asp Ser Gly Gly Phe Asp Glu Leu Gly Gly
            500                 505                 510
Leu Leu Lys Pro Thr Val Ala Ser Gln Asn Gln Asn Leu Pro Val Ala
        515                 520                 525
Lys Leu Pro Pro Ser Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu
    530                 535                 540
Ala Asn Leu Val Gly Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn
545                 550                 555                 560
Asp Val Asn Trp Ser Gln Pro Gly Glu Lys Lys Leu Thr Gly Gly Ser
                565                 570                 575
Asn Cys Glu Pro Lys Val Ala Pro Thr Thr Ala Trp Asn Ala Ala Thr
            580                 585                 590
Met Ala Pro Pro Val Met Ala Tyr Pro Ala Thr Thr Pro Thr Gly Met
        595                 600                 605
Ile Gly Tyr Gly Ile Pro Pro Gln Met Gly Ser Val Pro Val Met Thr
    610                 615                 620
Gln Pro Thr Leu Ile Tyr Ser Gln Pro Val Met Arg Pro Pro Asn Pro
625                 630                 635                 640
Phe Gly Pro Val Ser Gly Ala Gln Ile Gln Phe Met
                645                 650

<210> 972
<211> 907
<212> PRT
<213> Homo sapiens

<400> 972
Met Ser Gly Gln Thr Leu Thr Asp Arg Ile Ala Ala Ala Gln Tyr Ser
 1               5                  10                  15
Val Thr Gly Ser Ala Val Ala Arg Ala Val Cys Lys Ala Thr Thr His
            20                  25                  30
Glu Val Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Ala
        35                  40                  45
Thr Asn Glu Thr Asn Val Asn Ile Pro Gln Met Ala Asp Thr Leu Phe
    50                  55                  60
Glu Arg Ala Thr Asn Ser Ser Trp Val Val Val Phe Lys Ala Leu Val
65                  70                  75                  80
Thr Thr His His Leu Met Val His Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110
Ser Gly Ser His Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125
Arg Tyr Leu Asn Glu Lys Ala Phe Ser Tyr Arg Gln Met Ala Phe Asp
    130                 135                 140
Phe Ala Arg Val Lys Lys Gly Ala Asp Gly Val Met Arg Thr Met Ala
145                 150                 155                 160
Pro Glu Lys Leu Leu Lys Ser Met Pro Ile Leu Gln Gly Gln Ile Asp
                165                 170                 175
Ala Leu Leu Glu Phe Asp Val His Pro Asn Glu Leu Thr Asn Gly Val
            180                 185                 190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Leu Ile Lys Leu Phe
        195                 200                 205
Ala Cys Tyr Asn Asp Gly Val Ile Asn Leu Leu Glu Lys Phe Phe Glu
    210                 215                 220
Met Lys Lys Gly Gln Cys Lys Asp Ala Leu Glu Ile Tyr Lys Arg Phe
225                 230                 235                 240
Leu Thr Arg Met Thr Arg Val Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255
Val Gly Ile Asp Lys Gly Asp Ile Pro Asp Leu Thr Gln Ala Pro Ser
            260                 265                 270
Ser Leu Met Glu Thr Leu Glu Gln His Leu Asn Thr Leu Glu Gly Lys
        275                 280                 285
Lys Pro Gly Asn Asn Glu Gly Ser Gly Ala Pro Ser Pro Leu Ser Lys
    290                 295                 300
Ser Ser Pro Ala Thr Thr Val Thr Ser Pro Asn Ser Thr Pro Ala Lys
305                 310                 315                 320
Thr Ile Asp Thr Ser Pro Pro Val Asp Leu Phe Ala Thr Ala Ser Ala
                325                 330                 335
Ala Val Pro Val Ser Thr Ser Lys Pro Ser Ser Asp Leu Leu Asp Leu
            340                 345                 350
Gln Pro Asp Phe Ser Ser Gly Gly Ala Ala Ala Ala Ala Ala Pro Ala
        355                 360                 365
Pro Pro Pro Pro Ala Gly Gly Ala Thr Ala Trp Gly Asp Leu Leu Gly
    370                 375                 380
Glu Asp Ser Leu Ala Ala Leu Ser Ser Val Pro Ser Glu Ala Gln Ile
385                 390                 395                 400
Ser Asp Pro Phe Ala Pro Glu Pro Thr Pro Pro Thr Thr Thr Ala Glu
                405                 410                 415
Ile Ala Thr Ala Ser Ala Ser Ala Ser Thr Thr Thr Thr Val Thr Ala
            420                 425                 430
Val Thr Ala Glu Val Asp Leu Phe Gly Asp Ala Phe Ala Ala Ser Pro
        435                 440                 445
Gly Glu Ala Pro Ala Ala Ser Glu Gly Ala Ala Ala Pro Ala Thr Pro
    450                 455                 460
Thr Pro Val Ala Ala Ala Leu Asp Ala Cys Ser Gly Asn Asp Pro Phe
465                 470                 475                 480
Ala Pro Ser Glu Gly Ser Ala Glu Ala Ala Pro Glu Leu Asp Leu Phe
                485                 490                 495
Ala Met Lys Pro Pro Glu Thr Ser Val Pro Val Val Thr Pro Thr Ala
            500                 505                 510
Ser Thr Ala Pro Pro Val Pro Ala Thr Ala Pro Ser Pro Ala Pro Ala
        515                 520                 525
Val Ala Ala Ala Ala Ala Ala Thr Thr Ala Ala Thr Ala Ala Ala Thr
    530                 535                 540
Thr Thr Thr Thr Thr Ser Ala Ala Thr Ala Thr Thr Ala Pro Pro Ala
545                 550                 555                 560
Leu Asp Ile Phe Gly Asp Leu Phe Glu Ser Thr Pro Glu Val Ala Ala
                565                 570                 575
Ala Pro Lys Pro Asp Ala Ala Pro Ser Ile Asp Leu Phe Ser Thr Asp
            580                 585                 590
Ala Phe Ser Ser Pro Pro Gln Gly Ala Ser Pro Val Pro Glu Ser Ser
        595                 600                 605
Leu Thr Ala Asp Leu Leu Ser Val Asp Ala Phe Ala Ala Pro Ser Pro
    610                 615                 620
Ala Thr Thr Ala Ser Pro Ala Lys Val Asp Ser Ser Gly Val Ile Asp
625                 630                 635                 640
Leu Phe Gly Asp Ala Phe Gly Ser Ser Ala Ser Glu Pro Gln Pro Ala
                645                 650                 655
Ser Gln Ala Ala Ser Ser Ser Ser Ala Ser Ala Asp Leu Leu Ala Gly
            660                 665                 670
Phe Gly Gly Ser Phe Met Ala Pro Ser Pro Ser Pro Val Thr Pro Ala
        675                 680                 685
Gln Asn Asn Leu Leu Gln Pro Asn Phe Glu Ala Ala Phe Gly Thr Thr
    690                 695                 700
Pro Ser Thr Ser Ser Ser Ser Ser Phe Asp Pro Ser Val Phe Asp Gly
705                 710                 715                 720
Leu Gly Asp Leu Leu Met Pro Thr Met Ala Pro Ala Gly Gln Pro Ala
                725                 730                 735
Pro Val Ser Met Val Pro Pro Ser Pro Ala Met Ala Ala Ser Lys Ala
            740                 745                 750
Leu Gly Ser Asp Leu Asp Ser Ser Leu Ala Ser Leu Val Gly Asn Leu
        755                 760                 765
Gly Ile Ser Gly Thr Thr Thr Lys Lys Gly Asp Leu Gln Trp Asn Ala
    770                 775                 780
Gly Glu Lys Lys Leu Thr Gly Gly Ala Asn Trp Gln Pro Lys Val Ala
785                 790                 795                 800
Pro Ala Thr Trp Ser Ala Gly Val Pro Pro Ser Ala Pro Leu Gln Gly
                805                 810                 815
Ala Val Pro Pro Thr Ser Ser Val Pro Pro Val Ala Gly Ala Pro Ser
            820                 825                 830
Val Gly Gln Pro Gly Ala Gly Phe Gly Met Pro Pro Ala Gly Thr Gly
        835                 840                 845
Met Pro Met Met Pro Gln Gln Pro Val Met Phe Ala Gln Pro Met Met
    850                 855                 860
Arg Pro Pro Phe Gly Ala Ala Ala Val Pro Gly Thr Gln Leu Ser Pro
865                 870                 875                 880
Ser Pro Thr Pro Ala Ser Gln Ser Pro Lys Lys Pro Pro Ala Lys Asp
                885                 890                 895
Pro Leu Ala Asp Leu Asn Ile Lys Asp Phe Leu
            900                 905

<210> 973
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 973
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15
Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735
Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn
            740                 745                 750
Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880
Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu
                885                 890                 895
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Leu Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135
Pro Glu Leu Ala Thr Pro Ala Ile Arg Arg Ile Met Leu Asn Cys Trp
            1140                1145                1150
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295
Phe Arg


<210> 974
<211> 907
<212> PRT
<213> Homo sapiens

<400> 974
Met Ser Gly Gln Thr Leu Thr Asp Arg Ile Ala Ala Ala Gln Tyr Ser
 1               5                  10                  15
Val Thr Gly Ser Ala Val Ala Arg Ala Val Cys Lys Ala Thr Thr His
            20                  25                  30
Glu Val Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Ala
        35                  40                  45
Thr Asn Glu Thr Asn Val Asn Ile Pro Gln Met Ala Asp Thr Leu Phe
    50                  55                  60
Glu Arg Ala Thr Asn Ser Ser Trp Val Val Val Phe Lys Ala Leu Val
65                  70                  75                  80
Thr Thr His His Leu Met Val His Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110
Ser Gly Ser His Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125
Arg Tyr Leu Asn Glu Lys Ala Phe Ser Tyr Arg Gln Met Ala Phe Asp
    130                 135                 140
Phe Ala Arg Val Lys Lys Gly Ala Asp Gly Val Met Arg Thr Met Ala
145                 150                 155                 160
Pro Glu Lys Leu Leu Lys Ser Met Pro Ile Leu Gln Gly Gln Ile Asp
                165                 170                 175
Ala Leu Leu Glu Phe Asp Val His Pro Asn Glu Leu Thr Asn Gly Val
            180                 185                 190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Leu Ile Lys Leu Phe
        195                 200                 205
Ala Cys Tyr Asn Asp Gly Val Ile Asn Leu Leu Glu Lys Phe Phe Glu
    210                 215                 220
Met Lys Lys Gly Gln Cys Lys Asp Ala Leu Glu Ile Tyr Lys Arg Phe
225                 230                 235                 240
Leu Thr Arg Met Thr Arg Val Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255
Val Gly Ile Asp Lys Gly Asp Ile Pro Asp Leu Thr Gln Ala Pro Ser
            260                 265                 270
Ser Leu Met Glu Thr Leu Glu Gln His Leu Asn Thr Leu Glu Gly Lys
        275                 280                 285
Lys Pro Gly Asn Asn Glu Gly Ser Gly Ala Pro Ser Pro Leu Ser Lys
    290                 295                 300
Ser Ser Pro Ala Thr Thr Val Thr Ser Pro Asn Ser Thr Pro Ala Lys
305                 310                 315                 320
Thr Ile Asp Thr Ser Pro Pro Val Asp Leu Phe Ala Thr Ala Ser Ala
                325                 330                 335
Ala Val Pro Val Ser Thr Ser Lys Pro Ser Ser Asp Leu Leu Asp Leu
            340                 345                 350
Gln Pro Asp Phe Ser Ser Gly Gly Ala Ala Ala Ala Ala Ala Pro Ala
        355                 360                 365
Pro Pro Pro Pro Ala Gly Gly Ala Thr Ala Trp Gly Asp Leu Leu Gly
    370                 375                 380
Glu Asp Ser Leu Ala Ala Leu Ser Ser Val Pro Ser Glu Ala Gln Ile
385                 390                 395                 400
Ser Asp Pro Phe Ala Pro Glu Pro Thr Pro Pro Thr Thr Thr Ala Glu
                405                 410                 415
Ile Ala Thr Ala Ser Ala Ser Ala Ser Thr Thr Thr Thr Val Thr Ala
            420                 425                 430
Val Thr Ala Glu Val Asp Leu Phe Gly Asp Ala Phe Ala Ala Ser Pro
        435                 440                 445
Gly Glu Ala Pro Ala Ala Ser Glu Gly Ala Ala Ala Pro Ala Thr Pro
    450                 455                 460
Thr Pro Val Ala Ala Ala Leu Asp Ala Cys Ser Gly Asn Asp Pro Phe
465                 470                 475                 480
Ala Pro Ser Glu Gly Ser Ala Glu Ala Ala Pro Glu Leu Asp Leu Phe
                485                 490                 495
Ala Met Lys Pro Pro Glu Thr Ser Val Pro Val Val Thr Pro Thr Ala
            500                 505                 510
Ser Thr Ala Pro Pro Val Pro Ala Thr Ala Pro Ser Pro Ala Pro Ala
        515                 520                 525
Val Ala Ala Ala Ala Ala Ala Thr Thr Ala Ala Thr Ala Ala Ala Thr
    530                 535                 540
Thr Thr Thr Thr Thr Ser Ala Ala Thr Ala Thr Thr Ala Pro Pro Ala
545                 550                 555                 560
Leu Asp Ile Phe Gly Asp Leu Phe Glu Ser Thr Pro Glu Val Ala Ala
                565                 570                 575
Ala Pro Lys Pro Asp Ala Ala Pro Ser Ile Asp Leu Phe Ser Thr Asp
            580                 585                 590
Ala Phe Ser Ser Pro Pro Gln Gly Ala Ser Pro Val Pro Glu Ser Ser
        595                 600                 605
Leu Thr Ala Asp Leu Leu Ser Val Asp Ala Phe Ala Ala Pro Ser Pro
    610                 615                 620
Ala Thr Thr Ala Ser Pro Ala Lys Val Asp Ser Ser Gly Val Ile Asp
625                 630                 635                 640
Leu Phe Gly Asp Ala Phe Gly Ser Ser Ala Ser Glu Pro Gln Pro Ala
                645                 650                 655
Ser Gln Ala Ala Ser Ser Ser Ser Ala Ser Ala Asp Leu Leu Ala Gly
            660                 665                 670
Phe Gly Gly Ser Phe Met Ala Pro Ser Pro Ser Pro Val Thr Pro Ala
        675                 680                 685
Gln Asn Asn Leu Leu Gln Pro Asn Phe Glu Ala Ala Phe Gly Thr Thr
    690                 695                 700
Pro Ser Thr Ser Ser Ser Ser Ser Phe Asp Pro Ser Val Phe Asp Gly
705                 710                 715                 720
Leu Gly Asp Leu Leu Met Pro Thr Met Ala Pro Ala Gly Gln Pro Ala
                725                 730                 735
Pro Val Ser Met Val Pro Pro Ser Pro Ala Met Ala Ala Ser Lys Ala
            740                 745                 750
Leu Gly Ser Asp Leu Asp Ser Ser Leu Ala Ser Leu Val Gly Asn Leu
        755                 760                 765
Gly Ile Ser Gly Thr Thr Thr Lys Lys Gly Asp Leu Gln Trp Asn Ala
    770                 775                 780
Gly Glu Lys Lys Leu Thr Gly Gly Ala Asn Trp Gln Pro Lys Val Ala
785                 790                 795                 800
Pro Ala Thr Trp Ser Ala Gly Val Pro Pro Ser Ala Pro Leu Gln Gly
                805                 810                 815
Ala Val Pro Pro Thr Ser Ser Val Pro Pro Val Ala Gly Ala Pro Ser
            820                 825                 830
Val Gly Gln Pro Gly Ala Gly Phe Gly Met Pro Pro Ala Gly Thr Gly
        835                 840                 845
Met Pro Met Met Pro Gln Gln Pro Val Met Phe Ala Gln Pro Met Met
    850                 855                 860
Arg Pro Pro Phe Gly Ala Ala Ala Val Pro Gly Thr Gln Leu Ser Pro
865                 870                 875                 880
Ser Pro Thr Pro Ala Ser Gln Ser Pro Lys Lys Pro Pro Ala Lys Asp
                885                 890                 895
Pro Leu Ala Asp Leu Asn Ile Lys Asp Phe Leu
            900                 905

<210> 975
<211> 652
<212> PRT
<213> Homo sapiens

<400> 975
Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser
 1               5                  10                  15
Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His
            20                  25                  30
Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys
        35                  40                  45
Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe
    50                  55                  60
Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile
65                  70                  75                  80
Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110
Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125
Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp
    130                 135                 140
Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn
145                 150                 155                 160
Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp
                165                 170                 175
Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val
            180                 185                 190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe
        195                 200                 205
Ala Ala Tyr His Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp
    210                 215                 220
Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe
225                 230                 235                 240
Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255
Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser
            260                 265                 270
Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys
        275                 280                 285
Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn
    290                 295                 300
Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp
305                 310                 315                 320
Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys
                325                 330                 335
Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr
            340                 345                 350
Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile
        355                 360                 365
Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn
    370                 375                 380
Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr
385                 390                 395                 400
Phe His Pro Ser Val His Pro Met Ser Thr Ala Ser Gln Val Ala Ser
                405                 410                 415
Thr Trp Gly Asp Pro Phe Ser Ala Thr Val Asp Ala Val Asp Asp Ala
            420                 425                 430
Ile Pro Ser Leu Asn Pro Phe Leu Thr Lys Ser Ser Gly Asp Val His
        435                 440                 445
Leu Ser Ile Ser Ser Asp Val Ser Thr Phe Thr Thr Arg Thr Pro Thr
    450                 455                 460
His Glu Met Phe Val Gly Phe Thr Pro Ser Pro Val Ala Gln Pro His
465                 470                 475                 480
Pro Ser Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys
                485                 490                 495
Ser Thr Asn Val Ile Val Asp Ser Gly Gly Phe Asp Glu Leu Gly Gly
            500                 505                 510
Leu Leu Lys Pro Thr Val Ala Ser Gln Asn Gln Asn Leu Pro Val Ala
        515                 520                 525
Lys Leu Pro Pro Ser Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu
    530                 535                 540
Ala Asn Leu Val Gly Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn
545                 550                 555                 560
Asp Val Asn Trp Ser Gln Pro Gly Glu Lys Lys Leu Thr Gly Gly Ser
                565                 570                 575
Asn Cys Glu Pro Lys Val Ala Pro Thr Thr Ala Trp Asn Ala Ala Thr
            580                 585                 590
Met Ala Pro Pro Val Met Ala Tyr Pro Ala Thr Thr Pro Thr Gly Met
        595                 600                 605
Ile Gly Tyr Gly Ile Pro Pro Gln Met Gly Ser Val Pro Val Met Thr
    610                 615                 620
Gln Pro Thr Leu Ile Tyr Ser Gln Pro Val Met Arg Pro Pro Asn Pro
625                 630                 635                 640
Phe Gly Pro Val Ser Gly Ala Gln Ile Gln Phe Met
                645                 650

<210> 976
<211> 902
<212> PRT
<213> Homo sapiens

<400> 976
Met Ser Gly Gln Thr Leu Thr Asp Arg Ile Ala Ala Ala Gln Tyr Ser
 1               5                  10                  15
Val Thr Gly Ser Ala Val Ala Arg Ala Val Cys Lys Ala Thr Thr His
            20                  25                  30
Glu Val Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Ala
        35                  40                  45
Thr Asn Glu Thr Asn Val Asn Ile Pro Gln Met Ala Asp Thr Leu Phe
    50                  55                  60
Glu Arg Ala Thr Asn Ser Ser Trp Val Val Val Phe Lys Ala Leu Val
65                  70                  75                  80
Thr Thr His His Leu Met Val His Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110
Ser Gly Ser His Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125
Arg Tyr Leu Asn Glu Lys Ala Phe Ser Tyr Arg Gln Met Ala Phe Asp
    130                 135                 140
Phe Ala Arg Val Lys Lys Gly Ala Asp Gly Val Met Arg Thr Met Ala
145                 150                 155                 160
Pro Glu Lys Leu Leu Lys Ser Met Pro Ile Leu Gln Gly Gln Ile Asp
                165                 170                 175
Ala Leu Leu Glu Phe Asp Val His Pro Asn Glu Leu Thr Asn Gly Val
            180                 185                 190
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Leu Ile Lys Leu Phe
        195                 200                 205
Ala Cys Tyr Asn Asp Gly Val Ile Asn Leu Leu Glu Lys Phe Phe Glu
    210                 215                 220
Met Lys Lys Gly Gln Cys Lys Asp Ala Leu Glu Ile Tyr Lys Arg Phe
225                 230                 235                 240
Leu Thr Arg Met Thr Arg Val Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255
Val Gly Ile Asp Lys Gly Asp Ile Pro Asp Leu Thr Gln Ala Pro Ser
            260                 265                 270
Ser Leu Met Glu Thr Leu Glu Gln His Leu Asn Thr Leu Glu Gly Lys
        275                 280                 285
Lys Pro Gly Asn Lys Tyr Ala Ser Gly Ala Pro Ser Pro Leu Ser Lys
    290                 295                 300
Ser Ser Pro Ala Thr Thr Val Thr Ser Pro Asn Ser Thr Pro Ala Lys
305                 310                 315                 320
Thr Ile Asp Thr Ser Pro Pro Val Asp Leu Phe Ala Thr Ala Ser Ala
                325                 330                 335
Ala Val Pro Val Ser Thr Ser Lys Pro Ser Ser Asp Leu Leu Asp Leu
            340                 345                 350
Gln Pro Asp Phe Ser Ser Gly Gly Ala Ala Ala Ala Ala Ala Pro Ala
        355                 360                 365
Pro Pro Pro Pro Ala Gly Gly Ala Thr Ala Trp Gly Asp Ser Leu Ala
    370                 375                 380
Ala Leu Ser Ser Val Pro Ser Glu Ala Gln Ile Ser Asp Pro Phe Ala
385                 390                 395                 400
Pro Glu Pro Thr Pro Pro Thr Thr Thr Ala Glu Ile Ala Thr Ala Ser
                405                 410                 415
Ala Ser Ala Ser Thr Thr Thr Thr Val Thr Ala Val Thr Ala Glu Val
            420                 425                 430
Asp Leu Phe Gly Asp Ala Phe Ala Ala Ser Pro Gly Glu Ala Pro Ala
        435                 440                 445
Ala Ser Glu Gly Ala Ala Ala Pro Ala Thr Pro Thr Pro Val Ala Ala
    450                 455                 460
Ala Leu Asp Ala Cys Ser Gly Asn Asp Pro Phe Ala Pro Ser Glu Gly
465                 470                 475                 480
Ser Ala Glu Ala Ala Pro Glu Leu Asp Leu Phe Ala Met Lys Pro Pro
                485                 490                 495
Glu Thr Ser Val Pro Val Val Thr Pro Thr Ala Ser Thr Ala Pro Pro
            500                 505                 510
Val Pro Ala Thr Ala Pro Ser Pro Ala Pro Ala Val Ala Ala Ala Ala
        515                 520                 525
Ala Ala Thr Thr Ala Ala Thr Ala Ala Ala Thr Thr Thr Thr Thr Thr
    530                 535                 540
Ser Ala Ala Thr Ala Thr Thr Ala Pro Pro Ala Leu Asp Ile Phe Gly
545                 550                 555                 560
Asp Leu Phe Glu Ser Thr Pro Glu Val Ala Ala Ala Pro Lys Pro Asp
                565                 570                 575
Ala Ala Pro Ser Ile Asp Leu Phe Ser Thr Asp Ala Phe Ser Ser Pro
            580                 585                 590
Pro Gln Gly Ala Ser Pro Val Pro Glu Ser Ser Leu Thr Ala Asp Leu
        595                 600                 605
Leu Ser Val Asp Ala Phe Ala Ala Pro Ser Pro Ala Thr Thr Ala Ser
    610                 615                 620
Pro Ala Lys Val Asp Ser Ser Gly Val Ile Asp Leu Phe Gly Asp Ala
625                 630                 635                 640
Phe Gly Ser Ser Ala Ser Glu Pro Gln Pro Ala Ser Gln Ala Ala Ser
                645                 650                 655
Ser Ser Ser Ala Ser Ala Asp Leu Leu Ala Gly Phe Gly Gly Ser Phe
            660                 665                 670
Met Ala Pro Ser Pro Ser Pro Val Thr Pro Ala Gln Asn Asn Leu Leu
        675                 680                 685
Gln Pro Asn Phe Glu Ala Ala Phe Gly Thr Thr Pro Ser Thr Ser Ser
    690                 695                 700
Ser Ser Ser Phe Asp Pro Ser Val Phe Asp Gly Leu Gly Asp Leu Leu
705                 710                 715                 720
Met Pro Thr Met Ala Pro Ala Gly Gln Pro Ala Pro Val Ser Met Val
                725                 730                 735
Pro Pro Ser Pro Ala Met Ala Ala Ser Lys Ala Leu Gly Ser Asp Leu
            740                 745                 750
Asp Ser Ser Leu Ala Ser Leu Val Gly Asn Leu Gly Ile Ser Gly Thr
        755                 760                 765
Thr Thr Lys Lys Gly Asp Leu Gln Trp Asn Ala Gly Glu Lys Lys Leu
    770                 775                 780
Thr Gly Gly Ala Asn Trp Gln Pro Lys Val Ala Pro Ala Thr Trp Ser
785                 790                 795                 800
Ala Gly Val Pro Pro Ser Ala Pro Leu Gln Gly Ala Val Pro Pro Thr
                805                 810                 815
Ser Ser Val Pro Pro Val Ala Gly Ala Pro Ser Val Gly Gln Pro Gly
            820                 825                 830
Ala Gly Phe Gly Met Pro Pro Ala Gly Thr Gly Met Pro Met Met Pro
        835                 840                 845
Gln Gln Pro Val Met Phe Ala Gln Pro Met Met Arg Pro Pro Phe Gly
    850                 855                 860
Ala Ala Ala Val Pro Gly Thr Gln Leu Ser Pro Ser Pro Thr Pro Ala
865                 870                 875                 880
Ser Gln Ser Pro Lys Lys Pro Pro Ala Lys Asp Pro Leu Ala Asp Leu
                885                 890                 895
Asn Ile Lys Asp Phe Leu
            900

<210> 977
<211> 306
<212> PRT
<213> Homo sapiens

<400> 977
Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala
 1               5                  10                  15
Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp
            20                  25                  30
Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly
        35                  40                  45
Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr
    50                  55                  60
Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu
65                  70                  75                  80
Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg
                85                  90                  95
Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu
            100                 105                 110
Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala
        115                 120                 125
Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu
    130                 135                 140
Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys
145                 150                 155                 160
Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro
                165                 170                 175
Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn
            180                 185                 190
Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser
        195                 200                 205
Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys
    210                 215                 220
Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser
225                 230                 235                 240
Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg
                245                 250                 255
Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu
            260                 265                 270
Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His
        275                 280                 285
Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys
    290                 295                 300
Ser Ser
305

<210> 978
<211> 2338
<212> PRT
<213> Homo sapiens

<400> 978
Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn
 1               5                  10                  15
Pro Leu Ile Lys Leu Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro
            20                  25                  30
Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg
        35                  40                  45
Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys
    50                  55                  60
Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly
65                  70                  75                  80
Leu Lys Leu Val Arg Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu
                85                  90                  95
Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr
            100                 105                 110
Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys
        115                 120                 125
Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu
    130                 135                 140
Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser
145                 150                 155                 160
Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser
                165                 170                 175
Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu
            180                 185                 190
Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala
        195                 200                 205
Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala
    210                 215                 220
Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr
225                 230                 235                 240
Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met
                245                 250                 255
Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys
            260                 265                 270
Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr
        275                 280                 285
Trp Asp Thr Glu Tyr Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys
    290                 295                 300
Gly Ala Thr Asp Gly Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg
305                 310                 315                 320
His Ala Glu Pro Glu Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr
                325                 330                 335
Glu Thr Glu Lys Lys His Phe Phe Ile Asn Ile Cys His Arg Val Leu
            340                 345                 350
Gln Glu Gly Lys Ala Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala
        355                 360                 365
Val Asp Lys Asn Gly Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro
    370                 375                 380
Met Lys Glu Lys Gly Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp
385                 390                 395                 400
Cys Gly His Gly Lys Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys
                405                 410                 415
Pro Gly Asp Leu Glu Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly
            420                 425                 430
Gly Cys Phe Tyr Glu Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu
        435                 440                 445
Ser Lys Thr Glu Gly Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly
    450                 455                 460
Phe Ser Phe Asp Leu Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys
465                 470                 475                 480
Val Glu Thr Lys Lys Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val
                485                 490                 495
Ser Val Ser Pro Cys Gln Pro Asp Ser Gly Ala Cys Gln Cys Gly Ser
            500                 505                 510
Leu Gly Val Leu Leu Pro Leu Arg Ser Leu Leu Arg Glu Thr Cys Val
        515                 520                 525
Tyr Phe Ser Asp Glu Lys Thr Trp Asn Leu Gly Leu Ser Asn Ala Lys
    530                 535                 540
Leu Ser Tyr Tyr Asp Gly Met Ile Gln Leu Asn Tyr Arg Gly Gly Thr
545                 550                 555                 560
Pro Tyr Asn Asn Glu Arg His Thr Pro Arg Ala Thr Leu Ile Thr Phe
                565                 570                 575
Leu Cys Asp Arg Asp Ala Gly Val Gly Phe Pro Glu Tyr Gln Glu Glu
            580                 585                 590
Asp Asn Ser Thr Tyr Asn Phe Arg Trp Tyr Thr Ser Tyr Ala Cys Pro
        595                 600                 605
Glu Glu Pro Leu Glu Cys Val Val Thr Asp Pro Ser Thr Leu Glu Gln
    610                 615                 620
Tyr Asp Leu Ser Ser Leu Ala Lys Ser Glu Gly Gly Leu Gly Gly Asn
625                 630                 635                 640
Trp Tyr Ala Met Asp Asn Ser Gly Glu His Val Thr Trp Arg Lys Tyr
                645                 650                 655
Tyr Ile Asn Val Cys Arg Pro Leu Asn Pro Val Pro Gly Cys Asn Arg
            660                 665                 670
Tyr Ala Ser Ala Cys Gln Met Lys Tyr Glu Lys Asp Gln Gly Ser Phe
        675                 680                 685
Thr Glu Val Val Ser Ile Ser Asn Leu Gly Met Ala Lys Thr Gly Pro
    690                 695                 700
Val Val Glu Asp Ser Gly Ser Leu Leu Leu Glu Tyr Val Asn Gly Ser
705                 710                 715                 720
Ala Cys Thr Thr Ser Asp Gly Arg Gln Thr Thr Tyr Thr Thr Arg Ile
                725                 730                 735
His Leu Val Cys Ser Arg Gly Arg Leu Asn Ser His Pro Ile Phe Ser
            740                 745                 750
Leu Asn Trp Glu Cys Val Val Ser Phe Leu Trp Asn Thr Glu Ala Ala
        755                 760                 765
Cys Pro Ile Gln Thr Thr Thr Asp Thr Asp Gln Ala Cys Ser Ile Arg
    770                 775                 780
Asp Pro Asn Ser Gly Phe Val Phe Asn Leu Asn Pro Leu Asn Ser Ser
785                 790                 795                 800
Gln Gly Tyr Asn Val Ser Gly Ile Gly Lys Ile Phe Met Phe Asn Val
                805                 810                 815
Cys Gly Thr Met Pro Val Cys Gly Thr Ile Leu Gly Lys Pro Ala Ser
            820                 825                 830
Gly Cys Glu Ala Glu Thr Gln Thr Glu Glu Leu Lys Asn Trp Lys Pro
        835                 840                 845
Ala Arg Pro Val Gly Ile Glu Lys Ser Leu Gln Leu Ser Thr Glu Gly
    850                 855                 860
Phe Ile Thr Leu Thr Tyr Lys Gly Pro Leu Ser Ala Lys Gly Thr Ala
865                 870                 875                 880
Asp Ala Phe Ile Val Arg Phe Val Cys Asn Asp Asp Val Tyr Ser Gly
                885                 890                 895
Pro Leu Lys Phe Leu His Gln Asp Ile Asp Ser Gly Gln Gly Ile Arg
            900                 905                 910
Asn Thr Tyr Phe Glu Phe Glu Thr Ala Leu Ala Cys Val Pro Ser Pro
        915                 920                 925
Val Asp Cys Gln Val Thr Asp Leu Ala Gly Asn Glu Tyr Asp Leu Thr
    930                 935                 940
Gly Leu Ser Thr Val Arg Lys Pro Trp Thr Ala Val Asp Thr Ser Val
945                 950                 955                 960
Asp Gly Arg Lys Arg Thr Phe Tyr Leu Ser Val Cys Asn Pro Leu Pro
                965                 970                 975
Tyr Ile Pro Gly Cys Gln Gly Ser Ala Val Gly Ser Cys Leu Val Ser
            980                 985                 990
Glu Gly Asn Ser Trp Asn Leu Gly Val Val Gln Met Ser Pro Gln Ala
        995                 1000                1005
Ala Ala Asn Gly Ser Leu Ser Ile Met Tyr Val Asn Gly Asp Lys Cys
    1010                1015                1020
Gly Asn Gln Arg Phe Ser Thr Arg Ile Thr Phe Glu Cys Ala Gln Ile
1025                1030                1035                1040
Ser Gly Ser Pro Ala Phe Gln Leu Gln Asp Gly Cys Glu Tyr Val Phe
                1045                1050                1055
Ile Trp Arg Thr Val Glu Ala Cys Pro Val Val Arg Val Glu Gly Asp
            1060                1065                1070
Asn Cys Glu Val Lys Asp Pro Arg His Gly Asn Leu Tyr Asp Leu Lys
        1075                1080                1085
Pro Leu Gly Leu Asn Asp Thr Ile Val Ser Ala Gly Glu Tyr Thr Tyr
    1090                1095                1100
Tyr Phe Arg Val Cys Gly Lys Leu Ser Ser Asp Val Cys Pro Thr Ser
1105                1110                1115                1120
Asp Lys Ser Lys Val Val Ser Ser Cys Gln Glu Lys Arg Glu Pro Gln
                1125                1130                1135
Gly Phe His Lys Val Ala Gly Leu Leu Thr Gln Lys Leu Thr Tyr Glu
            1140                1145                1150
Asn Gly Leu Leu Lys Met Asn Phe Thr Gly Gly Asp Thr Cys His Lys
        1155                1160                1165
Val Tyr Gln Arg Ser Thr Ala Ile Phe Phe Tyr Cys Asp Arg Gly Thr
    1170                1175                1180
Gln Arg Pro Val Phe Leu Lys Glu Thr Ser Asp Cys Ser Tyr Leu Phe
1185                1190                1195                1200
Glu Trp Arg Thr Gln Tyr Ala Cys Pro Pro Phe Asp Leu Thr Glu Cys
                1205                1210                1215
Ser Phe Lys Asp Gly Ala Gly Asn Ser Phe Asp Leu Ser Ser Leu Ser
            1220                1225                1230
Arg Tyr Ser Asp Asn Trp Glu Ala Ile Thr Gly Thr Gly Asp Pro Glu
        1235                1240                1245
His Tyr Leu Ile Asn Val Cys Lys Ser Leu Ala Pro Gln Ala Gly Thr
    1250                1255                1260
Glu Pro Cys Pro Pro Glu Ala Ala Ala Cys Leu Leu Gly Gly Ser Lys
1265                1270                1275                1280
Pro Val Asn Leu Gly Arg Val Arg Asp Gly Pro Gln Trp Arg Asp Gly
                1285                1290                1295
Ile Ile Val Leu Lys Tyr Val Asp Gly Asp Leu Cys Pro Asp Gly Ile
            1300                1305                1310
Arg Lys Lys Ser Thr Thr Ile Arg Phe Thr Cys Ser Glu Ser Gln Val
        1315                1320                1325
Asn Ser Arg Pro Met Phe Ile Ser Ala Val Glu Asp Cys Glu Tyr Thr
    1330                1335                1340
Phe Ala Trp Pro Thr Ala Thr Ala Cys Pro Met Lys Ser Asn Glu His
1345                1350                1355                1360
Asp Asp Cys Gln Val Thr Asn Pro Ser Thr Gly His Leu Phe Asp Leu
                1365                1370                1375
Ser Ser Leu Ser Gly Arg Ala Gly Phe Thr Ala Ala Tyr Ser Glu Lys
            1380                1385                1390
Gly Leu Val Tyr Met Ser Ile Cys Gly Glu Asn Glu Asn Cys Pro Pro
        1395                1400                1405
Gly Val Gly Ala Cys Phe Gly Gln Thr Arg Ile Ser Val Gly Lys Ala
    1410                1415                1420
Asn Lys Arg Leu Arg Tyr Val Asp Gln Val Leu Gln Leu Val Tyr Lys
1425                1430                1435                1440
Asp Gly Ser Pro Cys Pro Ser Lys Ser Gly Leu Ser Tyr Lys Ser Val
                1445                1450                1455
Ile Ser Phe Val Cys Arg Pro Glu Ala Arg Pro Thr Asn Arg Pro Met
            1460                1465                1470
Leu Ile Ser Leu Asp Lys Gln Thr Cys Thr Leu Phe Phe Ser Trp His
        1475                1480                1485
Thr Pro Leu Ala Cys Glu Gln Ala Thr Glu Cys Ser Val Arg Asn Gly
    1490                1495                1500
Ser Ser Ile Val Asp Leu Ser Pro Leu Ile His Arg Thr Gly Gly Tyr
1505                1510                1515                1520
Glu Ala Tyr Asp Glu Ser Glu Asp Asp Ala Ser Asp Thr Asn Pro Asp
                1525                1530                1535
Phe Tyr Ile Asn Ile Cys Gln Pro Leu Asn Pro Met His Gly Val Pro
            1540                1545                1550
Cys Pro Ala Gly Ala Ala Val Cys Lys Val Pro Ile Asp Gly Pro Pro
        1555                1560                1565
Ile Asp Ile Gly Arg Val Ala Gly Pro Pro Ile Leu Asn Pro Ile Ala
    1570                1575                1580
Asn Glu Ile Tyr Leu Asn Phe Glu Ser Ser Thr Pro Cys Leu Ala Asp
1585                1590                1595                1600
Lys His Phe Asn Tyr Thr Ser Leu Ile Ala Phe His Cys Lys Arg Gly
                1605                1610                1615
Val Ser Met Gly Thr Pro Lys Leu Leu Arg Thr Ser Glu Cys Asp Phe
            1620                1625                1630
Val Phe Glu Trp Glu Thr Pro Val Val Cys Pro Asp Glu Val Arg Met
        1635                1640                1645
Asp Gly Cys Thr Leu Thr Asp Glu Gln Leu Leu Tyr Ser Phe Asn Leu
    1650                1655                1660
Ser Ser Leu Ser Thr Ser Thr Phe Lys Val Thr Arg Asp Ser Arg Thr
1665                1670                1675                1680
Tyr Ser Val Gly Val Cys Thr Phe Ala Val Gly Pro Glu Gln Gly Gly
                1685                1690                1695
Cys Lys Asp Gly Gly Val Cys Leu Leu Ser Gly Thr Lys Gly Ala Ser
            1700                1705                1710
Phe Gly Arg Leu Gln Ser Met Lys Leu Asp Tyr Arg His Gln Asp Glu
        1715                1720                1725
Ala Val Val Leu Ser Tyr Val Asn Gly Asp Arg Cys Pro Pro Glu Thr
    1730                1735                1740
Asp Asp Gly Val Pro Cys Val Phe Pro Phe Ile Phe Asn Gly Lys Ser
1745                1750                1755                1760
Tyr Glu Glu Cys Ile Ile Glu Ser Arg Ala Lys Leu Trp Cys Ser Thr
                1765                1770                1775
Thr Ala Asp Tyr Asp Arg Asp His Glu Trp Gly Phe Cys Arg His Ser
            1780                1785                1790
Asn Ser Tyr Arg Thr Ser Ser Ile Ile Phe Lys Cys Asp Glu Asp Glu
        1795                1800                1805
Asp Ile Gly Arg Pro Gln Val Phe Ser Glu Val Arg Gly Cys Asp Val
    1810                1815                1820
Thr Phe Glu Trp Lys Thr Lys Val Val Cys Pro Pro Lys Lys Leu Glu
1825                1830                1835                1840
Cys Lys Phe Val Gln Lys His Lys Thr Tyr Asp Leu Arg Leu Leu Ser
                1845                1850                1855
Ser Leu Thr Gly Ser Trp Ser Leu Val His Asn Gly Val Ser Tyr Tyr
            1860                1865                1870
Ile Asn Leu Cys Gln Lys Ile Tyr Lys Gly Pro Leu Gly Cys Ser Glu
        1875                1880                1885
Arg Ala Ser Ile Cys Arg Arg Thr Thr Thr Gly Asp Val Gln Val Leu
    1890                1895                1900
Gly Leu Val His Thr Gln Lys Leu Gly Val Ile Gly Asp Lys Val Val
1905                1910                1915                1920
Val Thr Tyr Ser Lys Gly Tyr Pro Cys Gly Gly Asn Lys Thr Ala Ser
                1925                1930                1935
Ser Val Ile Glu Leu Thr Cys Thr Lys Thr Val Gly Arg Pro Ala Phe
            1940                1945                1950
Lys Arg Phe Asp Ile Asp Ser Cys Thr Tyr Tyr Phe Ser Trp Asp Ser
        1955                1960                1965
Arg Ala Ala Cys Ala Val Lys Pro Gln Glu Val Gln Met Val Asn Gly
    1970                1975                1980
Thr Ile Thr Asn Pro Ile Asn Gly Lys Ser Phe Ser Leu Gly Asp Ile
1985                1990                1995                2000
Tyr Phe Lys Leu Phe Arg Ala Ser Gly Asp Met Arg Thr Asn Gly Asp
                2005                2010                2015
Asn Tyr Leu Tyr Glu Ile Gln Leu Ser Ser Ile Thr Ser Ser Arg Asn
            2020                2025                2030
Pro Ala Cys Ser Gly Ala Asn Ile Cys Gln Val Lys Pro Asn Asp Gln
        2035                2040                2045
His Phe Ser Arg Lys Val Gly Thr Ser Asp Lys Thr Lys Tyr Tyr Leu
    2050                2055                2060
Gln Asp Gly Asp Leu Asp Val Val Phe Ala Ser Ser Ser Lys Cys Gly
2065                2070                2075                2080
Lys Asp Lys Thr Lys Ser Val Ser Ser Thr Ile Phe Phe His Cys Asp
                2085                2090                2095
Pro Leu Val Glu Asp Gly Ile Pro Glu Phe Ser His Glu Thr Ala Asp
            2100                2105                2110
Cys Gln Tyr Leu Phe Ser Trp Tyr Thr Ser Ala Val Cys Pro Leu Gly
        2115                2120                2125
Val Gly Phe Asp Ser Glu Asn Pro Gly Asp Asp Gly Gln Met His Lys
    2130                2135                2140
Gly Leu Ser Glu Arg Ser Gln Ala Val Gly Ala Val Leu Ser Leu Leu
2145                2150                2155                2160
Leu Val Ala Leu Thr Cys Cys Leu Leu Ala Leu Leu Leu Tyr Lys Lys
                2165                2170                2175
Glu Arg Arg Glu Thr Val Ile Ser Lys Leu Thr Thr Cys Cys Arg Arg
            2180                2185                2190
Ser Ser Asn Val Ser Tyr Lys Tyr Ser Lys Val Asn Lys Glu Glu Glu
        2195                2200                2205
Thr Asp Glu Asn Glu Thr Glu Trp Leu Met Glu Glu Ile Gln Leu Pro
    2210                2215                2220
Pro Pro Arg Gln Gly Lys Glu Gly Gln Glu Asn Gly His Ile Thr Thr
2225                2230                2235                2240
Lys Ser Val Lys Ala Leu Ser Ser Leu His Gly Asp Asp Gln Asp Ser
                2245                2250                2255
Glu Asp Glu Val Leu Thr Ile Pro Glu Val Lys Val His Ser Gly Arg
            2260                2265                2270
Gly Ala Gly Ala Glu Ser Ser His Pro Val Arg Asn Ala Gln Ser Asn
        2275                2280                2285
Ala Leu Gln Glu Arg Glu Asp Asp Arg Val Gly Leu Val Arg Gly Glu
    2290                2295                2300
Lys Ala Arg Lys Gly Lys Ser Ser Ser Ala Gln Gln Lys Thr Val Ser
2305                2310                2315                2320
Ser Thr Lys Leu Val Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu
                2325                2330                2335
His Ile


<210> 979
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 979
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala
 1               5                  10                  15
Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val
            20                  25                  30
Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu
        35                  40                  45
Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr
    50                  55                  60
Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser
65                  70                  75                  80
Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val
                85                  90                  95
Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn
            100                 105                 110
Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser
        115                 120                 125
Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val
    130                 135                 140
Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala
145                 150                 155                 160
Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val
                165                 170                 175
Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu
            180                 185                 190
Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe
        195                 200                 205
Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln
    210                 215                 220
Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His
225                 230                 235                 240
Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg
                245                 250                 255
Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu
            260                 265                 270
Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys
        275                 280                 285
Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser
    290                 295                 300
Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg
305                 310                 315                 320
Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp
                325                 330                 335
Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr
            340                 345                 350
Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu
        355                 360                 365
Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val
    370                 375                 380
Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn
385                 390                 395                 400
Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly
                405                 410                 415
Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe
            420                 425                 430
Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe
        435                 440                 445
Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr
    450                 455                 460
Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly
465                 470                 475                 480
Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu
                485                 490                 495
Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys
            500                 505                 510
His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala
        515                 520                 525
Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly
    530                 535                 540
Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly
545                 550                 555                 560
Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys
                565                 570                 575
Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu
            580                 585                 590
Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu
        595                 600                 605
Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly
    610                 615                 620
Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu
625                 630                 635                 640
Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys
                645                 650                 655
Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys
            660                 665                 670
Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr
        675                 680                 685
Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met
    690                 695                 700
Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His
705                 710                 715                 720
Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly
                725                 730                 735
Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe
            740                 745                 750
Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val
        755                 760                 765
Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala
    770                 775                 780
Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser
785                 790                 795                 800
Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro
                805                 810                 815
Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met
            820                 825                 830
Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser
        835                 840                 845
Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser
    850                 855                 860
Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly
865                 870                 875                 880
Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly
                885                 890                 895
Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val
            900                 905                 910
Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr
        915                 920                 925
Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val
    930                 935                 940
Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly
945                 950                 955                 960
Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys
                965                 970                 975
Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln
            980                 985                 990
Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg Pro Val Gly Ile Glu
        995                 1000                1005
Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile Thr Leu Thr Tyr Lys
    1010                1015                1020
Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala Phe Ile Val Arg Phe
1025                1030                1035                1040
Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu Lys Phe Leu His Gln
                1045                1050                1055
Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr Tyr Phe Glu Phe Glu
            1060                1065                1070
Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp Cys Gln Val Thr Asp
        1075                1080                1085
Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu Ser Thr Val Arg Lys
    1090                1095                1100
Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly Arg Lys Arg Thr Phe
1105                1110                1115                1120
Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile Pro Gly Cys Gln Gly
                1125                1130                1135
Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly Asn Ser Trp Asn Leu
            1140                1145                1150
Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala Asn Gly Ser Leu Ser
        1155                1160                1165
Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn Gln Arg Phe Ser Thr
    1170                1175                1180
Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly Ser Pro Ala Phe Gln
1185                1190                1195                1200
Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp Arg Thr Val Glu Ala
                1205                1210                1215
Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys Glu Val Lys Asp Pro
            1220                1225                1230
Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu Gly Leu Asn Asp Thr
        1235                1240                1245
Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe Arg Val Cys Gly Lys
    1250                1255                1260
Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys Ser Lys Val Val Ser
1265                1270                1275                1280
Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe His Lys Val Ala Gly
                1285                1290                1295
Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly Leu Leu Lys Met Asn
            1300                1305                1310
Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr Gln Arg Ser Thr Ala
        1315                1320                1325
Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg Pro Val Phe Leu Lys
    1330                1335                1340
Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp Arg Thr Gln Tyr Ala
1345                1350                1355                1360
Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe Lys Asp Gly Ala Gly
                1365                1370                1375
Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr Ser Asp Asn Trp Glu
            1380                1385                1390
Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr Leu Ile Asn Val Cys
        1395                1400                1405
Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro Cys Pro Pro Glu Ala
    1410                1415                1420
Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val Asn Leu Gly Arg Val
1425                1430                1435                1440
Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile Val Leu Lys Tyr Val
                1445                1450                1455
Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys Lys Ser Thr Thr Ile
            1460                1465                1470
Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser Arg Pro Met Phe Ile
        1475                1480                1485
Ser Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala Trp Pro Thr Ala Thr
    1490                1495                1500
Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp Cys Gln Val Thr Asn
1505                1510                1515                1520
Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg Ala
                1525                1530                1535
Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu Val Tyr Met Ser Ile
            1540                1545                1550
Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val Gly Ala Cys Phe Gly
        1555                1560                1565
Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys Arg Leu Arg Tyr Val
    1570                1575                1580
Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly Ser Pro Cys Pro Ser
1585                1590                1595                1600
Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser Phe Val Cys Arg Pro
                1605                1610                1615
Glu Ala Arg Pro Thr Asn Arg Pro Met Leu Ile Ser Leu Asp Lys Gln
            1620                1625                1630
Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro Leu Ala Cys Glu Gln
        1635                1640                1645
Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser Ile Val Asp Leu Ser
    1650                1655                1660
Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala Tyr Asp Glu Ser Glu
1665                1670                1675                1680
Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr Ile Asn Ile Cys Gln
                1685                1690                1695
Pro Leu Asn Pro Met His Gly Val Pro Cys Pro Ala Gly Ala Ala Val
            1700                1705                1710
Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp Ile Gly Arg Val Ala
        1715                1720                1725
Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu Ile Tyr Leu Asn Phe
    1730                1735                1740
Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His Phe Asn Tyr Thr Ser
1745                1750                1755                1760
Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser Met Gly Thr Pro Lys
                1765                1770                1775
Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe Glu Trp Glu Thr Pro
            1780                1785                1790
Val Val Cys Pro Asp Glu Val Arg Met Asp Gly Cys Thr Leu Thr Asp
        1795                1800                1805
Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser Leu Ser Thr Ser Thr
    1810                1815                1820
Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser Val Gly Val Cys Thr
1825                1830                1835                1840
Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys Asp Gly Gly Val Cys
                1845                1850                1855
Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly Arg Leu Gln Ser Met
            1860                1865                1870
Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val Val Leu Ser Tyr Val
        1875                1880                1885
Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp Gly Val Pro Cys Val
    1890                1895                1900
Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu Glu Cys Ile Ile Glu
1905                1910                1915                1920
Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala Asp Tyr Asp Arg Asp
                1925                1930                1935
His Glu Trp Gly Phe Cys Arg His Ser Asn Ser Tyr Arg Thr Ser Ser
            1940                1945                1950
Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile Gly Arg Pro Gln Val
        1955                1960                1965
Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe Glu Trp Lys Thr Lys
    1970                1975                1980
Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys Phe Val Gln Lys His
1985                1990                1995                2000
Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu Thr Gly Ser Trp Ser
                2005                2010                2015
Leu Val His Asn Gly Val Ser Tyr Tyr Ile Asn Leu Cys Gln Lys Ile
            2020                2025                2030
Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala Ser Ile Cys Arg Arg
        2035                2040                2045
Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu Val His Thr Gln Lys
    2050                2055                2060
Leu Gly Val Ile Gly Asp Lys Val Val Val Thr Tyr Ser Lys Gly Tyr
2065                2070                2075                2080
Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val Ile Glu Leu Thr Cys
                2085                2090                2095
Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg Phe Asp Ile Asp Ser
            2100                2105                2110
Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala Ala Cys Ala Val Lys
        2115                2120                2125
Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile Thr Asn Pro Ile Asn
    2130                2135                2140
Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe Lys Leu Phe Arg Ala
2145                2150                2155                2160
Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr Leu Tyr Glu Ile Gln
                2165                2170                2175
Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala Cys Ser Gly Ala Asn
            2180                2185                2190
Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe Ser Arg Lys Val Gly
        2195                2200                2205
Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp Gly Asp Leu Asp Val
    2210                2215                2220
Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp Lys Thr Lys Ser Val
2225                2230                2235                2240
Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu Val Glu Asp Gly Ile
                2245                2250                2255
Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln Tyr Leu Phe Ser Trp
            2260                2265                2270
Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly Phe Asp Ser Glu Asn
        2275                2280                2285
Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu Ser Glu Arg Ser Gln
    2290                2295                2300
Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val Ala Leu Thr Cys Cys
2305                2310                2315                2320
Leu Leu Ala Leu Leu Leu Tyr Lys Lys Glu Arg Arg Glu Thr Val Ile
                2325                2330                2335
Ser Lys Leu Thr Thr Cys Cys Arg Arg Ser Ser Asn Val Ser Tyr Lys
            2340                2345                2350
Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp Glu Asn Glu Thr Glu
        2355                2360                2365
Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro Arg Gln Gly Lys Glu
    2370                2375                2380
Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser Val Lys Ala Leu Ser
2385                2390                2395                2400
Ser Leu His Gly Asp Asp Gln Asp Ser Glu Asp Glu Val Leu Thr Ile
                2405                2410                2415
Pro Glu Val Lys Val His Ser Gly Arg Gly Ala Gly Ala Glu Ser Ser
            2420                2425                2430
His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu Gln Glu Arg Glu Asp
        2435                2440                2445
Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala Arg Lys Gly Lys Ser
    2450                2455                2460
Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr Lys Leu Val Ser Phe
2465                2470                2475                2480
His Asp Asp Ser Asp Glu Asp Leu Leu His Ile
                2485                2490

<210> 980
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 980
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala
 1               5                  10                  15
Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val
            20                  25                  30
Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu
        35                  40                  45
Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr
    50                  55                  60
Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser
65                  70                  75                  80
Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val
                85                  90                  95
Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn
            100                 105                 110
Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser
        115                 120                 125
Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val
    130                 135                 140
Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala
145                 150                 155                 160
Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val
                165                 170                 175
Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu
            180                 185                 190
Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe
        195                 200                 205
Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln
    210                 215                 220
Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His
225                 230                 235                 240
Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg
                245                 250                 255
Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu
            260                 265                 270
Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys
        275                 280                 285
Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser
    290                 295                 300
Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg
305                 310                 315                 320
Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp
                325                 330                 335
Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr
            340                 345                 350
Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu
        355                 360                 365
Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val
    370                 375                 380
Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn
385                 390                 395                 400
Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly
                405                 410                 415
Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe
            420                 425                 430
Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe
        435                 440                 445
Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr
    450                 455                 460
Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly
465                 470                 475                 480
Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu
                485                 490                 495
Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys
            500                 505                 510
His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala
        515                 520                 525
Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly
    530                 535                 540
Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly
545                 550                 555                 560
Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys
                565                 570                 575
Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu
            580                 585                 590
Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu
        595                 600                 605
Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly
    610                 615                 620
Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu
625                 630                 635                 640
Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys
                645                 650                 655
Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys
            660                 665                 670
Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr
        675                 680                 685
Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met
    690                 695                 700
Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His
705                 710                 715                 720
Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly
                725                 730                 735
Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe
            740                 745                 750
Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val
        755                 760                 765
Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala
    770                 775                 780
Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser
785                 790                 795                 800
Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro
                805                 810                 815
Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met
            820                 825                 830
Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser
        835                 840                 845
Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser
    850                 855                 860
Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly
865                 870                 875                 880
Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly
                885                 890                 895
Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val
            900                 905                 910
Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr
        915                 920                 925
Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val
    930                 935                 940
Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly
945                 950                 955                 960
Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys
                965                 970                 975
Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln
            980                 985                 990
Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg Pro Val Gly Ile Glu
        995                 1000                1005
Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile Thr Leu Thr Tyr Lys
    1010                1015                1020
Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala Phe Ile Val Arg Phe
1025                1030                1035                1040
Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu Lys Phe Leu His Gln
                1045                1050                1055
Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr Tyr Phe Glu Phe Glu
            1060                1065                1070
Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp Cys Gln Val Thr Asp
        1075                1080                1085
Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu Ser Thr Val Arg Lys
    1090                1095                1100
Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly Arg Lys Arg Thr Phe
1105                1110                1115                1120
Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile Pro Gly Cys Gln Gly
                1125                1130                1135
Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly Asn Ser Trp Asn Leu
            1140                1145                1150
Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala Asn Gly Ser Leu Ser
        1155                1160                1165
Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn Gln Arg Phe Ser Thr
    1170                1175                1180
Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly Ser Pro Ala Phe Gln
1185                1190                1195                1200
Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp Arg Thr Val Glu Ala
                1205                1210                1215
Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys Glu Val Lys Asp Pro
            1220                1225                1230
Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu Gly Leu Asn Asp Thr
        1235                1240                1245
Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe Arg Val Cys Gly Lys
    1250                1255                1260
Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys Ser Lys Val Val Ser
1265                1270                1275                1280
Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe His Lys Val Ala Gly
                1285                1290                1295
Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly Leu Leu Lys Met Asn
            1300                1305                1310
Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr Gln Arg Ser Thr Ala
        1315                1320                1325
Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg Pro Val Phe Leu Lys
    1330                1335                1340
Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp Arg Thr Gln Tyr Ala
1345                1350                1355                1360
Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe Lys Asp Gly Ala Gly
                1365                1370                1375
Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr Ser Asp Asn Trp Glu
            1380                1385                1390
Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr Leu Ile Asn Val Cys
        1395                1400                1405
Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro Cys Pro Pro Glu Ala
    1410                1415                1420
Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val Asn Leu Gly Arg Val
1425                1430                1435                1440
Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile Val Leu Lys Tyr Val
                1445                1450                1455
Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys Lys Ser Thr Thr Ile
            1460                1465                1470
Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser Arg Pro Met Phe Ile
        1475                1480                1485
Ser Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala Trp Pro Thr Ala Thr
    1490                1495                1500
Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp Cys Gln Val Thr Asn
1505                1510                1515                1520
Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg Ala
                1525                1530                1535
Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu Val Tyr Met Ser Ile
            1540                1545                1550
Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val Gly Ala Cys Phe Gly
        1555                1560                1565
Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys Arg Leu Arg Tyr Val
    1570                1575                1580
Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly Ser Pro Cys Pro Ser
1585                1590                1595                1600
Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser Phe Val Cys Arg Pro
                1605                1610                1615
Glu Ala Arg Pro Thr Asn Arg Pro Met Leu Ile Ser Leu Asp Lys Gln
            1620                1625                1630
Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro Leu Ala Cys Glu Gln
        1635                1640                1645
Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser Ile Val Asp Leu Ser
    1650                1655                1660
Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala Tyr Asp Glu Ser Glu
1665                1670                1675                1680
Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr Ile Asn Ile Cys Gln
                1685                1690                1695
Pro Leu Asn Pro Met His Gly Val Pro Cys Pro Ala Gly Ala Ala Val
            1700                1705                1710
Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp Ile Gly Arg Val Ala
        1715                1720                1725
Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu Ile Tyr Leu Asn Phe
    1730                1735                1740
Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His Phe Asn Tyr Thr Ser
1745                1750                1755                1760
Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser Met Gly Thr Pro Lys
                1765                1770                1775
Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe Glu Trp Glu Thr Pro
            1780                1785                1790
Val Val Cys Pro Asp Glu Val Arg Met Asp Gly Cys Thr Leu Thr Asp
        1795                1800                1805
Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser Leu Ser Thr Ser Thr
    1810                1815                1820
Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser Val Gly Val Cys Thr
1825                1830                1835                1840
Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys Asp Gly Gly Val Cys
                1845                1850                1855
Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly Arg Leu Gln Ser Met
            1860                1865                1870
Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val Val Leu Ser Tyr Val
        1875                1880                1885
Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp Gly Val Pro Cys Val
    1890                1895                1900
Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu Glu Cys Ile Ile Glu
1905                1910                1915                1920
Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala Asp Tyr Asp Arg Asp
                1925                1930                1935
His Glu Trp Gly Phe Cys Arg His Ser Asn Ser Tyr Arg Thr Ser Ser
            1940                1945                1950
Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile Gly Arg Pro Gln Val
        1955                1960                1965
Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe Glu Trp Lys Thr Lys
    1970                1975                1980
Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys Phe Val Gln Lys His
1985                1990                1995                2000
Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu Thr Gly Ser Trp Ser
                2005                2010                2015
Leu Val His Asn Gly Val Ser Tyr Tyr Ile Asn Leu Cys Gln Lys Ile
            2020                2025                2030
Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala Ser Ile Cys Arg Arg
        2035                2040                2045
Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu Val His Thr Gln Lys
    2050                2055                2060
Leu Gly Val Ile Gly Asp Lys Val Val Val Thr Tyr Ser Lys Gly Tyr
2065                2070                2075                2080
Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val Ile Glu Leu Thr Cys
                2085                2090                2095
Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg Phe Asp Ile Asp Ser
            2100                2105                2110
Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala Ala Cys Ala Val Lys
        2115                2120                2125
Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile Thr Asn Pro Ile Asn
    2130                2135                2140
Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe Lys Leu Phe Arg Ala
2145                2150                2155                2160
Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr Leu Tyr Glu Ile Gln
                2165                2170                2175
Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala Cys Ser Gly Ala Asn
            2180                2185                2190
Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe Ser Arg Lys Val Gly
        2195                2200                2205
Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp Gly Asp Leu Asp Val
    2210                2215                2220
Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp Lys Thr Lys Ser Val
2225                2230                2235                2240
Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu Val Glu Asp Gly Ile
                2245                2250                2255
Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln Tyr Leu Phe Ser Trp
            2260                2265                2270
Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly Phe Asp Ser Glu Asn
        2275                2280                2285
Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu Ser Glu Arg Ser Gln
    2290                2295                2300
Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val Ala Leu Thr Cys Cys
2305                2310                2315                2320
Leu Leu Ala Leu Leu Leu Tyr Lys Lys Glu Arg Arg Glu Thr Val Ile
                2325                2330                2335
Ser Lys Leu Thr Thr Cys Cys Arg Arg Ser Ser Asn Val Ser Tyr Lys
            2340                2345                2350
Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp Glu Asn Glu Thr Glu
        2355                2360                2365
Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro Arg Gln Gly Lys Glu
    2370                2375                2380
Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser Val Lys Ala Leu Ser
2385                2390                2395                2400
Ser Leu His Gly Asp Asp Gln Asp Ser Glu Asp Glu Val Leu Thr Ile
                2405                2410                2415
Pro Glu Val Lys Val His Ser Gly Arg Gly Ala Gly Ala Glu Ser Ser
            2420                2425                2430
His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu Gln Glu Arg Glu Asp
        2435                2440                2445
Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala Arg Lys Gly Lys Ser
    2450                2455                2460
Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr Lys Leu Val Ser Phe
2465                2470                2475                2480
His Asp Asp Ser Asp Glu Asp Leu Leu His Ile
                2485                2490

<210> 981
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 981
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala
 1               5                  10                  15
Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val
            20                  25                  30
Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu
        35                  40                  45
Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr
    50                  55                  60
Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser
65                  70                  75                  80
Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val
                85                  90                  95
Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn
            100                 105                 110
Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser
        115                 120                 125
Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val
    130                 135                 140
Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala
145                 150                 155                 160
Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val
                165                 170                 175
Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu
            180                 185                 190
Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe
        195                 200                 205
Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln
    210                 215                 220
Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His
225                 230                 235                 240
Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Val Val Arg
                245                 250                 255
Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu
            260                 265                 270
Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys
        275                 280                 285
Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser
    290                 295                 300
Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg
305                 310                 315                 320
Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp
                325                 330                 335
Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr
            340                 345                 350
Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu
        355                 360                 365
Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val
    370                 375                 380
Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn
385                 390                 395                 400
Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly
                405                 410                 415
Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe
            420                 425                 430
Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe
        435                 440                 445
Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr
    450                 455                 460
Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly
465                 470                 475                 480
Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu
                485                 490                 495
Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Lys Lys Lys
            500                 505                 510
His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala
        515                 520                 525
Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly
    530                 535                 540
Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly
545                 550                 555                 560
Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys
                565                 570                 575
Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu
            580                 585                 590
Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu
        595                 600                 605
Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly
    610                 615                 620
Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu
625                 630                 635                 640
Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys
                645                 650                 655
Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys
            660                 665                 670
Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr
        675                 680                 685
Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met
    690                 695                 700
Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His
705                 710                 715                 720
Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly
                725                 730                 735
Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe
            740                 745                 750
Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val
        755                 760                 765
Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala
    770                 775                 780
Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser
785                 790                 795                 800
Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro
                805                 810                 815
Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met
            820                 825                 830
Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Ala Ser Ile Ser
        835                 840                 845
Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser
    850                 855                 860
Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly
865                 870                 875                 880
Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly
                885                 890                 895
Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val
            900                 905                 910
Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr
        915                 920                 925
Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val
    930                 935                 940
Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly
945                 950                 955                 960
Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys
                965                 970                 975
Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln
            980                 985                 990
Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg Pro Val Gly Ile Glu
        995                 1000                1005
Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile Thr Leu Thr Tyr Lys
    1010                1015                1020
Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala Phe Ile Val Arg Phe
1025                1030                1035                1040
Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu Lys Phe Leu His Gln
                1045                1050                1055
Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr Tyr Phe Glu Phe Glu
            1060                1065                1070
Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp Cys Gln Val Thr Asp
        1075                1080                1085
Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu Ser Thr Val Arg Lys
    1090                1095                1100
Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly Arg Lys Arg Thr Phe
1105                1110                1115                1120
Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile Pro Gly Cys Gln Gly
                1125                1130                1135
Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly Asn Ser Trp Asn Leu
            1140                1145                1150
Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala Asn Gly Ser Leu Ser
        1155                1160                1165
Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn Gln Arg Phe Ser Thr
    1170                1175                1180
Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly Ser Pro Ala Phe Gln
1185                1190                1195                1200
Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp Arg Thr Val Glu Ala
                1205                1210                1215
Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys Glu Val Lys Asp Pro
            1220                1225                1230
Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu Gly Leu Asn Asp Thr
        1235                1240                1245
Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe Arg Val Cys Gly Lys
    1250                1255                1260
Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys Ser Lys Val Val Ser
1265                1270                1275                1280
Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe His Lys Val Ala Gly
                1285                1290                1295
Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly Leu Leu Lys Met Asn
            1300                1305                1310
Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr Gln Arg Ser Thr Ala
        1315                1320                1325
Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg Pro Val Phe Leu Lys
    1330                1335                1340
Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp Arg Thr Gln Tyr Ala
1345                1350                1355                1360
Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe Lys Asp Gly Ala Gly
                1365                1370                1375
Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr Ser Asp Asn Trp Glu
            1380                1385                1390
Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr Leu Ile Asn Val Cys
        1395                1400                1405
Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro Cys Pro Pro Glu Ala
    1410                1415                1420
Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val Asn Leu Gly Arg Val
1425                1430                1435                1440
Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile Val Leu Lys Tyr Val
                1445                1450                1455
Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys Lys Ser Thr Thr Ile
            1460                1465                1470
Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser Arg Pro Met Phe Ile
        1475                1480                1485
Asn Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala Trp Pro Thr Ala Thr
    1490                1495                1500
Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp Cys Gln Val Thr Asn
1505                1510                1515                1520
Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg Ala
                1525                1530                1535
Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu Val Tyr Met Ser Ile
            1540                1545                1550
Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val Gly Ala Cys Phe Gly
        1555                1560                1565
Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys Arg Leu Arg Tyr Val
    1570                1575                1580
Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly Ser Pro Cys Pro Ser
1585                1590                1595                1600
Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser Phe Val Cys Arg Pro
                1605                1610                1615
Glu Ala Gly Pro Thr Asn Arg Pro Met Leu Ile Ser Leu Asp Lys Gln
            1620                1625                1630
Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro Leu Ala Cys Glu Gln
        1635                1640                1645
Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser Ile Val Asp Leu Ser
    1650                1655                1660
Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala Tyr Asp Glu Ser Glu
1665                1670                1675                1680
Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr Ile Asn Ile Cys Gln
                1685                1690                1695
Pro Leu Asn Pro Met His Gly Val Pro Cys Pro Ala Gly Ala Ala Val
            1700                1705                1710
Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp Ile Gly Arg Val Ala
        1715                1720                1725
Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu Ile Tyr Leu Asn Phe
    1730                1735                1740
Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His Phe Asn Tyr Thr Ser
1745                1750                1755                1760
Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser Met Gly Thr Pro Lys
                1765                1770                1775
Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe Glu Trp Glu Thr Pro
            1780                1785                1790
Val Val Cys Pro Asp Glu Val Arg Met Asp Gly Cys Thr Leu Thr Asp
        1795                1800                1805
Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser Leu Ser Thr Ser Thr
    1810                1815                1820
Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser Val Gly Val Cys Thr
1825                1830                1835                1840
Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys Asp Gly Gly Val Cys
                1845                1850                1855
Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly Arg Leu Gln Ser Met
            1860                1865                1870
Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val Val Leu Ser Tyr Val
        1875                1880                1885
Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp Gly Val Pro Cys Val
    1890                1895                1900
Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu Glu Cys Ile Ile Glu
1905                1910                1915                1920
Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala Asp Tyr Asp Arg Asp
                1925                1930                1935
His Glu Trp Gly Phe Cys Arg His Ser Asn Ser Tyr Arg Thr Ser Ser
            1940                1945                1950
Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile Gly Arg Pro Gln Val
        1955                1960                1965
Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe Glu Trp Lys Thr Lys
    1970                1975                1980
Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys Phe Val Gln Lys His
1985                1990                1995                2000
Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu Thr Gly Ser Trp Ser
                2005                2010                2015
Leu Val His Asn Gly Val Ser Tyr Tyr Met Asn Leu Cys Gln Lys Ile
            2020                2025                2030
Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala Ser Ile Cys Arg Arg
        2035                2040                2045
Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu Val His Thr Gln Lys
    2050                2055                2060
Leu Gly Val Ile Gly Asp Lys Val Val Val Met Tyr Ser Lys Gly Tyr
2065                2070                2075                2080
Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val Ile Glu Leu Thr Cys
                2085                2090                2095
Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg Phe Asp Ile Asp Ser
            2100                2105                2110
Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala Ala Cys Ala Val Lys
        2115                2120                2125
Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile Thr Asn Pro Ile Asn
    2130                2135                2140
Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe Asn Leu Phe Arg Glu
2145                2150                2155                2160
Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr Leu Tyr Glu Ile Leu
                2165                2170                2175
Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala Cys Ser Gly Ala Asn
            2180                2185                2190
Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe Ser Arg Lys Val Gly
        2195                2200                2205
Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp Gly Asp Leu Asp Val
    2210                2215                2220
Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp Lys Thr Lys Ser Val
2225                2230                2235                2240
Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu Val Glu Asp Gly Ile
                2245                2250                2255
Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln Tyr Leu Phe Ser Trp
            2260                2265                2270
Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly Phe Asp Ser Glu Asn
        2275                2280                2285
Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu Ser Glu Arg Ser Gln
    2290                2295                2300
Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val Ala Leu Thr Cys Cys
2305                2310                2315                2320
Leu Leu Ala Leu Leu Leu Tyr Lys Lys Lys Arg Arg Glu Thr Met Ile
                2325                2330                2335
Ser Lys Leu Thr Ser Cys Cys Arg Arg Ser Ser Asn Val Ser Tyr Lys
            2340                2345                2350
Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp Glu Asn Glu Thr Glu
        2355                2360                2365
Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro Arg Gln Gly Lys Glu
    2370                2375                2380
Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser Val Lys Ala Leu Ser
2385                2390                2395                2400
Ser Leu His Gly Asp Asp Gln Asp Ser Thr Asp Glu Val Leu Thr Ile
                2405                2410                2415
Pro Glu Val Lys Val His Ser Gly Arg Gly Ala Gly Ala Glu Ser Ser
            2420                2425                2430
His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu Gln Glu Arg Glu Asp
        2435                2440                2445
Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala Arg Lys Gly Lys Ser
    2450                2455                2460
Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr Lys Leu Val Ser Phe
2465                2470                2475                2480
His Asp Asp Ser Asp Glu Asp Leu Leu His Ile
                2485                2490

<210> 982
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 982
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala
 1               5                  10                  15
Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val
            20                  25                  30
Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu
        35                  40                  45
Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr
    50                  55                  60
Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser
65                  70                  75                  80
Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val
                85                  90                  95
Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn
            100                 105                 110
Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser
        115                 120                 125
Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val
    130                 135                 140
Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala
145                 150                 155                 160
Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val
                165                 170                 175
Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu
            180                 185                 190
Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe
        195                 200                 205
Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln
    210                 215                 220
Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His
225                 230                 235                 240
Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg
                245                 250                 255
Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu
            260                 265                 270
Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys
        275                 280                 285
Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser
    290                 295                 300
Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg
305                 310                 315                 320
Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp
                325                 330                 335
Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr
            340                 345                 350
Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu
        355                 360                 365
Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val
    370                 375                 380
Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn
385                 390                 395                 400
Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly
                405                 410                 415
Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe
            420                 425                 430
Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe
        435                 440                 445
Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr
    450                 455                 460
Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly
465                 470                 475                 480
Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu
                485                 490                 495
Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys
            500                 505                 510
His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala
        515                 520                 525
Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly
    530                 535                 540
Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly
545                 550                 555                 560
Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys
                565                 570                 575
Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu
            580                 585                 590
Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu
        595                 600                 605
Phe Glu Trp Arg Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly
    610                 615                 620
Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu
625                 630                 635                 640
Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys
                645                 650                 655
Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys
            660                 665                 670
Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr
        675                 680                 685
Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met
    690                 695                 700
Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His
705                 710                 715                 720
Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly
                725                 730                 735
Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe
            740                 745                 750
Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val
        755                 760                 765
Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala
    770                 775                 780
Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser
785                 790                 795                 800
Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro
                805                 810                 815
Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met
            820                 825                 830
Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser
        835                 840                 845
Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser
    850                 855                 860
Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly
865                 870                 875                 880
Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly
                885                 890                 895
Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val
            900                 905                 910
Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr
        915                 920                 925
Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val
    930                 935                 940
Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly
945                 950                 955                 960
Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys
                965                 970                 975
Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln
            980                 985                 990
Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg Pro Val Gly Ile Glu
        995                 1000                1005
Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile Thr Leu Thr Tyr Lys
    1010                1015                1020
Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala Phe Ile Val Arg Phe
1025                1030                1035                1040
Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu Lys Phe Leu His Gln
                1045                1050                1055
Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr Tyr Phe Glu Phe Glu
            1060                1065                1070
Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp Cys Gln Val Thr Asp
        1075                1080                1085
Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu Ser Thr Val Arg Lys
    1090                1095                1100
Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly Arg Lys Arg Thr Phe
1105                1110                1115                1120
Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile Pro Gly Cys Gln Gly
                1125                1130                1135
Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly Asn Ser Trp Asn Leu
            1140                1145                1150
Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala Asn Gly Ser Leu Ser
        1155                1160                1165
Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn Gln Arg Phe Ser Thr
    1170                1175                1180
Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly Ser Pro Ala Phe Gln
1185                1190                1195                1200
Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp Arg Thr Val Glu Ala
                1205                1210                1215
Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys Glu Val Lys Asp Pro
            1220                1225                1230
Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu Gly Leu Asn Asp Thr
        1235                1240                1245
Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe Arg Val Cys Gly Lys
    1250                1255                1260
Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys Ser Lys Val Val Ser
1265                1270                1275                1280
Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe His Lys Val Ala Gly
                1285                1290                1295
Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly Leu Leu Lys Met Asn
            1300                1305                1310
Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr Gln Arg Ser Thr Ala
        1315                1320                1325
Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg Pro Val Phe Leu Lys
    1330                1335                1340
Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp Arg Thr Gln Tyr Ala
1345                1350                1355                1360
Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe Lys Asp Gly Ala Gly
                1365                1370                1375
Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr Ser Asp Asn Trp Glu
            1380                1385                1390
Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr Leu Ile Asn Val Cys
        1395                1400                1405
Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro Cys Pro Pro Glu Ala
    1410                1415                1420
Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val Asn Leu Gly Arg Val
1425                1430                1435                1440
Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile Val Leu Lys Tyr Val
                1445                1450                1455
Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys Lys Ser Thr Thr Ile
            1460                1465                1470
Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser Arg Pro Met Phe Ile
        1475                1480                1485
Ser Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala Trp Pro Thr Ala Thr
    1490                1495                1500
Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp Cys Gln Val Thr Asn
1505                1510                1515                1520
Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg Ala
                1525                1530                1535
Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu Val Tyr Met Ser Ile
            1540                1545                1550
Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val Gly Ala Cys Phe Gly
        1555                1560                1565
Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys Arg Leu Arg Tyr Val
    1570                1575                1580
Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly Ser Pro Cys Pro Ser
1585                1590                1595                1600
Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser Phe Val Cys Arg Pro
                1605                1610                1615
Glu Ala Gly Pro Thr Asn Arg Pro Met Leu Ile Ser Leu Asp Lys Gln
            1620                1625                1630
Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro Leu Ala Cys Glu Gln
        1635                1640                1645
Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser Ile Val Asp Leu Ser
    1650                1655                1660
Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala Tyr Asp Glu Ser Glu
1665                1670                1675                1680
Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr Ile Asn Ile Cys Gln
                1685                1690                1695
Pro Leu Asn Pro Met His Ala Val Pro Cys Pro Ala Gly Ala Ala Val
            1700                1705                1710
Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp Ile Gly Arg Val Ala
        1715                1720                1725
Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu Ile Tyr Leu Asn Phe
    1730                1735                1740
Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His Phe Asn Tyr Thr Ser
1745                1750                1755                1760
Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser Met Gly Thr Pro Lys
                1765                1770                1775
Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe Glu Trp Glu Thr Pro
            1780                1785                1790
Val Val Cys Pro Asp Glu Val Arg Met Asp Gly Cys Thr Leu Thr Asp
        1795                1800                1805
Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser Leu Ser Thr Ser Thr
    1810                1815                1820
Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser Val Gly Val Cys Thr
1825                1830                1835                1840
Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys Asp Gly Gly Val Cys
                1845                1850                1855
Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly Arg Leu Gln Ser Met
            1860                1865                1870
Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val Val Leu Ser Tyr Val
        1875                1880                1885
Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp Gly Val Pro Cys Val
    1890                1895                1900
Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu Glu Cys Ile Ile Glu
1905                1910                1915                1920
Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala Asp Tyr Asp Arg Asp
                1925                1930                1935
His Glu Trp Gly Phe Cys Arg His Ser Asn Ser Tyr Arg Thr Ser Ser
            1940                1945                1950
Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile Gly Arg Pro Gln Val
        1955                1960                1965
Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe Glu Trp Lys Thr Lys
    1970                1975                1980
Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys Phe Val Gln Lys His
1985                1990                1995                2000
Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu Thr Gly Ser Trp Ser
                2005                2010                2015
Leu Val His Asn Gly Val Ser Tyr Tyr Ile Asn Leu Cys Gln Lys Ile
            2020                2025                2030
Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala Ser Ile Cys Arg Arg
        2035                2040                2045
Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu Val His Thr Gln Lys
    2050                2055                2060
Leu Gly Val Ile Gly Asp Lys Val Val Val Thr Tyr Ser Lys Gly Tyr
2065                2070                2075                2080
Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val Ile Glu Leu Thr Cys
                2085                2090                2095
Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg Phe Asp Ile Asp Ser
            2100                2105                2110
Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala Ala Cys Ala Val Lys
        2115                2120                2125
Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile Thr Asn Pro Ile Asn
    2130                2135                2140
Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe Lys Leu Phe Arg Ala
2145                2150                2155                2160
Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr Leu Tyr Glu Ile Gln
                2165                2170                2175
Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala Cys Ser Gly Ala Asn
            2180                2185                2190
Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe Ser Arg Lys Val Gly
        2195                2200                2205
Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp Gly Asp Leu Asp Val
    2210                2215                2220
Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp Lys Thr Lys Ser Val
2225                2230                2235                2240
Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu Val Glu Asp Gly Ile
                2245                2250                2255
Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln Tyr Leu Phe Ser Trp
            2260                2265                2270
Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly Phe Asp Ser Glu Asn
        2275                2280                2285
Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu Ser Glu Arg Ser Gln
    2290                2295                2300
Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val Ala Leu Thr Cys Cys
2305                2310                2315                2320
Leu Leu Ala Leu Leu Leu Tyr Lys Lys Glu Arg Arg Glu Thr Val Ile
                2325                2330                2335
Ser Lys Leu Thr Thr Cys Cys Arg Arg Ser Ser Asn Val Ser Tyr Lys
            2340                2345                2350
Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp Glu Asn Glu Thr Glu
        2355                2360                2365
Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro Arg Gln Gly Lys Glu
    2370                2375                2380
Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser Val Lys Ala Leu Ser
2385                2390                2395                2400
Ser Leu His Gly Asp Asp Gln Asp Ser Glu Asp Glu Val Leu Thr Ile
                2405                2410                2415
Pro Glu Val Lys Val His Ser Gly Arg Gly Ala Gly Ala Glu Ser Ser
            2420                2425                2430
His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu Gln Glu Arg Glu Asp
        2435                2440                2445
Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala Arg Lys Gly Lys Ser
    2450                2455                2460
Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr Lys Leu Val Ser Phe
2465                2470                2475                2480
His Asp Asp Ser Asp Glu Asp Leu Leu His Ile
                2485                2490

<210> 983
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 983
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala
 1               5                  10                  15
Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val
            20                  25                  30
Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu
        35                  40                  45
Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr
    50                  55                  60
Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser
65                  70                  75                  80
Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val
                85                  90                  95
Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn
            100                 105                 110
Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser
        115                 120                 125
Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val
    130                 135                 140
Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala
145                 150                 155                 160
Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val
                165                 170                 175
Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu
            180                 185                 190
Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe
        195                 200                 205
Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln
    210                 215                 220
Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His
225                 230                 235                 240
Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg
                245                 250                 255
Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu
            260                 265                 270
Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys
        275                 280                 285
Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser
    290                 295                 300
Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg
305                 310                 315                 320
Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp
                325                 330                 335
Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr
            340                 345                 350
Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu
        355                 360                 365
Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val
    370                 375                 380
Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn
385                 390                 395                 400
Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly
                405                 410                 415
Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe
            420                 425                 430
Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe
        435                 440                 445
Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr
    450                 455                 460
Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly
465                 470                 475                 480
Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu
                485                 490                 495
Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys
            500                 505                 510
His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala
        515                 520                 525
Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly
    530                 535                 540
Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly
545                 550                 555                 560
Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys
                565                 570                 575
Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu
            580                 585                 590
Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu
        595                 600                 605
Phe Glu Trp Arg Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly
    610                 615                 620
Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu
625                 630                 635                 640
Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys
                645                 650                 655
Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys
            660                 665                 670
Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr
        675                 680                 685
Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met
    690                 695                 700
Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His
705                 710                 715                 720
Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly
                725                 730                 735
Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe
            740                 745                 750
Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val
        755                 760                 765
Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala
    770                 775                 780
Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser
785                 790                 795                 800
Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro
                805                 810                 815
Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met
            820                 825                 830
Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser
        835                 840                 845
Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser
    850                 855                 860
Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly
865                 870                 875                 880
Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly
                885                 890                 895
Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val
            900                 905                 910
Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr
        915                 920                 925
Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val
    930                 935                 940
Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly
945                 950                 955                 960
Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys
                965                 970                 975
Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln
            980                 985                 990
Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg Pro Val Gly Ile Glu
        995                 1000                1005
Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile Thr Leu Thr Tyr Lys
    1010                1015                1020
Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala Phe Ile Val Arg Phe
1025                1030                1035                1040
Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu Lys Phe Leu His Gln
                1045                1050                1055
Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr Tyr Phe Glu Phe Glu
            1060                1065                1070
Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp Cys Gln Val Thr Asp
        1075                1080                1085
Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu Ser Thr Val Arg Lys
    1090                1095                1100
Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly Arg Lys Arg Thr Phe
1105                1110                1115                1120
Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile Pro Gly Cys Gln Gly
                1125                1130                1135
Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly Asn Ser Trp Asn Leu
            1140                1145                1150
Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala Asn Gly Ser Leu Ser
        1155                1160                1165
Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn Gln Arg Phe Ser Thr
    1170                1175                1180
Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly Ser Pro Ala Phe Gln
1185                1190                1195                1200
Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp Arg Thr Val Glu Ala
                1205                1210                1215
Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys Glu Val Lys Asp Pro
            1220                1225                1230
Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu Gly Leu Asn Asp Thr
        1235                1240                1245
Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe Arg Val Cys Gly Lys
    1250                1255                1260
Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys Ser Lys Val Val Ser
1265                1270                1275                1280
Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe His Lys Val Ala Gly
                1285                1290                1295
Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly Leu Leu Lys Met Asn
            1300                1305                1310
Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr Gln Arg Ser Thr Ala
        1315                1320                1325
Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg Pro Val Phe Leu Lys
    1330                1335                1340
Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp Arg Thr Gln Tyr Ala
1345                1350                1355                1360
Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe Lys Asp Gly Ala Gly
                1365                1370                1375
Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr Ser Asp Asn Trp Glu
            1380                1385                1390
Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr Leu Ile Asn Val Cys
        1395                1400                1405
Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro Cys Pro Pro Glu Ala
    1410                1415                1420
Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val Asn Leu Gly Arg Val
1425                1430                1435                1440
Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile Val Leu Lys Tyr Val
                1445                1450                1455
Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys Lys Ser Thr Thr Ile
            1460                1465                1470
Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser Arg Pro Met Phe Ile
        1475                1480                1485
Ser Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala Trp Pro Thr Ala Thr
    1490                1495                1500
Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp Cys Gln Val Thr Asn
1505                1510                1515                1520
Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg Ala
                1525                1530                1535
Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu Val Tyr Met Ser Ile
            1540                1545                1550
Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val Gly Ala Cys Phe Gly
        1555                1560                1565
Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys Arg Leu Arg Tyr Val
    1570                1575                1580
Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly Ser Pro Cys Pro Ser
1585                1590                1595                1600
Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser Phe Val Cys Arg Pro
                1605                1610                1615
Glu Ala Gly Pro Thr Asn Arg Pro Met Leu Ile Ser Leu Asp Lys Gln
            1620                1625                1630
Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro Leu Ala Cys Glu Gln
        1635                1640                1645
Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser Ile Val Asp Leu Ser
    1650                1655                1660
Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala Tyr Asp Glu Ser Glu
1665                1670                1675                1680
Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr Ile Asn Ile Cys Gln
                1685                1690                1695
Pro Leu Asn Pro Met His Ala Val Pro Cys Pro Ala Gly Ala Ala Val
            1700                1705                1710
Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp Ile Gly Arg Val Ala
        1715                1720                1725
Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu Ile Tyr Leu Asn Phe
    1730                1735                1740
Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His Phe Asn Tyr Thr Ser
1745                1750                1755                1760
Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser Met Gly Thr Pro Lys
                1765                1770                1775
Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe Glu Trp Glu Thr Pro
            1780                1785                1790
Val Val Cys Pro Asp Glu Val Arg Met Asp Gly Cys Thr Leu Thr Asp
        1795                1800                1805
Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser Leu Ser Thr Ser Thr
    1810                1815                1820
Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser Val Gly Val Cys Thr
1825                1830                1835                1840
Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys Asp Gly Gly Val Cys
                1845                1850                1855
Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly Arg Leu Gln Ser Met
            1860                1865                1870
Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val Val Leu Ser Tyr Val
        1875                1880                1885
Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp Gly Val Pro Cys Val
    1890                1895                1900
Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu Glu Cys Ile Ile Glu
1905                1910                1915                1920
Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala Asp Tyr Asp Arg Asp
                1925                1930                1935
His Glu Trp Gly Phe Cys Arg His Ser Asn Ser Tyr Arg Thr Ser Ser
            1940                1945                1950
Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile Gly Arg Pro Gln Val
        1955                1960                1965
Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe Glu Trp Lys Thr Lys
    1970                1975                1980
Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys Phe Val Gln Lys His
1985                1990                1995                2000
Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu Thr Gly Ser Trp Ser
                2005                2010                2015
Leu Val His Asn Gly Val Ser Tyr Tyr Ile Asn Leu Cys Gln Lys Ile
            2020                2025                2030
Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala Ser Ile Cys Arg Arg
        2035                2040                2045
Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu Val His Thr Gln Lys
    2050                2055                2060
Leu Gly Val Ile Gly Asp Lys Val Val Val Thr Tyr Ser Lys Gly Tyr
2065                2070                2075                2080
Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val Ile Glu Leu Thr Cys
                2085                2090                2095
Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg Phe Asp Ile Asp Ser
            2100                2105                2110
Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala Ala Cys Ala Val Lys
        2115                2120                2125
Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile Thr Asn Pro Ile Asn
    2130                2135                2140
Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe Lys Leu Phe Arg Ala
2145                2150                2155                2160
Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr Leu Tyr Glu Ile Gln
                2165                2170                2175
Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala Cys Ser Gly Ala Asn
            2180                2185                2190
Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe Ser Arg Lys Val Gly
        2195                2200                2205
Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp Gly Asp Leu Asp Val
    2210                2215                2220
Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp Lys Thr Lys Ser Val
2225                2230                2235                2240
Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu Val Glu Asp Gly Ile
                2245                2250                2255
Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln Tyr Leu Phe Ser Trp
            2260                2265                2270
Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly Phe Asp Ser Glu Asn
        2275                2280                2285
Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu Ser Glu Arg Ser Gln
    2290                2295                2300
Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val Ala Leu Thr Cys Cys
2305                2310                2315                2320
Leu Leu Ala Leu Leu Leu Tyr Lys Lys Glu Arg Arg Glu Thr Val Ile
                2325                2330                2335
Ser Lys Leu Thr Thr Cys Cys Arg Arg Ser Ser Asn Val Ser Tyr Lys
            2340                2345                2350
Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp Glu Asn Glu Thr Glu
        2355                2360                2365
Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro Arg Gln Gly Lys Glu
    2370                2375                2380
Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser Val Lys Ala Leu Ser
2385                2390                2395                2400
Ser Leu His Gly Asp Asp Gln Asp Ser Glu Asp Glu Val Leu Thr Ile
                2405                2410                2415
Pro Glu Val Lys Val His Ser Gly Arg Gly Ala Gly Ala Glu Ser Ser
            2420                2425                2430
His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu Gln Glu Arg Glu Asp
        2435                2440                2445
Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala Arg Lys Gly Lys Ser
    2450                2455                2460
Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr Lys Leu Val Ser Phe
2465                2470                2475                2480
His Asp Asp Ser Asp Glu Asp Leu Leu His Ile
                2485                2490

<210> 984
<211> 849
<212> PRT
<213> Homo sapiens

<400> 984
Ile Arg His Glu Val Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro
 1               5                  10                  15
Ile Gln Thr Thr Thr Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro
            20                  25                  30
Asn Ser Gly Phe Val Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly
        35                  40                  45
Tyr Asn Val Ser Gly Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly
    50                  55                  60
Thr Met Pro Val Cys Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys
65                  70                  75                  80
Glu Ala Glu Thr Gln Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg
                85                  90                  95
Pro Val Gly Ile Glu Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile
            100                 105                 110
Thr Leu Thr Tyr Lys Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala
        115                 120                 125
Phe Ile Val Arg Phe Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu
    130                 135                 140
Lys Phe Leu His Gln Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr
145                 150                 155                 160
Tyr Phe Glu Phe Glu Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp
                165                 170                 175
Cys Gln Val Thr Asp Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu
            180                 185                 190
Ser Thr Val Arg Lys Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly
        195                 200                 205
Arg Lys Arg Thr Phe Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile
    210                 215                 220
Pro Gly Cys Gln Gly Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly
225                 230                 235                 240
Asn Ser Trp Asn Leu Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala
                245                 250                 255
Asn Gly Ser Leu Ser Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn
            260                 265                 270
Gln Arg Phe Ser Thr Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly
        275                 280                 285
Ser Pro Ala Phe Gln Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp
    290                 295                 300
Arg Thr Val Glu Ala Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys
305                 310                 315                 320
Glu Val Lys Asp Pro Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu
                325                 330                 335
Gly Leu Asn Asp Thr Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe
            340                 345                 350
Arg Val Cys Gly Lys Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys
        355                 360                 365
Ser Lys Val Val Ser Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe
    370                 375                 380
His Lys Val Ala Gly Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly
385                 390                 395                 400
Leu Leu Lys Met Asn Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr
                405                 410                 415
Gln Arg Ser Thr Ala Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg
            420                 425                 430
Pro Val Phe Leu Lys Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp
        435                 440                 445
Arg Thr Gln Tyr Ala Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe
    450                 455                 460
Lys Asp Gly Ala Gly Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr
465                 470                 475                 480
Ser Asp Asn Trp Glu Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr
                485                 490                 495
Leu Ile Asn Val Cys Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro
            500                 505                 510
Cys Pro Pro Glu Ala Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val
        515                 520                 525
Asn Leu Gly Arg Val Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile
    530                 535                 540
Val Leu Lys Tyr Val Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys
545                 550                 555                 560
Lys Ser Thr Thr Ile Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser
                565                 570                 575
Arg Pro Met Phe Ile Ser Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala
            580                 585                 590
Trp Pro Thr Ala Thr Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp
        595                 600                 605
Cys Gln Val Thr Asn Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser
    610                 615                 620
Leu Ser Gly Arg Ala Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu
625                 630                 635                 640
Val Tyr Met Ser Ile Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val
                645                 650                 655
Gly Ala Cys Phe Gly Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys
            660                 665                 670
Arg Leu Arg Tyr Val Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly
        675                 680                 685
Ser Pro Cys Pro Ser Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser
    690                 695                 700
Phe Val Cys Arg Pro Glu Ala Gly Pro Thr Asn Arg Pro Met Leu Ile
705                 710                 715                 720
Ser Leu Asp Lys Gln Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro
                725                 730                 735
Leu Ala Cys Glu Gln Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser
            740                 745                 750
Ile Val Asp Leu Ser Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala
        755                 760                 765
Tyr Asp Glu Ser Glu Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr
    770                 775                 780
Ile Asn Ile Cys Gln Pro Leu Asn Pro Met His Gly Val Pro Cys Pro
785                 790                 795                 800
Ala Gly Ala Ala Val Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp
                805                 810                 815
Ile Gly Arg Val Ala Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu
            820                 825                 830
Ile Tyr Leu Asn Phe Glu Ser Ser Thr Pro Cys Gln Glu Phe Ser Cys
        835                 840                 845
Lys


<210> 985
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 985
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala
 1               5                  10                  15
Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val
            20                  25                  30
Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu
        35                  40                  45
Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr
    50                  55                  60
Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser
65                  70                  75                  80
Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val
                85                  90                  95
Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn
            100                 105                 110
Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser
        115                 120                 125
Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val
    130                 135                 140
Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala
145                 150                 155                 160
Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val
                165                 170                 175
Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu
            180                 185                 190
Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe
        195                 200                 205
Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln
    210                 215                 220
Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His
225                 230                 235                 240
Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg
                245                 250                 255
Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu
            260                 265                 270
Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys
        275                 280                 285
Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser
    290                 295                 300
Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg
305                 310                 315                 320
Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp
                325                 330                 335
Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr
            340                 345                 350
Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu
        355                 360                 365
Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val
    370                 375                 380
Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn
385                 390                 395                 400
Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly
                405                 410                 415
Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe
            420                 425                 430
Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe
        435                 440                 445
Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr
    450                 455                 460
Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly
465                 470                 475                 480
Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu
                485                 490                 495
Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys
            500                 505                 510
His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala
        515                 520                 525
Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly
    530                 535                 540
Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly
545                 550                 555                 560
Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys
                565                 570                 575
Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu
            580                 585                 590
Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu
        595                 600                 605
Phe Glu Trp Arg Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly
    610                 615                 620
Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu
625                 630                 635                 640
Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys
                645                 650                 655
Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys
            660                 665                 670
Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr
        675                 680                 685
Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met
    690                 695                 700
Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His
705                 710                 715                 720
Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly
                725                 730                 735
Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe
            740                 745                 750
Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val
        755                 760                 765
Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala
    770                 775                 780
Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser
785                 790                 795                 800
Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro
                805                 810                 815
Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met
            820                 825                 830
Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser
        835                 840                 845
Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser
    850                 855                 860
Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly
865                 870                 875                 880
Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly
                885                 890                 895
Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val
            900                 905                 910
Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr
        915                 920                 925
Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val
    930                 935                 940
Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly
945                 950                 955                 960
Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys
                965                 970                 975
Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln
            980                 985                 990
Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg Pro Val Gly Ile Glu
        995                 1000                1005
Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile Thr Leu Thr Tyr Lys
    1010                1015                1020
Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala Phe Ile Val Arg Phe
1025                1030                1035                1040
Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu Lys Phe Leu His Gln
                1045                1050                1055
Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr Tyr Phe Glu Phe Glu
            1060                1065                1070
Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp Cys Gln Val Thr Asp
        1075                1080                1085
Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu Ser Thr Val Arg Lys
    1090                1095                1100
Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly Arg Lys Arg Thr Phe
1105                1110                1115                1120
Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile Pro Gly Cys Gln Gly
                1125                1130                1135
Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly Asn Ser Trp Asn Leu
            1140                1145                1150
Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala Asn Gly Ser Leu Ser
        1155                1160                1165
Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn Gln Arg Phe Ser Thr
    1170                1175                1180
Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly Ser Pro Ala Phe Gln
1185                1190                1195                1200
Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp Arg Thr Val Glu Ala
                1205                1210                1215
Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys Glu Val Lys Asp Pro
            1220                1225                1230
Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu Gly Leu Asn Asp Thr
        1235                1240                1245
Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe Arg Val Cys Gly Lys
    1250                1255                1260
Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys Ser Lys Val Val Ser
1265                1270                1275                1280
Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe His Lys Val Ala Gly
                1285                1290                1295
Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly Leu Leu Lys Met Asn
            1300                1305                1310
Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr Gln Arg Ser Thr Ala
        1315                1320                1325
Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg Pro Val Phe Leu Lys
    1330                1335                1340
Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp Arg Thr Gln Tyr Ala
1345                1350                1355                1360
Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe Lys Asp Gly Ala Gly
                1365                1370                1375
Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr Ser Asp Asn Trp Glu
            1380                1385                1390
Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr Leu Ile Asn Val Cys
        1395                1400                1405
Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro Cys Pro Pro Glu Ala
    1410                1415                1420
Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val Asn Leu Gly Arg Val
1425                1430                1435                1440
Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile Val Leu Lys Tyr Val
                1445                1450                1455
Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys Lys Ser Thr Thr Ile
            1460                1465                1470
Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser Arg Pro Met Phe Ile
        1475                1480                1485
Ser Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala Trp Pro Thr Ala Thr
    1490                1495                1500
Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp Cys Gln Val Thr Asn
1505                1510                1515                1520
Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg Ala
                1525                1530                1535
Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu Val Tyr Met Ser Ile
            1540                1545                1550
Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val Gly Ala Cys Phe Gly
        1555                1560                1565
Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys Arg Leu Arg Tyr Val
    1570                1575                1580
Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly Ser Pro Cys Pro Ser
1585                1590                1595                1600
Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser Phe Val Cys Arg Pro
                1605                1610                1615
Glu Ala Gly Pro Thr Asn Arg Pro Met Leu Ile Ser Leu Asp Lys Gln
            1620                1625                1630
Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro Leu Ala Cys Glu Gln
        1635                1640                1645
Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser Ile Val Asp Leu Ser
    1650                1655                1660
Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala Tyr Asp Glu Ser Glu
1665                1670                1675                1680
Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr Ile Asn Ile Cys Gln
                1685                1690                1695
Pro Leu Asn Pro Met His Ala Val Pro Cys Pro Ala Gly Ala Ala Val
            1700                1705                1710
Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp Ile Gly Arg Val Ala
        1715                1720                1725
Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu Ile Tyr Leu Asn Phe
    1730                1735                1740
Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His Phe Asn Tyr Thr Ser
1745                1750                1755                1760
Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser Met Gly Thr Pro Lys
                1765                1770                1775
Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe Glu Trp Glu Thr Pro
            1780                1785                1790
Val Val Cys Pro Asp Glu Val Arg Met Asp Gly Cys Thr Leu Thr Asp
        1795                1800                1805
Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser Leu Ser Thr Ser Thr
    1810                1815                1820
Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser Val Gly Val Cys Thr
1825                1830                1835                1840
Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys Asp Gly Gly Val Cys
                1845                1850                1855
Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly Arg Leu Gln Ser Met
            1860                1865                1870
Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val Val Leu Ser Tyr Val
        1875                1880                1885
Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp Gly Val Pro Cys Val
    1890                1895                1900
Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu Glu Cys Ile Ile Glu
1905                1910                1915                1920
Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala Asp Tyr Asp Arg Asp
                1925                1930                1935
His Glu Trp Gly Phe Cys Arg His Ser Asn Ser Tyr Arg Thr Ser Ser
            1940                1945                1950
Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile Gly Arg Pro Gln Val
        1955                1960                1965
Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe Glu Trp Lys Thr Lys
    1970                1975                1980
Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys Phe Val Gln Lys His
1985                1990                1995                2000
Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu Thr Gly Ser Trp Ser
                2005                2010                2015
Leu Val His Asn Gly Val Ser Tyr Tyr Ile Asn Leu Cys Gln Lys Ile
            2020                2025                2030
Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala Ser Ile Cys Arg Arg
        2035                2040                2045
Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu Val His Thr Gln Lys
    2050                2055                2060
Leu Gly Val Ile Gly Asp Lys Val Val Val Thr Tyr Ser Lys Gly Tyr
2065                2070                2075                2080
Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val Ile Glu Leu Thr Cys
                2085                2090                2095
Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg Phe Asp Ile Asp Ser
            2100                2105                2110
Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala Ala Cys Ala Val Lys
        2115                2120                2125
Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile Thr Asn Pro Ile Asn
    2130                2135                2140
Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe Lys Leu Phe Arg Ala
2145                2150                2155                2160
Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr Leu Tyr Glu Ile Gln
                2165                2170                2175
Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala Cys Ser Gly Ala Asn
            2180                2185                2190
Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe Ser Arg Lys Val Gly
        2195                2200                2205
Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp Gly Asp Leu Asp Val
    2210                2215                2220
Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp Lys Thr Lys Ser Val
2225                2230                2235                2240
Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu Val Glu Asp Gly Ile
                2245                2250                2255
Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln Tyr Leu Phe Ser Trp
            2260                2265                2270
Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly Phe Asp Ser Glu Asn
        2275                2280                2285
Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu Ser Glu Arg Ser Gln
    2290                2295                2300
Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val Ala Leu Thr Cys Cys
2305                2310                2315                2320
Leu Leu Ala Leu Leu Leu Tyr Lys Lys Glu Arg Arg Glu Thr Val Ile
                2325                2330                2335
Ser Lys Leu Thr Thr Cys Cys Arg Arg Ser Ser Asn Val Ser Tyr Lys
            2340                2345                2350
Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp Glu Asn Glu Thr Glu
        2355                2360                2365
Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro Arg Gln Gly Lys Glu
    2370                2375                2380
Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser Val Lys Ala Leu Ser
2385                2390                2395                2400
Ser Leu His Gly Asp Asp Gln Asp Ser Glu Asp Glu Val Leu Thr Ile
                2405                2410                2415
Pro Glu Val Lys Val His Ser Gly Arg Gly Ala Gly Ala Glu Ser Ser
            2420                2425                2430
His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu Gln Glu Arg Glu Asp
        2435                2440                2445
Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala Arg Lys Gly Lys Ser
    2450                2455                2460
Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr Lys Leu Val Ser Phe
2465                2470                2475                2480
His Asp Asp Ser Asp Glu Asp Leu Leu His Ile
                2485                2490

<210> 986
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 986
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala
 1               5                  10                  15
Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val
            20                  25                  30
Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu
        35                  40                  45
Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr
    50                  55                  60
Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser
65                  70                  75                  80
Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val
                85                  90                  95
Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn
            100                 105                 110
Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser
        115                 120                 125
Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val
    130                 135                 140
Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala
145                 150                 155                 160
Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val
                165                 170                 175
Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu
            180                 185                 190
Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe
        195                 200                 205
Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln
    210                 215                 220
Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His
225                 230                 235                 240
Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg
                245                 250                 255
Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu
            260                 265                 270
Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys
        275                 280                 285
Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser
    290                 295                 300
Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg
305                 310                 315                 320
Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp
                325                 330                 335
Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr
            340                 345                 350
Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu
        355                 360                 365
Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val
    370                 375                 380
Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn
385                 390                 395                 400
Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly
                405                 410                 415
Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe
            420                 425                 430
Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe
        435                 440                 445
Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr
    450                 455                 460
Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly
465                 470                 475                 480
Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu
                485                 490                 495
Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys
            500                 505                 510
His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala
        515                 520                 525
Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly
    530                 535                 540
Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly
545                 550                 555                 560
Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys
                565                 570                 575
Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu
            580                 585                 590
Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu
        595                 600                 605
Phe Glu Trp Arg Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly
    610                 615                 620
Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu
625                 630                 635                 640
Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys
                645                 650                 655
Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys
            660                 665                 670
Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr
        675                 680                 685
Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met
    690                 695                 700
Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His
705                 710                 715                 720
Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly
                725                 730                 735
Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe
            740                 745                 750
Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val
        755                 760                 765
Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala
    770                 775                 780
Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser
785                 790                 795                 800
Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro
                805                 810                 815
Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met
            820                 825                 830
Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser
        835                 840                 845
Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser
    850                 855                 860
Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly
865                 870                 875                 880
Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly
                885                 890                 895
Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val
            900                 905                 910
Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr
        915                 920                 925
Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val
    930                 935                 940
Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly
945                 950                 955                 960
Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys
                965                 970                 975
Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln
            980                 985                 990
Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg Pro Val Gly Ile Glu
        995                 1000                1005
Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile Thr Leu Thr Tyr Lys
    1010                1015                1020
Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala Phe Ile Val Arg Phe
1025                1030                1035                1040
Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu Lys Phe Leu His Gln
                1045                1050                1055
Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr Tyr Phe Glu Phe Glu
            1060                1065                1070
Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp Cys Gln Val Thr Asp
        1075                1080                1085
Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu Ser Thr Val Arg Lys
    1090                1095                1100
Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly Arg Lys Arg Thr Phe
1105                1110                1115                1120
Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile Pro Gly Cys Gln Gly
                1125                1130                1135
Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly Asn Ser Trp Asn Leu
            1140                1145                1150
Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala Asn Gly Ser Leu Ser
        1155                1160                1165
Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn Gln Arg Phe Ser Thr
    1170                1175                1180
Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly Ser Pro Ala Phe Gln
1185                1190                1195                1200
Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp Arg Thr Val Glu Ala
                1205                1210                1215
Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys Glu Val Lys Asp Pro
            1220                1225                1230
Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu Gly Leu Asn Asp Thr
        1235                1240                1245
Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe Arg Val Cys Gly Lys
    1250                1255                1260
Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys Ser Lys Val Val Ser
1265                1270                1275                1280
Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe His Lys Val Ala Gly
                1285                1290                1295
Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly Leu Leu Lys Met Asn
            1300                1305                1310
Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr Gln Arg Ser Thr Ala
        1315                1320                1325
Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg Pro Val Phe Leu Lys
    1330                1335                1340
Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp Arg Thr Gln Tyr Ala
1345                1350                1355                1360
Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe Lys Asp Gly Ala Gly
                1365                1370                1375
Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr Ser Asp Asn Trp Glu
            1380                1385                1390
Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr Leu Ile Asn Val Cys
        1395                1400                1405
Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro Cys Pro Pro Glu Ala
    1410                1415                1420
Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val Asn Leu Gly Arg Val
1425                1430                1435                1440
Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile Val Leu Lys Tyr Val
                1445                1450                1455
Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys Lys Ser Thr Thr Ile
            1460                1465                1470
Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser Arg Pro Met Phe Ile
        1475                1480                1485
Ser Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala Trp Pro Thr Ala Thr
    1490                1495                1500
Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp Cys Gln Val Thr Asn
1505                1510                1515                1520
Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg Ala
                1525                1530                1535
Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu Val Tyr Met Ser Ile
            1540                1545                1550
Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val Gly Ala Cys Phe Gly
        1555                1560                1565
Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys Arg Leu Arg Tyr Val
    1570                1575                1580
Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly Ser Pro Cys Pro Ser
1585                1590                1595                1600
Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser Phe Val Cys Arg Pro
                1605                1610                1615
Glu Ala Gly Pro Thr Asn Arg Pro Met Leu Ile Ser Leu Asp Lys Gln
            1620                1625                1630
Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro Leu Ala Cys Glu Gln
        1635                1640                1645
Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser Ile Val Asp Leu Ser
    1650                1655                1660
Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala Tyr Asp Glu Ser Glu
1665                1670                1675                1680
Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr Ile Asn Ile Cys Gln
                1685                1690                1695
Pro Leu Asn Pro Met His Ala Val Pro Cys Pro Ala Gly Ala Ala Val
            1700                1705                1710
Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp Ile Gly Arg Val Ala
        1715                1720                1725
Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu Ile Tyr Leu Asn Phe
    1730                1735                1740
Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His Phe Asn Tyr Thr Ser
1745                1750                1755                1760
Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser Met Gly Thr Pro Lys
                1765                1770                1775
Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe Glu Trp Glu Thr Pro
            1780                1785                1790
Val Val Cys Pro Asp Glu Val Arg Met Asp Gly Cys Thr Leu Thr Asp
        1795                1800                1805
Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser Leu Ser Thr Ser Thr
    1810                1815                1820
Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser Val Gly Val Cys Thr
1825                1830                1835                1840
Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys Asp Gly Gly Val Cys
                1845                1850                1855
Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly Arg Leu Gln Ser Met
            1860                1865                1870
Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val Val Leu Ser Tyr Val
        1875                1880                1885
Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp Gly Val Pro Cys Val
    1890                1895                1900
Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu Glu Cys Ile Ile Glu
1905                1910                1915                1920
Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala Asp Tyr Asp Arg Asp
                1925                1930                1935
His Glu Trp Gly Phe Cys Arg His Ser Asn Ser Tyr Arg Thr Ser Ser
            1940                1945                1950
Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile Gly Arg Pro Gln Val
        1955                1960                1965
Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe Glu Trp Lys Thr Lys
    1970                1975                1980
Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys Phe Val Gln Lys His
1985                1990                1995                2000
Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu Thr Gly Ser Trp Ser
                2005                2010                2015
Leu Val His Asn Gly Val Ser Tyr Tyr Ile Asn Leu Cys Gln Lys Ile
            2020                2025                2030
Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala Ser Ile Cys Arg Arg
        2035                2040                2045
Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu Val His Thr Gln Lys
    2050                2055                2060
Leu Gly Val Ile Gly Asp Lys Val Val Val Thr Tyr Ser Lys Gly Tyr
2065                2070                2075                2080
Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val Ile Glu Leu Thr Cys
                2085                2090                2095
Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg Phe Asp Ile Asp Ser
            2100                2105                2110
Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala Ala Cys Ala Val Lys
        2115                2120                2125
Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile Thr Asn Pro Ile Asn
    2130                2135                2140
Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe Lys Leu Phe Arg Ala
2145                2150                2155                2160
Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr Leu Tyr Glu Ile Gln
                2165                2170                2175
Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala Cys Ser Gly Ala Asn
            2180                2185                2190
Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe Ser Arg Lys Val Gly
        2195                2200                2205
Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp Gly Asp Leu Asp Val
    2210                2215                2220
Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp Lys Thr Lys Ser Val
2225                2230                2235                2240
Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu Val Glu Asp Gly Ile
                2245                2250                2255
Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln Tyr Leu Phe Ser Trp
            2260                2265                2270
Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly Phe Asp Ser Glu Asn
        2275                2280                2285
Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu Ser Glu Arg Ser Gln
    2290                2295                2300
Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val Ala Leu Thr Cys Cys
2305                2310                2315                2320
Leu Leu Ala Leu Leu Leu Tyr Lys Lys Glu Arg Arg Glu Thr Val Ile
                2325                2330                2335
Ser Lys Leu Thr Thr Cys Cys Arg Arg Ser Ser Asn Val Ser Tyr Lys
            2340                2345                2350
Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp Glu Asn Glu Thr Glu
        2355                2360                2365
Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro Arg Gln Gly Lys Glu
    2370                2375                2380
Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser Val Lys Ala Leu Ser
2385                2390                2395                2400
Ser Leu His Gly Asp Asp Gln Asp Ser Glu Asp Glu Val Leu Thr Ile
                2405                2410                2415
Pro Glu Val Lys Val His Ser Gly Arg Gly Ala Gly Ala Glu Ser Ser
            2420                2425                2430
His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu Gln Glu Arg Glu Asp
        2435                2440                2445
Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala Arg Lys Gly Lys Ser
    2450                2455                2460
Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr Lys Leu Val Ser Phe
2465                2470                2475                2480
His Asp Asp Ser Asp Glu Asp Leu Leu His Ile
                2485                2490

<210> 987
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 987
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala
 1               5                  10                  15
Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val
            20                  25                  30
Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu
        35                  40                  45
Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr
    50                  55                  60
Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser
65                  70                  75                  80
Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val
                85                  90                  95
Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn
            100                 105                 110
Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser
        115                 120                 125
Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val
    130                 135                 140
Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala
145                 150                 155                 160
Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val
                165                 170                 175
Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu
            180                 185                 190
Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe
        195                 200                 205
Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln
    210                 215                 220
Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His
225                 230                 235                 240
Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg
                245                 250                 255
Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu
            260                 265                 270
Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys
        275                 280                 285
Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser
    290                 295                 300
Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg
305                 310                 315                 320
Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp
                325                 330                 335
Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr
            340                 345                 350
Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu
        355                 360                 365
Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val
    370                 375                 380
Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn
385                 390                 395                 400
Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly
                405                 410                 415
Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe
            420                 425                 430
Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe
        435                 440                 445
Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr
    450                 455                 460
Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly
465                 470                 475                 480
Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu
                485                 490                 495
Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys
            500                 505                 510
His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala
        515                 520                 525
Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly
    530                 535                 540
Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly
545                 550                 555                 560
Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys
                565                 570                 575
Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu
            580                 585                 590
Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu
        595                 600                 605
Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly
    610                 615                 620
Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu
625                 630                 635                 640
Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys
                645                 650                 655
Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys
            660                 665                 670
Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr
        675                 680                 685
Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met
    690                 695                 700
Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His
705                 710                 715                 720
Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly
                725                 730                 735
Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe
            740                 745                 750
Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val
        755                 760                 765
Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala
    770                 775                 780
Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser
785                 790                 795                 800
Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro
                805                 810                 815
Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met
            820                 825                 830
Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser
        835                 840                 845
Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser
    850                 855                 860
Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly
865                 870                 875                 880
Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly
                885                 890                 895
Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val
            900                 905                 910
Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr
        915                 920                 925
Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val
    930                 935                 940
Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly
945                 950                 955                 960
Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys
                965                 970                 975
Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln
            980                 985                 990
Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg Pro Val Gly Ile Glu
        995                 1000                1005
Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile Thr Leu Thr Tyr Lys
    1010                1015                1020
Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala Phe Ile Val Arg Phe
1025                1030                1035                1040
Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu Lys Phe Leu His Gln
                1045                1050                1055
Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr Tyr Phe Glu Phe Glu
            1060                1065                1070
Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp Cys Gln Val Thr Asp
        1075                1080                1085
Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu Ser Thr Val Arg Lys
    1090                1095                1100
Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly Arg Lys Arg Thr Phe
1105                1110                1115                1120
Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile Pro Gly Cys Gln Gly
                1125                1130                1135
Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly Asn Ser Trp Asn Leu
            1140                1145                1150
Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala Asn Gly Ser Leu Ser
        1155                1160                1165
Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn Gln Arg Phe Ser Thr
    1170                1175                1180
Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly Ser Pro Ala Phe Gln
1185                1190                1195                1200
Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp Arg Thr Val Glu Ala
                1205                1210                1215
Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys Glu Val Lys Asp Pro
            1220                1225                1230
Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu Gly Leu Asn Asp Thr
        1235                1240                1245
Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe Arg Val Cys Gly Lys
    1250                1255                1260
Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys Ser Lys Val Val Ser
1265                1270                1275                1280
Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe His Lys Val Ala Gly
                1285                1290                1295
Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly Leu Leu Lys Met Asn
            1300                1305                1310
Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr Gln Arg Ser Thr Ala
        1315                1320                1325
Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg Pro Val Phe Leu Lys
    1330                1335                1340
Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp Arg Thr Gln Tyr Ala
1345                1350                1355                1360
Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe Lys Asp Gly Ala Gly
                1365                1370                1375
Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr Ser Asp Asn Trp Glu
            1380                1385                1390
Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr Leu Ile Asn Val Cys
        1395                1400                1405
Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro Cys Pro Pro Glu Ala
    1410                1415                1420
Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val Asn Leu Gly Arg Val
1425                1430                1435                1440
Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile Val Leu Lys Tyr Val
                1445                1450                1455
Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys Lys Ser Thr Thr Ile
            1460                1465                1470
Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser Arg Pro Met Phe Ile
        1475                1480                1485
Ser Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala Trp Pro Thr Ala Thr
    1490                1495                1500
Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp Cys Gln Val Thr Asn
1505                1510                1515                1520
Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg Ala
                1525                1530                1535
Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu Val Tyr Met Ser Ile
            1540                1545                1550
Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val Gly Ala Cys Phe Gly
        1555                1560                1565
Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys Arg Leu Arg Tyr Val
    1570                1575                1580
Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly Ser Pro Cys Pro Ser
1585                1590                1595                1600
Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser Phe Val Cys Arg Pro
                1605                1610                1615
Glu Ala Arg Pro Thr Asn Arg Pro Met Leu Ile Ser Leu Asp Lys Gln
            1620                1625                1630
Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro Leu Ala Cys Glu Gln
        1635                1640                1645
Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser Ile Val Asp Leu Ser
    1650                1655                1660
Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala Tyr Asp Glu Ser Glu
1665                1670                1675                1680
Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr Ile Asn Ile Cys Gln
                1685                1690                1695
Pro Leu Asn Pro Met His Gly Val Pro Cys Pro Ala Gly Ala Ala Val
            1700                1705                1710
Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp Ile Gly Arg Val Ala
        1715                1720                1725
Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu Ile Tyr Leu Asn Phe
    1730                1735                1740
Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His Phe Asn Tyr Thr Ser
1745                1750                1755                1760
Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser Met Gly Thr Pro Lys
                1765                1770                1775
Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe Glu Trp Glu Thr Pro
            1780                1785                1790
Val Val Cys Pro Asp Glu Val Arg Met Asp Gly Cys Thr Leu Thr Asp
        1795                1800                1805
Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser Leu Ser Thr Ser Thr
    1810                1815                1820
Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser Val Gly Val Cys Thr
1825                1830                1835                1840
Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys Asp Gly Gly Val Cys
                1845                1850                1855
Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly Arg Leu Gln Ser Met
            1860                1865                1870
Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val Val Leu Ser Tyr Val
        1875                1880                1885
Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp Gly Val Pro Cys Val
    1890                1895                1900
Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu Glu Cys Ile Ile Glu
1905                1910                1915                1920
Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala Asp Tyr Asp Arg Asp
                1925                1930                1935
His Glu Trp Gly Phe Cys Arg His Ser Asn Ser Tyr Arg Thr Ser Ser
            1940                1945                1950
Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile Gly Arg Pro Gln Val
        1955                1960                1965
Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe Glu Trp Lys Thr Lys
    1970                1975                1980
Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys Phe Val Gln Lys His
1985                1990                1995                2000
Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu Thr Gly Ser Trp Ser
                2005                2010                2015
Leu Val His Asn Gly Val Ser Tyr Tyr Ile Asn Leu Cys Gln Lys Ile
            2020                2025                2030
Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala Ser Ile Cys Arg Arg
        2035                2040                2045
Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu Val His Thr Gln Lys
    2050                2055                2060
Leu Gly Val Ile Gly Asp Lys Val Val Val Thr Tyr Ser Lys Gly Tyr
2065                2070                2075                2080
Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val Ile Glu Leu Thr Cys
                2085                2090                2095
Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg Phe Asp Ile Asp Ser
            2100                2105                2110
Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala Ala Cys Ala Val Lys
        2115                2120                2125
Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile Thr Asn Pro Ile Asn
    2130                2135                2140
Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe Lys Leu Phe Arg Ala
2145                2150                2155                2160
Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr Leu Tyr Glu Ile Gln
                2165                2170                2175
Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala Cys Ser Gly Ala Asn
            2180                2185                2190
Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe Ser Arg Lys Val Gly
        2195                2200                2205
Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp Gly Asp Leu Asp Val
    2210                2215                2220
Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp Lys Thr Lys Ser Val
2225                2230                2235                2240
Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu Val Glu Asp Gly Ile
                2245                2250                2255
Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln Tyr Leu Phe Ser Trp
            2260                2265                2270
Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly Phe Asp Ser Glu Asn
        2275                2280                2285
Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu Ser Glu Arg Ser Gln
    2290                2295                2300
Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val Ala Leu Thr Cys Cys
2305                2310                2315                2320
Leu Leu Ala Leu Leu Leu Tyr Lys Lys Glu Arg Arg Glu Thr Val Ile
                2325                2330                2335
Ser Lys Leu Thr Thr Cys Cys Arg Arg Ser Ser Asn Val Ser Tyr Lys
            2340                2345                2350
Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp Glu Asn Glu Thr Glu
        2355                2360                2365
Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro Arg Gln Gly Lys Glu
    2370                2375                2380
Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser Val Lys Ala Leu Ser
2385                2390                2395                2400
Ser Leu His Gly Asp Asp Gln Asp Ser Glu Asp Glu Val Leu Thr Ile
                2405                2410                2415
Pro Glu Val Lys Val His Ser Gly Arg Gly Ala Gly Ala Glu Ser Ser
            2420                2425                2430
His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu Gln Glu Arg Glu Asp
        2435                2440                2445
Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala Arg Lys Gly Lys Ser
    2450                2455                2460
Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr Lys Leu Val Ser Phe
2465                2470                2475                2480
His Asp Asp Ser Asp Glu Asp Leu Leu His Ile
                2485                2490

<210> 988
<211> 255
<212> PRT
<213> Homo sapiens

<400> 988
Met Asp Ile Thr Asp Ile Asn Ala Pro Lys Pro Lys Lys Lys Gln Arg
 1               5                  10                  15
Trp Thr Pro Leu Glu Ile Ser Leu Ser Val Leu Val Leu Leu Leu Thr
            20                  25                  30
Ile Ile Ala Val Thr Met Ile Ala Leu Tyr Ala Thr Tyr Asp Asp Gly
        35                  40                  45
Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Val Phe Pro Ala Gly Ile
    50                  55                  60
Leu Gln Pro Pro Phe Phe Ser Ala Arg Gln Ser Asn Ser Leu Asn Tyr
65                  70                  75                  80
Gly Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp
                85                  90                  95
Asp Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp
            100                 105                 110
Thr Gln Gln Ser Ala Asn Asn Phe Lys Asp Gln Ser Gln Cys Met Val
        115                 120                 125
Tyr Gln Tyr Gly Asn Phe Thr Trp Asp Leu Ala Gly Gly Gln His Leu
    130                 135                 140
Asn Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Ile
145                 150                 155                 160
Gly Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Val Lys Lys Asn Gly Glu
                165                 170                 175
Glu Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe
            180                 185                 190
Leu Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala
        195                 200                 205
Val Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile
    210                 215                 220
Ile Gly Thr Leu Gln Asn Ser Ala Glu Phe Ala Asp Ala Phe His Cys
225                 230                 235                 240
Arg Lys Asn Ser Tyr Met Asn Pro Glu Arg Lys Cys Arg Val Trp
                245                 250                 255

<210> 989
<211> 750
<212> PRT
<213> Homo sapiens

<400> 989
Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro
 1               5                  10                  15
Lys Pro Lys Lys Lys Gln Arg Trp Thr Arg Leu Glu Ile Ser Leu Ser
            20                  25                  30
Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Arg Met Ile Ala Leu
        35                  40                  45
Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys
    50                  55                  60
Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys
65                  70                  75                  80
Arg Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val
                85                  90                  95
Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp
            100                 105                 110
Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu
        115                 120                 125
Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile
    130                 135                 140
Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu
145                 150                 155                 160
Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln
                165                 170                 175
Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn
            180                 185                 190
Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp
        195                 200                 205
Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu
    210                 215                 220
Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu
225                 230                 235                 240
Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile
                245                 250                 255
Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu
            260                 265                 270
Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala
        275                 280                 285
Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Arg
    290                 295                 300
Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro
305                 310                 315                 320
Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile
                325                 330                 335
Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu
            340                 345                 350
Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln
        355                 360                 365
Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser
    370                 375                 380
Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly
385                 390                 395                 400
Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn
                405                 410                 415
Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe
            420                 425                 430
Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg
        435                 440                 445
Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu
    450                 455                 460
Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile
465                 470                 475                 480
Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu
                485                 490                 495
Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile
            500                 505                 510
Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu
        515                 520                 525
Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala
    530                 535                 540
Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu
545                 550                 555                 560
Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly
                565                 570                 575
Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp
            580                 585                 590
Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr
        595                 600                 605
Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr
    610                 615                 620
Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn
625                 630                 635                 640
Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly
                645                 650                 655
Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu
            660                 665                 670
Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu
        675                 680                 685
Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val
    690                 695                 700
Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile
705                 710                 715                 720
Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg
                725                 730                 735
Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745                 750

<210> 990
<211> 750
<212> PRT
<213> Homo sapiens

<400> 990
Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro
 1               5                  10                  15
Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser
            20                  25                  30
Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu
        35                  40                  45
Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys
    50                  55                  60
Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys
65                  70                  75                  80
Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val
                85                  90                  95
Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp
            100                 105                 110
Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu
        115                 120                 125
Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile
    130                 135                 140
Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu
145                 150                 155                 160
Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln
                165                 170                 175
Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn
            180                 185                 190
Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp
        195                 200                 205
Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu
    210                 215                 220
Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu
225                 230                 235                 240
Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile
                245                 250                 255
Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu
            260                 265                 270
Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala
        275                 280                 285
Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr
    290                 295                 300
Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro
305                 310                 315                 320
Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile
                325                 330                 335
Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu
            340                 345                 350
Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln
        355                 360                 365
Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser
    370                 375                 380
Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly
385                 390                 395                 400
Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn
                405                 410                 415
Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe
            420                 425                 430
Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg
        435                 440                 445
Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu
    450                 455                 460
Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile
465                 470                 475                 480
Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu
                485                 490                 495
Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile
            500                 505                 510
Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu
        515                 520                 525
Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala
    530                 535                 540
Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu
545                 550                 555                 560
Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly
                565                 570                 575
Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp
            580                 585                 590
Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr
        595                 600                 605
Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr
    610                 615                 620
Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn
625                 630                 635                 640
Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly
                645                 650                 655
Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu
            660                 665                 670
Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu
        675                 680                 685
Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val
    690                 695                 700
Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile
705                 710                 715                 720
Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg
                725                 730                 735
Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745                 750

<210> 991
<211> 750
<212> PRT
<213> Homo sapiens

<400> 991
Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro
 1               5                  10                  15
Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser
            20                  25                  30
Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu
        35                  40                  45
Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys
    50                  55                  60
Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys
65                  70                  75                  80
Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val
                85                  90                  95
Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp
            100                 105                 110
Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu
        115                 120                 125
Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile
    130                 135                 140
Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu
145                 150                 155                 160
Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln
                165                 170                 175
Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn
            180                 185                 190
Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp
        195                 200                 205
Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu
    210                 215                 220
Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu
225                 230                 235                 240
Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile
                245                 250                 255
Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu
            260                 265                 270
Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala
        275                 280                 285
Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr
    290                 295                 300
Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro
305                 310                 315                 320
Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile
                325                 330                 335
Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu
            340                 345                 350
Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln
        355                 360                 365
Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser
    370                 375                 380
Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly
385                 390                 395                 400
Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn
                405                 410                 415
Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe
            420                 425                 430
Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg
        435                 440                 445
Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu
    450                 455                 460
Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile
465                 470                 475                 480
Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu
                485                 490                 495
Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile
            500                 505                 510
Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu
        515                 520                 525
Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala
    530                 535                 540
Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu
545                 550                 555                 560
Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly
                565                 570                 575
Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp
            580                 585                 590
Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr
        595                 600                 605
Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr
    610                 615                 620
Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn
625                 630                 635                 640
Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly
                645                 650                 655
Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu
            660                 665                 670
Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu
        675                 680                 685
Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val
    690                 695                 700
Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile
705                 710                 715                 720
Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg
                725                 730                 735
Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745                 750

<210> 992
<211> 743
<212> PRT
<213> Homo sapiens

<400> 992
Met Asp Ile Thr Asp Ile Asn Thr Pro Lys Pro Lys Lys Lys Gln Arg
 1               5                  10                  15
Trp Thr Pro Leu Glu Ile Ser Leu Ser Val Leu Val Leu Leu Leu Thr
            20                  25                  30
Ile Ile Ala Val Thr Met Ile Ala Leu Tyr Ala Thr Tyr Asp Asp Gly
        35                  40                  45
Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala Arg Leu Ile Gln
    50                  55                  60
Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe Phe Lys Tyr Ala
65                  70                  75                  80
Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu Thr Ser Ser Arg
                85                  90                  95
Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu Val Val Leu Lys
            100                 105                 110
Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val Ala Val Gln Lys
        115                 120                 125
Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser Ala Ile Asp Ser
    130                 135                 140
Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp Ile Tyr Gly Trp
145                 150                 155                 160
Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly Ala Ser Trp Thr
                165                 170                 175
Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr Gly Lys Lys Val
            180                 185                 190
Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn Ser Val Asn His
        195                 200                 205
Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro Ser Arg Asp Tyr
    210                 215                 220
Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr Ala Tyr Val Asp
225                 230                 235                 240
Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu Glu Arg Leu Pro
                245                 250                 255
Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys Val Met Glu Leu
            260                 265                 270
Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu Asp Arg Asn Asp
        275                 280                 285
Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln Ile Gln Asn Asn
    290                 295                 300
Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp Leu Asn Phe Thr
305                 310                 315                 320
Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr Asn Glu Glu Asp
                325                 330                 335
Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu Lys Pro Ile Leu
            340                 345                 350
Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met Ser Trp Arg Phe
        355                 360                 365
Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr Lys Glu Ser Arg
    370                 375                 380
Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr Ser Glu Thr Ala Thr
385                 390                 395                 400
Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met Glu Asn Ala Val
                405                 410                 415
Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu Ser Lys His Val
            420                 425                 430
Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe Ile Gln Thr Leu
        435                 440                 445
Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys Lys Arg Ala Glu Glu
    450                 455                 460
Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr Pro Asp Asp Ile Val
465                 470                 475                 480
Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu Glu Leu Asn Tyr Lys
                485                 490                 495
Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn Leu Lys Phe Ser Gln
            500                 505                 510
Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val Asp Lys Asp Glu Trp
        515                 520                 525
Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr Ser Ser Gly Arg Asn
    530                 535                 540
Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro Phe Phe Ser Ala
545                 550                 555                 560
Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly Met Val Ile Gly
                565                 570                 575
His Glu Ile Thr His Gly Phe Asp Asp Asn Gly Arg Asn Phe Asn Lys
            580                 585                 590
Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln Ser Ala Ser Asn Phe
        595                 600                 605
Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr Gly Asn Phe Ser Trp
    610                 615                 620
Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile Asn Thr Leu Gly Glu
625                 630                 635                 640
Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala Tyr Arg Ala Tyr Gln
                645                 650                 655
Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu Leu Pro Gly Leu Asp
            660                 665                 670
Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe Ala Gln Val Trp Cys
        675                 680                 685
Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser Ile Lys Thr Asp Val
    690                 695                 700
His Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr Leu Gln Asn Ser Ala
705                 710                 715                 720
Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn Ser Tyr Met Asn Pro
                725                 730                 735
Glu Lys Lys Cys Arg Val Trp
            740

<210> 993
<211> 743
<212> PRT
<213> Homo sapiens

<400> 993
Met Asp Ile Thr Asp Ile Asn Thr Pro Lys Pro Lys Lys Lys Gln Arg
 1               5                  10                  15
Trp Thr Pro Leu Glu Ile Ser Leu Ser Val Leu Val Leu Leu Leu Thr
            20                  25                  30
Ile Ile Ala Val Thr Met Ile Ala Leu Tyr Ala Thr Tyr Asp Asp Gly
        35                  40                  45
Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala Arg Leu Ile Gln
    50                  55                  60
Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe Phe Lys Tyr Ala
65                  70                  75                  80
Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu Thr Ser Ser Arg
                85                  90                  95
Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu Val Val Leu Lys
            100                 105                 110
Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val Ala Val Gln Lys
        115                 120                 125
Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser Ala Ile Asp Ser
    130                 135                 140
Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp Ile Tyr Gly Trp
145                 150                 155                 160
Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly Ala Ser Trp Thr
                165                 170                 175
Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr Gly Lys Lys Val
            180                 185                 190
Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn Ser Val Asn His
        195                 200                 205
Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro Ser Arg Asp Tyr
    210                 215                 220
Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr Ala Tyr Val Asp
225                 230                 235                 240
Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu Glu Arg Leu Pro
                245                 250                 255
Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys Val Met Glu Leu
            260                 265                 270
Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu Asp Arg Asn Asp
        275                 280                 285
Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln Ile Gln Asn Asn
    290                 295                 300
Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp Leu Asn Phe Thr
305                 310                 315                 320
Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr Asn Glu Glu Asp
                325                 330                 335
Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu Lys Pro Ile Leu
            340                 345                 350
Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met Ser Trp Arg Phe
        355                 360                 365
Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr Lys Glu Ser Arg
    370                 375                 380
Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr Ser Glu Thr Ala Thr
385                 390                 395                 400
Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met Glu Asn Ala Val
                405                 410                 415
Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu Ser Lys His Val
            420                 425                 430
Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe Ile Gln Thr Leu
        435                 440                 445
Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys Lys Arg Ala Glu Glu
    450                 455                 460
Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr Pro Asp Asp Ile Val
465                 470                 475                 480
Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu Glu Leu Asn Tyr Lys
                485                 490                 495
Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn Leu Lys Phe Ser Gln
            500                 505                 510
Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val Asp Lys Asp Glu Trp
        515                 520                 525
Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr Ser Ser Gly Arg Asn
    530                 535                 540
Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro Phe Phe Ser Ala
545                 550                 555                 560
Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly Met Val Ile Gly
                565                 570                 575
His Glu Ile Thr His Gly Phe Asp Asp Asn Gly Arg Asn Phe Asn Lys
            580                 585                 590
Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln Ser Ala Ser Asn Phe
        595                 600                 605
Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr Gly Asn Phe Ser Trp
    610                 615                 620
Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile Asn Thr Leu Gly Glu
625                 630                 635                 640
Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala Tyr Arg Ala Tyr Gln
                645                 650                 655
Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu Leu Pro Gly Leu Asp
            660                 665                 670
Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe Ala Gln Val Trp Cys
        675                 680                 685
Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser Ile Lys Thr Asp Val
    690                 695                 700
His Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr Leu Gln Asn Ser Ala
705                 710                 715                 720
Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn Ser Tyr Met Asn Pro
                725                 730                 735
Glu Lys Lys Cys Arg Val Trp
            740

<210> 994
<211> 743
<212> PRT
<213> Homo sapiens

<400> 994
Met Asp Ile Thr Asp Ile Asn Thr Pro Lys Pro Lys Lys Lys Gln Arg
 1               5                  10                  15
Trp Thr Pro Leu Glu Ile Ser Leu Ser Val Leu Val Leu Leu Leu Thr
            20                  25                  30
Ile Ile Ala Val Thr Met Ile Ala Leu Tyr Ala Thr Tyr Asp Asp Gly
        35                  40                  45
Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala Arg Leu Ile Gln
    50                  55                  60
Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe Phe Lys Tyr Ala
65                  70                  75                  80
Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu Thr Ser Ser Arg
                85                  90                  95
Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu Val Val Leu Lys
            100                 105                 110
Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val Ala Val Gln Lys
        115                 120                 125
Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser Ala Ile Asp Ser
    130                 135                 140
Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp Ile Tyr Gly Trp
145                 150                 155                 160
Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly Ala Ser Trp Thr
                165                 170                 175
Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr Gly Lys Lys Val
            180                 185                 190
Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn Ser Val Asn His
        195                 200                 205
Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro Ser Arg Asp Tyr
    210                 215                 220
Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr Ala Tyr Val Asp
225                 230                 235                 240
Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu Glu Arg Leu Pro
                245                 250                 255
Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys Val Met Glu Leu
            260                 265                 270
Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu Asp Arg Asn Asp
        275                 280                 285
Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln Ile Gln Asn Asn
    290                 295                 300
Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp Leu Asn Phe Thr
305                 310                 315                 320
Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr Asn Glu Glu Asp
                325                 330                 335
Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu Lys Pro Ile Leu
            340                 345                 350
Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met Ser Trp Arg Phe
        355                 360                 365
Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr Lys Glu Ser Arg
    370                 375                 380
Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr Ser Glu Thr Ala Thr
385                 390                 395                 400
Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met Glu Asn Ala Val
                405                 410                 415
Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu Ser Lys His Val
            420                 425                 430
Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe Ile Gln Thr Leu
        435                 440                 445
Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys Lys Arg Ala Glu Glu
    450                 455                 460
Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr Pro Asp Asp Ile Val
465                 470                 475                 480
Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu Glu Leu Asn Tyr Lys
                485                 490                 495
Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn Leu Lys Phe Ser Gln
            500                 505                 510
Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val Asp Lys Asp Glu Trp
        515                 520                 525
Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr Ser Ser Gly Arg Asn
    530                 535                 540
Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro Phe Phe Ser Ala
545                 550                 555                 560
Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly Met Val Ile Gly
                565                 570                 575
His Glu Ile Thr His Gly Phe Asp Asp Asn Gly Arg Asn Phe Asn Lys
            580                 585                 590
Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln Ser Ala Ser Asn Phe
        595                 600                 605
Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr Gly Asn Phe Ser Trp
    610                 615                 620
Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile Asn Thr Leu Gly Glu
625                 630                 635                 640
Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala Tyr Arg Ala Tyr Gln
                645                 650                 655
Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu Leu Pro Gly Leu Asp
            660                 665                 670
Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe Ala Gln Val Trp Cys
        675                 680                 685
Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser Ile Lys Thr Asp Val
    690                 695                 700
His Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr Leu Gln Asn Ser Ala
705                 710                 715                 720
Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn Ser Tyr Met Asn Pro
                725                 730                 735
Glu Lys Lys Cys Arg Val Trp
            740

<210> 995
<211> 743
<212> PRT
<213> Homo sapiens

<400> 995
Met Asp Ile Thr Asp Ile Asn Thr Pro Lys Pro Lys Lys Lys Gln Arg
 1               5                  10                  15
Trp Thr Pro Leu Glu Ile Ser Leu Ser Val Leu Val Leu Leu Leu Thr
            20                  25                  30
Ile Ile Ala Val Thr Met Ile Ala Leu Tyr Ala Thr Tyr Asp Asp Gly
        35                  40                  45
Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala Arg Leu Ile Gln
    50                  55                  60
Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe Phe Lys Tyr Ala
65                  70                  75                  80
Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu Thr Ser Ser Arg
                85                  90                  95
Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu Val Val Leu Lys
            100                 105                 110
Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val Ala Val Gln Lys
        115                 120                 125
Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser Ala Ile Asp Ser
    130                 135                 140
Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp Ile Tyr Gly Trp
145                 150                 155                 160
Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly Ala Ser Trp Thr
                165                 170                 175
Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr Gly Lys Lys Val
            180                 185                 190
Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn Ser Val Asn His
        195                 200                 205
Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro Ser Arg Asp Tyr
    210                 215                 220
Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr Ala Tyr Val Asp
225                 230                 235                 240
Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu Glu Arg Leu Pro
                245                 250                 255
Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys Val Met Glu Leu
            260                 265                 270
Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu Asp Arg Asn Asp
        275                 280                 285
Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln Ile Gln Asn Asn
    290                 295                 300
Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp Leu Asn Phe Thr
305                 310                 315                 320
Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr Asn Glu Glu Asp
                325                 330                 335
Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu Lys Pro Ile Leu
            340                 345                 350
Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met Ser Trp Arg Phe
        355                 360                 365
Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr Lys Glu Ser Arg
    370                 375                 380
Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr Ser Glu Thr Ala Thr
385                 390                 395                 400
Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met Glu Asn Ala Val
                405                 410                 415
Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu Ser Lys His Val
            420                 425                 430
Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe Ile Gln Thr Leu
        435                 440                 445
Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys Lys Arg Ala Glu Glu
    450                 455                 460
Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr Pro Asp Asp Ile Val
465                 470                 475                 480
Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu Glu Leu Asn Tyr Lys
                485                 490                 495
Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn Leu Lys Phe Ser Gln
            500                 505                 510
Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val Asp Lys Asp Glu Trp
        515                 520                 525
Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr Ser Ser Gly Arg Asn
    530                 535                 540
Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro Phe Phe Ser Ala
545                 550                 555                 560
Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly Met Val Ile Gly
                565                 570                 575
His Glu Ile Thr His Gly Phe Asp Asp Asn Gly Arg Asn Phe Asn Lys
            580                 585                 590
Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln Ser Ala Ser Asn Phe
        595                 600                 605
Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr Gly Asn Phe Ser Trp
    610                 615                 620
Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile Asn Thr Leu Gly Glu
625                 630                 635                 640
Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala Tyr Arg Ala Tyr Gln
                645                 650                 655
Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu Leu Pro Gly Leu Asp
            660                 665                 670
Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe Ala Gln Val Trp Cys
        675                 680                 685
Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser Ile Lys Thr Asp Val
    690                 695                 700
His Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr Leu Gln Asn Ser Ala
705                 710                 715                 720
Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn Ser Tyr Met Asn Pro
                725                 730                 735
Glu Lys Lys Cys Arg Val Trp
            740

<210> 996
<211> 743
<212> PRT
<213> Homo sapiens

<400> 996
Met Asp Ile Thr Asp Ile Asn Thr Pro Lys Pro Lys Lys Lys Gln Arg
 1               5                  10                  15
Trp Thr Pro Leu Glu Ile Ser Leu Ser Val Leu Val Leu Leu Leu Thr
            20                  25                  30
Ile Ile Ala Val Thr Met Ile Ala Leu Tyr Ala Thr Tyr Asp Asp Gly
        35                  40                  45
Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala Arg Leu Ile Gln
    50                  55                  60
Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe Phe Lys Tyr Ala
65                  70                  75                  80
Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu Thr Ser Ser Arg
                85                  90                  95
Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu Val Val Leu Lys
            100                 105                 110
Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val Ala Val Gln Lys
        115                 120                 125
Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser Ala Ile Asp Ser
    130                 135                 140
Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp Ile Tyr Gly Trp
145                 150                 155                 160
Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly Ala Ser Trp Thr
                165                 170                 175
Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr Gly Lys Lys Val
            180                 185                 190
Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn Ser Val Asn His
        195                 200                 205
Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro Ser Arg Asp Tyr
    210                 215                 220
Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr Ala Tyr Val Asp
225                 230                 235                 240
Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu Glu Arg Leu Pro
                245                 250                 255
Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys Val Met Glu Leu
            260                 265                 270
Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu Asp Arg Asn Asp
        275                 280                 285
Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln Ile Gln Asn Asn
    290                 295                 300
Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp Leu Asn Phe Thr
305                 310                 315                 320
Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr Asn Glu Glu Asp
                325                 330                 335
Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu Lys Pro Ile Leu
            340                 345                 350
Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met Ser Trp Arg Phe
        355                 360                 365
Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr Lys Glu Ser Arg
    370                 375                 380
Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr Ser Glu Thr Ala Thr
385                 390                 395                 400
Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met Glu Asn Ala Val
                405                 410                 415
Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu Ser Lys His Val
            420                 425                 430
Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe Ile Gln Thr Leu
        435                 440                 445
Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys Lys Arg Ala Glu Glu
    450                 455                 460
Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr Pro Asp Asp Ile Val
465                 470                 475                 480
Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu Glu Leu Asn Tyr Lys
                485                 490                 495
Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn Leu Lys Phe Ser Gln
            500                 505                 510
Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val Asp Lys Asp Glu Trp
        515                 520                 525
Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr Ser Ser Gly Arg Asn
    530                 535                 540
Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro Phe Phe Ser Ala
545                 550                 555                 560
Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly Met Val Ile Gly
                565                 570                 575
His Glu Ile Thr His Gly Phe Asp Asp Asn Gly Arg Asn Phe Asn Lys
            580                 585                 590
Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln Ser Ala Ser Asn Phe
        595                 600                 605
Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr Gly Asn Phe Ser Trp
    610                 615                 620
Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile Asn Thr Leu Gly Glu
625                 630                 635                 640
Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala Tyr Arg Ala Tyr Gln
                645                 650                 655
Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu Leu Pro Gly Leu Asp
            660                 665                 670
Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe Ala Gln Val Trp Cys
        675                 680                 685
Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser Ile Lys Thr Asp Val
    690                 695                 700
His Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr Leu Gln Asn Ser Ala
705                 710                 715                 720
Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn Ser Tyr Met Asn Pro
                725                 730                 735
Glu Lys Lys Cys Arg Val Trp
            740

<210> 997
<211> 133
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(133)
<223> Xaa = Any Amino Acid

<400> 997
Met Asp Ala Glu Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile
 1               5                  10                  15
Lys Glu Arg Ile Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys
            20                  25                  30
Leu Xaa Asn Xaa Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe
        35                  40                  45
Glu Asn Ile Ile Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys
    50                  55                  60
Lys Leu Arg Glu Lys Xaa Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala
65                  70                  75                  80
Val Val Asn Ala Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro
                85                  90                  95
Ala Gly Ile Leu Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser
            100                 105                 110
Leu Asn Tyr Gly Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His
        115                 120                 125
Gly Phe Asp Asp Asn
    130

<210> 998
<211> 748
<212> PRT
<213> Homo sapiens

<400> 998
Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro Lys Pro
 1               5                  10                  15
Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser Val Leu
            20                  25                  30
Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu Tyr Ala
        35                  40                  45
Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala
    50                  55                  60
Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp
65                  70                  75                  80
Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro
                85                  90                  95
Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu
            100                 105                 110
Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile
        115                 120                 125
Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu
    130                 135                 140
Ser Ala Ile Asp Thr Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro
145                 150                 155                 160
Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr
                165                 170                 175
Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys
            180                 185                 190
Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys
        195                 200                 205
Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu
    210                 215                 220
Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys
225                 230                 235                 240
Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln
                245                 250                 255
Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn
            260                 265                 270
Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro
        275                 280                 285
Glu Asp Gln Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala
    290                 295                 300
Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser
305                 310                 315                 320
Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile
                325                 330                 335
Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys
            340                 345                 350
Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu
        355                 360                 365
Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr
    370                 375                 380
Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr
385                 390                 395                 400
Ser Glu Thr Ala Thr Trp Arg Arg Ser Ala Asn Tyr Val Asn Gly Asn
                405                 410                 415
Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly
            420                 425                 430
Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val
        435                 440                 445
Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys
    450                 455                 460
Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr
465                 470                 475                 480
Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu
                485                 490                 495
Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn
            500                 505                 510
Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val
        515                 520                 525
Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr
    530                 535                 540
Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro
545                 550                 555                 560
Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile
                565                 570                 575
Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn Gly
            580                 585                 590
Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln
        595                 600                 605
Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr
    610                 615                 620
Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile
625                 630                 635                 640
Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala
                645                 650                 655
Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu
            660                 665                 670
Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe
        675                 680                 685
Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser
    690                 695                 700
Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr
705                 710                 715                 720
Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn
                725                 730                 735
Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745

<210> 999
<211> 750
<212> PRT
<213> Homo sapiens

<400> 999
Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro
 1               5                  10                  15
Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser
            20                  25                  30
Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu
        35                  40                  45
Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys
    50                  55                  60
Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys
65                  70                  75                  80
Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val
                85                  90                  95
Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp
            100                 105                 110
Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu
        115                 120                 125
Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile
    130                 135                 140
Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu
145                 150                 155                 160
Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln
                165                 170                 175
Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Ile
            180                 185                 190
Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp
        195                 200                 205
Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu
    210                 215                 220
Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu
225                 230                 235                 240
Ala Cys Thr Ala Tyr Val His Phe Met Ile Ser Val Ala Arg Leu Ile
                245                 250                 255
Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu
            260                 265                 270
Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala
        275                 280                 285
Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr
    290                 295                 300
Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro
305                 310                 315                 320
Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile
                325                 330                 335
Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu
            340                 345                 350
Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln
        355                 360                 365
Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser
    370                 375                 380
Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly
385                 390                 395                 400
Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn
                405                 410                 415
Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Tyr
            420                 425                 430
Gly Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg
        435                 440                 445
Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu
    450                 455                 460
Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile
465                 470                 475                 480
Gly Tyr Pro Asp Asp Ile Leu Ser Asn Asp Asn Lys Leu Asn Asn Glu
                485                 490                 495
Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile
            500                 505                 510
Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu
        515                 520                 525
Lys Val Asp Lys Asp Glu Trp Ile Ser Ala Ala Ala Val Val Asn Ala
    530                 535                 540
Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu
545                 550                 555                 560
Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly
                565                 570                 575
Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp
            580                 585                 590
Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr
        595                 600                 605
Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr
    610                 615                 620
Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn
625                 630                 635                 640
Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly
                645                 650                 655
Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu
            660                 665                 670
Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu
        675                 680                 685
Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val
    690                 695                 700
Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile
705                 710                 715                 720
Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg
                725                 730                 735
Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745                 750

<210> 1000
<211> 748
<212> PRT
<213> Homo sapiens

<400> 1000
Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro Lys Pro
 1               5                  10                  15
Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser Val Leu
            20                  25                  30
Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu Tyr Ala
        35                  40                  45
Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala
    50                  55                  60
Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp
65                  70                  75                  80
Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro
                85                  90                  95
Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu
            100                 105                 110
Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile
        115                 120                 125
Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu
    130                 135                 140
Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro
145                 150                 155                 160
Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr
                165                 170                 175
Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys
            180                 185                 190
Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys
        195                 200                 205
Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu
    210                 215                 220
Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys
225                 230                 235                 240
Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln
                245                 250                 255
Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn
            260                 265                 270
Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro
        275                 280                 285
Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala
    290                 295                 300
Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser
305                 310                 315                 320
Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile
                325                 330                 335
Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys
            340                 345                 350
Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu
        355                 360                 365
Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr
    370                 375                 380
Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr
385                 390                 395                 400
Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn
                405                 410                 415
Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly
            420                 425                 430
Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val
        435                 440                 445
Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys
    450                 455                 460
Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr
465                 470                 475                 480
Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu
                485                 490                 495
Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn
            500                 505                 510
Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val
        515                 520                 525
Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr
    530                 535                 540
Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro
545                 550                 555                 560
Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile
                565                 570                 575
Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn Gly
            580                 585                 590
Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln
        595                 600                 605
Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr
    610                 615                 620
Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile
625                 630                 635                 640
Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala
                645                 650                 655
Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu
            660                 665                 670
Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe
        675                 680                 685
Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser
    690                 695                 700
Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr
705                 710                 715                 720
Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn
                725                 730                 735
Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745

<210> 1001
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1001
Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro
 1               5                  10                  15
Lys Pro Lys Lys Lys Gln Arg Trp Thr Arg Leu Glu Ile Ser Leu Ser
            20                  25                  30
Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Arg Met Ile Ala Leu
        35                  40                  45
Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys
    50                  55                  60
Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys
65                  70                  75                  80
Arg Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val
                85                  90                  95
Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp
            100                 105                 110
Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu
        115                 120                 125
Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile
    130                 135                 140
Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu
145                 150                 155                 160
Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln
                165                 170                 175
Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn
            180                 185                 190
Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp
        195                 200                 205
Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu
    210                 215                 220
Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu
225                 230                 235                 240
Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile
                245                 250                 255
Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu
            260                 265                 270
Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala
        275                 280                 285
Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Arg
    290                 295                 300
Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro
305                 310                 315                 320
Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile
                325                 330                 335
Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu
            340                 345                 350
Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln
        355                 360                 365
Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser
    370                 375                 380
Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly
385                 390                 395                 400
Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn
                405                 410                 415
Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe
            420                 425                 430
Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg
        435                 440                 445
Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu
    450                 455                 460
Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile
465                 470                 475                 480
Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu
                485                 490                 495
Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile
            500                 505                 510
Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu
        515                 520                 525
Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala
    530                 535                 540
Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu
545                 550                 555                 560
Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly
                565                 570                 575
Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp
            580                 585                 590
Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr
        595                 600                 605
Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr
    610                 615                 620
Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn
625                 630                 635                 640
Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly
                645                 650                 655
Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu
            660                 665                 670
Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu
        675                 680                 685
Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val
    690                 695                 700
Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile
705                 710                 715                 720
Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg
                725                 730                 735
Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745                 750

<210> 1002
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1002
Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro
 1               5                  10                  15
Lys Pro Lys Lys Lys Gln Arg Trp Thr Arg Leu Glu Ile Ser Leu Ser
            20                  25                  30
Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Arg Met Ile Ala Leu
        35                  40                  45
Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys
    50                  55                  60
Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys
65                  70                  75                  80
Arg Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val
                85                  90                  95
Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp
            100                 105                 110
Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu
        115                 120                 125
Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile
    130                 135                 140
Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu
145                 150                 155                 160
Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln
                165                 170                 175
Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn
            180                 185                 190
Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp
        195                 200                 205
Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu
    210                 215                 220
Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu
225                 230                 235                 240
Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile
                245                 250                 255
Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu
            260                 265                 270
Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala
        275                 280                 285
Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Arg
    290                 295                 300
Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro
305                 310                 315                 320
Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile
                325                 330                 335
Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu
            340                 345                 350
Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln
        355                 360                 365
Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser
    370                 375                 380
Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly
385                 390                 395                 400
Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn
                405                 410                 415
Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe
            420                 425                 430
Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg
        435                 440                 445
Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu
    450                 455                 460
Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile
465                 470                 475                 480
Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu
                485                 490                 495
Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile
            500                 505                 510
Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu
        515                 520                 525
Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala
    530                 535                 540
Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu
545                 550                 555                 560
Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly
                565                 570                 575
Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp
            580                 585                 590
Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr
        595                 600                 605
Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr
    610                 615                 620
Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn
625                 630                 635                 640
Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly
                645                 650                 655
Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu
            660                 665                 670
Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu
        675                 680                 685
Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val
    690                 695                 700
Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile
705                 710                 715                 720
Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg
                725                 730                 735
Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745                 750

<210> 1003
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1003
Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro
 1               5                  10                  15
Lys Pro Lys Lys Lys Gln Arg Trp Thr Arg Leu Glu Ile Ser Leu Ser
            20                  25                  30
Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Arg Met Ile Ala Leu
        35                  40                  45
Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys
    50                  55                  60
Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys
65                  70                  75                  80
Arg Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val
                85                  90                  95
Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp
            100                 105                 110
Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu
        115                 120                 125
Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile
    130                 135                 140
Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu
145                 150                 155                 160
Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln
                165                 170                 175
Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn
            180                 185                 190
Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp
        195                 200                 205
Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu
    210                 215                 220
Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu
225                 230                 235                 240
Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile
                245                 250                 255
Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu
            260                 265                 270
Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala
        275                 280                 285
Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Arg
    290                 295                 300
Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro
305                 310                 315                 320
Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile
                325                 330                 335
Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu
            340                 345                 350
Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln
        355                 360                 365
Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser
    370                 375                 380
Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly
385                 390                 395                 400
Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn
                405                 410                 415
Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe
            420                 425                 430
Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg
        435                 440                 445
Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu
    450                 455                 460
Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile
465                 470                 475                 480
Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu
                485                 490                 495
Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile
            500                 505                 510
Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu
        515                 520                 525
Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala
    530                 535                 540
Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu
545                 550                 555                 560
Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly
                565                 570                 575
Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp
            580                 585                 590
Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr
        595                 600                 605
Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr
    610                 615                 620
Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn
625                 630                 635                 640
Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly
                645                 650                 655
Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu
            660                 665                 670
Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu
        675                 680                 685
Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val
    690                 695                 700
Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile
705                 710                 715                 720
Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg
                725                 730                 735
Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745                 750

<210> 1004
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1004
Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro
 1               5                  10                  15
Lys Pro Lys Lys Lys Gln Arg Trp Thr Arg Leu Glu Ile Ser Leu Ser
            20                  25                  30
Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Arg Met Ile Ala Leu
        35                  40                  45
Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys
    50                  55                  60
Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys
65                  70                  75                  80
Arg Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val
                85                  90                  95
Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp
            100                 105                 110
Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu
        115                 120                 125
Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile
    130                 135                 140
Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu
145                 150                 155                 160
Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln
                165                 170                 175
Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn
            180                 185                 190
Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp
        195                 200                 205
Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu
    210                 215                 220
Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu
225                 230                 235                 240
Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile
                245                 250                 255
Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu
            260                 265                 270
Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala
        275                 280                 285
Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Arg
    290                 295                 300
Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro
305                 310                 315                 320
Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile
                325                 330                 335
Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu
            340                 345                 350
Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln
        355                 360                 365
Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser
    370                 375                 380
Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly
385                 390                 395                 400
Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn
                405                 410                 415
Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe
            420                 425                 430
Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg
        435                 440                 445
Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu
    450                 455                 460
Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile
465                 470                 475                 480
Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu
                485                 490                 495
Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile
            500                 505                 510
Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu
        515                 520                 525
Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala
    530                 535                 540
Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu
545                 550                 555                 560
Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly
                565                 570                 575
Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp
            580                 585                 590
Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr
        595                 600                 605
Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr
    610                 615                 620
Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn
625                 630                 635                 640
Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly
                645                 650                 655
Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu
            660                 665                 670
Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu
        675                 680                 685
Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val
    690                 695                 700
Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile
705                 710                 715                 720
Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg
                725                 730                 735
Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745                 750

<210> 1005
<211> 749
<212> PRT
<213> Homo sapiens

<400> 1005
Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro Lys
 1               5                  10                  15
Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser Val
            20                  25                  30
Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu Tyr
        35                  40                  45
Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser
    50                  55                  60
Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr
65                  70                  75                  80
Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile
                85                  90                  95
Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu
            100                 105                 110
Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp
        115                 120                 125
Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn
    130                 135                 140
Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu
145                 150                 155                 160
Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys
                165                 170                 175
Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser
            180                 185                 190
Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp
        195                 200                 205
Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly
    210                 215                 220
Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala
225                 230                 235                 240
Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg
                245                 250                 255
Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met
            260                 265                 270
Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys
        275                 280                 285
Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu
    290                 295                 300
Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe
305                 310                 315                 320
Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser
                325                 330                 335
Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr
            340                 345                 350
Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn
        355                 360                 365
Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg
    370                 375                 380
Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr
385                 390                 395                 400
Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly
                405                 410                 415
Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala
            420                 425                 430
Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu
        435                 440                 445
Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr
    450                 455                 460
Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly
465                 470                 475                 480
Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr
                485                 490                 495
Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln
            500                 505                 510
Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys
        515                 520                 525
Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe
    530                 535                 540
Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln
545                 550                 555                 560
Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly
                565                 570                 575
Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn
            580                 585                 590
Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln
        595                 600                 605
Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln
    610                 615                 620
Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly
625                 630                 635                 640
Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln
                645                 650                 655
Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys
            660                 665                 670
Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn
        675                 680                 685
Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn
    690                 695                 700
Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly
705                 710                 715                 720
Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys
                725                 730                 735
Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745

<210> 1006
<211> 860
<212> PRT
<213> Homo sapiens

<400> 1006
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860

<210> 1007
<211> 280
<212> PRT
<213> Homo sapiens

<400> 1007
Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser
 1               5                  10                  15
Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp
            20                  25                  30
Thr Lys Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys
        35                  40                  45
Pro Arg Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr
    50                  55                  60
Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val
65                  70                  75                  80
Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile
                85                  90                  95
Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu
            100                 105                 110
His Ser Ile Ser Ser Ile Asp Tyr Asn Gly Gly Asn Arg Lys Thr Ile
        115                 120                 125
Leu Glu Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe
    130                 135                 140
Glu Asp Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser
145                 150                 155                 160
Ala Asn Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu
                165                 170                 175
Leu Ser Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg
            180                 185                 190
Gly Val Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln
        195                 200                 205
Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe
    210                 215                 220
Thr Cys Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser
225                 230                 235                 240
Cys Leu Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr
                245                 250                 255
Val Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr
            260                 265                 270
Thr Arg Pro Val Pro Asp Thr Ser
        275                 280

<210> 1008
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1008
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1009
<211> 563
<212> PRT
<213> Homo sapiens

<400> 1009
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Asn Arg Val Leu Phe Met Lys Pro Lys Gly Arg
    130                 135                 140
Gly Leu Lys His Met Phe Gly Asp Leu Val Cys Ser Trp Lys Leu Ala
145                 150                 155                 160
Ala Ile Glu Thr Gln Ser Ser Ser Ser Glu Glu Ile Val Pro Ser Pro
                165                 170                 175
Pro Ser Pro Pro Pro Leu Pro Arg Ile Tyr Lys Pro Cys Phe Val Cys
            180                 185                 190
Gln Asp Lys Ser Ser Gly Tyr His Tyr Gly Val Ser Ala Cys Glu Gly
        195                 200                 205
Cys Lys Gly Phe Phe Arg Arg Ser Ile Gln Lys Asn Met Val Tyr Thr
    210                 215                 220
Cys His Arg Asp Lys Asn Cys Ile Ile Asn Lys Val Thr Arg Asn Arg
225                 230                 235                 240
Cys Gln Tyr Cys Arg Leu Gln Lys Cys Phe Glu Val Gly Met Ser Lys
                245                 250                 255
Glu Ser Val Arg Asn Asp Arg Asn Lys Lys Lys Lys Glu Val Pro Lys
            260                 265                 270
Pro Glu Cys Ser Glu Ser Tyr Thr Leu Thr Pro Glu Val Gly Glu Leu
        275                 280                 285
Ile Glu Lys Val Arg Lys Ala His Gln Glu Thr Phe Pro Ala Leu Cys
    290                 295                 300
Gln Leu Gly Lys Tyr Thr Thr Asn Asn Ser Ser Glu Gln Arg Val Ser
305                 310                 315                 320
Leu Asp Ile Asp Leu Trp Asp Lys Phe Ser Glu Leu Ser Thr Lys Cys
                325                 330                 335
Ile Ile Lys Thr Val Glu Phe Ala Lys Gln Leu Pro Gly Phe Thr Thr
            340                 345                 350
Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys Ala Ala Cys Leu Asp
        355                 360                 365
Ile Leu Ile Leu Arg Ile Cys Thr Arg Tyr Thr Pro Glu Gln Asp Thr
    370                 375                 380
Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg Thr Gln Met His Asn
385                 390                 395                 400
Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe Ala Phe Ala Asn Gln
                405                 410                 415
Leu Leu Pro Leu Glu Met Asp Asp Ala Glu Thr Gly Leu Leu Ser Ala
            420                 425                 430
Ile Cys Leu Ile Cys Gly Asp Arg Gln Asp Leu Glu Gln Pro Asp Arg
        435                 440                 445
Val Asp Met Leu Gln Glu Pro Leu Leu Glu Ala Leu Lys Val Tyr Val
    450                 455                 460
Arg Lys Arg Arg Pro Ser Arg Pro His Met Phe Pro Lys Met Leu Met
465                 470                 475                 480
Lys Ile Thr Asp Leu Arg Ser Ile Ser Ala Lys Gly Ala Glu Arg Val
                485                 490                 495
Ile Thr Leu Lys Met Glu Ile Pro Gly Ser Met Pro Pro Leu Ile Gln
            500                 505                 510
Glu Met Leu Glu Asn Ser Glu Gly Leu Asp Thr Leu Ser Gly Gln Pro
        515                 520                 525
Gly Gly Gly Gly Arg Asp Gly Gly Gly Leu Ala Pro Pro Pro Gly Ser
    530                 535                 540
Cys Ser Pro Ser Leu Ser Pro Ser Ser Asn Arg Ser Ser Pro Ala Thr
545                 550                 555                 560
His Ser Pro


<210> 1010
<211> 520
<212> PRT
<213> Homo sapiens

<400> 1010
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Ile Glu Thr Gln Ser Ser Ser Ser Glu Glu
        115                 120                 125
Ile Val Pro Ser Pro Pro Ser Pro Pro Pro Leu Pro Arg Ile Tyr Lys
    130                 135                 140
Pro Cys Phe Val Cys Gln Asp Lys Ser Ser Gly Tyr His Tyr Gly Val
145                 150                 155                 160
Ser Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile Gln Lys
                165                 170                 175
Asn Met Val Tyr Thr Cys His Arg Asp Lys Asn Cys Ile Ile Asn Lys
            180                 185                 190
Val Thr Arg Asn Arg Cys Gln Tyr Cys Arg Leu Gln Lys Cys Phe Glu
        195                 200                 205
Val Gly Met Ser Lys Glu Ser Val Arg Asn Asp Arg Asn Lys Lys Lys
    210                 215                 220
Lys Glu Val Pro Lys Pro Glu Cys Ser Glu Ser Tyr Thr Leu Thr Pro
225                 230                 235                 240
Glu Val Gly Glu Leu Ile Glu Lys Val Arg Lys Ala His Gln Glu Thr
                245                 250                 255
Phe Pro Ala Leu Cys Gln Leu Gly Lys Tyr Thr Thr Asn Asn Ser Ser
            260                 265                 270
Glu Gln Arg Val Ser Leu Asp Ile Asp Leu Trp Asp Lys Phe Ser Glu
        275                 280                 285
Leu Ser Thr Lys Cys Ile Ile Lys Thr Val Glu Phe Ala Lys Gln Leu
    290                 295                 300
Pro Gly Phe Thr Thr Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys
305                 310                 315                 320
Ala Ala Cys Leu Asp Ile Leu Ile Leu Arg Ile Cys Thr Arg Tyr Thr
                325                 330                 335
Pro Glu Gln Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg
            340                 345                 350
Thr Gln Met His Asn Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe
        355                 360                 365
Ala Phe Ala Asn Gln Leu Leu Pro Leu Glu Met Asp Asp Ala Glu Thr
    370                 375                 380
Gly Leu Leu Ser Ala Ile Cys Leu Ile Cys Gly Asp Arg Gln Asp Leu
385                 390                 395                 400
Glu Gln Pro Asp Arg Val Asp Met Leu Gln Glu Pro Leu Leu Glu Ala
                405                 410                 415
Leu Lys Val Tyr Val Arg Lys Arg Arg Pro Ser Arg Pro His Met Phe
            420                 425                 430
Pro Lys Met Leu Met Lys Ile Thr Asp Leu Arg Ser Ile Ser Ala Lys
        435                 440                 445
Gly Ala Glu Arg Val Ile Thr Leu Lys Met Glu Ile Pro Gly Ser Met
    450                 455                 460
Pro Pro Leu Ile Gln Glu Met Leu Glu Asn Ser Glu Gly Leu Asp Thr
465                 470                 475                 480
Leu Ser Gly Gln Pro Gly Gly Gly Gly Arg Asp Gly Gly Gly Leu Ala
                485                 490                 495
Pro Pro Pro Gly Ser Cys Ser Pro Ser Leu Ser Pro Ser Ser Asn Arg
            500                 505                 510
Ser Ser Pro Ala Thr His Ser Pro
        515                 520

<210> 1011
<211> 259
<212> PRT
<213> Homo sapiens

<400> 1011
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Ala His


<210> 1012
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1012
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1013
<211> 680
<212> PRT
<213> Homo sapiens

<400> 1013
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala
        115                 120                 125
Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg
    130                 135                 140
Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly
145                 150                 155                 160
Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile
                165                 170                 175
Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu
            180                 185                 190
Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala
        195                 200                 205
Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe
    210                 215                 220
Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val
225                 230                 235                 240
Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu
                245                 250                 255
Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg
            260                 265                 270
Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His
        275                 280                 285
Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His
    290                 295                 300
Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro
305                 310                 315                 320
Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp
                325                 330                 335
Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro
            340                 345                 350
Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser
        355                 360                 365
Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser
    370                 375                 380
Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu
385                 390                 395                 400
Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly
                405                 410                 415
Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp
            420                 425                 430
Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln
        435                 440                 445
Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu
    450                 455                 460
Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly
465                 470                 475                 480
Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg
                485                 490                 495
Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala
            500                 505                 510
Ala Lys Lys Pro Thr Ala Ala Glu Val Ser Val Arg Val Pro Arg Gly
        515                 520                 525
Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn
    530                 535                 540
Pro Pro Ser Glu Leu His Arg Val His Gly Ser Arg Asn Lys Pro Thr
545                 550                 555                 560
Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr
                565                 570                 575
Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Glu Arg Gly Asn
            580                 585                 590
Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly
        595                 600                 605
Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala
    610                 615                 620
Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly
625                 630                 635                 640
Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala
                645                 650                 655
Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys
            660                 665                 670
Asn Ser Met Asn Gln Pro Gly Pro
        675                 680

<210> 1014
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1014
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Phe Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1015
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1015
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1016
<211> 265
<212> PRT
<213> Homo sapiens

<400> 1016
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Gly Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr
        195                 200                 205
Pro Lys Gly Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala
    210                 215                 220
Ser Ile Glu Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile
225                 230                 235                 240
Asn Tyr Val Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln
                245                 250                 255
Asp Leu Trp Gln Trp Arg Lys Ser Leu
            260                 265

<210> 1017
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1017
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1018
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1018
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Gly Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Cys Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1019
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1019
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1020
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1020
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1021
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1021
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1022
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1022
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1023
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1023
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1024
<211> 680
<212> PRT
<213> Homo sapiens

<400> 1024
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala
        115                 120                 125
Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg
    130                 135                 140
Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly
145                 150                 155                 160
Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile
                165                 170                 175
Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu
            180                 185                 190
Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala
        195                 200                 205
Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe
    210                 215                 220
Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val
225                 230                 235                 240
Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu
                245                 250                 255
Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg
            260                 265                 270
Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His
        275                 280                 285
Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His
    290                 295                 300
Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro
305                 310                 315                 320
Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp
                325                 330                 335
Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro
            340                 345                 350
Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser
        355                 360                 365
Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser
    370                 375                 380
Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu
385                 390                 395                 400
Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly
                405                 410                 415
Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp
            420                 425                 430
Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln
        435                 440                 445
Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu
    450                 455                 460
Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly
465                 470                 475                 480
Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg
                485                 490                 495
Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala
            500                 505                 510
Ala Lys Lys Pro Thr Ala Ala Glu Val Ser Val Arg Val Pro Arg Gly
        515                 520                 525
Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn
    530                 535                 540
Pro Pro Ser Glu Leu His Lys Val His Gly Ser Arg Asn Lys Pro Thr
545                 550                 555                 560
Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr
                565                 570                 575
Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Asp Arg Gly Asn
            580                 585                 590
Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly
        595                 600                 605
Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala
    610                 615                 620
Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly
625                 630                 635                 640
Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala
                645                 650                 655
Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys
            660                 665                 670
Asn Ser Met Asn Gln Pro Gly Pro
        675                 680

<210> 1025
<211> 280
<212> PRT
<213> Homo sapiens

<400> 1025
Gln Asn Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His
 1               5                  10                  15
Phe Lys Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr
            20                  25                  30
Val Ser Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala
        35                  40                  45
Glu Ala Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr
    50                  55                  60
Leu Lys Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile
65                  70                  75                  80
Thr Pro Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His
                85                  90                  95
Ile Ser Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu
            100                 105                 110
Asp Glu Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg
        115                 120                 125
Ser Ala Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu
    130                 135                 140
Ala Ala Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu
145                 150                 155                 160
Asp Asp Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala
                165                 170                 175
Pro Val Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys
            180                 185                 190
Ser Asn Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser
        195                 200                 205
Lys Gly Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro
    210                 215                 220
Lys Gly Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser
225                 230                 235                 240
Ile Glu Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn
                245                 250                 255
Tyr Val Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp
            260                 265                 270
Leu Trp Gln Trp Arg Lys Ser Leu
        275                 280

<210> 1026
<211> 317
<212> PRT
<213> Homo sapiens

<400> 1026
Cys Ser Leu Glu Gln Arg Ser Phe Ile Ser Val Arg Leu Leu Ser Tyr
 1               5                  10                  15
Leu Ser Ala Cys Arg His Pro Met Glu Asp Ser Met Asp Met Asp Met
            20                  25                  30
Ser Pro Leu Arg Pro Gln Asn Tyr Leu Phe Gly Cys Glu Leu Lys Ala
        35                  40                  45
Asp Lys Asp Tyr His Phe Lys Val Asp Asn Asp Glu Asn Glu His Gln
    50                  55                  60
Leu Ser Leu Arg Thr Val Ser Leu Gly Ala Gly Ala Lys Asp Glu Leu
65                  70                  75                  80
His Ile Val Glu Ala Glu Ala Met Asn Tyr Glu Gly Ser Pro Ile Lys
                85                  90                  95
Val Thr Leu Ala Thr Leu Lys Met Ser Val Gln Pro Thr Val Ser Leu
            100                 105                 110
Gly Gly Phe Glu Ile Thr Pro Pro Val Val Leu Arg Leu Lys Cys Gly
        115                 120                 125
Ser Gly Pro Val His Ile Ser Gly Gln His Leu Val Ala Val Glu Glu
    130                 135                 140
Asp Ala Glu Ser Glu Asp Glu Glu Glu Glu Asp Val Lys Leu Leu Ser
145                 150                 155                 160
Ile Ser Gly Lys Arg Ser Ala Pro Gly Gly Gly Ser Lys Val Pro Gln
                165                 170                 175
Lys Lys Val Lys Leu Ala Ala Asp Glu Asp Asp Asp Asp Asp Asp Glu
            180                 185                 190
Glu Asp Asp Asp Glu Asp Asp Asp Asp Asp Asp Phe Asp Asp Glu Glu
        195                 200                 205
Ala Glu Glu Lys Ala Pro Val Lys Lys Ser Ile Arg Asp Thr Pro Ala
    210                 215                 220
Lys Asn Ala Gln Lys Ser Asn Gln Asn Gly Lys Asp Ser Lys Pro Ser
225                 230                 235                 240
Ser Thr Pro Arg Ser Lys Gly Gln Glu Ser Phe Lys Lys Gln Glu Lys
                245                 250                 255
Thr Pro Lys Thr Pro Lys Gly Pro Ser Ser Val Glu Asp Ile Lys Ala
            260                 265                 270
Lys Met Gln Ala Ser Ile Glu Lys Gly Gly Ser Leu Pro Lys Val Glu
        275                 280                 285
Ala Lys Phe Ile Asn Tyr Val Lys Asn Cys Phe Arg Met Thr Asp Gln
    290                 295                 300
Glu Ala Ile Gln Asp Leu Trp Gln Trp Arg Lys Ser Leu
305                 310                 315

<210> 1027
<211> 138
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(138)
<223> Xaa = Any Amino Acid

<400> 1027
Gly Cys Ser Leu Glu Gln Arg Ser Phe Ile Ser Val Arg Leu Leu Ser
 1               5                  10                  15
Tyr Leu Ser Ala Cys Arg His Pro Met Glu Asp Ser Met Asp Met Asp
            20                  25                  30
Met Ser Pro Leu Arg Pro Gln Asn Tyr Leu Phe Gly Cys Glu Leu Lys
        35                  40                  45
Ala Asp Lys Asp Tyr His Phe Lys Val Asp Asn Xaa Glu Asn Glu His
    50                  55                  60
Gln Leu Ser Leu Arg Thr Val Xaa Xaa Gly Ala Gly Ala Lys Asp Glu
65                  70                  75                  80
Leu His Ile Val Glu Ala Glu Ala Met Asn Tyr Glu Gly Ser Pro Ile
                85                  90                  95
Lys Val Thr Leu Ala Thr Leu Lys Met Ser Val Gln Pro Thr Val Phe
            100                 105                 110
Pro Leu Gly Ala Leu Asn Asn Thr Thr Xaa Xaa Leu Lys Val Glu Xaa
        115                 120                 125
Trp Phe Arg Ala Met Pro Ile Xaa Gly Gln
    130                 135

<210> 1028
<211> 680
<212> PRT
<213> Homo sapiens

<400> 1028
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala
        115                 120                 125
Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg
    130                 135                 140
Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly
145                 150                 155                 160
Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile
                165                 170                 175
Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu
            180                 185                 190
Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala
        195                 200                 205
Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe
    210                 215                 220
Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val
225                 230                 235                 240
Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu
                245                 250                 255
Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg
            260                 265                 270
Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His
        275                 280                 285
Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His
    290                 295                 300
Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro
305                 310                 315                 320
Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp
                325                 330                 335
Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro
            340                 345                 350
Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser
        355                 360                 365
Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser
    370                 375                 380
Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu
385                 390                 395                 400
Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly
                405                 410                 415
Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp
            420                 425                 430
Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln
        435                 440                 445
Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu
    450                 455                 460
Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly
465                 470                 475                 480
Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg
                485                 490                 495
Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala
            500                 505                 510
Ala Lys Lys Pro Thr Ala Ala Glu Val Ser Val Arg Val Pro Arg Gly
        515                 520                 525
Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn
    530                 535                 540
Pro Pro Ser Glu Leu His Lys Val His Gly Ser Arg Asn Lys Pro Thr
545                 550                 555                 560
Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr
                565                 570                 575
Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Asp Arg Gly Asn
            580                 585                 590
Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly
        595                 600                 605
Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala
    610                 615                 620
Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly
625                 630                 635                 640
Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala
                645                 650                 655
Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys
            660                 665                 670
Asn Ser Met Asn Gln Pro Gly Pro
        675                 680

<210> 1029
<211> 136
<212> PRT
<213> Homo sapiens

<400> 1029
Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn Asn Leu Phe
 1               5                  10                  15
Arg Cys Glu Leu Lys Ala Asp Asn His Phe Gln Val Asp Asn Asp Glu
            20                  25                  30
Asn Glu His Gln Leu Ser Ser Arg Thr Val Ser Ser Gly Ala Gly Ala
        35                  40                  45
Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala Met Asn Tyr Glu Gly
    50                  55                  60
Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys Met Ser Val Gln Pro
65                  70                  75                  80
Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro Pro Val Val Leu Arg
                85                  90                  95
Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser Gly Gln His Leu Val
            100                 105                 110
Thr Val Glu Glu Asp Ser Glu Ala Glu Asp Glu Glu Gln Glu Asp Val
        115                 120                 125
Lys Leu Leu Ser Ile Tyr Gly Lys
    130                 135

<210> 1030
<211> 136
<212> PRT
<213> Homo sapiens

<400> 1030
Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn Asn Leu Phe
 1               5                  10                  15
Arg Cys Glu Leu Lys Ala Asp Asn His Phe Gln Val Asp Asn Asp Glu
            20                  25                  30
Asn Glu His Gln Leu Ser Ser Arg Thr Val Ser Ser Gly Ala Gly Ala
        35                  40                  45
Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala Met Asn Tyr Glu Gly
    50                  55                  60
Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys Met Ser Val Gln Pro
65                  70                  75                  80
Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro Pro Val Val Leu Arg
                85                  90                  95
Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser Gly Gln His Leu Val
            100                 105                 110
Thr Val Glu Glu Asp Ser Glu Ala Glu Asp Glu Glu Gln Glu Asp Val
        115                 120                 125
Lys Leu Leu Ser Ile Tyr Gly Lys
    130                 135

<210> 1031
<211> 136
<212> PRT
<213> Homo sapiens

<400> 1031
Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn Asn Leu Phe
 1               5                  10                  15
Arg Cys Glu Leu Lys Ala Asp Asn His Phe Gln Val Asp Asn Asp Glu
            20                  25                  30
Asn Glu His Gln Leu Ser Ser Arg Thr Val Ser Ser Gly Ala Gly Ala
        35                  40                  45
Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala Met Asn Tyr Glu Gly
    50                  55                  60
Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys Met Ser Val Gln Pro
65                  70                  75                  80
Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro Pro Val Val Leu Arg
                85                  90                  95
Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser Gly Gln His Leu Val
            100                 105                 110
Thr Val Glu Glu Asp Ser Glu Ala Glu Asp Glu Glu Gln Glu Asp Val
        115                 120                 125
Lys Leu Leu Ser Ile Tyr Gly Lys
    130                 135

<210> 1032
<211> 136
<212> PRT
<213> Homo sapiens

<400> 1032
Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn Asn Leu Phe
 1               5                  10                  15
Arg Cys Glu Leu Lys Ala Asp Asn His Phe Gln Val Asp Asn Asp Glu
            20                  25                  30
Asn Glu His Gln Leu Ser Ser Arg Thr Val Ser Ser Gly Ala Gly Ala
        35                  40                  45
Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala Met Asn Tyr Glu Gly
    50                  55                  60
Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys Met Ser Val Gln Pro
65                  70                  75                  80
Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro Pro Val Val Leu Arg
                85                  90                  95
Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser Gly Gln His Leu Val
            100                 105                 110
Thr Val Glu Glu Asp Ser Glu Ala Glu Asp Glu Glu Gln Glu Asp Val
        115                 120                 125
Lys Leu Leu Ser Ile Tyr Gly Lys
    130                 135

<210> 1033
<211> 136
<212> PRT
<213> Homo sapiens

<400> 1033
Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn Asn Leu Phe
 1               5                  10                  15
Arg Cys Glu Leu Lys Ala Asp Asn His Phe Gln Val Asp Asn Asp Glu
            20                  25                  30
Asn Glu His Gln Leu Ser Ser Arg Thr Val Ser Ser Gly Ala Gly Ala
        35                  40                  45
Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala Met Asn Tyr Glu Gly
    50                  55                  60
Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys Met Ser Val Gln Pro
65                  70                  75                  80
Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro Pro Val Val Leu Arg
                85                  90                  95
Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser Gly Gln His Leu Val
            100                 105                 110
Thr Val Glu Glu Asp Ser Glu Ala Glu Asp Glu Glu Gln Glu Asp Val
        115                 120                 125
Lys Leu Leu Ser Ile Tyr Gly Lys
    130                 135

<210> 1034
<211> 525
<212> PRT
<213> Homo sapiens

<400> 1034
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala
        115                 120                 125
Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg
    130                 135                 140
Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly
145                 150                 155                 160
Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile
                165                 170                 175
Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu
            180                 185                 190
Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala
        195                 200                 205
Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe
    210                 215                 220
Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val
225                 230                 235                 240
Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu
                245                 250                 255
Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg
            260                 265                 270
Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His
        275                 280                 285
Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His
    290                 295                 300
Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro
305                 310                 315                 320
Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp
                325                 330                 335
Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro
            340                 345                 350
Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser
        355                 360                 365
Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser
    370                 375                 380
Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu
385                 390                 395                 400
Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly
                405                 410                 415
Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp
            420                 425                 430
Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln
        435                 440                 445
Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu
    450                 455                 460
Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly
465                 470                 475                 480
Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Gln
                485                 490                 495
Pro Ser Cys Pro Thr Thr Ser Ala Tyr His Leu Leu Trp Gln Gly Cys
            500                 505                 510
Lys Glu Thr His Ser Cys Arg Gly Leu Cys Ser Ser Pro
        515                 520                 525

<210> 1035
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1035
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1036
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1036
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1037
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1037
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Gly Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Cys Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1038
<211> 265
<212> PRT
<213> Homo sapiens

<400> 1038
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Gly Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr
        195                 200                 205
Pro Lys Gly Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala
    210                 215                 220
Ser Ile Glu Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile
225                 230                 235                 240
Asn Tyr Val Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln
                245                 250                 255
Asp Leu Trp Gln Trp Arg Lys Ser Leu
            260                 265

<210> 1039
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1039
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Phe Trp
        275                 280                 285
Gln Trp Arg Lys Ser Leu
    290

<210> 1040
<211> 259
<212> PRT
<213> Homo sapiens

<400> 1040
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255
Lys Ala His


<210> 1041
<211> 272
<212> PRT
<213> Homo sapiens

<400> 1041
Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn Phe
 1               5                  10                  15
Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn
            20                  25                  30
Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu
        35                  40                  45
Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu Leu
    50                  55                  60
Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val Ile
65                  70                  75                  80
Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr Asp
                85                  90                  95
Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp
            100                 105                 110
Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val Val
        115                 120                 125
Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln Lys
    130                 135                 140
Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val
145                 150                 155                 160
Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys Asn
                165                 170                 175
Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser Leu
            180                 185                 190
Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val Ser
        195                 200                 205
His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val
    210                 215                 220
Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu
225                 230                 235                 240
Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly
                245                 250                 255
Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala Lys
            260                 265                 270

<210> 1042
<211> 336
<212> PRT
<213> Homo sapiens

<400> 1042
Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu Gly Val
 1               5                  10                  15
Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val Pro Leu
            20                  25                  30
Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile Leu Pro
        35                  40                  45
Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly Asn Lys
    50                  55                  60
Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn Phe
65                  70                  75                  80
Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn
                85                  90                  95
Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu
            100                 105                 110
Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu Leu
        115                 120                 125
Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val Ile
    130                 135                 140
Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr Asp
145                 150                 155                 160
Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp
                165                 170                 175
Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val Val
            180                 185                 190
Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln Lys
        195                 200                 205
Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val
    210                 215                 220
Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys Asn
225                 230                 235                 240
Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser Leu
                245                 250                 255
Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val Ser
            260                 265                 270
His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val
        275                 280                 285
Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu
    290                 295                 300
Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly
305                 310                 315                 320
Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala Lys
                325                 330                 335

<210> 1043
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1043
Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn Phe Arg Glu Ala
 1               5                  10                  15
Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn Val Ile Lys
            20                  25                  30
Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu Gly Gly Phe
        35                  40                  45
Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu Leu Leu Lys Thr
    50                  55                  60
Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val Ile Gly Met Asp
65                  70                  75                  80
Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr Asp Leu Asp Phe
                85                  90                  95
Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp Gln Leu Ala
            100                 105                 110
Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val Val Ser Ile Glu
        115                 120                 125
Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln Lys Phe Thr Ala
    130                 135                 140
Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val Thr Asn Pro
145                 150                 155                 160
Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys Asn Cys Leu Leu
                165                 170                 175
Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser Leu Gln Ala Cys
            180                 185                 190
Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val Ser His Arg Ser
        195                 200                 205
Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val Gly Leu Cys
    210                 215                 220
Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala
225                 230                 235                 240
Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly Ser Lys Ala
                245                 250                 255
Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala Lys
            260                 265

<210> 1044
<211> 272
<212> PRT
<213> Homo sapiens

<400> 1044
Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn Phe
 1               5                  10                  15
Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn
            20                  25                  30
Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu
        35                  40                  45
Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu Leu
    50                  55                  60
Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val Ile
65                  70                  75                  80
Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr Asp
                85                  90                  95
Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp
            100                 105                 110
Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val Val
        115                 120                 125
Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln Lys
    130                 135                 140
Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val
145                 150                 155                 160
Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys Asn
                165                 170                 175
Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser Leu
            180                 185                 190
Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val Ser
        195                 200                 205
His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val
    210                 215                 220
Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu
225                 230                 235                 240
Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly
                245                 250                 255
Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala Lys
            260                 265                 270

<210> 1045
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1045
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 1046
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1046
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 1047
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1047
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 1048
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1048
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 1049
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1049
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Gly Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 1050
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1050
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 1051
<211> 467
<212> PRT
<213> Homo sapiens

<400> 1051
Ser Arg Ser Lys Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly
 1               5                  10                  15
Val Ala Ala Gln Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile
            20                  25                  30
Gln Pro Ser Arg Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala
        35                  40                  45
Gln Gln Phe Gly Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His
    50                  55                  60
Trp Lys Pro Pro Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile
65                  70                  75                  80
Val Lys Asn Ile Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His
                85                  90                  95
Gly Val Leu Arg Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys
            100                 105                 110
Cys Asp Pro His Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile
        115                 120                 125
Glu Tyr Lys Thr Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp
    130                 135                 140
Tyr Val Ser Met Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu
145                 150                 155                 160
Lys Leu Leu Asn Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val
                165                 170                 175
Leu Phe Gly Glu Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr
            180                 185                 190
Thr His Ala Leu Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe
        195                 200                 205
Glu Glu Arg Glu Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala
    210                 215                 220
Arg Met His Ala Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu
225                 230                 235                 240
Pro Leu Gly Leu Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser
                245                 250                 255
Leu Arg Leu Asp Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp
            260                 265                 270
Arg Asn Arg Thr Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu
        275                 280                 285
Asn Tyr Gly Phe Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp
    290                 295                 300
Asp Leu Arg Lys Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe
305                 310                 315                 320
Asp Val Pro Val Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys
                325                 330                 335
Arg Val Glu Glu Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu
            340                 345                 350
Asn Lys Met Pro Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser
        355                 360                 365
Pro Pro Lys Arg Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His
    370                 375                 380
His Phe Lys Leu Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr
385                 390                 395                 400
Tyr Thr Ala Ile Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val
                405                 410                 415
Ser Asp Gly Ser Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly
            420                 425                 430
Phe Ala His Leu Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu
        435                 440                 445
Ala Asp Val Val Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu
    450                 455                 460
Val Asp Arg
465

<210> 1052
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1052
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 1053
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1053
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Gly Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 1054
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1054
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 1055
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 1055
Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala
 1               5                  10                  15
Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly
            20                  25                  30
Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala
        35                  40                  45
Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys
    50                  55                  60
Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr
65                  70                  75                  80
Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro
                85                  90                  95
Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr
            100                 105                 110
Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr
        115                 120                 125
Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg
    130                 135                 140
Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly
145                 150                 155                 160
Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr
                165                 170                 175
Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser
            180                 185                 190
Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys
        195                 200                 205
Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys
    210                 215                 220
Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp
225                 230                 235                 240
Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly
                245                 250                 255
Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu
            260                 265                 270
Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro
        275                 280                 285
Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp
    290                 295                 300
Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg
305                 310                 315                 320
Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile
                325                 330                 335
Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser
            340                 345                 350
His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser
        355                 360                 365
Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val
    370                 375                 380
Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu
385                 390                 395                 400
Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile
                405                 410                 415
Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp
            420                 425                 430
Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg
        435                 440                 445
Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys
    450                 455                 460
Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg
465                 470                 475                 480
Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp
                485                 490                 495
Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile
            500                 505                 510
Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser
        515                 520                 525
Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu
    530                 535                 540
Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile
545                 550                 555                 560
Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe
                565                 570                 575
Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys
            580                 585                 590
Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp
        595                 600                 605
Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro
    610                 615                 620
Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys
625                 630                 635                 640
Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn
                645                 650                 655
Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val
            660                 665                 670
Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr
        675                 680                 685
Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp
    690                 695                 700
Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys
705                 710                 715                 720
Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln
                725                 730                 735
Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala
            740                 745                 750
Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly
        755                 760                 765
Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn
    770                 775                 780
Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr
785                 790                 795                 800
Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser
                805                 810                 815
Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr
            820                 825                 830
Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly
        835                 840                 845
Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln
    850                 855                 860
Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr
865                 870                 875                 880
Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile
                885                 890                 895
Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile
            900                 905                 910
Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys
        915                 920                 925
Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr
    930                 935                 940
Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe
945                 950                 955                 960
Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys
                965                 970                 975
Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile
            980                 985                 990
Arg Asp Gly Phe Ala Glu Leu Gln Met Asp Lys Leu Asp Val Val Asp
        995                 1000                1005
Ser Phe Gly Thr Val Pro Phe Leu Asp Tyr Lys His Phe Ala Leu Arg
    1010                1015                1020
Thr Phe Phe Pro Glu Ser Gly Gly Phe Thr His Ile Phe Thr Glu Asp
1025                1030                1035                1040
Met His Asn Arg Asp Ala Asn Asp Lys Asn Glu Ser Leu Thr Ala Leu
                1045                1050                1055
Asp Ala Leu Ile Cys Asn Lys Ser Phe Leu Val Thr Val Ile His Thr
            1060                1065                1070
Leu Glu Lys Gln Lys Asn Phe Ser Val Lys Asp Arg Cys Leu Phe Ala
        1075                1080                1085
Ser Phe Leu Thr Ile Ala Leu Gln Thr Lys Leu Val Tyr Leu Thr Ser
    1090                1095                1100
Ile Leu Glu Val Leu Thr Arg Asp Leu Met Glu Gln Cys Ser Asn Met
1105                1110                1115                1120
Gln Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys Leu
                1125                1130                1135
Leu Thr Asn Trp Met Ser Val Cys Leu Ser Gly Phe Leu Arg Glu Thr
            1140                1145                1150
Val Gly Glu Pro Phe Tyr Leu Leu Val Thr Thr Leu Asn Gln Lys Ile
        1155                1160                1165
Asn Lys Gly Pro Val Asp Val Ile Thr Cys Lys Ala Leu Tyr Thr Leu
    1170                1175                1180
Asn Glu Asp Trp Leu Leu Trp Gln Val Pro Glu Phe Ser Thr Val Ala
1185                1190                1195                1200
Leu Asn Val Val Phe Glu Lys Ile Pro Glu Asn Glu Ser Ala Asp Val
                1205                1210                1215
Cys Arg Asn Ile Ser Val Asn Val Leu Asp Cys Asp Thr Ile Gly Gln
            1220                1225                1230
Ala Lys Glu Lys Ile Phe Gln Ala Phe Leu Ser Lys Asn Gly Ser Pro
        1235                1240                1245
Tyr Gly Leu Gln Leu Asn Glu Ile Gly Leu Glu Leu Gln Met Gly Thr
    1250                1255                1260
Arg Gln Lys Glu Leu Leu Asp Ile Asp Ser Ser Ser Val Ile Leu Glu
1265                1270                1275                1280
Asp Gly Ile Thr Lys Leu Asn Thr Ile Gly His Tyr Glu Ile Ser Asn
                1285                1290                1295
Gly Ser Thr Ile Lys Val Phe Lys Lys Ile Ala Asn Phe Thr Ser Asp
            1300                1305                1310
Val Glu Tyr Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu
        1315                1320                1325
Ala Phe Gln Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe
    1330                1335                1340
Lys Val Lys Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Val Ala
1345                1350                1355                1360
Ile His Ser Val Leu Glu Lys Leu Phe Arg Ser Ile Trp Ser Leu Pro
                1365                1370                1375
Asn Ser Arg Ala Pro Phe Ala Ile Lys Tyr Phe Phe Asp Phe Leu Asp
            1380                1385                1390
Ala Gln Ala Glu Asn Lys Lys Ile Thr Asp Pro Asp Val Val His Ile
        1395                1400                1405
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys
    1410                1415                1420
Asn Pro Gln Phe Val Phe Asp Ile Lys Lys Thr Pro His Ile Asp Gly
1425                1430                1435                1440
Cys Leu Ser Val Ile Ala Gln Ala Phe Met Asp Ala Phe Ser Leu Thr
                1445                1450                1455
Glu Gln Gln Leu Gly Lys Glu Ala Pro Thr Asn Lys Leu Leu Tyr Ala
            1460                1465                1470
Lys Asp Ile Pro Thr Tyr Lys Glu Glu Val Lys Ser Tyr Tyr Lys Ala
        1475                1480                1485
Ile Arg Asp Leu Pro Pro Leu Ser Ser Ser Glu Met Glu Glu Phe Leu
    1490                1495                1500
Thr Gln Glu Ser Lys Lys His Glu Asn Glu Phe Asn Glu Glu Val Ala
1505                1510                1515                1520
Leu Thr Glu Ile Tyr Lys Tyr Ile Val Lys Tyr Phe Asp Glu Ile Leu
                1525                1530                1535
Asn Lys Leu Glu Arg Glu Arg Gly Leu Glu Glu Ala Gln Lys Gln Leu
            1540                1545                1550
Leu His Val Lys Val Leu Phe Asp Glu Lys Lys Lys Cys Lys Trp Met
        1555                1560                1565

<210> 1056
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 1056
Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala
 1               5                  10                  15
Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly
            20                  25                  30
Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala
        35                  40                  45
Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys
    50                  55                  60
Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr
65                  70                  75                  80
Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro
                85                  90                  95
Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr
            100                 105                 110
Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr
        115                 120                 125
Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg
    130                 135                 140
Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly
145                 150                 155                 160
Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr
                165                 170                 175
Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser
            180                 185                 190
Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys
        195                 200                 205
Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys
    210                 215                 220
Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp
225                 230                 235                 240
Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly
                245                 250                 255
Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu
            260                 265                 270
Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro
        275                 280                 285
Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp
    290                 295                 300
Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg
305                 310                 315                 320
Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile
                325                 330                 335
Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser
            340                 345                 350
His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser
        355                 360                 365
Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val
    370                 375                 380
Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu
385                 390                 395                 400
Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile
                405                 410                 415
Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp
            420                 425                 430
Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg
        435                 440                 445
Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys
    450                 455                 460
Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg
465                 470                 475                 480
Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp
                485                 490                 495
Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile
            500                 505                 510
Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser
        515                 520                 525
Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu
    530                 535                 540
Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile
545                 550                 555                 560
Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe
                565                 570                 575
Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys
            580                 585                 590
Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp
        595                 600                 605
Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro
    610                 615                 620
Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys
625                 630                 635                 640
Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn
                645                 650                 655
Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val
            660                 665                 670
Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr
        675                 680                 685
Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp
    690                 695                 700
Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys
705                 710                 715                 720
Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln
                725                 730                 735
Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala
            740                 745                 750
Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly
        755                 760                 765
Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn
    770                 775                 780
Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr
785                 790                 795                 800
Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser
                805                 810                 815
Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr
            820                 825                 830
Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly
        835                 840                 845
Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln
    850                 855                 860
Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr
865                 870                 875                 880
Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile
                885                 890                 895
Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile
            900                 905                 910
Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys
        915                 920                 925
Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr
    930                 935                 940
Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe
945                 950                 955                 960
Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys
                965                 970                 975
Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile
            980                 985                 990
Arg Asp Gly Phe Ala Glu Leu Gln Met Asp Lys Leu Asp Val Val Asp
        995                 1000                1005
Ser Phe Gly Thr Val Pro Phe Leu Asp Tyr Lys His Phe Ala Leu Arg
    1010                1015                1020
Thr Phe Phe Pro Glu Ser Gly Gly Phe Thr His Ile Phe Thr Glu Asp
1025                1030                1035                1040
Met His Asn Arg Asp Ala Asn Asp Lys Asn Glu Ser Leu Thr Ala Leu
                1045                1050                1055
Asp Ala Leu Ile Cys Asn Lys Ser Phe Leu Val Thr Val Ile His Thr
            1060                1065                1070
Leu Glu Lys Gln Lys Asn Phe Ser Val Lys Asp Arg Cys Leu Phe Ala
        1075                1080                1085
Ser Phe Leu Thr Ile Ala Leu Gln Thr Lys Leu Val Tyr Leu Thr Ser
    1090                1095                1100
Ile Leu Glu Val Leu Thr Arg Asp Leu Met Glu Gln Cys Ser Asn Met
1105                1110                1115                1120
Gln Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys Leu
                1125                1130                1135
Leu Thr Asn Trp Met Ser Val Cys Leu Ser Gly Phe Leu Arg Glu Thr
            1140                1145                1150
Val Gly Glu Pro Phe Tyr Leu Leu Val Thr Thr Leu Asn Gln Lys Ile
        1155                1160                1165
Asn Lys Gly Pro Val Asp Val Ile Thr Cys Lys Ala Leu Tyr Thr Leu
    1170                1175                1180
Asn Glu Asp Trp Leu Leu Trp Gln Val Pro Glu Phe Ser Thr Val Ala
1185                1190                1195                1200
Leu Asn Val Val Phe Glu Lys Ile Pro Glu Asn Glu Ser Ala Asp Val
                1205                1210                1215
Cys Arg Asn Ile Ser Val Asn Val Leu Asp Cys Asp Thr Ile Gly Gln
            1220                1225                1230
Ala Lys Glu Lys Ile Phe Gln Ala Phe Leu Ser Lys Asn Gly Ser Pro
        1235                1240                1245
Tyr Gly Leu Gln Leu Asn Glu Ile Gly Leu Glu Leu Gln Met Gly Thr
    1250                1255                1260
Arg Gln Lys Glu Leu Leu Asp Ile Asp Ser Ser Ser Val Ile Leu Glu
1265                1270                1275                1280
Asp Gly Ile Thr Lys Leu Asn Thr Ile Gly His Tyr Glu Ile Ser Asn
                1285                1290                1295
Gly Ser Thr Ile Lys Val Phe Lys Lys Ile Ala Asn Phe Thr Ser Asp
            1300                1305                1310
Val Glu Tyr Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu
        1315                1320                1325
Ala Phe Gln Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe
    1330                1335                1340
Lys Val Lys Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Val Ala
1345                1350                1355                1360
Ile His Ser Val Leu Glu Lys Leu Phe Arg Ser Ile Trp Ser Leu Pro
                1365                1370                1375
Asn Ser Arg Ala Pro Phe Ala Ile Lys Tyr Phe Phe Asp Phe Leu Asp
            1380                1385                1390
Ala Gln Ala Glu Asn Lys Lys Ile Thr Asp Pro Asp Val Val His Ile
        1395                1400                1405
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys
    1410                1415                1420
Asn Pro Gln Phe Val Phe Asp Ile Lys Lys Thr Pro His Ile Asp Gly
1425                1430                1435                1440
Cys Leu Ser Val Ile Ala Gln Ala Phe Met Asp Ala Phe Ser Leu Thr
                1445                1450                1455
Glu Gln Gln Leu Gly Lys Glu Ala Pro Thr Asn Lys Leu Leu Tyr Ala
            1460                1465                1470
Lys Asp Ile Pro Thr Tyr Lys Glu Glu Val Lys Ser Tyr Tyr Lys Ala
        1475                1480                1485
Ile Arg Asp Leu Pro Pro Leu Ser Ser Ser Glu Met Glu Glu Phe Leu
    1490                1495                1500
Thr Gln Glu Ser Lys Lys His Glu Asn Glu Phe Asn Glu Glu Val Ala
1505                1510                1515                1520
Leu Thr Glu Ile Tyr Lys Tyr Ile Val Lys Tyr Phe Asp Glu Ile Leu
                1525                1530                1535
Asn Lys Leu Glu Arg Glu Arg Gly Leu Glu Glu Ala Gln Lys Gln Leu
            1540                1545                1550
Leu His Val Lys Val Leu Phe Asp Glu Lys Lys Lys Cys Lys Trp Met
        1555                1560                1565

<210> 1057
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 1057
Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala
 1               5                  10                  15
Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly
            20                  25                  30
Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala
        35                  40                  45
Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys
    50                  55                  60
Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr
65                  70                  75                  80
Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro
                85                  90                  95
Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr
            100                 105                 110
Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr
        115                 120                 125
Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg
    130                 135                 140
Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly
145                 150                 155                 160
Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr
                165                 170                 175
Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser
            180                 185                 190
Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys
        195                 200                 205
Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys
    210                 215                 220
Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp
225                 230                 235                 240
Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly
                245                 250                 255
Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu
            260                 265                 270
Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro
        275                 280                 285
Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp
    290                 295                 300
Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg
305                 310                 315                 320
Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile
                325                 330                 335
Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser
            340                 345                 350
His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser
        355                 360                 365
Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val
    370                 375                 380
Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu
385                 390                 395                 400
Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile
                405                 410                 415
Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp
            420                 425                 430
Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg
        435                 440                 445
Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys
    450                 455                 460
Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg
465                 470                 475                 480
Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp
                485                 490                 495
Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile
            500                 505                 510
Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser
        515                 520                 525
Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu
    530                 535                 540
Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile
545                 550                 555                 560
Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe
                565                 570                 575
Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys
            580                 585                 590
Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp
        595                 600                 605
Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro
    610                 615                 620
Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys
625                 630                 635                 640
Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn
                645                 650                 655
Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val
            660                 665                 670
Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr
        675                 680                 685
Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp
    690                 695                 700
Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys
705                 710                 715                 720
Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln
                725                 730                 735
Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala
            740                 745                 750
Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly
        755                 760                 765
Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn
    770                 775                 780
Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr
785                 790                 795                 800
Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser
                805                 810                 815
Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr
            820                 825                 830
Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly
        835                 840                 845
Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln
    850                 855                 860
Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr
865                 870                 875                 880
Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile
                885                 890                 895
Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile
            900                 905                 910
Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys
        915                 920                 925
Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr
    930                 935                 940
Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe
945                 950                 955                 960
Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys
                965                 970                 975
Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile
            980                 985                 990
Arg Asp Gly Phe Ala Glu Leu Gln Met Asp Lys Leu Asp Val Val Asp
        995                 1000                1005
Ser Phe Gly Thr Val Pro Phe Leu Asp Tyr Lys His Phe Ala Leu Arg
    1010                1015                1020
Thr Phe Phe Pro Glu Ser Gly Gly Phe Thr His Ile Phe Thr Glu Asp
1025                1030                1035                1040
Met His Asn Arg Asp Ala Asn Asp Lys Asn Glu Ser Leu Thr Ala Leu
                1045                1050                1055
Asp Ala Leu Ile Cys Asn Lys Ser Phe Leu Val Thr Val Ile His Thr
            1060                1065                1070
Leu Glu Lys Gln Lys Asn Phe Ser Val Lys Asp Arg Cys Leu Phe Ala
        1075                1080                1085
Ser Phe Leu Thr Ile Ala Leu Gln Thr Lys Leu Val Tyr Leu Thr Ser
    1090                1095                1100
Ile Leu Glu Val Leu Thr Arg Asp Leu Met Glu Gln Cys Ser Asn Met
1105                1110                1115                1120
Gln Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys Leu
                1125                1130                1135
Leu Thr Asn Trp Met Ser Val Cys Leu Ser Gly Phe Leu Arg Glu Thr
            1140                1145                1150
Val Gly Glu Pro Phe Tyr Leu Leu Val Thr Thr Leu Asn Gln Lys Ile
        1155                1160                1165
Asn Lys Gly Pro Val Asp Val Ile Thr Cys Lys Ala Leu Tyr Thr Leu
    1170                1175                1180
Asn Glu Asp Trp Leu Leu Trp Gln Val Pro Glu Phe Ser Thr Val Ala
1185                1190                1195                1200
Leu Asn Val Val Phe Glu Lys Ile Pro Glu Asn Glu Ser Ala Asp Val
                1205                1210                1215
Cys Arg Asn Ile Ser Val Asn Val Leu Asp Cys Asp Thr Ile Gly Gln
            1220                1225                1230
Ala Lys Glu Lys Ile Phe Gln Ala Phe Leu Ser Lys Asn Gly Ser Pro
        1235                1240                1245
Tyr Gly Leu Gln Leu Asn Glu Ile Gly Leu Glu Leu Gln Met Gly Thr
    1250                1255                1260
Arg Gln Lys Glu Leu Leu Asp Ile Asp Ser Ser Ser Val Ile Leu Glu
1265                1270                1275                1280
Asp Gly Ile Thr Lys Leu Asn Thr Ile Gly His Tyr Glu Ile Ser Asn
                1285                1290                1295
Gly Ser Thr Ile Lys Val Phe Lys Lys Ile Ala Asn Phe Thr Ser Asp
            1300                1305                1310
Val Glu Tyr Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu
        1315                1320                1325
Ala Phe Gln Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe
    1330                1335                1340
Lys Val Lys Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Val Ala
1345                1350                1355                1360
Ile His Ser Val Leu Glu Lys Leu Phe Arg Ser Ile Trp Ser Leu Pro
                1365                1370                1375
Asn Ser Arg Ala Pro Phe Ala Ile Lys Tyr Phe Phe Asp Phe Leu Asp
            1380                1385                1390
Ala Gln Ala Glu Asn Lys Lys Ile Thr Asp Pro Asp Val Val His Ile
        1395                1400                1405
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys
    1410                1415                1420
Asn Pro Gln Phe Val Phe Asp Ile Lys Lys Thr Pro His Ile Asp Gly
1425                1430                1435                1440
Cys Leu Ser Val Ile Ala Gln Ala Phe Met Asp Ala Phe Ser Leu Thr
                1445                1450                1455
Glu Gln Gln Leu Gly Lys Glu Ala Pro Thr Asn Lys Leu Leu Tyr Ala
            1460                1465                1470
Lys Asp Ile Pro Thr Tyr Lys Glu Glu Val Lys Ser Tyr Tyr Lys Ala
        1475                1480                1485
Ile Arg Asp Leu Pro Pro Leu Ser Ser Ser Glu Met Glu Glu Phe Leu
    1490                1495                1500
Thr Gln Glu Ser Lys Lys His Glu Asn Glu Phe Asn Glu Glu Val Ala
1505                1510                1515                1520
Leu Thr Glu Ile Tyr Lys Tyr Ile Val Lys Tyr Phe Asp Glu Ile Leu
                1525                1530                1535
Asn Lys Leu Glu Arg Glu Arg Gly Leu Glu Glu Ala Gln Lys Gln Leu
            1540                1545                1550
Leu His Val Lys Val Leu Phe Asp Glu Lys Lys Lys Cys Lys Trp Met
        1555                1560                1565

<210> 1058
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 1058
Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala
 1               5                  10                  15
Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly
            20                  25                  30
Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala
        35                  40                  45
Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys
    50                  55                  60
Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr
65                  70                  75                  80
Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro
                85                  90                  95
Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr
            100                 105                 110
Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr
        115                 120                 125
Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg
    130                 135                 140
Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly
145                 150                 155                 160
Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr
                165                 170                 175
Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser
            180                 185                 190
Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys
        195                 200                 205
Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys
    210                 215                 220
Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp
225                 230                 235                 240
Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly
                245                 250                 255
Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu
            260                 265                 270
Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro
        275                 280                 285
Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp
    290                 295                 300
Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg
305                 310                 315                 320
Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile
                325                 330                 335
Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser
            340                 345                 350
His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser
        355                 360                 365
Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val
    370                 375                 380
Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu
385                 390                 395                 400
Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile
                405                 410                 415
Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp
            420                 425                 430
Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg
        435                 440                 445
Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys
    450                 455                 460
Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg
465                 470                 475                 480
Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp
                485                 490                 495
Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile
            500                 505                 510
Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser
        515                 520                 525
Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu
    530                 535                 540
Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile
545                 550                 555                 560
Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe
                565                 570                 575
Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys
            580                 585                 590
Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp
        595                 600                 605
Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro
    610                 615                 620
Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys
625                 630                 635                 640
Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn
                645                 650                 655
Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val
            660                 665                 670
Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr
        675                 680                 685
Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp
    690                 695                 700
Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys
705                 710                 715                 720
Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln
                725                 730                 735
Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala
            740                 745                 750
Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly
        755                 760                 765
Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn
    770                 775                 780
Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr
785                 790                 795                 800
Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser
                805                 810                 815
Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr
            820                 825                 830
Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly
        835                 840                 845
Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln
    850                 855                 860
Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr
865                 870                 875                 880
Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile
                885                 890                 895
Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile
            900                 905                 910
Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys
        915                 920                 925
Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr
    930                 935                 940
Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe
945                 950                 955                 960
Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys
                965                 970                 975
Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile
            980                 985                 990
Arg Asp Gly Phe Ala Glu Leu Gln Met Asp Lys Leu Asp Val Val Asp
        995                 1000                1005
Ser Phe Gly Thr Val Pro Phe Leu Asp Tyr Lys His Phe Ala Leu Arg
    1010                1015                1020
Thr Phe Phe Pro Glu Ser Gly Gly Phe Thr His Ile Phe Thr Glu Asp
1025                1030                1035                1040
Met His Asn Arg Asp Ala Asn Asp Lys Asn Glu Ser Leu Thr Ala Leu
                1045                1050                1055
Asp Ala Leu Ile Cys Asn Lys Ser Phe Leu Val Thr Val Ile His Thr
            1060                1065                1070
Leu Glu Lys Gln Lys Asn Phe Ser Val Lys Asp Arg Cys Leu Phe Ala
        1075                1080                1085
Ser Phe Leu Thr Ile Ala Leu Gln Thr Lys Leu Val Tyr Leu Thr Ser
    1090                1095                1100
Ile Leu Glu Val Leu Thr Arg Asp Leu Met Glu Gln Cys Ser Asn Met
1105                1110                1115                1120
Gln Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys Leu
                1125                1130                1135
Leu Thr Asn Trp Met Ser Val Cys Leu Ser Gly Phe Leu Arg Glu Thr
            1140                1145                1150
Val Gly Glu Pro Phe Tyr Leu Leu Val Thr Thr Leu Asn Gln Lys Ile
        1155                1160                1165
Asn Lys Gly Pro Val Asp Val Ile Thr Cys Lys Ala Leu Tyr Thr Leu
    1170                1175                1180
Asn Glu Asp Trp Leu Leu Trp Gln Val Pro Glu Phe Ser Thr Val Ala
1185                1190                1195                1200
Leu Asn Val Val Phe Glu Lys Ile Pro Glu Asn Glu Ser Ala Asp Val
                1205                1210                1215
Cys Arg Asn Ile Ser Val Asn Val Leu Asp Cys Asp Thr Ile Gly Gln
            1220                1225                1230
Ala Lys Glu Lys Ile Phe Gln Ala Phe Leu Ser Lys Asn Gly Ser Pro
        1235                1240                1245
Tyr Gly Leu Gln Leu Asn Glu Ile Gly Leu Glu Leu Gln Met Gly Thr
    1250                1255                1260
Arg Gln Lys Glu Leu Leu Asp Ile Asp Ser Ser Ser Val Ile Leu Glu
1265                1270                1275                1280
Asp Gly Ile Thr Lys Leu Asn Thr Ile Gly His Tyr Glu Ile Ser Asn
                1285                1290                1295
Gly Ser Thr Ile Lys Val Phe Lys Lys Ile Ala Asn Phe Thr Ser Asp
            1300                1305                1310
Val Glu Tyr Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu
        1315                1320                1325
Ala Phe Gln Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe
    1330                1335                1340
Lys Val Lys Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Val Ala
1345                1350                1355                1360
Ile His Ser Val Leu Glu Lys Leu Phe Arg Ser Ile Trp Ser Leu Pro
                1365                1370                1375
Asn Ser Arg Ala Pro Phe Ala Ile Lys Tyr Phe Phe Asp Phe Leu Asp
            1380                1385                1390
Ala Gln Ala Glu Asn Lys Lys Ile Thr Asp Pro Asp Val Val His Ile
        1395                1400                1405
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys
    1410                1415                1420
Asn Pro Gln Phe Val Phe Asp Ile Lys Lys Thr Pro His Ile Asp Gly
1425                1430                1435                1440
Cys Leu Ser Val Ile Ala Gln Ala Phe Met Asp Ala Phe Ser Leu Thr
                1445                1450                1455
Glu Gln Gln Leu Gly Lys Glu Ala Pro Thr Asn Lys Leu Leu Tyr Ala
            1460                1465                1470
Lys Asp Ile Pro Thr Tyr Lys Glu Glu Val Lys Ser Tyr Tyr Lys Ala
        1475                1480                1485
Ile Arg Asp Leu Pro Pro Leu Ser Ser Ser Glu Met Glu Glu Phe Leu
    1490                1495                1500
Thr Gln Glu Ser Lys Lys His Glu Asn Glu Phe Asn Glu Glu Val Ala
1505                1510                1515                1520
Leu Thr Glu Ile Tyr Lys Tyr Ile Val Lys Tyr Phe Asp Glu Ile Leu
                1525                1530                1535
Asn Lys Leu Glu Arg Glu Arg Gly Leu Glu Glu Ala Gln Lys Gln Leu
            1540                1545                1550
Leu His Val Lys Val Leu Phe Asp Glu Lys Lys Lys Cys Lys Trp Met
        1555                1560                1565

<210> 1059
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 1059
Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala
 1               5                  10                  15
Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly
            20                  25                  30
Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala
        35                  40                  45
Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys
    50                  55                  60
Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr
65                  70                  75                  80
Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro
                85                  90                  95
Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr
            100                 105                 110
Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr
        115                 120                 125
Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg
    130                 135                 140
Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly
145                 150                 155                 160
Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr
                165                 170                 175
Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser
            180                 185                 190
Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys
        195                 200                 205
Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys
    210                 215                 220
Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp
225                 230                 235                 240
Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly
                245                 250                 255
Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu
            260                 265                 270
Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro
        275                 280                 285
Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp
    290                 295                 300
Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg
305                 310                 315                 320
Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile
                325                 330                 335
Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser
            340                 345                 350
His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser
        355                 360                 365
Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val
    370                 375                 380
Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu
385                 390                 395                 400
Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile
                405                 410                 415
Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp
            420                 425                 430
Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg
        435                 440                 445
Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys
    450                 455                 460
Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg
465                 470                 475                 480
Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp
                485                 490                 495
Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile
            500                 505                 510
Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser
        515                 520                 525
Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu
    530                 535                 540
Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile
545                 550                 555                 560
Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe
                565                 570                 575
Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys
            580                 585                 590
Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp
        595                 600                 605
Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro
    610                 615                 620
Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys
625                 630                 635                 640
Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn
                645                 650                 655
Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val
            660                 665                 670
Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr
        675                 680                 685
Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp
    690                 695                 700
Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys
705                 710                 715                 720
Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln
                725                 730                 735
Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala
            740                 745                 750
Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly
        755                 760                 765
Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn
    770                 775                 780
Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr
785                 790                 795                 800
Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser
                805                 810                 815
Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr
            820                 825                 830
Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly
        835                 840                 845
Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln
    850                 855                 860
Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr
865                 870                 875                 880
Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile
                885                 890                 895
Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile
            900                 905                 910
Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys
        915                 920                 925
Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr
    930                 935                 940
Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe
945                 950                 955                 960
Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys
                965                 970                 975
Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile
            980                 985                 990
Arg Asp Gly Phe Ala Glu Leu Gln Met Asp Lys Leu Asp Val Val Asp
        995                 1000                1005
Ser Phe Gly Thr Val Pro Phe Leu Asp Tyr Lys His Phe Ala Leu Arg
    1010                1015                1020
Thr Phe Phe Pro Glu Ser Gly Gly Phe Thr His Ile Phe Thr Glu Asp
1025                1030                1035                1040
Met His Asn Arg Asp Ala Asn Asp Lys Asn Glu Ser Leu Thr Ala Leu
                1045                1050                1055
Asp Ala Leu Ile Cys Asn Lys Ser Phe Leu Val Thr Val Ile His Thr
            1060                1065                1070
Leu Glu Lys Gln Lys Asn Phe Ser Val Lys Asp Arg Cys Leu Phe Ala
        1075                1080                1085
Ser Phe Leu Thr Ile Ala Leu Gln Thr Lys Leu Val Tyr Leu Thr Ser
    1090                1095                1100
Ile Leu Glu Val Leu Thr Arg Asp Leu Met Glu Gln Cys Ser Asn Met
1105                1110                1115                1120
Gln Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys Leu
                1125                1130                1135
Leu Thr Asn Trp Met Ser Val Cys Leu Ser Gly Phe Leu Arg Glu Thr
            1140                1145                1150
Val Gly Glu Pro Phe Tyr Leu Leu Val Thr Thr Leu Asn Gln Lys Ile
        1155                1160                1165
Asn Lys Gly Pro Val Asp Val Ile Thr Cys Lys Ala Leu Tyr Thr Leu
    1170                1175                1180
Asn Glu Asp Trp Leu Leu Trp Gln Val Pro Glu Phe Ser Thr Val Ala
1185                1190                1195                1200
Leu Asn Val Val Phe Glu Lys Ile Pro Glu Asn Glu Ser Ala Asp Val
                1205                1210                1215
Cys Arg Asn Ile Ser Val Asn Val Leu Asp Cys Asp Thr Ile Gly Gln
            1220                1225                1230
Ala Lys Glu Lys Ile Phe Gln Ala Phe Leu Ser Lys Asn Gly Ser Pro
        1235                1240                1245
Tyr Gly Leu Gln Leu Asn Glu Ile Gly Leu Glu Leu Gln Met Gly Thr
    1250                1255                1260
Arg Gln Lys Glu Leu Leu Asp Ile Asp Ser Ser Ser Val Ile Leu Glu
1265                1270                1275                1280
Asp Gly Ile Thr Lys Leu Asn Thr Ile Gly His Tyr Glu Ile Ser Asn
                1285                1290                1295
Gly Ser Thr Ile Lys Val Phe Lys Lys Ile Ala Asn Phe Thr Ser Asp
            1300                1305                1310
Val Glu Tyr Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu
        1315                1320                1325
Ala Phe Gln Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe
    1330                1335                1340
Lys Val Lys Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Val Ala
1345                1350                1355                1360
Ile His Ser Val Leu Glu Lys Leu Phe Arg Ser Ile Trp Ser Leu Pro
                1365                1370                1375
Asn Ser Arg Ala Pro Phe Ala Ile Lys Tyr Phe Phe Asp Phe Leu Asp
            1380                1385                1390
Ala Gln Ala Glu Asn Lys Lys Ile Thr Asp Pro Asp Val Val His Ile
        1395                1400                1405
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys
    1410                1415                1420
Asn Pro Gln Phe Val Phe Asp Ile Lys Lys Thr Pro His Ile Asp Gly
1425                1430                1435                1440
Cys Leu Ser Val Ile Ala Gln Ala Phe Met Asp Ala Phe Ser Leu Thr
                1445                1450                1455
Glu Gln Gln Leu Gly Lys Glu Ala Pro Thr Asn Lys Leu Leu Tyr Ala
            1460                1465                1470
Lys Asp Ile Pro Thr Tyr Lys Glu Glu Val Lys Ser Tyr Tyr Lys Ala
        1475                1480                1485
Ile Arg Asp Leu Pro Pro Leu Ser Ser Ser Glu Met Glu Glu Phe Leu
    1490                1495                1500
Thr Gln Glu Ser Lys Lys His Glu Asn Glu Phe Asn Glu Glu Val Ala
1505                1510                1515                1520
Leu Thr Glu Ile Tyr Lys Tyr Ile Val Lys Tyr Phe Asp Glu Ile Leu
                1525                1530                1535
Asn Lys Leu Glu Arg Glu Arg Gly Leu Glu Glu Ala Gln Lys Gln Leu
            1540                1545                1550
Leu His Val Lys Val Leu Phe Asp Glu Lys Lys Lys Cys Lys Trp Met
        1555                1560                1565

<210> 1060
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 1060
Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala
 1               5                  10                  15
Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly
            20                  25                  30
Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala
        35                  40                  45
Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys
    50                  55                  60
Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr
65                  70                  75                  80
Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro
                85                  90                  95
Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr
            100                 105                 110
Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr
        115                 120                 125
Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg
    130                 135                 140
Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly
145                 150                 155                 160
Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr
                165                 170                 175
Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser
            180                 185                 190
Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys
        195                 200                 205
Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys
    210                 215                 220
Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp
225                 230                 235                 240
Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly
                245                 250                 255
Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu
            260                 265                 270
Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro
        275                 280                 285
Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp
    290                 295                 300
Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg
305                 310                 315                 320
Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile
                325                 330                 335
Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser
            340                 345                 350
His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser
        355                 360                 365
Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val
    370                 375                 380
Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu
385                 390                 395                 400
Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile
                405                 410                 415
Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp
            420                 425                 430
Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg
        435                 440                 445
Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys
    450                 455                 460
Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg
465                 470                 475                 480
Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp
                485                 490                 495
Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile
            500                 505                 510
Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser
        515                 520                 525
Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu
    530                 535                 540
Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile
545                 550                 555                 560
Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe
                565                 570                 575
Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys
            580                 585                 590
Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp
        595                 600                 605
Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro
    610                 615                 620
Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys
625                 630                 635                 640
Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn
                645                 650                 655
Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val
            660                 665                 670
Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr
        675                 680                 685
Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp
    690                 695                 700
Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys
705                 710                 715                 720
Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln
                725                 730                 735
Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala
            740                 745                 750
Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly
        755                 760                 765
Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn
    770                 775                 780
Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr
785                 790                 795                 800
Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser
                805                 810                 815
Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr
            820                 825                 830
Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly
        835                 840                 845
Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln
    850                 855                 860
Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr
865                 870                 875                 880
Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile
                885                 890                 895
Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile
            900                 905                 910
Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys
        915                 920                 925
Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr
    930                 935                 940
Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe
945                 950                 955                 960
Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys
                965                 970                 975
Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile
            980                 985                 990
Arg Asp Gly Phe Ala Glu Leu Gln Met Asp Lys Leu Asp Val Val Asp
        995                 1000                1005
Ser Phe Gly Thr Val Pro Phe Leu Asp Tyr Lys His Phe Ala Leu Arg
    1010                1015                1020
Thr Phe Phe Pro Glu Ser Gly Gly Phe Thr His Ile Phe Thr Glu Asp
1025                1030                1035                1040
Met His Asn Arg Asp Ala Asn Asp Lys Asn Glu Ser Leu Thr Ala Leu
                1045                1050                1055
Asp Ala Leu Ile Cys Asn Lys Ser Phe Leu Val Thr Val Ile His Thr
            1060                1065                1070
Leu Glu Lys Gln Lys Asn Phe Ser Val Lys Asp Arg Cys Leu Phe Ala
        1075                1080                1085
Ser Phe Leu Thr Ile Ala Leu Gln Thr Lys Leu Val Tyr Leu Thr Ser
    1090                1095                1100
Ile Leu Glu Val Leu Thr Arg Asp Leu Met Glu Gln Cys Ser Asn Met
1105                1110                1115                1120
Gln Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys Leu
                1125                1130                1135
Leu Thr Asn Trp Met Ser Val Cys Leu Ser Gly Phe Leu Arg Glu Thr
            1140                1145                1150
Val Gly Glu Pro Phe Tyr Leu Leu Val Thr Thr Leu Asn Gln Lys Ile
        1155                1160                1165
Asn Lys Gly Pro Val Asp Val Ile Thr Cys Lys Ala Leu Tyr Thr Leu
    1170                1175                1180
Asn Glu Asp Trp Leu Leu Trp Gln Val Pro Glu Phe Ser Thr Val Ala
1185                1190                1195                1200
Leu Asn Val Val Phe Glu Lys Ile Pro Glu Asn Glu Ser Ala Asp Val
                1205                1210                1215
Cys Arg Asn Ile Ser Val Asn Val Leu Asp Cys Asp Thr Ile Gly Gln
            1220                1225                1230
Ala Lys Glu Lys Ile Phe Gln Ala Phe Leu Ser Lys Asn Gly Ser Pro
        1235                1240                1245
Tyr Gly Leu Gln Leu Asn Glu Ile Gly Leu Glu Leu Gln Met Gly Thr
    1250                1255                1260
Arg Gln Lys Glu Leu Leu Asp Ile Asp Ser Ser Ser Val Ile Leu Glu
1265                1270                1275                1280
Asp Gly Ile Thr Lys Leu Asn Thr Ile Gly His Tyr Glu Ile Ser Asn
                1285                1290                1295
Gly Ser Thr Ile Lys Val Phe Lys Lys Ile Ala Asn Phe Thr Ser Asp
            1300                1305                1310
Val Glu Tyr Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu
        1315                1320                1325
Ala Phe Gln Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe
    1330                1335                1340
Lys Val Lys Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Val Ala
1345                1350                1355                1360
Ile His Ser Val Leu Glu Lys Leu Phe Arg Ser Ile Trp Ser Leu Pro
                1365                1370                1375
Asn Ser Arg Ala Pro Phe Ala Ile Lys Tyr Phe Phe Asp Phe Leu Asp
            1380                1385                1390
Ala Gln Ala Glu Asn Lys Lys Ile Thr Asp Pro Asp Val Val His Ile
        1395                1400                1405
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys
    1410                1415                1420
Asn Pro Gln Phe Val Phe Asp Ile Lys Lys Thr Pro His Ile Asp Gly
1425                1430                1435                1440
Cys Leu Ser Val Ile Ala Gln Ala Phe Met Asp Ala Phe Ser Leu Thr
                1445                1450                1455
Glu Gln Gln Leu Gly Lys Glu Ala Pro Thr Asn Lys Leu Leu Tyr Ala
            1460                1465                1470
Lys Asp Ile Pro Thr Tyr Lys Glu Glu Val Lys Ser Tyr Tyr Lys Ala
        1475                1480                1485
Ile Arg Asp Leu Pro Pro Leu Ser Ser Ser Glu Met Glu Glu Phe Leu
    1490                1495                1500
Thr Gln Glu Ser Lys Lys His Glu Asn Glu Phe Asn Glu Glu Val Ala
1505                1510                1515                1520
Leu Thr Glu Ile Tyr Lys Tyr Ile Val Lys Tyr Phe Asp Glu Ile Leu
                1525                1530                1535
Asn Lys Leu Glu Arg Glu Arg Gly Leu Glu Glu Ala Gln Lys Gln Leu
            1540                1545                1550
Leu His Val Lys Val Leu Phe Asp Glu Lys Lys Lys Cys Lys Trp Met
        1555                1560                1565

<210> 1061
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 1061
Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala
 1               5                  10                  15
Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly
            20                  25                  30
Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala
        35                  40                  45
Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys
    50                  55                  60
Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr
65                  70                  75                  80
Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro
                85                  90                  95
Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr
            100                 105                 110
Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr
        115                 120                 125
Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg
    130                 135                 140
Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly
145                 150                 155                 160
Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr
                165                 170                 175
Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser
            180                 185                 190
Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys
        195                 200                 205
Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys
    210                 215                 220
Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp
225                 230                 235                 240
Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly
                245                 250                 255
Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu
            260                 265                 270
Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro
        275                 280                 285
Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp
    290                 295                 300
Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg
305                 310                 315                 320
Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile
                325                 330                 335
Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser
            340                 345                 350
His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser
        355                 360                 365
Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val
    370                 375                 380
Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu
385                 390                 395                 400
Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile
                405                 410                 415
Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp
            420                 425                 430
Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg
        435                 440                 445
Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys
    450                 455                 460
Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg
465                 470                 475                 480
Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp
                485                 490                 495
Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile
            500                 505                 510
Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser
        515                 520                 525
Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu
    530                 535                 540
Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile
545                 550                 555                 560
Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe
                565                 570                 575
Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys
            580                 585                 590
Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp
        595                 600                 605
Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro
    610                 615                 620
Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys
625                 630                 635                 640
Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn
                645                 650                 655
Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val
            660                 665                 670
Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr
        675                 680                 685
Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp
    690                 695                 700
Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys
705                 710                 715                 720
Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln
                725                 730                 735
Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala
            740                 745                 750
Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly
        755                 760                 765
Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn
    770                 775                 780
Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr
785                 790                 795                 800
Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser
                805                 810                 815
Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr
            820                 825                 830
Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly
        835                 840                 845
Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln
    850                 855                 860
Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr
865                 870                 875                 880
Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile
                885                 890                 895
Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile
            900                 905                 910
Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys
        915                 920                 925
Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr
    930                 935                 940
Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe
945                 950                 955                 960
Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys
                965                 970                 975
Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile
            980                 985                 990
Arg Asp Gly Phe Ala Glu Leu Gln Met Asp Lys Leu Asp Val Val Asp
        995                 1000                1005
Ser Phe Gly Thr Val Pro Phe Leu Asp Tyr Lys His Phe Ala Leu Arg
    1010                1015                1020
Thr Phe Phe Pro Glu Ser Gly Gly Phe Thr His Ile Phe Thr Glu Asp
1025                1030                1035                1040
Met His Asn Arg Asp Ala Asn Asp Lys Asn Glu Ser Leu Thr Ala Leu
                1045                1050                1055
Asp Ala Leu Ile Cys Asn Lys Ser Phe Leu Val Thr Val Ile His Thr
            1060                1065                1070
Leu Glu Lys Gln Lys Asn Phe Ser Val Lys Asp Arg Cys Leu Phe Ala
        1075                1080                1085
Ser Phe Leu Thr Ile Ala Leu Gln Thr Lys Leu Val Tyr Leu Thr Ser
    1090                1095                1100
Ile Leu Glu Val Leu Thr Arg Asp Leu Met Glu Gln Cys Ser Asn Met
1105                1110                1115                1120
Gln Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys Leu
                1125                1130                1135
Leu Thr Asn Trp Met Ser Val Cys Leu Ser Gly Phe Leu Arg Glu Thr
            1140                1145                1150
Val Gly Glu Pro Phe Tyr Leu Leu Val Thr Thr Leu Asn Gln Lys Ile
        1155                1160                1165
Asn Lys Gly Pro Val Asp Val Ile Thr Cys Lys Ala Leu Tyr Thr Leu
    1170                1175                1180
Asn Glu Asp Trp Leu Leu Trp Gln Val Pro Glu Phe Ser Thr Val Ala
1185                1190                1195                1200
Leu Asn Val Val Phe Glu Lys Ile Pro Glu Asn Glu Ser Ala Asp Val
                1205                1210                1215
Cys Arg Asn Ile Ser Val Asn Val Leu Asp Cys Asp Thr Ile Gly Gln
            1220                1225                1230
Ala Lys Glu Lys Ile Phe Gln Ala Phe Leu Ser Lys Asn Gly Ser Pro
        1235                1240                1245
Tyr Gly Leu Gln Leu Asn Glu Ile Gly Leu Glu Leu Gln Met Gly Thr
    1250                1255                1260
Arg Gln Lys Glu Leu Leu Asp Ile Asp Ser Ser Ser Val Ile Leu Glu
1265                1270                1275                1280
Asp Gly Ile Thr Lys Leu Asn Thr Ile Gly His Tyr Glu Ile Ser Asn
                1285                1290                1295
Gly Ser Thr Ile Lys Val Phe Lys Lys Ile Ala Asn Phe Thr Ser Asp
            1300                1305                1310
Val Glu Tyr Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu
        1315                1320                1325
Ala Phe Gln Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe
    1330                1335                1340
Lys Val Lys Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Val Ala
1345                1350                1355                1360
Ile His Ser Val Leu Glu Lys Leu Phe Arg Ser Ile Trp Ser Leu Pro
                1365                1370                1375
Asn Ser Arg Ala Pro Phe Ala Ile Lys Tyr Phe Phe Asp Phe Leu Asp
            1380                1385                1390
Ala Gln Ala Glu Asn Lys Lys Ile Thr Asp Pro Asp Val Val His Ile
        1395                1400                1405
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys
    1410                1415                1420
Asn Pro Gln Phe Val Phe Asp Ile Lys Lys Thr Pro His Ile Asp Gly
1425                1430                1435                1440
Cys Leu Ser Val Ile Ala Gln Ala Phe Met Asp Ala Phe Ser Leu Thr
                1445                1450                1455
Glu Gln Gln Leu Gly Lys Glu Ala Pro Thr Asn Lys Leu Leu Tyr Ala
            1460                1465                1470
Lys Asp Ile Pro Thr Tyr Lys Glu Glu Val Lys Ser Tyr Tyr Lys Ala
        1475                1480                1485
Ile Arg Asp Leu Pro Pro Leu Ser Ser Ser Glu Met Glu Glu Phe Leu
    1490                1495                1500
Thr Gln Glu Ser Lys Lys His Glu Asn Glu Phe Asn Glu Glu Val Ala
1505                1510                1515                1520
Leu Thr Glu Ile Tyr Lys Tyr Ile Val Lys Tyr Phe Asp Glu Ile Leu
                1525                1530                1535
Asn Lys Leu Glu Arg Glu Arg Gly Leu Glu Glu Ala Gln Lys Gln Leu
            1540                1545                1550
Leu His Val Lys Val Leu Phe Asp Glu Lys Lys Lys Cys Lys Trp Met
        1555                1560                1565

<210> 1062
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 1062
Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala
 1               5                  10                  15
Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly
            20                  25                  30
Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala
        35                  40                  45
Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys
    50                  55                  60
Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr
65                  70                  75                  80
Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro
                85                  90                  95
Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr
            100                 105                 110
Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr
        115                 120                 125
Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg
    130                 135                 140
Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly
145                 150                 155                 160
Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr
                165                 170                 175
Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser
            180                 185                 190
Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys
        195                 200                 205
Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys
    210                 215                 220
Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp
225                 230                 235                 240
Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly
                245                 250                 255
Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu
            260                 265                 270
Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro
        275                 280                 285
Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp
    290                 295                 300
Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg
305                 310                 315                 320
Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile
                325                 330                 335
Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser
            340                 345                 350
His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser
        355                 360                 365
Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val
    370                 375                 380
Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu
385                 390                 395                 400
Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile
                405                 410                 415
Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp
            420                 425                 430
Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg
        435                 440                 445
Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys
    450                 455                 460
Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg
465                 470                 475                 480
Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp
                485                 490                 495
Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile
            500                 505                 510
Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser
        515                 520                 525
Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu
    530                 535                 540
Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile
545                 550                 555                 560
Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe
                565                 570                 575
Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys
            580                 585                 590
Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp
        595                 600                 605
Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro
    610                 615                 620
Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys
625                 630                 635                 640
Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn
                645                 650                 655
Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val
            660                 665                 670
Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr
        675                 680                 685
Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp
    690                 695                 700
Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys
705                 710                 715                 720
Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln
                725                 730                 735
Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala
            740                 745                 750
Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly
        755                 760                 765
Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn
    770                 775                 780
Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr
785                 790                 795                 800
Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser
                805                 810                 815
Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr
            820                 825                 830
Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly
        835                 840                 845
Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln
    850                 855                 860
Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr
865                 870                 875                 880
Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile
                885                 890                 895
Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile
            900                 905                 910
Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys
        915                 920                 925
Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr
    930                 935                 940
Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe
945                 950                 955                 960
Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys
                965                 970                 975
Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile
            980                 985                 990
Arg Asp Gly Phe Ala Glu Leu Gln Met Asp Lys Leu Asp Val Val Asp
        995                 1000                1005
Ser Phe Gly Thr Val Pro Phe Leu Asp Tyr Lys His Phe Ala Leu Arg
    1010                1015                1020
Thr Phe Phe Pro Glu Ser Gly Gly Phe Thr His Ile Phe Thr Glu Asp
1025                1030                1035                1040
Met His Asn Arg Asp Ala Asn Asp Lys Asn Glu Ser Leu Thr Ala Leu
                1045                1050                1055
Asp Ala Leu Ile Cys Asn Lys Ser Phe Leu Val Thr Val Ile His Thr
            1060                1065                1070
Leu Glu Lys Gln Lys Asn Phe Ser Val Lys Asp Arg Cys Leu Phe Ala
        1075                1080                1085
Ser Phe Leu Thr Ile Ala Leu Gln Thr Lys Leu Val Tyr Leu Thr Ser
    1090                1095                1100
Ile Leu Glu Val Leu Thr Arg Asp Leu Met Glu Gln Cys Ser Asn Met
1105                1110                1115                1120
Gln Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys Leu
                1125                1130                1135
Leu Thr Asn Trp Met Ser Val Cys Leu Ser Gly Phe Leu Arg Glu Thr
            1140                1145                1150
Val Gly Glu Pro Phe Tyr Leu Leu Val Thr Thr Leu Asn Gln Lys Ile
        1155                1160                1165
Asn Lys Gly Pro Val Asp Val Ile Thr Cys Lys Ala Leu Tyr Thr Leu
    1170                1175                1180
Asn Glu Asp Trp Leu Leu Trp Gln Val Pro Glu Phe Ser Thr Val Ala
1185                1190                1195                1200
Leu Asn Val Val Phe Glu Lys Ile Pro Glu Asn Glu Ser Ala Asp Val
                1205                1210                1215
Cys Arg Asn Ile Ser Val Asn Val Leu Asp Cys Asp Thr Ile Gly Gln
            1220                1225                1230
Ala Lys Glu Lys Ile Phe Gln Ala Phe Leu Ser Lys Asn Gly Ser Pro
        1235                1240                1245
Tyr Gly Leu Gln Leu Asn Glu Ile Gly Leu Glu Leu Gln Met Gly Thr
    1250                1255                1260
Arg Gln Lys Glu Leu Leu Asp Ile Asp Ser Ser Ser Val Ile Leu Glu
1265                1270                1275                1280
Asp Gly Ile Thr Lys Leu Asn Thr Ile Gly His Tyr Glu Ile Ser Asn
                1285                1290                1295
Gly Ser Thr Ile Lys Val Phe Lys Lys Ile Ala Asn Phe Thr Ser Asp
            1300                1305                1310
Val Glu Tyr Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu
        1315                1320                1325
Ala Phe Gln Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe
    1330                1335                1340
Lys Val Lys Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Val Ala
1345                1350                1355                1360
Ile His Ser Val Leu Glu Lys Leu Phe Arg Ser Ile Trp Ser Leu Pro
                1365                1370                1375
Asn Ser Arg Ala Pro Phe Ala Ile Lys Tyr Phe Phe Asp Phe Leu Asp
            1380                1385                1390
Ala Gln Ala Glu Asn Lys Lys Ile Thr Asp Pro Asp Val Val His Ile
        1395                1400                1405
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys
    1410                1415                1420
Asn Pro Gln Phe Val Phe Asp Ile Lys Lys Thr Pro His Ile Asp Gly
1425                1430                1435                1440
Cys Leu Ser Val Ile Ala Gln Ala Phe Met Asp Ala Phe Ser Leu Thr
                1445                1450                1455
Glu Gln Gln Leu Gly Lys Glu Ala Pro Thr Asn Lys Leu Leu Tyr Ala
            1460                1465                1470
Lys Asp Ile Pro Thr Tyr Lys Glu Glu Val Lys Ser Tyr Tyr Lys Ala
        1475                1480                1485
Ile Arg Asp Leu Pro Pro Leu Ser Ser Ser Glu Met Glu Glu Phe Leu
    1490                1495                1500
Thr Gln Glu Ser Lys Lys His Glu Asn Glu Phe Asn Glu Glu Val Ala
1505                1510                1515                1520
Leu Thr Glu Ile Tyr Lys Tyr Ile Val Lys Tyr Phe Asp Glu Ile Leu
                1525                1530                1535
Asn Lys Leu Glu Arg Glu Arg Gly Leu Glu Glu Ala Gln Lys Gln Leu
            1540                1545                1550
Leu His Val Lys Val Leu Phe Asp Glu Lys Lys Lys Cys Lys Trp Met
        1555                1560                1565

<210> 1063
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 1063
Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala
 1               5                  10                  15
Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly
            20                  25                  30
Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala
        35                  40                  45
Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys
    50                  55                  60
Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr
65                  70                  75                  80
Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro
                85                  90                  95
Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr
            100                 105                 110
Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr
        115                 120                 125
Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg
    130                 135                 140
Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly
145                 150                 155                 160
Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr
                165                 170                 175
Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser
            180                 185                 190
Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys
        195                 200                 205
Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys
    210                 215                 220
Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp
225                 230                 235                 240
Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly
                245                 250                 255
Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu
            260                 265                 270
Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro
        275                 280                 285
Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp
    290                 295                 300
Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg
305                 310                 315                 320
Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile
                325                 330                 335
Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser
            340                 345                 350
His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser
        355                 360                 365
Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val
    370                 375                 380
Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu
385                 390                 395                 400
Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile
                405                 410                 415
Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp
            420                 425                 430
Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg
        435                 440                 445
Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys
    450                 455                 460
Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg
465                 470                 475                 480
Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp
                485                 490                 495
Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile
            500                 505                 510
Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser
        515                 520                 525
Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu
    530                 535                 540
Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile
545                 550                 555                 560
Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe
                565                 570                 575
Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys
            580                 585                 590
Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp
        595                 600                 605
Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro
    610                 615                 620
Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys
625                 630                 635                 640
Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn
                645                 650                 655
Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val
            660                 665                 670
Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr
        675                 680                 685
Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp
    690                 695                 700
Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys
705                 710                 715                 720
Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln
                725                 730                 735
Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala
            740                 745                 750
Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly
        755                 760                 765
Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn
    770                 775                 780
Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr
785                 790                 795                 800
Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser
                805                 810                 815
Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr
            820                 825                 830
Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly
        835                 840                 845
Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln
    850                 855                 860
Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr
865                 870                 875                 880
Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile
                885                 890                 895
Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile
            900                 905                 910
Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys
        915                 920                 925
Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr
    930                 935                 940
Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe
945                 950                 955                 960
Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys
                965                 970                 975
Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile
            980                 985                 990
Arg Asp Gly Phe Ala Glu Leu Gln Met Asp Lys Leu Asp Val Val Asp
        995                 1000                1005
Ser Phe Gly Thr Val Pro Phe Leu Asp Tyr Lys His Phe Ala Leu Arg
    1010                1015                1020
Thr Phe Phe Pro Glu Ser Gly Gly Phe Thr His Ile Phe Thr Glu Asp
1025                1030                1035                1040
Met His Asn Arg Asp Ala Asn Asp Lys Asn Glu Ser Leu Thr Ala Leu
                1045                1050                1055
Asp Ala Leu Ile Cys Asn Lys Ser Phe Leu Val Thr Val Ile His Thr
            1060                1065                1070
Leu Glu Lys Gln Lys Asn Phe Ser Val Lys Asp Arg Cys Leu Phe Ala
        1075                1080                1085
Ser Phe Leu Thr Ile Ala Leu Gln Thr Lys Leu Val Tyr Leu Thr Ser
    1090                1095                1100
Ile Leu Glu Val Leu Thr Arg Asp Leu Met Glu Gln Cys Ser Asn Met
1105                1110                1115                1120
Gln Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys Leu
                1125                1130                1135
Leu Thr Asn Trp Met Ser Val Cys Leu Ser Gly Phe Leu Arg Glu Thr
            1140                1145                1150
Val Gly Glu Pro Phe Tyr Leu Leu Val Thr Thr Leu Asn Gln Lys Ile
        1155                1160                1165
Asn Lys Gly Pro Val Asp Val Ile Thr Cys Lys Ala Leu Tyr Thr Leu
    1170                1175                1180
Asn Glu Asp Trp Leu Leu Trp Gln Val Pro Glu Phe Ser Thr Val Ala
1185                1190                1195                1200
Leu Asn Val Val Phe Glu Lys Ile Pro Glu Asn Glu Ser Ala Asp Val
                1205                1210                1215
Cys Arg Asn Ile Ser Val Asn Val Leu Asp Cys Asp Thr Ile Gly Gln
            1220                1225                1230
Ala Lys Glu Lys Ile Phe Gln Ala Phe Leu Ser Lys Asn Gly Ser Pro
        1235                1240                1245
Tyr Gly Leu Gln Leu Asn Glu Ile Gly Leu Glu Leu Gln Met Gly Thr
    1250                1255                1260
Arg Gln Lys Glu Leu Leu Asp Ile Asp Ser Ser Ser Val Ile Leu Glu
1265                1270                1275                1280
Asp Gly Ile Thr Lys Leu Asn Thr Ile Gly His Tyr Glu Ile Ser Asn
                1285                1290                1295
Gly Ser Thr Ile Lys Val Phe Lys Lys Ile Ala Asn Phe Thr Ser Asp
            1300                1305                1310
Val Glu Tyr Ser Asp Asp His Cys His Leu Ile Leu Pro Asp Ser Glu
        1315                1320                1325
Ala Phe Gln Asp Val Gln Gly Lys Arg His Arg Gly Lys His Lys Phe
    1330                1335                1340
Lys Val Lys Glu Met Tyr Leu Thr Lys Leu Leu Ser Thr Lys Val Ala
1345                1350                1355                1360
Ile His Ser Val Leu Glu Lys Leu Phe Arg Ser Ile Trp Ser Leu Pro
                1365                1370                1375
Asn Ser Arg Ala Pro Phe Ala Ile Lys Tyr Phe Phe Asp Phe Leu Asp
            1380                1385                1390
Ala Gln Ala Glu Asn Lys Lys Ile Thr Asp Pro Asp Val Val His Ile
        1395                1400                1405
Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys
    1410                1415                1420
Asn Pro Gln Phe Val Phe Asp Ile Lys Lys Thr Pro His Ile Asp Gly
1425                1430                1435                1440
Cys Leu Ser Val Ile Ala Gln Ala Phe Met Asp Ala Phe Ser Leu Thr
                1445                1450                1455
Glu Gln Gln Leu Gly Lys Glu Ala Pro Thr Asn Lys Leu Leu Tyr Ala
            1460                1465                1470
Lys Asp Ile Pro Thr Tyr Lys Glu Glu Val Lys Ser Tyr Tyr Lys Ala
        1475                1480                1485
Ile Arg Asp Leu Pro Pro Leu Ser Ser Ser Glu Met Glu Glu Phe Leu
    1490                1495                1500
Thr Gln Glu Ser Lys Lys His Glu Asn Glu Phe Asn Glu Glu Val Ala
1505                1510                1515                1520
Leu Thr Glu Ile Tyr Lys Tyr Ile Val Lys Tyr Phe Asp Glu Ile Leu
                1525                1530                1535
Asn Lys Leu Glu Arg Glu Arg Gly Leu Glu Glu Ala Gln Lys Gln Leu
            1540                1545                1550
Leu His Val Lys Val Leu Phe Asp Glu Lys Lys Lys Cys Lys Trp Met
        1555                1560                1565

<210> 1064
<211> 83
<212> PRT
<213> Homo sapiens

<400> 1064
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80
Cys Ala Gly


<210> 1065
<211> 477
<212> PRT
<213> Homo sapiens

<400> 1065
Val Pro Lys Glu His Leu Leu Val Ser Ile Pro Leu Leu Ile Asn His
 1               5                  10                  15
Leu Gln Ala Glu Ser Ile Val Val His Thr Tyr Ala Ala His Ala Leu
            20                  25                  30
Glu Arg Leu Phe Thr Met Arg Gly Pro Asn Asn Ala Thr Leu Phe Thr
        35                  40                  45
Ala Ala Glu Ile Ala Pro Phe Val Glu Ile Leu Leu Thr Asn Leu Phe
    50                  55                  60
Lys Ala Leu Thr Leu Pro Gly Ser Ser Glu Asn Glu Tyr Ile Met Lys
65                  70                  75                  80
Ala Ile Met Arg Ser Phe Ser Leu Leu Gln Glu Ala Ile Ile Pro Tyr
                85                  90                  95
Ile Pro Thr Leu Ile Thr Gln Leu Thr Gln Lys Leu Leu Ala Val Ser
            100                 105                 110
Lys Asn Pro Ser Lys Pro His Phe Asn His Tyr Met Phe Glu Ala Ile
        115                 120                 125
Cys Leu Ser Ile Arg Ile Thr Cys Lys Ala Asn Pro Ala Ala Val Val
    130                 135                 140
Asn Phe Glu Glu Ala Leu Phe Leu Val Phe Thr Glu Ile Leu Gln Asn
145                 150                 155                 160
Asp Val Gln Glu Phe Ile Pro Tyr Val Phe Gln Val Met Ser Leu Leu
                165                 170                 175
Leu Glu Thr His Lys Asn Asp Ile Pro Ser Ser Tyr Met Ala Leu Phe
            180                 185                 190
Pro His Leu Leu Gln Pro Val Leu Trp Glu Arg Thr Gly Asn Ile Pro
        195                 200                 205
Ala Leu Val Arg Leu Leu Gln Ala Phe Leu Glu Arg Gly Ser Asn Thr
    210                 215                 220
Ile Ala Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu Leu Gly Val Phe
225                 230                 235                 240
Gln Lys Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu
                245                 250                 255
Leu Asn Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr
            260                 265                 270
Arg Lys Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys
        275                 280                 285
Thr Thr Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys
    290                 295                 300
Ile Lys Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln
305                 310                 315                 320
Pro Lys Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile
                325                 330                 335
Gln Lys Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile
            340                 345                 350
Thr Lys Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr
        355                 360                 365
Lys Leu Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu
    370                 375                 380
Pro Glu Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu
385                 390                 395                 400
Asp Thr Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly
                405                 410                 415
Lys Lys Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile
            420                 425                 430
His Leu Ala Gln Ser Leu His Lys Leu Ser Thr Ala Cys Pro Gly Arg
        435                 440                 445
Val Pro Ser Met Val Ser Thr Ser Leu Asn Ala Glu Ala Leu Gln Tyr
    450                 455                 460
Leu Gln Gly Tyr Leu Gln Ala Ala Ser Val Thr Leu Leu
465                 470                 475

<210> 1066
<211> 211
<212> PRT
<213> Homo sapiens

<400> 1066
Gln Lys Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu
 1               5                  10                  15
Leu Asn Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr
            20                  25                  30
Arg Lys Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys
        35                  40                  45
Thr Thr Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys
    50                  55                  60
Ile Lys Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln
65                  70                  75                  80
Pro Lys Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile
                85                  90                  95
Gln Lys Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile
            100                 105                 110
Thr Lys Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr
        115                 120                 125
Lys Leu Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu
    130                 135                 140
Pro Glu Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu
145                 150                 155                 160
Asp Thr Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly
                165                 170                 175
Lys Lys Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile
            180                 185                 190
His Leu Ala Gln Ser Leu His Lys Leu Ser Thr Ala Cys Pro Gly Arg
        195                 200                 205
Thr Tyr Phe
    210

<210> 1067
<211> 971
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(971)
<223> Xaa = Any Amino Acid

<400> 1067
Met Glu Leu Ser Asp Ala Asn Leu Gln Thr Leu Thr Glu Tyr Leu Lys
 1               5                  10                  15
Lys Thr Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala Glu Lys Phe
            20                  25                  30
Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu Leu Leu Thr
        35                  40                  45
Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys Ala Ser Val
    50                  55                  60
Thr Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val Glu Asp Glu
65                  70                  75                  80
Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys Ala Asn Ile
                85                  90                  95
Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys Gln Leu Ser
            100                 105                 110
Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro
        115                 120                 125
Asp Leu Leu Thr Glu Met Val Asn Arg Phe Gln Ser Gly Asp Phe His
    130                 135                 140
Val Ile Asn Gly Val Leu Arg Thr Ala His Ser Leu Phe Lys Arg Tyr
145                 150                 155                 160
Arg His Glu Phe Lys Ser Asn Glu Leu Trp Thr Glu Ile Lys Leu Val
                165                 170                 175
Leu Asp Ala Phe Ala Leu Pro Leu Thr Asn Leu Phe Lys Ala Thr Ile
            180                 185                 190
Glu Leu Cys Ser Thr His Ala Asn Asp Ala Ser Ala Leu Arg Ile Leu
        195                 200                 205
Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu Phe Tyr Ser Leu Asn Phe
    210                 215                 220
Gln Asp Leu Pro Glu Phe Trp Glu Gly Asn Met Glu Thr Trp Met Asn
225                 230                 235                 240
Asn Phe His Thr Leu Leu Thr Leu Asp Asn Lys Leu Leu Gln Thr Asp
                245                 250                 255
Asp Glu Glu Glu Ala Gly Leu Leu Glu Leu Leu Lys Ser Gln Ile Cys
            260                 265                 270
Asp Asn Ala Ala Leu Tyr Ala Gln Lys Tyr Asp Glu Glu Phe Gln Arg
        275                 280                 285
Tyr Leu Pro Arg Phe Val Thr Ala Ile Trp Asn Leu Leu Val Thr Thr
    290                 295                 300
Gly Gln Glu Val Lys Tyr Asp Leu Leu Val Ser Asn Ala Ile Gln Phe
305                 310                 315                 320
Leu Ala Ser Val Cys Glu Arg Pro His Tyr Lys Asn Leu Phe Glu Asp
                325                 330                 335
Gln Asn Thr Leu Thr Ser Ile Cys Glu Lys Val Ile Val Pro Asn Met
            340                 345                 350
Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe Glu Asp Asn Ser Glu Glu
        355                 360                 365
Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp Ile Asp Thr Arg Arg Arg
    370                 375                 380
Ala Ala Cys Asp Leu Val Arg Gly Leu Cys Lys Phe Phe Glu Gly Pro
385                 390                 395                 400
Val Thr Gly Ile Phe Ser Gly Tyr Val Asn Ser Met Leu Gln Glu Tyr
                405                 410                 415
Ala Lys Asn Pro Ser Val Asn Trp Lys His Lys Asp Ala Ala Ile Tyr
            420                 425                 430
Leu Val Thr Ser Leu Ala Ser Lys Ala Gln Thr Gln Lys His Gly Ile
        435                 440                 445
Thr Gln Ala Asn Glu Leu Val Asn Leu Thr Glu Phe Phe Val Asn His
    450                 455                 460
Ile Leu Pro Asp Leu Lys Ser Ala Asn Val Asn Glu Phe Pro Val Leu
465                 470                 475                 480
Lys Ala Asp Gly Ile Lys Tyr Ile Met Ile Phe Arg Asn Gln Val Pro
                485                 490                 495
Lys Glu His Leu Leu Val Ser Ile Pro Leu Leu Ile Asn His Leu Gln
            500                 505                 510
Ala Gly Ser Ile Val Val His Thr Tyr Ala Ala His Ala Leu Glu Arg
        515                 520                 525
Leu Phe Thr Met Arg Gly Pro Asn Asn Ala Thr Leu Phe Thr Ala Ala
    530                 535                 540
Glu Ile Ala Pro Phe Val Glu Ile Leu Leu Thr Asn Leu Phe Lys Ala
545                 550                 555                 560
Leu Thr Leu Pro Gly Ser Ser Glu Asn Glu Tyr Ile Met Lys Ala Ile
                565                 570                 575
Met Arg Ser Phe Ser Leu Leu Gln Glu Ala Ile Ile Pro Tyr Ile Pro
            580                 585                 590
Thr Leu Ile Thr Gln Leu Thr Gln Lys Leu Leu Ala Val Ser Lys Asn
        595                 600                 605
Pro Ser Lys Pro His Phe Asn His Tyr Met Phe Glu Ala Ile Cys Leu
    610                 615                 620
Ser Ile Arg Ile Thr Cys Lys Ala Asn Pro Ala Ala Val Val Asn Phe
625                 630                 635                 640
Glu Glu Ala Leu Phe Leu Val Phe Thr Glu Ile Leu Gln Asn Asp Val
                645                 650                 655
Gln Glu Phe Ile Pro Tyr Val Phe Gln Val Met Ser Leu Leu Leu Glu
            660                 665                 670
Thr His Lys Asn Asp Ile Pro Ser Ser Tyr Met Ala Leu Phe Pro His
        675                 680                 685
Leu Leu Gln Pro Val Leu Trp Glu Arg Thr Gly Asn Ile Pro Ala Leu
    690                 695                 700
Val Arg Leu Leu Gln Ala Phe Leu Glu Arg Gly Ser Asn Thr Ile Ala
705                 710                 715                 720
Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu Leu Gly Val Phe Gln Lys
                725                 730                 735
Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu Leu Asn
            740                 745                 750
Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr Arg Lys
        755                 760                 765
Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys Thr Thr
    770                 775                 780
Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys Ile Lys
785                 790                 795                 800
Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln Pro Lys
                805                 810                 815
Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile Gln Lys
            820                 825                 830
Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile Thr Lys
        835                 840                 845
Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr Lys Leu
    850                 855                 860
Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu Pro Glu
865                 870                 875                 880
Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu Asp Thr
                885                 890                 895
Pro Xaa Tyr Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly Lys Lys
            900                 905                 910
Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile His Leu
        915                 920                 925
Ala Gln Ser Leu His Lys Leu Ser Thr Ala Cys Pro Gly Arg Val Pro
    930                 935                 940
Ser Met Val Ser Thr Ser Leu Asn Ala Glu Ala Leu Gln Tyr Leu Gln
945                 950                 955                 960
Gly Tyr Leu Gln Ala Ala Ser Val Thr Leu Leu
                965                 970

<210> 1068
<211> 211
<212> PRT
<213> Homo sapiens

<400> 1068
Gln Lys Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu
 1               5                  10                  15
Leu Asn Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr
            20                  25                  30
Arg Lys Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys
        35                  40                  45
Thr Thr Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys
    50                  55                  60
Ile Lys Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln
65                  70                  75                  80
Pro Lys Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile
                85                  90                  95
Gln Lys Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile
            100                 105                 110
Thr Lys Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr
        115                 120                 125
Lys Leu Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu
    130                 135                 140
Pro Glu Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu
145                 150                 155                 160
Asp Thr Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly
                165                 170                 175
Lys Lys Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile
            180                 185                 190
His Leu Ala Gln Ser Leu His Lys Leu Ser Thr Ala Cys Pro Gly Arg
        195                 200                 205
Thr Tyr Phe
    210

<210> 1069
<211> 971
<212> PRT
<213> Homo sapiens

<400> 1069
Met Glu Leu Ser Asp Ala Asn Leu Gln Thr Leu Thr Glu Tyr Leu Lys
 1               5                  10                  15
Lys Thr Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala Glu Lys Phe
            20                  25                  30
Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu Leu Leu Thr
        35                  40                  45
Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys Ala Ser Val
    50                  55                  60
Thr Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val Glu Asp Glu
65                  70                  75                  80
Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys Ala Asn Ile
                85                  90                  95
Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys Gln Leu Ser
            100                 105                 110
Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro
        115                 120                 125
Asp Leu Leu Thr Glu Met Val Asn Arg Phe Gln Ser Gly Asp Phe His
    130                 135                 140
Val Ile Asn Gly Val Leu Arg Thr Ala His Ser Leu Phe Lys Arg Tyr
145                 150                 155                 160
Arg His Glu Phe Lys Ser Asn Glu Leu Trp Thr Glu Ile Lys Leu Val
                165                 170                 175
Leu Asp Ala Phe Ala Leu Pro Leu Thr Asn Leu Phe Lys Ala Thr Ile
            180                 185                 190
Glu Leu Cys Ser Thr His Ala Asn Asp Ala Ser Ala Leu Arg Ile Leu
        195                 200                 205
Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu Phe Tyr Ser Leu Asn Phe
    210                 215                 220
Gln Asp Leu Pro Glu Phe Phe Glu Asp Asn Met Glu Thr Trp Met Asn
225                 230                 235                 240
Asn Phe His Thr Leu Leu Thr Leu Asp Asn Lys Leu Leu Gln Thr Asp
                245                 250                 255
Asp Glu Glu Glu Ala Gly Leu Leu Glu Leu Leu Lys Ser Gln Ile Cys
            260                 265                 270
Asp Asn Ala Ala Leu Tyr Ala Gln Lys Tyr Asp Glu Glu Phe Gln Arg
        275                 280                 285
Tyr Leu Pro Arg Phe Val Thr Ala Ile Trp Asn Leu Leu Val Thr Thr
    290                 295                 300
Gly Gln Glu Val Lys Tyr Asp Leu Leu Val Ser Asn Ala Ile Gln Phe
305                 310                 315                 320
Leu Ala Ser Val Cys Glu Arg Pro His Tyr Lys Asn Leu Phe Glu Asp
                325                 330                 335
Gln Asn Thr Leu Thr Ser Ile Cys Glu Lys Val Ile Val Pro Asn Met
            340                 345                 350
Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe Glu Asp Asn Ser Glu Glu
        355                 360                 365
Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp Ile Asp Thr Arg Arg Arg
    370                 375                 380
Ala Ala Cys Asp Leu Val Arg Gly Leu Cys Lys Phe Phe Glu Gly Pro
385                 390                 395                 400
Val Thr Gly Ile Phe Ser Gly Tyr Val Asn Ser Met Leu Gln Glu Tyr
                405                 410                 415
Ala Lys Asn Pro Ser Val Asn Trp Lys His Lys Asp Ala Ala Ile Tyr
            420                 425                 430
Leu Val Thr Ser Leu Ala Ser Lys Ala Gln Thr Gln Lys His Gly Ile
        435                 440                 445
Thr Gln Ala Asn Glu Leu Val Asn Leu Thr Glu Phe Phe Val Asn His
    450                 455                 460
Ile Leu Pro Asp Leu Lys Ser Ala Asn Val Asn Glu Phe Pro Val Leu
465                 470                 475                 480
Lys Ala Asp Gly Ile Lys Tyr Ile Met Ile Phe Arg Asn Gln Val Pro
                485                 490                 495
Lys Glu His Leu Leu Val Ser Ile Pro Leu Leu Ile Asn His Leu Gln
            500                 505                 510
Ala Glu Ser Ile Val Val His Thr Tyr Ala Ala His Ala Leu Glu Arg
        515                 520                 525
Leu Phe Thr Met Arg Gly Pro Asn Asn Ala Thr Leu Phe Thr Ala Ala
    530                 535                 540
Glu Ile Ala Pro Phe Val Glu Ile Leu Leu Thr Asn Leu Phe Lys Ala
545                 550                 555                 560
Leu Thr Leu Pro Gly Ser Ser Glu Asn Glu Tyr Ile Met Lys Ala Ile
                565                 570                 575
Met Arg Ser Phe Ser Leu Leu Gln Glu Ala Ile Ile Pro Tyr Ile Pro
            580                 585                 590
Thr Leu Ile Thr Gln Leu Thr Gln Lys Leu Leu Ala Val Ser Lys Asn
        595                 600                 605
Pro Ser Lys Pro His Phe Asn His Tyr Met Phe Glu Ala Ile Cys Leu
    610                 615                 620
Ser Ile Arg Ile Thr Cys Lys Ala Asn Pro Ala Ala Val Val Asn Phe
625                 630                 635                 640
Glu Glu Ala Leu Phe Leu Val Phe Thr Glu Ile Leu Gln Asn Asp Val
                645                 650                 655
Gln Glu Phe Ile Pro Tyr Val Phe Gln Val Met Ser Leu Leu Leu Glu
            660                 665                 670
Thr His Lys Asn Asp Ile Pro Ser Ser Tyr Met Ala Leu Phe Pro His
        675                 680                 685
Leu Leu Gln Pro Val Leu Trp Glu Arg Thr Gly Asn Ile Pro Ala Leu
    690                 695                 700
Val Arg Leu Leu Gln Ala Phe Leu Glu Arg Gly Ser Asn Thr Ile Ala
705                 710                 715                 720
Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu Leu Gly Val Phe Gln Lys
                725                 730                 735
Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu Leu Asn
            740                 745                 750
Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr Arg Lys
        755                 760                 765
Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys Thr Thr
    770                 775                 780
Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys Ile Lys
785                 790                 795                 800
Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln Pro Lys
                805                 810                 815
Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile Gln Lys
            820                 825                 830
Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile Thr Lys
        835                 840                 845
Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr Lys Leu
    850                 855                 860
Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu Pro Glu
865                 870                 875                 880
Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu Asp Thr
                885                 890                 895
Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly Lys Lys
            900                 905                 910
Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile His Leu
        915                 920                 925
Ala Gln Ser Leu His Lys Leu Ser Thr Ala Cys Pro Gly Arg Val Pro
    930                 935                 940
Ser Met Val Ser Thr Ser Leu Asn Ala Glu Ala Leu Gln Tyr Leu Gln
945                 950                 955                 960
Gly Tyr Leu Gln Ala Ala Ser Val Thr Leu Leu
                965                 970

<210> 1070
<211> 971
<212> PRT
<213> Homo sapiens

<400> 1070
Met Glu Leu Ser Asp Ala Asn Leu Gln Thr Leu Thr Glu Tyr Leu Lys
 1               5                  10                  15
Lys Thr Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala Glu Lys Phe
            20                  25                  30
Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu Leu Leu Thr
        35                  40                  45
Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys Ala Ser Val
    50                  55                  60
Thr Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val Glu Asp Glu
65                  70                  75                  80
Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys Ala Asn Ile
                85                  90                  95
Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys Gln Leu Ser
            100                 105                 110
Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro
        115                 120                 125
Asp Leu Leu Thr Glu Met Val Asn Arg Phe Gln Ser Gly Asp Phe His
    130                 135                 140
Val Ile Asn Gly Val Leu Arg Thr Ala His Ser Leu Phe Lys Arg Tyr
145                 150                 155                 160
Arg His Glu Phe Lys Ser Asn Glu Leu Trp Thr Glu Ile Lys Leu Val
                165                 170                 175
Leu Asp Ala Phe Ala Leu Pro Leu Thr Asn Leu Phe Lys Ala Thr Ile
            180                 185                 190
Glu Leu Cys Ser Thr His Ala Asn Asp Ala Ser Ala Leu Arg Ile Leu
        195                 200                 205
Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu Phe Tyr Ser Leu Asn Phe
    210                 215                 220
Gln Asp Leu Pro Glu Phe Trp Glu Gly Asn Met Glu Thr Trp Met Asn
225                 230                 235                 240
Asn Phe His Thr Leu Leu Thr Leu Asp Asn Lys Leu Leu Gln Thr Asp
                245                 250                 255
Asp Glu Glu Glu Ala Gly Leu Leu Glu Leu Leu Lys Ser Gln Ile Cys
            260                 265                 270
Asp Asn Ala Ala Leu Tyr Ala Gln Lys Tyr Asp Glu Glu Phe Gln Arg
        275                 280                 285
Tyr Leu Pro Arg Phe Val Thr Ala Ile Trp Asn Leu Leu Val Thr Thr
    290                 295                 300
Gly Gln Glu Val Lys Tyr Asp Leu Leu Val Ser Asn Ala Ile Gln Phe
305                 310                 315                 320
Leu Ala Ser Val Cys Glu Arg Pro His Tyr Lys Asn Leu Phe Glu Asp
                325                 330                 335
Gln Asn Thr Leu Thr Ser Ile Cys Glu Lys Val Ile Val Pro Asn Met
            340                 345                 350
Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe Glu Asp Asn Ser Glu Glu
        355                 360                 365
Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp Ile Asp Thr Arg Arg Arg
    370                 375                 380
Ala Ala Cys Asp Leu Val Arg Gly Leu Cys Lys Phe Phe Glu Gly Pro
385                 390                 395                 400
Val Thr Gly Ile Phe Ser Gly Tyr Val Asn Ser Met Leu Gln Glu Tyr
                405                 410                 415
Ala Lys Asn Pro Ser Val Asn Trp Lys His Lys Asp Ala Ala Ile Tyr
            420                 425                 430
Leu Val Thr Ser Leu Ala Ser Lys Ala Gln Thr Gln Lys His Gly Ile
        435                 440                 445
Thr Gln Ala Asn Glu Leu Val Asn Leu Thr Glu Phe Phe Val Asn His
    450                 455                 460
Ile Leu Pro Asp Leu Lys Ser Ala Asn Val Asn Glu Phe Pro Val Leu
465                 470                 475                 480
Lys Ala Asp Gly Ile Lys Tyr Ile Met Ile Phe Arg Asn Gln Val Pro
                485                 490                 495
Lys Glu His Leu Leu Val Ser Ile Pro Leu Leu Ile Asn His Leu Gln
            500                 505                 510
Ala Gly Ser Ile Val Val His Thr Tyr Ala Ala His Ala Leu Glu Arg
        515                 520                 525
Leu Phe Thr Met Arg Gly Pro Asn Asn Ala Thr Leu Phe Thr Ala Ala
    530                 535                 540
Glu Ile Ala Pro Phe Val Glu Ile Leu Leu Thr Asn Leu Phe Lys Ala
545                 550                 555                 560
Leu Thr Leu Pro Gly Ser Ser Glu Asn Glu Tyr Ile Met Lys Ala Ile
                565                 570                 575
Met Arg Ser Phe Ser Leu Leu Gln Glu Ala Ile Ile Pro Tyr Ile Pro
            580                 585                 590
Thr Leu Ile Thr Gln Leu Thr Gln Lys Leu Leu Ala Val Ser Lys Asn
        595                 600                 605
Pro Ser Lys Pro His Phe Asn His Tyr Met Phe Glu Ala Ile Cys Leu
    610                 615                 620
Ser Ile Arg Ile Thr Cys Lys Ala Asn Pro Ala Ala Val Val Asn Phe
625                 630                 635                 640
Glu Glu Ala Leu Phe Leu Val Phe Thr Glu Ile Leu Gln Asn Asp Val
                645                 650                 655
Gln Glu Phe Ile Pro Tyr Val Phe Gln Val Met Ser Leu Leu Leu Glu
            660                 665                 670
Thr His Lys Asn Asp Ile Pro Ser Ser Tyr Met Ala Leu Phe Pro His
        675                 680                 685
Leu Leu Gln Pro Val Leu Trp Glu Arg Thr Gly Asn Ile Pro Ala Leu
    690                 695                 700
Val Arg Leu Leu Gln Ala Phe Leu Glu Arg Gly Ser Asn Thr Ile Ala
705                 710                 715                 720
Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu Leu Gly Val Phe Gln Lys
                725                 730                 735
Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu Leu Asn
            740                 745                 750
Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr Arg Lys
        755                 760                 765
Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys Thr Thr
    770                 775                 780
Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys Ile Lys
785                 790                 795                 800
Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln Pro Lys
                805                 810                 815
Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile Gln Lys
            820                 825                 830
Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile Thr Asn
        835                 840                 845
Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr Lys Leu
    850                 855                 860
Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu Pro Glu
865                 870                 875                 880
Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu Asp Thr
                885                 890                 895
Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly Lys Lys
            900                 905                 910
Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile His Leu
        915                 920                 925
Ala Gln Ser Leu His Met Leu Ser Thr Ala Cys Pro Gly Arg Val Pro
    930                 935                 940
Ser Met Val Ser Thr Ser Leu Asn Ala Glu Ala Leu Gln Tyr Leu Gln
945                 950                 955                 960
Gly Tyr Leu Gln Ala Ala Ser Val Thr Leu Leu
                965                 970

<210> 1071
<211> 640
<212> PRT
<213> Homo sapiens

<400> 1071
Trp Val Arg Pro Thr Arg Pro Thr Leu Thr Ser Ile Cys Glu Lys Val
 1               5                  10                  15
Ile Val Pro Asn Met Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe Glu
            20                  25                  30
Asp Asn Ser Glu Glu Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp Ile
        35                  40                  45
Asp Thr Arg Arg Arg Ala Ala Cys Asp Leu Val Arg Gly Leu Cys Lys
    50                  55                  60
Phe Phe Glu Gly Pro Val Thr Gly Ile Phe Ser Gly Tyr Val Asn Ser
65                  70                  75                  80
Met Leu Gln Glu Tyr Ala Lys Asn Pro Ser Val Asn Trp Lys His Lys
                85                  90                  95
Asp Ala Ala Ile Tyr Leu Val Thr Ser Leu Ala Ser Lys Ala Gln Thr
            100                 105                 110
Gln Lys His Gly Ile Thr Gln Ala Asn Glu Leu Val Asn Leu Thr Glu
        115                 120                 125
Phe Phe Val Asn His Ile Leu Pro Asp Leu Lys Ser Ala Asn Val Asn
    130                 135                 140
Glu Phe Pro Val Leu Lys Ala Asp Gly Ile Lys Tyr Ile Met Ile Phe
145                 150                 155                 160
Arg Asn Gln Val Pro Lys Glu His Leu Leu Val Ser Ile Pro Leu Leu
                165                 170                 175
Ile Asn His Leu Gln Ala Glu Ser Ile Val Val His Thr Tyr Ala Ala
            180                 185                 190
His Ala Leu Glu Arg Leu Phe Thr Met Arg Gly Pro Asn Asn Ala Thr
        195                 200                 205
Leu Phe Thr Ala Ala Glu Ile Ala Pro Phe Val Glu Ile Leu Leu Thr
    210                 215                 220
Asn Leu Phe Lys Ala Leu Thr Leu Pro Gly Ser Ser Glu Asn Glu Tyr
225                 230                 235                 240
Ile Met Lys Ala Ile Met Arg Ser Phe Ser Leu Leu Gln Glu Ala Ile
                245                 250                 255
Ile Pro Tyr Ile Pro Thr Leu Ile Thr Gln Leu Thr Gln Lys Leu Leu
            260                 265                 270
Ala Val Ser Lys Asn Pro Ser Lys Pro His Phe Asn His Tyr Met Phe
        275                 280                 285
Glu Ala Ile Cys Leu Ser Ile Arg Ile Thr Cys Lys Ala Asn Pro Ala
    290                 295                 300
Ala Val Val Asn Phe Glu Glu Ala Leu Phe Leu Val Phe Thr Glu Ile
305                 310                 315                 320
Leu Gln Asn Asp Val Gln Glu Phe Ile Pro Tyr Val Phe Gln Val Met
                325                 330                 335
Ser Leu Leu Leu Glu Thr His Lys Asn Asp Ile Pro Ser Ser Tyr Met
            340                 345                 350
Ala Leu Phe Pro His Leu Leu Gln Pro Val Leu Trp Glu Arg Thr Gly
        355                 360                 365
Asn Ile Pro Ala Leu Val Arg Leu Leu Gln Ala Phe Leu Glu Arg Gly
    370                 375                 380
Ser Asn Thr Ile Ala Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu Leu
385                 390                 395                 400
Gly Val Phe Gln Lys Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly
                405                 410                 415
Phe Tyr Leu Leu Asn Ser Ile Ile Glu His Met Pro Pro Glu Ser Val
            420                 425                 430
Asp Gln Tyr Arg Lys Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln
        435                 440                 445
Asn Ser Lys Thr Thr Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn
    450                 455                 460
Leu Tyr Cys Ile Lys Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp
465                 470                 475                 480
Gly Ile Gln Pro Lys Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile
                485                 490                 495
Pro Glu Ile Gln Lys Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala
            500                 505                 510
Val Gly Ile Thr Lys Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr
        515                 520                 525
Glu Tyr Thr Lys Leu Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu
    530                 535                 540
Phe Glu Leu Pro Glu Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile
545                 550                 555                 560
Asp Ile Glu Asp Thr Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu Ala
                565                 570                 575
Phe Ala Gly Lys Lys Glu His Asp Pro Val Gly Gln Met Val Asn Asn
            580                 585                 590
Pro Lys Ile His Leu Ala Gln Ser Leu His Lys Leu Ser Thr Ala Cys
        595                 600                 605
Pro Gly Arg Val Pro Ser Met Val Ser Thr Ser Leu Asn Ala Glu Ala
    610                 615                 620
Leu Gln Tyr Leu Gln Gly Tyr Leu Gln Ala Ala Ser Val Thr Leu Leu
625                 630                 635                 640

<210> 1072
<211> 408
<212> PRT
<213> Homo sapiens

<400> 1072
Lys Ile Met Ala His Tyr Gly Ser Ile Gln Tyr Cys Phe His Thr Cys
 1               5                  10                  15
Thr Leu Glu Thr Lys Phe Pro Ile Ile Pro Tyr Ile Pro Thr Leu Ile
            20                  25                  30
Thr Gln Leu Thr Gln Lys Leu Leu Ala Val Ser Lys Asn Pro Ser Lys
        35                  40                  45
Pro His Phe Asn His Tyr Met Phe Glu Ala Ile Cys Leu Ser Ile Arg
    50                  55                  60
Ile Thr Cys Lys Ala Asn Pro Ala Ala Val Val Asn Phe Glu Glu Ala
65                  70                  75                  80
Leu Phe Leu Val Phe Thr Glu Ile Leu Gln Asn Asp Val Gln Glu Phe
                85                  90                  95
Ile Pro Tyr Val Phe Gln Val Met Ser Leu Leu Leu Glu Thr His Lys
            100                 105                 110
Asn Asp Ile Pro Ser Ser Tyr Met Ala Leu Phe Pro His Leu Leu Gln
        115                 120                 125
Pro Val Leu Trp Glu Arg Thr Gly Asn Ile Pro Ala Leu Val Arg Leu
    130                 135                 140
Leu Gln Ala Phe Leu Glu Arg Gly Ser Asn Thr Ile Ala Ser Ala Ala
145                 150                 155                 160
Ala Asp Lys Ile Pro Gly Leu Leu Gly Val Phe Gln Lys Leu Ile Ala
                165                 170                 175
Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu Leu Asn Ser Ile Ile
            180                 185                 190
Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr Arg Lys Gln Ile Phe
        195                 200                 205
Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys Thr Thr Lys Phe Ile
    210                 215                 220
Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys Ile Lys Tyr Gly Ala
225                 230                 235                 240
Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln Pro Lys Met Phe Gly
                245                 250                 255
Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile Gln Lys Val Ser Gly
            260                 265                 270
Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile Thr Lys Leu Leu Thr
        275                 280                 285
Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr Lys Leu Trp Thr Pro
    290                 295                 300
Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu Pro Glu Asp Asp Thr
305                 310                 315                 320
Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu Asp Thr Pro Gly Tyr
                325                 330                 335
Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly Lys Lys Glu His Asp
            340                 345                 350
Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile His Leu Ala Gln Ser
        355                 360                 365
Leu His Lys Leu Ser Thr Ala Cys Pro Gly Arg Val Pro Ser Met Val
    370                 375                 380
Ser Thr Ser Leu Asn Ala Glu Ala Leu Gln Tyr Leu Gln Gly Tyr Leu
385                 390                 395                 400
Gln Ala Ala Ser Val Thr Leu Leu
                405

<210> 1073
<211> 1160
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(1160)
<223> Xaa = Any Amino Acid

<400> 1073
Met His Tyr Val Leu Asn Ser Ser Ser Met Glu Thr Phe Val Gly Glu
 1               5                  10                  15
Gln Asn Tyr Glu Gly Ser Ser Arg Leu Cys Val Cys Lys Arg Thr Arg
            20                  25                  30
Glu Ala Asp Asp Pro Ser Ala Arg Asp Ser Val Cys Glu Gly Val Arg
        35                  40                  45
Ala Arg Phe Asn Ile Cys Gly Ile Asn Gln Ile Val Leu Lys Cys Pro
    50                  55                  60
Ile Trp Gly Cys Glu Asn Pro Ala Gln Met Gly Cys Pro Pro Val Gly
65                  70                  75                  80
Lys Ala Asp Arg Cys Gly Leu Leu Ala Asn Ser Ala Thr Cys Glu Lys
                85                  90                  95
Gly Met Phe Cys His Ala Asp Leu Val Gly Ile Thr Pro Thr Val Phe
            100                 105                 110
Pro Ser His Pro Arg Cys Lys Thr Thr Ala Ser Ala Lys Leu Ala Cys
        115                 120                 125
Gln Gln Asp Val Asp Leu Asp Arg Gln Ser Leu Ser Ser Ile Asp Lys
    130                 135                 140
Asn Pro Ser Glu Arg Gly Gln Ser Gln Leu Ser Asn Pro Thr Asp Asp
145                 150                 155                 160
Ser Trp Lys Gly Arg Pro Tyr Ala Asn Gln Lys Leu Phe Ala Ser Leu
                165                 170                 175
Leu Ile Lys Cys Val Val Gln Leu Glu Leu Ile Gln Thr Ile Asp Asn
            180                 185                 190
Ile Val Phe Tyr Pro Ala Thr Ser Lys Lys Glu Asp Ala Glu His Met
        195                 200                 205
Val Ala Ala Gln Gln Asp Thr Leu Asp Ala Asp Ile His Ile Glu Thr
    210                 215                 220
Glu Asp Gln Gly Met Tyr Lys Tyr Met Ser Ser Gln His Leu Phe Lys
225                 230                 235                 240
Leu Leu Asp Cys Leu Gln Glu Ser His Ser Phe Ser Lys Ala Phe Asn
                245                 250                 255
Ser Asn Tyr Glu Gln Arg Thr Val Leu Trp Arg Ala Gly Phe Lys Gly
            260                 265                 270
Lys Ser Lys Pro Asn Leu Leu Lys Gln Glu Thr Ser Ser Leu Ala Cys
        275                 280                 285
Cys Leu Arg Ile Leu Phe Arg Met Tyr Val Asp Glu Asn Arg Arg Asp
    290                 295                 300
Ser Trp Glu Glu Ile Gln Gln Arg Leu Leu Thr Val Cys Ser Glu Thr
305                 310                 315                 320
Lys Thr Leu Lys Ile Asn Asp Glu Lys Phe Lys Ala His Ala Ser Met
                325                 330                 335
Tyr Tyr Pro Tyr Leu Cys Glu Ile Met Gln Phe Asp Leu Ile Pro Glu
            340                 345                 350
Leu Arg Ala Val Leu Arg Lys Phe Phe Leu Arg Ile Gly Val Val Tyr
        355                 360                 365
Lys Ile Trp Ile Pro Glu Glu Pro Ser Gln Ala Arg Cys Arg Ala Ile
    370                 375                 380
Leu Pro Gly Phe Glu Cys Glu Ala Glu Arg Arg Gln Glu Arg Val Val
385                 390                 395                 400
Pro Ala Thr Val Arg Gly Trp Gly Ser Leu Leu Arg Phe Cys Ile Pro
                405                 410                 415
Thr Ser Ser Tyr Asn Lys Cys Leu Leu Asn Met Tyr Cys Val Pro Asp
            420                 425                 430
Pro Ile Ala Met Glu Leu Ser Asp Ala Asn Leu Gln Thr Leu Thr Glu
        435                 440                 445
Tyr Leu Lys Lys Thr Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala
    450                 455                 460
Glu Lys Phe Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu
465                 470                 475                 480
Leu Leu Thr Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys
                485                 490                 495
Ala Ser Val Thr Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val
            500                 505                 510
Glu Asp Glu Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys
        515                 520                 525
Ala Asn Ile Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys
    530                 535                 540
Gln Leu Ser Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln
545                 550                 555                 560
Lys Trp Pro Asp Leu Leu Thr Glu Met Val Asn Arg Phe Gln Ser Gly
                565                 570                 575
Asp Phe His Val Ile Asn Gly Val Leu Arg Thr Ala His Ser Leu Phe
            580                 585                 590
Lys Arg Tyr Arg His Glu Phe Lys Ser Asn Glu Leu Trp Thr Glu Ile
        595                 600                 605
Lys Leu Val Leu Asp Ala Phe Ala Leu Pro Leu Thr Asn Leu Phe Lys
    610                 615                 620
Ile Cys Asp Asn Ala Ala Leu Tyr Ala Gln Lys Tyr Asp Glu Glu Phe
625                 630                 635                 640
Gln Arg Tyr Leu Pro Arg Phe Val Thr Ala Ile Trp Asn Leu Leu Val
                645                 650                 655
Thr Thr Gly Gln Glu Val Lys Tyr Asp Leu Leu Val Ser Asn Ala Ile
            660                 665                 670
Gln Phe Leu Ala Ser Val Cys Glu Arg Pro His Tyr Lys Asn Leu Phe
        675                 680                 685
Glu Asp Gln Asn Thr Leu Thr Ser Ile Cys Glu Lys Val Ile Val Pro
    690                 695                 700
Asn Met Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe Glu Asp Asn Ser
705                 710                 715                 720
Glu Glu Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp Ile Asp Thr Arg
                725                 730                 735
Arg Arg Ala Ala Cys Asp Leu Val Arg Gly Leu Cys Lys Phe Phe Glu
            740                 745                 750
Gly Pro Val Thr Gly Ile Phe Ser Gly Tyr Val Asn Ser Met Leu Gln
        755                 760                 765
Glu Tyr Ala Lys Asn Pro Ser Val Asn Trp Lys His Lys Asp Ala Ala
    770                 775                 780
Ile Tyr Leu Val Thr Ser Leu Ala Ser Lys Ala Gln Thr Gln Lys His
785                 790                 795                 800
Gly Ile Thr Gln Ala Asn Glu Leu Val Asn Leu Thr Glu Phe Phe Val
                805                 810                 815
Asn His Ile Leu Pro Asp Leu Lys Ser Ala Asn Ala Ile Met Arg Ser
            820                 825                 830
Phe Ser Leu Leu Gln Glu Ala Ile Ile Pro Tyr Ile Pro Thr Leu Ile
        835                 840                 845
Thr Gln Leu Thr Gln Lys Leu Leu Ala Val Ser Lys Asn Pro Ser Lys
    850                 855                 860
Pro His Phe Asn His Tyr Met Phe Glu Ala Ile Cys Leu Ser Ile Arg
865                 870                 875                 880
Ile Thr Cys Lys Ala Asn Pro Ala Ala Val Val Asn Phe Glu Glu Ala
                885                 890                 895
Leu Phe Leu Val Phe Thr Glu Ile Leu Gln Asn Asp Val Pro Ser Glu
            900                 905                 910
Ser Val Asp Gln Tyr Arg Lys Gln Ile Phe Ile Leu Leu Phe Gln Arg
        915                 920                 925
Leu Gln Asn Ser Lys Thr Thr Lys Phe Ile Lys Ser Lys Xaa Asn His
    930                 935                 940
Leu Asp Val Leu Gln Lys Xaa Xaa Lys Lys Met Phe Gly Met Val Leu
945                 950                 955                 960
Glu Lys Ile Ile Ile Pro Glu Ile Gln Lys Val Ser Gly Asn Val Glu
                965                 970                 975
Lys Lys Ile Cys Ala Val Gly Ile Thr Lys Leu Leu Thr Glu Cys Pro
            980                 985                 990
Pro Met Met Asp Thr Glu Tyr Thr Lys Leu Trp Thr Pro Leu Leu Gln
        995                 1000                1005
Ser Leu Ile Gly Leu Phe Glu Leu Pro Glu Asp Asp Thr Ile Pro Asp
    1010                1015                1020
Glu Glu His Phe Ile Asp Ile Glu Asp Thr Pro Gly Tyr Gln Thr Ala
1025                1030                1035                1040
Phe Ser Gln Leu Ala Phe Ala Gly Lys Lys Glu His Asp Pro Val Gly
                1045                1050                1055
Gln Met Val Asn Asn Pro Lys Ile His Leu Ala Gln Ser Leu His Lys
            1060                1065                1070
Leu Ser Thr Ala Cys Pro Gly Arg Ser Cys Gly Ser Ser Pro Val Glu
        1075                1080                1085
Asp Gly Val Cys Ile Gly Ala Pro Arg Ser Pro Thr Ala Ser Val Cys
    1090                1095                1100
Phe Pro Ser Leu Val Gly Ser Ile Asn Gly Pro Ala Pro Ala Pro Pro
1105                1110                1115                1120
Pro Pro Thr Val Arg Thr Thr Ser Ser Gly Trp His Cys Gly Gly Ala
                1125                1130                1135
Cys Ala Arg Lys Ala Arg Arg Gly Pro Ser Gly Arg Ser Ala Leu Ser
            1140                1145                1150
Arg Leu Asp Arg Ser Gly Pro Ser
        1155                1160

<210> 1074
<211> 993
<212> PRT
<213> Homo sapiens

<400> 1074
Cys Gln Leu Arg Ser Ala Ala Gly Val Pro Ser Ser Val Ser Val Ser
 1               5                  10                  15
Pro Arg Asp Pro Ile Ala Met Glu Leu Ser Asp Ala Asn Leu Gln Thr
            20                  25                  30
Leu Thr Glu Tyr Leu Lys Lys Thr Leu Asp Pro Asp Pro Ala Ile Arg
        35                  40                  45
Arg Pro Ala Glu Lys Phe Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr
    50                  55                  60
Pro Leu Leu Leu Leu Thr Leu Leu Glu Lys Ser Gln Asp Asn Val Ile
65                  70                  75                  80
Lys Val Cys Ala Ser Val Thr Phe Lys Asn Tyr Ile Lys Arg Asn Trp
                85                  90                  95
Arg Ile Val Glu Asp Glu Pro Asn Lys Ile Cys Glu Ala Asp Arg Val
            100                 105                 110
Ala Ile Lys Ala Asn Ile Val His Leu Met Leu Ser Ser Pro Glu Gln
        115                 120                 125
Ile Gln Lys Gln Leu Ser Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp
    130                 135                 140
Phe Pro Gln Lys Trp Pro Asp Leu Leu Thr Glu Met Val Asn Arg Phe
145                 150                 155                 160
Gln Ser Gly Asp Phe His Val Ile Asn Gly Val Leu Arg Thr Ala His
                165                 170                 175
Ser Leu Phe Lys Arg Tyr Arg His Glu Phe Lys Ser Asn Glu Leu Trp
            180                 185                 190
Thr Glu Ile Lys Leu Val Leu Asp Ala Phe Ala Leu Pro Leu Thr Tyr
        195                 200                 205
Leu Phe Lys Ala Thr Ile Glu Leu Cys Ser Thr His Ala Asn Asp Ala
    210                 215                 220
Ser Ala Leu Arg Ile Leu Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu
225                 230                 235                 240
Phe Tyr Ser Leu Asn Phe Gln Asp Leu Pro Glu Phe Phe Glu Asp Asn
                245                 250                 255
Met Glu Thr Trp Met Asn Asn Phe His Thr Leu Leu Thr Leu Asp Asn
            260                 265                 270
Lys Leu Leu Gln Thr Asp Asp Glu Glu Glu Ala Gly Leu Leu Glu Leu
        275                 280                 285
Leu Lys Ser Gln Ile Cys Asp Asn Ala Ala Leu Tyr Ala Gln Lys Tyr
    290                 295                 300
Asp Glu Glu Phe Gln Arg Tyr Leu Pro Arg Phe Val Thr Ala Ile Trp
305                 310                 315                 320
Asn Leu Leu Val Thr Thr Gly Gln Glu Val Lys Tyr Asp Leu Leu Val
                325                 330                 335
Ser Asn Ala Ile Gln Phe Leu Ala Ser Val Cys Glu Arg Pro His Tyr
            340                 345                 350
Lys Asn Leu Phe Glu Asp Gln Asn Thr Leu Thr Ser Ile Cys Glu Lys
        355                 360                 365
Val Ile Val Pro Asn Met Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe
    370                 375                 380
Glu Asp Asn Ser Glu Glu Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp
385                 390                 395                 400
Ile Asp Thr Arg Arg Arg Ala Ala Cys Asp Leu Val Arg Gly Leu Cys
                405                 410                 415
Lys Phe Phe Glu Gly Pro Val Thr Gly Ile Phe Ser Gly Tyr Val Asn
            420                 425                 430
Ser Met Leu Gln Glu Tyr Ala Lys Asn Pro Ser Val Asn Trp Lys His
        435                 440                 445
Lys Asp Ala Ala Ile Tyr Leu Val Thr Ser Leu Ala Ser Lys Ala Gln
    450                 455                 460
Thr Gln Lys His Gly Ile Thr Gln Ala Asn Glu Leu Val Asn Leu Thr
465                 470                 475                 480
Glu Phe Phe Val Asn His Ile Leu Pro Asp Leu Lys Ser Ala Asn Val
                485                 490                 495
Asn Glu Phe Pro Val Leu Lys Ala Asp Gly Ile Lys Tyr Ile Met Ile
            500                 505                 510
Phe Arg Asn Gln Val Pro Lys Glu His Leu Leu Val Ser Ile Pro Leu
        515                 520                 525
Leu Ile Asn His Leu Gln Ala Gly Ser Ile Val Val His Thr Tyr Ala
    530                 535                 540
Ala His Ala Leu Glu Arg Leu Phe Thr Met Arg Gly Pro Asn Asn Ala
545                 550                 555                 560
Thr Leu Phe Thr Ala Ala Glu Ile Ala Pro Phe Val Glu Ile Leu Leu
                565                 570                 575
Thr Asn Leu Phe Lys Ala Leu Thr Leu Pro Gly Ser Ser Glu Asn Glu
            580                 585                 590
Tyr Ile Met Lys Ala Ile Met Arg Ser Phe Ser Leu Leu Gln Glu Ala
        595                 600                 605
Ile Ile Pro Tyr Ile Pro Thr Leu Ile Thr Gln Leu Thr Gln Lys Leu
    610                 615                 620
Leu Ala Val Ser Lys Asn Pro Ser Lys Pro His Phe Asn His Tyr Met
625                 630                 635                 640
Phe Glu Ala Ile Cys Leu Ser Ile Arg Ile Thr Cys Lys Ala Asn Pro
                645                 650                 655
Ala Ala Val Val Asn Phe Glu Glu Ala Leu Phe Leu Val Phe Thr Glu
            660                 665                 670
Ile Leu Gln Asn Asp Val Gln Glu Phe Ile Pro Tyr Val Phe Gln Val
        675                 680                 685
Met Ser Leu Leu Leu Glu Thr His Lys Asn Asp Ile Pro Ser Ser Tyr
    690                 695                 700
Met Ala Leu Phe Pro His Leu Leu Gln Pro Val Leu Trp Glu Arg Thr
705                 710                 715                 720
Gly Asn Ile Pro Ala Leu Val Arg Leu Leu Gln Ala Phe Leu Glu Arg
                725                 730                 735
Gly Ser Asn Thr Ile Ala Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu
            740                 745                 750
Leu Gly Val Phe Gln Lys Leu Ile Ala Ser Lys Ala Asn Asp His Gln
        755                 760                 765
Gly Phe Tyr Leu Leu Asn Ser Ile Ile Glu His Met Pro Pro Glu Ser
    770                 775                 780
Val Asp Gln Tyr Arg Lys Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu
785                 790                 795                 800
Gln Asn Ser Lys Thr Thr Lys Phe Ile Lys Ser Phe Leu Val Phe Ile
                805                 810                 815
Asn Leu Tyr Cys Ile Lys Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe
            820                 825                 830
Asp Gly Ile Gln Pro Lys Met Phe Gly Met Val Leu Glu Lys Ile Ile
        835                 840                 845
Ile Pro Glu Ile Gln Lys Val Ser Gly Asn Val Glu Lys Lys Ile Cys
    850                 855                 860
Ala Val Gly Ile Thr Asn Leu Leu Thr Glu Cys Pro Pro Met Met Asp
865                 870                 875                 880
Thr Glu Tyr Thr Lys Leu Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly
                885                 890                 895
Leu Phe Glu Leu Pro Glu Asp Asp Thr Ile Pro Asp Glu Glu His Phe
            900                 905                 910
Ile Asp Ile Glu Asp Thr Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu
        915                 920                 925
Ala Phe Ala Gly Lys Lys Glu His Asp Pro Val Gly Gln Met Val Asn
    930                 935                 940
Asn Pro Lys Ile His Leu Ala Gln Ser Leu His Met Leu Ser Thr Ala
945                 950                 955                 960
Cys Pro Gly Arg Val Pro Ser Met Val Ser Thr Ser Leu Asn Ala Glu
                965                 970                 975
Ala Leu Gln Tyr Leu Gln Gly Tyr Leu Gln Ala Ala Ser Val Thr Leu
            980                 985                 990
Leu


<210> 1075
<211> 971
<212> PRT
<213> Homo sapiens

<400> 1075
Met Glu Leu Ser Asp Ala Asn Leu Gln Thr Leu Thr Glu Tyr Leu Lys
 1               5                  10                  15
Lys Thr Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala Glu Lys Phe
            20                  25                  30
Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu Leu Leu Thr
        35                  40                  45
Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys Ala Ser Val
    50                  55                  60
Thr Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val Glu Asp Glu
65                  70                  75                  80
Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys Ala Asn Ile
                85                  90                  95
Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys Gln Leu Ser
            100                 105                 110
Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro
        115                 120                 125
Asp Leu Leu Thr Glu Met Val Asn Arg Phe Gln Ser Gly Asp Phe His
    130                 135                 140
Val Ile Asn Gly Val Leu Arg Thr Ala His Ser Leu Phe Lys Arg Tyr
145                 150                 155                 160
Arg His Glu Phe Lys Ser Asn Glu Leu Trp Thr Glu Ile Lys Leu Val
                165                 170                 175
Leu Asp Ala Phe Ala Leu Pro Leu Thr Asn Leu Phe Lys Ala Thr Ile
            180                 185                 190
Glu Leu Cys Ser Thr His Ala Asn Asp Ala Ser Ala Leu Arg Ile Leu
        195                 200                 205
Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu Phe Tyr Ser Leu Asn Phe
    210                 215                 220
Gln Asp Leu Pro Glu Phe Trp Glu Gly Asn Met Glu Thr Trp Met Asn
225                 230                 235                 240
Asn Phe His Thr Leu Leu Thr Leu Asp Asn Lys Leu Leu Gln Thr Asp
                245                 250                 255
Asp Glu Glu Glu Ala Gly Leu Leu Glu Leu Leu Lys Ser Gln Ile Cys
            260                 265                 270
Asp Asn Ala Ala Leu Tyr Ala Gln Lys Tyr Asp Glu Glu Phe Gln Arg
        275                 280                 285
Tyr Leu Pro Arg Phe Val Thr Ala Ile Trp Asn Leu Leu Val Thr Thr
    290                 295                 300
Gly Gln Glu Val Lys Tyr Asp Leu Leu Val Ser Asn Ala Ile Gln Phe
305                 310                 315                 320
Leu Ala Ser Val Cys Glu Arg Pro His Tyr Lys Asn Leu Phe Glu Asp
                325                 330                 335
Gln Asn Thr Leu Thr Ser Ile Cys Glu Lys Val Ile Val Pro Asn Met
            340                 345                 350
Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe Glu Asp Asn Ser Glu Glu
        355                 360                 365
Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp Ile Asp Thr Arg Arg Arg
    370                 375                 380
Ala Ala Cys Asp Leu Val Arg Gly Leu Cys Lys Phe Phe Glu Gly Pro
385                 390                 395                 400
Val Thr Gly Ile Phe Ser Gly Tyr Val Asn Ser Met Leu Gln Glu Tyr
                405                 410                 415
Ala Lys Asn Pro Ser Val Asn Trp Lys His Lys Asp Ala Ala Ile Tyr
            420                 425                 430
Leu Val Thr Ser Leu Ala Ser Lys Ala Gln Thr Gln Lys His Gly Ile
        435                 440                 445
Thr Gln Ala Asn Glu Leu Val Asn Leu Thr Glu Phe Phe Val Asn His
    450                 455                 460
Ile Leu Pro Asp Leu Lys Ser Ala Asn Val Asn Glu Phe Pro Val Leu
465                 470                 475                 480
Lys Ala Asp Gly Ile Lys Tyr Ile Met Ile Phe Arg Asn Gln Val Pro
                485                 490                 495
Lys Glu His Leu Leu Val Ser Ile Pro Leu Leu Ile Asn His Leu Gln
            500                 505                 510
Ala Gly Ser Ile Val Val His Thr Tyr Ala Ala His Ala Leu Glu Arg
        515                 520                 525
Leu Phe Thr Met Arg Gly Pro Asn Asn Ala Thr Leu Phe Thr Ala Ala
    530                 535                 540
Glu Ile Ala Pro Phe Val Glu Ile Leu Leu Thr Asn Leu Phe Lys Ala
545                 550                 555                 560
Leu Thr Leu Pro Gly Ser Ser Glu Asn Glu Tyr Ile Met Lys Ala Ile
                565                 570                 575
Met Arg Ser Phe Ser Leu Leu Gln Glu Ala Ile Ile Pro Tyr Ile Pro
            580                 585                 590
Thr Leu Ile Thr Gln Leu Thr Gln Lys Leu Leu Ala Val Ser Lys Asn
        595                 600                 605
Pro Ser Lys Pro His Phe Asn His Tyr Met Phe Glu Ala Ile Cys Leu
    610                 615                 620
Ser Ile Arg Ile Thr Cys Lys Ala Asn Pro Ala Ala Val Val Asn Phe
625                 630                 635                 640
Glu Glu Ala Leu Phe Leu Val Phe Thr Glu Ile Leu Gln Asn Asp Val
                645                 650                 655
Gln Glu Phe Ile Pro Tyr Val Phe Gln Val Met Ser Leu Leu Leu Glu
            660                 665                 670
Thr His Lys Asn Asp Ile Pro Ser Ser Tyr Met Ala Leu Phe Pro His
        675                 680                 685
Leu Leu Gln Pro Val Leu Trp Glu Arg Thr Gly Asn Ile Pro Ala Leu
    690                 695                 700
Val Arg Leu Leu Gln Ala Phe Leu Glu Arg Gly Ser Asn Thr Ile Ala
705                 710                 715                 720
Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu Leu Gly Val Phe Gln Lys
                725                 730                 735
Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu Leu Asn
            740                 745                 750
Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr Arg Lys
        755                 760                 765
Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys Thr Thr
    770                 775                 780
Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys Ile Lys
785                 790                 795                 800
Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln Pro Lys
                805                 810                 815
Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile Gln Lys
            820                 825                 830
Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile Thr Asn
        835                 840                 845
Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr Lys Leu
    850                 855                 860
Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu Pro Glu
865                 870                 875                 880
Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu Asp Thr
                885                 890                 895
Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly Lys Lys
            900                 905                 910
Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile His Leu
        915                 920                 925
Ala Gln Ser Leu His Met Leu Ser Thr Ala Cys Pro Gly Arg Val Pro
    930                 935                 940
Ser Met Val Ser Thr Ser Leu Asn Ala Glu Ala Leu Gln Tyr Leu Gln
945                 950                 955                 960
Gly Tyr Leu Gln Ala Ala Ser Val Thr Leu Leu
                965                 970

<210> 1076
<211> 971
<212> PRT
<213> Homo sapiens

<400> 1076
Met Glu Leu Ser Asp Ala Asn Leu Gln Thr Leu Thr Glu Tyr Leu Lys
 1               5                  10                  15
Lys Thr Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala Glu Lys Phe
            20                  25                  30
Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu Leu Leu Thr
        35                  40                  45
Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys Ala Ser Val
    50                  55                  60
Thr Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val Glu Asp Glu
65                  70                  75                  80
Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys Ala Asn Ile
                85                  90                  95
Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys Gln Leu Ser
            100                 105                 110
Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro
        115                 120                 125
Asp Leu Leu Thr Glu Met Val Asn Arg Phe Gln Ser Gly Asp Phe His
    130                 135                 140
Val Ile Asn Gly Val Leu Arg Thr Ala His Ser Leu Phe Lys Arg Tyr
145                 150                 155                 160
Arg His Glu Phe Lys Ser Asn Glu Leu Trp Thr Glu Ile Lys Leu Val
                165                 170                 175
Leu Asp Ala Phe Ala Leu Pro Leu Thr Asn Leu Phe Lys Ala Thr Ile
            180                 185                 190
Glu Leu Cys Ser Thr His Ala Asn Asp Ala Ser Ala Leu Arg Ile Leu
        195                 200                 205
Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu Phe Tyr Ser Leu Asn Phe
    210                 215                 220
Gln Asp Leu Pro Glu Phe Trp Glu Gly Asn Met Glu Thr Trp Met Asn
225                 230                 235                 240
Asn Phe His Thr Leu Leu Thr Leu Asp Asn Lys Leu Leu Gln Thr Asp
                245                 250                 255
Asp Glu Glu Glu Ala Gly Leu Leu Glu Leu Leu Lys Ser Gln Ile Cys
            260                 265                 270
Asp Asn Ala Ala Leu Tyr Ala Gln Lys Tyr Asp Glu Glu Phe Gln Arg
        275                 280                 285
Tyr Leu Pro Arg Phe Val Thr Ala Ile Trp Asn Leu Leu Val Thr Thr
    290                 295                 300
Gly Gln Glu Val Lys Tyr Asp Leu Leu Val Ser Asn Ala Ile Gln Phe
305                 310                 315                 320
Leu Ala Ser Val Cys Glu Arg Pro His Tyr Lys Asn Leu Phe Glu Asp
                325                 330                 335
Gln Asn Thr Leu Thr Ser Ile Cys Glu Lys Val Ile Val Pro Asn Met
            340                 345                 350
Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe Glu Asp Asn Ser Glu Glu
        355                 360                 365
Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp Ile Asp Thr Arg Arg Arg
    370                 375                 380
Ala Ala Cys Asp Leu Val Arg Gly Leu Cys Lys Phe Phe Glu Gly Pro
385                 390                 395                 400
Val Thr Gly Ile Phe Ser Gly Tyr Val Asn Ser Met Leu Gln Glu Tyr
                405                 410                 415
Ala Lys Asn Pro Ser Val Asn Trp Lys His Lys Asp Ala Ala Ile Tyr
            420                 425                 430
Leu Val Thr Ser Leu Ala Ser Lys Ala Gln Thr Gln Lys His Gly Ile
        435                 440                 445
Thr Gln Ala Asn Glu Leu Val Asn Leu Thr Glu Phe Phe Val Asn His
    450                 455                 460
Ile Leu Pro Asp Leu Lys Ser Ala Asn Val Asn Glu Phe Pro Val Leu
465                 470                 475                 480
Lys Ala Asp Gly Ile Lys Tyr Ile Met Ile Phe Arg Asn Gln Val Pro
                485                 490                 495
Lys Glu His Leu Leu Val Ser Ile Pro Leu Leu Ile Asn His Leu Gln
            500                 505                 510
Ala Gly Ser Ile Val Val His Thr Tyr Ala Ala His Ala Leu Glu Arg
        515                 520                 525
Leu Phe Thr Met Arg Gly Pro Asn Asn Ala Thr Leu Phe Thr Ala Ala
    530                 535                 540
Glu Ile Ala Pro Phe Val Glu Ile Leu Leu Thr Asn Leu Phe Lys Ala
545                 550                 555                 560
Leu Thr Leu Pro Gly Ser Ser Glu Asn Glu Tyr Ile Met Lys Ala Ile
                565                 570                 575
Met Arg Ser Phe Ser Leu Leu Gln Glu Ala Ile Ile Pro Tyr Ile Pro
            580                 585                 590
Thr Leu Ile Thr Gln Leu Thr Gln Lys Leu Leu Ala Val Ser Lys Asn
        595                 600                 605
Pro Ser Lys Pro His Phe Asn His Tyr Met Phe Glu Ala Ile Cys Leu
    610                 615                 620
Ser Ile Arg Ile Thr Cys Lys Ala Asn Pro Ala Ala Val Val Asn Phe
625                 630                 635                 640
Glu Glu Ala Leu Phe Leu Val Phe Thr Glu Ile Leu Gln Asn Asp Val
                645                 650                 655
Gln Glu Phe Ile Pro Tyr Val Phe Gln Val Met Ser Leu Leu Leu Glu
            660                 665                 670
Thr His Lys Asn Asp Ile Pro Ser Ser Tyr Met Ala Leu Phe Pro His
        675                 680                 685
Leu Leu Gln Pro Val Leu Trp Glu Arg Thr Gly Asn Ile Pro Ala Leu
    690                 695                 700
Val Arg Leu Leu Gln Ala Phe Leu Glu Arg Gly Ser Asn Thr Ile Ala
705                 710                 715                 720
Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu Leu Gly Val Phe Gln Lys
                725                 730                 735
Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu Leu Asn
            740                 745                 750
Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr Arg Lys
        755                 760                 765
Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys Thr Thr
    770                 775                 780
Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys Ile Lys
785                 790                 795                 800
Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln Pro Lys
                805                 810                 815
Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile Gln Lys
            820                 825                 830
Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile Thr Asn
        835                 840                 845
Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr Lys Leu
    850                 855                 860
Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu Pro Glu
865                 870                 875                 880
Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu Asp Thr
                885                 890                 895
Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly Lys Lys
            900                 905                 910
Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile His Leu
        915                 920                 925
Ala Gln Ser Leu His Met Leu Ser Thr Ala Cys Pro Gly Arg Val Pro
    930                 935                 940
Ser Met Val Ser Thr Ser Leu Asn Ala Glu Ala Leu Gln Tyr Leu Gln
945                 950                 955                 960
Gly Tyr Leu Gln Ala Ala Ser Val Thr Leu Leu
                965                 970

<210> 1077
<211> 971
<212> PRT
<213> Homo sapiens

<400> 1077
Met Glu Leu Ser Asp Ala Asn Leu Gln Thr Leu Thr Glu Tyr Leu Lys
 1               5                  10                  15
Lys Thr Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala Glu Lys Phe
            20                  25                  30
Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu Leu Leu Thr
        35                  40                  45
Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys Ala Ser Val
    50                  55                  60
Thr Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val Glu Asp Glu
65                  70                  75                  80
Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys Ala Asn Ile
                85                  90                  95
Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys Gln Leu Ser
            100                 105                 110
Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro
        115                 120                 125
Asp Leu Leu Thr Glu Met Val Asn Arg Phe Gln Ser Gly Asp Phe His
    130                 135                 140
Val Ile Asn Gly Val Leu Arg Thr Ala His Ser Leu Phe Lys Arg Tyr
145                 150                 155                 160
Arg His Glu Phe Lys Ser Asn Glu Leu Trp Thr Glu Ile Lys Leu Val
                165                 170                 175
Leu Asp Ala Phe Ala Leu Pro Leu Thr Asn Leu Phe Lys Ala Thr Ile
            180                 185                 190
Glu Leu Cys Ser Thr His Ala Asn Asp Ala Ser Ala Leu Arg Ile Leu
        195                 200                 205
Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu Phe Tyr Ser Leu Asn Phe
    210                 215                 220
Gln Asp Leu Pro Glu Phe Trp Glu Gly Asn Met Glu Thr Trp Met Asn
225                 230                 235                 240
Asn Phe His Thr Leu Leu Thr Leu Asp Asn Lys Leu Leu Gln Thr Asp
                245                 250                 255
Asp Glu Glu Glu Ala Gly Leu Leu Glu Leu Leu Lys Ser Gln Ile Cys
            260                 265                 270
Asp Asn Ala Ala Leu Tyr Ala Gln Lys Tyr Asp Glu Glu Phe Gln Arg
        275                 280                 285
Tyr Leu Pro Arg Phe Val Thr Ala Ile Trp Asn Leu Leu Val Thr Thr
    290                 295                 300
Gly Gln Glu Val Lys Tyr Asp Leu Leu Val Ser Asn Ala Ile Gln Phe
305                 310                 315                 320
Leu Ala Ser Val Cys Glu Arg Pro His Tyr Lys Asn Leu Phe Glu Asp
                325                 330                 335
Gln Asn Thr Leu Thr Ser Ile Cys Glu Lys Val Ile Val Pro Asn Met
            340                 345                 350
Glu Phe Arg Ala Ala Asp Glu Glu Ala Phe Glu Asp Asn Ser Glu Glu
        355                 360                 365
Tyr Ile Arg Arg Asp Leu Glu Gly Ser Asp Ile Asp Thr Arg Arg Arg
    370                 375                 380
Ala Ala Cys Asp Leu Val Arg Gly Leu Cys Lys Phe Phe Glu Gly Pro
385                 390                 395                 400
Val Thr Gly Ile Phe Ser Gly Tyr Val Asn Ser Met Leu Gln Glu Tyr
                405                 410                 415
Ala Lys Asn Pro Ser Val Asn Trp Lys His Lys Asp Ala Ala Ile Tyr
            420                 425                 430
Leu Val Thr Ser Leu Ala Ser Lys Ala Gln Thr Gln Lys His Gly Ile
        435                 440                 445
Thr Gln Ala Asn Glu Leu Val Asn Leu Thr Glu Phe Phe Val Asn His
    450                 455                 460
Ile Leu Pro Asp Leu Lys Ser Ala Asn Val Asn Glu Phe Pro Val Leu
465                 470                 475                 480
Lys Ala Asp Gly Ile Lys Tyr Ile Met Ile Phe Arg Asn Gln Val Pro
                485                 490                 495
Lys Glu His Leu Leu Val Ser Ile Pro Leu Leu Ile Asn His Leu Gln
            500                 505                 510
Ala Gly Ser Ile Val Val His Thr Tyr Ala Ala His Ala Leu Glu Arg
        515                 520                 525
Leu Phe Thr Met Arg Gly Pro Asn Asn Ala Thr Leu Phe Thr Ala Ala
    530                 535                 540
Glu Ile Ala Pro Phe Val Glu Ile Leu Leu Thr Asn Leu Phe Lys Ala
545                 550                 555                 560
Leu Thr Leu Pro Gly Ser Ser Glu Asn Glu Tyr Ile Met Lys Ala Ile
                565                 570                 575
Met Arg Ser Phe Ser Leu Leu Gln Glu Ala Ile Ile Pro Tyr Ile Pro
            580                 585                 590
Thr Leu Ile Thr Gln Leu Thr Gln Lys Leu Leu Ala Val Ser Lys Asn
        595                 600                 605
Pro Ser Lys Pro His Phe Asn His Tyr Met Phe Glu Ala Ile Cys Leu
    610                 615                 620
Ser Ile Arg Ile Thr Cys Lys Ala Asn Pro Ala Ala Val Val Asn Phe
625                 630                 635                 640
Glu Glu Ala Leu Phe Leu Val Phe Thr Glu Ile Leu Gln Asn Asp Val
                645                 650                 655
Gln Glu Phe Ile Pro Tyr Val Phe Gln Val Met Ser Leu Leu Leu Glu
            660                 665                 670
Thr His Lys Asn Asp Ile Pro Ser Ser Tyr Met Ala Leu Phe Pro His
        675                 680                 685
Leu Leu Gln Pro Val Leu Trp Glu Arg Thr Gly Asn Ile Pro Ala Leu
    690                 695                 700
Val Arg Leu Leu Gln Ala Phe Leu Glu Arg Gly Ser Asn Thr Ile Ala
705                 710                 715                 720
Ser Ala Ala Ala Asp Lys Ile Pro Gly Leu Leu Gly Val Phe Gln Lys
                725                 730                 735
Leu Ile Ala Ser Lys Ala Asn Asp His Gln Gly Phe Tyr Leu Leu Asn
            740                 745                 750
Ser Ile Ile Glu His Met Pro Pro Glu Ser Val Asp Gln Tyr Arg Lys
        755                 760                 765
Gln Ile Phe Ile Leu Leu Phe Gln Arg Leu Gln Asn Ser Lys Thr Thr
    770                 775                 780
Lys Phe Ile Lys Ser Phe Leu Val Phe Ile Asn Leu Tyr Cys Ile Lys
785                 790                 795                 800
Tyr Gly Ala Leu Ala Leu Gln Glu Ile Phe Asp Gly Ile Gln Pro Lys
                805                 810                 815
Met Phe Gly Met Val Leu Glu Lys Ile Ile Ile Pro Glu Ile Gln Lys
            820                 825                 830
Val Ser Gly Asn Val Glu Lys Lys Ile Cys Ala Val Gly Ile Thr Lys
        835                 840                 845
Leu Leu Thr Glu Cys Pro Pro Met Met Asp Thr Glu Tyr Thr Lys Leu
    850                 855                 860
Trp Thr Pro Leu Leu Gln Ser Leu Ile Gly Leu Phe Glu Leu Pro Glu
865                 870                 875                 880
Asp Asp Thr Ile Pro Asp Glu Glu His Phe Ile Asp Ile Glu Asp Thr
                885                 890                 895
Pro Gly Tyr Gln Thr Ala Phe Ser Gln Leu Ala Phe Ala Gly Lys Lys
            900                 905                 910
Glu His Asp Pro Val Gly Gln Met Val Asn Asn Pro Lys Ile His Leu
        915                 920                 925
Ala Gln Ser Leu His Lys Leu Ser Thr Ala Cys Pro Gly Arg Val Pro
    930                 935                 940
Ser Met Val Ser Thr Ser Leu Asn Ala Glu Ala Leu Gln Tyr Leu Gln
945                 950                 955                 960
Gly Tyr Leu Gln Ala Ala Ser Val Thr Leu Leu
                965                 970

<210> 1078
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1078
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1079
<211> 315
<212> PRT
<213> Homo sapiens

<400> 1079
Met Ser Leu Glu Gln Arg Ser Pro His Cys Lys Pro Asp Glu Asp Leu
 1               5                  10                  15
Glu Ala Gln Gly Glu Asp Leu Gly Leu Met Gly Ala Gln Glu Pro Thr
            20                  25                  30
Gly Glu Glu Glu Glu Thr Thr Ser Ser Ser Asp Ser Lys Glu Glu Glu
        35                  40                  45
Val Ser Ala Ala Gly Ser Ser Ser Pro Pro Gln Ser Pro Gln Gly Gly
    50                  55                  60
Ala Ser Ser Ser Ile Ser Val Tyr Tyr Thr Leu Trp Ser Gln Phe Asp
65                  70                  75                  80
Glu Gly Ser Ser Ser Gln Glu Glu Glu Glu Pro Ser Ser Ser Val Asp
                85                  90                  95
Pro Ala Gln Leu Glu Phe Met Phe Gln Glu Ala Leu Lys Leu Lys Val
            100                 105                 110
Ala Glu Leu Val His Phe Leu Leu His Lys Tyr Arg Val Lys Glu Pro
        115                 120                 125
Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys Asn Tyr Lys Arg
    130                 135                 140
Tyr Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Phe Met Gln Val Ile
145                 150                 155                 160
Phe Gly Thr Asp Val Lys Glu Val Asp Pro Ala Gly His Ser Tyr Ile
                165                 170                 175
Leu Val Thr Ala Leu Gly Leu Ser Cys Asp Ser Met Leu Gly Asp Gly
            180                 185                 190
His Ser Met Pro Lys Ala Ala Leu Leu Ile Ile Val Leu Gly Val Ile
        195                 200                 205
Leu Thr Lys Asp Asn Cys Ala Pro Glu Glu Val Ile Trp Glu Ala Leu
    210                 215                 220
Ser Val Met Gly Val Tyr Val Gly Lys Glu His Met Phe Tyr Gly Glu
225                 230                 235                 240
Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu
                245                 250                 255
Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala His Tyr Glu Phe Leu Trp
            260                 265                 270
Gly Ser Lys Ala His Ala Glu Thr Ser Tyr Glu Lys Val Ile Asn Tyr
        275                 280                 285
Leu Val Met Leu Asn Ala Arg Glu Pro Ile Cys Tyr Pro Ser Leu Tyr
    290                 295                 300
Glu Glu Val Leu Gly Glu Glu Gln Glu Gly Val
305                 310                 315

<210> 1080
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1080
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1081
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1081
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1082
<211> 315
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(315)
<223> Xaa = Any Amino Acid

<400> 1082
Met Ser Leu Glu Gln Arg Ser Pro His Cys Lys Pro Asp Glu Asp Leu
 1               5                  10                  15
Glu Ala Gln Gly Glu Asp Leu Gly Leu Met Gly Ala Gln Glu Pro Thr
            20                  25                  30
Gly Glu Glu Glu Glu Thr Thr Ser Ser Ser Asp Ser Lys Glu Glu Glu
        35                  40                  45
Val Ser Ala Ala Gly Ser Ser Ser Pro Pro Gln Ser Pro Gln Gly Gly
    50                  55                  60
Ala Ser Ser Ser Ile Ser Val Tyr Tyr Thr Leu Trp Ser Gln Phe Asp
65                  70                  75                  80
Glu Gly Ser Ser Ser Gln Glu Glu Glu Glu Pro Ser Ser Ser Val Asp
                85                  90                  95
Pro Ala Gln Leu Glu Phe Met Phe Gln Glu Ala Leu Lys Leu Lys Val
            100                 105                 110
Ala Glu Leu Val His Phe Leu Leu His Lys Tyr Arg Val Lys Glu Pro
        115                 120                 125
Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys Asn Tyr Lys Arg
    130                 135                 140
Tyr Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Phe Met Gln Val Ile
145                 150                 155                 160
Phe Gly Thr Asp Val Xaa Glu Val Asp Pro Ala Gly His Ser Tyr Ile
                165                 170                 175
Leu Val Thr Ala Leu Gly Leu Ser Cys Asp Ser Met Leu Gly Asp Gly
            180                 185                 190
His Ser Met Pro Lys Ala Ala Leu Leu Ile Ile Val Leu Gly Val Ile
        195                 200                 205
Leu Thr Lys Asp Asn Cys Ala Pro Glu Glu Val Ile Trp Glu Ala Leu
    210                 215                 220
Ser Val Met Gly Val Tyr Val Gly Lys Glu His Met Phe Tyr Gly Glu
225                 230                 235                 240
Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu
                245                 250                 255
Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala His Tyr Glu Phe Leu Trp
            260                 265                 270
Gly Ser Lys Ala His Ala Glu Thr Ser Tyr Glu Lys Val Ile Asn Tyr
        275                 280                 285
Leu Val Met Leu Asn Ala Arg Glu Pro Ile Cys Tyr Pro Ser Leu Tyr
    290                 295                 300
Glu Glu Val Leu Gly Glu Glu Gln Glu Gly Val
305                 310                 315

<210> 1083
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1083
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1084
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1084
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1085
<211> 316
<212> PRT
<213> Homo sapiens

<400> 1085
Met Ser Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Phe Thr Lys Ala Glu Met Leu Gly Ser Val Ile Arg Asn Phe Gln
    130                 135                 140
Asp Phe Phe Pro Val Ile Phe Ser Glu Ala Ser Glu Tyr Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Val Val Glu Val Val Arg Ile Gly His Leu Tyr
                165                 170                 175
Ile Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Thr Gly Phe Leu Ile Ile Val Leu Val Met
        195                 200                 205
Ile Ala Met Glu Gly Gly His Ala Pro Glu Glu Glu Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Met Glu Val Tyr Asp Gly Arg Glu His Ser Ala Tyr Gly
225                 230                 235                 240
Glu Pro Arg Lys Leu Leu Thr Gln Asp Leu Val Gln Glu Lys Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Asp Ser Asp Pro Ala Arg Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu Glu
        275                 280                 285
Tyr Val Ile Lys Val Ser Ala Arg Val Arg Phe Phe Phe Pro Ser Leu
    290                 295                 300
Arg Glu Ala Ala Leu Arg Glu Glu Glu Glu Gly Val
305                 310                 315

<210> 1086
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1086
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1087
<211> 315
<212> PRT
<213> Homo sapiens

<400> 1087
Met Ser Leu Glu Gln Arg Ser Pro His Cys Lys Pro Asp Glu Asp Leu
 1               5                  10                  15
Glu Ala Gln Gly Glu Asp Leu Gly Leu Met Gly Ala Gln Glu Pro Thr
            20                  25                  30
Gly Glu Glu Glu Glu Thr Thr Ser Ser Ser Asp Ser Lys Glu Glu Glu
        35                  40                  45
Val Ser Ala Ala Gly Ser Ser Ser Pro Pro Gln Ser Pro Gln Gly Gly
    50                  55                  60
Ala Ser Ser Ser Ile Ser Val Tyr Tyr Thr Leu Trp Ser Gln Phe Asp
65                  70                  75                  80
Glu Gly Ser Ser Ser Gln Glu Glu Glu Glu Pro Ser Ser Ser Val Asp
                85                  90                  95
Pro Ala Gln Leu Glu Phe Met Phe Gln Glu Ala Leu Lys Leu Lys Val
            100                 105                 110
Ala Glu Leu Val His Phe Leu Leu His Lys Tyr Arg Val Lys Glu Pro
        115                 120                 125
Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys Asn Tyr Lys Arg
    130                 135                 140
Tyr Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Phe Met Gln Val Ile
145                 150                 155                 160
Phe Gly Thr Asp Val Lys Glu Val Asp Pro Ala Gly His Ser Tyr Ile
                165                 170                 175
Leu Val Thr Ala Leu Gly Leu Ser Cys Asp Ser Met Leu Gly Asp Gly
            180                 185                 190
His Ser Met Pro Lys Ala Ala Leu Leu Ile Ile Val Leu Gly Val Ile
        195                 200                 205
Leu Thr Lys Asp Asn Cys Ala Pro Glu Glu Val Ile Trp Glu Ala Leu
    210                 215                 220
Ser Val Met Gly Val Tyr Val Gly Lys Glu His Met Phe Tyr Gly Glu
225                 230                 235                 240
Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu
                245                 250                 255
Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala His Tyr Glu Phe Leu Trp
            260                 265                 270
Gly Ser Lys Ala His Ala Glu Thr Ser Tyr Glu Lys Val Ile Asn Tyr
        275                 280                 285
Leu Val Met Leu Asn Ala Arg Glu Pro Ile Cys Tyr Pro Ser Leu Tyr
    290                 295                 300
Glu Glu Val Leu Gly Glu Glu Gln Glu Gly Val
305                 310                 315

<210> 1088
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1088
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1089
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1089
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1090
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1090
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala
 1               5                  10                  15

<210> 1091
<211> 315
<212> PRT
<213> Homo sapiens

<400> 1091
Met Ser Leu Glu Gln Arg Ser Pro His Cys Lys Pro Asp Glu Asp Leu
 1               5                  10                  15
Glu Ala Gln Gly Glu Asp Leu Gly Leu Met Gly Ala Gln Glu Pro Thr
            20                  25                  30
Gly Glu Glu Glu Glu Thr Thr Ser Ser Ser Asp Ser Lys Glu Glu Glu
        35                  40                  45
Val Ser Ala Ala Gly Ser Ser Ser Pro Pro Gln Ser Pro Gln Gly Gly
    50                  55                  60
Ala Ser Ser Ser Ile Ser Val Tyr Tyr Thr Leu Trp Ser Gln Phe Asp
65                  70                  75                  80
Glu Gly Ser Ser Ser Gln Glu Glu Glu Glu Pro Ser Ser Ser Val Asp
                85                  90                  95
Pro Ala Gln Leu Glu Phe Met Phe Gln Glu Ala Leu Lys Leu Lys Val
            100                 105                 110
Ala Glu Leu Val His Phe Leu Leu His Lys Tyr Arg Val Lys Glu Pro
        115                 120                 125
Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys Asn Tyr Lys Arg
    130                 135                 140
Tyr Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Phe Met Gln Val Ile
145                 150                 155                 160
Phe Gly Thr Asp Val Lys Glu Val Asp Pro Ala Gly His Ser Tyr Ile
                165                 170                 175
Leu Val Thr Ala Leu Gly Leu Ser Cys Asp Ser Met Leu Gly Asp Gly
            180                 185                 190
His Ser Met Pro Lys Ala Ala Leu Leu Ile Ile Val Leu Gly Val Ile
        195                 200                 205
Leu Thr Lys Asp Asn Cys Ala Pro Glu Glu Val Ile Trp Glu Ala Leu
    210                 215                 220
Ser Val Met Gly Val Tyr Val Gly Lys Glu His Met Phe Tyr Gly Glu
225                 230                 235                 240
Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu
                245                 250                 255
Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala His Tyr Glu Phe Leu Trp
            260                 265                 270
Gly Ser Lys Ala His Ala Glu Thr Ser Tyr Glu Lys Val Ile Asn Tyr
        275                 280                 285
Leu Val Met Leu Asn Ala Arg Glu Pro Ile Cys Tyr Pro Ser Leu Tyr
    290                 295                 300
Glu Glu Val Leu Gly Glu Glu Gln Glu Gly Val
305                 310                 315

<210> 1092
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1092
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg
 1               5                  10                  15

<210> 1093
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1093
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1094
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1094
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1095
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1095
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1096
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1096
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1097
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1097
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1098
<211> 221
<212> PRT
<213> Homo sapiens

<400> 1098
Gly Pro Ser Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu
 1               5                  10                  15
Ser Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg
            20                  25                  30
Ala Arg Glu Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly
        35                  40                  45
Asn Trp Gln Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser
    50                  55                  60
Leu Gln Leu Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly
65                  70                  75                  80
His Leu Tyr Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu
                85                  90                  95
Leu Gly Asp Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val
            100                 105                 110
Leu Ala Ile Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile
        115                 120                 125
Trp Glu Glu Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser
    130                 135                 140
Ile Leu Gly Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu
145                 150                 155                 160
Asn Tyr Leu Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr
                165                 170                 175
Glu Phe Leu Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys
            180                 185                 190
Val Leu His His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr
        195                 200                 205
Pro Pro Leu His Glu Trp Val Leu Arg Glu Gly Glu Glu
    210                 215                 220

<210> 1099
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1099
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1100
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1100
Gln Ala Ala Leu Ser Arg Lys Val Ala Glu Leu Val His Phe Leu
 1               5                  10                  15

<210> 1101
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1101
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1102
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1102
Lys Val Ala Glu Leu Val His Phe Leu Leu
 1               5                  10

<210> 1103
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1103
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1104
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1104
Lys Val Ala Glu Leu Val His Phe Leu Leu
 1               5                  10

<210> 1105
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1105
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1106
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1106
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1107
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1107
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1108
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1108
Lys Val Ala Glu Leu Val His Phe Leu Leu
 1               5                  10

<210> 1109
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1109
Lys Val Ala Glu Leu Val His Phe Leu Leu
 1               5                  10

<210> 1110
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1110
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1111
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1111
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1112
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1112
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala
 1               5                  10                  15

<210> 1113
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1113
Met Asp Pro Lys Thr Leu Ala Leu Ser Leu Leu Ala Ala Gly Val Leu
 1               5                  10                  15
Ala Gly Cys Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln Met Lys
            20                  25                  30
Ser Asp Lys Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr Leu Pro
        35                  40                  45
Glu His Thr Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln Gln Ala Asp
    50                  55                  60
Tyr Leu Glu Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu Val Val
65                  70                  75                  80
Ile His Asp His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys Lys Phe
                85                  90                  95
Pro His Arg His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp Phe Thr
            100                 105                 110
Leu Lys Glu Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu Thr Met
        115                 120                 125
Asp Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu Glu
    130                 135                 140
Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala Thr
145                 150                 155                 160
Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val Thr
                165                 170                 175
Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser Pro
            180                 185                 190
Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp Ser
        195                 200                 205
Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser Thr
    210                 215                 220
Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys Val
225                 230                 235                 240
Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro
                245                 250                 255
Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln Tyr
            260                 265                 270
Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu Val
        275                 280                 285
Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr Ile
    290                 295                 300
Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn
305                 310                 315                 320
Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile Ile
                325                 330                 335
Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu Leu
            340                 345                 350
Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly Asp
        355                 360                 365
Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu
    370                 375                 380
Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu Trp
385                 390                 395                 400
Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His His
                405                 410                 415
Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu His
            420                 425                 430
Glu Trp Val Leu Arg Glu Gly Glu Glu Thr Ser Gly Gly His His His
        435                 440                 445
His His His
    450

<210> 1114
<211> 403
<212> PRT
<213> Homo sapiens

<400> 1114
Met Asp Pro Asn Thr Val Ser Ser Phe Gln Val Asp Cys Phe Leu Trp
 1               5                  10                  15
His Val Arg Lys Arg Val Ala Asp Gln Glu Leu Gly Asp Ala Pro Phe
            20                  25                  30
Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly Arg Gly Ser
        35                  40                  45
Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr Arg Ala Gly Lys Gln Ile
    50                  55                  60
Val Glu Arg Ile Leu Lys Glu Glu Ser Asp Glu Ala Leu Lys Met Thr
65                  70                  75                  80
Met Asp Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
                85                  90                  95
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            100                 105                 110
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        115                 120                 125
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    130                 135                 140
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
145                 150                 155                 160
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                165                 170                 175
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            180                 185                 190
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        195                 200                 205
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    210                 215                 220
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
225                 230                 235                 240
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                245                 250                 255
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            260                 265                 270
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        275                 280                 285
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    290                 295                 300
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
305                 310                 315                 320
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                325                 330                 335
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            340                 345                 350
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        355                 360                 365
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    370                 375                 380
His Glu Trp Val Leu Arg Glu Gly Glu Glu Gly Gly His His His His
385                 390                 395                 400
His His His


<210> 1115
<211> 453
<212> PRT
<213> Homo sapiens

<400> 1115
Met Lys Gly Gly Ile Val His Ser Asp Gly Ser Tyr Pro Lys Asp Lys
 1               5                  10                  15
Phe Glu Lys Ile Asn Gly Thr Trp Tyr Tyr Phe Asp Ser Ser Gly Tyr
            20                  25                  30
Met Leu Ala Asp Arg Trp Arg Lys His Thr Asp Gly Asn Trp Tyr Trp
        35                  40                  45
Phe Asp Asn Ser Gly Glu Met Ala Thr Gly Trp Lys Lys Ile Ala Asp
    50                  55                  60
Lys Trp Tyr Tyr Phe Asn Glu Glu Gly Ala Met Lys Thr Gly Trp Val
65                  70                  75                  80
Lys Tyr Lys Asp Thr Trp Tyr Tyr Leu Asp Ala Lys Glu Gly Ala Met
                85                  90                  95
Val Ser Asn Ala Phe Ile Gln Ser Ala Asp Gly Thr Gly Trp Tyr Tyr
            100                 105                 110
Leu Lys Pro Asp Gly Thr Leu Ala Asp Arg Pro Glu Leu Ala Ser Met
        115                 120                 125
Leu Asp Met Asp Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu
    130                 135                 140
Gly Leu Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala
145                 150                 155                 160
Pro Ala Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val
                165                 170                 175
Glu Val Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro
            180                 185                 190
Gln Ser Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro
        195                 200                 205
Leu Trp Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly
    210                 215                 220
Pro Ser Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser
225                 230                 235                 240
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala
                245                 250                 255
Arg Glu Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn
            260                 265                 270
Trp Gln Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu
        275                 280                 285
Gln Leu Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His
    290                 295                 300
Leu Tyr Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu
305                 310                 315                 320
Gly Asp Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu
                325                 330                 335
Ala Ile Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp
            340                 345                 350
Glu Glu Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile
        355                 360                 365
Leu Gly Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn
    370                 375                 380
Tyr Leu Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu
385                 390                 395                 400
Phe Leu Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val
                405                 410                 415
Leu His His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro
            420                 425                 430
Pro Leu His Glu Trp Val Leu Arg Glu Gly Glu Glu Gly Gly His His
        435                 440                 445
His His His His His
    450

<210> 1116
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1116
Lys Val Ala Glu Leu Val His Phe Leu Leu
 1               5                  10

<210> 1117
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1117
Lys Val Ala Glu Leu Val His Phe Leu
 1               5

<210> 1118
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1118
Ala Ala Leu Ser Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu
 1               5                  10                  15

<210> 1119
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1119
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1120
<211> 315
<212> PRT
<213> Homo sapiens

<400> 1120
Met Ser Leu Glu Gln Arg Ser Pro His Cys Lys Pro Asp Glu Asp Leu
 1               5                  10                  15
Glu Ala Gln Gly Glu Asp Leu Gly Leu Met Gly Ala Gln Glu Pro Thr
            20                  25                  30
Gly Glu Glu Glu Glu Thr Thr Ser Ser Ser Asp Ser Lys Glu Glu Glu
        35                  40                  45
Val Ser Ala Ala Gly Ser Ser Ser Pro Pro Gln Ser Pro Gln Gly Gly
    50                  55                  60
Ala Ser Ser Ser Ile Ser Val Tyr Tyr Thr Leu Trp Ser Gln Phe Asp
65                  70                  75                  80
Glu Gly Ser Ser Ser Gln Glu Glu Glu Glu Pro Ser Ser Ser Val Asp
                85                  90                  95
Pro Ala Gln Leu Glu Phe Met Phe Gln Glu Ala Leu Lys Leu Lys Val
            100                 105                 110
Ala Glu Leu Val His Phe Leu Leu His Lys Tyr Arg Val Lys Glu Pro
        115                 120                 125
Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys Asn Tyr Lys Arg
    130                 135                 140
Tyr Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Phe Met Gln Val Ile
145                 150                 155                 160
Phe Gly Thr Asp Val Lys Glu Val Asp Pro Ala Gly His Ser Tyr Ile
                165                 170                 175
Leu Val Thr Ala Leu Gly Leu Ser Cys Asp Ser Met Leu Gly Asp Gly
            180                 185                 190
His Ser Met Pro Lys Ala Ala Leu Leu Ile Ile Val Leu Gly Val Ile
        195                 200                 205
Leu Thr Lys Asp Asn Cys Ala Pro Glu Glu Val Ile Trp Glu Ala Leu
    210                 215                 220
Ser Val Met Gly Val Tyr Val Gly Lys Glu His Met Phe Tyr Gly Glu
225                 230                 235                 240
Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu
                245                 250                 255
Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala His Tyr Glu Phe Leu Trp
            260                 265                 270
Gly Ser Lys Ala His Ala Glu Thr Ser Tyr Glu Lys Val Ile Asn Tyr
        275                 280                 285
Leu Val Met Leu Asn Ala Arg Glu Pro Ile Cys Tyr Pro Ser Leu Tyr
    290                 295                 300
Glu Glu Val Leu Gly Glu Glu Gln Glu Gly Val
305                 310                 315

<210> 1121
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1121
Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu
 1               5                  10                  15
Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala
            20                  25                  30
Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val
        35                  40                  45
Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser
    50                  55                  60
Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp
65                  70                  75                  80
Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser
                85                  90                  95
Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys
            100                 105                 110
Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu
        115                 120                 125
Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln
    130                 135                 140
Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu
145                 150                 155                 160
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr
                165                 170                 175
Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp
            180                 185                 190
Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile
        195                 200                 205
Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu
    210                 215                 220
Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly
225                 230                 235                 240
Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu
                245                 250                 255
Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu
            260                 265                 270
Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His
        275                 280                 285
His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu
    290                 295                 300
His Glu Trp Val Leu Arg Glu Gly Glu Glu
305                 310

<210> 1122
<211> 315
<212> PRT
<213> Homo sapiens

<400> 1122
Met Ser Leu Glu Gln Arg Ser Pro His Cys Lys Pro Asp Glu Asp Leu
 1               5                  10                  15
Glu Ala Gln Gly Glu Asp Leu Gly Leu Met Gly Ala Gln Glu Pro Thr
            20                  25                  30
Gly Glu Glu Glu Glu Thr Thr Ser Ser Ser Asp Ser Lys Glu Glu Glu
        35                  40                  45
Val Ser Ala Ala Gly Ser Ser Ser Pro Pro Gln Ser Pro Gln Gly Gly
    50                  55                  60
Ala Ser Ser Ser Ile Ser Val Tyr Tyr Thr Leu Trp Ser Gln Phe Asp
65                  70                  75                  80
Glu Gly Ser Ser Ser Gln Glu Glu Glu Glu Pro Ser Ser Ser Val Asp
                85                  90                  95
Pro Ala Gln Leu Glu Phe Met Phe Gln Glu Ala Leu Lys Leu Lys Val
            100                 105                 110
Ala Glu Leu Val His Phe Leu Leu His Lys Tyr Arg Val Lys Glu Pro
        115                 120                 125
Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys Asn Tyr Lys Arg
    130                 135                 140
Tyr Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Phe Met Gln Val Ile
145                 150                 155                 160
Phe Gly Thr Asp Val Lys Glu Val Asp Pro Ala Gly His Ser Tyr Ile
                165                 170                 175
Leu Val Thr Ala Leu Gly Leu Ser Cys Asp Ser Met Leu Gly Asp Gly
            180                 185                 190
His Ser Met Pro Lys Ala Ala Leu Leu Ile Ile Val Leu Gly Val Ile
        195                 200                 205
Leu Thr Lys Asp Asn Cys Ala Pro Glu Glu Val Ile Trp Glu Ala Leu
    210                 215                 220
Ser Val Met Gly Val Tyr Val Gly Lys Glu His Met Phe Tyr Gly Glu
225                 230                 235                 240
Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu
                245                 250                 255
Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala His Tyr Glu Phe Leu Trp
            260                 265                 270
Gly Ser Lys Ala His Ala Glu Thr Ser Tyr Glu Lys Val Ile Asn Tyr
        275                 280                 285
Leu Val Met Leu Asn Ala Arg Glu Pro Ile Cys Tyr Pro Ser Leu Tyr
    290                 295                 300
Glu Glu Val Leu Gly Glu Glu Gln Glu Gly Val
305                 310                 315

<210> 1123
<211> 390
<212> PRT
<213> Homo sapiens

<400> 1123
Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg
 1               5                  10                  15
Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe
            20                  25                  30
Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro
        35                  40                  45
Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu
    50                  55                  60
Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys
65                  70                  75                  80
Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu
                85                  90                  95
Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr
            100                 105                 110
Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile
        115                 120                 125
Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu
    130                 135                 140
Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn
145                 150                 155                 160
Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu
                165                 170                 175
Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His
            180                 185                 190
Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala
        195                 200                 205
Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile
    210                 215                 220
Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu
225                 230                 235                 240
Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn
                245                 250                 255
Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu
            260                 265                 270
Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr
        275                 280                 285
Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu
    290                 295                 300
Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile
305                 310                 315                 320
Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala
                325                 330                 335
Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr
            340                 345                 350
Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu
        355                 360                 365
Glu Glu Glu Glu Asn Thr Glu Glu Pro Pro Gln Gly Glu Glu Glu Glu
    370                 375                 380
Ser Met Glu Thr Gln Glu
385                 390

<210> 1124
<211> 406
<212> PRT
<213> Homo sapiens

<400> 1124
Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg
 1               5                  10                  15
Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe
            20                  25                  30
Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro
        35                  40                  45
Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu
    50                  55                  60
Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys
65                  70                  75                  80
Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu
                85                  90                  95
Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr
            100                 105                 110
Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile
        115                 120                 125
Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu
    130                 135                 140
Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn
145                 150                 155                 160
Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu
                165                 170                 175
Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His
            180                 185                 190
Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala
        195                 200                 205
Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile
    210                 215                 220
Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu
225                 230                 235                 240
Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn
                245                 250                 255
Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu
            260                 265                 270
Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr
        275                 280                 285
Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu
    290                 295                 300
Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile
305                 310                 315                 320
Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala
                325                 330                 335
Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr
            340                 345                 350
Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu
        355                 360                 365
Glu Glu Glu Glu Asn Thr Glu Arg Thr Thr Ser Arg Arg Gly Arg Arg
    370                 375                 380
Lys His Gly Asn Ser Gly Val Thr Phe Pro Ser Leu Leu Phe Leu Pro
385                 390                 395                 400
Lys Gly Lys Thr Gly Ala
                405

<210> 1125
<211> 392
<212> PRT
<213> Homo sapiens

<400> 1125
Gly Ala Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly
 1               5                  10                  15
Ser Arg Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile
            20                  25                  30
Pro Phe Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro
        35                  40                  45
Ala Pro Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln
    50                  55                  60
Asp Leu Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val
65                  70                  75                  80
Thr Lys Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr
                85                  90                  95
Phe Glu Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys
            100                 105                 110
Gly Thr Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu
        115                 120                 125
Lys Ile Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val
    130                 135                 140
Val Glu Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu
145                 150                 155                 160
Thr Asn Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys
                165                 170                 175
Ile Leu Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu
            180                 185                 190
Leu His Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg
        195                 200                 205
His Ala Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val
    210                 215                 220
Leu Ile Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu
225                 230                 235                 240
Pro Leu Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met
                245                 250                 255
Asn Asn Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg
            260                 265                 270
Cys Leu Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly
        275                 280                 285
Ile Thr Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met
    290                 295                 300
Thr Leu Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val
305                 310                 315                 320
Arg Ile Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly
                325                 330                 335
Asp Ala Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile
            340                 345                 350
Val Thr Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu
        355                 360                 365
Gly Glu Glu Glu Glu Glu Asn Thr Glu Glu Pro Pro Gln Gly Glu Glu
    370                 375                 380
Glu Glu Ser Met Glu Thr Gln Glu
385                 390

<210> 1126
<211> 406
<212> PRT
<213> Homo sapiens

<400> 1126
Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg
 1               5                  10                  15
Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe
            20                  25                  30
Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro
        35                  40                  45
Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu
    50                  55                  60
Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys
65                  70                  75                  80
Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu
                85                  90                  95
Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr
            100                 105                 110
Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile
        115                 120                 125
Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu
    130                 135                 140
Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn
145                 150                 155                 160
Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu
                165                 170                 175
Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His
            180                 185                 190
Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala
        195                 200                 205
Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile
    210                 215                 220
Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu
225                 230                 235                 240
Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn
                245                 250                 255
Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu
            260                 265                 270
Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr
        275                 280                 285
Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu
    290                 295                 300
Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile
305                 310                 315                 320
Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala
                325                 330                 335
Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr
            340                 345                 350
Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu
        355                 360                 365
Glu Glu Glu Glu Asn Thr Glu Arg Thr Thr Ser Arg Arg Gly Arg Arg
    370                 375                 380
Lys His Gly Asn Ser Gly Val Thr Phe Pro Ser Leu Leu Phe Leu Pro
385                 390                 395                 400
Lys Gly Lys Thr Gly Ala
                405

<210> 1127
<211> 406
<212> PRT
<213> Homo sapiens

<400> 1127
Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg
 1               5                  10                  15
Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe
            20                  25                  30
Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro
        35                  40                  45
Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu
    50                  55                  60
Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys
65                  70                  75                  80
Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu
                85                  90                  95
Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr
            100                 105                 110
Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile
        115                 120                 125
Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu
    130                 135                 140
Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn
145                 150                 155                 160
Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu
                165                 170                 175
Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His
            180                 185                 190
Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala
        195                 200                 205
Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile
    210                 215                 220
Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu
225                 230                 235                 240
Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn
                245                 250                 255
Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu
            260                 265                 270
Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr
        275                 280                 285
Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu
    290                 295                 300
Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile
305                 310                 315                 320
Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala
                325                 330                 335
Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr
            340                 345                 350
Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu
        355                 360                 365
Glu Glu Glu Glu Asn Thr Glu Arg Thr Thr Ser Arg Arg Gly Arg Arg
    370                 375                 380
Lys His Gly Asn Ser Gly Val Thr Phe Pro Ser Leu Leu Phe Leu Pro
385                 390                 395                 400
Lys Gly Lys Thr Gly Ala
                405

<210> 1128
<211> 390
<212> PRT
<213> Homo sapiens

<400> 1128
Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg
 1               5                  10                  15
Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe
            20                  25                  30
Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro
        35                  40                  45
Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu
    50                  55                  60
Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys
65                  70                  75                  80
Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu
                85                  90                  95
Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr
            100                 105                 110
Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile
        115                 120                 125
Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu
    130                 135                 140
Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn
145                 150                 155                 160
Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu
                165                 170                 175
Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His
            180                 185                 190
Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala
        195                 200                 205
Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile
    210                 215                 220
Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu
225                 230                 235                 240
Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn
                245                 250                 255
Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu
            260                 265                 270
Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr
        275                 280                 285
Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu
    290                 295                 300
Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile
305                 310                 315                 320
Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala
                325                 330                 335
Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr
            340                 345                 350
Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu
        355                 360                 365
Glu Glu Glu Glu Asn Thr Glu Glu Pro Pro Gln Gly Glu Glu Glu Glu
    370                 375                 380
Ser Met Glu Thr Gln Glu
385                 390

<210> 1129
<211> 1225
<212> PRT
<213> Homo sapiens

<400> 1129
Ile Glu Asn Phe Lys Ser Tyr Lys Gly Arg Gln Ile Ile Gly Pro Phe
 1               5                  10                  15
Gln Arg Phe Thr Ala Ile Ile Gly Pro Asn Gly Ser Gly Lys Ser Asn
            20                  25                  30
Leu Met Asp Ala Ile Ser Phe Val Leu Gly Glu Lys Thr Ser Asn Leu
        35                  40                  45
Arg Val Lys Thr Leu Arg Asp Leu Ile His Gly Ala Pro Val Gly Lys
    50                  55                  60
Pro Ala Ala Asn Arg Ala Phe Val Ser Met Val Tyr Ser Glu Glu Gly
65                  70                  75                  80
Ala Glu Asp Arg Thr Phe Ala Arg Val Ile Val Gly Gly Ser Ser Glu
                85                  90                  95
Tyr Lys Ile Asn Asn Lys Val Val Gln Leu His Glu Tyr Ser Glu Glu
            100                 105                 110
Leu Glu Lys Leu Gly Ile Leu Ile Lys Ala Arg Asn Phe Leu Val Phe
        115                 120                 125
Gln Gly Ala Val Glu Ser Ile Ala Met Lys Asn Pro Lys Glu Arg Thr
    130                 135                 140
Ala Leu Phe Glu Glu Ile Ser Arg Ser Gly Glu Leu Ala Gln Glu Tyr
145                 150                 155                 160
Asp Lys Arg Lys Lys Glu Met Val Lys Ala Glu Glu Asp Thr Gln Phe
                165                 170                 175
Asn Tyr His Arg Lys Lys Asn Ile Ala Ala Glu Arg Lys Glu Ala Lys
            180                 185                 190
Gln Glu Lys Glu Glu Ala Asp Arg Tyr Gln Arg Leu Lys Asp Glu Val
        195                 200                 205
Val Arg Ala Gln Val Gln Leu Gln Leu Phe Lys Leu Tyr His Asn Glu
    210                 215                 220
Val Glu Ile Glu Lys Leu Asn Lys Glu Leu Ala Ser Lys Asn Lys Glu
225                 230                 235                 240
Ile Glu Lys Asp Lys Lys Arg Met Asp Lys Val Glu Asp Glu Leu Lys
                245                 250                 255
Glu Lys Lys Lys Glu Leu Gly Lys Met Met Arg Glu Gln Gln Gln Ile
            260                 265                 270
Glu Lys Glu Ile Lys Glu Lys Asp Ser Glu Leu Asn Gln Lys Arg Pro
        275                 280                 285
Gln Tyr Ile Lys Ala Lys Glu Asn Thr Ser His Lys Ile Lys Lys Leu
    290                 295                 300
Glu Ala Ala Lys Lys Ser Leu Gln Asn Ala Gln Lys His Tyr Lys Lys
305                 310                 315                 320
Arg Lys Gly Asp Met Asp Glu Leu Glu Lys Glu Met Leu Ser Val Glu
                325                 330                 335
Lys Ala Arg Gln Glu Phe Glu Glu Arg Met Glu Glu Glu Ser Gln Ser
            340                 345                 350
Gln Gly Arg Asp Leu Thr Leu Glu Glu Asn Gln Val Lys Lys Tyr His
        355                 360                 365
Arg Leu Lys Glu Glu Ala Ser Lys Arg Ala Ala Thr Leu Ala Gln Glu
    370                 375                 380
Leu Glu Lys Phe Asn Arg Asp Gln Lys Ala Asp Gln Asp Arg Leu Asp
385                 390                 395                 400
Leu Glu Glu Arg Lys Lys Val Glu Thr Glu Ala Lys Ile Lys Gln Lys
                405                 410                 415
Leu Arg Glu Ile Glu Glu Asn Gln Lys Arg Ile Glu Lys Leu Glu Glu
            420                 425                 430
Tyr Ile Thr Thr Ser Lys Gln Ser Leu Glu Glu Gln Lys Lys Leu Glu
        435                 440                 445
Gly Glu Leu Thr Glu Glu Val Glu Met Ala Lys Arg Arg Ile Asp Glu
    450                 455                 460
Ile Asn Lys Glu Leu Asn Gln Val Met Glu Gln Leu Gly Asp Ala Arg
465                 470                 475                 480
Ile Asp Arg Gln Glu Ser Ser Arg Gln Gln Arg Lys Ala Glu Ile Met
                485                 490                 495
Glu Ser Ile Lys Arg Leu Tyr Pro Gly Ser Val Tyr Gly Arg Leu Ile
            500                 505                 510
Asp Leu Cys Gln Pro Thr Gln Lys Lys Tyr Gln Ile Ala Val Thr Lys
        515                 520                 525
Val Leu Gly Lys Asn Met Asp Ala Ile Ile Val Asp Ser Glu Lys Thr
    530                 535                 540
Gly Arg Asp Cys Ile Gln Tyr Ile Lys Glu Gln Arg Gly Glu Pro Glu
545                 550                 555                 560
Thr Phe Leu Pro Leu Asp Tyr Leu Glu Val Lys Pro Thr Asp Glu Lys
                565                 570                 575
Leu Arg Glu Leu Lys Gly Ala Lys Leu Val Ile Asp Val Ile Arg Tyr
            580                 585                 590
Glu Pro Pro His Ile Lys Lys Ala Leu Gln Tyr Ala Cys Gly Asn Ala
        595                 600                 605
Leu Val Cys Asp Asn Val Glu Asp Ala Arg Arg Ile Ala Phe Gly Gly
    610                 615                 620
His Gln Arg His Lys Thr Val Ala Leu Asp Gly Thr Leu Phe Gln Lys
625                 630                 635                 640
Ser Gly Val Ile Ser Gly Gly Ala Ser Asp Leu Lys Ala Lys Ala Arg
                645                 650                 655
Arg Trp Asp Glu Lys Ala Val Asp Lys Leu Lys Glu Lys Lys Glu Arg
            660                 665                 670
Leu Thr Glu Glu Leu Lys Glu Gln Met Lys Ala Lys Arg Lys Glu Ala
        675                 680                 685
Glu Leu Arg Gln Val Gln Ser Gln Ala His Gly Leu Gln Met Arg Leu
    690                 695                 700
Lys Tyr Ser Gln Ser Asp Leu Glu Gln Thr Lys Thr Arg His Leu Ala
705                 710                 715                 720
Leu Asn Leu Gln Glu Lys Ser Lys Leu Glu Ser Glu Leu Ala Asn Phe
                725                 730                 735
Gly Pro Arg Ile Asn Asp Ile Lys Arg Ile Ile Gln Ser Arg Glu Arg
            740                 745                 750
Glu Met Lys Asp Leu Lys Glu Lys Met Asn Gln Val Glu Asp Glu Val
        755                 760                 765
Phe Glu Glu Phe Cys Arg Glu Ile Gly Val Arg Asn Ile Arg Glu Phe
    770                 775                 780
Glu Glu Glu Lys Val Lys Arg Gln Asn Glu Ile Ala Lys Lys Arg Leu
785                 790                 795                 800
Glu Phe Glu Asn Gln Lys Thr Arg Leu Gly Ile Gln Leu Asp Phe Glu
                805                 810                 815
Lys Asn Gln Leu Lys Glu Asp Gln Asp Lys Val His Met Trp Glu Gln
            820                 825                 830
Thr Val Lys Lys Asp Glu Asn Glu Ile Glu Lys Leu Lys Lys Glu Glu
        835                 840                 845
Gln Arg His Met Lys Ile Ile Asp Glu Thr Met Ala Gln Leu Gln Asp
    850                 855                 860
Leu Lys Asn Gln His Leu Ala Lys Lys Ser Glu Val Asn Asp Lys Asn
865                 870                 875                 880
His Glu Met Glu Glu Ile Arg Lys Lys Leu Gly Gly Ala Asn Lys Glu
                885                 890                 895
Met Thr His Leu Gln Lys Glu Val Thr Ala Ile Glu Thr Lys Leu Glu
            900                 905                 910
Gln Lys Arg Ser Asp Arg His Asn Leu Leu Gln Ala Cys Lys Met Gln
        915                 920                 925
Asp Ile Lys Leu Pro Leu Ser Lys Gly Thr Met Asp Asp Ile Ser Gln
    930                 935                 940
Glu Glu Gly Ser Ser Gln Gly Glu Asp Ser Val Ser Gly Ser Gln Arg
945                 950                 955                 960
Ile Ser Ser Ile Tyr Ala Arg Glu Ala Leu Ile Glu Ile Asp Tyr Gly
                965                 970                 975
Asp Leu Cys Glu Asp Leu Lys Asp Ala Gln Ala Glu Glu Glu Ile Lys
            980                 985                 990
Gln Glu Met Asn Thr Leu Gln Gln Lys Leu Asn Glu Gln Gln Ser Val
        995                 1000                1005
Leu Gln Arg Ile Ala Ala Pro Asn Met Lys Ala Met Glu Lys Leu Glu
    1010                1015                1020
Ser Val Arg Asp Lys Phe Gln Glu Thr Ser Asp Glu Phe Glu Ala Ala
1025                1030                1035                1040
Arg Lys Arg Ala Lys Lys Ala Lys Gln Ala Phe Glu Gln Ile Lys Lys
                1045                1050                1055
Glu Arg Phe Asp Arg Phe Asn Ala Cys Phe Glu Ser Val Ala Thr Asn
            1060                1065                1070
Ile Asp Glu Ile Tyr Lys Ala Leu Ser Arg Asn Ser Ser Ala Gln Ala
        1075                1080                1085
Phe Leu Gly Pro Glu Asn Pro Glu Glu Pro Tyr Leu Asp Gly Ile Asn
    1090                1095                1100
Tyr Asn Cys Val Ala Pro Gly Lys Arg Phe Arg Pro Met Asp Asn Leu
1105                1110                1115                1120
Ser Gly Gly Glu Lys Thr Val Ala Ala Leu Ala Leu Leu Phe Ala Ile
                1125                1130                1135
His Ser Tyr Lys Pro Ala Pro Phe Phe Val Leu Asp Glu Ile Asp Ala
            1140                1145                1150
Ala Leu Asp Asn Thr Asn Ile Gly Lys Val Ala Asn Tyr Ile Lys Glu
        1155                1160                1165
Gln Ser Thr Cys Asn Phe Gln Ala Ile Val Ile Ser Leu Lys Glu Glu
    1170                1175                1180
Phe Tyr Thr Lys Ala Glu Ser Leu Ile Gly Val Tyr Pro Glu Gln Gly
1185                1190                1195                1200
Asp Cys Val Ile Ser Lys Val Leu Thr Phe Asp Leu Thr Lys Tyr Pro
                1205                1210                1215
Asp Ala Asn Pro Asn Pro Asn Glu Gln
            1220                1225

<210> 1130
<211> 1233
<212> PRT
<213> Homo sapiens

<400> 1130
Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys
 1               5                  10                  15
Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly
            20                  25                  30
Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val
        35                  40                  45
Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu
    50                  55                  60
Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val
65                  70                  75                  80
Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg
                85                  90                  95
Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val
            100                 105                 110
Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile
        115                 120                 125
Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala
    130                 135                 140
Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg
145                 150                 155                 160
Ser Gly Asp Val Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val
                165                 170                 175
Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile
            180                 185                 190
Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg
        195                 200                 205
Tyr Gln Arg Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln
    210                 215                 220
Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys
225                 230                 235                 240
Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met
                245                 250                 255
Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys
            260                 265                 270
Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp
        275                 280                 285
Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn
    290                 295                 300
Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln
305                 310                 315                 320
Asn Ala Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu
                325                 330                 335
Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu
            340                 345                 350
Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu
        355                 360                 365
Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys
    370                 375                 380
Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln
385                 390                 395                 400
Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu
                405                 410                 415
Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln
            420                 425                 430
Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser
        435                 440                 445
Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu
    450                 455                 460
Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val
465                 470                 475                 480
Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg
                485                 490                 495
Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro
            500                 505                 510
Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys
        515                 520                 525
Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala
    530                 535                 540
Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile
545                 550                 555                 560
Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu
                565                 570                 575
Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys
            580                 585                 590
Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala
        595                 600                 605
Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp
    610                 615                 620
Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala
625                 630                 635                 640
Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala
                645                 650                 655
Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp
            660                 665                 670
Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln
        675                 680                 685
Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln
    690                 695                 700
Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu
705                 710                 715                 720
Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys
                725                 730                 735
Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys
            740                 745                 750
Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys
        755                 760                 765
Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile
    770                 775                 780
Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln
785                 790                 795                 800
Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg
                805                 810                 815
Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln
            820                 825                 830
Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu
        835                 840                 845
Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp
    850                 855                 860
Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys
865                 870                 875                 880
Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys
                885                 890                 895
Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val
            900                 905                 910
Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn
        915                 920                 925
Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys
    930                 935                 940
Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Ser Ser Gln Gly Glu
945                 950                 955                 960
Asp Ser Val Ser Gly Ser Gln Arg Ile Ser Ser Ile Tyr Ala Arg Glu
                965                 970                 975
Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp
            980                 985                 990
Ala Gln Ala Glu Glu Glu Ile Lys Gln Glu Met Asn Thr Leu Gln Gln
        995                 1000                1005
Lys Leu Asn Glu Gln Gln Ser Val Leu Gln Arg Ile Ala Ala Pro Asn
    1010                1015                1020
Met Lys Ala Met Glu Lys Leu Glu Ser Val Arg Asp Lys Phe Gln Glu
1025                1030                1035                1040
Thr Ser Asp Glu Phe Glu Ala Ala Arg Lys Arg Ala Lys Lys Ala Lys
                1045                1050                1055
Gln Ala Phe Glu Gln Ile Lys Lys Glu Arg Phe Asp Arg Phe Asn Ala
            1060                1065                1070
Cys Phe Glu Ser Val Ala Thr Asn Ile Asp Glu Ile Tyr Lys Ala Leu
        1075                1080                1085
Ser Arg Asn Ser Ser Ala Gln Ala Phe Leu Gly Pro Glu Asn Pro Glu
    1090                1095                1100
Glu Pro Tyr Leu Asp Gly Ile Asn Tyr Asn Cys Val Ala Pro Gly Lys
1105                1110                1115                1120
Arg Phe Arg Pro Met Asp Asn Leu Ser Gly Gly Glu Lys Thr Val Ala
                1125                1130                1135
Ala Leu Ala Leu Leu Phe Ala Ile His Ser Tyr Lys Pro Ala Pro Phe
            1140                1145                1150
Phe Val Leu Asp Glu Ile Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly
        1155                1160                1165
Lys Val Ala Asn Tyr Ile Lys Glu Gln Ser Thr Cys Asn Phe Gln Ala
    1170                1175                1180
Ile Val Ile Ser Leu Lys Glu Glu Phe Tyr Thr Lys Ala Glu Ser Leu
1185                1190                1195                1200
Ile Gly Val Tyr Pro Glu Gln Gly Asp Cys Val Ile Ser Lys Val Leu
                1205                1210                1215
Thr Phe Asp Leu Thr Lys Tyr Pro Asp Ala Asn Pro Asn Pro Asn Glu
            1220                1225                1230
Gln


<210> 1131
<211> 1233
<212> PRT
<213> Homo sapiens

<400> 1131
Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys
 1               5                  10                  15
Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly
            20                  25                  30
Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val
        35                  40                  45
Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu
    50                  55                  60
Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val
65                  70                  75                  80
Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg
                85                  90                  95
Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val
            100                 105                 110
Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile
        115                 120                 125
Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala
    130                 135                 140
Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg
145                 150                 155                 160
Ser Gly Asp Val Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val
                165                 170                 175
Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile
            180                 185                 190
Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg
        195                 200                 205
Tyr Gln Arg Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln
    210                 215                 220
Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys
225                 230                 235                 240
Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met
                245                 250                 255
Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys
            260                 265                 270
Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp
        275                 280                 285
Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn
    290                 295                 300
Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln
305                 310                 315                 320
Asn Ala Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu
                325                 330                 335
Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu
            340                 345                 350
Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu
        355                 360                 365
Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys
    370                 375                 380
Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln
385                 390                 395                 400
Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu
                405                 410                 415
Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln
            420                 425                 430
Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser
        435                 440                 445
Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu
    450                 455                 460
Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val
465                 470                 475                 480
Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg
                485                 490                 495
Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro
            500                 505                 510
Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys
        515                 520                 525
Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala
    530                 535                 540
Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile
545                 550                 555                 560
Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu
                565                 570                 575
Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys
            580                 585                 590
Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala
        595                 600                 605
Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp
    610                 615                 620
Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala
625                 630                 635                 640
Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala
                645                 650                 655
Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp
            660                 665                 670
Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln
        675                 680                 685
Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln
    690                 695                 700
Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu
705                 710                 715                 720
Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys
                725                 730                 735
Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys
            740                 745                 750
Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys
        755                 760                 765
Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile
    770                 775                 780
Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln
785                 790                 795                 800
Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg
                805                 810                 815
Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln
            820                 825                 830
Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu
        835                 840                 845
Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp
    850                 855                 860
Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys
865                 870                 875                 880
Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys
                885                 890                 895
Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val
            900                 905                 910
Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn
        915                 920                 925
Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys
    930                 935                 940
Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Ser Ser Gln Gly Glu
945                 950                 955                 960
Asp Ser Val Ser Gly Ser Gln Arg Ile Ser Ser Ile Tyr Ala Arg Glu
                965                 970                 975
Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp
            980                 985                 990
Ala Gln Ala Glu Glu Glu Ile Lys Gln Glu Met Asn Thr Leu Gln Gln
        995                 1000                1005
Lys Leu Asn Glu Gln Gln Ser Val Leu Gln Arg Ile Ala Ala Pro Asn
    1010                1015                1020
Met Lys Ala Met Glu Lys Leu Glu Ser Val Arg Asp Lys Phe Gln Glu
1025                1030                1035                1040
Thr Ser Asp Glu Phe Glu Ala Ala Arg Lys Arg Ala Lys Lys Ala Lys
                1045                1050                1055
Gln Ala Phe Glu Gln Ile Lys Lys Glu Arg Phe Asp Arg Phe Asn Ala
            1060                1065                1070
Cys Phe Glu Ser Val Ala Thr Asn Ile Asp Glu Ile Tyr Lys Ala Leu
        1075                1080                1085
Ser Arg Asn Ser Ser Ala Gln Ala Phe Leu Gly Pro Glu Asn Pro Glu
    1090                1095                1100
Glu Pro Tyr Leu Asp Gly Ile Asn Tyr Asn Cys Val Ala Pro Gly Lys
1105                1110                1115                1120
Arg Phe Arg Pro Met Asp Asn Leu Ser Gly Gly Glu Lys Thr Val Ala
                1125                1130                1135
Ala Leu Ala Leu Leu Phe Ala Ile His Ser Tyr Lys Pro Ala Pro Phe
            1140                1145                1150
Phe Val Leu Asp Glu Ile Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly
        1155                1160                1165
Lys Val Ala Asn Tyr Ile Lys Glu Gln Ser Thr Cys Asn Phe Gln Ala
    1170                1175                1180
Ile Val Ile Ser Leu Lys Glu Glu Phe Tyr Thr Lys Ala Glu Ser Leu
1185                1190                1195                1200
Ile Gly Val Tyr Pro Glu Gln Gly Asp Cys Val Ile Ser Lys Val Leu
                1205                1210                1215
Thr Phe Asp Leu Thr Lys Tyr Pro Asp Ala Asn Pro Asn Pro Asn Glu
            1220                1225                1230
Gln


<210> 1132
<211> 1225
<212> PRT
<213> Homo sapiens

<400> 1132
Ile Glu Asn Phe Lys Ser Tyr Lys Gly Arg Gln Ile Ile Gly Pro Phe
 1               5                  10                  15
Gln Arg Phe Thr Ala Ile Ile Gly Pro Asn Gly Ser Gly Lys Ser Asn
            20                  25                  30
Leu Met Asp Ala Ile Ser Phe Val Leu Gly Glu Lys Thr Ser Asn Leu
        35                  40                  45
Arg Val Lys Thr Leu Arg Asp Leu Ile His Gly Ala Pro Val Gly Lys
    50                  55                  60
Pro Ala Ala Asn Arg Ala Phe Val Ser Met Val Tyr Ser Glu Glu Gly
65                  70                  75                  80
Ala Glu Asp Arg Thr Phe Ala Arg Val Ile Val Gly Gly Ser Ser Glu
                85                  90                  95
Tyr Lys Ile Asn Asn Lys Val Val Gln Leu His Glu Tyr Ser Glu Glu
            100                 105                 110
Leu Glu Lys Leu Gly Ile Leu Ile Lys Ala Arg Asn Phe Leu Val Phe
        115                 120                 125
Gln Gly Ala Val Glu Ser Ile Ala Met Lys Asn Pro Lys Glu Arg Thr
    130                 135                 140
Ala Leu Phe Glu Glu Ile Ser Arg Ser Gly Glu Leu Ala Gln Glu Tyr
145                 150                 155                 160
Asp Lys Arg Lys Lys Glu Met Val Lys Ala Glu Glu Asp Thr Gln Phe
                165                 170                 175
Asn Tyr His Arg Lys Lys Asn Ile Ala Ala Glu Arg Lys Glu Ala Lys
            180                 185                 190
Gln Glu Lys Glu Glu Ala Asp Arg Tyr Gln Arg Leu Lys Asp Glu Val
        195                 200                 205
Val Arg Ala Gln Val Gln Leu Gln Leu Phe Lys Leu Tyr His Asn Glu
    210                 215                 220
Val Glu Ile Glu Lys Leu Asn Lys Glu Leu Ala Ser Lys Asn Lys Glu
225                 230                 235                 240
Ile Glu Lys Asp Lys Lys Arg Met Asp Lys Val Glu Asp Glu Leu Lys
                245                 250                 255
Glu Lys Lys Lys Glu Leu Gly Lys Met Met Arg Glu Gln Gln Gln Ile
            260                 265                 270
Glu Lys Glu Ile Lys Glu Lys Asp Ser Glu Leu Asn Gln Lys Arg Pro
        275                 280                 285
Gln Tyr Ile Lys Ala Lys Glu Asn Thr Ser His Lys Ile Lys Lys Leu
    290                 295                 300
Glu Ala Ala Lys Lys Ser Leu Gln Asn Ala Gln Lys His Tyr Lys Lys
305                 310                 315                 320
Arg Lys Gly Asp Met Asp Glu Leu Glu Lys Glu Met Leu Ser Val Glu
                325                 330                 335
Lys Ala Arg Gln Glu Phe Glu Glu Arg Met Glu Glu Glu Ser Gln Ser
            340                 345                 350
Gln Gly Arg Asp Leu Thr Leu Glu Glu Asn Gln Val Lys Lys Tyr His
        355                 360                 365
Arg Leu Lys Glu Glu Ala Ser Lys Arg Ala Ala Thr Leu Ala Gln Glu
    370                 375                 380
Leu Glu Lys Phe Asn Arg Asp Gln Lys Ala Asp Gln Asp Arg Leu Asp
385                 390                 395                 400
Leu Glu Glu Arg Lys Lys Val Glu Thr Glu Ala Lys Ile Lys Gln Lys
                405                 410                 415
Leu Arg Glu Ile Glu Glu Asn Gln Lys Arg Ile Glu Lys Leu Glu Glu
            420                 425                 430
Tyr Ile Thr Thr Ser Lys Gln Ser Leu Glu Glu Gln Lys Lys Leu Glu
        435                 440                 445
Gly Glu Leu Thr Glu Glu Val Glu Met Ala Lys Arg Arg Ile Asp Glu
    450                 455                 460
Ile Asn Lys Glu Leu Asn Gln Val Met Glu Gln Leu Gly Asp Ala Arg
465                 470                 475                 480
Ile Asp Arg Gln Glu Ser Ser Arg Gln Gln Arg Lys Ala Glu Ile Met
                485                 490                 495
Glu Ser Ile Lys Arg Leu Tyr Pro Gly Ser Val Tyr Gly Arg Leu Ile
            500                 505                 510
Asp Leu Cys Gln Pro Thr Gln Lys Lys Tyr Gln Ile Ala Val Thr Lys
        515                 520                 525
Val Leu Gly Lys Asn Met Asp Ala Ile Ile Val Asp Ser Glu Lys Thr
    530                 535                 540
Gly Arg Asp Cys Ile Gln Tyr Ile Lys Glu Gln Arg Gly Glu Pro Glu
545                 550                 555                 560
Thr Phe Leu Pro Leu Asp Tyr Leu Glu Val Lys Pro Thr Asp Glu Lys
                565                 570                 575
Leu Arg Glu Leu Lys Gly Ala Lys Leu Val Ile Asp Val Ile Arg Tyr
            580                 585                 590
Glu Pro Pro His Ile Lys Lys Ala Leu Gln Tyr Ala Cys Gly Asn Ala
        595                 600                 605
Leu Val Cys Asp Asn Val Glu Asp Ala Arg Arg Ile Ala Phe Gly Gly
    610                 615                 620
His Gln Arg His Lys Thr Val Ala Leu Asp Gly Thr Leu Phe Gln Lys
625                 630                 635                 640
Ser Gly Val Ile Ser Gly Gly Ala Ser Asp Leu Lys Ala Lys Ala Arg
                645                 650                 655
Arg Trp Asp Glu Lys Ala Val Asp Lys Leu Lys Glu Lys Lys Glu Arg
            660                 665                 670
Leu Thr Glu Glu Leu Lys Glu Gln Met Lys Ala Lys Arg Lys Glu Ala
        675                 680                 685
Glu Leu Arg Gln Val Gln Ser Gln Ala His Gly Leu Gln Met Arg Leu
    690                 695                 700
Lys Tyr Ser Gln Ser Asp Leu Glu Gln Thr Lys Thr Arg His Leu Ala
705                 710                 715                 720
Leu Asn Leu Gln Glu Lys Ser Lys Leu Glu Ser Glu Leu Ala Asn Phe
                725                 730                 735
Gly Pro Arg Ile Asn Asp Ile Lys Arg Ile Ile Gln Ser Arg Glu Arg
            740                 745                 750
Glu Met Lys Asp Leu Lys Glu Lys Met Asn Gln Val Glu Asp Glu Val
        755                 760                 765
Phe Glu Glu Phe Cys Arg Glu Ile Gly Val Arg Asn Ile Arg Glu Phe
    770                 775                 780
Glu Glu Glu Lys Val Lys Arg Gln Asn Glu Ile Ala Lys Lys Arg Leu
785                 790                 795                 800
Glu Phe Glu Asn Gln Lys Thr Arg Leu Gly Ile Gln Leu Asp Phe Glu
                805                 810                 815
Lys Asn Gln Leu Lys Glu Asp Gln Asp Lys Val His Met Trp Glu Gln
            820                 825                 830
Thr Val Lys Lys Asp Glu Asn Glu Ile Glu Lys Leu Lys Lys Glu Glu
        835                 840                 845
Gln Arg His Met Lys Ile Ile Asp Glu Thr Met Ala Gln Leu Gln Asp
    850                 855                 860
Leu Lys Asn Gln His Leu Ala Lys Lys Ser Glu Val Asn Asp Lys Asn
865                 870                 875                 880
His Glu Met Glu Glu Ile Arg Lys Lys Leu Gly Gly Ala Asn Lys Glu
                885                 890                 895
Met Thr His Leu Gln Lys Glu Val Thr Ala Ile Glu Thr Lys Leu Glu
            900                 905                 910
Gln Lys Arg Ser Asp Arg His Asn Leu Leu Gln Ala Cys Lys Met Gln
        915                 920                 925
Asp Ile Lys Leu Pro Leu Ser Lys Gly Thr Met Asp Asp Ile Ser Gln
    930                 935                 940
Glu Glu Gly Ser Ser Gln Gly Glu Asp Ser Val Ser Gly Ser Gln Arg
945                 950                 955                 960
Ile Ser Ser Ile Tyr Ala Arg Glu Ala Leu Ile Glu Ile Asp Tyr Gly
                965                 970                 975
Asp Leu Cys Glu Asp Leu Lys Asp Ala Gln Ala Glu Glu Glu Ile Lys
            980                 985                 990
Gln Glu Met Asn Thr Leu Gln Gln Lys Leu Asn Glu Gln Gln Ser Val
        995                 1000                1005
Leu Gln Arg Ile Ala Ala Pro Asn Met Lys Ala Met Glu Lys Leu Glu
    1010                1015                1020
Ser Val Arg Asp Lys Phe Gln Glu Thr Ser Asp Glu Phe Glu Ala Ala
1025                1030                1035                1040
Arg Lys Arg Ala Lys Lys Ala Lys Gln Ala Phe Glu Gln Ile Lys Lys
                1045                1050                1055
Glu Arg Phe Asp Arg Phe Asn Ala Cys Phe Glu Ser Val Ala Thr Asn
            1060                1065                1070
Ile Asp Glu Ile Tyr Lys Ala Leu Ser Arg Asn Ser Ser Ala Gln Ala
        1075                1080                1085
Phe Leu Gly Pro Glu Asn Pro Glu Glu Pro Tyr Leu Asp Gly Ile Asn
    1090                1095                1100
Tyr Asn Cys Val Ala Pro Gly Lys Arg Phe Arg Pro Met Asp Asn Leu
1105                1110                1115                1120
Ser Gly Gly Glu Lys Thr Val Ala Ala Leu Ala Leu Leu Phe Ala Ile
                1125                1130                1135
His Ser Tyr Lys Pro Ala Pro Phe Phe Val Leu Asp Glu Ile Asp Ala
            1140                1145                1150
Ala Leu Asp Asn Thr Asn Ile Gly Lys Val Ala Asn Tyr Ile Lys Glu
        1155                1160                1165
Gln Ser Thr Cys Asn Phe Gln Ala Ile Val Ile Ser Leu Lys Glu Glu
    1170                1175                1180
Phe Tyr Thr Lys Ala Glu Ser Leu Ile Gly Val Tyr Pro Glu Gln Gly
1185                1190                1195                1200
Asp Cys Val Ile Ser Lys Val Leu Thr Phe Asp Leu Thr Lys Tyr Pro
                1205                1210                1215
Asp Ala Asn Pro Asn Pro Asn Glu Gln
            1220                1225

<210> 1133
<211> 1233
<212> PRT
<213> Homo sapiens

<400> 1133
Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys
 1               5                  10                  15
Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly
            20                  25                  30
Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val
        35                  40                  45
Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu
    50                  55                  60
Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val
65                  70                  75                  80
Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg
                85                  90                  95
Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val
            100                 105                 110
Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile
        115                 120                 125
Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala
    130                 135                 140
Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg
145                 150                 155                 160
Ser Gly Asp Val Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val
                165                 170                 175
Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile
            180                 185                 190
Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg
        195                 200                 205
Tyr Gln Arg Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln
    210                 215                 220
Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys
225                 230                 235                 240
Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met
                245                 250                 255
Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys
            260                 265                 270
Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp
        275                 280                 285
Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn
    290                 295                 300
Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln
305                 310                 315                 320
Asn Ala Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu
                325                 330                 335
Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu
            340                 345                 350
Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu
        355                 360                 365
Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys
    370                 375                 380
Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln
385                 390                 395                 400
Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu
                405                 410                 415
Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln
            420                 425                 430
Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser
        435                 440                 445
Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu
    450                 455                 460
Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val
465                 470                 475                 480
Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg
                485                 490                 495
Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro
            500                 505                 510
Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys
        515                 520                 525
Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala
    530                 535                 540
Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile
545                 550                 555                 560
Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu
                565                 570                 575
Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys
            580                 585                 590
Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala
        595                 600                 605
Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp
    610                 615                 620
Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala
625                 630                 635                 640
Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala
                645                 650                 655
Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp
            660                 665                 670
Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln
        675                 680                 685
Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln
    690                 695                 700
Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu
705                 710                 715                 720
Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys
                725                 730                 735
Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys
            740                 745                 750
Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys
        755                 760                 765
Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile
    770                 775                 780
Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln
785                 790                 795                 800
Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg
                805                 810                 815
Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln
            820                 825                 830
Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu
        835                 840                 845
Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp
    850                 855                 860
Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys
865                 870                 875                 880
Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys
                885                 890                 895
Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val
            900                 905                 910
Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn
        915                 920                 925
Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys
    930                 935                 940
Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Ser Ser Gln Gly Glu
945                 950                 955                 960
Asp Ser Val Ser Gly Ser Gln Arg Ile Ser Ser Ile Tyr Ala Arg Glu
                965                 970                 975
Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp
            980                 985                 990
Ala Gln Ala Glu Glu Glu Ile Lys Gln Glu Met Asn Thr Leu Gln Gln
        995                 1000                1005
Lys Leu Asn Glu Gln Gln Ser Val Leu Gln Arg Ile Ala Ala Pro Asn
    1010                1015                1020
Met Lys Ala Met Glu Lys Leu Glu Ser Val Arg Asp Lys Phe Gln Glu
1025                1030                1035                1040
Thr Ser Asp Glu Phe Glu Ala Ala Arg Lys Arg Ala Lys Lys Ala Lys
                1045                1050                1055
Gln Ala Phe Glu Gln Ile Lys Lys Glu Arg Phe Asp Arg Phe Asn Ala
            1060                1065                1070
Cys Phe Glu Ser Val Ala Thr Asn Ile Asp Glu Ile Tyr Lys Ala Leu
        1075                1080                1085
Ser Arg Asn Ser Ser Ala Gln Ala Phe Leu Gly Pro Glu Asn Pro Glu
    1090                1095                1100
Glu Pro Tyr Leu Asp Gly Ile Asn Tyr Asn Cys Val Ala Pro Gly Lys
1105                1110                1115                1120
Arg Phe Arg Pro Met Asp Asn Leu Ser Gly Gly Glu Lys Thr Val Ala
                1125                1130                1135
Ala Leu Ala Leu Leu Phe Ala Ile His Ser Tyr Lys Pro Ala Pro Phe
            1140                1145                1150
Phe Val Leu Asp Glu Ile Asp Ala Ala Leu Asp Asn Thr Asn Ile Gly
        1155                1160                1165
Lys Val Ala Asn Tyr Ile Lys Glu Gln Ser Thr Cys Asn Phe Gln Ala
    1170                1175                1180
Ile Val Ile Ser Leu Lys Glu Glu Phe Tyr Thr Lys Ala Glu Ser Leu
1185                1190                1195                1200
Ile Gly Val Tyr Pro Glu Gln Gly Asp Cys Val Ile Ser Lys Val Leu
                1205                1210                1215
Thr Phe Asp Leu Thr Lys Tyr Pro Asp Ala Asn Pro Asn Pro Asn Glu
            1220                1225                1230
Gln


<210> 1134
<211> 858
<212> PRT
<213> Homo sapiens

<400> 1134
Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly
 1               5                  10                  15
Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe
            20                  25                  30
Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr
        35                  40                  45
Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser
    50                  55                  60
Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln
65                  70                  75                  80
Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn
                85                  90                  95
Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro
            100                 105                 110
Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe
        115                 120                 125
Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu
    130                 135                 140
Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu
145                 150                 155                 160
Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp
                165                 170                 175
Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro
            180                 185                 190
Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu
        195                 200                 205
Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg
    210                 215                 220
Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val
225                 230                 235                 240
Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe
                245                 250                 255
Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His
            260                 265                 270
Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser
        275                 280                 285
Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn
    290                 295                 300
Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala
305                 310                 315                 320
Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp
                325                 330                 335
Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr
            340                 345                 350
Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln
        355                 360                 365
Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu
    370                 375                 380
Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His
385                 390                 395                 400
Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val
                405                 410                 415
Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu
            420                 425                 430
Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro
        435                 440                 445
His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser
    450                 455                 460
Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu
465                 470                 475                 480
Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp
                485                 490                 495
Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn
            500                 505                 510
Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu
        515                 520                 525
Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn
    530                 535                 540
Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu
545                 550                 555                 560
Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile
                565                 570                 575
Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn
            580                 585                 590
Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile
        595                 600                 605
Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu
    610                 615                 620
Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe
625                 630                 635                 640
Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr
                645                 650                 655
Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys
            660                 665                 670
Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro
        675                 680                 685
Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe
    690                 695                 700
Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser
705                 710                 715                 720
Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro
                725                 730                 735
Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg
            740                 745                 750
Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys
        755                 760                 765
Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn
    770                 775                 780
Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu
785                 790                 795                 800
Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu
                805                 810                 815
Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu
            820                 825                 830
Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn
        835                 840                 845
Ile Pro Leu Gln Thr Val Ala Thr Ile Ser
    850                 855

<210> 1135
<211> 858
<212> PRT
<213> Homo sapiens

<400> 1135
Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly
 1               5                  10                  15
Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe
            20                  25                  30
Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr
        35                  40                  45
Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser
    50                  55                  60
Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln
65                  70                  75                  80
Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn
                85                  90                  95
Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro
            100                 105                 110
Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe
        115                 120                 125
Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu
    130                 135                 140
Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu
145                 150                 155                 160
Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp
                165                 170                 175
Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro
            180                 185                 190
Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu
        195                 200                 205
Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg
    210                 215                 220
Asn Met Val Leu Glu Ile Val Asp Val Ser Gly Asn Gly Trp Thr Val
225                 230                 235                 240
Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe
                245                 250                 255
Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His
            260                 265                 270
Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser
        275                 280                 285
Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn
    290                 295                 300
Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala
305                 310                 315                 320
Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp
                325                 330                 335
Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Cys
            340                 345                 350
Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln
        355                 360                 365
Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu
    370                 375                 380
Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His
385                 390                 395                 400
Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val
                405                 410                 415
Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu
            420                 425                 430
Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro
        435                 440                 445
His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser
    450                 455                 460
Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu
465                 470                 475                 480
Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp
                485                 490                 495
Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn
            500                 505                 510
Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu
        515                 520                 525
Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn
    530                 535                 540
Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu
545                 550                 555                 560
Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile
                565                 570                 575
Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn
            580                 585                 590
Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile
        595                 600                 605
Tyr Cys Val Tyr Pro Asp Ser Leu Ser Gly Val Ser Leu Phe Ser Leu
    610                 615                 620
Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe
625                 630                 635                 640
Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr
                645                 650                 655
Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys
            660                 665                 670
Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro
        675                 680                 685
Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe
    690                 695                 700
Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser
705                 710                 715                 720
Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro
                725                 730                 735
Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg
            740                 745                 750
Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys
        755                 760                 765
Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn
    770                 775                 780
Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu
785                 790                 795                 800
Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu
                805                 810                 815
Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu
            820                 825                 830
Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn
        835                 840                 845
Ile Pro Leu Gln Thr Val Ala Thr Ile Ser
    850                 855

<210> 1136
<211> 873
<212> PRT
<213> Homo sapiens

<400> 1136
Asn Lys Asn Ile Leu Glu Val Pro Ser Ala Arg Thr Thr Arg Ile Met
 1               5                  10                  15
Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly Pro
            20                  25                  30
Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe Tyr
        35                  40                  45
Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr Glu
    50                  55                  60
Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser Ser
65                  70                  75                  80
Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln Tyr
                85                  90                  95
Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn Leu
            100                 105                 110
Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro Asp
        115                 120                 125
Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe Cys
    130                 135                 140
Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu Lys
145                 150                 155                 160
Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu Tyr
                165                 170                 175
Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp Phe
            180                 185                 190
Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro Leu
        195                 200                 205
Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu Tyr
    210                 215                 220
Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg Asn
225                 230                 235                 240
Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val Asp
                245                 250                 255
Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe Ser
            260                 265                 270
Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His Asn
        275                 280                 285
Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser Ser
    290                 295                 300
Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn Ser
305                 310                 315                 320
Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala Tyr
                325                 330                 335
Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp Asn
            340                 345                 350
Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr Ser
        355                 360                 365
Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln Lys
    370                 375                 380
Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu Lys
385                 390                 395                 400
Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His Phe
                405                 410                 415
Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val Thr
            420                 425                 430
Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu Asn
        435                 440                 445
Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro His
    450                 455                 460
Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser Gly
465                 470                 475                 480
Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu Gly
                485                 490                 495
Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp Val
            500                 505                 510
Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn Tyr
        515                 520                 525
Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu Arg
    530                 535                 540
Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn Asp
545                 550                 555                 560
Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu Leu
                565                 570                 575
Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile Thr
            580                 585                 590
His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn Trp
        595                 600                 605
Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile Tyr
    610                 615                 620
Cys Val Tyr Pro Asp Ser Leu Ser Gly Val Ser Leu Phe Ser Leu Ser
625                 630                 635                 640
Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe Ser
                645                 650                 655
Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr Ile
            660                 665                 670
Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys Thr
        675                 680                 685
Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro Asp
    690                 695                 700
Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe Thr
705                 710                 715                 720
Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser Asp
                725                 730                 735
Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro Gly
            740                 745                 750
Glu Asn Arg Pro Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg Lys
        755                 760                 765
Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys Leu
    770                 775                 780
Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn Ser
785                 790                 795                 800
Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu Met
                805                 810                 815
Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu Arg
            820                 825                 830
Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu Ser
        835                 840                 845
Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn Ile
    850                 855                 860
Pro Leu Gln Thr Val Ala Thr Ile Ser
865                 870

<210> 1137
<211> 858
<212> PRT
<213> Homo sapiens

<400> 1137
Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly
 1               5                  10                  15
Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe
            20                  25                  30
Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr
        35                  40                  45
Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser
    50                  55                  60
Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln
65                  70                  75                  80
Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn
                85                  90                  95
Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro
            100                 105                 110
Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe
        115                 120                 125
Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu
    130                 135                 140
Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu
145                 150                 155                 160
Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp
                165                 170                 175
Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro
            180                 185                 190
Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu
        195                 200                 205
Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg
    210                 215                 220
Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val
225                 230                 235                 240
Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe
                245                 250                 255
Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His
            260                 265                 270
Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser
        275                 280                 285
Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn
    290                 295                 300
Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala
305                 310                 315                 320
Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp
                325                 330                 335
Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr
            340                 345                 350
Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln
        355                 360                 365
Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu
    370                 375                 380
Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His
385                 390                 395                 400
Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val
                405                 410                 415
Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu
            420                 425                 430
Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro
        435                 440                 445
His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser
    450                 455                 460
Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu
465                 470                 475                 480
Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp
                485                 490                 495
Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn
            500                 505                 510
Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu
        515                 520                 525
Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn
    530                 535                 540
Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu
545                 550                 555                 560
Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile
                565                 570                 575
Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn
            580                 585                 590
Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile
        595                 600                 605
Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu
    610                 615                 620
Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe
625                 630                 635                 640
Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr
                645                 650                 655
Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys
            660                 665                 670
Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro
        675                 680                 685
Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe
    690                 695                 700
Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser
705                 710                 715                 720
Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro
                725                 730                 735
Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg
            740                 745                 750
Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys
        755                 760                 765
Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn
    770                 775                 780
Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu
785                 790                 795                 800
Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu
                805                 810                 815
Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu
            820                 825                 830
Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn
        835                 840                 845
Ile Pro Leu Gln Thr Val Ala Thr Ile Ser
    850                 855

<210> 1138
<211> 397
<212> PRT
<213> Homo sapiens

<400> 1138
Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn
 1               5                  10                  15
Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys
            20                  25                  30
Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile
        35                  40                  45
Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr
    50                  55                  60
Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly
65                  70                  75                  80
Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly
                85                  90                  95
Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser
            100                 105                 110
Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu
        115                 120                 125
Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys
    130                 135                 140
Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile
145                 150                 155                 160
Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val
                165                 170                 175
Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg
            180                 185                 190
Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu
        195                 200                 205
Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe
    210                 215                 220
His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile
225                 230                 235                 240
Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu
                245                 250                 255
Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly
            260                 265                 270
Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr
        275                 280                 285
Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu
    290                 295                 300
Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu
305                 310                 315                 320
Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro
                325                 330                 335
Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val
            340                 345                 350
Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro
        355                 360                 365
Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp
    370                 375                 380
Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser
385                 390                 395

<210> 1139
<211> 397
<212> PRT
<213> Homo sapiens

<400> 1139
Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn
 1               5                  10                  15
Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys
            20                  25                  30
Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile
        35                  40                  45
Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr
    50                  55                  60
Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly
65                  70                  75                  80
Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly
                85                  90                  95
Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser
            100                 105                 110
Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu
        115                 120                 125
Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys
    130                 135                 140
Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile
145                 150                 155                 160
Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val
                165                 170                 175
Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg
            180                 185                 190
Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu
        195                 200                 205
Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe
    210                 215                 220
His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile
225                 230                 235                 240
Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu
                245                 250                 255
Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly
            260                 265                 270
Phe His Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr
        275                 280                 285
Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu
    290                 295                 300
Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu
305                 310                 315                 320
Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro
                325                 330                 335
Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val
            340                 345                 350
Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro
        355                 360                 365
Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp
    370                 375                 380
Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser
385                 390                 395

<210> 1140
<211> 397
<212> PRT
<213> Homo sapiens

<400> 1140
Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn
 1               5                  10                  15
Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys
            20                  25                  30
Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile
        35                  40                  45
Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr
    50                  55                  60
Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly
65                  70                  75                  80
Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly
                85                  90                  95
Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser
            100                 105                 110
Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu
        115                 120                 125
Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys
    130                 135                 140
Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile
145                 150                 155                 160
Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val
                165                 170                 175
Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg
            180                 185                 190
Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu
        195                 200                 205
Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe
    210                 215                 220
His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile
225                 230                 235                 240
Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu
                245                 250                 255
Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly
            260                 265                 270
Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr
        275                 280                 285
Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu
    290                 295                 300
Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu
305                 310                 315                 320
Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro
                325                 330                 335
Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val
            340                 345                 350
Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro
        355                 360                 365
Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp
    370                 375                 380
Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser
385                 390                 395

<210> 1141
<211> 258
<212> PRT
<213> Homo sapiens

<400> 1141
Met Gln Ile Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile
 1               5                  10                  15
Gln Ser Val Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro
            20                  25                  30
Lys Asp Arg Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys
        35                  40                  45
Lys Ile Leu Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys
    50                  55                  60
Ile Thr Phe His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly
65                  70                  75                  80
Asp Ile Ile Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg
                85                  90                  95
Arg Gly Glu Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala
            100                 105                 110
Leu Cys Gly Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile
        115                 120                 125
Val Ile Thr Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys
    130                 135                 140
Cys Val Leu Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys
145                 150                 155                 160
Gly Arg Leu Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe
                165                 170                 175
Leu Ser Pro Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg
            180                 185                 190
Lys Glu Val Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp
        195                 200                 205
Phe Asp Pro Asn Gln Glu Arg Arg Gly His Tyr Asn Gly Glu Ala Tyr
    210                 215                 220
Glu Asp Asp Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser
225                 230                 235                 240
Leu Asn Gly Pro Val Asn Asn Thr His Cys Trp His Leu Met Cys Ser
                245                 250                 255
Ser Glu


<210> 1142
<211> 165
<212> PRT
<213> Homo sapiens

<400> 1142
Gly Ala Gly Gly Gly Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe
 1               5                  10                  15
Phe Gly Gly Gly Gly Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val
            20                  25                  30
Val His Gln Leu Ser Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr
        35                  40                  45
Arg Lys Leu Ala Leu Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly
    50                  55                  60
Arg Gly Gly Lys Lys Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly
65                  70                  75                  80
Thr Gly Met Gln Ile Arg Ile His Gln Ile Gly Pro Gly Met Val Gln
                85                  90                  95
Gln Ile Gln Ser Val Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile
            100                 105                 110
Ser Pro Lys Asp Arg Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg
        115                 120                 125
Glu Lys Lys Ile Leu Glu Val His Ile Asp Lys Gly Met Lys Asp Gly
    130                 135                 140
Gln Lys Ile Thr Phe His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu
145                 150                 155                 160
Pro Gly Asp Ile Ile
                165

<210> 1143
<211> 397
<212> PRT
<213> Homo sapiens

<400> 1143
Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn
 1               5                  10                  15
Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys
            20                  25                  30
Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile
        35                  40                  45
Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr
    50                  55                  60
Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly
65                  70                  75                  80
Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly
                85                  90                  95
Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser
            100                 105                 110
Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu
        115                 120                 125
Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys
    130                 135                 140
Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile
145                 150                 155                 160
Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val
                165                 170                 175
Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg
            180                 185                 190
Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu
        195                 200                 205
Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe
    210                 215                 220
His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile
225                 230                 235                 240
Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu
                245                 250                 255
Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly
            260                 265                 270
Phe His Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr
        275                 280                 285
Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu
    290                 295                 300
Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu
305                 310                 315                 320
Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro
                325                 330                 335
Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val
            340                 345                 350
Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro
        355                 360                 365
Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp
    370                 375                 380
Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser
385                 390                 395

<210> 1144
<211> 397
<212> PRT
<213> Homo sapiens

<400> 1144
Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn
 1               5                  10                  15
Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys
            20                  25                  30
Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile
        35                  40                  45
Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr
    50                  55                  60
Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly
65                  70                  75                  80
Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly
                85                  90                  95
Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser
            100                 105                 110
Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu
        115                 120                 125
Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys
    130                 135                 140
Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile
145                 150                 155                 160
Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val
                165                 170                 175
Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg
            180                 185                 190
Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu
        195                 200                 205
Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe
    210                 215                 220
His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile
225                 230                 235                 240
Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu
                245                 250                 255
Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly
            260                 265                 270
Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr
        275                 280                 285
Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu
    290                 295                 300
Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu
305                 310                 315                 320
Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro
                325                 330                 335
Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val
            340                 345                 350
Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro
        355                 360                 365
Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp
    370                 375                 380
Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser
385                 390                 395

<210> 1145
<211> 397
<212> PRT
<213> Homo sapiens

<400> 1145
Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn
 1               5                  10                  15
Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys
            20                  25                  30
Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile
        35                  40                  45
Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr
    50                  55                  60
Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly
65                  70                  75                  80
Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly
                85                  90                  95
Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser
            100                 105                 110
Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu
        115                 120                 125
Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys
    130                 135                 140
Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile
145                 150                 155                 160
Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val
                165                 170                 175
Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg
            180                 185                 190
Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu
        195                 200                 205
Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe
    210                 215                 220
His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile
225                 230                 235                 240
Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu
                245                 250                 255
Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly
            260                 265                 270
Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr
        275                 280                 285
Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu
    290                 295                 300
Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu
305                 310                 315                 320
Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro
                325                 330                 335
Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val
            340                 345                 350
Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro
        355                 360                 365
Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp
    370                 375                 380
Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser
385                 390                 395

<210> 1146
<211> 258
<212> PRT
<213> Homo sapiens

<400> 1146
Met Gln Ile Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile
 1               5                  10                  15
Gln Ser Val Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro
            20                  25                  30
Lys Asp Arg Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys
        35                  40                  45
Lys Ile Leu Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys
    50                  55                  60
Ile Thr Phe His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly
65                  70                  75                  80
Asp Ile Ile Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg
                85                  90                  95
Arg Gly Glu Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala
            100                 105                 110
Leu Cys Gly Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile
        115                 120                 125
Val Ile Thr Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys
    130                 135                 140
Cys Val Leu Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys
145                 150                 155                 160
Gly Arg Leu Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe
                165                 170                 175
Leu Ser Pro Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg
            180                 185                 190
Lys Glu Val Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp
        195                 200                 205
Phe Asp Pro Asn Gln Glu Arg Arg Gly His Tyr Asn Gly Glu Ala Tyr
    210                 215                 220
Glu Asp Asp Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser
225                 230                 235                 240
Leu Asn Gly Pro Val Asn Asn Thr His Cys Trp His Leu Met Cys Ser
                245                 250                 255
Ser Glu


<210> 1147
<211> 1461
<212> PRT
<213> Homo sapiens

<400> 1147
Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe
 1               5                  10                  15
Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala
            20                  25                  30
Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg
        35                  40                  45
Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser
    50                  55                  60
Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro
65                  70                  75                  80
Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val
                85                  90                  95
Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser
            100                 105                 110
Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln
        115                 120                 125
Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala
    130                 135                 140
Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro
145                 150                 155                 160
Ser Ser Val Tyr Ala Gly Asn Gly Ala Ile Leu Asn Cys Glu Val Asn
                165                 170                 175
Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu
            180                 185                 190
Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile
        195                 200                 205
Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu
    210                 215                 220
Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu
225                 230                 235                 240
Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser
                245                 250                 255
Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala
            260                 265                 270
Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala
        275                 280                 285
Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser
    290                 295                 300
Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys
305                 310                 315                 320
Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr
                325                 330                 335
Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala
            340                 345                 350
His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro
        355                 360                 365
Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser
    370                 375                 380
Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu
385                 390                 395                 400
Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val
                405                 410                 415
Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro
            420                 425                 430
Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser
        435                 440                 445
Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser
    450                 455                 460
Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu
465                 470                 475                 480
Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met
                485                 490                 495
Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg
            500                 505                 510
Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu
        515                 520                 525
Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn
    530                 535                 540
Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu
545                 550                 555                 560
Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr
                565                 570                 575
Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His
            580                 585                 590
Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg
        595                 600                 605
Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val
    610                 615                 620
Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu
625                 630                 635                 640
Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro
                645                 650                 655
Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg
            660                 665                 670
Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser
        675                 680                 685
Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu
    690                 695                 700
Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala
705                 710                 715                 720
Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr
                725                 730                 735
Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr
            740                 745                 750
Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val
        755                 760                 765
Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr
    770                 775                 780
Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp
785                 790                 795                 800
Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly
                805                 810                 815
Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp
            820                 825                 830
Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val
        835                 840                 845
Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile
    850                 855                 860
Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro
865                 870                 875                 880
Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys
                885                 890                 895
Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr
            900                 905                 910
Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe
        915                 920                 925
Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr
    930                 935                 940
Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp
945                 950                 955                 960
Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn
                965                 970                 975
Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile
            980                 985                 990
Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu
        995                 1000                1005
Pro Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr Leu
    1010                1015                1020
Asp Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys Gly Met
1025                1030                1035                1040
Gly Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys Ala Asp Ser
                1045                1050                1055
Ser Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser Gly Gly Lys Gly
            1060                1065                1070
Ser Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys Pro Pro Met Ser Gly
        1075                1080                1085
Ser Asn Ser Pro His Gly Ser Pro Thr Ser Pro Leu Asp Ser Asn Met
    1090                1095                1100
Leu Leu Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val Val
1105                1110                1115                1120
Val Ile Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln Lys
                1125                1130                1135
Lys Lys Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr Lys
            1140                1145                1150
Gly Asn Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His Glu
        1155                1160                1165
Arg Leu Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile
    1170                1175                1180
Met Thr Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val
1185                1190                1195                1200
Asp Asn Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg
                1205                1210                1215
Gly His Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly
            1220                1225                1230
Met Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Pro
        1235                1240                1245
Val Ile Ser Ala His Pro Ile His Ser Leu Asp Asn Pro His His His
    1250                1255                1260
Phe His Ser Ser Ser Leu Ala Ser Pro Ala Arg Ser His Leu Tyr His
1265                1270                1275                1280
Pro Gly Ser Pro Trp Pro Ile Gly Thr Ser Met Ser Leu Ser Asp Arg
                1285                1290                1295
Ala Asn Ser Thr Glu Ser Val Arg Asn Thr Pro Ser Thr Asp Thr Met
            1300                1305                1310
Pro Ala Ser Ser Ser Gln Thr Cys Cys Thr Asp His Gln Asp Pro Glu
        1315                1320                1325
Gly Ala Thr Ser Ser Ser Tyr Leu Ala Ser Ser Gln Glu Glu Asp Ser
    1330                1335                1340
Gly Gln Ser Leu Pro Thr Ala His Val Arg Pro Ser His Pro Leu Lys
1345                1350                1355                1360
Ser Phe Ala Val Pro Ala Ile Pro Pro Pro Gly Pro Pro Thr Tyr Asp
                1365                1370                1375
Pro Ala Leu Pro Ser Thr Pro Leu Leu Ser Gln Gln Ala Leu Asn His
            1380                1385                1390
His Ile His Ser Val Lys Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser
        1395                1400                1405
Arg Pro Pro Met Pro Val Val Val Pro Ser Ala Pro Glu Val Gln Glu
    1410                1415                1420
Thr Thr Arg Met Leu Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu
1425                1430                1435                1440
Leu Thr Lys Glu Met Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn
                1445                1450                1455
Ala Ile Thr Thr Ala
            1460

<210> 1148
<211> 1461
<212> PRT
<213> Homo sapiens

<400> 1148
Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe
 1               5                  10                  15
Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala
            20                  25                  30
Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg
        35                  40                  45
Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser
    50                  55                  60
Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro
65                  70                  75                  80
Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val
                85                  90                  95
Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser
            100                 105                 110
Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln
        115                 120                 125
Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala
    130                 135                 140
Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro
145                 150                 155                 160
Ser Ser Val Tyr Ala Gly Asn Asn Ala Ile Leu Asn Cys Glu Val Asn
                165                 170                 175
Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu
            180                 185                 190
Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile
        195                 200                 205
Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu
    210                 215                 220
Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu
225                 230                 235                 240
Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser
                245                 250                 255
Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala
            260                 265                 270
Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala
        275                 280                 285
Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser
    290                 295                 300
Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys
305                 310                 315                 320
Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr
                325                 330                 335
Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala
            340                 345                 350
His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro
        355                 360                 365
Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser
    370                 375                 380
Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu
385                 390                 395                 400
Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val
                405                 410                 415
Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro
            420                 425                 430
Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser
        435                 440                 445
Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser
    450                 455                 460
Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu
465                 470                 475                 480
Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met
                485                 490                 495
Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg
            500                 505                 510
Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu
        515                 520                 525
Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn
    530                 535                 540
Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu
545                 550                 555                 560
Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr
                565                 570                 575
Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His
            580                 585                 590
Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg
        595                 600                 605
Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val
    610                 615                 620
Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu
625                 630                 635                 640
Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro
                645                 650                 655
Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg
            660                 665                 670
Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser
        675                 680                 685
Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu
    690                 695                 700
Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala
705                 710                 715                 720
Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr
                725                 730                 735
Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr
            740                 745                 750
Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val
        755                 760                 765
Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr
    770                 775                 780
Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp
785                 790                 795                 800
Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly
                805                 810                 815
Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp
            820                 825                 830
Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val
        835                 840                 845
Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile
    850                 855                 860
Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro
865                 870                 875                 880
Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys
                885                 890                 895
Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr
            900                 905                 910
Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe
        915                 920                 925
Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr
    930                 935                 940
Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp
945                 950                 955                 960
Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn
                965                 970                 975
Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile
            980                 985                 990
Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu
        995                 1000                1005
Pro Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr Leu
    1010                1015                1020
Asp Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys Gly Met
1025                1030                1035                1040
Gly Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys Ala Asp Ser
                1045                1050                1055
Ser Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser Gly Gly Lys Gly
            1060                1065                1070
Ser Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys Pro Pro Met Ser Gly
        1075                1080                1085
Ser Asn Ser Pro His Gly Ser Pro Thr Ser Pro Leu Asp Ser Asn Met
    1090                1095                1100
Leu Leu Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val Val
1105                1110                1115                1120
Val Ile Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln Lys
                1125                1130                1135
Lys Lys Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr Lys
            1140                1145                1150
Gly Asn Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His Glu
        1155                1160                1165
Arg Leu Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile
    1170                1175                1180
Met Thr Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val
1185                1190                1195                1200
Asp Asn Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg
                1205                1210                1215
Gly His Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly
            1220                1225                1230
Met Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Pro
        1235                1240                1245
Val Ile Ser Ala His Pro Ile His Ser Leu Asp Asn Pro His His His
    1250                1255                1260
Phe His Ser Ser Ser Leu Ala Ser Pro Ala Arg Ser His Leu Tyr His
1265                1270                1275                1280
Pro Gly Ser Pro Trp Pro Ile Gly Thr Ser Met Ser Leu Ser Asp Arg
                1285                1290                1295
Ala Asn Ser Thr Glu Ser Val Arg Asn Thr Pro Ser Thr Asp Thr Met
            1300                1305                1310
Pro Ala Ser Ser Ser Gln Thr Cys Cys Thr Asp His Gln Asp Pro Glu
        1315                1320                1325
Gly Ala Thr Ser Ser Ser Tyr Leu Ala Ser Ser Gln Glu Glu Asp Ser
    1330                1335                1340
Gly Gln Ser Leu Pro Thr Ala His Val Arg Pro Ser His Pro Leu Lys
1345                1350                1355                1360
Ser Phe Ala Val Pro Ala Ile Pro Pro Pro Gly Pro Pro Thr Tyr Asp
                1365                1370                1375
Pro Ala Leu Pro Ser Thr Pro Leu Leu Ser Gln Gln Ala Leu Asn His
            1380                1385                1390
His Ile His Ser Val Lys Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser
        1395                1400                1405
Arg Pro Pro Met Pro Val Val Val Pro Ser Ala Pro Glu Val Gln Glu
    1410                1415                1420
Thr Thr Arg Met Leu Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu
1425                1430                1435                1440
Leu Thr Lys Glu Met Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn
                1445                1450                1455
Ala Ile Thr Thr Ala
            1460

<210> 1149
<211> 1461
<212> PRT
<213> Homo sapiens

<400> 1149
Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe
 1               5                  10                  15
Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala
            20                  25                  30
Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg
        35                  40                  45
Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser
    50                  55                  60
Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro
65                  70                  75                  80
Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val
                85                  90                  95
Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser
            100                 105                 110
Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln
        115                 120                 125
Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala
    130                 135                 140
Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro
145                 150                 155                 160
Ser Ser Val Tyr Ala Gly Asn Gly Ala Ile Leu Asn Cys Glu Val Asn
                165                 170                 175
Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu
            180                 185                 190
Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile
        195                 200                 205
Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu
    210                 215                 220
Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu
225                 230                 235                 240
Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser
                245                 250                 255
Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala
            260                 265                 270
Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala
        275                 280                 285
Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser
    290                 295                 300
Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys
305                 310                 315                 320
Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr
                325                 330                 335
Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala
            340                 345                 350
His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro
        355                 360                 365
Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser
    370                 375                 380
Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu
385                 390                 395                 400
Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val
                405                 410                 415
Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro
            420                 425                 430
Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser
        435                 440                 445
Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser
    450                 455                 460
Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu
465                 470                 475                 480
Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met
                485                 490                 495
Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg
            500                 505                 510
Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu
        515                 520                 525
Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn
    530                 535                 540
Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu
545                 550                 555                 560
Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr
                565                 570                 575
Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His
            580                 585                 590
Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg
        595                 600                 605
Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val
    610                 615                 620
Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu
625                 630                 635                 640
Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro
                645                 650                 655
Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg
            660                 665                 670
Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser
        675                 680                 685
Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu
    690                 695                 700
Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala
705                 710                 715                 720
Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr
                725                 730                 735
Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr
            740                 745                 750
Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val
        755                 760                 765
Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr
    770                 775                 780
Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp
785                 790                 795                 800
Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly
                805                 810                 815
Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp
            820                 825                 830
Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val
        835                 840                 845
Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile
    850                 855                 860
Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro
865                 870                 875                 880
Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys
                885                 890                 895
Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr
            900                 905                 910
Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe
        915                 920                 925
Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr
    930                 935                 940
Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp
945                 950                 955                 960
Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn
                965                 970                 975
Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile
            980                 985                 990
Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu
        995                 1000                1005
Pro Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr Leu
    1010                1015                1020
Asp Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys Gly Met
1025                1030                1035                1040
Gly Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys Ala Asp Ser
                1045                1050                1055
Ser Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser Gly Gly Lys Gly
            1060                1065                1070
Ser Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys Pro Pro Met Ser Gly
        1075                1080                1085
Ser Asn Ser Pro His Gly Ser Pro Thr Ser Pro Leu Asp Ser Asn Met
    1090                1095                1100
Leu Leu Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val Val
1105                1110                1115                1120
Val Ile Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln Lys
                1125                1130                1135
Lys Lys Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr Lys
            1140                1145                1150
Gly Asn Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His Glu
        1155                1160                1165
Arg Leu Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile
    1170                1175                1180
Met Thr Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val
1185                1190                1195                1200
Asp Asn Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg
                1205                1210                1215
Gly His Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly
            1220                1225                1230
Met Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Pro
        1235                1240                1245
Val Ile Ser Ala His Pro Ile His Ser Leu Asp Asn Pro His His His
    1250                1255                1260
Phe His Ser Ser Ser Leu Ala Ser Pro Ala Arg Ser His Leu Tyr His
1265                1270                1275                1280
Pro Gly Ser Pro Trp Pro Ile Gly Thr Ser Met Ser Leu Ser Asp Arg
                1285                1290                1295
Ala Asn Ser Thr Glu Ser Val Arg Asn Thr Pro Ser Thr Asp Thr Met
            1300                1305                1310
Pro Ala Ser Ser Ser Gln Thr Cys Cys Thr Asp His Gln Asp Pro Glu
        1315                1320                1325
Gly Ala Thr Ser Ser Ser Tyr Leu Ala Ser Ser Gln Glu Glu Asp Ser
    1330                1335                1340
Gly Gln Ser Leu Pro Thr Ala His Val Arg Pro Ser His Pro Leu Lys
1345                1350                1355                1360
Ser Phe Ala Val Pro Ala Ile Pro Pro Pro Gly Pro Pro Thr Tyr Asp
                1365                1370                1375
Pro Ala Leu Pro Ser Thr Pro Leu Leu Ser Gln Gln Ala Leu Asn His
            1380                1385                1390
His Ile His Ser Val Lys Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser
        1395                1400                1405
Arg Pro Pro Met Pro Val Val Val Pro Ser Ala Pro Glu Val Gln Glu
    1410                1415                1420
Thr Thr Arg Met Leu Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu
1425                1430                1435                1440
Leu Thr Lys Glu Met Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn
                1445                1450                1455
Ala Ile Thr Thr Ala
            1460

<210> 1150
<211> 1461
<212> PRT
<213> Homo sapiens

<400> 1150
Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe
 1               5                  10                  15
Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala
            20                  25                  30
Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg
        35                  40                  45
Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser
    50                  55                  60
Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro
65                  70                  75                  80
Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val
                85                  90                  95
Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser
            100                 105                 110
Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln
        115                 120                 125
Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala
    130                 135                 140
Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro
145                 150                 155                 160
Ser Ser Val Tyr Ala Gly Asn Gly Ala Ile Leu Asn Cys Glu Val Asn
                165                 170                 175
Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu
            180                 185                 190
Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile
        195                 200                 205
Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu
    210                 215                 220
Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu
225                 230                 235                 240
Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser
                245                 250                 255
Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala
            260                 265                 270
Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala
        275                 280                 285
Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser
    290                 295                 300
Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys
305                 310                 315                 320
Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr
                325                 330                 335
Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala
            340                 345                 350
His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro
        355                 360                 365
Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser
    370                 375                 380
Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu
385                 390                 395                 400
Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val
                405                 410                 415
Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro
            420                 425                 430
Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser
        435                 440                 445
Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser
    450                 455                 460
Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu
465                 470                 475                 480
Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met
                485                 490                 495
Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg
            500                 505                 510
Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu
        515                 520                 525
Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn
    530                 535                 540
Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu
545                 550                 555                 560
Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr
                565                 570                 575
Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His
            580                 585                 590
Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg
        595                 600                 605
Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val
    610                 615                 620
Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu
625                 630                 635                 640
Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro
                645                 650                 655
Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg
            660                 665                 670
Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser
        675                 680                 685
Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu
    690                 695                 700
Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala
705                 710                 715                 720
Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr
                725                 730                 735
Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr
            740                 745                 750
Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val
        755                 760                 765
Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr
    770                 775                 780
Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp
785                 790                 795                 800
Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly
                805                 810                 815
Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp
            820                 825                 830
Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val
        835                 840                 845
Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile
    850                 855                 860
Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro
865                 870                 875                 880
Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys
                885                 890                 895
Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr
            900                 905                 910
Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe
        915                 920                 925
Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr
    930                 935                 940
Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp
945                 950                 955                 960
Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn
                965                 970                 975
Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile
            980                 985                 990
Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu
        995                 1000                1005
Pro Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr Leu
    1010                1015                1020
Asp Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys Gly Met
1025                1030                1035                1040
Gly Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys Ala Asp Ser
                1045                1050                1055
Ser Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser Gly Gly Lys Gly
            1060                1065                1070
Ser Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys Pro Pro Met Ser Gly
        1075                1080                1085
Ser Asn Ser Pro His Gly Ser Pro Thr Ser Pro Leu Asp Ser Asn Met
    1090                1095                1100
Leu Leu Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val Val
1105                1110                1115                1120
Val Ile Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln Lys
                1125                1130                1135
Lys Lys Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr Lys
            1140                1145                1150
Gly Asn Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His Glu
        1155                1160                1165
Arg Leu Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile
    1170                1175                1180
Met Thr Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val
1185                1190                1195                1200
Asp Asn Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg
                1205                1210                1215
Gly His Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly
            1220                1225                1230
Met Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Pro
        1235                1240                1245
Val Ile Ser Ala His Pro Ile His Ser Leu Asp Asn Pro His His His
    1250                1255                1260
Phe His Ser Ser Ser Leu Ala Ser Pro Ala Arg Ser His Leu Tyr His
1265                1270                1275                1280
Pro Gly Ser Pro Trp Pro Ile Gly Thr Ser Met Ser Leu Ser Asp Arg
                1285                1290                1295
Ala Asn Ser Thr Glu Ser Val Arg Asn Thr Pro Ser Thr Asp Thr Met
            1300                1305                1310
Pro Ala Ser Ser Ser Gln Thr Cys Cys Thr Asp His Gln Asp Pro Glu
        1315                1320                1325
Gly Ala Thr Ser Ser Ser Tyr Leu Ala Ser Ser Gln Glu Glu Asp Ser
    1330                1335                1340
Gly Gln Ser Leu Pro Thr Ala His Val Arg Pro Ser His Pro Leu Lys
1345                1350                1355                1360
Ser Phe Ala Val Pro Ala Ile Pro Pro Pro Gly Pro Pro Thr Tyr Asp
                1365                1370                1375
Pro Ala Leu Pro Ser Thr Pro Leu Leu Ser Gln Gln Ala Leu Asn His
            1380                1385                1390
His Ile His Ser Val Lys Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser
        1395                1400                1405
Arg Pro Pro Met Pro Val Val Val Pro Ser Ala Pro Glu Val Gln Glu
    1410                1415                1420
Thr Thr Arg Met Leu Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu
1425                1430                1435                1440
Leu Thr Lys Glu Met Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn
                1445                1450                1455
Ala Ile Thr Thr Ala
            1460

<210> 1151
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1151
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1152
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1152
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1153
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1153
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1154
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1154
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1155
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1155
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1156
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1156
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1157
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1157
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1158
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1158
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1159
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1159
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1160
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1160
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1161
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1161
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1162
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1162
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1163
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1163
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1164
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1164
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1165
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1165
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1166
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1166
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1167
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1167
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1168
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1168
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1169
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1169
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1170
<211> 483
<212> PRT
<213> Homo sapiens

<400> 1170
Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val Ser Leu Met Val
 1               5                  10                  15
Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val Asn Pro Gly Val
            20                  25                  30
Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala Ser Gln Gln Gly
        35                  40                  45
Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys Ile Pro Asp Tyr
    50                  55                  60
Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly His Tyr Ser Phe
65                  70                  75                  80
Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser Ser Gln Ile Ser
                85                  90                  95
Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser Asn Ala Asn Ile
            100                 105                 110
Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe Leu Lys Met Ser
        115                 120                 125
Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile Ser Ala Asp Leu
    130                 135                 140
Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr Ile Thr Cys Ser
145                 150                 155                 160
Ser Cys Ser Ser His Ile Asn Ser Val His Val His Ile Ser Lys Ser
                165                 170                 175
Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys Ile Glu Ser Ala
            180                 185                 190
Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys Val Thr Asn Ser
        195                 200                 205
Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu Pro Val Met Thr
    210                 215                 220
Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro
225                 230                 235                 240
Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr
                245                 250                 255
Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu
            260                 265                 270
Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr
        275                 280                 285
Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys
    290                 295                 300
Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu
305                 310                 315                 320
Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe
                325                 330                 335
Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His
            340                 345                 350
Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val
        355                 360                 365
Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu
    370                 375                 380
Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn
385                 390                 395                 400
Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys
                405                 410                 415
His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met
            420                 425                 430
Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu
        435                 440                 445
Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn
    450                 455                 460
Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val
465                 470                 475                 480
Val Tyr Lys


<210> 1171
<211> 481
<212> PRT
<213> Homo sapiens

<400> 1171
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Glu Phe Gln Leu Pro Ser Ser Gln Ile Ser Met Val
                85                  90                  95
Pro Asn Val Gly Leu Lys Phe Ser Ile Ser Asn Ala Asn Ile Lys Ile
            100                 105                 110
Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe Leu Lys Met Ser Gly Asn
        115                 120                 125
Phe Asp Leu Ser Ile Glu Gly Met Ser Ile Ser Ala Asp Leu Lys Leu
    130                 135                 140
Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr Ile Thr Cys Ser Ser Cys
145                 150                 155                 160
Ser Ser His Ile Asn Ser Val His Val His Ile Ser Lys Ser Lys Val
                165                 170                 175
Gly Trp Leu Ile Gln Leu Phe His Lys Lys Ile Glu Ser Ala Leu Arg
            180                 185                 190
Asn Lys Met Asn Ser Gln Val Cys Glu Lys Val Thr Asn Ser Val Ser
        195                 200                 205
Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu Pro Val Met Thr Lys Ile
    210                 215                 220
Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro Ala Thr
225                 230                 235                 240
Thr Ala Glu Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr Ser Glu
                245                 250                 255
Asn His His Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu Phe Pro
            260                 265                 270
Ala Ala His Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe
        275                 280                 285
Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr
    290                 295                 300
Leu Arg Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr
305                 310                 315                 320
Lys Phe Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn
                325                 330                 335
Met Lys Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser
            340                 345                 350
Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val Gln Ala
        355                 360                 365
Leu Ala Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly
    370                 375                 380
Met His Thr Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn Arg Leu
385                 390                 395                 400
Val Gly Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser
                405                 410                 415
Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr
            420                 425                 430
Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys
        435                 440                 445
Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val
    450                 455                 460
Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr
465                 470                 475                 480
Lys


<210> 1172
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1172
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1173
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1173
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1174
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1174
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1175
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1175
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1176
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1176
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Met Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Arg His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1177
<211> 454
<212> PRT
<213> Homo sapiens

<400> 1177
Ala Asn Pro Gly Leu Val Ala Arg Ile Thr Asp Lys Gly Leu Gln Tyr
 1               5                  10                  15
Ala Ala Gln Glu Gly Leu Leu Ala Leu Gln Ser Glu Leu Leu Arg Ile
            20                  25                  30
Thr Leu Pro Asp Phe Thr Gly Asp Leu Arg Ile Pro His Val Gly Arg
        35                  40                  45
Gly Arg Tyr Glu Phe His Ser Leu Asn Ile His Ser Cys Glu Leu Leu
    50                  55                  60
His Ser Ala Leu Arg Pro Val Pro Gly Gln Gly Leu Ser Leu Ser Ile
65                  70                  75                  80
Ser Asp Ser Ser Ile Arg Val Gln Gly Arg Trp Lys Val Arg Lys Ser
                85                  90                  95
Phe Phe Lys Leu Gln Gly Ser Phe Asp Val Ser Val Lys Gly Ile Ser
            100                 105                 110
Ile Ser Val Asn Leu Leu Leu Gly Ser Glu Ser Ser Gly Arg Pro Thr
        115                 120                 125
Gly Tyr Cys Leu Ser Cys Ser Ser Asp Ile Ala Asp Val Glu Val Asp
    130                 135                 140
Met Ser Gly Asp Ser Gly Trp Leu Leu Asn Leu Phe His Asn Gln Ile
145                 150                 155                 160
Glu Ser Lys Phe Gln Lys Val Leu Glu Ser Arg Ile Cys Glu Met Ile
                165                 170                 175
Gln Lys Ser Val Ser Ser Asp Leu Gln Pro Tyr Leu Gln Thr Leu Pro
            180                 185                 190
Val Thr Thr Glu Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu Val
        195                 200                 205
Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys Gly
    210                 215                 220
Glu Phe Thr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro Pro
225                 230                 235                 240
Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly Leu
                245                 250                 255
Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala Gly
            260                 265                 270
Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser Lys
        275                 280                 285
Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val Ala
    290                 295                 300
Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser Thr
305                 310                 315                 320
Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro Ala
                325                 330                 335
Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala Ser
            340                 345                 350
Leu Pro Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser Ala
        355                 360                 365
Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu Leu
    370                 375                 380
Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln
385                 390                 395                 400
Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn
                405                 410                 415
Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln
            420                 425                 430
Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly
        435                 440                 445
Ala Asp Val Val Tyr Lys
    450

<210> 1178
<211> 456
<212> PRT
<213> Homo sapiens

<400> 1178
Val Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr
 1               5                  10                  15
Ala Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile
            20                  25                  30
Lys Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys
        35                  40                  45
Gly His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro
    50                  55                  60
Ser Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile
65                  70                  75                  80
Ser Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg
                85                  90                  95
Phe Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser
            100                 105                 110
Ile Ser Ala Asp Leu Lys Leu Lys Ser Asn Pro Thr Ser Gly Lys Pro
        115                 120                 125
Thr Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val
    130                 135                 140
His Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys
145                 150                 155                 160
Lys Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu
                165                 170                 175
Lys Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr
            180                 185                 190
Leu Pro Val Met Thr Lys Ile Asp Pro Val Ala Gly Ile Asn Tyr Gly
        195                 200                 205
Leu Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met
    210                 215                 220
Lys Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala
225                 230                 235                 240
Pro Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu
                245                 250                 255
Gly Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu
            260                 265                 270
Ala Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu
        275                 280                 285
Ser Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu
    290                 295                 300
Val Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala
305                 310                 315                 320
Ser Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr
                325                 330                 335
Pro Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ala Leu
            340                 345                 350
Ala Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val
        355                 360                 365
Ser Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu
    370                 375                 380
Leu Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu
385                 390                 395                 400
Leu Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg
                405                 410                 415
Val Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg
            420                 425                 430
Val Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu
        435                 440                 445
Phe Gly Ala Asp Val Val Tyr Lys
    450                 455

<210> 1179
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1179
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Cys Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1180
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1180
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Glu Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val His Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1181
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1181
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1182
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1182
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1183
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1183
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1184
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1184
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1185
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1185
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1186
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1186
Met Arg Asp Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Gln Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1187
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1187
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1188
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1188
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1189
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1189
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1190
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1190
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1191
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1191
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1192
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1192
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1193
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1193
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Glu Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Ala
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1194
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1194
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1195
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1195
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1196
<211> 479
<212> PRT
<213> Homo sapiens

<400> 1196
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Leu Gly Trp
                165                 170                 175
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190
Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp
        195                 200                 205
Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser
    210                 215                 220
Val Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro Ala Thr Thr Ala
225                 230                 235                 240
Glu Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr Ser Glu Asn His
                245                 250                 255
His Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu Phe Pro Ala Ala
            260                 265                 270
His Asp Arg His Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe Asn Thr
        275                 280                 285
Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr Leu Arg
    290                 295                 300
Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr Lys Phe
305                 310                 315                 320
Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn Met Lys
                325                 330                 335
Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser Val Gln
            340                 345                 350
Pro Thr Gly Leu Thr Glu Tyr Pro Ala Val Asp Val Gln Ala Leu Ala
        355                 360                 365
Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly Met His
    370                 375                 380
Thr Thr Gly Ser His Glu Val Ser Ala Glu Ser Asn Arg Leu Val Gly
385                 390                 395                 400
Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser Asn Ile
                405                 410                 415
Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr Ile Val
            420                 425                 430
Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys Gly Phe
        435                 440                 445
Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val Leu Gln
    450                 455                 460
Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr Lys
465                 470                 475

<210> 1197
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1197
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1198
<211> 479
<212> PRT
<213> Homo sapiens

<400> 1198
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Val Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Phe Gly Trp
                165                 170                 175
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190
Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp
        195                 200                 205
Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser
    210                 215                 220
Val Ala Gly Ile Asp Tyr Gly Leu Val Ala Pro Pro Ala Thr Thr Ala
225                 230                 235                 240
Glu Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr Ser Glu Asn His
                245                 250                 255
His Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu Phe Pro Ala Ala
            260                 265                 270
His Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe Asn Thr
        275                 280                 285
Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr Leu Arg
    290                 295                 300
Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr Lys Phe
305                 310                 315                 320
Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn Met Lys
                325                 330                 335
Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser Val Gln
            340                 345                 350
Pro Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val Gln Ala Leu Ala
        355                 360                 365
Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly Met His
    370                 375                 380
Thr Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn Arg Leu Val Gly
385                 390                 395                 400
Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser Asn Ile
                405                 410                 415
Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr Ile Val
            420                 425                 430
Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys Gly Phe
        435                 440                 445
Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val Leu Gln
    450                 455                 460
Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr Lys
465                 470                 475

<210> 1199
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1199
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ala Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1200
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1200
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Pro Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1201
<211> 479
<212> PRT
<213> Homo sapiens

<400> 1201
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Leu Gly Trp
                165                 170                 175
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190
Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp
        195                 200                 205
Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ala
    210                 215                 220
Val Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro Ala Thr Thr Ala
225                 230                 235                 240
Glu Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr Ser Glu Asn His
                245                 250                 255
His Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu Phe Pro Ala Ala
            260                 265                 270
His Asp Arg His Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe Asn Thr
        275                 280                 285
Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr Leu Arg
    290                 295                 300
Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr Lys Phe
305                 310                 315                 320
Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn Met Lys
                325                 330                 335
Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser Val Gln
            340                 345                 350
Pro Thr Gly Leu Thr Glu Tyr Pro Ala Val Asp Val Gln Ala Leu Ala
        355                 360                 365
Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly Met His
    370                 375                 380
Thr Thr Gly Ser His Glu Val Ser Ala Glu Ser Asn Arg Leu Val Gly
385                 390                 395                 400
Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser Asn Ile
                405                 410                 415
Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr Ile Val
            420                 425                 430
Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys Gly Phe
        435                 440                 445
Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val Leu Gln
    450                 455                 460
Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr Lys
465                 470                 475

<210> 1202
<211> 257
<212> PRT
<213> Homo sapiens

<400> 1202
Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro Ala Thr
 1               5                  10                  15
Thr Ala Glu Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr Ser Glu
            20                  25                  30
Asn His His Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu Phe Pro
        35                  40                  45
Ala Ala His Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe
    50                  55                  60
Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr
65                  70                  75                  80
Leu Arg Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr
                85                  90                  95
Lys Phe Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn
            100                 105                 110
Met Lys Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser
        115                 120                 125
Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val Gln Ala
    130                 135                 140
Leu Ala Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly
145                 150                 155                 160
Met His Thr Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn Arg Leu
                165                 170                 175
Val Gly Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser
            180                 185                 190
Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr
        195                 200                 205
Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys
    210                 215                 220
Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val
225                 230                 235                 240
Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr
                245                 250                 255
Lys


<210> 1203
<211> 481
<212> PRT
<213> Homo sapiens

<400> 1203
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Glu Phe Gln Leu Pro Ser Ser Gln Ile Ser Met Val
                85                  90                  95
Pro Asn Val Gly Leu Lys Phe Ser Ile Ser Asn Ala Asn Ile Lys Ile
            100                 105                 110
Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe Leu Lys Met Ser Gly Asn
        115                 120                 125
Phe Asp Leu Ser Ile Glu Gly Met Ser Ile Ser Ala Asp Leu Lys Leu
    130                 135                 140
Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr Ile Thr Cys Ser Ser Cys
145                 150                 155                 160
Ser Ser His Ile Asn Ser Val His Val His Ile Ser Lys Ser Lys Val
                165                 170                 175
Gly Trp Leu Ile Gln Leu Phe His Lys Lys Ile Glu Ser Ala Leu Arg
            180                 185                 190
Asn Lys Met Asn Ser Gln Val Cys Glu Lys Val Thr Asn Ser Val Ser
        195                 200                 205
Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu Pro Val Met Thr Lys Ile
    210                 215                 220
Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro Ala Thr
225                 230                 235                 240
Thr Ala Glu Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr Ser Glu
                245                 250                 255
Asn His His Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu Phe Pro
            260                 265                 270
Ala Ala His Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe
        275                 280                 285
Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr
    290                 295                 300
Leu Arg Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr
305                 310                 315                 320
Lys Phe Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn
                325                 330                 335
Met Lys Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser
            340                 345                 350
Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val Gln Ala
        355                 360                 365
Leu Ala Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly
    370                 375                 380
Met His Thr Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn Arg Leu
385                 390                 395                 400
Val Gly Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser
                405                 410                 415
Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr
            420                 425                 430
Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys
        435                 440                 445
Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val
    450                 455                 460
Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr
465                 470                 475                 480
Lys


<210> 1204
<211> 481
<212> PRT
<213> Homo sapiens

<400> 1204
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Cys
145                 150                 155                 160
Ser Ser His Ile Asn Ser Val His Val His Ile Ser Lys Ser Lys Val
                165                 170                 175
Gly Trp Leu Ile Gln Leu Phe His Lys Lys Ile Glu Ser Ala Leu Arg
            180                 185                 190
Asn Lys Met Asn Ser Gln Val Cys Glu Lys Val Thr Asn Ser Val Ser
        195                 200                 205
Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu Pro Val Met Thr Lys Ile
    210                 215                 220
Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro Ala Thr
225                 230                 235                 240
Thr Ala Glu Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr Ser Glu
                245                 250                 255
Asn His His Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu Phe Pro
            260                 265                 270
Ala Ala His Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe
        275                 280                 285
Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr
    290                 295                 300
Leu Arg Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr
305                 310                 315                 320
Lys Phe Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn
                325                 330                 335
Met Lys Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser
            340                 345                 350
Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val Gln Ala
        355                 360                 365
Leu Ala Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly
    370                 375                 380
Met His Thr Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn Arg Leu
385                 390                 395                 400
Val Gly Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser
                405                 410                 415
Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr
            420                 425                 430
Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys
        435                 440                 445
Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val
    450                 455                 460
Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr
465                 470                 475                 480
Lys


<210> 1205
<211> 479
<212> PRT
<213> Homo sapiens

<400> 1205
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Phe Gly Trp
                165                 170                 175
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190
Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp
        195                 200                 205
Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser
    210                 215                 220
Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala
225                 230                 235                 240
Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His
                245                 250                 255
Arg Ser Pro Val Thr Leu Leu Ala Ala Val Met Ser Leu Pro Glu Glu
            260                 265                 270
His Asn Lys Met Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr
        275                 280                 285
Ala Ser Leu Val Tyr His Glu Glu Gly Tyr Leu Asn Met Thr Leu Arg
    290                 295                 300
Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr Lys Phe
305                 310                 315                 320
Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn Met Lys
                325                 330                 335
Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser Val Gln
            340                 345                 350
Pro Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val Gln Ala Leu Ala
        355                 360                 365
Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly Met His
    370                 375                 380
Thr Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn Arg Leu Val Gly
385                 390                 395                 400
Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser Asn Ile
                405                 410                 415
Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr Ile Val
            420                 425                 430
Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys Gly Phe
        435                 440                 445
Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val Leu Gln
    450                 455                 460
Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr Lys
465                 470                 475

<210> 1206
<211> 481
<212> PRT
<213> Homo sapiens

<400> 1206
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Phe Gly Trp
                165                 170                 175
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190
Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp
        195                 200                 205
Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser
    210                 215                 220
Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala
225                 230                 235                 240
Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His
                245                 250                 255
Arg Ser Pro Val Thr Leu Leu Ala Ala Val Met Ser Leu Pro Glu Glu
            260                 265                 270
His Asn Lys Met Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr
        275                 280                 285
Ala Ser Leu Val Tyr His Glu Glu Gly Tyr Leu Asn Phe Ser Ile Thr
    290                 295                 300
Asp Asp Met Ile Pro Pro Asp Ser Asn Ile Arg Leu Thr Thr Lys Ser
305                 310                 315                 320
Phe Arg Pro Phe Val Pro Arg Leu Ala Arg Leu Tyr Pro Asn Met Asn
                325                 330                 335
Leu Glu Leu Gln Gly Ser Val Pro Ser Ala Pro Leu Leu Asn Phe Ser
            340                 345                 350
Pro Gly Asn Leu Ser Val Asp Pro Tyr Met Glu Ile Asp Ala Phe Val
        355                 360                 365
Leu Leu Pro Ser Ser Ser Lys Glu Pro Val Phe Arg Leu Ser Val Ala
    370                 375                 380
Met His Thr Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn Arg Leu
385                 390                 395                 400
Val Gly Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser
                405                 410                 415
Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr
            420                 425                 430
Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys
        435                 440                 445
Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val
    450                 455                 460
Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr
465                 470                 475                 480
Lys


<210> 1207
<211> 446
<212> PRT
<213> Homo sapiens

<400> 1207
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Phe Gly Trp
                165                 170                 175
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Asp Ser Val
            180                 185                 190
Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro Ala Thr Thr Ala Glu
        195                 200                 205
Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr Ser Glu Asn His His
    210                 215                 220
Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu Phe Pro Ala Ala His
225                 230                 235                 240
Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe Asn Thr Ala
                245                 250                 255
Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr Leu Arg Asp
            260                 265                 270
Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr Lys Phe Phe
        275                 280                 285
Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn Met Lys Ile
    290                 295                 300
Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser Val Gln Pro
305                 310                 315                 320
Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val Gln Ala Leu Ala Val
                325                 330                 335
Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly Met His Thr
            340                 345                 350
Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn Arg Leu Val Gly Glu
        355                 360                 365
Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser Asn Ile Gly
    370                 375                 380
Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr Ile Val Pro
385                 390                 395                 400
Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys Gly Phe Pro
                405                 410                 415
Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val Leu Gln Pro
            420                 425                 430
His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr Lys
        435                 440                 445

<210> 1208
<211> 457
<212> PRT
<213> Homo sapiens

<400> 1208
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Phe Gly Trp
                165                 170                 175
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190
Leu Glu Ser Arg Ile Cys Glu Met Asp Ser Val Ala Gly Ile Asn Tyr
        195                 200                 205
Gly Leu Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln
    210                 215                 220
Met Lys Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe
225                 230                 235                 240
Ala Pro Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr
                245                 250                 255
Leu Gly Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln
            260                 265                 270
Glu Ala Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys
        275                 280                 285
Glu Ser Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro
    290                 295                 300
Glu Val Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser
305                 310                 315                 320
Ala Ser Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe
                325                 330                 335
Tyr Pro Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser
            340                 345                 350
Leu Ala Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu
        355                 360                 365
Val Ser Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg
    370                 375                 380
Leu Leu Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu
385                 390                 395                 400
Leu Leu Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro
                405                 410                 415
Arg Val Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala
            420                 425                 430
Arg Val Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu
        435                 440                 445
Leu Phe Gly Ala Asp Val Val Tyr Lys
    450                 455

<210> 1209
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1209
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Cys Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1210
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1210
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Ala Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1211
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1211
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Ser Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1212
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1212
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Ser Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1213
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1213
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Ser Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1214
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1214
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Ala Ser Ser Ser Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Ser Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1215
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1215
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Arg Ile Pro His Val Gly Arg Gly
65                  70                  75                  80
Arg Tyr Glu Phe His Ser Leu Asn Ile His Ser Cys Glu Leu Leu His
                85                  90                  95
Ser Ala Leu Arg Pro Val Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser
            100                 105                 110
Asp Ser Ser Ile Arg Val Gln Gly Arg Trp Lys Val Arg Lys Ser Phe
        115                 120                 125
Phe Lys Leu Gln Gly Ser Phe Asp Val Ser Val Lys Gly Ile Ser Ile
    130                 135                 140
Ser Val Asn Leu Leu Leu Gly Ser Glu Ser Ser Gly Arg Pro Thr Val
145                 150                 155                 160
Thr Ala Ser Ser Cys Ser Ser Asp Ile Ala Asp Val Glu Val Asp Met
                165                 170                 175
Ser Gly Asp Phe Gly Trp Leu Leu Asn Leu Phe His Asn Gln Ile Glu
            180                 185                 190
Ser Lys Phe Gln Lys Val Leu Glu Ser Arg Ile Cys Glu Met Ile Gln
        195                 200                 205
Lys Ser Val Ser Ser Asp Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val
    210                 215                 220
Thr Thr Glu Ile Asp Ser Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1216
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1216
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Arg Ile Pro His Leu Gly Arg Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile His Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1217
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1217
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Ser Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Arg Ile Ser Gly Arg Trp Lys Ala Gln Lys Ser Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Leu Leu Gly Ser Asn Pro Thr Ser Gly Arg Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1218
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1218
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Gly Ser Asp Val Gly Trp Leu Ile Gln Leu Phe His Asn Gln
            180                 185                 190
Ile Glu Ser Ala Leu Gln Asn Val Met Asn Ser Gln Val Cys Glu Met
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Asp Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Glu Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1219
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1219
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Ser Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Arg Ile Ser Gly Arg Trp Lys Ala Gln Lys Ser Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Leu Leu Gly Ser Asn Pro Thr Ser Gly Arg Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Gly Ser Asp Val Gly Trp Leu Ile Gln Leu Phe His Asn Gln
            180                 185                 190
Ile Glu Ser Ala Leu Gln Asn Val Met Asn Ser Gln Val Cys Glu Met
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Asp Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Glu Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Leu Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1220
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1220
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1221
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1221
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1222
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1222
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1223
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1223
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1224
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1224
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1225
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1225
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1226
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1226
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1227
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1227
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1228
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1228
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1229
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1229
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1230
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1230
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1231
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1231
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1232
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1232
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1233
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1233
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1234
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1234
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1235
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1235
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1236
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1236
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1237
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1237
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1238
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1238
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1239
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1239
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1240
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1240
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val
 1               5                  10                  15
Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val
            20                  25                  30
Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala
        35                  40                  45
Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys
    50                  55                  60
Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly
65                  70                  75                  80
His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser
                85                  90                  95
Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser
            100                 105                 110
Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe
        115                 120                 125
Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile
    130                 135                 140
Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr
145                 150                 155                 160
Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His
                165                 170                 175
Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys
            180                 185                 190
Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys
        195                 200                 205
Val Thr Asn Ser Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu
    210                 215                 220
Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu
225                 230                 235                 240
Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys
                245                 250                 255
Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro
            260                 265                 270
Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly
        275                 280                 285
Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala
    290                 295                 300
Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser
305                 310                 315                 320
Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val
                325                 330                 335
Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser
            340                 345                 350
Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro
        355                 360                 365
Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala
    370                 375                 380
Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser
385                 390                 395                 400
Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu
                405                 410                 415
Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu
            420                 425                 430
Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val
        435                 440                 445
Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val
    450                 455                 460
Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe
465                 470                 475                 480
Gly Ala Asp Val Val Tyr Lys
                485

<210> 1241
<211> 483
<212> PRT
<213> Homo sapiens

<400> 1241
Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Val Ser Leu Met Val
 1               5                  10                  15
Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val Asn Pro Gly Val
            20                  25                  30
Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala Ser Gln Gln Gly
        35                  40                  45
Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys Ile Pro Asp Tyr
    50                  55                  60
Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly His Tyr Ser Phe
65                  70                  75                  80
Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser Ser Gln Ile Ser
                85                  90                  95
Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser Asn Ala Asn Ile
            100                 105                 110
Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe Leu Lys Met Ser
        115                 120                 125
Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile Ser Ala Asp Leu
    130                 135                 140
Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr Ile Thr Cys Ser
145                 150                 155                 160
Ser Cys Ser Ser His Ile Asn Ser Val His Val His Ile Ser Lys Ser
                165                 170                 175
Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys Ile Glu Ser Ala
            180                 185                 190
Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys Val Thr Asn Ser
        195                 200                 205
Val Ser Ser Lys Leu Gln Pro Tyr Phe Gln Thr Leu Pro Val Met Thr
    210                 215                 220
Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro
225                 230                 235                 240
Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr
                245                 250                 255
Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu
            260                 265                 270
Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr
        275                 280                 285
Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys
    290                 295                 300
Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu
305                 310                 315                 320
Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe
                325                 330                 335
Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser Thr Pro Pro His
            340                 345                 350
Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val
        355                 360                 365
Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu
    370                 375                 380
Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn
385                 390                 395                 400
Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys
                405                 410                 415
His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met
            420                 425                 430
Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu
        435                 440                 445
Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn
    450                 455                 460
Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val
465                 470                 475                 480
Val Tyr Lys


<210> 1242
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1242
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1243
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1243
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1244
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1244
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Leu Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1245
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1245
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1246
<211> 360
<212> PRT
<213> Homo sapiens

<400> 1246
Met Glu Asn Phe Val Ala Thr Leu Ala Asn Gly Met Ser Leu Gln Pro
 1               5                  10                  15
Pro Leu Glu Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro
            20                  25                  30
Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala
        35                  40                  45
His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu
    50                  55                  60
Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys
65                  70                  75                  80
Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala
                85                  90                  95
Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Val Cys Ser Ser Ile
            100                 105                 110
Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val
        115                 120                 125
Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu
    130                 135                 140
Lys Val Ala Ser Ser Ser Ala Ser Gly Trp Ala Thr Ala Ser Ser Thr
145                 150                 155                 160
Ser Pro Cys Ser Thr Pro Cys Ser Met Pro Gly Thr Ser Val Ala Pro
                165                 170                 175
Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala Ile
            180                 185                 190
Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn Val
        195                 200                 205
Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu Pro
    210                 215                 220
Leu Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys Leu
225                 230                 235                 240
Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr Phe
                245                 250                 255
Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His Ala
            260                 265                 270
Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg Thr
        275                 280                 285
Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln Thr
    290                 295                 300
Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu Ile
305                 310                 315                 320
Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp Leu
                325                 330                 335
Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu Ser
            340                 345                 350
Cys Ser Thr Asp Tyr Arg Met Arg
        355                 360

<210> 1247
<211> 347
<212> PRT
<213> Homo sapiens

<400> 1247
Met Val Gly Val Ala Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu
 1               5                  10                  15
Lys Pro Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser
            20                  25                  30
Tyr Ala His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg
        35                  40                  45
Thr Leu Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys
    50                  55                  60
Asp Lys Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met
65                  70                  75                  80
Phe Ala Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Val Cys Ser
                85                  90                  95
Ser Ile Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp
            100                 105                 110
His Val Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro
        115                 120                 125
Val Glu Lys Val Asp Ile Ile Ile Ser Glu Trp Met Gly Tyr Cys Leu
    130                 135                 140
Phe Tyr Glu Ser Met Leu Asn Thr Val Leu Tyr Ala Arg Asp Lys Trp
145                 150                 155                 160
Leu Ala Pro Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val
                165                 170                 175
Thr Ala Ile Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp
            180                 185                 190
Glu Asn Val Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile
        195                 200                 205
Lys Glu Pro Leu Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn
    210                 215                 220
Ala Cys Leu Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp
225                 230                 235                 240
Leu Thr Phe Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr
                245                 250                 255
Val His Ala Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His
            260                 265                 270
Lys Arg Thr Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp
        275                 280                 285
Lys Gln Thr Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly
    290                 295                 300
Glu Glu Ile Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn
305                 310                 315                 320
Arg Asp Leu Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys
                325                 330                 335
Glu Leu Ser Cys Ser Thr Asp Tyr Arg Met Arg
            340                 345

<210> 1248
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1248
Met Glu Asn Phe Val Ala Thr Leu Ala Asn Gly Met Ser Leu Gln Pro
 1               5                  10                  15
Pro Leu Glu Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro
            20                  25                  30
Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala
        35                  40                  45
His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu
    50                  55                  60
Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys
65                  70                  75                  80
Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala
                85                  90                  95
Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Val Cys Ser Ser Ile
            100                 105                 110
Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val
        115                 120                 125
Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu
    130                 135                 140
Lys Val Asp Ile Ile Ile Ser Glu Trp Met Gly Tyr Cys Leu Phe Tyr
145                 150                 155                 160
Glu Ser Met Leu Asn Thr Val Leu Tyr Ala Arg Asp Lys Trp Leu Ala
                165                 170                 175
Pro Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala
            180                 185                 190
Ile Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn
        195                 200                 205
Val Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu
    210                 215                 220
Pro Leu Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys
225                 230                 235                 240
Leu Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr
                245                 250                 255
Phe Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His
            260                 265                 270
Ala Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg
        275                 280                 285
Thr Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln
    290                 295                 300
Thr Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu
305                 310                 315                 320
Ile Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp
                325                 330                 335
Leu Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu
            340                 345                 350
Ser Cys Ser Thr Asp Tyr Arg Met Arg
        355                 360

<210> 1249
<211> 343
<212> PRT
<213> Homo sapiens

<400> 1249
Met Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro Asn Ala
 1               5                  10                  15
Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala His Phe
            20                  25                  30
Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu Thr Tyr
        35                  40                  45
Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys Val Val
    50                  55                  60
Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala Ala Lys
65                  70                  75                  80
Ala Gly Ala Arg Lys Val Ile Gly Ile Val Cys Ser Ser Ile Ser Asp
                85                  90                  95
Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val Val Thr
            100                 105                 110
Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu Lys Val
        115                 120                 125
Asp Ile Ile Ile Ser Glu Trp Met Gly Tyr Cys Leu Phe Tyr Glu Ser
    130                 135                 140
Met Leu Asn Thr Val Leu Tyr Ala Arg Asp Lys Trp Leu Ala Pro Asp
145                 150                 155                 160
Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala Ile Glu
                165                 170                 175
Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn Val Tyr
            180                 185                 190
Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu Pro Leu
        195                 200                 205
Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys Leu Ile
    210                 215                 220
Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr Phe Thr
225                 230                 235                 240
Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His Ala Leu
                245                 250                 255
Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg Thr Gly
            260                 265                 270
Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln Thr Val
        275                 280                 285
Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu Ile Phe
    290                 295                 300
Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp Leu Asp
305                 310                 315                 320
Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu Ser Cys
                325                 330                 335
Ser Thr Asp Tyr Arg Met Arg
            340

<210> 1250
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1250
Met Glu Asn Phe Val Ala Thr Leu Ala Asn Gly Met Ser Leu Gln Pro
 1               5                  10                  15
Pro Leu Glu Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro
            20                  25                  30
Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala
        35                  40                  45
His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu
    50                  55                  60
Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys
65                  70                  75                  80
Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala
                85                  90                  95
Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Glu Cys Ser Ser Ile
            100                 105                 110
Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val
        115                 120                 125
Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu
    130                 135                 140
Lys Val Asp Ile Ile Ile Ser Glu Trp Met Gly Tyr Cys Leu Phe Tyr
145                 150                 155                 160
Glu Ser Met Leu Asn Thr Val Leu Tyr Ala Arg Asp Lys Trp Leu Ala
                165                 170                 175
Pro Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala
            180                 185                 190
Ile Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn
        195                 200                 205
Val Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu
    210                 215                 220
Pro Leu Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys
225                 230                 235                 240
Leu Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr
                245                 250                 255
Phe Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His
            260                 265                 270
Ala Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg
        275                 280                 285
Thr Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln
    290                 295                 300
Thr Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu
305                 310                 315                 320
Ile Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp
                325                 330                 335
Leu Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu
            340                 345                 350
Ser Cys Ser Thr Asp Tyr Arg Met Arg
        355                 360

<210> 1251
<211> 347
<212> PRT
<213> Homo sapiens

<400> 1251
Met Val Gly Val Ala Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu
 1               5                  10                  15
Lys Pro Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser
            20                  25                  30
Tyr Ala His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg
        35                  40                  45
Thr Leu Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys
    50                  55                  60
Asp Lys Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met
65                  70                  75                  80
Phe Ala Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Glu Cys Ser
                85                  90                  95
Ser Ile Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp
            100                 105                 110
His Val Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro
        115                 120                 125
Val Glu Lys Val Asp Ile Ile Ile Ser Glu Trp Met Gly Tyr Cys Leu
    130                 135                 140
Phe Tyr Glu Ser Met Leu Asn Thr Val Leu Tyr Ala Arg Asp Lys Trp
145                 150                 155                 160
Leu Ala Pro Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val
                165                 170                 175
Thr Ala Ile Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp
            180                 185                 190
Glu Asn Val Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile
        195                 200                 205
Lys Glu Pro Leu Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn
    210                 215                 220
Ala Cys Leu Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp
225                 230                 235                 240
Leu Thr Phe Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr
                245                 250                 255
Val His Ala Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His
            260                 265                 270
Lys Arg Thr Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp
        275                 280                 285
Lys Gln Thr Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly
    290                 295                 300
Glu Glu Ile Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn
305                 310                 315                 320
Arg Asp Leu Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys
                325                 330                 335
Glu Leu Ser Cys Ser Thr Asp Tyr Arg Met Arg
            340                 345

<210> 1252
<211> 343
<212> PRT
<213> Homo sapiens

<400> 1252
Met Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro Asn Ala
 1               5                  10                  15
Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala His Phe
            20                  25                  30
Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu Thr Tyr
        35                  40                  45
Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys Val Val
    50                  55                  60
Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala Ala Lys
65                  70                  75                  80
Ala Gly Ala Arg Lys Val Ile Gly Ile Glu Cys Ser Ser Ile Ser Asp
                85                  90                  95
Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val Val Thr
            100                 105                 110
Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu Lys Val
        115                 120                 125
Asp Ile Ile Ile Ser Glu Trp Met Gly Tyr Cys Leu Phe Tyr Glu Ser
    130                 135                 140
Met Leu Asn Thr Val Leu Tyr Ala Arg Asp Lys Trp Leu Ala Pro Asp
145                 150                 155                 160
Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala Ile Glu
                165                 170                 175
Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn Val Tyr
            180                 185                 190
Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu Pro Leu
        195                 200                 205
Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys Leu Ile
    210                 215                 220
Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr Phe Thr
225                 230                 235                 240
Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His Ala Leu
                245                 250                 255
Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg Thr Gly
            260                 265                 270
Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln Thr Val
        275                 280                 285
Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu Ile Phe
    290                 295                 300
Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp Leu Asp
305                 310                 315                 320
Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu Ser Cys
                325                 330                 335
Ser Thr Asp Tyr Arg Met Arg
            340

<210> 1253
<211> 357
<212> PRT
<213> Homo sapiens

<400> 1253
Val Arg Val Lys Met Ala Ala Ala Glu Ala Ala Asn Cys Ile Met Glu
 1               5                  10                  15
Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro Asn Ala Glu Asp
            20                  25                  30
Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala His Phe Gly Ile
        35                  40                  45
His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu Thr Tyr Arg Asn
    50                  55                  60
Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys Val Val Leu Asp
65                  70                  75                  80
Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala Ala Lys Ala Gly
                85                  90                  95
Ala Arg Lys Val Ile Gly Ile Glu Cys Ser Ser Ile Ser Asp Tyr Ala
            100                 105                 110
Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val Val Thr Ile Ile
        115                 120                 125
Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu Lys Val Asp Ile
    130                 135                 140
Ile Ile Ser Glu Trp Met Gly Tyr Cys Leu Phe Tyr Glu Ser Met Leu
145                 150                 155                 160
Asn Thr Val Leu Tyr Ala Arg Asp Lys Trp Leu Ala Pro Asp Gly Leu
                165                 170                 175
Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala Ile Glu Asp Arg
            180                 185                 190
Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn Val Tyr Gly Phe
        195                 200                 205
Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu Pro Leu Val Asp
    210                 215                 220
Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys Leu Ile Lys Glu
225                 230                 235                 240
Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr Phe Thr Ser Pro
                245                 250                 255
Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His Ala Leu Val Ala
            260                 265                 270
Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg Thr Gly Phe Ser
        275                 280                 285
Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln Thr Val Phe Tyr
    290                 295                 300
Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu Ile Phe Gly Thr
305                 310                 315                 320
Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp Leu Asp Phe Thr
                325                 330                 335
Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu Ser Cys Ser Thr
            340                 345                 350
Asp Tyr Arg Met Arg
        355

<210> 1254
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1254
Met Glu Asn Phe Val Ala Thr Leu Ala Asn Gly Met Ser Leu Gln Pro
 1               5                  10                  15
Pro Leu Glu Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro
            20                  25                  30
Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala
        35                  40                  45
His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu
    50                  55                  60
Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys
65                  70                  75                  80
Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala
                85                  90                  95
Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Glu Cys Ser Ser Ile
            100                 105                 110
Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val
        115                 120                 125
Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu
    130                 135                 140
Lys Val Asp Ile Ile Ile Ser Glu Trp Met Gly Tyr Cys Leu Phe Tyr
145                 150                 155                 160
Glu Ser Met Leu Asn Thr Val Leu Tyr Ala Arg Asp Lys Trp Leu Ala
                165                 170                 175
Pro Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala
            180                 185                 190
Ile Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn
        195                 200                 205
Val Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu
    210                 215                 220
Pro Leu Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys
225                 230                 235                 240
Leu Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr
                245                 250                 255
Phe Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His
            260                 265                 270
Ala Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg
        275                 280                 285
Thr Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln
    290                 295                 300
Thr Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu
305                 310                 315                 320
Ile Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp
                325                 330                 335
Leu Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu
            340                 345                 350
Ser Cys Ser Thr Asp Tyr Arg Met Arg
        355                 360

<210> 1255
<211> 360
<212> PRT
<213> Homo sapiens

<400> 1255
Met Glu Asn Phe Val Ala Thr Leu Ala Asn Gly Met Ser Leu Gln Pro
 1               5                  10                  15
Pro Leu Glu Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro
            20                  25                  30
Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala
        35                  40                  45
His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu
    50                  55                  60
Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys
65                  70                  75                  80
Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala
                85                  90                  95
Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Val Cys Ser Ser Ile
            100                 105                 110
Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val
        115                 120                 125
Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu
    130                 135                 140
Lys Val Ala Ser Ser Ser Ala Ser Gly Trp Ala Thr Ala Ser Ser Thr
145                 150                 155                 160
Ser Pro Cys Ser Thr Pro Cys Ser Met Pro Gly Thr Ser Val Ala Pro
                165                 170                 175
Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala Ile
            180                 185                 190
Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn Val
        195                 200                 205
Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu Pro
    210                 215                 220
Leu Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys Leu
225                 230                 235                 240
Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr Phe
                245                 250                 255
Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His Ala
            260                 265                 270
Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg Thr
        275                 280                 285
Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln Thr
    290                 295                 300
Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu Ile
305                 310                 315                 320
Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp Leu
                325                 330                 335
Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu Ser
            340                 345                 350
Cys Ser Thr Asp Tyr Arg Met Arg
        355                 360

<210> 1256
<211> 360
<212> PRT
<213> Homo sapiens

<400> 1256
Met Glu Asn Phe Val Ala Thr Leu Ala Asn Gly Met Ser Leu Gln Pro
 1               5                  10                  15
Pro Leu Glu Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro
            20                  25                  30
Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala
        35                  40                  45
His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu
    50                  55                  60
Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys
65                  70                  75                  80
Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala
                85                  90                  95
Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Val Cys Ser Ser Ile
            100                 105                 110
Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val
        115                 120                 125
Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu
    130                 135                 140
Lys Val Ala Ser Ser Ser Ala Ser Gly Trp Ala Thr Ala Ser Ser Thr
145                 150                 155                 160
Ser Pro Cys Ser Thr Pro Cys Ser Met Pro Gly Thr Ser Val Ala Pro
                165                 170                 175
Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala Ile
            180                 185                 190
Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn Val
        195                 200                 205
Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu Pro
    210                 215                 220
Leu Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys Leu
225                 230                 235                 240
Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr Phe
                245                 250                 255
Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His Ala
            260                 265                 270
Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg Thr
        275                 280                 285
Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln Thr
    290                 295                 300
Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu Ile
305                 310                 315                 320
Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp Leu
                325                 330                 335
Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu Ser
            340                 345                 350
Cys Ser Thr Asp Tyr Arg Met Arg
        355                 360

<210> 1257
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1257
Met Glu Asn Phe Val Ala Thr Leu Ala Asn Gly Met Ser Leu Gln Pro
 1               5                  10                  15
Pro Leu Glu Glu Val Ser Cys Gly Gln Ala Glu Ser Ser Glu Lys Pro
            20                  25                  30
Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe Asp Ser Tyr Ala
        35                  40                  45
His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu Val Arg Thr Leu
    50                  55                  60
Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu Phe Lys Asp Lys
65                  70                  75                  80
Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu Cys Met Phe Ala
                85                  90                  95
Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Val Cys Ser Ser Ile
            100                 105                 110
Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys Leu Asp His Val
        115                 120                 125
Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu Leu Pro Val Glu
    130                 135                 140
Lys Val Asp Ile Ile Ile Ser Glu Trp Met Gly Tyr Cys Leu Phe Tyr
145                 150                 155                 160
Glu Ser Met Leu Asn Thr Val Leu Tyr Ala Arg Asp Lys Trp Leu Ala
                165                 170                 175
Pro Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu Tyr Val Thr Ala
            180                 185                 190
Ile Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His Trp Trp Glu Asn
        195                 200                 205
Val Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val Ala Ile Lys Glu
    210                 215                 220
Pro Leu Val Asp Val Val Asp Pro Lys Gln Leu Val Thr Asn Ala Cys
225                 230                 235                 240
Leu Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val Glu Asp Leu Thr
                245                 250                 255
Phe Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn Asp Tyr Val His
            260                 265                 270
Ala Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg Cys His Lys Arg
        275                 280                 285
Thr Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr His Trp Lys Gln
    290                 295                 300
Thr Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys Thr Gly Glu Glu
305                 310                 315                 320
Ile Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys Asn Asn Arg Asp
                325                 330                 335
Leu Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln Leu Cys Glu Leu
            340                 345                 350
Ser Cys Ser Thr Asp Tyr Arg Met Arg
        355                 360

<210> 1258
<211> 272
<212> PRT
<213> Homo sapiens

<400> 1258
Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu
 1               5                  10                  15
Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala
            20                  25                  30
Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile
        35                  40                  45
Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro
    50                  55                  60
Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr
65                  70                  75                  80
Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe
                85                  90                  95
Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu
            100                 105                 110
Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys
        115                 120                 125
Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu
    130                 135                 140
Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr
145                 150                 155                 160
Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly
                165                 170                 175
Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu
            180                 185                 190
Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys
        195                 200                 205
Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile
    210                 215                 220
Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys
225                 230                 235                 240
Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn
                245                 250                 255
Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln
            260                 265                 270

<210> 1259
<211> 272
<212> PRT
<213> Homo sapiens

<400> 1259
Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu
 1               5                  10                  15
Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala
            20                  25                  30
Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile
        35                  40                  45
Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro
    50                  55                  60
Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr
65                  70                  75                  80
Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe
                85                  90                  95
Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu
            100                 105                 110
Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys
        115                 120                 125
Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu
    130                 135                 140
Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr
145                 150                 155                 160
Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly
                165                 170                 175
Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu
            180                 185                 190
Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys
        195                 200                 205
Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile
    210                 215                 220
Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys
225                 230                 235                 240
Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn
                245                 250                 255
Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln
            260                 265                 270

<210> 1260
<211> 279
<212> PRT
<213> Homo sapiens

<400> 1260
Glu Gly Pro Ala Glu Gly Asn Met Ala Ala Lys Val Phe Glu Ser Ile
 1               5                  10                  15
Gly Lys Phe Gly Leu Ala Leu Ala Val Ala Gly Gly Val Val Asn Ser
            20                  25                  30
Ala Leu Tyr Asn Val Asp Ala Gly His Arg Ala Val Ile Phe Asp Arg
        35                  40                  45
Phe Arg Gly Val Gln Asp Ile Val Val Gly Glu Gly Thr His Phe Leu
    50                  55                  60
Ile Pro Trp Val Gln Lys Pro Ile Ile Phe Asp Cys Arg Ser Arg Pro
65                  70                  75                  80
Arg Asn Val Pro Val Ile Thr Gly Ser Lys Asp Leu Gln Asn Val Asn
                85                  90                  95
Ile Thr Leu Arg Ile Leu Phe Arg Pro Val Ala Ser Gln Leu Pro Arg
            100                 105                 110
Ile Phe Thr Ser Ile Gly Glu Asp Tyr Asp Glu Arg Val Leu Pro Ser
        115                 120                 125
Ile Thr Thr Glu Ile Leu Lys Ser Val Val Ala Arg Phe Asp Ala Gly
    130                 135                 140
Glu Leu Ile Thr Gln Arg Glu Leu Val Ser Arg Gln Val Ser Asp Asp
145                 150                 155                 160
Leu Thr Glu Arg Ala Ala Thr Phe Gly Leu Ile Leu Asp Asp Val Ser
                165                 170                 175
Leu Thr His Leu Thr Phe Gly Lys Glu Phe Thr Glu Ala Val Glu Ala
            180                 185                 190
Lys Gln Val Ala Gln Gln Glu Ala Glu Arg Ala Arg Phe Val Val Glu
        195                 200                 205
Lys Ala Glu Gln Gln Lys Lys Ala Ala Ile Ile Ser Ala Glu Gly Asp
    210                 215                 220
Ser Lys Ala Ala Glu Leu Ile Ala Asn Ser Leu Ala Thr Ala Gly Asp
225                 230                 235                 240
Gly Leu Ile Glu Leu Arg Lys Leu Glu Ala Ala Glu Asp Ile Ala Tyr
                245                 250                 255
Gln Leu Ser Arg Ser Arg Asn Ile Thr Tyr Leu Pro Ala Gly Gln Ser
            260                 265                 270
Val Leu Leu Gln Leu Pro Gln
        275

<210> 1261
<211> 279
<212> PRT
<213> Homo sapiens

<400> 1261
Glu Gly Pro Ala Glu Gly Asn Met Ala Ala Lys Val Phe Glu Ser Ile
 1               5                  10                  15
Gly Lys Phe Gly Leu Ala Leu Ala Val Ala Gly Gly Val Val Asn Ser
            20                  25                  30
Ala Leu Tyr Asn Val Asp Ala Gly His Arg Ala Val Ile Phe Asp Arg
        35                  40                  45
Phe Arg Gly Val Gln Asp Ile Val Val Gly Glu Gly Thr His Phe Leu
    50                  55                  60
Ile Pro Trp Val Gln Lys Pro Ile Ile Phe Asp Cys Arg Ser Arg Pro
65                  70                  75                  80
Arg Asn Val Pro Val Ile Thr Gly Ser Lys Asp Leu Gln Asn Val Asn
                85                  90                  95
Ile Thr Leu Arg Ile Leu Phe Arg Pro Val Ala Ser Gln Leu Pro Arg
            100                 105                 110
Ile Phe Thr Ser Ile Gly Glu Asp Tyr Asp Glu Arg Val Leu Pro Ser
        115                 120                 125
Ile Thr Thr Glu Ile Leu Lys Ser Val Val Ala Arg Phe Asp Ala Gly
    130                 135                 140
Glu Leu Ile Thr Gln Arg Glu Leu Val Ser Arg Gln Val Ser Asp Asp
145                 150                 155                 160
Leu Thr Glu Arg Ala Ala Thr Phe Gly Leu Ile Leu Asp Asp Val Ser
                165                 170                 175
Leu Thr His Leu Thr Phe Gly Lys Glu Phe Thr Glu Ala Val Glu Ala
            180                 185                 190
Lys Gln Val Ala Gln Gln Glu Ala Glu Arg Ala Arg Phe Val Val Glu
        195                 200                 205
Lys Ala Glu Gln Gln Lys Lys Ala Ala Ile Ile Ser Ala Glu Gly Asp
    210                 215                 220
Ser Lys Ala Ala Glu Leu Ile Ala Asn Ser Leu Ala Thr Ala Gly Asp
225                 230                 235                 240
Gly Leu Ile Glu Leu Arg Lys Leu Glu Ala Ala Glu Asp Ile Ala Tyr
                245                 250                 255
Gln Leu Ser Arg Ser Arg Asn Ile Thr Tyr Leu Pro Ala Gly Gln Ser
            260                 265                 270
Val Leu Leu Gln Leu Pro Gln
        275

<210> 1262
<211> 198
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(198)
<223> Xaa = Any Amino Acid

<400> 1262
Ala Ile Val Val Gly Xaa Gly Thr His Phe Leu Ile Pro Trp Val Gln
 1               5                  10                  15
Lys Pro Ile Ile Phe Asp His Arg Ser Gln Pro His Asn Val Pro Val
            20                  25                  30
Ile Thr Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Ile Pro Cys Ile
        35                  40                  45
Leu Phe Gly Pro Val Thr Ser Gln Leu Pro Arg Ile Phe Thr Arg Ile
    50                  55                  60
Gly Glu Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile
65                  70                  75                  80
Leu Lys Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln
                85                  90                  95
Arg Glu Leu Val Ser Arg Gln Val Ser Asp Asp Leu Met Glu Arg Ala
            100                 105                 110
Ala Thr Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr
        115                 120                 125
Phe Arg Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln
    130                 135                 140
Gln Asp Ala Glu Arg Ala Arg Asn Ser Leu Ala Thr Ala Gly Asp Gly
145                 150                 155                 160
Leu Met Glu Leu Cys Lys Leu Glu Ala Ala Glu Asp Ile Thr Tyr Gln
                165                 170                 175
Leu Ser Arg Ser Trp Asn Ile Thr Asn Leu Pro Ala Gly Gln Ser Val
            180                 185                 190
Leu Leu Gln Leu Pro Gln
        195

<210> 1263
<211> 272
<212> PRT
<213> Homo sapiens

<400> 1263
Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu
 1               5                  10                  15
Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala
            20                  25                  30
Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile
        35                  40                  45
Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro
    50                  55                  60
Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr
65                  70                  75                  80
Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe
                85                  90                  95
Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu
            100                 105                 110
Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys
        115                 120                 125
Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu
    130                 135                 140
Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr
145                 150                 155                 160
Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly
                165                 170                 175
Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu
            180                 185                 190
Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys
        195                 200                 205
Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile
    210                 215                 220
Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys
225                 230                 235                 240
Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn
                245                 250                 255
Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln
            260                 265                 270

<210> 1264
<211> 297
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(297)
<223> Xaa = Any Amino Acid

<400> 1264
Asn Phe Arg Val Glu Ala Gly Val Arg Gly Val Gln Gln Lys Glu Thr
 1               5                  10                  15
Cys Ala Phe Lys Val Leu Glu Ser Ile Gly Lys Leu Gly Leu Ala Leu
            20                  25                  30
Ser Val Ala Gly Gly Ala Glu Asn Ser Ala Leu Tyr Asn Val Asp Ala
        35                  40                  45
Gly His Arg Ala Val Ile Phe Asp Pro Ile Pro Gly Gln Lys Xaa Gln
    50                  55                  60
Asp Ile Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln
65                  70                  75                  80
Lys Pro Gln Leu Ser Asn Asp Cys Arg Ser Arg Pro Arg Asn Cys Cys
                85                  90                  95
Gln Ser Ile Thr Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu
            100                 105                 110
Arg His Pro Ser Ser Gly Pro Val Arg Gln Pro Ser Phe Pro Arg Ile
        115                 120                 125
Phe Thr Ser Ile Gly Glu Asp Tyr Asp Glu Arg Val Leu Ala Val Pro
    130                 135                 140
Ser Gln Leu Glu Asn Leu Lys Ser Val Val Ala Pro Phe Asp Ala Gly
145                 150                 155                 160
Glu Leu Ile Thr Gln Arg Glu Leu Val Ser Arg Gln Val Ser Asp Asp
                165                 170                 175
Leu Thr Glu Arg Ala Ala Thr Phe Gly Leu Ile Leu Asp Asp Val Ser
            180                 185                 190
Leu Thr His Leu Thr Phe Gly Lys Leu Leu Thr Glu Ala Val Glu Ala
        195                 200                 205
Lys Gln Val Ala Gln Gln Gly Lys Gln Arg Arg Ala Arg Phe Val Val
    210                 215                 220
Leu Glu Lys Ala Glu Gln Gln Lys Lys Ala Ala Ile Ile Ser Ala Glu
225                 230                 235                 240
Gly Asp Ser Lys Ala Ala Glu Leu Ile Ala Asn Ser Leu Ala Thr Ala
                245                 250                 255
Gly Asp Gly Leu Ile Glu Leu Arg Lys Leu Glu Ala Ala Glu Asp Ile
            260                 265                 270
Ala Tyr Gln Leu Ser Arg Ser Arg Asn Ile Thr Tyr Leu Pro Ala Gly
        275                 280                 285
Gln Ser Val Leu Leu Gln Leu Pro Gln
    290                 295

<210> 1265
<211> 471
<212> PRT
<213> Homo sapiens

<400> 1265
Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp
 1               5                  10                  15
Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala
            20                  25                  30
Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly
        35                  40                  45
Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu
    50                  55                  60
Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln
65                  70                  75                  80
Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg
                85                  90                  95
Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys
            100                 105                 110
Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln
        115                 120                 125
Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu
    130                 135                 140
Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu
145                 150                 155                 160
Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser
                165                 170                 175
Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly
            180                 185                 190
Gly Arg Ser Cys Lys Ile Arg Met Ala Ala Lys Val Phe Glu Ser Ile
        195                 200                 205
Gly Lys Phe Gly Leu Ala Leu Ala Val Ala Gly Gly Val Val Asn Ser
    210                 215                 220
Ala Leu Tyr Asn Val Asp Ala Gly His Arg Ala Val Ile Phe Asp Arg
225                 230                 235                 240
Phe Arg Gly Val Gln Asp Ile Val Val Gly Glu Gly Thr His Phe Leu
                245                 250                 255
Ile Pro Trp Val Gln Lys Pro Ile Ile Phe Asp Cys Arg Ser Arg Pro
            260                 265                 270
Arg Asn Val Pro Val Ile Thr Gly Ser Lys Asp Leu Gln Asn Val Asn
        275                 280                 285
Ile Thr Leu Arg Ile Leu Phe Arg Pro Val Ala Ser Gln Leu Pro Arg
    290                 295                 300
Ile Phe Thr Ser Ile Gly Glu Asp Tyr Asp Glu Arg Val Leu Pro Ser
305                 310                 315                 320
Ile Thr Thr Glu Ile Leu Lys Ser Val Val Ala Arg Phe Asp Ala Gly
                325                 330                 335
Glu Leu Ile Thr Gln Arg Glu Leu Val Ser Arg Gln Val Ser Asp Asp
            340                 345                 350
Leu Thr Glu Arg Ala Ala Thr Phe Gly Leu Ile Leu Asp Asp Val Ser
        355                 360                 365
Leu Thr His Leu Thr Phe Gly Lys Glu Phe Thr Glu Ala Val Glu Ala
    370                 375                 380
Lys Gln Val Ala Gln Gln Glu Ala Glu Arg Ala Arg Phe Val Val Glu
385                 390                 395                 400
Lys Ala Glu Gln Gln Lys Lys Ala Ala Ile Ile Ser Ala Glu Gly Asp
                405                 410                 415
Ser Lys Ala Ala Glu Leu Ile Ala Asn Ser Leu Ala Thr Ala Gly Asp
            420                 425                 430
Gly Leu Ile Glu Leu Arg Lys Leu Glu Ala Ala Glu Asp Ile Ala Tyr
        435                 440                 445
Gln Leu Ser Arg Ser Arg Asn Ile Thr Tyr Leu Pro Ala Gly Gln Ser
    450                 455                 460
Val Leu Leu Gln Leu Pro Gln
465                 470

<210> 1266
<211> 272
<212> PRT
<213> Homo sapiens

<400> 1266
Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu
 1               5                  10                  15
Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala
            20                  25                  30
Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile
        35                  40                  45
Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro
    50                  55                  60
Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr
65                  70                  75                  80
Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe
                85                  90                  95
Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu
            100                 105                 110
Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys
        115                 120                 125
Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu
    130                 135                 140
Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr
145                 150                 155                 160
Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly
                165                 170                 175
Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu
            180                 185                 190
Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys
        195                 200                 205
Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile
    210                 215                 220
Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys
225                 230                 235                 240
Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn
                245                 250                 255
Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln
            260                 265                 270

<210> 1267
<211> 272
<212> PRT
<213> Homo sapiens

<400> 1267
Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu
 1               5                  10                  15
Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala
            20                  25                  30
Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile
        35                  40                  45
Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro
    50                  55                  60
Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr
65                  70                  75                  80
Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe
                85                  90                  95
Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu
            100                 105                 110
Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys
        115                 120                 125
Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu
    130                 135                 140
Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr
145                 150                 155                 160
Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly
                165                 170                 175
Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu
            180                 185                 190
Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys
        195                 200                 205
Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile
    210                 215                 220
Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys
225                 230                 235                 240
Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn
                245                 250                 255
Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln
            260                 265                 270

<210> 1268
<211> 676
<212> PRT
<213> Homo sapiens

<400> 1268
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Ser Thr Ser Ser Asn Thr Ile Ser Ala
        195                 200                 205
Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu
    210                 215                 220
Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser
225                 230                 235                 240
Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln Asn Gln
                245                 250                 255
Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu
            260                 265                 270
Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr Thr Ala
        275                 280                 285
Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile His His
    290                 295                 300
Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr Ile Gln
305                 310                 315                 320
Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys Glu Gln
                325                 330                 335
Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro Lys Glu
            340                 345                 350
Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His Thr Ser
        355                 360                 365
His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser Ser Trp
    370                 375                 380
Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly His Gln
385                 390                 395                 400
Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr Leu Gln
                405                 410                 415
Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr
            420                 425                 430
Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser
        435                 440                 445
Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr Thr Ser
    450                 455                 460
Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg Arg Asp
465                 470                 475                 480
Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser
                485                 490                 495
His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val Thr Ser
            500                 505                 510
Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser
        515                 520                 525
Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His
    530                 535                 540
Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His
545                 550                 555                 560
Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile
                565                 570                 575
Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu
            580                 585                 590
Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg
        595                 600                 605
Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala
    610                 615                 620
Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser
625                 630                 635                 640
Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp
                645                 650                 655
Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met
            660                 665                 670
Lys Ile Gly Val
        675

<210> 1269
<211> 470
<212> PRT
<213> Homo sapiens

<400> 1269
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Asn Met Asp Ser Ser His Ser Ile Thr
        195                 200                 205
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp
    210                 215                 220
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser
225                 230                 235                 240
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr
                245                 250                 255
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg
            260                 265                 270
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr
        275                 280                 285
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val
    290                 295                 300
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly
305                 310                 315                 320
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr
                325                 330                 335
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp
            340                 345                 350
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly
        355                 360                 365
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser
    370                 375                 380
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser
385                 390                 395                 400
Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn
                405                 410                 415
Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser
            420                 425                 430
Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr
        435                 440                 445
Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val
    450                 455                 460
Asp Met Lys Ile Gly Val
465                 470

<210> 1270
<211> 719
<212> PRT
<213> Homo sapiens

<400> 1270
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Thr Leu Met Ser Thr Ser Ala Thr Ala
        195                 200                 205
Thr Glu Thr Ala Thr Lys Arg Gln Glu Thr Trp Asp Trp Phe Ser Trp
    210                 215                 220
Leu Phe Leu Pro Ser Glu Ser Lys Asn His Leu His Thr Thr Thr Gln
225                 230                 235                 240
Met Ala Gly Thr Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn
                245                 250                 255
Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser
            260                 265                 270
Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr
        275                 280                 285
Pro Arg Ala Phe Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp
    290                 295                 300
Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg
305                 310                 315                 320
Met Thr Asp Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp
                325                 330                 335
Asn Pro Glu Ala His Pro Pro Leu Ile His His Glu His His Glu Glu
            340                 345                 350
Glu Glu Thr Pro His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser
        355                 360                 365
Thr Thr Glu Glu Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg
    370                 375                 380
Trp His Glu Gly Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr
385                 390                 395                 400
Thr Gly Thr Ala Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly
                405                 410                 415
Arg Thr Thr Pro Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn
            420                 425                 430
Pro Ile Ser His Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met
        435                 440                 445
Asp Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro
    450                 455                 460
Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met
465                 470                 475                 480
Thr Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly
                485                 490                 495
Leu Glu Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser
            500                 505                 510
Asn Arg Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu
        515                 520                 525
Gly Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr
    530                 535                 540
Lys Glu Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser
545                 550                 555                 560
Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn
                565                 570                 575
Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser
            580                 585                 590
His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln
        595                 600                 605
Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile
    610                 615                 620
Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile
625                 630                 635                 640
Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys
                645                 650                 655
Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys
            660                 665                 670
Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His
        675                 680                 685
Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala
    690                 695                 700
Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
705                 710                 715

<210> 1271
<211> 338
<212> PRT
<213> Homo sapiens

<400> 1271
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Arg Asp Gln Asp Thr Phe His Pro Ser
        195                 200                 205
Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His
    210                 215                 220
Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr
225                 230                 235                 240
Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu
                245                 250                 255
Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys
            260                 265                 270
Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu
        275                 280                 285
Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu
    290                 295                 300
Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe
305                 310                 315                 320
Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile
                325                 330                 335
Gly Val


<210> 1272
<211> 271
<212> PRT
<213> Homo sapiens

<400> 1272
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Arg Asp Gln Asp Thr Phe His Pro Ser
        195                 200                 205
Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His
    210                 215                 220
Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr
225                 230                 235                 240
Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu
                245                 250                 255
Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Ser
            260                 265                 270

<210> 1273
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1273
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Met Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1274
<211> 699
<212> PRT
<213> Homo sapiens

<400> 1274
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr
    210                 215                 220
Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu
225                 230                 235                 240
Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp
                245                 250                 255
Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe
            260                 265                 270
Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His
        275                 280                 285
Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val
    290                 295                 300
Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala
305                 310                 315                 320
His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro
                325                 330                 335
His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu
            340                 345                 350
Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly
        355                 360                 365
Tyr Arg Gln Thr Pro Arg Glu Asp Ser His Ser Thr Thr Gly Thr Ala
    370                 375                 380
Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro
385                 390                 395                 400
Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His
                405                 410                 415
Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser
            420                 425                 430
Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu
        435                 440                 445
Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln
    450                 455                 460
Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp
465                 470                 475                 480
Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp
                485                 490                 495
Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr
            500                 505                 510
Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg
        515                 520                 525
Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr
    530                 535                 540
Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser
545                 550                 555                 560
Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His
                565                 570                 575
Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala
            580                 585                 590
Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu
        595                 600                 605
Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys
    610                 615                 620
Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val
625                 630                 635                 640
Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu
                645                 650                 655
Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys
            660                 665                 670
Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg
        675                 680                 685
Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
    690                 695

<210> 1275
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1275
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1276
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1276
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Glu Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1277
<211> 293
<212> PRT
<213> Homo sapiens

<400> 1277
Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro Leu
 1               5                  10                  15
Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly Val
            20                  25                  30
Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala
        35                  40                  45
Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala Gln
    50                  55                  60
Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe
65                  70                  75                  80
Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile Cys
                85                  90                  95
Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln
            100                 105                 110
Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys
        115                 120                 125
Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile
    130                 135                 140
Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr
145                 150                 155                 160
Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp
                165                 170                 175
Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr
            180                 185                 190
Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp Ser
        195                 200                 205
Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp Gln
    210                 215                 220
Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu
225                 230                 235                 240
Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr
                245                 250                 255
Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu
            260                 265                 270
Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val
        275                 280                 285
Asn Ser Arg Arg Ser
    290

<210> 1278
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1278
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg
        275                 280                 285
Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser
    290                 295                 300
Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu
305                 310                 315                 320
Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly
                325                 330                 335
Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser
            340                 345                 350
Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr
        355                 360                 365
Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly
    370                 375                 380
Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu
385                 390                 395                 400
Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala
                405                 410                 415
Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys
            420                 425                 430
Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser
        435                 440                 445
Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val
    450                 455                 460
Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu
465                 470                 475                 480
Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
                485                 490

<210> 1279
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1279
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Arg Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg
        275                 280                 285
Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser
    290                 295                 300
Thr His Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu
305                 310                 315                 320
Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly
                325                 330                 335
Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser
            340                 345                 350
Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr
        355                 360                 365
Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly
    370                 375                 380
Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu
385                 390                 395                 400
Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala
                405                 410                 415
Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys
            420                 425                 430
Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser
        435                 440                 445
Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val
    450                 455                 460
Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu
465                 470                 475                 480
Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
                485                 490

<210> 1280
<211> 699
<212> PRT
<213> Homo sapiens

<400> 1280
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr
    210                 215                 220
Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu
225                 230                 235                 240
Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp
                245                 250                 255
Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe
            260                 265                 270
Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His
        275                 280                 285
Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val
    290                 295                 300
Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala
305                 310                 315                 320
His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro
                325                 330                 335
His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu
            340                 345                 350
Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Val Gly
        355                 360                 365
Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala
    370                 375                 380
Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro
385                 390                 395                 400
Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His
                405                 410                 415
Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser
            420                 425                 430
Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu
        435                 440                 445
Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln
    450                 455                 460
Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp
465                 470                 475                 480
Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp
                485                 490                 495
Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr
            500                 505                 510
Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg
        515                 520                 525
Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr
    530                 535                 540
Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser
545                 550                 555                 560
Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His
                565                 570                 575
Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala
            580                 585                 590
Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu
        595                 600                 605
Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys
    610                 615                 620
Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val
625                 630                 635                 640
Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu
                645                 650                 655
Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys
            660                 665                 670
Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg
        675                 680                 685
Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
    690                 695

<210> 1281
<211> 395
<212> PRT
<213> Homo sapiens

<400> 1281
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Arg Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His
            260                 265                 270
Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala
        275                 280                 285
Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu
    290                 295                 300
Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys
305                 310                 315                 320
Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val
                325                 330                 335
Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu
            340                 345                 350
Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys
        355                 360                 365
Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg
    370                 375                 380
Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
385                 390                 395

<210> 1282
<211> 742
<212> PRT
<213> Homo sapiens

<400> 1282
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu
    210                 215                 220
Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu
225                 230                 235                 240
Ala Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn
                245                 250                 255
His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile
            260                 265                 270
Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg
        275                 280                 285
His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile
    290                 295                 300
Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln
305                 310                 315                 320
Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val
                325                 330                 335
Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr
            340                 345                 350
Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile
        355                 360                 365
His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr
    370                 375                 380
Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys
385                 390                 395                 400
Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro
                405                 410                 415
Arg Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His
            420                 425                 430
Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser
        435                 440                 445
Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly
    450                 455                 460
His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Thr Thr
465                 470                 475                 480
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asn Leu Asp
                485                 490                 495
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser
            500                 505                 510
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr
        515                 520                 525
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg
    530                 535                 540
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr
545                 550                 555                 560
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val
                565                 570                 575
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly
            580                 585                 590
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr
        595                 600                 605
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp
    610                 615                 620
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly
625                 630                 635                 640
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser
                645                 650                 655
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser
            660                 665                 670
Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn
        675                 680                 685
Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser
    690                 695                 700
Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr
705                 710                 715                 720
Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val
                725                 730                 735
Asp Met Lys Ile Gly Val
            740

<210> 1283
<211> 425
<212> PRT
<213> Homo sapiens

<400> 1283
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Arg Asp
        275                 280                 285
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
    290                 295                 300
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
305                 310                 315                 320
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
                325                 330                 335
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
            340                 345                 350
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
        355                 360                 365
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
    370                 375                 380
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
385                 390                 395                 400
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
                405                 410                 415
Gln Asn Val Asp Met Lys Ile Gly Val
            420                 425

<210> 1284
<211> 675
<212> PRT
<213> Homo sapiens

<400> 1284
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu
    210                 215                 220
Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu
225                 230                 235                 240
Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn
                245                 250                 255
His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile
            260                 265                 270
Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg
        275                 280                 285
His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile
    290                 295                 300
Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln
305                 310                 315                 320
Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val
                325                 330                 335
Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr
            340                 345                 350
Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile
        355                 360                 365
His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr
    370                 375                 380
Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys
385                 390                 395                 400
Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro
                405                 410                 415
Arg Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His
            420                 425                 430
Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser
        435                 440                 445
Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly
    450                 455                 460
His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Thr Thr
465                 470                 475                 480
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp
                485                 490                 495
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser
            500                 505                 510
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr
        515                 520                 525
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg
    530                 535                 540
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr
545                 550                 555                 560
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val
                565                 570                 575
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly
            580                 585                 590
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr
        595                 600                 605
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp
    610                 615                 620
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly
625                 630                 635                 640
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser
                645                 650                 655
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser
            660                 665                 670
Arg Arg Ser
        675

<210> 1285
<211> 668
<212> PRT
<213> Homo sapiens

<400> 1285
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Ala
            180                 185                 190
Leu Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln
        195                 200                 205
Glu Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys
    210                 215                 220
Asn His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr
225                 230                 235                 240
Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp
                245                 250                 255
Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe
            260                 265                 270
Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys
        275                 280                 285
Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu
    290                 295                 300
Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly
305                 310                 315                 320
Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu
                325                 330                 335
Ile His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser
            340                 345                 350
Thr Thr Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr
        355                 360                 365
Pro Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser
    370                 375                 380
His Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp
385                 390                 395                 400
Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly
                405                 410                 415
Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln
            420                 425                 430
Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu
        435                 440                 445
Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn
    450                 455                 460
Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr
465                 470                 475                 480
Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser
                485                 490                 495
Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val
            500                 505                 510
Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu
        515                 520                 525
Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr
    530                 535                 540
His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly
545                 550                 555                 560
Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp
                565                 570                 575
Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val
            580                 585                 590
Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu
        595                 600                 605
Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly
    610                 615                 620
Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn
625                 630                 635                 640
Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr
                645                 650                 655
Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
            660                 665

<210> 1286
<211> 742
<212> PRT
<213> Homo sapiens

<400> 1286
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu
    210                 215                 220
Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu
225                 230                 235                 240
Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn
                245                 250                 255
His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile
            260                 265                 270
Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg
        275                 280                 285
His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile
    290                 295                 300
Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln
305                 310                 315                 320
Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val
                325                 330                 335
Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr
            340                 345                 350
Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile
        355                 360                 365
His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr
    370                 375                 380
Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys
385                 390                 395                 400
Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro
                405                 410                 415
Arg Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His
            420                 425                 430
Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser
        435                 440                 445
Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly
    450                 455                 460
His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Thr Thr
465                 470                 475                 480
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp
                485                 490                 495
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser
            500                 505                 510
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr
        515                 520                 525
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg
    530                 535                 540
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr
545                 550                 555                 560
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val
                565                 570                 575
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly
            580                 585                 590
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr
        595                 600                 605
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp
    610                 615                 620
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly
625                 630                 635                 640
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser
                645                 650                 655
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser
            660                 665                 670
Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn
        675                 680                 685
Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser
    690                 695                 700
Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr
705                 710                 715                 720
Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val
                725                 730                 735
Asp Met Lys Ile Gly Val
            740

<210> 1287
<211> 691
<212> PRT
<213> Homo sapiens

<400> 1287
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu
    210                 215                 220
Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu
225                 230                 235                 240
Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn
                245                 250                 255
His Leu His Thr Thr Thr Gln Met Ala Ala Gly Trp Glu Pro Asn Glu
            260                 265                 270
Glu Asn Glu Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly
        275                 280                 285
Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro
    290                 295                 300
Arg Ala Phe Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn
305                 310                 315                 320
Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met
                325                 330                 335
Thr Asp Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn
            340                 345                 350
Pro Glu Ala His Pro Pro Leu Ile His His Glu His His Glu Glu Glu
        355                 360                 365
Glu Thr Pro His Ser Thr Ser Thr Thr Ala Ser Ala His Thr Ser His
    370                 375                 380
Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser Ser Trp Thr
385                 390                 395                 400
Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly His Gln Ala
                405                 410                 415
Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Thr Thr Leu Gln Pro
            420                 425                 430
Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly
        435                 440                 445
Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr
    450                 455                 460
Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr Thr Ser Thr
465                 470                 475                 480
Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg Arg Asp Pro
                485                 490                 495
Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser His
            500                 505                 510
Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val Thr Ser Ala
        515                 520                 525
Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser Asn
    530                 535                 540
Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His Pro
545                 550                 555                 560
Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser
                565                 570                 575
His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg
            580                 585                 590
Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala
        595                 600                 605
Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg
    610                 615                 620
Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val
625                 630                 635                 640
Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln
                645                 650                 655
Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln
            660                 665                 670
Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys
        675                 680                 685
Ile Gly Val
    690

<210> 1288
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1288
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1289
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1289
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg
        275                 280                 285
Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser
    290                 295                 300
Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu
305                 310                 315                 320
Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly
                325                 330                 335
Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser
            340                 345                 350
Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr
        355                 360                 365
Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly
    370                 375                 380
Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu
385                 390                 395                 400
Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala
                405                 410                 415
Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys
            420                 425                 430
Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser
        435                 440                 445
Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val
    450                 455                 460
Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu
465                 470                 475                 480
Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
                485                 490

<210> 1290
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1290
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Ser
    290

<210> 1291
<211> 95
<212> PRT
<213> Homo sapiens

<400> 1291
Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro Leu Ser
 1               5                  10                  15
Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe
            20                  25                  30
His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala
        35                  40                  45
Asp Leu Cys Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile
    50                  55                  60
His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu
65                  70                  75                  80
Thr Tyr Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser
                85                  90                  95

<210> 1292
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1292
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Glu Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1293
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1293
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Arg Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg
        275                 280                 285
Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser
    290                 295                 300
Thr His Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu
305                 310                 315                 320
Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly
                325                 330                 335
Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser
            340                 345                 350
Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr
        355                 360                 365
Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly
    370                 375                 380
Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu
385                 390                 395                 400
Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala
                405                 410                 415
Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys
            420                 425                 430
Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser
        435                 440                 445
Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val
    450                 455                 460
Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu
465                 470                 475                 480
Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
                485                 490

<210> 1294
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1294
Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His
 1               5                  10                  15
Pro Asn Ser Ile Cys
            20

<210> 1295
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1295
Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro
 1               5                  10                  15
Asn Ser Ile


<210> 1296
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1296
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Glu Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1297
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1297
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Arg Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg
        275                 280                 285
Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser
    290                 295                 300
Thr His Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu
305                 310                 315                 320
Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly
                325                 330                 335
Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser
            340                 345                 350
Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr
        355                 360                 365
Thr Arg Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly
    370                 375                 380
Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu
385                 390                 395                 400
Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala
                405                 410                 415
Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys
            420                 425                 430
Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser
        435                 440                 445
Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val
    450                 455                 460
Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu
465                 470                 475                 480
Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
                485                 490

<210> 1298
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1298
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Glu Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1299
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1299
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Arg Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg
        275                 280                 285
Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser
    290                 295                 300
Thr His Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu
305                 310                 315                 320
Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly
                325                 330                 335
Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser
            340                 345                 350
Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr
        355                 360                 365
Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly
    370                 375                 380
Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu
385                 390                 395                 400
Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala
                405                 410                 415
Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys
            420                 425                 430
Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser
        435                 440                 445
Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val
    450                 455                 460
Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu
465                 470                 475                 480
Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
                485                 490

<210> 1300
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1300
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Glu Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1301
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1301
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Arg Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg
        275                 280                 285
Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser
    290                 295                 300
Thr His Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu
305                 310                 315                 320
Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly
                325                 330                 335
Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser
            340                 345                 350
Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr
        355                 360                 365
Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly
    370                 375                 380
Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu
385                 390                 395                 400
Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala
                405                 410                 415
Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys
            420                 425                 430
Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser
        435                 440                 445
Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val
    450                 455                 460
Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu
465                 470                 475                 480
Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
                485                 490

<210> 1302
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1302
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Glu Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1303
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1303
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Arg Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg
        275                 280                 285
Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser
    290                 295                 300
Thr His Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu
305                 310                 315                 320
Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly
                325                 330                 335
Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser
            340                 345                 350
Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr
        355                 360                 365
Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly
    370                 375                 380
Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu
385                 390                 395                 400
Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala
                405                 410                 415
Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys
            420                 425                 430
Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser
        435                 440                 445
Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val
    450                 455                 460
Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu
465                 470                 475                 480
Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
                485                 490

<210> 1304
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1304
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Glu Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1305
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1305
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Arg Thr Asn Met
    210                 215                 220
Asp Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr
225                 230                 235                 240
Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr
                245                 250                 255
Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu
            260                 265                 270
Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg
        275                 280                 285
Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser
    290                 295                 300
Thr His Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu
305                 310                 315                 320
Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly
                325                 330                 335
Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser
            340                 345                 350
Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr
        355                 360                 365
Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly
    370                 375                 380
Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu
385                 390                 395                 400
Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala
                405                 410                 415
Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys
            420                 425                 430
Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser
        435                 440                 445
Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val
    450                 455                 460
Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu
465                 470                 475                 480
Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
                485                 490

<210> 1306
<211> 700
<212> PRT
<213> Homo sapiens

<400> 1306
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Thr
    210                 215                 220
Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu
225                 230                 235                 240
Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp
                245                 250                 255
Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe
            260                 265                 270
Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His
        275                 280                 285
Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Ala Asp
    290                 295                 300
Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu
305                 310                 315                 320
Ala His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr
                325                 330                 335
Pro His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu
            340                 345                 350
Glu Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu
        355                 360                 365
Gly Tyr Arg Gln Thr Pro Arg Glu Asp Ser His Ser Thr Thr Gly Thr
    370                 375                 380
Ala Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr
385                 390                 395                 400
Pro Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser
                405                 410                 415
His Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp
            420                 425                 430
Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly
        435                 440                 445
Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln
    450                 455                 460
Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu
465                 470                 475                 480
Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn
                485                 490                 495
Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr
            500                 505                 510
Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser
        515                 520                 525
Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val
    530                 535                 540
Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu
545                 550                 555                 560
Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr
                565                 570                 575
His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly
            580                 585                 590
Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp
        595                 600                 605
Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val
    610                 615                 620
Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu
625                 630                 635                 640
Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly
                645                 650                 655
Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn
            660                 665                 670
Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr
        675                 680                 685
Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
    690                 695                 700

<210> 1307
<211> 431
<212> PRT
<213> Homo sapiens

<400> 1307
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg
        275                 280                 285
Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly
    290                 295                 300
Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu
305                 310                 315                 320
Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met
                325                 330                 335
Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu
            340                 345                 350
Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu
        355                 360                 365
Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys
    370                 375                 380
Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys
385                 390                 395                 400
Thr Leu Ala Gly Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser
                405                 410                 415
Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val
            420                 425                 430

<210> 1308
<211> 436
<212> PRT
<213> Homo sapiens

<400> 1308
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Gly Val Lys Arg Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg
    290                 295                 300
Lys Glu Asn Gln Gly Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr
305                 310                 315                 320
Val Ala Ile Asn Leu Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr
                325                 330                 335
Ile Ala Gly Val Met Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys
            340                 345                 350
Asn Gly Val Asn Glu Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val
        355                 360                 365
Gln Asp Thr Ala Glu Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln
    370                 375                 380
Leu His Gly Lys Lys Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys
385                 390                 395                 400
Lys Ala Asn Leu Cys Thr Leu Ala Gly Lys Ile Gln Thr Ile Ile Leu
                405                 410                 415
Lys Asp Ile Thr Ser Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile
            420                 425                 430
Gln Ser Leu Val
        435

<210> 1309
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1309
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1310
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1310
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly
305                 310                 315                 320
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360

<210> 1311
<211> 742
<212> PRT
<213> Homo sapiens

<400> 1311
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu
    210                 215                 220
Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu
225                 230                 235                 240
Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn
                245                 250                 255
His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile
            260                 265                 270
Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg
        275                 280                 285
His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile
    290                 295                 300
Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln
305                 310                 315                 320
Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val
                325                 330                 335
Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr
            340                 345                 350
Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile
        355                 360                 365
His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr
    370                 375                 380
Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys
385                 390                 395                 400
Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro
                405                 410                 415
Arg Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His
            420                 425                 430
Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser
        435                 440                 445
Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly
    450                 455                 460
His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Thr Thr
465                 470                 475                 480
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp
                485                 490                 495
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser
            500                 505                 510
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr
        515                 520                 525
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg
    530                 535                 540
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr
545                 550                 555                 560
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val
                565                 570                 575
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly
            580                 585                 590
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr
        595                 600                 605
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp
    610                 615                 620
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly
625                 630                 635                 640
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser
                645                 650                 655
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser
            660                 665                 670
Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn
        675                 680                 685
Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser
    690                 695                 700
Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr
705                 710                 715                 720
Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val
                725                 730                 735
Asp Met Lys Ile Gly Val
            740

<210> 1312
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1312
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285
Val Asn Ser Arg Arg Ser
    290

<210> 1313
<211> 699
<212> PRT
<213> Homo sapiens

<400> 1313
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr
    210                 215                 220
Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu
225                 230                 235                 240
Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp
                245                 250                 255
Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe
            260                 265                 270
Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His
        275                 280                 285
Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val
    290                 295                 300
Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala
305                 310                 315                 320
His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro
                325                 330                 335
His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu
            340                 345                 350
Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly
        355                 360                 365
Tyr Arg Gln Thr Pro Arg Glu Asp Ser His Ser Thr Thr Gly Thr Ala
    370                 375                 380
Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro
385                 390                 395                 400
Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His
                405                 410                 415
Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser
            420                 425                 430
Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu
        435                 440                 445
Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln
    450                 455                 460
Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp
465                 470                 475                 480
Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp
                485                 490                 495
Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr
            500                 505                 510
Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg
        515                 520                 525
Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr
    530                 535                 540
Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser
545                 550                 555                 560
Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His
                565                 570                 575
Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala
            580                 585                 590
Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu
        595                 600                 605
Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys
    610                 615                 620
Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val
625                 630                 635                 640
Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu
                645                 650                 655
Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys
            660                 665                 670
Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg
        675                 680                 685
Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
    690                 695

<210> 1314
<211> 271
<212> PRT
<213> Homo sapiens

<400> 1314
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Arg Asp Gln Asp Thr Phe His Pro Ser
        195                 200                 205
Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His
    210                 215                 220
Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr
225                 230                 235                 240
Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu
                245                 250                 255
Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Ser
            260                 265                 270

<210> 1315
<211> 338
<212> PRT
<213> Homo sapiens

<400> 1315
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Arg Asp Gln Asp Thr Phe His Pro Ser
        195                 200                 205
Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His
    210                 215                 220
Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr
225                 230                 235                 240
Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu
                245                 250                 255
Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys
            260                 265                 270
Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu
        275                 280                 285
Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu
    290                 295                 300
Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe
305                 310                 315                 320
Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile
                325                 330                 335
Gly Val


<210> 1316
<211> 719
<212> PRT
<213> Homo sapiens

<400> 1316
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Thr Leu Met Ser Thr Ser Ala Thr Ala
        195                 200                 205
Thr Glu Thr Ala Thr Lys Arg Gln Glu Thr Trp Asp Trp Phe Ser Trp
    210                 215                 220
Leu Phe Leu Pro Ser Glu Ser Lys Asn His Leu His Thr Thr Thr Gln
225                 230                 235                 240
Met Ala Gly Thr Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn
                245                 250                 255
Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser
            260                 265                 270
Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr
        275                 280                 285
Pro Arg Ala Phe Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp
    290                 295                 300
Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg
305                 310                 315                 320
Met Thr Asp Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp
                325                 330                 335
Asn Pro Glu Ala His Pro Pro Leu Ile His His Glu His His Glu Glu
            340                 345                 350
Glu Glu Thr Pro His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser
        355                 360                 365
Thr Thr Glu Glu Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg
    370                 375                 380
Trp His Glu Gly Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr
385                 390                 395                 400
Thr Gly Thr Ala Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly
                405                 410                 415
Arg Thr Thr Pro Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn
            420                 425                 430
Pro Ile Ser His Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met
        435                 440                 445
Asp Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro
    450                 455                 460
Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met
465                 470                 475                 480
Thr Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly
                485                 490                 495
Leu Glu Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser
            500                 505                 510
Asn Arg Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu
        515                 520                 525
Gly Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr
    530                 535                 540
Lys Glu Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser
545                 550                 555                 560
Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn
                565                 570                 575
Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser
            580                 585                 590
His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln
        595                 600                 605
Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile
    610                 615                 620
Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile
625                 630                 635                 640
Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys
                645                 650                 655
Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys
            660                 665                 670
Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His
        675                 680                 685
Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala
    690                 695                 700
Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val
705                 710                 715

<210> 1317
<211> 470
<212> PRT
<213> Homo sapiens

<400> 1317
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Asn Met Asp Ser Ser His Ser Ile Thr
        195                 200                 205
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp
    210                 215                 220
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser
225                 230                 235                 240
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr
                245                 250                 255
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg
            260                 265                 270
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr
        275                 280                 285
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val
    290                 295                 300
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly
305                 310                 315                 320
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr
                325                 330                 335
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp
            340                 345                 350
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly
        355                 360                 365
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser
    370                 375                 380
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser
385                 390                 395                 400
Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn
                405                 410                 415
Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser
            420                 425                 430
Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr
        435                 440                 445
Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val
    450                 455                 460
Asp Met Lys Ile Gly Val
465                 470

<210> 1318
<211> 676
<212> PRT
<213> Homo sapiens

<400> 1318
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190
Thr Asp Arg Ile Pro Ala Thr Ser Thr Ser Ser Asn Thr Ile Ser Ala
        195                 200                 205
Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu
    210                 215                 220
Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser
225                 230                 235                 240
Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln Asn Gln
                245                 250                 255
Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu
            260                 265                 270
Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr Thr Ala
        275                 280                 285
Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile His His
    290                 295                 300
Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr Ile Gln
305                 310                 315                 320
Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys Glu Gln
                325                 330                 335
Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro Lys Glu
            340                 345                 350
Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His Thr Ser
        355                 360                 365
His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser Ser Trp
    370                 375                 380
Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly His Gln
385                 390                 395                 400
Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr Leu Gln
                405                 410                 415
Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr
            420                 425                 430
Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser
        435                 440                 445
Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr Thr Ser
    450                 455                 460
Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg Arg Asp
465                 470                 475                 480
Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser
                485                 490                 495
His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val Thr Ser
            500                 505                 510
Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser
        515                 520                 525
Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His
    530                 535                 540
Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His
545                 550                 555                 560
Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile
                565                 570                 575
Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu
            580                 585                 590
Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg
        595                 600                 605
Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala
    610                 615                 620
Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser
625                 630                 635                 640
Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp
                645                 650                 655
Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met
            660                 665                 670
Lys Ile Gly Val
        675

<210> 1319
<211> 742
<212> PRT
<213> Homo sapiens

<400> 1319
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Tyr Asn Thr Ser
            100                 105                 110
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu
    210                 215                 220
Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu
225                 230                 235                 240
Ala Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn
                245                 250                 255
His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile
            260                 265                 270
Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg
        275                 280                 285
His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile
    290                 295                 300
Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln
305                 310                 315                 320
Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val
                325                 330                 335
Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr
            340                 345                 350
Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile
        355                 360                 365
His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr
    370                 375                 380
Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys
385                 390                 395                 400
Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro
                405                 410                 415
Arg Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His
            420                 425                 430
Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser
        435                 440                 445
Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly
    450                 455                 460
His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Thr Thr
465                 470                 475                 480
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asn Leu Asp
                485                 490                 495
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser
            500                 505                 510
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr
        515                 520                 525
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg
    530                 535                 540
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr
545                 550                 555                 560
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val
                565                 570                 575
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly
            580                 585                 590
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr
        595                 600                 605
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp
    610                 615                 620
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly
625                 630                 635                 640
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser
                645                 650                 655
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser
            660                 665                 670
Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn
        675                 680                 685
Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser
    690                 695                 700
Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr
705                 710                 715                 720
Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val
                725                 730                 735
Asp Met Lys Ile Gly Val
            740

<210> 1320
<211> 125
<212> PRT
<213> Homo sapiens

<400> 1320
Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala Thr Pro Ile Ala
 1               5                  10                  15
Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile Gln Ala Ala Phe
            20                  25                  30
Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg Ala Asp His Gln
        35                  40                  45
Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr Ile Ala Leu Cys
    50                  55                  60
Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala Ile Pro Cys Asn
65                  70                  75                  80
Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp Met Leu Ala Arg
                85                  90                  95
Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu His Pro Trp Glu
            100                 105                 110
Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu Glu
        115                 120                 125

<210> 1321
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1321
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1322
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1322
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1323
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1323
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1324
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1324
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Thr Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Ser Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu His Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Thr His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Met Thr Arg
    210                 215                 220
Glu Glu Leu Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Thr Gln Arg Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1325
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1325
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1326
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1326
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1327
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1327
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1328
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1328
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1329
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1329
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Gly Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Leu Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1330
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1330
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1331
<211> 285
<212> PRT
<213> Homo sapiens

<400> 1331
Lys Glu Glu Asp Val Leu Lys Phe Leu Ala Ala Gly Thr His Leu Gly
 1               5                  10                  15
Gly Thr Asn Leu Asp Phe Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys
            20                  25                  30
Ser Asp Gly Ile Tyr Ile Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu
        35                  40                  45
Leu Val Ala Ala Arg Ala Ile Val Ala Ile Glu Asn Pro Ala Asp Val
    50                  55                  60
Ser Val Ile Ser Ser Arg Asn Thr Gly Gln Arg Ala Val Leu Lys Phe
65                  70                  75                  80
Ala Ala Ala Thr Gly Ala Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly
                85                  90                  95
Thr Phe Thr Asn Gln Ile Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu
            100                 105                 110
Val Val Thr Asp Pro Arg Ala Asp His Gln Pro Leu Thr Glu Ala Ser
        115                 120                 125
Tyr Val Asn Leu Pro Thr Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu
    130                 135                 140
Arg Tyr Val Asp Ile Ala Ile Pro Cys Asn Asn Lys Gly Ala His Ser
145                 150                 155                 160
Val Gly Leu Met Trp Trp Met Leu Ala Arg Glu Val Leu Arg Met Arg
                165                 170                 175
Gly Thr Ile Ser Arg Glu His Pro Trp Glu Val Met Pro Asp Leu Tyr
            180                 185                 190
Phe Tyr Arg Asp Pro Glu Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala
        195                 200                 205
Glu Lys Ala Val Thr Lys Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro
    210                 215                 220
Ala Pro Glu Phe Thr Ala Thr Gln Pro Glu Val Ala Asp Trp Ser Glu
225                 230                 235                 240
Gly Val Gln Val Pro Ser Val Pro Ile Gln Gln Phe Pro Thr Glu Asp
                245                 250                 255
Trp Ser Ala Gln Pro Ala Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala
            260                 265                 270
Gln Ala Thr Glu Trp Val Gly Ala Thr Thr Asp Trp Ser
        275                 280                 285

<210> 1332
<211> 300
<212> PRT
<213> Homo sapiens

<400> 1332
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Val Cys Gly Thr Val Arg Ala Val Leu Lys Phe Ala
                85                  90                  95
Ala Ala Thr Gly Ala Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr
            100                 105                 110
Phe Thr Asn Gln Ile Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val
        115                 120                 125
Val Thr Asp Pro Arg Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr
    130                 135                 140
Val Asn Leu Pro Thr Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg
145                 150                 155                 160
Tyr Val Asp Ile Ala Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val
                165                 170                 175
Gly Leu Met Trp Trp Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly
            180                 185                 190
Thr Ile Ser Arg Glu His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe
        195                 200                 205
Tyr Arg Asp Pro Glu Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu
    210                 215                 220
Lys Ala Val Thr Lys Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala
225                 230                 235                 240
Pro Glu Phe Thr Ala Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly
                245                 250                 255
Val Gln Val Pro Ser Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp
            260                 265                 270
Ser Ala Gln Pro Ala Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln
        275                 280                 285
Ala Thr Glu Trp Val Gly Ala Thr Thr Asp Trp Ser
    290                 295                 300

<210> 1333
<211> 169
<212> PRT
<213> Homo sapiens

<400> 1333
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His
                165

<210> 1334
<211> 86
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(86)
<223> Xaa = Any Amino Acid

<400> 1334
Met Arg Ala Val Leu Xaa Phe Ala Ala Ala Thr Gly Ala Thr Pro Ile
 1               5                  10                  15
Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile Gln Ala Ala
            20                  25                  30
Phe Arg Glu Pro Arg Leu Xaa Val Val Thr Asp Pro Arg Ala Asp His
        35                  40                  45
Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr Ile Ala Leu
    50                  55                  60
Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala Ile Pro Cys
65                  70                  75                  80
Asn Asn Lys Gly Ala His
                85

<210> 1335
<211> 86
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(86)
<223> Xaa = Any Amino Acid

<400> 1335
Met Arg Ala Val Leu Xaa Phe Ala Ala Ala Thr Gly Ala Thr Pro Ile
 1               5                  10                  15
Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile Gln Ala Ala
            20                  25                  30
Phe Arg Glu Pro Arg Leu Xaa Val Val Thr Asp Pro Arg Ala Asp His
        35                  40                  45
Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr Ile Ala Leu
    50                  55                  60
Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala Ile Pro Cys
65                  70                  75                  80
Asn Asn Lys Gly Ala His
                85

<210> 1336
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1336
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1337
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1337
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1338
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1338
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1339
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1339
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Thr Ala Arg Ala
    50                  55                  60
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile
            100                 105                 110
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Ser Asp Pro Arg
        115                 120                 125
Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu His Tyr Val Asp Ile Ala
145                 150                 155                 160
Ile Pro Cys Asn Asn Lys Gly Thr His Ser Val Gly Leu Met Trp Trp
                165                 170                 175
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            180                 185                 190
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Met Thr Arg
    210                 215                 220
Glu Glu Leu Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
225                 230                 235                 240
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Thr Gln Arg Ala
            260                 265                 270
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        275                 280                 285
Gly Ala Thr Thr Asp Trp Ser
    290                 295

<210> 1340
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1340
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1341
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1341
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1342
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1342
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1343
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1343
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1344
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1344
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1345
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1345
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1346
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1346
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1347
<211> 277
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(277)
<223> Xaa = Any Amino Acid

<400> 1347
Arg Gln Lys Gly Thr Ala Ala Arg Arg Arg Gln Xaa Gly Leu Leu Ala
 1               5                  10                  15
Ser Ser Arg Pro Glu Pro Ala Asn Glu Arg Lys Met Ala Asp Asn Phe
            20                  25                  30
Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn Pro Asn Pro Gln Gly
        35                  40                  45
Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly Ala Gly Gly Tyr Pro
    50                  55                  60
Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala
65                  70                  75                  80
Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Xaa Gly Ala Pro Gly Ala
                85                  90                  95
Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly Pro Pro Ser Gly
            100                 105                 110
Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser Ala Xaa Gly Ala Tyr
        115                 120                 125
Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro Leu Ile Val Pro
    130                 135                 140
Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met Leu Ile Thr
145                 150                 155                 160
Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe
                165                 170                 175
Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg Phe Asn Glu
            180                 185                 190
Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp Asn Asn Trp
        195                 200                 205
Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser Gly Lys Pro
    210                 215                 220
Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys Val Ala Val
225                 230                 235                 240
Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys Lys Leu Asn
                245                 250                 255
Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala
            260                 265                 270
Ser Tyr Thr Met Ile
        275

<210> 1348
<211> 248
<212> PRT
<213> Homo sapiens

<400> 1348
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Gln Gly Leu Ala Arg Gly Phe Leu Ser Trp Gly Leu Pro Arg Ala Gly
        35                  40                  45
Thr Pro Arg Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly
    50                  55                  60
Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly
65                  70                  75                  80
Pro Pro Ser Gly Pro Gly Tyr Pro Ser Ser Gly Gln Pro Ser Ala Pro
                85                  90                  95
Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro Leu
            100                 105                 110
Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met
        115                 120                 125
Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala
    130                 135                 140
Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg
145                 150                 155                 160
Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp
                165                 170                 175
Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser
            180                 185                 190
Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys
        195                 200                 205
Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys
    210                 215                 220
Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu
225                 230                 235                 240
Thr Ser Ala Ser Tyr Thr Met Ile
                245

<210> 1349
<211> 246
<212> PRT
<213> Homo sapiens

<400> 1349
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Tyr Pro Gly Gln Ala
        35                  40                  45
Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His Gly
    50                  55                  60
Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly
65                  70                  75                  80
Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser Ala
                85                  90                  95
Pro Gly Ala Tyr Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro Leu
            100                 105                 110
Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met
        115                 120                 125
Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala
    130                 135                 140
Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Pro Arg Phe
145                 150                 155                 160
Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp Asn
                165                 170                 175
Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser Gly
            180                 185                 190
Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys Val
        195                 200                 205
Ala Val Asn Asp Ala His Leu Gln Tyr Asn His Arg Val Lys Lys Leu
    210                 215                 220
Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu Thr Ser
225                 230                 235                 240
Ala Ser Tyr Thr Met Ile
                245

<210> 1350
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1350
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile His Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Arg Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1351
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1351
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1352
<211> 249
<212> PRT
<213> Homo sapiens

<400> 1352
Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn Pro
 1               5                  10                  15
Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly Ala
            20                  25                  30
Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln Ala
        35                  40                  45
Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His Gly
    50                  55                  60
Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly
65                  70                  75                  80
Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser Ala
                85                  90                  95
Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro
            100                 105                 110
Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg
        115                 120                 125
Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile
    130                 135                 140
Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro
145                 150                 155                 160
Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu
                165                 170                 175
Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu
            180                 185                 190
Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe
        195                 200                 205
Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val
    210                 215                 220
Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp
225                 230                 235                 240
Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245

<210> 1353
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1353
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly
            20                  25                  30
Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln
        35                  40                  45
Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro
    50                  55                  60
Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro
65                  70                  75                  80
Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser
                85                  90                  95
Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly
            100                 105                 110
Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro
        115                 120                 125
Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg
    130                 135                 140
Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn
145                 150                 155                 160
Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys
                165                 170                 175
Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe
            180                 185                 190
Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His
        195                 200                 205
Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg
    210                 215                 220
Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile
225                 230                 235                 240
Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile
                245                 250

<210> 1354
<211> 798
<212> PRT
<213> Homo sapiens

<400> 1354
Met Ala Glu Asn Ser Val Leu Thr Ser Thr Thr Gly Arg Thr Ser Leu
 1               5                  10                  15
Ala Asp Ser Ser Ile Phe Asp Ser Lys Val Thr Glu Ile Ser Lys Glu
            20                  25                  30
Asn Leu Leu Ile Gly Ser Thr Ser Tyr Val Glu Glu Glu Met Pro Gln
        35                  40                  45
Ile Glu Thr Arg Val Ile Leu Val Gln Glu Ala Gly Lys Gln Glu Glu
    50                  55                  60
Leu Thr Lys Ala Leu Lys Asp Ile Lys Val Gly Phe Val Lys Met Glu
65                  70                  75                  80
Ser Val Glu Glu Phe Glu Gly Leu Asp Ser Pro Glu Phe Glu Asn Val
                85                  90                  95
Phe Val Val Thr Asp Phe Gln Asp Ser Val Phe Asn Asp Leu Tyr Lys
            100                 105                 110
Ala Asp Cys Arg Val Ile Gly Pro Pro Val Val Leu Asn Cys Ser Gln
        115                 120                 125
Lys Gly Glu Pro Leu Pro Phe Ser Cys Arg Pro Leu Tyr Cys Thr Ser
    130                 135                 140
Met Met Asn Leu Val Leu Cys Phe Thr Gly Phe Arg Lys Lys Glu Glu
145                 150                 155                 160
Leu Val Arg Leu Val Thr Leu Val His His Met Gly Gly Val Ile Arg
                165                 170                 175
Lys Asp Phe Asn Ser Lys Val Thr His Leu Val Ala Asn Cys Thr Gln
            180                 185                 190
Gly Glu Lys Phe Arg Val Ala Val Ser Leu Gly Thr Pro Ile Met Lys
        195                 200                 205
Pro Glu Trp Ile Tyr Lys Ala Trp Glu Arg Arg Asn Glu Gln Asp Phe
    210                 215                 220
Tyr Ala Ala Val Asp Asp Phe Arg Asn Glu Phe Lys Val Pro Pro Phe
225                 230                 235                 240
Gln Asp Cys Ile Phe Ser Phe Leu Gly Phe Ser Asp Glu Glu Lys Thr
                245                 250                 255
Asn Met Glu Glu Met Thr Glu Met Gln Gly Gly Lys Tyr Leu Pro Leu
            260                 265                 270
Gly Asp Glu Arg Cys Thr His Leu Val Val Glu Glu Asn Ile Val Lys
        275                 280                 285
Asp Leu Pro Phe Glu Pro Ser Lys Lys Leu Tyr Val Val Lys Gln Glu
    290                 295                 300
Trp Phe Trp Gly Ser Ile Gln Met Asp Ala Arg Ala Gly Glu Thr Met
305                 310                 315                 320
Tyr Leu Tyr Glu Lys Ala Asn Thr Pro Glu Leu Lys Lys Ser Val Ser
                325                 330                 335
Met Leu Ser Leu Asn Thr Pro Asn Ser Asn Arg Lys Arg Arg Arg Leu
            340                 345                 350
Lys Glu Thr Leu Ala Gln Leu Ser Arg Asp Thr Asp Val Ser Pro Phe
        355                 360                 365
Pro Pro Arg Lys Arg Pro Ser Ala Glu His Ser Leu Ser Ile Gly Ser
    370                 375                 380
Leu Leu Asp Ile Ser Asn Thr Pro Glu Ser Ser Ile Asn Tyr Gly Asp
385                 390                 395                 400
Thr Pro Lys Ser Cys Thr Lys Ser Ser Lys Ser Ser Thr Pro Val Pro
                405                 410                 415
Ser Lys Gln Ser Ala Arg Trp Gln Val Ala Lys Glu Leu Tyr Gln Thr
            420                 425                 430
Glu Ser Asn Tyr Val Asn Ile Leu Ala Thr Ile Ile Gln Leu Phe Gln
        435                 440                 445
Val Pro Leu Glu Glu Glu Gly Gln Arg Gly Gly Pro Ile Leu Ala Pro
    450                 455                 460
Glu Glu Ile Lys Thr Ile Phe Gly Ser Ile Pro Asp Ile Phe Asp Val
465                 470                 475                 480
His Thr Lys Ile Lys Asp Asp Leu Glu Asp Leu Ile Val Asn Trp Asp
                485                 490                 495
Glu Ser Lys Ser Ile Gly Asp Ile Phe Leu Lys Tyr Ser Lys Asp Leu
            500                 505                 510
Val Lys Thr Tyr Pro Pro Phe Val Asn Phe Phe Glu Met Ser Lys Glu
        515                 520                 525
Thr Ile Ile Lys Cys Glu Lys Gln Lys Pro Arg Phe His Ala Phe Leu
    530                 535                 540
Lys Ile Asn Gln Ala Lys Pro Glu Cys Gly Arg Gln Ser Leu Val Glu
545                 550                 555                 560
Leu Leu Ile Arg Pro Val Gln Arg Leu Pro Ser Val Ala Leu Leu Leu
                565                 570                 575
Asn Asp Leu Lys Lys His Thr Ala Asp Glu Asn Pro Asp Lys Ser Thr
            580                 585                 590
Leu Glu Lys Ala Ile Gly Ser Leu Lys Glu Val Met Thr His Ile Asn
        595                 600                 605
Glu Asp Lys Arg Lys Thr Glu Ala Gln Lys Gln Ile Phe Asp Val Val
    610                 615                 620
Tyr Glu Val Asp Gly Cys Pro Ala Asn Leu Leu Ser Ser His Arg Ser
625                 630                 635                 640
Leu Val Gln Arg Val Glu Thr Ile Ser Leu Gly Glu His Pro Cys Asp
                645                 650                 655
Arg Gly Glu Gln Val Thr Leu Phe Leu Phe Asn Asp Cys Leu Glu Ile
            660                 665                 670
Ala Arg Lys Arg His Lys Val Ile Gly Thr Phe Arg Ser Pro His Gly
        675                 680                 685
Gln Thr Arg Pro Pro Ala Ser Leu Lys His Ile His Leu Met Pro Leu
    690                 695                 700
Ser Gln Ile Lys Lys Val Leu Asp Ile Arg Glu Thr Glu Asp Cys His
705                 710                 715                 720
Asn Ala Phe Ala Leu Leu Val Arg Pro Pro Thr Glu Gln Ala Asn Val
                725                 730                 735
Leu Leu Ser Phe Gln Met Thr Ser Asp Glu Leu Pro Lys Glu Asn Trp
            740                 745                 750
Leu Lys Met Leu Cys Arg His Val Ala Asn Thr Ile Cys Lys Ala Asp
        755                 760                 765
Ala Glu Asn Leu Ile Tyr Thr Ala Asp Pro Glu Ser Phe Glu Val Asn
    770                 775                 780
Thr Lys Asp Met Asp Ser Thr Leu Ser Arg Ala Ser Arg Ala
785                 790                 795

<210> 1355
<211> 914
<212> PRT
<213> Homo sapiens

<400> 1355
Met Ala Glu Asn Ser Val Leu Thr Ser Thr Thr Gly Arg Thr Ser Leu
 1               5                  10                  15
Ala Asp Ser Ser Ile Phe Asp Ser Lys Val Thr Glu Ile Ser Lys Glu
            20                  25                  30
Asn Leu Leu Ile Gly Ser Thr Ser Tyr Val Glu Glu Glu Met Pro Gln
        35                  40                  45
Ile Glu Thr Arg Val Ile Leu Val Gln Glu Ala Gly Lys Gln Glu Glu
    50                  55                  60
Leu Ile Lys Ala Leu Lys Thr Ile Lys Ile Met Glu Val Pro Val Ile
65                  70                  75                  80
Lys Ile Lys Glu Ser Cys Pro Gly Lys Ser Asp Glu Lys Leu Ile Lys
                85                  90                  95
Ser Val Ile Asn Met Asp Ile Lys Val Gly Phe Val Lys Met Glu Ser
            100                 105                 110
Val Glu Glu Phe Glu Gly Leu Asp Ser Pro Glu Phe Glu Asn Val Phe
        115                 120                 125
Val Val Thr Asp Phe Gln Asp Ser Val Phe Asn Asp Leu Tyr Lys Ala
    130                 135                 140
Asp Cys Arg Val Ile Gly Pro Pro Val Val Leu Asn Cys Ser Gln Lys
145                 150                 155                 160
Gly Glu Pro Leu Pro Phe Ser Cys Arg Pro Leu Tyr Arg Thr Ser Met
                165                 170                 175
Met Asn Leu Val Leu Cys Phe Thr Gly Phe Arg Lys Lys Glu Glu Leu
            180                 185                 190
Val Arg Leu Val Thr Leu Val His His Met Gly Gly Val Ile Arg Lys
        195                 200                 205
Asp Phe Ser Ser Lys Val Thr His Leu Val Ala Asn Cys Thr Gln Gly
    210                 215                 220
Glu Lys Phe Arg Val Ala Val Ser Leu Gly Thr Pro Ile Met Lys Pro
225                 230                 235                 240
Glu Trp Ile Tyr Lys Ala Trp Glu Arg Arg Asn Glu Gln Asp Phe Tyr
                245                 250                 255
Ala Ala Val Asp Asp Phe Arg Asn Glu Phe Lys Val Pro Pro Phe Gln
            260                 265                 270
Asp Cys Ile Leu Ser Phe Leu Gly Phe Ser Asp Glu Glu Lys Thr Asn
        275                 280                 285
Met Glu Glu Met Thr Glu Met Gln Gly Gly Lys Tyr Leu Pro Leu Gly
    290                 295                 300
Asp Glu Arg Cys Thr His Leu Val Val Glu Glu Asn Ile Val Lys Asp
305                 310                 315                 320
Leu Pro Phe Glu Pro Ser Lys Lys Leu Tyr Val Val Lys Gln Glu Trp
                325                 330                 335
Phe Trp Gly Ser Ile Gln Met Asp Ala Arg Ala Gly Glu Thr Met Tyr
            340                 345                 350
Leu Tyr Glu Lys Ala Asn Thr Pro Glu Leu Lys Lys Ser Val Ser Met
        355                 360                 365
Leu Ser Leu Asn Thr Pro Asn Ser Asn Arg Lys Arg Arg Arg Leu Lys
    370                 375                 380
Glu Thr Leu Ala Gln Leu Ser Arg Glu Thr Asp Val Ser Pro Phe Pro
385                 390                 395                 400
Pro Arg Lys Arg Pro Ser Ala Glu His Ser Leu Ser Ile Gly Ser Leu
                405                 410                 415
Leu Asp Ile Ser Asn Thr Pro Glu Ser Ser Ile Asn Tyr Gly Asp Thr
            420                 425                 430
Pro Lys Ser Cys Thr Lys Ser Ser Lys Ser Ser Thr Pro Val Pro Ser
        435                 440                 445
Lys Gln Ser Ala Arg Trp Gln Val Ala Lys Glu Leu Tyr Gln Thr Glu
    450                 455                 460
Ser Asn Tyr Val Asn Ile Leu Ala Thr Ile Ile Gln Leu Phe Gln Val
465                 470                 475                 480
Pro Leu Glu Glu Glu Gly Gln Arg Gly Gly Pro Ile Leu Ala Pro Glu
                485                 490                 495
Glu Ile Lys Thr Ile Phe Gly Ser Ile Pro Asp Ile Phe Asp Val His
            500                 505                 510
Thr Lys Ile Lys Asp Asp Leu Glu Asp Leu Ile Val Asn Trp Asp Glu
        515                 520                 525
Ser Lys Ser Ile Gly Asp Ile Phe Leu Lys Tyr Ser Lys Asp Leu Val
    530                 535                 540
Lys Thr Tyr Pro Pro Phe Val Asn Phe Phe Glu Met Ser Lys Glu Thr
545                 550                 555                 560
Ile Ile Lys Cys Glu Lys Gln Lys Pro Arg Phe His Ala Phe Leu Lys
                565                 570                 575
Ile Asn Gln Ala Lys Pro Glu Cys Gly Arg Gln Ser Leu Val Glu Leu
            580                 585                 590
Leu Ile Arg Pro Val Gln Arg Leu Pro Ser Val Ala Leu Leu Leu Asn
        595                 600                 605
Asp Leu Lys Lys His Thr Ala Asp Glu Asn Pro Asp Lys Ser Thr Leu
    610                 615                 620
Glu Lys Ala Ile Gly Ser Leu Lys Glu Val Met Thr His Ile Asn Glu
625                 630                 635                 640
Asp Lys Arg Lys Thr Glu Ala Gln Lys Gln Ile Phe Asp Val Val Tyr
                645                 650                 655
Glu Val Asp Gly Cys Pro Ala Asn Leu Leu Ser Ser His Arg Ser Leu
            660                 665                 670
Val Gln Arg Val Glu Thr Ile Ser Leu Gly Glu His Pro Cys Asp Arg
        675                 680                 685
Gly Glu Gln Val Thr Leu Phe Leu Phe Asn Asp Cys Leu Glu Ile Ala
    690                 695                 700
Arg Lys Arg His Lys Val Ile Gly Thr Phe Arg Ser Pro His Gly Gln
705                 710                 715                 720
Thr Arg Pro Pro Ala Ser Leu Lys His Ile His Leu Met Pro Leu Ser
                725                 730                 735
Gln Ile Lys Lys Val Leu Asp Ile Arg Glu Thr Glu Asp Cys His Asn
            740                 745                 750
Ala Phe Ala Leu Leu Val Arg Pro Pro Thr Glu Gln Ala Asn Val Leu
        755                 760                 765
Leu Ser Phe Gln Met Thr Ser Asp Glu Leu Pro Lys Glu Asn Trp Leu
    770                 775                 780
Lys Met Leu Cys Arg His Val Ala Asn Thr Ile Cys Lys Ala Asp Ala
785                 790                 795                 800
Glu Asn Leu Ile Tyr Thr Ala Asp Pro Glu Ser Phe Glu Val Asn Thr
                805                 810                 815
Lys Asp Met Asp Ser Thr Leu Ser Arg Ala Ser Arg Ala Ile Lys Lys
            820                 825                 830
Thr Ser Lys Lys Val Thr Arg Ala Phe Ser Phe Ser Lys Thr Pro Lys
        835                 840                 845
Arg Ala Leu Arg Arg Ala Leu Met Thr Ser His Gly Ser Val Glu Gly
    850                 855                 860
Arg Ser Pro Ser Ser Asn Asp Lys His Val Met Ser Arg Leu Ser Ser
865                 870                 875                 880
Thr Ser Ser Leu Ala Gly Ile Pro Ser Pro Ser Leu Val Ser Leu Pro
                885                 890                 895
Ser Phe Phe Glu Arg Arg Ser His Thr Leu Ser Arg Ser Thr Thr His
            900                 905                 910
Leu Ile


<210> 1356
<211> 798
<212> PRT
<213> Homo sapiens

<400> 1356
Met Ala Glu Asn Ser Val Leu Thr Ser Thr Thr Gly Arg Thr Ser Leu
 1               5                  10                  15
Ala Asp Ser Ser Ile Phe Asp Ser Lys Val Thr Glu Ile Ser Lys Glu
            20                  25                  30
Asn Leu Leu Ile Gly Ser Thr Ser Tyr Val Glu Glu Glu Met Pro Gln
        35                  40                  45
Ile Glu Thr Arg Val Ile Leu Val Gln Glu Ala Gly Lys Gln Glu Glu
    50                  55                  60
Leu Thr Lys Ala Leu Lys Asp Ile Lys Val Gly Phe Val Lys Met Glu
65                  70                  75                  80
Ser Val Glu Glu Phe Glu Gly Leu Asp Ser Pro Glu Phe Glu Asn Val
                85                  90                  95
Phe Val Val Thr Asp Phe Gln Asp Ser Val Phe Asn Asp Leu Tyr Lys
            100                 105                 110
Ala Asp Cys Arg Val Ile Gly Pro Pro Val Val Leu Asn Cys Ser Gln
        115                 120                 125
Lys Gly Glu Pro Leu Pro Phe Ser Cys Arg Pro Leu Tyr Cys Thr Ser
    130                 135                 140
Met Met Asn Leu Val Leu Cys Phe Thr Gly Phe Arg Lys Lys Glu Glu
145                 150                 155                 160
Leu Val Arg Leu Val Thr Leu Val His His Met Gly Gly Val Ile Arg
                165                 170                 175
Lys Asp Phe Asn Ser Lys Val Thr His Leu Val Ala Asn Cys Thr Gln
            180                 185                 190
Gly Glu Lys Phe Arg Val Ala Val Ser Leu Gly Thr Pro Ile Met Lys
        195                 200                 205
Pro Glu Trp Ile Tyr Lys Ala Trp Glu Arg Arg Asn Glu Gln Asp Phe
    210                 215                 220
Tyr Ala Ala Val Asp Asp Phe Arg Asn Glu Phe Lys Val Pro Pro Phe
225                 230                 235                 240
Gln Asp Cys Ile Phe Ser Phe Leu Gly Phe Ser Asp Glu Glu Lys Thr
                245                 250                 255
Asn Met Glu Glu Met Thr Glu Met Gln Gly Gly Lys Tyr Leu Pro Leu
            260                 265                 270
Gly Asp Glu Arg Cys Thr His Leu Val Val Glu Glu Asn Ile Val Lys
        275                 280                 285
Asp Leu Pro Phe Glu Pro Ser Lys Lys Leu Tyr Val Val Lys Gln Glu
    290                 295                 300
Trp Phe Trp Gly Ser Ile Gln Met Asp Ala Arg Ala Gly Glu Thr Met
305                 310                 315                 320
Tyr Leu Tyr Glu Lys Ala Asn Thr Pro Glu Leu Lys Lys Ser Val Ser
                325                 330                 335
Met Leu Ser Leu Asn Thr Pro Asn Ser Asn Arg Lys Arg Arg Arg Leu
            340                 345                 350
Lys Glu Thr Leu Ala Gln Leu Ser Arg Asp Thr Asp Val Ser Pro Phe
        355                 360                 365
Pro Pro Arg Lys Arg Pro Ser Ala Glu His Ser Leu Ser Ile Gly Ser
    370                 375                 380
Leu Leu Asp Ile Ser Asn Thr Pro Glu Ser Ser Ile Asn Tyr Gly Asp
385                 390                 395                 400
Thr Pro Lys Ser Cys Thr Lys Ser Ser Lys Ser Ser Thr Pro Val Pro
                405                 410                 415
Ser Lys Gln Ser Ala Arg Trp Gln Val Ala Lys Glu Leu Tyr Gln Thr
            420                 425                 430
Glu Ser Asn Tyr Val Asn Ile Leu Ala Thr Ile Ile Gln Leu Phe Gln
        435                 440                 445
Val Pro Leu Glu Glu Glu Gly Gln Arg Gly Gly Pro Ile Leu Ala Pro
    450                 455                 460
Glu Glu Ile Lys Thr Ile Phe Gly Ser Ile Pro Asp Ile Phe Asp Val
465                 470                 475                 480
His Thr Lys Ile Lys Asp Asp Leu Glu Asp Leu Ile Val Asn Trp Asp
                485                 490                 495
Glu Ser Lys Ser Ile Gly Asp Ile Phe Leu Lys Tyr Ser Lys Asp Leu
            500                 505                 510
Val Lys Thr Tyr Pro Pro Phe Val Asn Phe Phe Glu Met Ser Lys Glu
        515                 520                 525
Thr Ile Ile Lys Cys Glu Lys Gln Lys Pro Arg Phe His Ala Phe Leu
    530                 535                 540
Lys Ile Asn Gln Ala Lys Pro Glu Cys Gly Arg Gln Ser Leu Val Glu
545                 550                 555                 560
Leu Leu Ile Arg Pro Val Gln Arg Leu Pro Ser Val Ala Leu Leu Leu
                565                 570                 575
Asn Asp Leu Lys Lys His Thr Ala Asp Glu Asn Pro Asp Lys Ser Thr
            580                 585                 590
Leu Glu Lys Ala Ile Gly Ser Leu Lys Glu Val Met Thr His Ile Asn
        595                 600                 605
Glu Asp Lys Arg Lys Thr Glu Ala Gln Lys Gln Ile Phe Asp Val Val
    610                 615                 620
Tyr Glu Val Asp Gly Cys Pro Ala Asn Leu Leu Ser Ser His Arg Ser
625                 630                 635                 640
Leu Val Gln Arg Val Glu Thr Ile Ser Leu Gly Glu His Pro Cys Asp
                645                 650                 655
Arg Gly Glu Gln Val Thr Leu Phe Leu Phe Asn Asp Cys Leu Glu Ile
            660                 665                 670
Ala Arg Lys Arg His Lys Val Ile Gly Thr Phe Arg Ser Pro His Gly
        675                 680                 685
Gln Thr Arg Pro Pro Ala Ser Leu Lys His Ile His Leu Met Pro Leu
    690                 695                 700
Ser Gln Ile Lys Lys Val Leu Asp Ile Arg Glu Thr Glu Asp Cys His
705                 710                 715                 720
Asn Ala Phe Ala Leu Leu Val Arg Pro Pro Thr Glu Gln Ala Asn Val
                725                 730                 735
Leu Leu Ser Phe Gln Met Thr Ser Asp Glu Leu Pro Lys Glu Asn Trp
            740                 745                 750
Leu Lys Met Leu Cys Arg His Val Ala Asn Thr Ile Cys Lys Ala Asp
        755                 760                 765
Ala Glu Asn Leu Ile Tyr Thr Ala Asp Pro Glu Ser Phe Glu Val Asn
    770                 775                 780
Thr Lys Asp Met Asp Ser Thr Leu Ser Arg Ala Ser Arg Ala
785                 790                 795

<210> 1357
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(112)
<223> Xaa = Any Amino Acid

<400> 1357
Asn Val Phe Val Val Thr Asp Phe Gln Asp Ser Val Phe Asn Asp Leu
 1               5                  10                  15
Tyr Lys Ala Asp Cys Arg Val Ile Gly Pro Pro Val Val Leu Asn Cys
            20                  25                  30
Ser Gln Lys Gly Glu Pro Leu Pro Phe Ser Cys Arg Pro Leu Tyr Cys
        35                  40                  45
Thr Ser Met Met Asn Leu Val Leu Cys Phe Thr Gly Phe Arg Lys Lys
    50                  55                  60
Glu Glu Leu Val Arg Leu Val Thr Leu Val His His Xaa Gly Gly Val
65                  70                  75                  80
Ile Arg Lys Asp Phe Asn Ser Lys Xaa Thr His Leu Val Ala Ile Val
                85                  90                  95
His Lys Glu Lys Ile Gln Gly Cys Cys Glu Ser Arg Tyr Ser Ile Met
            100                 105                 110

<210> 1358
<211> 883
<212> PRT
<213> Homo sapiens

<400> 1358
Met Ala Glu Asn Ser Val Leu Thr Ser Thr Thr Gly Arg Thr Ser Leu
 1               5                  10                  15
Ala Asp Ser Ser Ile Phe Asp Ser Lys Val Thr Glu Ile Ser Lys Glu
            20                  25                  30
Asn Leu Leu Ile Gly Ser Thr Ser Tyr Val Glu Glu Glu Met Pro Gln
        35                  40                  45
Ile Glu Thr Arg Val Ile Leu Val Gln Glu Ala Gly Lys Gln Glu Glu
    50                  55                  60
Leu Thr Lys Ala Leu Lys Asp Ile Lys Val Gly Phe Val Lys Met Glu
65                  70                  75                  80
Ser Val Glu Glu Phe Glu Gly Leu Asp Ser Pro Glu Phe Glu Asn Val
                85                  90                  95
Phe Val Val Thr Asp Phe Gln Asp Ser Val Phe Asn Asp Leu Tyr Lys
            100                 105                 110
Ala Asp Cys Arg Val Ile Gly Pro Pro Val Val Leu Asn Cys Ser Gln
        115                 120                 125
Lys Gly Glu Pro Leu Pro Phe Ser Cys Arg Pro Leu Tyr Cys Thr Ser
    130                 135                 140
Met Met Asn Leu Val Leu Cys Phe Thr Gly Phe Arg Lys Lys Glu Glu
145                 150                 155                 160
Leu Val Arg Leu Val Thr Leu Val His His Met Gly Gly Val Ile Arg
                165                 170                 175
Lys Asp Phe Asn Ser Lys Val Thr His Leu Val Ala Asn Cys Thr Gln
            180                 185                 190
Gly Glu Lys Phe Arg Val Ala Val Ser Leu Gly Thr Pro Ile Met Lys
        195                 200                 205
Pro Glu Trp Ile Tyr Lys Ala Trp Glu Arg Arg Asn Glu Gln Asp Phe
    210                 215                 220
Tyr Ala Ala Val Asp Asp Phe Arg Asn Glu Phe Lys Val Pro Pro Phe
225                 230                 235                 240
Gln Asp Cys Ile Phe Ser Phe Leu Gly Phe Ser Asp Glu Glu Lys Thr
                245                 250                 255
Asn Met Glu Glu Met Thr Glu Met Gln Gly Gly Lys Tyr Leu Pro Leu
            260                 265                 270
Gly Asp Glu Arg Cys Thr His Leu Val Val Glu Glu Asn Ile Val Lys
        275                 280                 285
Asp Leu Pro Phe Glu Pro Ser Lys Lys Leu Tyr Val Val Lys Gln Glu
    290                 295                 300
Trp Phe Trp Gly Ser Ile Gln Met Asp Ala Arg Ala Gly Glu Thr Met
305                 310                 315                 320
Tyr Leu Tyr Glu Lys Ala Asn Thr Pro Glu Leu Lys Lys Ser Val Ser
                325                 330                 335
Met Leu Ser Leu Asn Thr Pro Asn Ser Asn Arg Lys Arg Arg Arg Leu
            340                 345                 350
Lys Glu Thr Leu Ala Gln Leu Ser Arg Asp Thr Asp Val Ser Pro Phe
        355                 360                 365
Pro Pro Arg Lys Arg Pro Ser Ala Glu His Ser Leu Ser Ile Gly Ser
    370                 375                 380
Leu Leu Asp Ile Ser Asn Thr Pro Glu Ser Ser Ile Asn Tyr Gly Asp
385                 390                 395                 400
Thr Pro Lys Ser Cys Thr Lys Ser Ser Lys Ser Ser Thr Pro Val Pro
                405                 410                 415
Ser Lys Gln Ser Ala Arg Trp Gln Val Ala Lys Glu Leu Tyr Gln Thr
            420                 425                 430
Glu Ser Asn Tyr Val Asn Ile Leu Ala Thr Ile Ile Gln Leu Phe Gln
        435                 440                 445
Val Pro Leu Glu Glu Glu Gly Gln Arg Gly Gly Pro Ile Leu Ala Pro
    450                 455                 460
Glu Glu Ile Lys Thr Ile Phe Gly Ser Ile Pro Asp Ile Phe Asp Val
465                 470                 475                 480
His Thr Lys Ile Lys Asp Asp Leu Glu Asp Leu Ile Val Asn Trp Asp
                485                 490                 495
Glu Ser Lys Ser Ile Gly Asp Ile Phe Leu Lys Tyr Ser Lys Asp Leu
            500                 505                 510
Val Lys Thr Tyr Pro Pro Phe Val Asn Phe Phe Glu Met Ser Lys Glu
        515                 520                 525
Thr Ile Ile Lys Cys Glu Lys Gln Lys Pro Arg Phe His Ala Phe Leu
    530                 535                 540
Lys Ile Asn Gln Ala Lys Pro Glu Cys Gly Arg Gln Ser Leu Val Glu
545                 550                 555                 560
Leu Leu Ile Arg Pro Val Gln Arg Leu Pro Ser Val Ala Leu Leu Leu
                565                 570                 575
Asn Asp Leu Lys Lys His Thr Ala Asp Glu Asn Pro Asp Lys Ser Thr
            580                 585                 590
Leu Glu Lys Ala Ile Gly Ser Leu Lys Glu Val Met Thr His Ile Asn
        595                 600                 605
Glu Asp Lys Arg Lys Thr Glu Ala Gln Lys Gln Ile Phe Asp Val Val
    610                 615                 620
Tyr Glu Val Asp Gly Cys Pro Ala Asn Leu Leu Ser Ser His Arg Ser
625                 630                 635                 640
Leu Val Gln Arg Val Glu Thr Ile Ser Leu Gly Glu His Pro Cys Asp
                645                 650                 655
Arg Gly Glu Gln Val Thr Leu Phe Leu Phe Asn Asp Cys Leu Glu Ile
            660                 665                 670
Ala Arg Lys Arg His Lys Val Ile Gly Thr Phe Arg Ser Pro His Gly
        675                 680                 685
Gln Thr Arg Pro Pro Ala Ser Leu Lys His Ile His Leu Met Pro Leu
    690                 695                 700
Ser Gln Ile Lys Lys Val Leu Asp Ile Arg Glu Thr Glu Asp Cys His
705                 710                 715                 720
Asn Ala Phe Ala Leu Leu Val Arg Pro Pro Thr Glu Gln Ala Asn Val
                725                 730                 735
Leu Leu Ser Phe Gln Met Thr Ser Asp Glu Leu Pro Lys Glu Asn Trp
            740                 745                 750
Leu Lys Met Leu Cys Arg His Val Ala Asn Thr Ile Cys Lys Ala Asp
        755                 760                 765
Ala Glu Asn Leu Ile Tyr Thr Ala Asp Pro Glu Ser Phe Glu Val Asn
    770                 775                 780
Thr Lys Asp Met Asp Ser Thr Leu Ser Arg Ala Ser Arg Ala Ile Lys
785                 790                 795                 800
Lys Thr Ser Lys Lys Val Thr Arg Ala Phe Ser Phe Ser Lys Thr Pro
                805                 810                 815
Lys Arg Ala Leu Arg Arg Ala Leu Met Thr Ser His Gly Ser Val Glu
            820                 825                 830
Gly Arg Ser Pro Ser Ser Asn Asp Lys His Val Met Ser Arg Leu Ser
        835                 840                 845
Ser Thr Ser Ser Leu Ala Gly Ile Pro Ser Pro Ser Leu Val Ser Leu
    850                 855                 860
Pro Ser Phe Phe Glu Arg Arg Ser His Thr Leu Ser Arg Ser Thr Thr
865                 870                 875                 880
His Leu Ile


<210> 1359
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1359
Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile
 1               5                  10                  15
Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu
            20                  25                  30
Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile
        35                  40                  45
Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro
    50                  55                  60
Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala
65                  70                  75                  80
Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu
                85                  90                  95
Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe
            100                 105                 110
Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile
        115                 120                 125
Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys
    130                 135                 140
Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu
145                 150                 155                 160
Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val
                165                 170                 175
Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile
            180                 185                 190
Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp
        195                 200                 205
Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala
    210                 215                 220
Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr
225                 230                 235                 240
Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile
                245                 250                 255
Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val
            260                 265                 270
Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala
        275                 280                 285
Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile
    290                 295                 300
Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr
305                 310                 315                 320
Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His
                325                 330                 335
Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala
            340                 345                 350
Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro
        355                 360                 365
Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu
    370                 375                 380
Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg
385                 390                 395                 400
Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu
                405                 410                 415
Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys
            420                 425                 430
Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu
        435                 440                 445
Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys
    450                 455                 460
Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val
465                 470                 475                 480
Pro Pro Glu Glu Asp Pro Glu
                485

<210> 1360
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1360
Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile
 1               5                  10                  15
Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu
            20                  25                  30
Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile
        35                  40                  45
Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro
    50                  55                  60
Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala
65                  70                  75                  80
Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu
                85                  90                  95
Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe
            100                 105                 110
Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile
        115                 120                 125
Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys
    130                 135                 140
Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu
145                 150                 155                 160
Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val
                165                 170                 175
Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile
            180                 185                 190
Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp
        195                 200                 205
Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala
    210                 215                 220
Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr
225                 230                 235                 240
Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile
                245                 250                 255
Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val
            260                 265                 270
Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala
        275                 280                 285
Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile
    290                 295                 300
Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr
305                 310                 315                 320
Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His
                325                 330                 335
Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala
            340                 345                 350
Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro
        355                 360                 365
Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu
    370                 375                 380
Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg
385                 390                 395                 400
Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu
                405                 410                 415
Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys
            420                 425                 430
Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu
        435                 440                 445
Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys
    450                 455                 460
Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val
465                 470                 475                 480
Pro Pro Glu Glu Asp Pro Glu
                485

<210> 1361
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1361
Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile
 1               5                  10                  15
Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu
            20                  25                  30
Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile
        35                  40                  45
Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro
    50                  55                  60
Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala
65                  70                  75                  80
Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu
                85                  90                  95
Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe
            100                 105                 110
Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile
        115                 120                 125
Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys
    130                 135                 140
Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu
145                 150                 155                 160
Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val
                165                 170                 175
Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile
            180                 185                 190
Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp
        195                 200                 205
Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala
    210                 215                 220
Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr
225                 230                 235                 240
Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile
                245                 250                 255
Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val
            260                 265                 270
Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala
        275                 280                 285
Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile
    290                 295                 300
Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr
305                 310                 315                 320
Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His
                325                 330                 335
Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala
            340                 345                 350
Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro
        355                 360                 365
Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu
    370                 375                 380
Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg
385                 390                 395                 400
Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu
                405                 410                 415
Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys
            420                 425                 430
Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu
        435                 440                 445
Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys
    450                 455                 460
Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val
465                 470                 475                 480
Pro Pro Glu Glu Asp Pro Glu
                485

<210> 1362
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1362
Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile
 1               5                  10                  15
Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu
            20                  25                  30
Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile
        35                  40                  45
Phe Val Ser Ser Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro
    50                  55                  60
Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala
65                  70                  75                  80
Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu
                85                  90                  95
Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe
            100                 105                 110
Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile
        115                 120                 125
Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys
    130                 135                 140
Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu
145                 150                 155                 160
Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val
                165                 170                 175
Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile
            180                 185                 190
Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp
        195                 200                 205
Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala
    210                 215                 220
Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr
225                 230                 235                 240
Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile
                245                 250                 255
Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val
            260                 265                 270
Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala
        275                 280                 285
Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile
    290                 295                 300
Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr
305                 310                 315                 320
Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His
                325                 330                 335
Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala
            340                 345                 350
Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro
        355                 360                 365
Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu
    370                 375                 380
Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg
385                 390                 395                 400
Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu
                405                 410                 415
Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys
            420                 425                 430
Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu
        435                 440                 445
Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys
    450                 455                 460
Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val
465                 470                 475                 480
Pro Pro Glu Glu Asp Pro Glu
                485

<210> 1363
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1363
Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile
 1               5                  10                  15
Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu
            20                  25                  30
Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile
        35                  40                  45
Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro
    50                  55                  60
Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala
65                  70                  75                  80
Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu
                85                  90                  95
Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe
            100                 105                 110
Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile
        115                 120                 125
Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys
    130                 135                 140
Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu
145                 150                 155                 160
Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val
                165                 170                 175
Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile
            180                 185                 190
Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp
        195                 200                 205
Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala
    210                 215                 220
Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr
225                 230                 235                 240
Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile
                245                 250                 255
Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val
            260                 265                 270
Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala
        275                 280                 285
Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile
    290                 295                 300
Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr
305                 310                 315                 320
Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His
                325                 330                 335
Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala
            340                 345                 350
Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro
        355                 360                 365
Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu
    370                 375                 380
Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg
385                 390                 395                 400
Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu
                405                 410                 415
Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys
            420                 425                 430
Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu
        435                 440                 445
Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys
    450                 455                 460
Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val
465                 470                 475                 480
Pro Pro Glu Glu Asp Pro Glu
                485

<210> 1364
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1364
Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile
 1               5                  10                  15
Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu
            20                  25                  30
Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile
        35                  40                  45
Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro
    50                  55                  60
Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala
65                  70                  75                  80
Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu
                85                  90                  95
Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe
            100                 105                 110
Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile
        115                 120                 125
Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys
    130                 135                 140
Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu
145                 150                 155                 160
Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val
                165                 170                 175
Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile
            180                 185                 190
Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp
        195                 200                 205
Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala
    210                 215                 220
Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr
225                 230                 235                 240
Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile
                245                 250                 255
Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val
            260                 265                 270
Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala
        275                 280                 285
Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile
    290                 295                 300
Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr
305                 310                 315                 320
Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His
                325                 330                 335
Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala
            340                 345                 350
Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro
        355                 360                 365
Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu
    370                 375                 380
Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg
385                 390                 395                 400
Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu
                405                 410                 415
Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys
            420                 425                 430
Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu
        435                 440                 445
Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys
    450                 455                 460
Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val
465                 470                 475                 480
Pro Pro Glu Glu Asp Pro Glu
                485

<210> 1365
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1365
Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile
 1               5                  10                  15
Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu
            20                  25                  30
Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile
        35                  40                  45
Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro
    50                  55                  60
Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala
65                  70                  75                  80
Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu
                85                  90                  95
Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe
            100                 105                 110
Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile
        115                 120                 125
Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys
    130                 135                 140
Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu
145                 150                 155                 160
Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val
                165                 170                 175
Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile
            180                 185                 190
Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp
        195                 200                 205
Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala
    210                 215                 220
Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr
225                 230                 235                 240
Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile
                245                 250                 255
Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val
            260                 265                 270
Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala
        275                 280                 285
Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile
    290                 295                 300
Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr
305                 310                 315                 320
Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His
                325                 330                 335
Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala
            340                 345                 350
Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro
        355                 360                 365
Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu
    370                 375                 380
Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg
385                 390                 395                 400
Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu
                405                 410                 415
Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys
            420                 425                 430
Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu
        435                 440                 445
Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys
    450                 455                 460
Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val
465                 470                 475                 480
Pro Pro Glu Glu Asp Pro Glu
                485

<210> 1366
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1366
Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile
 1               5                  10                  15
Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu
            20                  25                  30
Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile
        35                  40                  45
Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro
    50                  55                  60
Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala
65                  70                  75                  80
Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu
                85                  90                  95
Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe
            100                 105                 110
Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile
        115                 120                 125
Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys
    130                 135                 140
Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu
145                 150                 155                 160
Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val
                165                 170                 175
Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile
            180                 185                 190
Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp
        195                 200                 205
Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala
    210                 215                 220
Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr
225                 230                 235                 240
Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile
                245                 250                 255
Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val
            260                 265                 270
Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala
        275                 280                 285
Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile
    290                 295                 300
Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr
305                 310                 315                 320
Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His
                325                 330                 335
Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala
            340                 345                 350
Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro
        355                 360                 365
Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu
    370                 375                 380
Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg
385                 390                 395                 400
Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu
                405                 410                 415
Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys
            420                 425                 430
Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu
        435                 440                 445
Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys
    450                 455                 460
Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val
465                 470                 475                 480
Pro Pro Glu Glu Asp Pro Glu
                485

<210> 1367
<211> 1104
<212> PRT
<213> Homo sapiens

<400> 1367
Met Ala Ala Ala Ala Gly Gly Gly Gly Pro Gly Thr Ala Val Gly Ala
 1               5                  10                  15
Thr Gly Phe Gly Asp Ser Ala Ala Ala Ala Gly Leu Ala Val Tyr Arg
            20                  25                  30
Arg Lys Asp Gly Gly Pro Ala Thr Lys Phe Trp Glu Ser Pro Glu Thr
        35                  40                  45
Val Ser Gln Leu Asp Ser Val Arg Val Trp Leu Gly Lys His Tyr Lys
    50                  55                  60
Lys Tyr Val His Ala Asp Ala Pro Thr Asn Lys Thr Leu Ala Gly Leu
65                  70                  75                  80
Val Val Gln Leu Leu Gln Phe Gln Glu Asp Ala Phe Gly Lys His Val
                85                  90                  95
Thr Asn Pro Ala Phe Thr Lys Leu Pro Ala Lys Cys Phe Met Asp Phe
            100                 105                 110
Lys Ala Gly Gly Ala Leu Cys His Ile Leu Gly Ala Ala Tyr Lys Tyr
        115                 120                 125
Lys Asn Glu Gln Gly Trp Arg Arg Phe Asp Leu Gln Asn Pro Ser Arg
    130                 135                 140
Met Asp Arg Asn Val Glu Met Phe Met Asn Ile Glu Lys Thr Leu Val
145                 150                 155                 160
Gln Asn Asn Cys Leu Thr Arg Pro Asn Ile Tyr Leu Ile Pro Asp Ile
                165                 170                 175
Asp Leu Lys Leu Ala Asn Lys Leu Lys Asp Ile Ile Lys Arg His Gln
            180                 185                 190
Gly Thr Phe Thr Asp Glu Lys Ser Lys Ala Ser His His Ile Tyr Pro
        195                 200                 205
Tyr Ser Ser Ser Gln Asp Asp Glu Glu Trp Leu Arg Pro Val Met Arg
    210                 215                 220
Lys Glu Lys Gln Val Leu Val His Trp Gly Phe Tyr Pro Asp Ser Tyr
225                 230                 235                 240
Asp Thr Trp Val His Ser Asn Asp Val Asp Ala Glu Ile Glu Asp Pro
                245                 250                 255
Pro Ile Pro Glu Lys Pro Trp Lys Val His Val Lys Trp Ile Leu Asp
            260                 265                 270
Thr Asp Ile Phe Asn Glu Trp Met Asn Glu Glu Asp Tyr Glu Val Asp
        275                 280                 285
Glu Asn Arg Lys Pro Val Ser Phe Arg Gln Arg Ile Ser Thr Lys Asn
    290                 295                 300
Glu Glu Pro Val Arg Ser Pro Glu Arg Arg Asp Arg Lys Ala Ser Ala
305                 310                 315                 320
Asn Ala Arg Lys Arg Lys His Ser Pro Ser Pro Pro Pro Pro Thr Pro
                325                 330                 335
Thr Glu Ser Arg Lys Lys Ser Gly Lys Lys Gly Gln Ala Ser Leu Tyr
            340                 345                 350
Gly Lys Arg Arg Ser Gln Lys Glu Glu Asp Glu Gln Glu Asp Leu Thr
        355                 360                 365
Lys Asp Met Glu Asp Pro Thr Pro Val Pro Asn Ile Glu Glu Val Val
    370                 375                 380
Leu Pro Lys Asn Val Asn Leu Lys Lys Asp Ser Glu Asn Thr Pro Val
385                 390                 395                 400
Lys Gly Gly Thr Val Ala Asp Leu Asp Glu Gln Asp Glu Glu Thr Val
                405                 410                 415
Thr Ala Gly Gly Lys Glu Asp Glu Asp Pro Ala Lys Gly Asp Gln Ser
            420                 425                 430
Arg Ser Val Asp Leu Gly Glu Asp Asn Val Thr Glu Gln Thr Asn His
        435                 440                 445
Ile Ile Ile Pro Ser Tyr Ala Ser Trp Phe Asp Tyr Asn Cys Ile His
    450                 455                 460
Val Ile Glu Arg Arg Ala Leu Pro Glu Phe Phe Asn Gly Lys Asn Lys
465                 470                 475                 480
Ser Lys Thr Pro Glu Ile Tyr Leu Ala Tyr Arg Asn Phe Met Ile Asp
                485                 490                 495
Ser Tyr Arg Leu Asn Pro Gln Glu Tyr Leu Thr Ser Thr Ala Cys Arg
            500                 505                 510
Arg Asn Leu Thr Gly Asp Val Cys Ala Val Met Arg Val His Ala Gly
        515                 520                 525
Gly Glu Gln Trp Gly Leu Val Asn Tyr Gln Val Asp Pro Glu Ser Arg
    530                 535                 540
Pro Met Ala Met Gly Pro Pro Pro Thr Pro His Phe Asn Val Leu Ala
545                 550                 555                 560
Asp Thr Pro Leu Ala Cys Ala Ser Asp Leu Arg Ser Pro Gln Val Pro
                565                 570                 575
Ala Ala Gln Gln Met Leu Asn Phe Pro Glu Lys Asn Lys Glu Lys Pro
            580                 585                 590
Val Asp Leu Gln Asn Phe Gly Leu Arg Thr Asp Ile Tyr Ser Lys Lys
        595                 600                 605
Thr Leu Ala Lys Ser Lys Gly Ala Ser Ala Gly Arg Gly Trp Thr Glu
    610                 615                 620
Gln Glu Thr Leu Leu Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp
625                 630                 635                 640
Trp Asn Lys Val Ser Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys
                645                 650                 655
Ile Leu His Phe Leu Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asn
            660                 665                 670
Ser Asp Ala Ser Leu Gly Pro Leu Ala Tyr Gln Pro Val Pro Phe Ser
        675                 680                 685
Gln Ser Gly Asn Pro Val Met Ser Thr Val Ala Phe Leu Ala Ser Val
    690                 695                 700
Val Asp Pro Arg Val Ala Ser Ala Ala Ala Lys Ala Ala Leu Glu Glu
705                 710                 715                 720
Phe Ser Arg Val Arg Glu Glu Val Pro Leu Glu Leu Val Glu Ala His
                725                 730                 735
Val Lys Lys Val Gln Glu Ala Ala Arg Ala Ser Gly Lys Val Asp Pro
            740                 745                 750
Thr Tyr Gly Leu Glu Ser Ser Cys Ile Ala Gly Thr Gly Pro Asp Glu
        755                 760                 765
Pro Glu Lys Leu Glu Gly Ala Glu Glu Glu Lys Met Glu Ala Asp Pro
    770                 775                 780
Asp Gly Gln Gln Pro Glu Lys Ala Glu Asn Lys Val Glu Asn Glu Thr
785                 790                 795                 800
Asp Glu Gly Asp Lys Ala Gln Asp Gly Glu Asn Glu Lys Asn Ser Glu
                805                 810                 815
Lys Glu Gln Asp Ser Glu Val Ser Glu Asp Thr Lys Ser Glu Glu Lys
            820                 825                 830
Glu Thr Glu Glu Asn Lys Glu Leu Ser Ser Thr Cys Lys Glu Arg Glu
        835                 840                 845
Ser Asp Thr Gly Lys Lys Lys Val Glu His Glu Ile Ser Glu Gly Asn
    850                 855                 860
Val Ala Thr Ala Ala Ala Ala Ala Leu Ala Ser Ala Ala Thr Lys Ala
865                 870                 875                 880
Lys His Leu Ala Ala Val Glu Glu Arg Lys Ile Lys Ser Leu Val Ala
                885                 890                 895
Leu Leu Val Glu Thr Gln Met Lys Lys Leu Glu Ile Lys Leu Arg His
            900                 905                 910
Phe Glu Gly Leu Glu Thr Ile Met Asp Arg Glu Lys Glu Ala Leu Glu
        915                 920                 925
Gln Gln Arg Gln Gln Leu Leu Thr Glu Arg Gln Asn Phe His Met Glu
    930                 935                 940
Gln Leu Lys Tyr Ala Glu Leu Arg Ala Arg Gln Gln Met Glu Gln Gln
945                 950                 955                 960
Gln His Gly Gln Asn Pro Gln Gln Ala His Gln His Ser Gly Gly Pro
                965                 970                 975
Gly Leu Ala Pro Leu Gly Ala Ala Gly His Pro Gly Met Met Pro His
            980                 985                 990
Gln Gln Pro Pro Pro Tyr Pro Leu Met His His Gln Met Pro Pro Pro
        995                 1000                1005
His Pro Pro Gln Pro Gly Gln Ile Pro Gly Pro Gly Ser Met Met Pro
    1010                1015                1020
Gly Gln His Met Pro Gly Arg Met Ile Pro Thr Val Ala Ala Asn Ile
1025                1030                1035                1040
His Pro Ser Gly Ser Gly Pro Thr Pro Pro Gly Met Pro Pro Met Pro
                1045                1050                1055
Gly Asn Ile Leu Gly Pro Arg Val Pro Leu Thr Ala Pro Asn Gly Met
            1060                1065                1070
Tyr Pro Pro Pro Pro Gln Gln Gln Pro Pro Pro Pro Pro Pro Ala Asp
        1075                1080                1085
Gly Val Pro Pro Pro Pro Ala Pro Gly Pro Pro Ala Ser Ala Ala Pro
    1090                1095                1100

<210> 1368
<211> 1105
<212> PRT
<213> Homo sapiens

<400> 1368
Met Ala Ala Ala Ala Gly Gly Gly Gly Pro Gly Thr Ala Val Gly Ala
 1               5                  10                  15
Thr Gly Ser Gly Ile Ala Ala Ala Ala Ala Gly Leu Ala Val Tyr Arg
            20                  25                  30
Arg Lys Asp Gly Gly Pro Ala Thr Lys Phe Trp Glu Ser Pro Glu Thr
        35                  40                  45
Val Ser Gln Leu Asp Ser Val Arg Val Trp Leu Gly Lys His Tyr Lys
    50                  55                  60
Lys Tyr Val His Ala Asp Ala Pro Thr Asn Lys Thr Leu Ala Gly Leu
65                  70                  75                  80
Val Val Gln Leu Leu Gln Phe Gln Glu Asp Ala Phe Gly Lys His Val
                85                  90                  95
Thr Asn Pro Ala Phe Thr Lys Leu Pro Ala Lys Cys Phe Met Asp Phe
            100                 105                 110
Lys Ala Gly Gly Ala Leu Cys His Ile Leu Gly Ala Ala Tyr Lys Tyr
        115                 120                 125
Lys Asn Glu Gln Gly Trp Arg Arg Phe Asp Leu Gln Asn Pro Ser Arg
    130                 135                 140
Met Asp Arg Asn Val Glu Met Phe Met Asn Ile Glu Lys Thr Leu Val
145                 150                 155                 160
Gln Asn Asn Cys Leu Thr Arg Pro Asn Ile Tyr Leu Ile Pro Asp Ile
                165                 170                 175
Asp Leu Lys Leu Ala Asn Lys Leu Lys Asp Ile Ile Lys Arg His Gln
            180                 185                 190
Gly Thr Phe Thr Asp Glu Lys Ser Lys Ala Ser His His Ile Tyr Pro
        195                 200                 205
Tyr Ser Ser Ser Gln Asp Asp Glu Glu Trp Leu Arg Pro Val Met Arg
    210                 215                 220
Lys Glu Lys Gln Val Leu Val His Trp Gly Phe Tyr Pro Asp Ser Tyr
225                 230                 235                 240
Asp Thr Trp Val His Ser Asn Asp Val Asp Ala Glu Ile Glu Asp Pro
                245                 250                 255
Pro Ile Pro Glu Lys Pro Trp Lys Val His Val Lys Trp Ile Leu Asp
            260                 265                 270
Thr Asp Ile Phe Asn Glu Trp Met Asn Glu Glu Asp Tyr Glu Val Asp
        275                 280                 285
Glu Asn Arg Lys Pro Val Ser Phe Arg Gln Arg Ile Ser Thr Lys Asn
    290                 295                 300
Glu Glu Pro Val Arg Ser Pro Glu Arg Arg Asp Arg Lys Ala Ser Ala
305                 310                 315                 320
Asn Ala Arg Lys Arg Lys His Ser Pro Ser Pro Pro Pro Pro Thr Pro
                325                 330                 335
Thr Glu Ser Arg Lys Lys Ser Gly Lys Lys Gly Gln Ala Ser Leu Tyr
            340                 345                 350
Gly Lys Arg Arg Ser Gln Lys Glu Glu Asp Glu Gln Glu Asp Leu Thr
        355                 360                 365
Lys Asp Met Glu Asp Pro Thr Pro Val Pro Asn Ile Glu Glu Val Val
    370                 375                 380
Leu Pro Lys Asn Val Asn Leu Lys Lys Asp Ser Glu Asn Thr Pro Val
385                 390                 395                 400
Lys Gly Gly Thr Val Ala Asp Leu Asp Glu Gln Asp Glu Glu Thr Val
                405                 410                 415
Thr Ala Gly Gly Lys Glu Asp Glu Asp Pro Ala Lys Gly Asp Gln Ser
            420                 425                 430
Arg Ser Val Asp Leu Gly Glu Asp Asn Val Thr Glu Gln Thr Asn His
        435                 440                 445
Ile Ile Ile Pro Ser Tyr Ala Ser Trp Phe Asp Tyr Asn Cys Ile His
    450                 455                 460
Val Ile Glu Arg Arg Ala Leu Pro Glu Phe Phe Asn Gly Lys Asn Lys
465                 470                 475                 480
Ser Lys Thr Pro Glu Ile Tyr Leu Ala Tyr Arg Asn Phe Met Ile Asp
                485                 490                 495
Thr Tyr Arg Leu Asn Pro Gln Glu Tyr Leu Thr Ser Thr Ala Cys Arg
            500                 505                 510
Arg Asn Leu Thr Gly Asp Val Cys Ala Val Met Arg Val His Ala Phe
        515                 520                 525
Leu Glu Gln Trp Gly Leu Val Asn Tyr Gln Val Asp Pro Glu Ser Arg
    530                 535                 540
Pro Met Ala Met Gly Pro Pro Pro Thr Pro His Phe Asn Val Leu Ala
545                 550                 555                 560
Asp Thr Pro Ser Gly Leu Val Pro Leu His Leu Arg Ser Pro Gln Val
                565                 570                 575
Pro Ala Ala Gln Gln Met Leu Asn Phe Pro Glu Lys Asn Lys Glu Lys
            580                 585                 590
Pro Val Asp Leu Gln Asn Phe Gly Leu Arg Thr Asp Ile Tyr Ser Lys
        595                 600                 605
Lys Thr Leu Ala Lys Ser Lys Gly Ala Ser Ala Gly Arg Glu Trp Thr
    610                 615                 620
Glu Gln Glu Thr Leu Leu Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp
625                 630                 635                 640
Asp Trp Asn Lys Val Ser Glu His Val Gly Ser Arg Thr Gln Asp Glu
                645                 650                 655
Cys Ile Leu His Phe Leu Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu
            660                 665                 670
Asn Ser Asp Ala Ser Leu Gly Pro Leu Ala Tyr Gln Pro Val Pro Phe
        675                 680                 685
Ser Gln Ser Gly Asn Pro Val Met Ser Thr Val Ala Phe Leu Ala Ser
    690                 695                 700
Val Val Asp Pro Arg Val Ala Ser Ala Ala Ala Lys Ala Ala Leu Glu
705                 710                 715                 720
Glu Phe Ser Arg Val Arg Glu Glu Val Pro Leu Glu Leu Val Glu Ala
                725                 730                 735
His Val Lys Lys Val Gln Glu Ala Ala Arg Ala Ser Gly Lys Val Asp
            740                 745                 750
Pro Thr Tyr Gly Leu Glu Ser Ser Cys Ile Ala Gly Thr Gly Pro Asp
        755                 760                 765
Glu Pro Glu Lys Leu Glu Gly Ala Glu Glu Glu Lys Met Glu Ala Asp
    770                 775                 780
Pro Asp Gly Gln Gln Pro Glu Lys Ala Glu Asn Lys Val Glu Asn Glu
785                 790                 795                 800
Thr Asp Glu Gly Asp Lys Ala Gln Asp Gly Glu Asn Glu Lys Asn Ser
                805                 810                 815
Glu Lys Glu Gln Asp Ser Glu Val Ser Glu Asp Thr Lys Ser Glu Glu
            820                 825                 830
Lys Glu Thr Glu Glu Asn Lys Glu Leu Thr Asp Thr Cys Lys Glu Arg
        835                 840                 845
Glu Ser Asp Thr Gly Lys Lys Lys Val Glu His Glu Ile Ser Glu Gly
    850                 855                 860
Asn Val Ala Thr Ala Ala Ala Ala Ala Leu Ala Ser Ala Ala Thr Lys
865                 870                 875                 880
Ala Lys His Leu Ala Ala Val Glu Glu Arg Lys Ile Lys Ser Leu Val
                885                 890                 895
Ala Leu Leu Val Glu Thr Gln Met Lys Lys Leu Glu Ile Lys Leu Arg
            900                 905                 910
His Phe Glu Glu Leu Glu Thr Ile Met Asp Arg Glu Lys Glu Ala Leu
        915                 920                 925
Glu Gln Gln Arg Gln Gln Leu Leu Thr Glu Arg Gln Asn Phe His Met
    930                 935                 940
Glu Gln Leu Lys Tyr Ala Glu Leu Arg Ala Arg Gln Gln Met Glu Gln
945                 950                 955                 960
Gln Gln His Gly Gln Asn Pro Gln Gln Ala His Gln His Ser Gly Gly
                965                 970                 975
Pro Gly Leu Ala Pro Leu Gly Ala Ala Gly His Pro Gly Met Met Pro
            980                 985                 990
His Gln Gln Pro Pro Pro Tyr Pro Leu Met His His Gln Met Pro Pro
        995                 1000                1005
Pro His Pro Pro Gln Pro Gly Gln Ile Pro Gly Pro Gly Ser Met Met
    1010                1015                1020
Pro Gly Gln His Met Pro Gly Arg Met Ile Pro Thr Val Ala Ala Asn
1025                1030                1035                1040
Ile His Pro Ser Gly Ser Gly Pro Thr Pro Pro Gly Met Pro Pro Met
                1045                1050                1055
Pro Gly Asn Ile Leu Gly Pro Arg Val Pro Leu Thr Ala Pro Asn Gly
            1060                1065                1070
Met Tyr Pro Pro Pro Pro Gln Gln Gln Pro Pro Pro Pro Pro Pro Ala
        1075                1080                1085
Asp Gly Val Pro Pro Pro Pro Ala Pro Gly Pro Pro Ala Ser Ala Ala
    1090                1095                1100
Pro
1105

<210> 1369
<211> 1104
<212> PRT
<213> Homo sapiens

<400> 1369
Met Ala Ala Ala Ala Gly Gly Gly Gly Pro Gly Thr Ala Val Gly Ala
 1               5                  10                  15
Thr Gly Phe Gly Asp Ser Ala Ala Ala Ala Gly Leu Ala Val Tyr Arg
            20                  25                  30
Arg Lys Asp Gly Gly Pro Ala Thr Lys Phe Trp Glu Ser Pro Glu Thr
        35                  40                  45
Val Ser Gln Leu Asp Ser Val Arg Val Trp Leu Gly Lys His Tyr Lys
    50                  55                  60
Lys Tyr Val His Ala Asp Ala Pro Thr Asn Lys Thr Leu Ala Gly Leu
65                  70                  75                  80
Val Val Gln Leu Leu Gln Phe Gln Glu Asp Ala Phe Gly Lys His Val
                85                  90                  95
Thr Asn Pro Ala Phe Thr Lys Leu Pro Ala Lys Cys Phe Met Asp Phe
            100                 105                 110
Lys Ala Gly Gly Ala Leu Cys His Ile Leu Gly Ala Ala Tyr Lys Tyr
        115                 120                 125
Lys Asn Glu Gln Gly Trp Arg Arg Phe Asp Leu Gln Asn Pro Ser Arg
    130                 135                 140
Met Asp Arg Asn Val Glu Met Phe Met Asn Ile Glu Lys Thr Leu Val
145                 150                 155                 160
Gln Asn Asn Cys Leu Thr Arg Pro Asn Ile Tyr Leu Ile Pro Asp Ile
                165                 170                 175
Asp Leu Lys Leu Ala Asn Lys Leu Lys Asp Ile Ile Lys Arg His Gln
            180                 185                 190
Gly Thr Phe Thr Asp Glu Lys Ser Lys Ala Ser His His Ile Tyr Pro
        195                 200                 205
Tyr Ser Ser Ser Gln Asp Asp Glu Glu Trp Leu Arg Pro Val Met Arg
    210                 215                 220
Lys Glu Lys Gln Val Leu Val His Trp Gly Phe Tyr Pro Asp Ser Tyr
225                 230                 235                 240
Asp Thr Trp Val His Ser Asn Asp Val Asp Ala Glu Ile Glu Asp Pro
                245                 250                 255
Pro Ile Pro Glu Lys Pro Trp Lys Val His Val Lys Trp Ile Leu Asp
            260                 265                 270
Thr Asp Ile Phe Asn Glu Trp Met Asn Glu Glu Asp Tyr Glu Val Asp
        275                 280                 285
Glu Asn Arg Lys Pro Val Ser Phe Arg Gln Arg Ile Ser Thr Lys Asn
    290                 295                 300
Glu Glu Pro Val Arg Ser Pro Glu Arg Arg Asp Arg Lys Ala Ser Ala
305                 310                 315                 320
Asn Ala Arg Lys Arg Lys His Ser Pro Ser Pro Pro Pro Pro Thr Pro
                325                 330                 335
Thr Glu Ser Arg Lys Lys Ser Gly Lys Lys Gly Gln Ala Ser Leu Tyr
            340                 345                 350
Gly Lys Arg Arg Ser Gln Lys Glu Glu Asp Glu Gln Glu Asp Leu Thr
        355                 360                 365
Lys Asp Met Glu Asp Pro Thr Pro Val Pro Asn Ile Glu Glu Val Val
    370                 375                 380
Leu Pro Lys Asn Val Asn Leu Lys Lys Asp Ser Glu Asn Thr Pro Val
385                 390                 395                 400
Lys Gly Gly Thr Val Ala Asp Leu Asp Glu Gln Asp Glu Glu Thr Val
                405                 410                 415
Thr Ala Gly Gly Lys Glu Asp Glu Asp Pro Ala Lys Gly Asp Gln Ser
            420                 425                 430
Arg Ser Val Asp Leu Gly Glu Asp Asn Val Thr Glu Gln Thr Asn His
        435                 440                 445
Ile Ile Ile Pro Ser Tyr Ala Ser Trp Phe Asp Tyr Asn Cys Ile His
    450                 455                 460
Val Ile Glu Arg Arg Ala Leu Pro Glu Phe Phe Asn Gly Lys Asn Lys
465                 470                 475                 480
Ser Lys Thr Pro Glu Ile Tyr Leu Ala Tyr Arg Asn Phe Met Ile Asp
                485                 490                 495
Ser Tyr Arg Leu Asn Pro Gln Glu Tyr Leu Thr Ser Thr Ala Cys Arg
            500                 505                 510
Arg Asn Leu Thr Gly Asp Val Cys Ala Val Met Arg Val His Ala Gly
        515                 520                 525
Gly Glu Gln Trp Gly Leu Val Asn Tyr Gln Val Asp Pro Glu Ser Arg
    530                 535                 540
Pro Met Ala Met Gly Pro Pro Pro Thr Pro His Phe Asn Val Leu Ala
545                 550                 555                 560
Asp Thr Pro Leu Ala Cys Ala Ser Asp Leu Arg Ser Pro Gln Val Pro
                565                 570                 575
Ala Ala Gln Gln Met Leu Asn Phe Pro Glu Lys Asn Lys Glu Lys Pro
            580                 585                 590
Val Asp Leu Gln Asn Phe Gly Leu Arg Thr Asp Ile Tyr Ser Lys Lys
        595                 600                 605
Thr Leu Ala Lys Ser Lys Gly Ala Ser Ala Gly Arg Gly Trp Thr Glu
    610                 615                 620
Gln Glu Thr Leu Leu Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp
625                 630                 635                 640
Trp Asn Lys Val Ser Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys
                645                 650                 655
Ile Leu His Phe Leu Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asn
            660                 665                 670
Ser Asp Ala Ser Leu Gly Pro Leu Ala Tyr Gln Pro Val Pro Phe Ser
        675                 680                 685
Gln Ser Gly Asn Pro Val Met Ser Thr Val Ala Phe Leu Ala Ser Val
    690                 695                 700
Val Asp Pro Arg Val Ala Ser Ala Ala Ala Lys Ala Ala Leu Glu Glu
705                 710                 715                 720
Phe Ser Arg Val Arg Glu Glu Val Pro Leu Glu Leu Val Glu Ala His
                725                 730                 735
Val Lys Lys Val Gln Glu Ala Ala Arg Ala Ser Gly Lys Val Asp Pro
            740                 745                 750
Thr Tyr Gly Leu Glu Ser Ser Cys Ile Ala Gly Thr Gly Pro Asp Glu
        755                 760                 765
Pro Glu Lys Leu Glu Gly Ala Glu Glu Glu Lys Met Glu Ala Asp Pro
    770                 775                 780
Asp Gly Gln Gln Pro Glu Lys Ala Glu Asn Lys Val Glu Asn Glu Thr
785                 790                 795                 800
Asp Glu Gly Asp Lys Ala Gln Asp Gly Glu Asn Glu Lys Asn Ser Glu
                805                 810                 815
Lys Glu Gln Asp Ser Glu Val Ser Glu Asp Thr Lys Ser Glu Glu Lys
            820                 825                 830
Glu Thr Glu Glu Asn Lys Glu Leu Ser Ser Thr Cys Lys Glu Arg Glu
        835                 840                 845
Ser Asp Thr Gly Lys Lys Lys Val Glu His Glu Ile Ser Glu Gly Asn
    850                 855                 860
Val Ala Thr Ala Ala Ala Ala Ala Leu Ala Ser Ala Ala Thr Lys Ala
865                 870                 875                 880
Lys His Leu Ala Ala Val Glu Glu Arg Lys Ile Lys Ser Leu Val Ala
                885                 890                 895
Leu Leu Val Glu Thr Gln Met Lys Lys Leu Glu Ile Lys Leu Arg His
            900                 905                 910
Phe Glu Gly Leu Glu Thr Ile Met Asp Arg Glu Lys Glu Ala Leu Glu
        915                 920                 925
Gln Gln Arg Gln Gln Leu Leu Thr Glu Arg Gln Asn Phe His Met Glu
    930                 935                 940
Gln Leu Lys Tyr Ala Glu Leu Arg Ala Arg Gln Gln Met Glu Gln Gln
945                 950                 955                 960
Gln His Gly Gln Asn Pro Gln Gln Ala His Gln His Ser Gly Gly Pro
                965                 970                 975
Gly Leu Ala Pro Leu Gly Ala Ala Gly His Pro Gly Met Met Pro His
            980                 985                 990
Gln Gln Pro Pro Pro Tyr Pro Leu Met His His Gln Met Pro Pro Pro
        995                 1000                1005
His Pro Pro Gln Pro Gly Gln Ile Pro Gly Pro Gly Ser Met Met Pro
    1010                1015                1020
Gly Gln His Met Pro Gly Arg Met Ile Pro Thr Val Ala Ala Asn Ile
1025                1030                1035                1040
His Pro Ser Gly Ser Gly Pro Thr Pro Pro Gly Met Pro Pro Met Pro
                1045                1050                1055
Gly Asn Ile Leu Gly Pro Arg Val Pro Leu Thr Ala Pro Asn Gly Met
            1060                1065                1070
Tyr Pro Pro Pro Pro Gln Gln Gln Pro Pro Pro Pro Pro Pro Ala Asp
        1075                1080                1085
Gly Val Pro Pro Pro Pro Ala Pro Gly Pro Pro Ala Ser Ala Ala Pro
    1090                1095                1100

<210> 1370
<211> 1104
<212> PRT
<213> Homo sapiens

<400> 1370
Met Ala Ala Ala Ala Gly Gly Gly Gly Pro Gly Thr Ala Val Gly Ala
 1               5                  10                  15
Thr Gly Phe Gly Asp Ser Ala Ala Ala Ala Gly Leu Ala Val Tyr Arg
            20                  25                  30
Arg Lys Asp Gly Gly Pro Ala Thr Lys Phe Trp Glu Ser Pro Glu Thr
        35                  40                  45
Val Ser Gln Leu Asp Ser Val Arg Val Trp Leu Gly Lys His Tyr Lys
    50                  55                  60
Lys Tyr Val His Ala Asp Ala Pro Thr Asn Lys Thr Leu Ala Gly Leu
65                  70                  75                  80
Val Val Gln Leu Leu Gln Phe Gln Glu Asp Ala Phe Gly Lys His Val
                85                  90                  95
Thr Asn Pro Ala Phe Thr Lys Leu Pro Ala Lys Cys Phe Met Asp Phe
            100                 105                 110
Lys Ala Gly Gly Ala Leu Cys His Ile Leu Gly Ala Ala Tyr Lys Tyr
        115                 120                 125
Lys Asn Glu Gln Gly Trp Arg Arg Phe Asp Leu Gln Asn Pro Ser Arg
    130                 135                 140
Met Asp Arg Asn Val Glu Met Phe Met Asn Ile Glu Lys Thr Leu Val
145                 150                 155                 160
Gln Asn Asn Cys Leu Thr Arg Pro Asn Ile Tyr Leu Ile Pro Asp Ile
                165                 170                 175
Asp Leu Lys Leu Ala Asn Lys Leu Lys Asp Ile Ile Lys Arg His Gln
            180                 185                 190
Gly Thr Phe Thr Asp Glu Lys Ser Lys Ala Ser His His Ile Tyr Pro
        195                 200                 205
Tyr Ser Ser Ser Gln Asp Asp Glu Glu Trp Leu Arg Pro Val Met Arg
    210                 215                 220
Lys Glu Lys Gln Val Leu Val His Trp Gly Phe Tyr Pro Asp Ser Tyr
225                 230                 235                 240
Asp Thr Trp Val His Ser Asn Asp Val Asp Ala Glu Ile Glu Asp Pro
                245                 250                 255
Pro Ile Pro Glu Lys Pro Trp Lys Val His Val Lys Trp Ile Leu Asp
            260                 265                 270
Thr Asp Ile Phe Asn Glu Trp Met Asn Glu Glu Asp Tyr Glu Val Asp
        275                 280                 285
Glu Asn Arg Lys Pro Val Ser Phe Arg Gln Arg Ile Ser Thr Lys Asn
    290                 295                 300
Glu Glu Pro Val Arg Ser Pro Glu Arg Arg Asp Arg Lys Ala Ser Ala
305                 310                 315                 320
Asn Ala Arg Lys Arg Lys His Ser Pro Ser Pro Pro Pro Pro Thr Pro
                325                 330                 335
Thr Glu Ser Arg Lys Lys Ser Gly Lys Lys Gly Gln Ala Ser Leu Tyr
            340                 345                 350
Gly Lys Arg Arg Ser Gln Lys Glu Glu Asp Glu Gln Glu Asp Leu Thr
        355                 360                 365
Lys Asp Met Glu Asp Pro Thr Pro Val Pro Asn Ile Glu Glu Val Val
    370                 375                 380
Leu Pro Lys Asn Val Asn Leu Lys Lys Asp Ser Glu Asn Thr Pro Val
385                 390                 395                 400
Lys Gly Gly Thr Val Ala Asp Leu Asp Glu Gln Asp Glu Glu Thr Val
                405                 410                 415
Thr Ala Gly Gly Lys Glu Asp Glu Asp Pro Ala Lys Gly Asp Gln Ser
            420                 425                 430
Arg Ser Val Asp Leu Gly Glu Asp Asn Val Thr Glu Gln Thr Asn His
        435                 440                 445
Ile Ile Ile Pro Ser Tyr Ala Ser Trp Phe Asp Tyr Asn Cys Ile His
    450                 455                 460
Val Ile Glu Arg Arg Ala Leu Pro Glu Phe Phe Asn Gly Lys Asn Lys
465                 470                 475                 480
Ser Lys Thr Pro Glu Ile Tyr Leu Ala Tyr Arg Asn Phe Met Ile Asp
                485                 490                 495
Ser Tyr Arg Leu Asn Pro Gln Glu Tyr Leu Thr Ser Thr Ala Cys Arg
            500                 505                 510
Arg Asn Leu Thr Gly Asp Val Cys Ala Val Met Arg Val His Ala Gly
        515                 520                 525
Gly Glu Gln Trp Gly Leu Val Asn Tyr Gln Val Asp Pro Glu Ser Arg
    530                 535                 540
Pro Met Ala Met Gly Pro Pro Pro Thr Pro His Phe Asn Val Leu Ala
545                 550                 555                 560
Asp Thr Pro Leu Ala Cys Ala Ser Asp Leu Arg Ser Pro Gln Val Pro
                565                 570                 575
Ala Ala Gln Gln Met Leu Asn Phe Pro Glu Lys Asn Lys Glu Lys Pro
            580                 585                 590
Val Asp Leu Gln Asn Phe Gly Leu Arg Thr Asp Ile Tyr Ser Lys Lys
        595                 600                 605
Thr Leu Ala Lys Ser Lys Gly Ala Ser Ala Gly Arg Gly Trp Thr Glu
    610                 615                 620
Gln Glu Thr Leu Leu Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp
625                 630                 635                 640
Trp Asn Lys Val Ser Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys
                645                 650                 655
Ile Leu His Phe Leu Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asn
            660                 665                 670
Ser Asp Ala Ser Leu Gly Pro Leu Ala Tyr Gln Pro Val Pro Phe Ser
        675                 680                 685
Gln Ser Gly Asn Pro Val Met Ser Thr Val Ala Phe Leu Ala Ser Val
    690                 695                 700
Val Asp Pro Arg Val Ala Ser Ala Ala Ala Lys Ala Ala Leu Glu Glu
705                 710                 715                 720
Phe Ser Arg Val Arg Glu Glu Val Pro Leu Glu Leu Val Glu Ala His
                725                 730                 735
Val Lys Lys Val Gln Glu Ala Ala Arg Ala Ser Gly Lys Val Asp Pro
            740                 745                 750
Thr Tyr Gly Leu Glu Ser Ser Cys Ile Ala Gly Thr Gly Pro Asp Glu
        755                 760                 765
Pro Glu Lys Leu Glu Gly Ala Glu Glu Glu Lys Met Glu Ala Asp Pro
    770                 775                 780
Asp Gly Gln Gln Pro Glu Lys Ala Glu Asn Lys Val Glu Asn Glu Thr
785                 790                 795                 800
Asp Glu Gly Asp Lys Ala Gln Asp Gly Glu Asn Glu Lys Asn Ser Glu
                805                 810                 815
Lys Glu Gln Asp Ser Glu Val Ser Glu Asp Thr Lys Ser Glu Glu Lys
            820                 825                 830
Glu Thr Glu Glu Asn Lys Glu Leu Ser Ser Thr Cys Lys Glu Arg Glu
        835                 840                 845
Ser Asp Thr Gly Lys Lys Lys Val Glu His Glu Ile Ser Glu Gly Asn
    850                 855                 860
Val Ala Thr Ala Ala Ala Ala Ala Leu Ala Ser Ala Ala Thr Lys Ala
865                 870                 875                 880
Lys His Leu Ala Ala Val Glu Glu Arg Lys Ile Lys Ser Leu Val Ala
                885                 890                 895
Leu Leu Val Glu Thr Gln Met Lys Lys Leu Glu Ile Lys Leu Arg His
            900                 905                 910
Phe Glu Gly Leu Glu Thr Ile Met Asp Arg Glu Lys Glu Ala Leu Glu
        915                 920                 925
Gln Gln Arg Gln Gln Leu Leu Thr Glu Arg Gln Asn Phe His Met Glu
    930                 935                 940
Gln Leu Lys Tyr Ala Glu Leu Arg Ala Arg Gln Gln Met Glu Gln Gln
945                 950                 955                 960
Gln His Gly Gln Asn Pro Gln Gln Ala His Gln His Ser Gly Gly Pro
                965                 970                 975
Gly Leu Ala Pro Leu Gly Ala Ala Gly His Pro Gly Met Met Pro His
            980                 985                 990
Gln Gln Pro Pro Pro Tyr Pro Leu Met His His Gln Met Pro Pro Pro
        995                 1000                1005
His Pro Pro Gln Pro Gly Gln Ile Pro Gly Pro Gly Ser Met Met Pro
    1010                1015                1020
Gly Gln His Met Pro Gly Arg Met Ile Pro Thr Val Ala Ala Asn Ile
1025                1030                1035                1040
His Pro Ser Gly Ser Gly Pro Thr Pro Pro Gly Met Pro Pro Met Pro
                1045                1050                1055
Gly Asn Ile Leu Gly Pro Arg Val Pro Leu Thr Ala Pro Asn Gly Met
            1060                1065                1070
Tyr Pro Pro Pro Pro Gln Gln Gln Pro Pro Pro Pro Pro Pro Ala Asp
        1075                1080                1085
Gly Val Pro Pro Pro Pro Ala Pro Gly Pro Pro Ala Ser Ala Ala Pro
    1090                1095                1100

<210> 1371
<211> 468
<212> PRT
<213> Homo sapiens

<400> 1371
His Glu Ala Gln Asp Glu Gly Gly His Cys Trp Gly Ser Ala Ser Gly
 1               5                  10                  15
Arg Arg Thr Leu Arg Arg Arg Arg Ala Ala Gln Arg Cys Gly Gly Gly
            20                  25                  30
Ala Arg Ala Asp Ala Gly Pro Met Ala Arg Thr Thr Ser Gln Leu Tyr
        35                  40                  45
Asp Ala Val Pro Ile Gln Ser Ser Val Val Leu Cys Ser Cys Pro Ser
    50                  55                  60
Pro Ser Met Val Arg Thr Gln Thr Glu Ser Ser Thr Pro Pro Gly Ile
65                  70                  75                  80
Pro Gly Gly Ser Arg Gln Gly Pro Ala Met Asp Gly Thr Ala Ala Glu
                85                  90                  95
Pro Arg Pro Gly Ala Gly Ser Leu Gln His Ala Gln Pro Pro Pro Gln
            100                 105                 110
Pro Arg Lys Lys Arg Pro Glu Asp Phe Lys Phe Gly Lys Ile Leu Gly
        115                 120                 125
Glu Gly Ser Phe Ser Thr Val Val Leu Ala Arg Glu Leu Ala Thr Ser
    130                 135                 140
Arg Glu Tyr Ala Thr Arg Ala Asn Ser Phe Val Gly Thr Ala Gln Tyr
145                 150                 155                 160
Val Ser Pro Glu Leu Leu Thr Glu Lys Ser Ala Cys Lys Ser Ser Asp
                165                 170                 175
Leu Trp Ala Leu Gly Cys Ile Ile Tyr Gln Leu Val Ala Gly Leu Pro
            180                 185                 190
Pro Phe Arg Ala Gly Asn Glu Tyr Leu Ile Phe Gln Lys Ile Ile Lys
        195                 200                 205
Leu Glu Tyr Asp Phe Pro Glu Lys Phe Phe Pro Lys Ala Arg Asp Leu
    210                 215                 220
Val Glu Lys Leu Leu Val Leu Asp Ala Thr Lys Arg Leu Gly Cys Glu
225                 230                 235                 240
Glu Met Glu Gly Tyr Gly Pro Leu Lys Ala His Pro Phe Phe Glu Ser
                245                 250                 255
Val Thr Trp Glu Asn Leu His Gln Gln Thr Pro Pro Lys Leu Thr Ala
            260                 265                 270
Tyr Leu Pro Ala Met Ser Glu Asp Asp Glu Asp Cys Tyr Gly Asn Tyr
        275                 280                 285
Asp Asn Leu Leu Ser Gln Phe Gly Cys Met Gln Val Ser Ser Ser Ser
    290                 295                 300
Ser Ser His Ser Leu Ser Ala Ser Asp Thr Gly Leu Pro Gln Arg Ser
305                 310                 315                 320
Gly Ser Asn Ile Glu Gln Tyr Ile His Asp Leu Asp Ser Asn Ser Phe
                325                 330                 335
Glu Leu Asp Leu Gln Phe Ser Glu Asp Glu Lys Arg Leu Leu Leu Glu
            340                 345                 350
Lys Gln Ala Gly Gly Asn Pro Trp His Gln Phe Val Glu Asn Asn Leu
        355                 360                 365
Ile Leu Lys Met Gly Pro Val Asp Lys Arg Lys Gly Leu Phe Ala Arg
    370                 375                 380
Arg Arg Gln Leu Leu Leu Thr Glu Gly Pro His Leu Tyr Tyr Val Asp
385                 390                 395                 400
Pro Val Asn Lys Val Leu Lys Gly Glu Ile Pro Trp Ser Gln Glu Leu
                405                 410                 415
Arg Pro Glu Ala Lys Asn Phe Lys Thr Phe Phe Val His Thr Pro Asn
            420                 425                 430
Arg Thr Tyr Tyr Leu Met Asp Pro Ser Gly Asn Ala His Lys Trp Cys
        435                 440                 445
Arg Lys Ile Gln Glu Val Trp Arg Gln Arg Tyr Gln Ser His Pro Asp
    450                 455                 460
Ala Ala Val Gln
465

<210> 1372
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1372
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555

<210> 1373
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1373
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555

<210> 1374
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1374
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555

<210> 1375
<211> 319
<212> PRT
<213> Homo sapiens

<400> 1375
Arg Ala Asn Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu
 1               5                  10                  15
Leu Thr Glu Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly
            20                  25                  30
Cys Ile Ile Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly
        35                  40                  45
Asn Glu Tyr Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe
    50                  55                  60
Pro Glu Lys Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu
65                  70                  75                  80
Val Leu Asp Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr
                85                  90                  95
Gly Pro Leu Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn
            100                 105                 110
Leu His Gln Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met
        115                 120                 125
Ser Glu Asp Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser
    130                 135                 140
Gln Phe Gly Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu
145                 150                 155                 160
Ser Ala Ser Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu
                165                 170                 175
Gln Tyr Ile His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln
            180                 185                 190
Phe Ser Glu Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly
        195                 200                 205
Asn Pro Trp His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly
    210                 215                 220
Pro Val Asp Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu
225                 230                 235                 240
Leu Thr Glu Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val
                245                 250                 255
Leu Lys Gly Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys
            260                 265                 270
Asn Phe Lys Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu
        275                 280                 285
Met Asp Pro Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu
    290                 295                 300
Val Trp Arg Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
305                 310                 315

<210> 1376
<211> 104
<212> PRT
<213> Homo sapiens

<400> 1376
Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp His Gln Phe Val Glu Asn
 1               5                  10                  15
Asn Leu Ile Leu Lys Met Gly Pro Val Asp Lys Arg Lys Gly Leu Phe
            20                  25                  30
Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu Gly Pro His Leu Tyr Tyr
        35                  40                  45
Val Asp Pro Val Asn Lys Val Leu Lys Gly Glu Ile Pro Trp Ser Gln
    50                  55                  60
Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys Thr Phe Phe Val His Thr
65                  70                  75                  80
Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro Ser Gly Asn Ala His Lys
                85                  90                  95
Trp Cys Arg Lys Ile Gln Glu Val
            100

<210> 1377
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1377
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555

<210> 1378
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1378
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555

<210> 1379
<211> 535
<212> PRT
<213> Homo sapiens

<400> 1379
Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln Thr Glu Ser Ser Thr
 1               5                  10                  15
Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly Pro Ala Met Asp Gly
            20                  25                  30
Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser Leu Gln His Ala Gln
        35                  40                  45
Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu Asp Phe Lys Phe Gly
    50                  55                  60
Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val Val Leu Ala Arg Glu
65                  70                  75                  80
Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile Leu Glu Lys Arg His
                85                  90                  95
Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr Arg Glu Arg Asp Val
            100                 105                 110
Met Ser Arg Leu Asp His Pro Phe Phe Val Lys Leu Tyr Phe Thr Phe
        115                 120                 125
Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser Tyr Ala Lys Asn Gly
    130                 135                 140
Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser Phe Asp Glu Thr Cys
145                 150                 155                 160
Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His
                165                 170                 175
Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu
            180                 185                 190
Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe Gly Thr Ala Lys Val
        195                 200                 205
Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn Ser Phe Val Gly Thr
    210                 215                 220
Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu Lys Ser Ala Cys Lys
225                 230                 235                 240
Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile Tyr Gln Leu Val Ala
                245                 250                 255
Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr Leu Ile Phe Gln Lys
            260                 265                 270
Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys Phe Phe Pro Lys Ala
        275                 280                 285
Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp Ala Thr Lys Arg Leu
    290                 295                 300
Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu Lys Ala His Pro Phe
305                 310                 315                 320
Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln Gln Thr Pro Pro Lys
                325                 330                 335
Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp Asp Glu Asp Cys Tyr
            340                 345                 350
Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly Cys Met Gln Val Ser
        355                 360                 365
Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser Asp Thr Gly Leu Pro
    370                 375                 380
Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile His Asp Leu Asp Ser
385                 390                 395                 400
Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu Asp Glu Lys Arg Leu
                405                 410                 415
Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp His Gln Phe Val Glu
            420                 425                 430
Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp Lys Arg Lys Gly Leu
        435                 440                 445
Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu Gly Pro His Leu Tyr
    450                 455                 460
Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly Glu Ile Pro Trp Ser
465                 470                 475                 480
Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys Thr Phe Phe Val His
                485                 490                 495
Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro Ser Gly Asn Ala His
            500                 505                 510
Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg Gln Arg Tyr Gln Ser
        515                 520                 525
His Pro Asp Ala Ala Val Gln
    530                 535

<210> 1380
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1380
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555

<210> 1381
<211> 506
<212> PRT
<213> Homo sapiens

<400> 1381
Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser Leu Gln
 1               5                  10                  15
His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu Asp Phe
            20                  25                  30
Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val Val Leu
        35                  40                  45
Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile Leu Glu
    50                  55                  60
Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr Arg Glu
65                  70                  75                  80
Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys Leu Tyr
                85                  90                  95
Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser Tyr Ala
            100                 105                 110
Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser Phe Asp
        115                 120                 125
Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala Leu Glu
    130                 135                 140
Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn
145                 150                 155                 160
Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe Gly Thr
                165                 170                 175
Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn Ser Phe
            180                 185                 190
Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu Lys Ser
        195                 200                 205
Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile Tyr Gln
    210                 215                 220
Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr Leu Ile
225                 230                 235                 240
Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys Phe Phe
                245                 250                 255
Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp Ala Thr
            260                 265                 270
Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu Lys Ala
        275                 280                 285
His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln Gln Thr
    290                 295                 300
Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp Asp Glu
305                 310                 315                 320
Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly Cys Met
                325                 330                 335
Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser Asp Thr
            340                 345                 350
Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile His Asp
        355                 360                 365
Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu Asp Glu
    370                 375                 380
Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp His Gln
385                 390                 395                 400
Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp Lys Arg
                405                 410                 415
Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu Gly Pro
            420                 425                 430
His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly Glu Ile
        435                 440                 445
Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys Thr Phe
    450                 455                 460
Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro Ser Gly
465                 470                 475                 480
Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg Gln Arg
                485                 490                 495
Tyr Gln Ser His Pro Asp Ala Ala Val Gln
            500                 505

<210> 1382
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1382
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555

<210> 1383
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1383
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555

<210> 1384
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1384
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555

<210> 1385
<211> 468
<212> PRT
<213> Homo sapiens

<400> 1385
His Glu Ala Gln Asp Glu Gly Gly His Cys Trp Gly Ser Ala Ser Gly
 1               5                  10                  15
Arg Arg Thr Leu Arg Arg Arg Arg Ala Ala Gln Arg Cys Gly Gly Gly
            20                  25                  30
Ala Arg Ala Asp Ala Gly Pro Met Ala Arg Thr Thr Ser Gln Leu Tyr
        35                  40                  45
Asp Ala Val Pro Ile Gln Ser Ser Val Val Leu Cys Ser Cys Pro Ser
    50                  55                  60
Pro Ser Met Val Arg Thr Gln Thr Glu Ser Ser Thr Pro Pro Gly Ile
65                  70                  75                  80
Pro Gly Gly Ser Arg Gln Gly Pro Ala Met Asp Gly Thr Ala Ala Glu
                85                  90                  95
Pro Arg Pro Gly Ala Gly Ser Leu Gln His Ala Gln Pro Pro Pro Gln
            100                 105                 110
Pro Arg Lys Lys Arg Pro Glu Asp Phe Lys Phe Gly Lys Ile Leu Gly
        115                 120                 125
Glu Gly Ser Phe Ser Thr Val Val Leu Ala Arg Glu Leu Ala Thr Ser
    130                 135                 140
Arg Glu Tyr Ala Thr Arg Ala Asn Ser Phe Val Gly Thr Ala Gln Tyr
145                 150                 155                 160
Val Ser Pro Glu Leu Leu Thr Glu Lys Ser Ala Cys Lys Ser Ser Asp
                165                 170                 175
Leu Trp Ala Leu Gly Cys Ile Ile Tyr Gln Leu Val Ala Gly Leu Pro
            180                 185                 190
Pro Phe Arg Ala Gly Asn Glu Tyr Leu Ile Phe Gln Lys Ile Ile Lys
        195                 200                 205
Leu Glu Tyr Asp Phe Pro Glu Lys Phe Phe Pro Lys Ala Arg Asp Leu
    210                 215                 220
Val Glu Lys Leu Leu Val Leu Asp Ala Thr Lys Arg Leu Gly Cys Glu
225                 230                 235                 240
Glu Met Glu Gly Tyr Gly Pro Leu Lys Ala His Pro Phe Phe Glu Ser
                245                 250                 255
Val Thr Trp Glu Asn Leu His Gln Gln Thr Pro Pro Lys Leu Thr Ala
            260                 265                 270
Tyr Leu Pro Ala Met Ser Glu Asp Asp Glu Asp Cys Tyr Gly Asn Tyr
        275                 280                 285
Asp Asn Leu Leu Ser Gln Phe Gly Cys Met Gln Val Ser Ser Ser Ser
    290                 295                 300
Ser Ser His Ser Leu Ser Ala Ser Asp Thr Gly Leu Pro Gln Arg Ser
305                 310                 315                 320
Gly Ser Asn Ile Glu Gln Tyr Ile His Asp Leu Asp Ser Asn Ser Phe
                325                 330                 335
Glu Leu Asp Leu Gln Phe Ser Glu Asp Glu Lys Arg Leu Leu Leu Glu
            340                 345                 350
Lys Gln Ala Gly Gly Asn Pro Trp His Gln Phe Val Glu Asn Asn Leu
        355                 360                 365
Ile Leu Lys Met Gly Pro Val Asp Lys Arg Lys Gly Leu Phe Ala Arg
    370                 375                 380
Arg Arg Gln Leu Leu Leu Thr Glu Gly Pro His Leu Tyr Tyr Val Asp
385                 390                 395                 400
Pro Val Asn Lys Val Leu Lys Gly Glu Ile Pro Trp Ser Gln Glu Leu
                405                 410                 415
Arg Pro Glu Ala Lys Asn Phe Lys Thr Phe Phe Val His Thr Pro Asn
            420                 425                 430
Arg Thr Tyr Tyr Leu Met Asp Pro Ser Gly Asn Ala His Lys Trp Cys
        435                 440                 445
Arg Lys Ile Gln Glu Val Trp Arg Gln Arg Tyr Gln Ser His Pro Asp
    450                 455                 460
Ala Ala Val Gln
465

<210> 1386
<211> 319
<212> PRT
<213> Homo sapiens

<400> 1386
Arg Ala Asn Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu
 1               5                  10                  15
Leu Thr Glu Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly
            20                  25                  30
Cys Ile Ile Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly
        35                  40                  45
Asn Glu Tyr Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe
    50                  55                  60
Pro Glu Lys Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu
65                  70                  75                  80
Val Leu Asp Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr
                85                  90                  95
Gly Pro Leu Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn
            100                 105                 110
Leu His Gln Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met
        115                 120                 125
Ser Glu Asp Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser
    130                 135                 140
Gln Phe Gly Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu
145                 150                 155                 160
Ser Ala Ser Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu
                165                 170                 175
Gln Tyr Ile His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln
            180                 185                 190
Phe Ser Glu Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly
        195                 200                 205
Asn Pro Trp His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly
    210                 215                 220
Pro Val Asp Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu
225                 230                 235                 240
Leu Thr Glu Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val
                245                 250                 255
Leu Lys Gly Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys
            260                 265                 270
Asn Phe Lys Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu
        275                 280                 285
Met Asp Pro Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu
    290                 295                 300
Val Trp Arg Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
305                 310                 315

<210> 1387
<211> 79
<212> PRT
<213> Homo sapiens

<400> 1387
Met Ser His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Asp Asp Glu Glu
 1               5                  10                  15
Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val
            20                  25                  30
Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val
        35                  40                  45
Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro
    50                  55                  60
His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
65                  70                  75

<210> 1388
<211> 63
<212> PRT
<213> Homo sapiens

<400> 1388
Met Arg Thr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val
 1               5                  10                  15
Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val
            20                  25                  30
Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro
        35                  40                  45
His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
    50                  55                  60

<210> 1389
<211> 79
<212> PRT
<213> Homo sapiens

<400> 1389
Met Ser His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Asp Asp Glu Glu
 1               5                  10                  15
Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val
            20                  25                  30
Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val
        35                  40                  45
Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro
    50                  55                  60
His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
65                  70                  75

<210> 1390
<211> 79
<212> PRT
<213> Homo sapiens

<400> 1390
Met Ser His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Asp Asp Glu Glu
 1               5                  10                  15
Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val
            20                  25                  30
Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val
        35                  40                  45
Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro
    50                  55                  60
His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
65                  70                  75

<210> 1391
<211> 79
<212> PRT
<213> Homo sapiens

<400> 1391
Met Ser His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Asp Asp Glu Glu
 1               5                  10                  15
Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val
            20                  25                  30
Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val
        35                  40                  45
Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro
    50                  55                  60
His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
65                  70                  75

<210> 1392
<211> 79
<212> PRT
<213> Homo sapiens

<400> 1392
Met Ser His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Asp Asp Lys Glu
 1               5                  10                  15
Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val
            20                  25                  30
Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val
        35                  40                  45
Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro
    50                  55                  60
His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
65                  70                  75

<210> 1393
<211> 79
<212> PRT
<213> Homo sapiens

<400> 1393
Met Ser His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Asp Asp Glu Glu
 1               5                  10                  15
Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val
            20                  25                  30
Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val
        35                  40                  45
Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro
    50                  55                  60
His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
65                  70                  75

<210> 1394
<211> 67
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(67)
<223> Xaa = Any Amino Acid

<400> 1394
Asn Trp Arg Met Arg Met Xaa His Val Met Leu Pro Lys Asp Ile Ala
 1               5                  10                  15
Lys Leu Val Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn
            20                  25                  30
Leu Gly Val Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu
        35                  40                  45
Pro Glu Pro Xaa Xaa Leu Leu Phe Arg Gly His Xaa Gln Glu Pro Arg
    50                  55                  60
Asn Xaa Val
65

<210> 1395
<211> 86
<212> PRT
<213> Homo sapiens

<400> 1395
Arg Leu Ala Asn Arg Ala Ile Met Ser His Lys Gln Ile Tyr Tyr Ser
 1               5                  10                  15
Asp Lys Tyr Asp Asp Glu Glu Phe Glu Tyr Arg His Val Met Leu Pro
            20                  25                  30
Lys Asp Ile Ala Lys Leu Val Pro Lys Thr His Leu Met Ser Glu Ser
        35                  40                  45
Glu Trp Arg Asn Leu Gly Val Gln Gln Ser Gln Gly Trp Val His Tyr
    50                  55                  60
Met Ile His Glu Pro Glu Pro His Ile Leu Leu Phe Arg Arg Pro Leu
65                  70                  75                  80
Pro Lys Lys Pro Lys Lys
                85

<210> 1396
<211> 64
<212> PRT
<213> Homo sapiens

<400> 1396
Glu Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu
 1               5                  10                  15
Val Pro Glu Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly
            20                  25                  30
Ile Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu
        35                  40                  45
Pro His Val Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
    50                  55                  60

<210> 1397
<211> 64
<212> PRT
<213> Homo sapiens

<400> 1397
Glu Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu
 1               5                  10                  15
Val Pro Glu Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly
            20                  25                  30
Ile Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu
        35                  40                  45
Pro His Val Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
    50                  55                  60

<210> 1398
<211> 64
<212> PRT
<213> Homo sapiens

<400> 1398
Glu Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu
 1               5                  10                  15
Val Pro Glu Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly
            20                  25                  30
Ile Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu
        35                  40                  45
Pro His Val Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
    50                  55                  60

<210> 1399
<211> 79
<212> PRT
<213> Homo sapiens

<400> 1399
Met Ser His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Asp Asp Glu Glu
 1               5                  10                  15
Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val
            20                  25                  30
Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val
        35                  40                  45
Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro
    50                  55                  60
His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
65                  70                  75

<210> 1400
<211> 63
<212> PRT
<213> Homo sapiens

<400> 1400
Met Arg Thr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val
 1               5                  10                  15
Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val
            20                  25                  30
Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro
        35                  40                  45
His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys
    50                  55                  60

<210> 1401
<211> 712
<212> PRT
<213> Homo sapiens

<400> 1401
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val
705                 710

<210> 1402
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1402
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr
705                 710                 715                 720
Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg
                725                 730                 735
Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val
            740                 745                 750

<210> 1403
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1403
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr
705                 710                 715                 720
Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg
                725                 730                 735
Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val
            740                 745                 750

<210> 1404
<211> 181
<212> PRT
<213> Homo sapiens

<400> 1404
Leu Asp Lys Gln Lys Glu Leu Asp Ser Lys Val Arg Asn Val Lys Asp
 1               5                  10                  15
Lys Val Met Cys Ile Glu His Glu Ile Lys Ser Leu Glu Asp Leu Gln
            20                  25                  30
Asp Glu Tyr Asp Phe Lys Cys Lys Thr Leu Gln Asn Arg Glu His Glu
        35                  40                  45
Thr Asn Gly Val Ala Lys Ser Asp Gln Lys Gln Glu Gln Leu Leu Leu
    50                  55                  60
Lys Lys Met Tyr Leu Met Leu Asp Asn Lys Arg Lys Glu Val Val His
65                  70                  75                  80
Lys Ile Ile Glu Leu Leu Asn Val Thr Glu Leu Thr Gln Asn Ala Leu
                85                  90                  95
Ile Asn Asp Glu Leu Val Glu Trp Lys Arg Arg Gln Gln Ser Ala Cys
            100                 105                 110
Ile Gly Gly Pro Pro Asn Ala Cys Leu Asp Gln Leu Gln Asn Trp Phe
        115                 120                 125
Thr Ile Val Ala Glu Ser Leu Gln Gln Val Arg Gln Gln Leu Lys Lys
    130                 135                 140
Leu Glu Glu Leu Glu Gln Lys Tyr Thr Tyr Glu His Asp Pro Ile Thr
145                 150                 155                 160
Lys Asn Lys Gln Val Leu Trp Asp Arg Thr Phe Ser Leu Phe Gln Gln
                165                 170                 175
Leu Ile Gln Ser Ser
            180

<210> 1405
<211> 786
<212> PRT
<213> Homo sapiens

<400> 1405
Arg Ser His Ser Val Tyr Ile Thr Ser Thr Val Leu Ala Pro Asn Val
 1               5                  10                  15
Leu Cys Val Leu Leu Leu Trp Leu Asn Pro Gln Ala Leu Val Gly Ala
            20                  25                  30
Gln Gly Gly Arg Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser
        35                  40                  45
Lys Phe Leu Glu Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met
    50                  55                  60
Glu Ile Arg Gln Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu
65                  70                  75                  80
His Ala Ala Asn Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu
                85                  90                  95
Leu Ser Gln Leu Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn
            100                 105                 110
Phe Leu Leu Gln His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp
        115                 120                 125
Asn Phe Gln Glu Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys
    130                 135                 140
Leu Lys Glu Glu Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln
145                 150                 155                 160
Ala Gln Ser Gly Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys
                165                 170                 175
Glu Leu Asp Ser Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile
            180                 185                 190
Glu His Glu Ile Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe
        195                 200                 205
Lys Cys Lys Thr Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala
    210                 215                 220
Lys Ser Asp Gln Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu
225                 230                 235                 240
Met Leu Asp Asn Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu
                245                 250                 255
Leu Asn Val Thr Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu
            260                 265                 270
Val Glu Trp Lys Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro
        275                 280                 285
Asn Ala Cys Leu Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu
    290                 295                 300
Ser Leu Gln Gln Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu
305                 310                 315                 320
Gln Lys Tyr Thr Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val
                325                 330                 335
Leu Trp Asp Arg Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser
            340                 345                 350
Phe Val Val Glu Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro
        355                 360                 365
Leu Val Leu Lys Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu
    370                 375                 380
Val Lys Leu Gln Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe
385                 390                 395                 400
Asp Lys Asp Val Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe
                405                 410                 415
Asn Ile Leu Gly Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr
            420                 425                 430
Asn Gly Ser Leu Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln
        435                 440                 445
Lys Asn Ala Gly Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu
    450                 455                 460
Glu Leu His Ser Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu
465                 470                 475                 480
Val Ile Asp Leu Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn
                485                 490                 495
Val Ser Gln Leu Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met
            500                 505                 510
Leu Val Ala Glu Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys
        515                 520                 525
Ala Arg Trp Ala Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser
    530                 535                 540
Val Thr Lys Arg Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu
545                 550                 555                 560
Lys Leu Leu Gly Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr
                565                 570                 575
Arg Phe Cys Lys Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu
            580                 585                 590
Trp Ile Glu Ser Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu
        595                 600                 605
Trp Asn Asp Gly Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg
    610                 615                 620
Ala Leu Leu Lys Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser
625                 630                 635                 640
Glu Ser Ser Arg Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser
                645                 650                 655
Gln Asn Gly Gly Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys
            660                 665                 670
Lys Glu Leu Ser Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys
        675                 680                 685
Val Met Ala Ala Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr
    690                 695                 700
Pro Asn Ile Asp Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro
705                 710                 715                 720
Lys Glu Ala Pro Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly
                725                 730                 735
Tyr Ile Lys Thr Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg
            740                 745                 750
Leu Gln Thr Thr Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp
        755                 760                 765
Glu Val Ser Arg Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn
    770                 775                 780
Thr Val
785

<210> 1406
<211> 739
<212> PRT
<213> Homo sapiens

<400> 1406
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Gln Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu
            260                 265                 270
Glu Gln Lys Tyr Thr Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln
        275                 280                 285
Val Leu Trp Asp Arg Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser
    290                 295                 300
Ser Phe Val Val Glu Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg
305                 310                 315                 320
Pro Leu Val Leu Lys Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu
                325                 330                 335
Leu Val Lys Leu Gln Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu
            340                 345                 350
Phe Asp Lys Asp Val Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys
        355                 360                 365
Phe Asn Ile Leu Gly Thr His Thr Lys Val Met Asn Met Glu Glu Ser
    370                 375                 380
Thr Asn Gly Ser Leu Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu
385                 390                 395                 400
Gln Lys Asn Ala Gly Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr
                405                 410                 415
Glu Glu Leu His Ser Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly
            420                 425                 430
Leu Val Ile Asp Leu Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser
        435                 440                 445
Asn Val Ser Gln Leu Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn
    450                 455                 460
Met Leu Val Ala Glu Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro
465                 470                 475                 480
Cys Ala Arg Trp Ala Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser
                485                 490                 495
Ser Val Thr Lys Arg Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly
            500                 505                 510
Glu Lys Leu Leu Gly Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp
        515                 520                 525
Thr Arg Phe Cys Lys Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp
    530                 535                 540
Leu Trp Ile Glu Ser Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro
545                 550                 555                 560
Leu Trp Asn Asp Gly Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu
                565                 570                 575
Arg Ala Leu Leu Lys Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe
            580                 585                 590
Ser Glu Ser Ser Arg Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg
        595                 600                 605
Ser Gln Asn Gly Gly Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr
    610                 615                 620
Lys Lys Glu Leu Ser Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr
625                 630                 635                 640
Lys Val Met Ala Ala Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu
                645                 650                 655
Tyr Pro Asn Ile Asp Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg
            660                 665                 670
Pro Lys Glu Ala Pro Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr
        675                 680                 685
Gly Tyr Ile Lys Thr Glu Leu Ile Ser Val Ser Glu Val His Pro Ser
    690                 695                 700
Arg Leu Gln Thr Thr Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe
705                 710                 715                 720
Asp Glu Val Ser Arg Ile Val Gly Ser Val Glu Phe Asp Ser Met Met
                725                 730                 735
Asn Thr Val


<210> 1407
<211> 701
<212> PRT
<213> Homo sapiens

<400> 1407
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Arg Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Gln Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu
            260                 265                 270
Glu Gln Lys Tyr Thr Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln
        275                 280                 285
Val Leu Trp Asp Arg Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser
    290                 295                 300
Ser Phe Val Val Glu Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg
305                 310                 315                 320
Pro Leu Val Leu Lys Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu
                325                 330                 335
Leu Val Lys Leu Gln Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu
            340                 345                 350
Phe Asp Lys Asp Val Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys
        355                 360                 365
Phe Asn Ile Leu Gly Thr His Thr Lys Val Met Asn Met Glu Glu Ser
    370                 375                 380
Thr Asn Gly Ser Leu Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu
385                 390                 395                 400
Gln Lys Asn Ala Gly Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr
                405                 410                 415
Glu Glu Leu His Ser Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly
            420                 425                 430
Leu Val Ile Asp Leu Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser
        435                 440                 445
Asn Val Ser Gln Leu Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn
    450                 455                 460
Met Leu Val Ala Glu Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro
465                 470                 475                 480
Cys Ala Arg Trp Ala Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser
                485                 490                 495
Ser Val Thr Lys Arg Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly
            500                 505                 510
Glu Lys Leu Leu Gly Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp
        515                 520                 525
Thr Arg Phe Cys Lys Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp
    530                 535                 540
Leu Trp Ile Glu Ser Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro
545                 550                 555                 560
Leu Trp Asn Asp Gly Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu
                565                 570                 575
Arg Ala Leu Leu Lys Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe
            580                 585                 590
Ser Glu Ser Ser Arg Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg
        595                 600                 605
Ser Gln Asn Gly Gly Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr
    610                 615                 620
Lys Lys Glu Leu Ser Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr
625                 630                 635                 640
Lys Val Met Ala Ala Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu
                645                 650                 655
Tyr Pro Asn Ile Asp Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg
            660                 665                 670
Pro Lys Glu Ala Pro Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr
        675                 680                 685
Gly Tyr Ile Lys Thr Glu Leu Ile Ser Val Ser Glu Val
    690                 695                 700

<210> 1408
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1408
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr
705                 710                 715                 720
Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg
                725                 730                 735
Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val
            740                 745                 750

<210> 1409
<211> 712
<212> PRT
<213> Homo sapiens

<400> 1409
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val
705                 710

<210> 1410
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1410
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr
705                 710                 715                 720
Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg
                725                 730                 735
Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val
            740                 745                 750

<210> 1411
<211> 712
<212> PRT
<213> Homo sapiens

<400> 1411
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val
705                 710

<210> 1412
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1412
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr
705                 710                 715                 720
Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg
                725                 730                 735
Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val
            740                 745                 750

<210> 1413
<211> 712
<212> PRT
<213> Homo sapiens

<400> 1413
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val
705                 710

<210> 1414
<211> 582
<212> PRT
<213> Homo sapiens

<400> 1414
Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser Lys Val Arg
 1               5                  10                  15
Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile Lys Ser Leu
            20                  25                  30
Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr Leu Gln Asn
        35                  40                  45
Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln Lys Gln Glu
    50                  55                  60
Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn Lys Arg Lys
65                  70                  75                  80
Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr Glu Leu Thr
                85                  90                  95
Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys Arg Arg Gln
            100                 105                 110
Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu Asp Gln Leu
        115                 120                 125
Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln Val Arg Gln
    130                 135                 140
Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr Tyr Glu His
145                 150                 155                 160
Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg Thr Phe Ser
                165                 170                 175
Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu Arg Gln Pro
            180                 185                 190
Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys Thr Gly Val
        195                 200                 205
Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln Glu Leu Asn
    210                 215                 220
Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val Asn Glu Arg
225                 230                 235                 240
Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly Thr His Thr
                245                 250                 255
Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu Ala Ala Glu
            260                 265                 270
Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly Thr Arg Thr
        275                 280                 285
Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser Leu Ser Phe
    290                 295                 300
Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu Glu Thr Thr
305                 310                 315                 320
Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu Pro Ser Gly
                325                 330                 335
Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu Pro Arg Asn
            340                 345                 350
Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala Gln Leu Ser
        355                 360                 365
Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg Gly Leu Asn
    370                 375                 380
Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly Pro Asn Ala
385                 390                 395                 400
Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys Glu Asn Ile
                405                 410                 415
Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser Ile Leu Glu
            420                 425                 430
Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly Cys Ile Met
        435                 440                 445
Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys Asp Gln Gln
    450                 455                 460
Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg Glu Gly Ala
465                 470                 475                 480
Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly Glu Pro Asp
                485                 490                 495
Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser Ala Val Thr
            500                 505                 510
Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala Glu Asn Ile
        515                 520                 525
Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp Lys Asp His
    530                 535                 540
Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro Glu Pro Met
545                 550                 555                 560
Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr Glu Leu Ile
                565                 570                 575
Ser Val Ser Glu Val His
            580

<210> 1415
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1415
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr
705                 710                 715                 720
Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg
                725                 730                 735
Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val
            740                 745                 750

<210> 1416
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1416
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
 1               5                  10                  15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
            20                  25                  30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
        35                  40                  45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
    50                  55                  60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65                  70                  75                  80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
                85                  90                  95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
            100                 105                 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
        115                 120                 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
    130                 135                 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145                 150                 155                 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
                165                 170                 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
            180                 185                 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
        195                 200                 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
    210                 215                 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225                 230                 235                 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
                245                 250                 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
            260                 265                 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
        275                 280                 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
    290                 295                 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305                 310                 315                 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
                325                 330                 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
            340                 345                 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
        355                 360                 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
    370                 375                 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385                 390                 395                 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
                405                 410                 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
            420                 425                 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
        435                 440                 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
    450                 455                 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465                 470                 475                 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
                485                 490                 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
            500                 505                 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
        515                 520                 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
    530                 535                 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545                 550                 555                 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
                565                 570                 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
            580                 585                 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
        595                 600                 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
    610                 615                 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625                 630                 635                 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
                645                 650                 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
            660                 665                 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
        675                 680                 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
    690                 695                 700
Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr
705                 710                 715                 720
Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg
                725                 730                 735
Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val
            740                 745                 750

<210> 1417
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1417
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1418
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1418
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1419
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1419
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Val Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1420
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1420
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1421
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1421
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1422
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1422
Gly Thr Arg Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val Ala Ile
 1               5                  10                  15
Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met Tyr His
            20                  25                  30
Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys Val Val
        35                  40                  45
Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu Leu Gly
    50                  55                  60
Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile Gln Gln
65                  70                  75                  80
Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys Ile Val
                85                  90                  95
Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu Thr Leu
            100                 105                 110
Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg Asp Lys
        115                 120                 125
His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val Val Met
    130                 135                 140
Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys Ile Gly
145                 150                 155                 160
Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro Asn Ser
                165                 170                 175
Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu Ile Ile
            180                 185                 190
Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile Tyr Ile
        195                 200                 205
Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile Val His
    210                 215                 220
Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser Cys Leu
225                 230                 235                 240
Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys Ile Met
                245                 250                 255
Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg Ser Glu
            260                 265                 270
Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr Ser Val
        275                 280                 285
Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    290                 295

<210> 1423
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1423
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1424
<211> 386
<212> PRT
<213> Homo sapiens

<400> 1424
Ser Pro Gln Lys Thr Met Arg Ser His Thr Ile Thr Met Thr Thr Thr
 1               5                  10                  15
Ser Val Ser Ser Trp Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr
            20                  25                  30
Asn His Ser Asp Gln Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val
        35                  40                  45
Thr Thr Cys Pro Met Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr
    50                  55                  60
Ser Tyr Ser Val Ile Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala
65                  70                  75                  80
Leu Tyr Val Phe Leu Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile
                85                  90                  95
Tyr Leu Leu Asn Val Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu
            100                 105                 110
Pro Phe Arg Ile Met Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly
        115                 120                 125
Val Ile Leu Cys Lys Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr
    130                 135                 140
Ile Ser Ile Ile Leu Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys
145                 150                 155                 160
Ile Asn Arg Ser Ile Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser
                165                 170                 175
Ile Tyr Val Cys Cys Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu
            180                 185                 190
Thr Met Ile Ile Leu Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met
        195                 200                 205
Cys Phe His Tyr Arg Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe
    210                 215                 220
Asn Phe Ile Leu Val Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile
225                 230                 235                 240
Leu Ser Tyr Ile Lys Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg
                245                 250                 255
Arg Ser Lys Phe Pro Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn
            260                 265                 270
Ser Phe Ile Val Leu Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His
        275                 280                 285
Ala Phe Arg Phe Ile Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys
    290                 295                 300
Tyr Trp Lys Glu Ile Val His Lys Thr Asn Glu Ile Met Leu Val Leu
305                 310                 315                 320
Ser Ser Phe Asn Ser Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser
                325                 330                 335
Ser Asn Ile Arg Lys Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln
            340                 345                 350
Gly Glu Pro Ser Arg Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr
        355                 360                 365
Ser Leu His Asp Thr Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys
    370                 375                 380
Ser Thr
385

<210> 1425
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1425
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Glu Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Arg Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Met Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1426
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1426
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Phe Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1427
<211> 386
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(386)
<223> Xaa = Any Amino Acid

<400> 1427
Ser Pro Gln Lys Thr Met Arg Ser His Thr Ile Thr Met Thr Thr Thr
 1               5                  10                  15
Ser Val Ser Ser Trp Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr
            20                  25                  30
Asn His Ser Asp Gln Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val
        35                  40                  45
Thr Thr Cys Pro Met Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr
    50                  55                  60
Ser Tyr Ser Val Ile Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala
65                  70                  75                  80
Leu Tyr Val Phe Leu Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile
                85                  90                  95
Tyr Leu Leu Asn Val Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu
            100                 105                 110
Pro Phe Arg Ile Met Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly
        115                 120                 125
Val Ile Leu Cys Lys Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr
    130                 135                 140
Ile Ser Ile Ile Leu Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys
145                 150                 155                 160
Ile Asn Arg Ser Ile Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser
                165                 170                 175
Ile Tyr Val Cys Cys Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu
            180                 185                 190
Thr Met Ile Ile Leu Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met
        195                 200                 205
Cys Phe His Tyr Arg Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe
    210                 215                 220
Asn Phe Ile Leu Val Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile
225                 230                 235                 240
Leu Ser Tyr Ile Lys Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg
                245                 250                 255
Arg Ser Lys Phe Pro Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn
            260                 265                 270
Xaa Phe Ile Val Leu Ile Ile Phe Thr Ile Xaa Phe Xaa Pro Tyr His
        275                 280                 285
Ala Phe Arg Phe Ile Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys
    290                 295                 300
Tyr Trp Lys Glu Ile Val His Lys Thr Asn Glu Ile Met Leu Val Leu
305                 310                 315                 320
Ser Ser Phe Asn Ser Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser
                325                 330                 335
Ser Asn Ile Arg Lys Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln
            340                 345                 350
Gly Glu Pro Ser Arg Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr
        355                 360                 365
Ser Leu His Asp Thr Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys
    370                 375                 380
Ser Thr
385

<210> 1428
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1428
Gly Thr Arg Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val Ala Ile
 1               5                  10                  15
Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met Tyr His
            20                  25                  30
Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys Val Val
        35                  40                  45
Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu Leu Gly
    50                  55                  60
Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile Gln Gln
65                  70                  75                  80
Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys Ile Val
                85                  90                  95
Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu Thr Leu
            100                 105                 110
Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg Asp Lys
        115                 120                 125
His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val Val Met
    130                 135                 140
Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys Ile Gly
145                 150                 155                 160
Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro Asn Ser
                165                 170                 175
Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu Ile Ile
            180                 185                 190
Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile Tyr Ile
        195                 200                 205
Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile Val His
    210                 215                 220
Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser Cys Leu
225                 230                 235                 240
Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys Ile Met
                245                 250                 255
Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg Ser Glu
            260                 265                 270
Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr Ser Val
        275                 280                 285
Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    290                 295

<210> 1429
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1429
Gly Thr Arg Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val Ala Ile
 1               5                  10                  15
Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met Tyr His
            20                  25                  30
Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys Val Val
        35                  40                  45
Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu Leu Gly
    50                  55                  60
Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile Gln Gln
65                  70                  75                  80
Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys Ile Val
                85                  90                  95
Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu Thr Leu
            100                 105                 110
Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg Asp Lys
        115                 120                 125
His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val Val Met
    130                 135                 140
Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys Ile Gly
145                 150                 155                 160
Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro Asn Ser
                165                 170                 175
Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu Ile Ile
            180                 185                 190
Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile Tyr Ile
        195                 200                 205
Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile Val His
    210                 215                 220
Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser Cys Leu
225                 230                 235                 240
Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys Ile Met
                245                 250                 255
Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg Ser Glu
            260                 265                 270
Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr Ser Val
        275                 280                 285
Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    290                 295

<210> 1430
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1430
Gly Thr Arg Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val Ala Ile
 1               5                  10                  15
Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met Tyr His
            20                  25                  30
Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys Val Val
        35                  40                  45
Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu Leu Gly
    50                  55                  60
Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile Gln Gln
65                  70                  75                  80
Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys Ile Val
                85                  90                  95
Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu Thr Leu
            100                 105                 110
Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg Asp Lys
        115                 120                 125
His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val Val Met
    130                 135                 140
Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys Ile Gly
145                 150                 155                 160
Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro Asn Ser
                165                 170                 175
Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu Ile Ile
            180                 185                 190
Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile Tyr Ile
        195                 200                 205
Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile Val His
    210                 215                 220
Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser Cys Leu
225                 230                 235                 240
Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys Ile Met
                245                 250                 255
Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg Ser Glu
            260                 265                 270
Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr Ser Val
        275                 280                 285
Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    290                 295

<210> 1431
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1431
Gly Thr Arg Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val Ala Ile
 1               5                  10                  15
Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met Tyr His
            20                  25                  30
Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys Val Val
        35                  40                  45
Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu Leu Gly
    50                  55                  60
Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile Gln Gln
65                  70                  75                  80
Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys Ile Val
                85                  90                  95
Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu Thr Leu
            100                 105                 110
Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg Asp Lys
        115                 120                 125
His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val Val Met
    130                 135                 140
Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys Ile Gly
145                 150                 155                 160
Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro Asn Ser
                165                 170                 175
Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu Ile Ile
            180                 185                 190
Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile Tyr Ile
        195                 200                 205
Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile Val His
    210                 215                 220
Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser Cys Leu
225                 230                 235                 240
Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys Ile Met
                245                 250                 255
Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg Ser Glu
            260                 265                 270
Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr Ser Val
        275                 280                 285
Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    290                 295

<210> 1432
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1432
Gly Thr Arg Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val Ala Ile
 1               5                  10                  15
Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met Tyr His
            20                  25                  30
Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys Val Val
        35                  40                  45
Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu Leu Gly
    50                  55                  60
Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile Gln Gln
65                  70                  75                  80
Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys Ile Val
                85                  90                  95
Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu Thr Leu
            100                 105                 110
Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg Asp Lys
        115                 120                 125
His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val Val Met
    130                 135                 140
Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys Ile Gly
145                 150                 155                 160
Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro Asn Ser
                165                 170                 175
Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu Ile Ile
            180                 185                 190
Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile Tyr Ile
        195                 200                 205
Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile Val His
    210                 215                 220
Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser Cys Leu
225                 230                 235                 240
Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys Ile Met
                245                 250                 255
Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg Ser Glu
            260                 265                 270
Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr Ser Val
        275                 280                 285
Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    290                 295

<210> 1433
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1433
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Pro Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Leu Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Val Gly Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Trp Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Gly Lys Ile Gln Ser Ser Ser Glu Ser Thr
    370                 375                 380

<210> 1434
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1434
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1435
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1435
Gly Thr Arg Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val Ala Ile
 1               5                  10                  15
Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met Tyr His
            20                  25                  30
Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys Val Val
        35                  40                  45
Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu Leu Gly
    50                  55                  60
Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile Gln Gln
65                  70                  75                  80
Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys Ile Val
                85                  90                  95
Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu Thr Leu
            100                 105                 110
Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg Asp Lys
        115                 120                 125
His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val Val Met
    130                 135                 140
Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys Ile Gly
145                 150                 155                 160
Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro Asn Ser
                165                 170                 175
Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu Ile Ile
            180                 185                 190
Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile Tyr Ile
        195                 200                 205
Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile Val His
    210                 215                 220
Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser Cys Leu
225                 230                 235                 240
Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys Ile Met
                245                 250                 255
Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg Ser Glu
            260                 265                 270
Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr Ser Val
        275                 280                 285
Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    290                 295

<210> 1436
<211> 386
<212> PRT
<213> Homo sapiens

<400> 1436
Ser Pro Gln Lys Thr Met Arg Ser His Thr Ile Thr Met Thr Thr Thr
 1               5                  10                  15
Ser Val Ser Ser Trp Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr
            20                  25                  30
Asn His Ser Asp Gln Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val
        35                  40                  45
Thr Thr Cys Pro Met Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr
    50                  55                  60
Ser Tyr Ser Val Ile Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala
65                  70                  75                  80
Leu Tyr Val Phe Leu Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile
                85                  90                  95
Tyr Leu Leu Asn Val Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu
            100                 105                 110
Pro Phe Arg Ile Met Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly
        115                 120                 125
Val Ile Leu Cys Lys Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr
    130                 135                 140
Ile Ser Ile Ile Leu Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys
145                 150                 155                 160
Ile Asn Arg Ser Ile Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser
                165                 170                 175
Ile Tyr Val Cys Cys Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu
            180                 185                 190
Thr Met Ile Ile Leu Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met
        195                 200                 205
Cys Phe His Tyr Arg Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe
    210                 215                 220
Asn Phe Ile Leu Val Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile
225                 230                 235                 240
Leu Ser Tyr Ile Lys Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg
                245                 250                 255
Arg Ser Lys Phe Pro Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn
            260                 265                 270
Ser Phe Ile Val Leu Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His
        275                 280                 285
Ala Phe Arg Phe Ile Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys
    290                 295                 300
Tyr Trp Lys Glu Ile Val His Lys Thr Asn Glu Ile Met Leu Val Leu
305                 310                 315                 320
Ser Ser Phe Asn Ser Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser
                325                 330                 335
Ser Asn Ile Arg Lys Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln
            340                 345                 350
Gly Glu Pro Ser Arg Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr
        355                 360                 365
Ser Leu His Asp Thr Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys
    370                 375                 380
Ser Thr
385

<210> 1437
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1437
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1438
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1438
Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp
 1               5                  10                  15
Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln
            20                  25                  30
Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met
        35                  40                  45
Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile
    50                  55                  60
Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu
65                  70                  75                  80
Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val
                85                  90                  95
Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met
            100                 105                 110
Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys
        115                 120                 125
Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu
    130                 135                 140
Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile
145                 150                 155                 160
Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys
                165                 170                 175
Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu
            180                 185                 190
Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg
        195                 200                 205
Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val
    210                 215                 220
Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys
225                 230                 235                 240
Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro
                245                 250                 255
Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu
            260                 265                 270
Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile
        275                 280                 285
Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile
    290                 295                 300
Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser
305                 310                 315                 320
Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys
                325                 330                 335
Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg
            340                 345                 350
Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr
        355                 360                 365
Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr
    370                 375                 380

<210> 1439
<211> 839
<212> PRT
<213> Homo sapiens

<400> 1439
Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala
 1               5                  10                  15
Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val
            20                  25                  30
Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile
        35                  40                  45
Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn
    50                  55                  60
Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu
65                  70                  75                  80
Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly
                85                  90                  95
Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn
            100                 105                 110
Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu
        115                 120                 125
Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe
    130                 135                 140
Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn
145                 150                 155                 160
Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn
                165                 170                 175
Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys
            180                 185                 190
Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu
        195                 200                 205
Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys
    210                 215                 220
Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu
225                 230                 235                 240
Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His
                245                 250                 255
Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe
            260                 265                 270
Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe
        275                 280                 285
Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe
    290                 295                 300
Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile
305                 310                 315                 320
Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu
                325                 330                 335
Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser
            340                 345                 350
Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser
        355                 360                 365
Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly
    370                 375                 380
Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser
385                 390                 395                 400
Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser
                405                 410                 415
Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser
            420                 425                 430
Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn
        435                 440                 445
Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn
    450                 455                 460
Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly
465                 470                 475                 480
Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg
                485                 490                 495
Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser
            500                 505                 510
Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser
        515                 520                 525
His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn
    530                 535                 540
Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys
545                 550                 555                 560
Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu
                565                 570                 575
Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln
            580                 585                 590
Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu
        595                 600                 605
Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn
    610                 615                 620
Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser
625                 630                 635                 640
Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe
                645                 650                 655
His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn
            660                 665                 670
Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val
        675                 680                 685
Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln
    690                 695                 700
Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala
705                 710                 715                 720
Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val
                725                 730                 735
Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu
            740                 745                 750
Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe
        755                 760                 765
Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu
    770                 775                 780
Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser
785                 790                 795                 800
Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu
                805                 810                 815
Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn
            820                 825                 830
Trp Gln Glu Ala Thr Ser Ile
        835

<210> 1440
<211> 839
<212> PRT
<213> Homo sapiens

<400> 1440
Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala
 1               5                  10                  15
Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val
            20                  25                  30
Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile
        35                  40                  45
Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn
    50                  55                  60
Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu
65                  70                  75                  80
Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly
                85                  90                  95
Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn
            100                 105                 110
Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu
        115                 120                 125
Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe
    130                 135                 140
Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn
145                 150                 155                 160
Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn
                165                 170                 175
Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys
            180                 185                 190
Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu
        195                 200                 205
Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys
    210                 215                 220
Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu
225                 230                 235                 240
Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His
                245                 250                 255
Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe
            260                 265                 270
Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe
        275                 280                 285
Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe
    290                 295                 300
Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile
305                 310                 315                 320
Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu
                325                 330                 335
Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser
            340                 345                 350
Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser
        355                 360                 365
Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly
    370                 375                 380
Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser
385                 390                 395                 400
Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser
                405                 410                 415
Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser
            420                 425                 430
Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn
        435                 440                 445
Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn
    450                 455                 460
Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly
465                 470                 475                 480
Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg
                485                 490                 495
Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser
            500                 505                 510
Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser
        515                 520                 525
His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn
    530                 535                 540
Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys
545                 550                 555                 560
Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu
                565                 570                 575
Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln
            580                 585                 590
Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu
        595                 600                 605
Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn
    610                 615                 620
Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser
625                 630                 635                 640
Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe
                645                 650                 655
His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn
            660                 665                 670
Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val
        675                 680                 685
Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln
    690                 695                 700
Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala
705                 710                 715                 720
Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val
                725                 730                 735
Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu
            740                 745                 750
Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe
        755                 760                 765
Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu
    770                 775                 780
Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser
785                 790                 795                 800
Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu
                805                 810                 815
Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn
            820                 825                 830
Trp Gln Glu Ala Thr Ser Ile
        835

<210> 1441
<211> 839
<212> PRT
<213> Homo sapiens

<400> 1441
Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala
 1               5                  10                  15
Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val
            20                  25                  30
Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile
        35                  40                  45
Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn
    50                  55                  60
Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu
65                  70                  75                  80
Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly
                85                  90                  95
Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn
            100                 105                 110
Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu
        115                 120                 125
Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe
    130                 135                 140
Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn
145                 150                 155                 160
Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn
                165                 170                 175
Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys
            180                 185                 190
Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu
        195                 200                 205
Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys
    210                 215                 220
Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu
225                 230                 235                 240
Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His
                245                 250                 255
Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe
            260                 265                 270
Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe
        275                 280                 285
Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe
    290                 295                 300
Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile
305                 310                 315                 320
Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu
                325                 330                 335
Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser
            340                 345                 350
Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser
        355                 360                 365
Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly
    370                 375                 380
Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser
385                 390                 395                 400
Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser
                405                 410                 415
Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser
            420                 425                 430
Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn
        435                 440                 445
Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn
    450                 455                 460
Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly
465                 470                 475                 480
Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg
                485                 490                 495
Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser
            500                 505                 510
Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser
        515                 520                 525
His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn
    530                 535                 540
Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys
545                 550                 555                 560
Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu
                565                 570                 575
Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln
            580                 585                 590
Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu
        595                 600                 605
Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn
    610                 615                 620
Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser
625                 630                 635                 640
Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe
                645                 650                 655
His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn
            660                 665                 670
Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val
        675                 680                 685
Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln
    690                 695                 700
Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala
705                 710                 715                 720
Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val
                725                 730                 735
Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu
            740                 745                 750
Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe
        755                 760                 765
Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu
    770                 775                 780
Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser
785                 790                 795                 800
Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu
                805                 810                 815
Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn
            820                 825                 830
Trp Gln Glu Ala Thr Ser Ile
        835

<210> 1442
<211> 837
<212> PRT
<213> Homo sapiens

<400> 1442
Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala Phe
 1               5                  10                  15
Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val Pro
            20                  25                  30
Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile Pro Asp
        35                  40                  45
Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn Pro Leu
    50                  55                  60
Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu Gln Val
65                  70                  75                  80
Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr
                85                  90                  95
Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile
            100                 105                 110
Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys
        115                 120                 125
Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile
    130                 135                 140
Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn Leu Ile
145                 150                 155                 160
Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn Leu Glu
                165                 170                 175
His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys Thr Asp
            180                 185                 190
Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu Asp Leu
        195                 200                 205
Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile
    210                 215                 220
Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu Asn Val
225                 230                 235                 240
Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His Arg Leu
                245                 250                 255
Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys
            260                 265                 270
Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu
        275                 280                 285
Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe Asn Cys
    290                 295                 300
Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile Glu Arg
305                 310                 315                 320
Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu Leu Val
                325                 330                 335
Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys
            340                 345                 350
Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser Glu Val
        355                 360                 365
Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser
    370                 375                 380
Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys
385                 390                 395                 400
Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser Asn Phe
                405                 410                 415
Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser Asn Leu
            420                 425                 430
Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn Leu Ile
        435                 440                 445
Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn Gly Ile
    450                 455                 460
Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly Asn Ser
465                 470                 475                 480
Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg Asn Leu
                485                 490                 495
Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr
            500                 505                 510
Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser His Asn
        515                 520                 525
Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu
    530                 535                 540
Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys Lys Gln
545                 550                 555                 560
Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu Thr Gln
                565                 570                 575
Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln Trp Ile
            580                 585                 590
Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu Cys Ala
        595                 600                 605
Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn Ile Thr
    610                 615                 620
Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu
625                 630                 635                 640
Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu
                645                 650                 655
Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr
            660                 665                 670
Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn
        675                 680                 685
Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys
    690                 695                 700
Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile
705                 710                 715                 720
Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val Ser
                725                 730                 735
Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala
            740                 745                 750
Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val
        755                 760                 765
Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr
    770                 775                 780
Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu
785                 790                 795                 800
Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly
                805                 810                 815
Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn Trp Gln
            820                 825                 830
Glu Ala Thr Ser Ile
        835

<210> 1443
<211> 43
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(43)
<223> Xaa = Any Amino Acid

<400> 1443
Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala
 1               5                  10                  15
Phe Leu Ser Cys Val Arg Pro Glu Ser Xaa Glu Pro Cys Val Glu Val
            20                  25                  30
Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu
        35                  40

<210> 1444
<211> 78
<212> PRT
<213> Homo sapiens

<400> 1444
Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu Lys Phe Leu Ala
 1               5                  10                  15
Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe Gln Met Glu Gln
            20                  25                  30
Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile Ile Asn Leu Lys
        35                  40                  45
Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala Ile Val Ala Ile
    50                  55                  60
Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg Asn Thr
65                  70                  75

<210> 1445
<211> 78
<212> PRT
<213> Homo sapiens

<400> 1445
Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu Lys Phe Leu Ala
 1               5                  10                  15
Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe Gln Met Glu Gln
            20                  25                  30
Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile Ile Asn Leu Lys
        35                  40                  45
Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala Ile Val Ala Ile
    50                  55                  60
Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg Asn Thr
65                  70                  75

<210> 1446
<211> 78
<212> PRT
<213> Homo sapiens

<400> 1446
Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu Lys Phe Leu Ala
 1               5                  10                  15
Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe Gln Met Glu Gln
            20                  25                  30
Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile Ile Asn Leu Lys
        35                  40                  45
Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala Ile Val Ala Ile
    50                  55                  60
Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg Asn Thr
65                  70                  75

<210> 1447
<211> 78
<212> PRT
<213> Homo sapiens

<400> 1447
Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu Lys Phe Leu Ala
 1               5                  10                  15
Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe Gln Met Glu Gln
            20                  25                  30
Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile Ile Asn Leu Lys
        35                  40                  45
Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala Ile Val Ala Ile
    50                  55                  60
Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg Asn Thr
65                  70                  75

<210> 1448
<211> 264
<212> PRT
<213> Homo sapiens

<400> 1448
Met Ala Asp Thr Phe Ser Leu Asn Asp Ala Leu Ala Gly Ser Gly Asn
 1               5                  10                  15
Pro Asn Pro Gln Gly Tyr Pro Gly Ala Trp Gly Asn Gln Pro Gly Ala
            20                  25                  30
Gly Gly Tyr Pro Gly Ala Ala Tyr Pro Gly Ala Tyr Pro Gly Gln Ala
        35                  40                  45
Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly
    50                  55                  60
Gln Ala Pro Pro Ser Ala Tyr Pro Gly Pro Thr Ala Pro Gly Ala Tyr
65                  70                  75                  80
Pro Gly Pro Thr Ala Pro Gly Ala Tyr Pro Gly Ser Thr Ala Pro Gly
                85                  90                  95
Ala Phe Pro Gly Gln Pro Gly Ala Pro Gly Ala Tyr Pro Ser Ala Pro
            100                 105                 110
Gly Gly Tyr Pro Ala Ala Gly Pro Tyr Gly Val Pro Ala Gly Pro Leu
        115                 120                 125
Thr Val Pro Tyr Asp Leu Pro Leu Pro Gly Gly Leu Met Pro Arg Met
    130                 135                 140
Leu Ile Thr Ile Met Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Val
145                 150                 155                 160
Leu Asp Phe Arg Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg
                165                 170                 175
Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Gln Asp
            180                 185                 190
Asn Asn Trp Gly Lys Glu Glu Arg Gln Ser Ala Phe Pro Phe Glu Ser
        195                 200                 205
Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Ala Asp His Phe Lys
    210                 215                 220
Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Met Lys
225                 230                 235                 240
Asn Leu Arg Glu Ile Ser Gln Leu Gly Ile Ser Gly Asp Ile Thr Leu
                245                 250                 255
Thr Ser Ala Asn His Ala Met Ile
            260

<210> 1449
<211> 591
<212> PRT
<213> Homo sapiens

<400> 1449
Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu Leu Pro Ala Arg
 1               5                  10                  15
Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro Thr Ser Ser Glu
            20                  25                  30
Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro Pro Lys Ala Ala
        35                  40                  45
Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys Ser Pro Leu Gly
    50                  55                  60
Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala Arg Pro Ala Ala
65                  70                  75                  80
Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro Leu Ser Leu Ala
                85                  90                  95
Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His Val His Met Ser
            100                 105                 110
Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Leu Thr Phe
        115                 120                 125
Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala Asp Val Thr Gln
    130                 135                 140
Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln Thr Gly Leu Gln
145                 150                 155                 160
Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala Ala Ala Val Leu
                165                 170                 175
Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser Val Leu Leu Thr
            180                 185                 190
Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val Ala Leu Ala Val
        195                 200                 205
Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu
    210                 215                 220
Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr
225                 230                 235                 240
Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser Leu Phe Asn Arg
                245                 250                 255
Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln
            260                 265                 270
Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro
        275                 280                 285
Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp Ile Ser Thr Gly
    290                 295                 300
His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg Asn Arg Asp Arg
305                 310                 315                 320
Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn
                325                 330                 335
Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys Lys Asn Arg His
            340                 345                 350
Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys Leu Lys Val Glu
        355                 360                 365
Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser Pro Ile Ile Glu
    370                 375                 380
His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser
385                 390                 395                 400
His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr
                405                 410                 415
Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys
            420                 425                 430
Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr His Val Tyr Glu
        435                 440                 445
Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg
    450                 455                 460
Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr
465                 470                 475                 480
Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr Pro Ala Ser Thr
                485                 490                 495
Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly
            500                 505                 510
Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala Gly Arg Thr
        515                 520                 525
Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly
    530                 535                 540
Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His Val Arg Asp Gln
545                 550                 555                 560
Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu Phe Ala Leu Thr
                565                 570                 575
Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala Leu Pro Gln
            580                 585                 590

<210> 1450
<211> 979
<212> PRT
<213> Homo sapiens

<400> 1450
Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu
 1               5                  10                  15
Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys
            20                  25                  30
Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser
        35                  40                  45
His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val
    50                  55                  60
Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu
65                  70                  75                  80
Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser
                85                  90                  95
Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg
            100                 105                 110
Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly
        115                 120                 125
Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp
    130                 135                 140
Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro
145                 150                 155                 160
Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu
                165                 170                 175
Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro
            180                 185                 190
Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro
        195                 200                 205
Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu
    210                 215                 220
Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala
225                 230                 235                 240
Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His
                245                 250                 255
Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu
            260                 265                 270
Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro
        275                 280                 285
Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg
    290                 295                 300
Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg
305                 310                 315                 320
Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln
                325                 330                 335
Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu
            340                 345                 350
Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro
        355                 360                 365
Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp
    370                 375                 380
Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu
385                 390                 395                 400
Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro
                405                 410                 415
Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro
            420                 425                 430
Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys
        435                 440                 445
Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala
    450                 455                 460
Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro
465                 470                 475                 480
Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His
                485                 490                 495
Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro
            500                 505                 510
Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala
        515                 520                 525
Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln
    530                 535                 540
Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala
545                 550                 555                 560
Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser
                565                 570                 575
Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val
            580                 585                 590
Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp
        595                 600                 605
Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr
    610                 615                 620
Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser
625                 630                 635                 640
Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser
                645                 650                 655
Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His
            660                 665                 670
Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp
        675                 680                 685
Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg
    690                 695                 700
Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln
705                 710                 715                 720
Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys
                725                 730                 735
Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys
            740                 745                 750
Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser
        755                 760                 765
Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln
    770                 775                 780
Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu
785                 790                 795                 800
Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly
                805                 810                 815
Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr
            820                 825                 830
His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp
        835                 840                 845
Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr
    850                 855                 860
Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr
865                 870                 875                 880
Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys
                885                 890                 895
Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly
            900                 905                 910
Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg
        915                 920                 925
Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His
    930                 935                 940
Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu
945                 950                 955                 960
Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala
                965                 970                 975
Leu Pro Gln


<210> 1451
<211> 591
<212> PRT
<213> Homo sapiens

<400> 1451
Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu Leu Pro Ala Arg
 1               5                  10                  15
Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro Thr Ser Ser Glu
            20                  25                  30
Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro Pro Lys Ala Ala
        35                  40                  45
Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys Ser Pro Leu Gly
    50                  55                  60
Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala Arg Pro Ala Ala
65                  70                  75                  80
Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro Leu Ser Leu Ala
                85                  90                  95
Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His Val His Met Ser
            100                 105                 110
Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Leu Thr Phe
        115                 120                 125
Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala Asp Val Thr Gln
    130                 135                 140
Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln Thr Gly Leu Gln
145                 150                 155                 160
Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala Ala Ala Val Leu
                165                 170                 175
Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser Val Leu Leu Thr
            180                 185                 190
Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val Ala Leu Ala Val
        195                 200                 205
Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu
    210                 215                 220
Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr
225                 230                 235                 240
Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser Leu Phe Asn Arg
                245                 250                 255
Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln
            260                 265                 270
Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro
        275                 280                 285
Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp Ile Ser Thr Gly
    290                 295                 300
His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg Asn Arg Asp Arg
305                 310                 315                 320
Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn
                325                 330                 335
Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys Lys Asn Arg His
            340                 345                 350
Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys Leu Lys Val Glu
        355                 360                 365
Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser Pro Ile Ile Glu
    370                 375                 380
His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser
385                 390                 395                 400
His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr
                405                 410                 415
Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys
            420                 425                 430
Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr His Val Tyr Glu
        435                 440                 445
Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg
    450                 455                 460
Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr
465                 470                 475                 480
Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr Pro Ala Ser Thr
                485                 490                 495
Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly
            500                 505                 510
Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala Gly Arg Thr
        515                 520                 525
Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly
    530                 535                 540
Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His Val Arg Asp Gln
545                 550                 555                 560
Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu Phe Ala Leu Thr
                565                 570                 575
Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala Leu Pro Gln
            580                 585                 590

<210> 1452
<211> 916
<212> PRT
<213> Homo sapiens

<400> 1452
Trp Arg Cys Ser Pro Arg Gly Gly Arg Ser Ala Thr Ala Gly Arg Pro
 1               5                  10                  15
Ala Ala Gly Gly Pro Arg Ser Pro Arg Ser Pro Arg Ser Pro Arg Ala
            20                  25                  30
Ala Ala Gly Leu Ile Leu Pro Gly Ser Glu Leu Ser Pro Gly Arg Trp
        35                  40                  45
Asn Ala Ser Pro Arg Leu Arg Pro Pro Glu Pro His Pro Arg Asp Arg
    50                  55                  60
Ser Gly Leu Val Pro Arg Lys Pro Gly Pro Ala Gly Glu Leu Leu Thr
65                  70                  75                  80
Gln Gly Asn Pro Thr Gly Ser Ser Pro Ala Ala Gln Gly Phe Pro Arg
                85                  90                  95
Pro Ala Gly Gly Gly Asp Gly Ala Gly Ala Gly Ser Pro Leu Ser Ser
            100                 105                 110
Leu Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Met Pro
        115                 120                 125
Pro Gln Pro Pro His Pro Ala Leu Thr Tyr Glu Pro Ala Leu Leu Gln
    130                 135                 140
Pro Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Gly Ser
145                 150                 155                 160
Glu Ser Ser Ser Gly Val Val Gly Val Gly His Leu Ser Lys Ala Glu
                165                 170                 175
Gly Pro Ala Leu Phe Ser Arg Ser Ala Ser Lys Ala Ile Leu Gly Thr
            180                 185                 190
His Ser Gly His Ser Phe Gly Asp Leu Thr Gly Pro Ser Pro Ala Gln
        195                 200                 205
Leu Phe Gln Asp Ser Gly Leu Leu Tyr Met Ala Gln Glu Leu Pro Val
    210                 215                 220
Pro Gly Arg Ala Arg Ala Pro Arg Leu Pro Glu Asn Gly Gly Asn Arg
225                 230                 235                 240
Ala Glu Asp Ser Ser Glu Gly His Glu Glu Glu Val Leu Gly Gly Arg
                245                 250                 255
Gly Glu Lys Ser Pro Pro Gln Ala Ala Gln Pro Glu Leu Ser Leu Gln
            260                 265                 270
Arg Leu Thr Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu
        275                 280                 285
Thr Pro Glu Gln Phe Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro
    290                 295                 300
Lys Gly Thr Gly Arg Asn Leu Glu Gly Ala Val Asn Val Gly Gly Ala
305                 310                 315                 320
Asp Val Lys Lys Thr Ile Gln Gln Met Gln Arg Gly Asp Pro Ala Glu
                325                 330                 335
Ala Leu Pro Pro Thr Pro Ser Leu Pro Gly Tyr Leu Thr Ala Ser Pro
            340                 345                 350
Ala Ser Ser Glu Val Gln Gln Val Leu Ser Pro Gly Phe Pro Glu Pro
        355                 360                 365
Pro His Thr Pro Ser Pro Leu Gly Ser Ser Ser Val Leu Leu Glu Lys
    370                 375                 380
Lys Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Val Gly Arg Pro Ser
385                 390                 395                 400
Ala Arg Pro Ser Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys
                405                 410                 415
Pro Leu Ser Leu Val Ala Gly Val Arg Leu Leu Glu Ile Leu Ala Glu
            420                 425                 430
His Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly
        435                 440                 445
Pro Ala Val Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu
    450                 455                 460
Ala Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala
465                 470                 475                 480
Gln Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu
                485                 490                 495
Ala Ala Glu Val Leu Pro Arg Gln Ala His Gly Ile Ser Pro Met Arg
            500                 505                 510
Ser Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu
        515                 520                 525
Val Ala Leu Ala Val Ala Leu Cys Met Arg His His Ser Arg Gln Arg
    530                 535                 540
Asp Lys Glu Arg Leu Ala Ala Val Gly Pro Glu Gly Ala His Gly Asp
545                 550                 555                 560
Thr Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys
                565                 570                 575
Ser Leu Phe Asn Arg Ala Glu Gly Gln Pro Glu Pro Ser Arg Val Ser
            580                 585                 590
Ser Val Ser Ser Gln Phe Ser Asp Ala Pro Gln Ala Ser Pro Ser Ser
        595                 600                 605
His Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met
    610                 615                 620
Asp Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu
625                 630                 635                 640
Arg Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr
                645                 650                 655
Gln Ala Glu Pro Asn Thr Cys Ala Ala Ala Gln Asp Glu Ser Asn Ile
            660                 665                 670
Lys Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile
        675                 680                 685
Lys Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala
    690                 695                 700
Ser Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr
705                 710                 715                 720
Gln Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp
                725                 730                 735
Glu Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp
            740                 745                 750
Gly Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ser Ser Leu
        755                 760                 765
Tyr Gln Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu
    770                 775                 780
Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu
785                 790                 795                 800
Thr Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly
                805                 810                 815
Thr Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn
            820                 825                 830
Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp
        835                 840                 845
Gly Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn
    850                 855                 860
Arg Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu
865                 870                 875                 880
His Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe
                885                 890                 895
Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys
            900                 905                 910
Ala Leu Pro Gln
        915

<210> 1453
<211> 961
<212> PRT
<213> Homo sapiens

<400> 1453
Leu Leu Val Cys Leu Leu Leu Leu Ser Gly Arg Pro Gly Gly Cys Ser
 1               5                  10                  15
Ala Ile Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser His
            20                  25                  30
Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Ala Gly
        35                  40                  45
Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu Gln
    50                  55                  60
Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser Trp
65                  70                  75                  80
His Asp Asp Leu Thr Gln His Val Ile Ser Gln Glu Met Glu Arg Ile
                85                  90                  95
Pro Arg Leu Arg Pro Pro Glu Pro His Pro Arg Asp Arg Ser Gly Leu
            100                 105                 110
Val Pro Arg Lys Pro Gly Pro Ala Gly Glu Leu Leu Thr Gln Gly Asn
        115                 120                 125
Pro Thr Gly Ser Ser Pro Ala Ala Gln Gly Phe Pro Arg Pro Ala Gly
    130                 135                 140
Gly Gly Asp Gly Ala Gly Ala Gly Ser Pro Leu Ser Ser Leu Gln Ala
145                 150                 155                 160
Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Met Pro Pro Gln Pro
                165                 170                 175
Pro His Pro Ala Leu Thr Tyr Glu Pro Ala Leu Leu Gln Pro Tyr Leu
            180                 185                 190
Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Gly Ser Glu Ser Ser
        195                 200                 205
Ser Gly Val Val Gly Val Gly His Leu Ser Lys Ala Glu Gly Pro Ala
    210                 215                 220
Leu Phe Ser Arg Ser Ala Ser Lys Ala Ile Leu Gly Thr His Ser Gly
225                 230                 235                 240
His Ser Phe Gly Asp Leu Thr Gly Pro Ser Pro Ala Gln Leu Phe Gln
                245                 250                 255
Asp Ser Gly Leu Leu Tyr Met Ala Gln Glu Leu Pro Val Pro Gly Arg
            260                 265                 270
Ala Arg Ala Pro Arg Leu Pro Glu Asn Gly Gly Asn Arg Ala Glu Asp
        275                 280                 285
Ser Ser Glu Gly His Glu Glu Glu Val Leu Gly Gly Arg Gly Glu Lys
    290                 295                 300
Ser Pro Pro Gln Ala Ala Gln Pro Glu Leu Ser Leu Gln Arg Leu Thr
305                 310                 315                 320
Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu Thr Pro Glu
                325                 330                 335
Gln Phe Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro Lys Gly Thr
            340                 345                 350
Gly Arg Asn Leu Glu Gly Ala Val Asn Val Gly Gly Ala Asp Val Lys
        355                 360                 365
Lys Thr Ile Gln Gln Met Gln Arg Gly Asp Pro Ala Glu Ala Leu Pro
    370                 375                 380
Pro Thr Pro Ser Leu Pro Gly Tyr Leu Thr Ala Ser Pro Ala Ser Ser
385                 390                 395                 400
Glu Val Gln Gln Val Leu Ser Pro Gly Phe Pro Glu Pro Pro His Thr
                405                 410                 415
Pro Ser Pro Leu Gly Ser Ser Ser Val Leu Leu Glu Lys Lys Ser Pro
            420                 425                 430
Leu Gly Gln Ser Gln Pro Thr Val Val Gly Arg Pro Ser Ala Arg Pro
        435                 440                 445
Ser Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro Leu Ser
    450                 455                 460
Leu Val Ala Gly Val Arg Leu Leu Glu Ile Leu Ala Glu His Val His
465                 470                 475                 480
Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Val
                485                 490                 495
Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala Asp Val
            500                 505                 510
Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln Thr Gly
        515                 520                 525
Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala Ala Glu
    530                 535                 540
Val Leu Pro Arg Gln Ala His Gly Ile Ser Pro Met Arg Ser Val Leu
545                 550                 555                 560
Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val Ala Leu
                565                 570                 575
Ala Val Ala Leu Cys Met Arg His His Ser Arg Gln Arg Asp Lys Glu
            580                 585                 590
Arg Leu Ala Ala Val Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe
        595                 600                 605
Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser Leu Phe
    610                 615                 620
Asn Arg Ala Glu Gly Gln Pro Glu Pro Ser Arg Val Ser Ser Val Ser
625                 630                 635                 640
Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser
                645                 650                 655
Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp Ile Ser
            660                 665                 670
Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg Asn Arg
        675                 680                 685
Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu
    690                 695                 700
Pro Asn Thr Cys Ala Ala Ala Gln Asp Glu Ser Asn Ile Lys Lys Asn
705                 710                 715                 720
Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys Leu Lys
                725                 730                 735
Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser Pro Ile
            740                 745                 750
Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln Gly Pro
        755                 760                 765
Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly
    770                 775                 780
Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys
785                 790                 795                 800
Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ser Ser Leu Tyr His Val
                805                 810                 815
Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe Leu
            820                 825                 830
Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr
        835                 840                 845
Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr Pro Ala
    850                 855                 860
Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr
865                 870                 875                 880
Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala Gly
                885                 890                 895
Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala
            900                 905                 910
Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His Val Arg
        915                 920                 925
Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu Phe Ala
    930                 935                 940
Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala Leu Pro
945                 950                 955                 960
Gln


<210> 1454
<211> 548
<212> PRT
<213> Homo sapiens

<400> 1454
Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu Leu Pro Ala Arg
 1               5                  10                  15
Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro Thr Ser Ser Glu
            20                  25                  30
Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro Pro Lys Ala Ala
        35                  40                  45
Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys Ser Pro Leu Gly
    50                  55                  60
Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala Arg Pro Ala Ala
65                  70                  75                  80
Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro Leu Ser Leu Ala
                85                  90                  95
Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His Val His Met Ser
            100                 105                 110
Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Leu Thr Phe
        115                 120                 125
Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala Asp Val Thr Gln
    130                 135                 140
Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln Thr Gly Leu Gln
145                 150                 155                 160
Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala Ala Ala Val Leu
                165                 170                 175
Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser Val Leu Leu Thr
            180                 185                 190
Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val Ala Leu Ala Val
        195                 200                 205
Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu
    210                 215                 220
Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr
225                 230                 235                 240
Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser Leu Phe Asn Arg
                245                 250                 255
Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln
            260                 265                 270
Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro
        275                 280                 285
Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp Ile Ser Thr Gly
    290                 295                 300
His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg Asn Arg Asp Arg
305                 310                 315                 320
Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn
                325                 330                 335
Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys Lys Asn Arg His
            340                 345                 350
Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys Leu Lys Val Glu
        355                 360                 365
Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser Pro Ile Ile Glu
    370                 375                 380
His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser
385                 390                 395                 400
His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr
                405                 410                 415
Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys
            420                 425                 430
Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr His Val Tyr Glu
        435                 440                 445
Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg
    450                 455                 460
Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr
465                 470                 475                 480
Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr Pro Ala Ser Thr
                485                 490                 495
Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly
            500                 505                 510
Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala Gly Arg Thr
        515                 520                 525
Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly
    530                 535                 540
Val Lys Glu Ile
545

<210> 1455
<211> 979
<212> PRT
<213> Homo sapiens

<400> 1455
Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu
 1               5                  10                  15
Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys
            20                  25                  30
Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser
        35                  40                  45
His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val
    50                  55                  60
Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu
65                  70                  75                  80
Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser
                85                  90                  95
Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg
            100                 105                 110
Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly
        115                 120                 125
Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp
    130                 135                 140
Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro
145                 150                 155                 160
Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu
                165                 170                 175
Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro
            180                 185                 190
Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro
        195                 200                 205
Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu
    210                 215                 220
Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala
225                 230                 235                 240
Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His
                245                 250                 255
Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu
            260                 265                 270
Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro
        275                 280                 285
Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg
    290                 295                 300
Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg
305                 310                 315                 320
Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln
                325                 330                 335
Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu
            340                 345                 350
Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro
        355                 360                 365
Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp
    370                 375                 380
Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu
385                 390                 395                 400
Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro
                405                 410                 415
Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro
            420                 425                 430
Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys
        435                 440                 445
Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala
    450                 455                 460
Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro
465                 470                 475                 480
Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His
                485                 490                 495
Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro
            500                 505                 510
Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala
        515                 520                 525
Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln
    530                 535                 540
Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala
545                 550                 555                 560
Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser
                565                 570                 575
Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val
            580                 585                 590
Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp
        595                 600                 605
Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr
    610                 615                 620
Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser
625                 630                 635                 640
Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser
                645                 650                 655
Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His
            660                 665                 670
Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp
        675                 680                 685
Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg
    690                 695                 700
Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln
705                 710                 715                 720
Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys
                725                 730                 735
Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys
            740                 745                 750
Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser
        755                 760                 765
Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln
    770                 775                 780
Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu
785                 790                 795                 800
Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly
                805                 810                 815
Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr
            820                 825                 830
His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp
        835                 840                 845
Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr
    850                 855                 860
Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr
865                 870                 875                 880
Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys
                885                 890                 895
Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly
            900                 905                 910
Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg
        915                 920                 925
Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His
    930                 935                 940
Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu
945                 950                 955                 960
Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala
                965                 970                 975
Leu Pro Gln


<210> 1456
<211> 548
<212> PRT
<213> Homo sapiens

<400> 1456
Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu Leu Pro Ala Arg
 1               5                  10                  15
Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro Thr Ser Ser Glu
            20                  25                  30
Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro Pro Lys Ala Ala
        35                  40                  45
Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys Ser Pro Leu Gly
    50                  55                  60
Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala Arg Pro Ala Ala
65                  70                  75                  80
Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro Leu Ser Leu Ala
                85                  90                  95
Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His Val His Met Ser
            100                 105                 110
Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Leu Thr Phe
        115                 120                 125
Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala Asp Val Thr Gln
    130                 135                 140
Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln Thr Gly Leu Gln
145                 150                 155                 160
Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala Ala Ala Val Leu
                165                 170                 175
Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser Val Leu Leu Thr
            180                 185                 190
Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val Ala Leu Ala Val
        195                 200                 205
Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu
    210                 215                 220
Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr
225                 230                 235                 240
Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser Leu Phe Asn Arg
                245                 250                 255
Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln
            260                 265                 270
Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro
        275                 280                 285
Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp Ile Ser Thr Gly
    290                 295                 300
His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg Asn Arg Asp Arg
305                 310                 315                 320
Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn
                325                 330                 335
Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys Lys Asn Arg His
            340                 345                 350
Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys Leu Lys Val Glu
        355                 360                 365
Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser Pro Ile Ile Glu
    370                 375                 380
His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser
385                 390                 395                 400
His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr
                405                 410                 415
Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys
            420                 425                 430
Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr His Val Tyr Glu
        435                 440                 445
Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg
    450                 455                 460
Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr
465                 470                 475                 480
Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr Pro Ala Ser Thr
                485                 490                 495
Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly
            500                 505                 510
Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala Gly Arg Thr
        515                 520                 525
Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly
    530                 535                 540
Val Lys Glu Ile
545

<210> 1457
<211> 548
<212> PRT
<213> Homo sapiens

<400> 1457
Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu Leu Pro Ala Arg
 1               5                  10                  15
Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro Thr Ser Ser Glu
            20                  25                  30
Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro Pro Lys Ala Ala
        35                  40                  45
Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys Ser Pro Leu Gly
    50                  55                  60
Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala Arg Pro Ala Ala
65                  70                  75                  80
Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro Leu Ser Leu Ala
                85                  90                  95
Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His Val His Met Ser
            100                 105                 110
Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Leu Thr Phe
        115                 120                 125
Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala Asp Val Thr Gln
    130                 135                 140
Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln Thr Gly Leu Gln
145                 150                 155                 160
Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala Ala Ala Val Leu
                165                 170                 175
Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser Val Leu Leu Thr
            180                 185                 190
Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val Ala Leu Ala Val
        195                 200                 205
Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu
    210                 215                 220
Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr
225                 230                 235                 240
Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser Leu Phe Asn Arg
                245                 250                 255
Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln
            260                 265                 270
Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro
        275                 280                 285
Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp Ile Ser Thr Gly
    290                 295                 300
His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg Asn Arg Asp Arg
305                 310                 315                 320
Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn
                325                 330                 335
Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys Lys Asn Arg His
            340                 345                 350
Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys Leu Lys Val Glu
        355                 360                 365
Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser Pro Ile Ile Glu
    370                 375                 380
His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser
385                 390                 395                 400
His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr
                405                 410                 415
Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys
            420                 425                 430
Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr His Val Tyr Glu
        435                 440                 445
Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg
    450                 455                 460
Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr
465                 470                 475                 480
Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr Pro Ala Ser Thr
                485                 490                 495
Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly
            500                 505                 510
Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala Gly Arg Thr
        515                 520                 525
Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly
    530                 535                 540
Val Lys Glu Ile
545

<210> 1458
<211> 548
<212> PRT
<213> Homo sapiens

<400> 1458
Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu Leu Pro Ala Arg
 1               5                  10                  15
Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro Thr Ser Ser Glu
            20                  25                  30
Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro Pro Lys Ala Ala
        35                  40                  45
Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys Ser Pro Leu Gly
    50                  55                  60
Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala Arg Pro Ala Ala
65                  70                  75                  80
Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro Leu Ser Leu Ala
                85                  90                  95
Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His Val His Met Ser
            100                 105                 110
Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Leu Thr Phe
        115                 120                 125
Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala Asp Val Thr Gln
    130                 135                 140
Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln Thr Gly Leu Gln
145                 150                 155                 160
Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala Ala Ala Val Leu
                165                 170                 175
Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser Val Leu Leu Thr
            180                 185                 190
Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val Ala Leu Ala Val
        195                 200                 205
Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu
    210                 215                 220
Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr
225                 230                 235                 240
Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser Leu Phe Asn Arg
                245                 250                 255
Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln
            260                 265                 270
Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro
        275                 280                 285
Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp Ile Ser Thr Gly
    290                 295                 300
His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg Asn Arg Asp Arg
305                 310                 315                 320
Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn
                325                 330                 335
Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys Lys Asn Arg His
            340                 345                 350
Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys Leu Lys Val Glu
        355                 360                 365
Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser Pro Ile Ile Glu
    370                 375                 380
His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser
385                 390                 395                 400
His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr
                405                 410                 415
Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys
            420                 425                 430
Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr His Val Tyr Glu
        435                 440                 445
Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg
    450                 455                 460
Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr
465                 470                 475                 480
Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr Pro Ala Ser Thr
                485                 490                 495
Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly
            500                 505                 510
Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala Gly Arg Thr
        515                 520                 525
Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly
    530                 535                 540
Val Lys Glu Ile
545

<210> 1459
<211> 979
<212> PRT
<213> Homo sapiens

<400> 1459
Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu
 1               5                  10                  15
Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys
            20                  25                  30
Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser
        35                  40                  45
His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val
    50                  55                  60
Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu
65                  70                  75                  80
Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser
                85                  90                  95
Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg
            100                 105                 110
Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly
        115                 120                 125
Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp
    130                 135                 140
Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro
145                 150                 155                 160
Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu
                165                 170                 175
Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro
            180                 185                 190
Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro
        195                 200                 205
Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu
    210                 215                 220
Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala
225                 230                 235                 240
Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His
                245                 250                 255
Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu
            260                 265                 270
Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro
        275                 280                 285
Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg
    290                 295                 300
Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg
305                 310                 315                 320
Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln
                325                 330                 335
Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu
            340                 345                 350
Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro
        355                 360                 365
Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp
    370                 375                 380
Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu
385                 390                 395                 400
Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro
                405                 410                 415
Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro
            420                 425                 430
Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys
        435                 440                 445
Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala
    450                 455                 460
Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro
465                 470                 475                 480
Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His
                485                 490                 495
Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro
            500                 505                 510
Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala
        515                 520                 525
Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln
    530                 535                 540
Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala
545                 550                 555                 560
Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser
                565                 570                 575
Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val
            580                 585                 590
Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp
        595                 600                 605
Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr
    610                 615                 620
Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser
625                 630                 635                 640
Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser
                645                 650                 655
Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His
            660                 665                 670
Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp
        675                 680                 685
Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg
    690                 695                 700
Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln
705                 710                 715                 720
Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys
                725                 730                 735
Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys
            740                 745                 750
Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser
        755                 760                 765
Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln
    770                 775                 780
Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu
785                 790                 795                 800
Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly
                805                 810                 815
Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr
            820                 825                 830
His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp
        835                 840                 845
Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr
    850                 855                 860
Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr
865                 870                 875                 880
Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys
                885                 890                 895
Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly
            900                 905                 910
Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg
        915                 920                 925
Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His
    930                 935                 940
Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu
945                 950                 955                 960
Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala
                965                 970                 975
Leu Pro Gln


<210> 1460
<211> 979
<212> PRT
<213> Homo sapiens

<400> 1460
Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu
 1               5                  10                  15
Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys
            20                  25                  30
Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser
        35                  40                  45
His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val
    50                  55                  60
Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu
65                  70                  75                  80
Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser
                85                  90                  95
Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg
            100                 105                 110
Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly
        115                 120                 125
Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp
    130                 135                 140
Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro
145                 150                 155                 160
Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu
                165                 170                 175
Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro
            180                 185                 190
Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro
        195                 200                 205
Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu
    210                 215                 220
Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala
225                 230                 235                 240
Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His
                245                 250                 255
Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu
            260                 265                 270
Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro
        275                 280                 285
Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg
    290                 295                 300
Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg
305                 310                 315                 320
Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln
                325                 330                 335
Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu
            340                 345                 350
Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro
        355                 360                 365
Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp
    370                 375                 380
Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu
385                 390                 395                 400
Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro
                405                 410                 415
Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro
            420                 425                 430
Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys
        435                 440                 445
Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala
    450                 455                 460
Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro
465                 470                 475                 480
Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His
                485                 490                 495
Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro
            500                 505                 510
Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala
        515                 520                 525
Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln
    530                 535                 540
Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala
545                 550                 555                 560
Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser
                565                 570                 575
Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val
            580                 585                 590
Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp
        595                 600                 605
Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr
    610                 615                 620
Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser
625                 630                 635                 640
Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser
                645                 650                 655
Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His
            660                 665                 670
Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp
        675                 680                 685
Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg
    690                 695                 700
Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln
705                 710                 715                 720
Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys
                725                 730                 735
Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys
            740                 745                 750
Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser
        755                 760                 765
Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln
    770                 775                 780
Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu
785                 790                 795                 800
Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly
                805                 810                 815
Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr
            820                 825                 830
His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp
        835                 840                 845
Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr
    850                 855                 860
Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr
865                 870                 875                 880
Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys
                885                 890                 895
Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly
            900                 905                 910
Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg
        915                 920                 925
Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His
    930                 935                 940
Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu
945                 950                 955                 960
Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala
                965                 970                 975
Leu Pro Gln


<210> 1461
<211> 591
<212> PRT
<213> Homo sapiens

<400> 1461
Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu Leu Pro Ala Arg
 1               5                  10                  15
Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro Thr Ser Ser Glu
            20                  25                  30
Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro Pro Lys Ala Ala
        35                  40                  45
Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys Ser Pro Leu Gly
    50                  55                  60
Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala Arg Pro Ala Ala
65                  70                  75                  80
Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro Leu Ser Leu Ala
                85                  90                  95
Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His Val His Met Ser
            100                 105                 110
Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Leu Thr Phe
        115                 120                 125
Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala Asp Val Thr Gln
    130                 135                 140
Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln Thr Gly Leu Gln
145                 150                 155                 160
Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala Ala Ala Val Leu
                165                 170                 175
Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser Val Leu Leu Thr
            180                 185                 190
Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val Ala Leu Ala Val
        195                 200                 205
Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu
    210                 215                 220
Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr
225                 230                 235                 240
Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser Leu Phe Asn Arg
                245                 250                 255
Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln
            260                 265                 270
Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro
        275                 280                 285
Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp Ile Ser Thr Gly
    290                 295                 300
His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg Asn Arg Asp Arg
305                 310                 315                 320
Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn
                325                 330                 335
Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys Lys Asn Arg His
            340                 345                 350
Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys Leu Lys Val Glu
        355                 360                 365
Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser Pro Ile Ile Glu
    370                 375                 380
His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser
385                 390                 395                 400
His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr
                405                 410                 415
Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys
            420                 425                 430
Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr His Val Tyr Glu
        435                 440                 445
Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg
    450                 455                 460
Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr
465                 470                 475                 480
Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr Pro Ala Ser Thr
                485                 490                 495
Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly
            500                 505                 510
Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala Gly Arg Thr
        515                 520                 525
Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly
    530                 535                 540
Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His Val Arg Asp Gln
545                 550                 555                 560
Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu Phe Ala Leu Thr
                565                 570                 575
Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala Leu Pro Gln
            580                 585                 590

<210> 1462
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1462
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 1463
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1463
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1464
<211> 698
<212> PRT
<213> Homo sapiens

<400> 1464
Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln Arg Leu Leu Leu
 1               5                  10                  15
Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr Thr Ala Lys Leu
            20                  25                  30
Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu
        35                  40                  45
Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser Trp Tyr
    50                  55                  60
Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr Val Ile
65                  70                  75                  80
Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg Glu Ile
                85                  90                  95
Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln Asn Asp
            100                 105                 110
Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val Asn Glu
        115                 120                 125
Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro Lys Pro Ser
    130                 135                 140
Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala
145                 150                 155                 160
Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp Trp Val
                165                 170                 175
Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly
            180                 185                 190
Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Thr Ala Ser
        195                 200                 205
Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser Asp Ser
    210                 215                 220
Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro Thr Ile Ser Pro
225                 230                 235                 240
Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn Leu Ser Cys His
                245                 250                 255
Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Val Asn Gly Thr
            260                 265                 270
Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr Val Asn
        275                 280                 285
Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser Asp Thr Gly Leu
    290                 295                 300
Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala Glu Pro Pro Lys
305                 310                 315                 320
Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Glu Asp Ala
                325                 330                 335
Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr Tyr Leu Trp
            340                 345                 350
Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser
        355                 360                 365
Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Val
    370                 375                 380
Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val Asp His Ser
385                 390                 395                 400
Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile
                405                 410                 415
Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser
            420                 425                 430
Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp
        435                 440                 445
Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr
    450                 455                 460
Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser
465                 470                 475                 480
Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala Glu Leu
                485                 490                 495
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
            500                 505                 510
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr
        515                 520                 525
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
    530                 535                 540
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
545                 550                 555                 560
Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser Ala Asn
                565                 570                 575
Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro
            580                 585                 590
Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn
        595                 600                 605
Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg
    610                 615                 620
Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys
625                 630                 635                 640
Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu
                645                 650                 655
Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala
            660                 665                 670
Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly Ile Met
        675                 680                 685
Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695

<210> 1465
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1465
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Ile Ile Arg Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Leu Ile Ala Lys Ile Gln Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Ala Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 1466
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1466
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 1467
<211> 287
<212> PRT
<213> Homo sapiens

<400> 1467
Gly Leu His Asn His His Pro Ile Lys Pro Phe Ile Thr Ser Asn Asn
 1               5                  10                  15
Ser Asn Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro
            20                  25                  30
Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
        35                  40                  45
Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr
    50                  55                  60
Leu Leu Ser Val Thr Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile
65                  70                  75                  80
Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val
                85                  90                  95
Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr
            100                 105                 110
Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro
        115                 120                 125
Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr
    130                 135                 140
Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr
145                 150                 155                 160
Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val
                165                 170                 175
Lys Thr Ile Thr Val Ser Ala Asp Val Pro Lys Pro Ser Ile Ser Ser
            180                 185                 190
Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe His Cys
        195                 200                 205
Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln
    210                 215                 220
Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr
225                 230                 235                 240
Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys
                245                 250                 255
Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu
            260                 265                 270
Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Pro
        275                 280                 285

<210> 1468
<211> 372
<212> PRT
<213> Homo sapiens

<400> 1468
Asn Ser Asn Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu
 1               5                  10                  15
Pro Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser
            20                  25                  30
Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu
        35                  40                  45
Thr Leu Leu Ser Val Thr Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly
    50                  55                  60
Ile Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn
65                  70                  75                  80
Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr
                85                  90                  95
Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn
            100                 105                 110
Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His
        115                 120                 125
Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu
    130                 135                 140
Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr
145                 150                 155                 160
Val Lys Thr Ile Thr Val Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser
                165                 170                 175
Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr
            180                 185                 190
Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly
        195                 200                 205
Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg
    210                 215                 220
Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val
225                 230                 235                 240
Cys Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr
                245                 250                 255
Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp
            260                 265                 270
Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn Leu Ser Cys His Ser Ala
        275                 280                 285
Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln
    290                 295                 300
Gln His Thr Gln Val Leu Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn
305                 310                 315                 320
Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn
                325                 330                 335
Ser Ile Val Lys Ser Ile Thr Val Ser Ala Ser Gly Thr Ser Pro Gly
            340                 345                 350
Leu Ser Ala Gly Ala Thr Val Gly Ile Met Ile Gly Val Leu Val Gly
        355                 360                 365
Val Ala Leu Ile
    370

<210> 1469
<211> 349
<212> PRT
<213> Homo sapiens

<400> 1469
Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val
            100                 105                 110
Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn
        115                 120                 125
Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
        195                 200                 205
Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser
    290                 295                 300
Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp
305                 310                 315                 320
Ala Val Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val
                325                 330                 335
Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile
            340                 345

<210> 1470
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1470
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Leu His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1471
<211> 349
<212> PRT
<213> Homo sapiens

<400> 1471
Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val
            100                 105                 110
Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn
        115                 120                 125
Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
        195                 200                 205
Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser
    290                 295                 300
Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp
305                 310                 315                 320
Ala Val Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val
                325                 330                 335
Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile
            340                 345

<210> 1472
<211> 698
<212> PRT
<213> Homo sapiens

<400> 1472
Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln Arg Leu Leu Leu
 1               5                  10                  15
Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr Thr Ala Lys Leu
            20                  25                  30
Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu
        35                  40                  45
Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser Trp Tyr
    50                  55                  60
Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr Val Ile
65                  70                  75                  80
Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg Glu Ile
                85                  90                  95
Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln Asn Asp
            100                 105                 110
Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val Asn Glu
        115                 120                 125
Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro Lys Pro Ser
    130                 135                 140
Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala
145                 150                 155                 160
Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp Trp Val
                165                 170                 175
Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly
            180                 185                 190
Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Thr Ala Ser
        195                 200                 205
Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser Asp Ser
    210                 215                 220
Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro Thr Ile Ser Pro
225                 230                 235                 240
Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn Leu Ser Cys His
                245                 250                 255
Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Val Asn Gly Thr
            260                 265                 270
Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr Val Asn
        275                 280                 285
Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser Asp Thr Gly Leu
    290                 295                 300
Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala Glu Pro Pro Lys
305                 310                 315                 320
Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Glu Asp Ala
                325                 330                 335
Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr Tyr Leu Trp
            340                 345                 350
Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser
        355                 360                 365
Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Val
    370                 375                 380
Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val Asp His Ser
385                 390                 395                 400
Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile
                405                 410                 415
Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser
            420                 425                 430
Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp
        435                 440                 445
Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr
    450                 455                 460
Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser
465                 470                 475                 480
Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala Glu Leu
                485                 490                 495
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
            500                 505                 510
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr
        515                 520                 525
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
    530                 535                 540
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
545                 550                 555                 560
Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser Ala Asn
                565                 570                 575
Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro
            580                 585                 590
Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn
        595                 600                 605
Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg
    610                 615                 620
Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys
625                 630                 635                 640
Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu
                645                 650                 655
Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala
            660                 665                 670
Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly Ile Met
        675                 680                 685
Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695

<210> 1473
<211> 349
<212> PRT
<213> Homo sapiens

<400> 1473
Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val
            100                 105                 110
Thr Lys Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn
        115                 120                 125
Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
        195                 200                 205
Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser
    290                 295                 300
Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp
305                 310                 315                 320
Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val
                325                 330                 335
Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile
            340                 345

<210> 1474
<211> 349
<212> PRT
<213> Homo sapiens

<400> 1474
Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val
            100                 105                 110
Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn
        115                 120                 125
Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
        195                 200                 205
Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser
    290                 295                 300
Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp
305                 310                 315                 320
Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val
                325                 330                 335
Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile
            340                 345

<210> 1475
<211> 697
<212> PRT
<213> Homo sapiens

<400> 1475
Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln Arg Leu Leu Leu
 1               5                  10                  15
Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr Thr Ala Lys Leu
            20                  25                  30
Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu
        35                  40                  45
Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser Trp Tyr
    50                  55                  60
Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr Val Ile
65                  70                  75                  80
Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg Glu Ile
                85                  90                  95
Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln Asn Asp
            100                 105                 110
Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val Asn Glu
        115                 120                 125
Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro Lys Pro Ser
    130                 135                 140
Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala
145                 150                 155                 160
Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp Trp Val
                165                 170                 175
Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly
            180                 185                 190
Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Thr Ala Ser
        195                 200                 205
Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser Asp Ser
    210                 215                 220
Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro Thr Ile Ser Pro
225                 230                 235                 240
Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn Leu Ser Cys His
                245                 250                 255
Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Val Asn Gly Thr
            260                 265                 270
Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr Val Asn
        275                 280                 285
Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser Asp Thr Gly Leu
    290                 295                 300
Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Glu Pro Pro Lys Pro
305                 310                 315                 320
Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Glu Asp Ala Val
                325                 330                 335
Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp
            340                 345                 350
Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn
        355                 360                 365
Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Val Gly
    370                 375                 380
Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val Asp His Ser Asp
385                 390                 395                 400
Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser
                405                 410                 415
Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser Cys
            420                 425                 430
His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly
        435                 440                 445
Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu
    450                 455                 460
Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly
465                 470                 475                 480
His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala Glu Leu Pro
                485                 490                 495
Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp
            500                 505                 510
Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu
        515                 520                 525
Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu
    530                 535                 540
Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp
545                 550                 555                 560
Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser Ala Asn Arg
                565                 570                 575
Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile
            580                 585                 590
Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn Leu
        595                 600                 605
Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg Ile
    610                 615                 620
Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys Ile
625                 630                 635                 640
Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala
                645                 650                 655
Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala Ser
            660                 665                 670
Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly Ile Met Ile
        675                 680                 685
Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695

<210> 1476
<211> 737
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(737)
<223> Xaa = Any Amino Acid

<400> 1476
Xaa His Ala Ser Ala Ala Xaa Pro Thr Val Thr Ala Ala Leu Thr Arg
 1               5                  10                  15
Ala Phe Leu Glu Leu Lys Leu Ser Thr Lys Arg Trp Thr Glu Lys Thr
            20                  25                  30
Ala Glu Thr Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val
        35                  40                  45
Pro Trp Lys Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn
    50                  55                  60
Pro Pro Thr Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val
65                  70                  75                  80
Ala Glu Gly Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn
                85                  90                  95
Arg Ile Gly Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser
            100                 105                 110
Leu Ile Val Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro
        115                 120                 125
Ala Tyr Ser Gly Arg Glu Thr Ile Tyr Pro Asn Xaa Ser Leu Leu Ile
    130                 135                 140
Gln Asn Val Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile
145                 150                 155                 160
Lys Ser Asp Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr
                165                 170                 175
Pro Glu Leu Pro Lys Pro Ser Ile Ser Xaa Asn Asn Ser Asn Pro Val
            180                 185                 190
Glu Xaa Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn
        195                 200                 205
Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro
    210                 215                 220
Arg Leu Gln Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val
225                 230                 235                 240
Lys Arg Asn Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala
                245                 250                 255
Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro
            260                 265                 270
Asp Gly Pro Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu
        275                 280                 285
Asn Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr
    290                 295                 300
Ser Trp Phe Xaa Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe
305                 310                 315                 320
Ile Pro Asn Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala
                325                 330                 335
His Asn Ser Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr
            340                 345                 350
Val Tyr Ala Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn
        355                 360                 365
Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile
    370                 375                 380
Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val
385                 390                 395                 400
Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu
                405                 410                 415
Ser Val Thr Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn
            420                 425                 430
Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr
        435                 440                 445
Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro
    450                 455                 460
Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala
465                 470                 475                 480
Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu
                485                 490                 495
Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys
            500                 505                 510
Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr
        515                 520                 525
Ile Thr Val Ser Ala Xaa Xaa Pro Lys Pro Ser Ile Ser Ser Asn Asn
    530                 535                 540
Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro
545                 550                 555                 560
Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu
                565                 570                 575
Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr
            580                 585                 590
Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile
        595                 600                 605
Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val
    610                 615                 620
Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr
625                 630                 635                 640
Leu Ser Gly Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro
                645                 650                 655
Ser Pro Gln Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr
            660                 665                 670
Gln Val Leu Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr
        675                 680                 685
Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val
    690                 695                 700
Lys Ser Ile Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala
705                 710                 715                 720
Gly Ala Thr Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu
                725                 730                 735
Ile


<210> 1477
<211> 156
<212> PRT
<213> Homo sapiens

<400> 1477
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys
            100                 105                 110
Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala
        115                 120                 125
Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr Leu Trp
    130                 135                 140
Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Lys
145                 150                 155

<210> 1478
<211> 796
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(796)
<223> Xaa = Any Amino Acid

<400> 1478
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Asp Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile Xaa Gln
    690                 695                 700
Pro Trp Cys Ser Phe Phe Ile Ser Gly Arg Leu Thr Val Val Leu Leu
705                 710                 715                 720
Leu Pro Xaa Ser Ile Cys Asn Ser Tyr Ser Leu Lys Leu Leu Leu Tyr
                725                 730                 735
Gln Gly Tyr Leu Gln Lys Arg Leu Xaa Pro Glu Ile Glu Thr Ile Leu
            740                 745                 750
Ala Asn Ile Val Lys Pro His Leu Tyr Xaa Lys Tyr Lys Asn Glu Leu
        755                 760                 765
Gly Leu Val Ala Arg Thr Cys Ser Pro Ser Tyr Ser Gly Gly Xaa Gly
    770                 775                 780
Arg Arg Ile Ala Xaa Thr Pro Arg Ala Ala Gly Arg
785                 790                 795

<210> 1479
<211> 595
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(595)
<223> Xaa = Any Amino Acid

<400> 1479
Leu Ile Gln Asn Val Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu His
 1               5                  10                  15
Val Ile Lys Ser Asp Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg
            20                  25                  30
Val Tyr Pro Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys
        35                  40                  45
Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr
    50                  55                  60
Gln Asp Ala Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val
65                  70                  75                  80
Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe
                85                  90                  95
Asn Val Thr Arg Asn Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn
            100                 105                 110
Pro Val Ser Ala Arg Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr
        115                 120                 125
Gly Pro Asp Ala Pro Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser
    130                 135                 140
Gly Glu Asn Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala
145                 150                 155                 160
Gln Tyr Ser Trp Phe Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu
                165                 170                 175
Leu Phe Ile Pro Asn Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys
            180                 185                 190
Gln Ala His Asn Ser Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr
        195                 200                 205
Ile Thr Val Tyr Ala Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn
    210                 215                 220
Ser Asn Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro
225                 230                 235                 240
Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
                245                 250                 255
Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr
            260                 265                 270
Leu Leu Ser Val Thr Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile
        275                 280                 285
Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val
    290                 295                 300
Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr
305                 310                 315                 320
Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro
                325                 330                 335
Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr
            340                 345                 350
Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr
        355                 360                 365
Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val
    370                 375                 380
Lys Thr Ile Thr Val Ser Ala Xaa Xaa Pro Lys Pro Ser Ile Ser Ser
385                 390                 395                 400
Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys
                405                 410                 415
Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln
            420                 425                 430
Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr
        435                 440                 445
Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys
    450                 455                 460
Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu
465                 470                 475                 480
Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser
                485                 490                 495
Ser Tyr Leu Ser Gly Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser
            500                 505                 510
Asn Pro Ser Pro Gln Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln
        515                 520                 525
His Thr Gln Val Leu Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly
    530                 535                 540
Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser
545                 550                 555                 560
Ile Val Lys Ser Ile Thr Val Ser Ala Ser Xaa Thr Ser Pro Gly Leu
                565                 570                 575
Ser Ala Gly Ala Thr Val Gly Ile Met Ile Gly Val Leu Val Gly Val
            580                 585                 590
Ala Leu Ile
        595

<210> 1480
<211> 365
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(365)
<223> Xaa = Any Amino Acid

<400> 1480
Pro Glu His Ser Trp Ser Ser Ser Ser Ser Thr Lys Arg Trp Thr Glu
 1               5                  10                  15
Lys Thr Ala Glu Thr Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu
            20                  25                  30
His Val Pro Trp Lys Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe
        35                  40                  45
Trp Asn Pro Pro Thr Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe
    50                  55                  60
Asn Val Ala Glu Gly Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro
65                  70                  75                  80
Gln Asn Arg Ile Gly Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly
                85                  90                  95
Asn Ser Leu Ile Val Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro
            100                 105                 110
Gly Pro Ala Tyr Ser Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu
        115                 120                 125
Leu Ile Gln Asn Val Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln
    130                 135                 140
Val Ile Lys Ser Asp Leu Val Asn Glu Glu Xaa Thr Gly Gln Phe His
145                 150                 155                 160
Val Tyr Pro Glu Leu Pro Lys Pro Ser Ile Xaa Ser Asn Asn Ser Asn
                165                 170                 175
Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Xaa
            180                 185                 190
Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val
        195                 200                 205
Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu
    210                 215                 220
Ser Val Lys Arg Asn Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn
225                 230                 235                 240
Pro Ala Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr
                245                 250                 255
Gly Pro Asp Gly Pro Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro
            260                 265                 270
Gly Glu Asn Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala
        275                 280                 285
Gln Tyr Ser Trp Phe Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu
    290                 295                 300
Leu Phe Ile Pro Asn Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys
305                 310                 315                 320
Gln Ala His Asn Ser Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met
                325                 330                 335
Ile Thr Val Ser Gly Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val
            340                 345                 350
Gly Ile Thr Ile Gly Val Leu Ala Arg Val Ala Leu Ile
        355                 360                 365

<210> 1481
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1481
Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu
 1               5                  10

<210> 1482
<211> 698
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(698)
<223> Xaa = Any Amino Acid

<400> 1482
Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln Arg Leu Leu Leu
 1               5                  10                  15
Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr Thr Ala Lys Leu
            20                  25                  30
Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu
        35                  40                  45
Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser Trp Tyr
    50                  55                  60
Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr Val Ile
65                  70                  75                  80
Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg Glu Ile
                85                  90                  95
Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln Asn Asp
            100                 105                 110
Thr Gly Phe Tyr Thr Val His Val Ile Lys Ser Asp Leu Val Asn Glu
        115                 120                 125
Glu Ala Thr Gly Gln Phe Pro Val Tyr Pro Glu Leu Pro Lys Pro Ser
    130                 135                 140
Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala
145                 150                 155                 160
Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp Trp Val
                165                 170                 175
Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly
            180                 185                 190
Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Thr Ala Ser
        195                 200                 205
Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser Asp Ser
    210                 215                 220
Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro Thr Ile Ser Pro
225                 230                 235                 240
Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn Val Ser Cys His
                245                 250                 255
Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Val Asn Gly Thr
            260                 265                 270
Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr Val Asn
        275                 280                 285
Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser Asp Thr Gly Leu
    290                 295                 300
Asn Arg Thr Thr Val Thr Ser Ile Thr Val Tyr Ala Gln Pro Pro Lys
305                 310                 315                 320
Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Gln Asp Glu Asp Ala
                325                 330                 335
Val Ala Leu Thr Cys Glu Pro Gln Ile Gln Asn Thr Thr Xaa Leu Trp
            340                 345                 350
Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser
        355                 360                 365
Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Val
    370                 375                 380
Arg Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val Asp His Thr
385                 390                 395                 400
Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile
                405                 410                 415
Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser
            420                 425                 430
Cys His Ala Gly Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp
        435                 440                 445
Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr
    450                 455                 460
Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser
465                 470                 475                 480
Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala Glu Leu
                485                 490                 495
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
            500                 505                 510
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr
        515                 520                 525
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
    530                 535                 540
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
545                 550                 555                 560
Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser Ala Asn
                565                 570                 575
Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Arg Pro Asp Thr Pro
            580                 585                 590
Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn
        595                 600                 605
Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg
    610                 615                 620
Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys
625                 630                 635                 640
Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu
                645                 650                 655
Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala
            660                 665                 670
Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly Ile Met
        675                 680                 685
Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695

<210> 1483
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1483
Met Glu Ser Pro Ser Ala Pro Leu His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Glu Gln Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Ala Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Glu Val Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 1484
<211> 286
<212> PRT
<213> Homo sapiens

<400> 1484
Gly Leu His Asn His His Pro Ile Lys Pro Phe Ile Thr Ser Asn Asn
 1               5                  10                  15
Ser Asn Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro
            20                  25                  30
Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
        35                  40                  45
Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr
    50                  55                  60
Leu Leu Ser Val Thr Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile
65                  70                  75                  80
Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val
                85                  90                  95
Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr
            100                 105                 110
Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro
        115                 120                 125
Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr
    130                 135                 140
Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr
145                 150                 155                 160
Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val
                165                 170                 175
Lys Thr Ile Thr Val Ser Ala Asp Val Pro Lys Pro Ser Ile Ser Ser
            180                 185                 190
Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe His Cys
        195                 200                 205
Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln
    210                 215                 220
Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr
225                 230                 235                 240
Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys
                245                 250                 255
Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu
            260                 265                 270
Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro
        275                 280                 285

<210> 1485
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1485
Met Glu Ser Pro Ser Ala Pro Leu His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Glu His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asn Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Glu Gln Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Asp Val Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 1486
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1486
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1487
<211> 642
<212> PRT
<213> Homo sapiens

<400> 1487
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro Lys
            100                 105                 110
Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala
        115                 120                 125
Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp
    130                 135                 140
Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser
145                 150                 155                 160
Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Thr
                165                 170                 175
Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser
            180                 185                 190
Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro Thr Ile
        195                 200                 205
Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn Leu Ser
    210                 215                 220
Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Val Asn
225                 230                 235                 240
Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr
                245                 250                 255
Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser Asp Thr
            260                 265                 270
Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala Glu Pro
        275                 280                 285
Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Glu
    290                 295                 300
Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr Tyr
305                 310                 315                 320
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
                325                 330                 335
Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
            340                 345                 350
Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val Asp
        355                 360                 365
His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro
    370                 375                 380
Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser
385                 390                 395                 400
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu
                405                 410                 415
Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn
            420                 425                 430
Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser
        435                 440                 445
Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala
    450                 455                 460
Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu
465                 470                 475                 480
Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr
                485                 490                 495
Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg
            500                 505                 510
Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr
        515                 520                 525
Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser
    530                 535                 540
Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp
545                 550                 555                 560
Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn
                565                 570                 575
Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser
            580                 585                 590
Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile
        595                 600                 605
Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser
    610                 615                 620
Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val
625                 630                 635                 640
Ser Ala


<210> 1488
<211> 698
<212> PRT
<213> Homo sapiens

<400> 1488
Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln Arg Leu Leu Leu
 1               5                  10                  15
Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr Thr Ala Lys Leu
            20                  25                  30
Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu
        35                  40                  45
Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser Trp Tyr
    50                  55                  60
Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr Val Ile
65                  70                  75                  80
Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg Glu Ile
                85                  90                  95
Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln Asn Asp
            100                 105                 110
Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val Asn Glu
        115                 120                 125
Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro Lys Pro Ser
    130                 135                 140
Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala
145                 150                 155                 160
Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp Trp Val
                165                 170                 175
Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly
            180                 185                 190
Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Thr Ala Ser
        195                 200                 205
Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser Asp Ser
    210                 215                 220
Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro Thr Ile Ser Pro
225                 230                 235                 240
Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn Leu Ser Cys His
                245                 250                 255
Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Val Asn Gly Thr
            260                 265                 270
Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr Val Asn
        275                 280                 285
Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser Asp Thr Gly Leu
    290                 295                 300
Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala Glu Pro Pro Lys
305                 310                 315                 320
Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Glu Asp Ala
                325                 330                 335
Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr Tyr Leu Trp
            340                 345                 350
Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser
        355                 360                 365
Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Val
    370                 375                 380
Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val Asp His Ser
385                 390                 395                 400
Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile
                405                 410                 415
Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser
            420                 425                 430
Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp
        435                 440                 445
Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr
    450                 455                 460
Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser
465                 470                 475                 480
Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala Glu Leu
                485                 490                 495
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
            500                 505                 510
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr
        515                 520                 525
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
    530                 535                 540
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
545                 550                 555                 560
Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser Ala Asn
                565                 570                 575
Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro
            580                 585                 590
Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn
        595                 600                 605
Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg
    610                 615                 620
Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys
625                 630                 635                 640
Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu
                645                 650                 655
Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala
            660                 665                 670
Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly Ile Met
        675                 680                 685
Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695

<210> 1489
<211> 734
<212> PRT
<213> Homo sapiens

<400> 1489
Arg Pro Ala Asp Gln Thr Val Thr Ala Ala Leu Thr Lys Arg Ser Trp
 1               5                  10                  15
Asn Ser Ser Thr Ser Pro Gln Arg Arg Thr Glu Gln Thr Ala Glu Thr
            20                  25                  30
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
        35                  40                  45
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
    50                  55                  60
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
65                  70                  75                  80
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
                85                  90                  95
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
            100                 105                 110
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
        115                 120                 125
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
    130                 135                 140
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
145                 150                 155                 160
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
                165                 170                 175
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
            180                 185                 190
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
        195                 200                 205
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
    210                 215                 220
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
225                 230                 235                 240
Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
                245                 250                 255
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
            260                 265                 270
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
        275                 280                 285
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
    290                 295                 300
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
305                 310                 315                 320
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
                325                 330                 335
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
            340                 345                 350
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
        355                 360                 365
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
    370                 375                 380
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
385                 390                 395                 400
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
                405                 410                 415
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
            420                 425                 430
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
        435                 440                 445
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
    450                 455                 460
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
465                 470                 475                 480
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
                485                 490                 495
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
            500                 505                 510
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
        515                 520                 525
Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
    530                 535                 540
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
545                 550                 555                 560
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
                565                 570                 575
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
            580                 585                 590
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
        595                 600                 605
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
    610                 615                 620
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
625                 630                 635                 640
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
                645                 650                 655
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
            660                 665                 670
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
        675                 680                 685
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
    690                 695                 700
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
705                 710                 715                 720
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
                725                 730

<210> 1490
<211> 286
<212> PRT
<213> Homo sapiens

<400> 1490
Gly Leu His Asn His His Pro Ile Lys Pro Phe Ile Thr Ser Asn Asn
 1               5                  10                  15
Ser Asn Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro
            20                  25                  30
Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
        35                  40                  45
Ala Val Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr
    50                  55                  60
Leu Leu Ser Val Thr Ser Asn His Val Arg Pro Tyr Glu Cys Gly Ile
65                  70                  75                  80
Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val
                85                  90                  95
Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr
            100                 105                 110
Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro
        115                 120                 125
Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr
    130                 135                 140
Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr
145                 150                 155                 160
Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val
                165                 170                 175
Lys Thr Ile Thr Val Cys Ala Asp Val Pro Lys Pro Ser Ile Ser Ser
            180                 185                 190
Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe His Cys
        195                 200                 205
Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln
    210                 215                 220
Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr
225                 230                 235                 240
Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys
                245                 250                 255
Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu
            260                 265                 270
Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro
        275                 280                 285

<210> 1491
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1491
Met Glu Ser Pro Ser Ala Pro Leu His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Glu His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asn Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Glu Gln Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Asp Val Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 1492
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1492
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1493
<211> 698
<212> PRT
<213> Homo sapiens

<400> 1493
Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln Arg Leu Leu Leu
 1               5                  10                  15
Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr Thr Ala Lys Leu
            20                  25                  30
Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu
        35                  40                  45
Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser Trp Tyr
    50                  55                  60
Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr Val Ile
65                  70                  75                  80
Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg Glu Ile
                85                  90                  95
Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln Asn Asp
            100                 105                 110
Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val Asn Glu
        115                 120                 125
Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro Lys Pro Ser
    130                 135                 140
Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala
145                 150                 155                 160
Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp Trp Val
                165                 170                 175
Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly
            180                 185                 190
Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Thr Ala Ser
        195                 200                 205
Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser Asp Ser
    210                 215                 220
Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro Thr Ile Ser Pro
225                 230                 235                 240
Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn Leu Ser Cys His
                245                 250                 255
Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Val Asn Gly Thr
            260                 265                 270
Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr Val Asn
        275                 280                 285
Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser Asp Thr Gly Leu
    290                 295                 300
Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala Glu Pro Pro Lys
305                 310                 315                 320
Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Glu Asp Ala
                325                 330                 335
Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr Tyr Leu Trp
            340                 345                 350
Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser
        355                 360                 365
Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Val
    370                 375                 380
Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val Asp His Ser
385                 390                 395                 400
Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile
                405                 410                 415
Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser
            420                 425                 430
Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp
        435                 440                 445
Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr
    450                 455                 460
Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser
465                 470                 475                 480
Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala Glu Leu
                485                 490                 495
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
            500                 505                 510
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr
        515                 520                 525
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
    530                 535                 540
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
545                 550                 555                 560
Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser Ala Asn
                565                 570                 575
Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro
            580                 585                 590
Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn
        595                 600                 605
Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg
    610                 615                 620
Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys
625                 630                 635                 640
Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu
                645                 650                 655
Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala
            660                 665                 670
Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly Ile Met
        675                 680                 685
Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695

<210> 1494
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1494
Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu
 1               5                  10

<210> 1495
<211> 286
<212> PRT
<213> Homo sapiens

<400> 1495
Gly Leu His Asn His His Pro Ile Lys Pro Phe Ile Thr Ser Asn Asn
 1               5                  10                  15
Ser Asn Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro
            20                  25                  30
Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
        35                  40                  45
Ala Val Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr
    50                  55                  60
Leu Leu Ser Val Thr Arg Asn His Val Gly Pro Tyr Glu Cys Gly Ile
65                  70                  75                  80
Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Val Asn Val
                85                  90                  95
Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr
            100                 105                 110
Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Ser Pro
        115                 120                 125
Pro Ala Glu Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr
    130                 135                 140
Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr
145                 150                 155                 160
Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val
                165                 170                 175
Lys Thr Ile Thr Val Ser Ala Asp Val Pro Lys Pro Ser Ile Ser Ser
            180                 185                 190
Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe His Cys
        195                 200                 205
Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln
    210                 215                 220
Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr
225                 230                 235                 240
Leu Thr Val Phe Asn Val Thr Arg Asn Asp Gly Arg Ala Tyr Val Cys
                245                 250                 255
Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu
            260                 265                 270
Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro
        275                 280                 285

<210> 1496
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1496
Met Glu Ser Pro Ser Ala Pro Leu His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Glu His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asn Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Glu Gln Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Ala
                485                 490                 495
Ser Ala Asp Val Pro Lys Arg Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Arg Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 1497
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1497
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Leu Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Cys Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1498
<211> 156
<212> PRT
<213> Homo sapiens

<400> 1498
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys
            100                 105                 110
Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala
        115                 120                 125
Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr Leu Trp
    130                 135                 140
Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Lys
145                 150                 155

<210> 1499
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1499
Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu
 1               5                  10

<210> 1500
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1500
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 1501
<211> 349
<212> PRT
<213> Homo sapiens

<400> 1501
Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val
            100                 105                 110
Thr Lys Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn
        115                 120                 125
Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
        195                 200                 205
Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser
    290                 295                 300
Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp
305                 310                 315                 320
Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val
                325                 330                 335
Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile
            340                 345

<210> 1502
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1502
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Leu His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1503
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1503
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 1504
<211> 349
<212> PRT
<213> Homo sapiens

<400> 1504
Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val
            100                 105                 110
Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn
        115                 120                 125
Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
        195                 200                 205
Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser
    290                 295                 300
Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp
305                 310                 315                 320
Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val
                325                 330                 335
Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile
            340                 345

<210> 1505
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1505
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Leu His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1506
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1506
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1507
<211> 287
<212> PRT
<213> Homo sapiens

<400> 1507
Gly Leu His Asn His His Pro Ile Lys Pro Phe Ile Thr Ser Asn Asn
 1               5                  10                  15
Ser Asn Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro
            20                  25                  30
Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
        35                  40                  45
Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr
    50                  55                  60
Leu Leu Ser Val Thr Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile
65                  70                  75                  80
Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val
                85                  90                  95
Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr
            100                 105                 110
Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro
        115                 120                 125
Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr
    130                 135                 140
Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr
145                 150                 155                 160
Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val
                165                 170                 175
Lys Thr Ile Thr Val Ser Ala Asp Val Pro Lys Pro Ser Ile Ser Ser
            180                 185                 190
Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe His Cys
        195                 200                 205
Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln
    210                 215                 220
Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr
225                 230                 235                 240
Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys
                245                 250                 255
Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu
            260                 265                 270
Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Pro
        275                 280                 285

<210> 1508
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1508
Ile Met Ile Gly Val Leu Val Gly Val
 1               5

<210> 1509
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1509
Gly Ile Met Ile Gly Val Leu Val Gly Val
 1               5                  10

<210> 1510
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1510
Ile Met Ile Gly Val Leu Val Gly Val
 1               5

<210> 1511
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1511
Ile Met Ile Gly Val Leu Val Gly Val Ala
 1               5                  10

<210> 1512
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1512
Ile Met Ile Gly Val Leu Val Gly Val
 1               5

<210> 1513
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1513
Gly Ile Met Ile Gly Val Leu Val Gly Val
 1               5                  10

<210> 1514
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1514
Ile Met Ile Gly Val Leu Val Gly Val Ala
 1               5                  10

<210> 1515
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1515
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1516
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1516
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1517
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1517
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1518
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1518
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Leu Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1519
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1519
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Ile Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1520
<211> 150
<212> PRT
<213> Homo sapiens

<400> 1520
Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro Tyr Ile Asn
 1               5                  10                  15
Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser
            20                  25                  30
Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile Leu Ser
        35                  40                  45
Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile Ala Gly Ile
    50                  55                  60
Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys Ser Asn Ile
65                  70                  75                  80
Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile Glu Ile Lys
                85                  90                  95
Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn Glu
            100                 105                 110
Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu Glu Thr
        115                 120                 125
Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser Ser Pro Ile
    130                 135                 140
Glu Asn Asp Ser Ser Pro
145                 150

<210> 1521
<211> 150
<212> PRT
<213> Homo sapiens

<400> 1521
Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro Tyr Ile Asn
 1               5                  10                  15
Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser
            20                  25                  30
Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile Leu Ser
        35                  40                  45
Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile Ala Gly Ile
    50                  55                  60
Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys Ser Asn Ile
65                  70                  75                  80
Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile Glu Ile Lys
                85                  90                  95
Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn Glu
            100                 105                 110
Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu Glu Thr
        115                 120                 125
Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser Ser Pro Ile
    130                 135                 140
Glu Asn Asp Ser Ser Pro
145                 150

<210> 1522
<211> 150
<212> PRT
<213> Homo sapiens

<400> 1522
Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro Tyr Ile Asn
 1               5                  10                  15
Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser
            20                  25                  30
Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile Leu Ser
        35                  40                  45
Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile Ala Gly Ile
    50                  55                  60
Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys Ser Asn Ile
65                  70                  75                  80
Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile Glu Ile Lys
                85                  90                  95
Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn Glu
            100                 105                 110
Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu Glu Thr
        115                 120                 125
Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser Ser Pro Ile
    130                 135                 140
Glu Asn Asp Ser Ser Pro
145                 150

<210> 1523
<211> 150
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(150)
<223> Xaa = Any Amino Acid

<400> 1523
Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro Tyr Ile Asn
 1               5                  10                  15
Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser
            20                  25                  30
Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile Leu Ser
        35                  40                  45
Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile Ala Gly Ile
    50                  55                  60
Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys Ser Asn Ile
65                  70                  75                  80
Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile Glu Ile Lys
                85                  90                  95
Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn Glu
            100                 105                 110
Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu Glu Thr
        115                 120                 125
Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser Ser Xaa Ile
    130                 135                 140
Glu Asn Asp Ser Ser Pro
145                 150

<210> 1524
<211> 150
<212> PRT
<213> Homo sapiens

<400> 1524
Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro Tyr Ile Asn
 1               5                  10                  15
Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser
            20                  25                  30
Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile Leu Ser
        35                  40                  45
Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile Ala Gly Ile
    50                  55                  60
Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys Ser Asn Ile
65                  70                  75                  80
Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile Glu Ile Lys
                85                  90                  95
Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn Glu
            100                 105                 110
Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu Glu Thr
        115                 120                 125
Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser Ser Pro Ile
    130                 135                 140
Glu Asn Asp Ser Ser Pro
145                 150

<210> 1525
<211> 137
<212> PRT
<213> Homo sapiens

<400> 1525
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
 1               5                  10                  15
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            20                  25                  30
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        35                  40                  45
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    50                  55                  60
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
65                  70                  75                  80
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                85                  90                  95
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            100                 105                 110
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        115                 120                 125
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    130                 135

<210> 1526
<211> 150
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(150)
<223> Xaa = Any Amino Acid

<400> 1526
Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro Tyr Ile Asn
 1               5                  10                  15
Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser
            20                  25                  30
Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile Leu Ser
        35                  40                  45
Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile Ala Gly Ile
    50                  55                  60
Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys Ser Asn Ile
65                  70                  75                  80
Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile Glu Ile Lys
                85                  90                  95
Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn Glu
            100                 105                 110
Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu Glu Thr
        115                 120                 125
Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser Ser Xaa Ile
    130                 135                 140
Glu Asn Asp Ser Ser Pro
145                 150

<210> 1527
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1527
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Leu Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1528
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1528
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Thr Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1529
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1529
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1530
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1530
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Leu Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1531
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1531
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Leu Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1532
<211> 44
<212> PRT
<213> Homo sapiens

<400> 1532
Lys Ile Ser His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala
 1               5                  10                  15
His Thr Pro Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser
            20                  25                  30
Glu Lys Asn Ser Pro Ser Thr Gln Tyr Cys Tyr Ser
        35                  40

<210> 1533
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1533
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1534
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1534
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Leu Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1535
<211> 297
<212> PRT
<213> Homo sapiens

<400> 1535
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro
 1               5                  10                  15
Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg
            20                  25                  30
Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu
        35                  40                  45
Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile
    50                  55                  60
Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile
65                  70                  75                  80
Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile
                85                  90                  95
Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu
            100                 105                 110
Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile
        115                 120                 125
Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser
    130                 135                 140
His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro
145                 150                 155                 160
Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn
                165                 170                 175
Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly
            180                 185                 190
Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile
        195                 200                 205
Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys
    210                 215                 220
Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile
225                 230                 235                 240
Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro
                245                 250                 255
Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu
            260                 265                 270
Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser
        275                 280                 285
Ser Pro Ile Glu Asn Asp Ser Ser Pro
    290                 295

<210> 1536
<211> 365
<212> PRT
<213> Homo sapiens

<400> 1536
Met Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala
 1               5                  10                  15
Ile Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp
            20                  25                  30
Ser Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile
        35                  40                  45
Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln
    50                  55                  60
Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu
65                  70                  75                  80
Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg
                85                  90                  95
Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val
            100                 105                 110
Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala
        115                 120                 125
Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu
    130                 135                 140
Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg
145                 150                 155                 160
Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg
                165                 170                 175
Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala
            180                 185                 190
Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn
        195                 200                 205
Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys
    210                 215                 220
Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln
225                 230                 235                 240
Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp
                245                 250                 255
Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val
            260                 265                 270
Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp
        275                 280                 285
Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly
    290                 295                 300
Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys
305                 310                 315                 320
Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln
                325                 330                 335
Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys
            340                 345                 350
Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys
        355                 360                 365

<210> 1537
<211> 365
<212> PRT
<213> Homo sapiens

<400> 1537
Met Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala
 1               5                  10                  15
Ile Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp
            20                  25                  30
Ser Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile
        35                  40                  45
Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln
    50                  55                  60
Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu
65                  70                  75                  80
Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg
                85                  90                  95
Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val
            100                 105                 110
Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala
        115                 120                 125
Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu
    130                 135                 140
Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg
145                 150                 155                 160
Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg
                165                 170                 175
Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala
            180                 185                 190
Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn
        195                 200                 205
Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys
    210                 215                 220
Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln
225                 230                 235                 240
Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp
                245                 250                 255
Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val
            260                 265                 270
Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp
        275                 280                 285
Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly
    290                 295                 300
Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys
305                 310                 315                 320
Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln
                325                 330                 335
Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys
            340                 345                 350
Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys
        355                 360                 365

<210> 1538
<211> 365
<212> PRT
<213> Homo sapiens

<400> 1538
Met Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala
 1               5                  10                  15
Ile Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp
            20                  25                  30
Ser Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile
        35                  40                  45
Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln
    50                  55                  60
Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu
65                  70                  75                  80
Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg
                85                  90                  95
Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val
            100                 105                 110
Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala
        115                 120                 125
Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu
    130                 135                 140
Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg
145                 150                 155                 160
Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg
                165                 170                 175
Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala
            180                 185                 190
Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn
        195                 200                 205
Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys
    210                 215                 220
Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln
225                 230                 235                 240
Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp
                245                 250                 255
Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val
            260                 265                 270
Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp
        275                 280                 285
Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly
    290                 295                 300
Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys
305                 310                 315                 320
Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln
                325                 330                 335
Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys
            340                 345                 350
Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys
        355                 360                 365

<210> 1539
<211> 365
<212> PRT
<213> Homo sapiens

<400> 1539
Met Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala
 1               5                  10                  15
Ile Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp
            20                  25                  30
Ser Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile
        35                  40                  45
Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln
    50                  55                  60
Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu
65                  70                  75                  80
Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg
                85                  90                  95
Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val
            100                 105                 110
Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala
        115                 120                 125
Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu
    130                 135                 140
Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg
145                 150                 155                 160
Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg
                165                 170                 175
Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala
            180                 185                 190
Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn
        195                 200                 205
Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys
    210                 215                 220
Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln
225                 230                 235                 240
Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp
                245                 250                 255
Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val
            260                 265                 270
Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp
        275                 280                 285
Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly
    290                 295                 300
Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys
305                 310                 315                 320
Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln
                325                 330                 335
Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys
            340                 345                 350
Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys
        355                 360                 365

<210> 1540
<211> 365
<212> PRT
<213> Homo sapiens

<400> 1540
Met Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala
 1               5                  10                  15
Ile Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp
            20                  25                  30
Ser Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile
        35                  40                  45
Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln
    50                  55                  60
Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu
65                  70                  75                  80
Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg
                85                  90                  95
Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val
            100                 105                 110
Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala
        115                 120                 125
Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu
    130                 135                 140
Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg
145                 150                 155                 160
Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg
                165                 170                 175
Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala
            180                 185                 190
Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn
        195                 200                 205
Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys
    210                 215                 220
Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln
225                 230                 235                 240
Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp
                245                 250                 255
Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val
            260                 265                 270
Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp
        275                 280                 285
Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly
    290                 295                 300
Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys
305                 310                 315                 320
Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln
                325                 330                 335
Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys
            340                 345                 350
Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys
        355                 360                 365

<210> 1541
<211> 360
<212> PRT
<213> Homo sapiens

<400> 1541
Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly
 1               5                  10                  15
Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln
            20                  25                  30
Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala
        35                  40                  45
Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu
    50                  55                  60
Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp
65                  70                  75                  80
Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val
                85                  90                  95
Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser
            100                 105                 110
Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala
        115                 120                 125
Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu
    130                 135                 140
Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu
145                 150                 155                 160
Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro
                165                 170                 175
Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu
            180                 185                 190
Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr
        195                 200                 205
Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser
    210                 215                 220
Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp
225                 230                 235                 240
Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile
                245                 250                 255
Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr
            260                 265                 270
Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys
        275                 280                 285
Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly
    290                 295                 300
Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys
305                 310                 315                 320
Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser
                325                 330                 335
Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser
            340                 345                 350
Arg Asp Leu Asp Leu Ser Asp Cys
        355                 360

<210> 1542
<211> 360
<212> PRT
<213> Homo sapiens

<400> 1542
Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly
 1               5                  10                  15
Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln
            20                  25                  30
Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala
        35                  40                  45
Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu
    50                  55                  60
Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp
65                  70                  75                  80
Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val
                85                  90                  95
Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser
            100                 105                 110
Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala
        115                 120                 125
Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu
    130                 135                 140
Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu
145                 150                 155                 160
Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro
                165                 170                 175
Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu
            180                 185                 190
Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr
        195                 200                 205
Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser
    210                 215                 220
Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp
225                 230                 235                 240
Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile
                245                 250                 255
Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr
            260                 265                 270
Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys
        275                 280                 285
Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly
    290                 295                 300
Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys
305                 310                 315                 320
Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser
                325                 330                 335
Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser
            340                 345                 350
Arg Asp Leu Asp Leu Ser Asp Cys
        355                 360

<210> 1543
<211> 360
<212> PRT
<213> Homo sapiens

<400> 1543
Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly
 1               5                  10                  15
Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln
            20                  25                  30
Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala
        35                  40                  45
Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu
    50                  55                  60
Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp
65                  70                  75                  80
Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val
                85                  90                  95
Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser
            100                 105                 110
Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala
        115                 120                 125
Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu
    130                 135                 140
Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu
145                 150                 155                 160
Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro
                165                 170                 175
Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu
            180                 185                 190
Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr
        195                 200                 205
Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser
    210                 215                 220
Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp
225                 230                 235                 240
Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile
                245                 250                 255
Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr
            260                 265                 270
Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys
        275                 280                 285
Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly
    290                 295                 300
Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys
305                 310                 315                 320
Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser
                325                 330                 335
Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser
            340                 345                 350
Arg Asp Leu Asp Leu Ser Asp Cys
        355                 360

<210> 1544
<211> 360
<212> PRT
<213> Homo sapiens

<400> 1544
Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly
 1               5                  10                  15
Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln
            20                  25                  30
Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala
        35                  40                  45
Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu
    50                  55                  60
Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp
65                  70                  75                  80
Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val
                85                  90                  95
Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser
            100                 105                 110
Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala
        115                 120                 125
Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu
    130                 135                 140
Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu
145                 150                 155                 160
Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro
                165                 170                 175
Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu
            180                 185                 190
Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr
        195                 200                 205
Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser
    210                 215                 220
Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp
225                 230                 235                 240
Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile
                245                 250                 255
Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr
            260                 265                 270
Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys
        275                 280                 285
Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly
    290                 295                 300
Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys
305                 310                 315                 320
Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser
                325                 330                 335
Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser
            340                 345                 350
Arg Asp Leu Asp Leu Ser Asp Cys
        355                 360

<210> 1545
<211> 792
<212> PRT
<213> Homo sapiens

<400> 1545
Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp
 1               5                  10                  15
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
            20                  25                  30
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
        35                  40                  45
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
    50                  55                  60
Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg
65                  70                  75                  80
Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp
                85                  90                  95
Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Lys His
            100                 105                 110
Ser Pro Met Val Ala Lys Ser Thr Leu Asp Ile Val Leu Ala Asn Lys
        115                 120                 125
Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn
    130                 135                 140
Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn
145                 150                 155                 160
Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val
                165                 170                 175
Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu
            180                 185                 190
Leu Ser Glu Arg Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala
        195                 200                 205
Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys
    210                 215                 220
Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu
225                 230                 235                 240
Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg
                245                 250                 255
Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu
            260                 265                 270
Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln
        275                 280                 285
Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp
    290                 295                 300
His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys
305                 310                 315                 320
Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp
                325                 330                 335
Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys
            340                 345                 350
Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu
        355                 360                 365
Lys Leu Tyr Ala Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val
    370                 375                 380
Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr
385                 390                 395                 400
Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn
                405                 410                 415
Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile
            420                 425                 430
Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser
        435                 440                 445
Leu Ala Leu Asn Met Tyr Val Thr Ser Glu His Thr Tyr Asp Phe Lys
    450                 455                 460
Lys Leu Ala Glu Val Thr Lys Val Val Val Arg Asn Leu Asn Lys Ile
465                 470                 475                 480
Ile Asp Ile Asn Tyr Tyr Pro Val Pro Glu Ala Cys Leu Ser Asn Lys
                485                 490                 495
Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Ala Asp Ala Phe
            500                 505                 510
Ile Leu Met Arg Tyr Pro Phe Glu Ser Ala Glu Ala Gln Leu Leu Asn
        515                 520                 525
Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys
    530                 535                 540
Asp Leu Ala Lys Glu Gln Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro
545                 550                 555                 560
Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Thr Pro Thr
                565                 570                 575
Asp Leu Trp Asp Trp Lys Val Leu Lys Glu Lys Ile Ala Lys Tyr Gly
            580                 585                 590
Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala
        595                 600                 605
Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile
    610                 615                 620
Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His
625                 630                 635                 640
Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp His Glu Glu Met Lys
                645                 650                 655
Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile
            660                 665                 670
Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln
        675                 680                 685
Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln
    690                 695                 700
Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu
705                 710                 715                 720
Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met
                725                 730                 735
Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu
            740                 745                 750
Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Val Ser Lys Glu Glu Glu
        755                 760                 765
Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg
    770                 775                 780
Asp Glu Cys Leu Met Cys Gly Ser
785                 790

<210> 1546
<211> 792
<212> PRT
<213> Homo sapiens

<400> 1546
Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp
 1               5                  10                  15
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
            20                  25                  30
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
        35                  40                  45
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
    50                  55                  60
Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg
65                  70                  75                  80
Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp
                85                  90                  95
Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Lys His
            100                 105                 110
Ser Pro Met Val Ala Lys Ser Thr Leu Asp Ile Val Leu Ala Asn Lys
        115                 120                 125
Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn
    130                 135                 140
Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn
145                 150                 155                 160
Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val
                165                 170                 175
Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu
            180                 185                 190
Leu Ser Glu Arg Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala
        195                 200                 205
Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys
    210                 215                 220
Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu
225                 230                 235                 240
Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg
                245                 250                 255
Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu
            260                 265                 270
Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln
        275                 280                 285
Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp
    290                 295                 300
His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys
305                 310                 315                 320
Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp
                325                 330                 335
Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys
            340                 345                 350
Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu
        355                 360                 365
Lys Leu Tyr Ala Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val
    370                 375                 380
Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr
385                 390                 395                 400
Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn
                405                 410                 415
Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile
            420                 425                 430
Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser
        435                 440                 445
Leu Ala Leu Asn Met Tyr Val Thr Ser Glu His Thr Tyr Asp Phe Lys
    450                 455                 460
Lys Leu Ala Glu Val Thr Lys Val Val Val Arg Asn Leu Asn Lys Ile
465                 470                 475                 480
Ile Asp Ile Asn Tyr Tyr Pro Val Pro Glu Ala Cys Leu Ser Asn Lys
                485                 490                 495
Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Ala Asp Ala Phe
            500                 505                 510
Ile Leu Met Arg Tyr Pro Phe Glu Ser Ala Glu Ala Gln Leu Leu Asn
        515                 520                 525
Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys
    530                 535                 540
Asp Leu Ala Lys Glu Gln Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro
545                 550                 555                 560
Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Thr Pro Thr
                565                 570                 575
Asp Leu Trp Asp Trp Lys Val Leu Lys Glu Lys Ile Ala Lys Tyr Gly
            580                 585                 590
Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala
        595                 600                 605
Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile
    610                 615                 620
Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His
625                 630                 635                 640
Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp His Glu Glu Met Lys
                645                 650                 655
Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile
            660                 665                 670
Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln
        675                 680                 685
Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln
    690                 695                 700
Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu
705                 710                 715                 720
Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met
                725                 730                 735
Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu
            740                 745                 750
Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Val Ser Lys Glu Glu Glu
        755                 760                 765
Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg
    770                 775                 780
Asp Glu Cys Leu Met Cys Gly Ser
785                 790

<210> 1547
<211> 792
<212> PRT
<213> Homo sapiens

<400> 1547
Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp
 1               5                  10                  15
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
            20                  25                  30
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
        35                  40                  45
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
    50                  55                  60
Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg
65                  70                  75                  80
Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp
                85                  90                  95
Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Lys His
            100                 105                 110
Ser Pro Met Val Ala Lys Ser Thr Leu Asp Ile Val Leu Ala Asn Lys
        115                 120                 125
Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn
    130                 135                 140
Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn
145                 150                 155                 160
Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val
                165                 170                 175
Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu
            180                 185                 190
Leu Ser Glu Arg Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala
        195                 200                 205
Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys
    210                 215                 220
Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu
225                 230                 235                 240
Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg
                245                 250                 255
Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu
            260                 265                 270
Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln
        275                 280                 285
Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp
    290                 295                 300
His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys
305                 310                 315                 320
Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp
                325                 330                 335
Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys
            340                 345                 350
Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu
        355                 360                 365
Lys Leu Tyr Ala Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val
    370                 375                 380
Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr
385                 390                 395                 400
Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn
                405                 410                 415
Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile
            420                 425                 430
Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser
        435                 440                 445
Leu Ala Leu Asn Met Tyr Val Thr Ser Glu His Thr Tyr Asp Phe Lys
    450                 455                 460
Lys Leu Ala Glu Val Thr Lys Val Val Val Arg Asn Leu Asn Lys Ile
465                 470                 475                 480
Ile Asp Ile Asn Tyr Tyr Pro Val Pro Glu Ala Cys Leu Ser Asn Lys
                485                 490                 495
Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Ala Asp Ala Phe
            500                 505                 510
Ile Leu Met Arg Tyr Pro Phe Glu Ser Ala Glu Ala Gln Leu Leu Asn
        515                 520                 525
Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys
    530                 535                 540
Asp Leu Ala Lys Glu Gln Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro
545                 550                 555                 560
Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Thr Pro Thr
                565                 570                 575
Asp Leu Trp Asp Trp Lys Val Leu Lys Glu Lys Ile Ala Lys Tyr Gly
            580                 585                 590
Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala
        595                 600                 605
Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile
    610                 615                 620
Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His
625                 630                 635                 640
Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp His Glu Glu Met Lys
                645                 650                 655
Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile
            660                 665                 670
Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln
        675                 680                 685
Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln
    690                 695                 700
Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu
705                 710                 715                 720
Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met
                725                 730                 735
Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu
            740                 745                 750
Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Val Ser Lys Glu Glu Glu
        755                 760                 765
Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg
    770                 775                 780
Asp Glu Cys Leu Met Cys Gly Ser
785                 790

<210> 1548
<211> 792
<212> PRT
<213> Homo sapiens

<400> 1548
Met His Val Ile Lys Gln Asp Gly Arg Gln Glu Arg Val Met Phe Asp
 1               5                  10                  15
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
            20                  25                  30
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
        35                  40                  45
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
    50                  55                  60
Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg
65                  70                  75                  80
Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp
                85                  90                  95
Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Lys His
            100                 105                 110
Ser Pro Met Val Ala Lys Ser Thr Leu Asp Ile Val Leu Ala Asn Lys
        115                 120                 125
Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn
    130                 135                 140
Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn
145                 150                 155                 160
Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val
                165                 170                 175
Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu
            180                 185                 190
Leu Ser Glu Arg Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala
        195                 200                 205
Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys
    210                 215                 220
Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu
225                 230                 235                 240
Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg
                245                 250                 255
Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu
            260                 265                 270
Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln
        275                 280                 285
Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp
    290                 295                 300
His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys
305                 310                 315                 320
Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp
                325                 330                 335
Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys
            340                 345                 350
Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu
        355                 360                 365
Lys Leu Tyr Ala Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val
    370                 375                 380
Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr
385                 390                 395                 400
Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn
                405                 410                 415
Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile
            420                 425                 430
Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser
        435                 440                 445
Leu Ala Leu Asn Met Tyr Val Thr Ser Glu His Thr Tyr Asp Phe Lys
    450                 455                 460
Lys Leu Ala Glu Val Thr Lys Val Val Val Arg Asn Leu Asn Lys Ile
465                 470                 475                 480
Ile Asp Ile Asn Tyr Tyr Pro Val Pro Glu Ala Cys Leu Ser Asn Lys
                485                 490                 495
Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Ala Asp Ala Phe
            500                 505                 510
Ile Leu Met Arg Tyr Pro Phe Glu Ser Ala Glu Ala Gln Leu Leu Asn
        515                 520                 525
Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys
    530                 535                 540
Asp Leu Ala Lys Glu Gln Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro
545                 550                 555                 560
Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Thr Pro Thr
                565                 570                 575
Asp Leu Trp Asp Trp Lys Val Leu Lys Glu Lys Ile Ala Lys Tyr Gly
            580                 585                 590
Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala
        595                 600                 605
Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile
    610                 615                 620
Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His
625                 630                 635                 640
Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp His Glu Glu Met Lys
                645                 650                 655
Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile
            660                 665                 670
Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln
        675                 680                 685
Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln
    690                 695                 700
Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu
705                 710                 715                 720
Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met
                725                 730                 735
Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu
            740                 745                 750
Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Val Ser Lys Glu Glu Glu
        755                 760                 765
Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg
    770                 775                 780
Asp Glu Cys Leu Met Cys Gly Ser
785                 790

<210> 1549
<211> 124
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(124)
<223> Xaa = Any Amino Acid

<400> 1549
Ser Arg Ser Pro Val Leu Asp Pro Ser Glu Pro Gln Pro Leu Ala Ala
 1               5                  10                  15
Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp
            20                  25                  30
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
        35                  40                  45
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
    50                  55                  60
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
65                  70                  75                  80
Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg
                85                  90                  95
Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp
            100                 105                 110
Val Met Glu Asp Leu Tyr Xaa Leu His Lys Ser Thr
        115                 120

<210> 1550
<211> 69
<212> PRT
<213> Homo sapiens

<400> 1550
Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp
 1               5                  10                  15
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
            20                  25                  30
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
        35                  40                  45
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
    50                  55                  60
Ala Thr Leu Thr Thr
65

<210> 1551
<211> 808
<212> PRT
<213> Homo sapiens

<400> 1551
Ser Gly Ser Pro Val Leu Asp Pro Ser Glu Pro Gln Pro Leu Ala Ala
 1               5                  10                  15
Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp
            20                  25                  30
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
        35                  40                  45
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
    50                  55                  60
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
65                  70                  75                  80
Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg
                85                  90                  95
Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp
            100                 105                 110
Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Lys His
        115                 120                 125
Ser Pro Met Val Ala Lys Ser Thr Leu Asp Ile Val Leu Ala Asn Lys
    130                 135                 140
Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn
145                 150                 155                 160
Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn
                165                 170                 175
Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val
            180                 185                 190
Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu
        195                 200                 205
Leu Ser Glu Arg Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala
    210                 215                 220
Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys
225                 230                 235                 240
Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu
                245                 250                 255
Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg
            260                 265                 270
Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu
        275                 280                 285
Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln
    290                 295                 300
Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp
305                 310                 315                 320
His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys
                325                 330                 335
Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp
            340                 345                 350
Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys
        355                 360                 365
Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu
    370                 375                 380
Lys Leu Tyr Ala Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val
385                 390                 395                 400
Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr
                405                 410                 415
Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn
            420                 425                 430
Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile
        435                 440                 445
Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser
    450                 455                 460
Leu Ala Leu Asn Met Tyr Val Thr Ser Glu His Thr Tyr Asp Phe Lys
465                 470                 475                 480
Lys Leu Ala Glu Val Thr Lys Val Val Val Arg Asn Leu Asn Lys Ile
                485                 490                 495
Ile Asp Ile Asn Tyr Tyr Pro Val Pro Glu Ala Cys Leu Ser Asn Lys
            500                 505                 510
Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Ala Asp Ala Phe
        515                 520                 525
Ile Leu Met Arg Tyr Pro Phe Glu Ser Ala Glu Ala Gln Leu Leu Asn
    530                 535                 540
Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys
545                 550                 555                 560
Asp Leu Ala Lys Glu Gln Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro
                565                 570                 575
Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Thr Pro Thr
            580                 585                 590
Asp Leu Trp Asp Trp Lys Val Leu Lys Glu Lys Ile Ala Lys Tyr Gly
        595                 600                 605
Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala
    610                 615                 620
Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile
625                 630                 635                 640
Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His
                645                 650                 655
Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp His Glu Glu Met Lys
            660                 665                 670
Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile
        675                 680                 685
Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln
    690                 695                 700
Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln
705                 710                 715                 720
Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu
                725                 730                 735
Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met
            740                 745                 750
Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu
        755                 760                 765
Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Val Ser Lys Glu Glu Glu
    770                 775                 780
Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg
785                 790                 795                 800
Asp Glu Cys Leu Met Cys Gly Ser
                805

<210> 1552
<211> 792
<212> PRT
<213> Homo sapiens

<400> 1552
Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp
 1               5                  10                  15
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
            20                  25                  30
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
        35                  40                  45
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
    50                  55                  60
Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg
65                  70                  75                  80
Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp
                85                  90                  95
Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Arg His
            100                 105                 110
Ser Pro Met Val Ala Ser Ser Thr Leu Asp Ile Val Met Ala Asn Lys
        115                 120                 125
Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn
    130                 135                 140
Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn
145                 150                 155                 160
Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val
                165                 170                 175
Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu
            180                 185                 190
Leu Ser Glu Lys Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala
        195                 200                 205
Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys
    210                 215                 220
Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu
225                 230                 235                 240
Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg
                245                 250                 255
Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu
            260                 265                 270
Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln
        275                 280                 285
Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp
    290                 295                 300
His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys
305                 310                 315                 320
Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp
                325                 330                 335
Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys
            340                 345                 350
Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu
        355                 360                 365
Lys Leu Tyr Glu Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val
    370                 375                 380
Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr
385                 390                 395                 400
Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn
                405                 410                 415
Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile
            420                 425                 430
Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser
        435                 440                 445
Leu Ala Leu Asn Met Tyr Val Thr Pro Glu His Thr Tyr Asp Phe Glu
    450                 455                 460
Lys Leu Ala Glu Val Thr Lys Val Ile Val Arg Asn Leu Asn Lys Ile
465                 470                 475                 480
Ile Asp Ile Asn Tyr Tyr Pro Ile Pro Glu Ala His Leu Ser Asn Lys
                485                 490                 495
Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Glu Asp Ala Phe
            500                 505                 510
Ile Leu Met Arg Tyr Pro Phe Glu Ser Pro Glu Ala Gln Leu Leu Asn
        515                 520                 525
Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys
    530                 535                 540
Glu Leu Ala Lys Glu Tyr Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro
545                 550                 555                 560
Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Ala Pro Thr
                565                 570                 575
Asp Leu Trp Asp Trp Lys Pro Leu Lys Glu Lys Ile Ala Lys Tyr Gly
            580                 585                 590
Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala
        595                 600                 605
Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile
    610                 615                 620
Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His
625                 630                 635                 640
Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp Asn Glu Glu Met Lys
                645                 650                 655
Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile
            660                 665                 670
Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln
        675                 680                 685
Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln
    690                 695                 700
Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu
705                 710                 715                 720
Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met
                725                 730                 735
Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu
            740                 745                 750
Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Ala Leu Lys Glu Glu Glu
        755                 760                 765
Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg
    770                 775                 780
Glu Glu Cys Leu Met Cys Gly Ser
785                 790

<210> 1553
<211> 792
<212> PRT
<213> Homo sapiens

<400> 1553
Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp
 1               5                  10                  15
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
            20                  25                  30
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
        35                  40                  45
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
    50                  55                  60
Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg
65                  70                  75                  80
Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp
                85                  90                  95
Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Lys His
            100                 105                 110
Ser Pro Met Val Ala Lys Ser Thr Leu Asp Ile Val Leu Ala Asn Lys
        115                 120                 125
Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn
    130                 135                 140
Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn
145                 150                 155                 160
Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val
                165                 170                 175
Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu
            180                 185                 190
Leu Ser Glu Arg Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala
        195                 200                 205
Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys
    210                 215                 220
Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu
225                 230                 235                 240
Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg
                245                 250                 255
Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu
            260                 265                 270
Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln
        275                 280                 285
Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp
    290                 295                 300
His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys
305                 310                 315                 320
Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp
                325                 330                 335
Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys
            340                 345                 350
Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu
        355                 360                 365
Lys Leu Tyr Ala Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val
    370                 375                 380
Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr
385                 390                 395                 400
Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn
                405                 410                 415
Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile
            420                 425                 430
Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser
        435                 440                 445
Leu Ala Leu Asn Met Tyr Val Thr Ser Glu His Thr Tyr Asp Phe Lys
    450                 455                 460
Lys Leu Ala Glu Val Thr Lys Val Val Val Arg Asn Leu Asn Lys Ile
465                 470                 475                 480
Ile Asp Ile Asn Tyr Tyr Pro Val Pro Glu Ala Cys Leu Ser Asn Lys
                485                 490                 495
Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Ala Asp Ala Phe
            500                 505                 510
Ile Leu Met Arg Tyr Pro Phe Glu Ser Ala Glu Ala Gln Leu Leu Asn
        515                 520                 525
Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys
    530                 535                 540
Asp Leu Ala Lys Glu Gln Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro
545                 550                 555                 560
Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Thr Pro Thr
                565                 570                 575
Asp Leu Trp Asp Trp Lys Val Leu Lys Glu Lys Ile Ala Lys Tyr Gly
            580                 585                 590
Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala
        595                 600                 605
Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile
    610                 615                 620
Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His
625                 630                 635                 640
Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp His Glu Glu Met Lys
                645                 650                 655
Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile
            660                 665                 670
Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln
        675                 680                 685
Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln
    690                 695                 700
Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu
705                 710                 715                 720
Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met
                725                 730                 735
Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu
            740                 745                 750
Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Val Ser Lys Glu Glu Glu
        755                 760                 765
Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg
    770                 775                 780
Asp Glu Cys Leu Met Cys Gly Ser
785                 790

<210> 1554
<211> 792
<212> PRT
<213> Homo sapiens

<400> 1554
Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp
 1               5                  10                  15
Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp
            20                  25                  30
Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr
        35                  40                  45
Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala
    50                  55                  60
Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg
65                  70                  75                  80
Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp
                85                  90                  95
Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Lys His
            100                 105                 110
Ser Pro Met Val Ala Lys Ser Thr Leu Asp Ile Val Leu Ala Asn Lys
        115                 120                 125
Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn
    130                 135                 140
Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn
145                 150                 155                 160
Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val
                165                 170                 175
Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu
            180                 185                 190
Leu Ser Glu Arg Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala
        195                 200                 205
Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys
    210                 215                 220
Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu
225                 230                 235                 240
Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg
                245                 250                 255
Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu
            260                 265                 270
Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln
        275                 280                 285
Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp
    290                 295                 300
His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys
305                 310                 315                 320
Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp
                325                 330                 335
Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys
            340                 345                 350
Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu
        355                 360                 365
Lys Leu Tyr Ala Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val
    370                 375                 380
Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr
385                 390                 395                 400
Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn
                405                 410                 415
Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile
            420                 425                 430
Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser
        435                 440                 445
Leu Ala Leu Asn Met Tyr Val Thr Ser Glu His Thr Tyr Asp Phe Lys
    450                 455                 460
Lys Leu Ala Glu Val Thr Lys Val Val Val Arg Asn Leu Asn Lys Ile
465                 470                 475                 480
Ile Asp Ile Asn Tyr Tyr Pro Val Pro Glu Ala Cys Leu Ser Asn Lys
                485                 490                 495
Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Ala Asp Ala Phe
            500                 505                 510
Ile Leu Met Arg Tyr Pro Phe Glu Ser Ala Glu Ala Gln Leu Leu Asn
        515                 520                 525
Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys
    530                 535                 540
Asp Leu Ala Lys Glu Gln Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro
545                 550                 555                 560
Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Thr Pro Thr
                565                 570                 575
Asp Leu Trp Asp Trp Lys Val Leu Lys Glu Lys Ile Ala Lys Tyr Gly
            580                 585                 590
Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala
        595                 600                 605
Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile
    610                 615                 620
Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His
625                 630                 635                 640
Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp His Glu Glu Met Lys
                645                 650                 655
Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile
            660                 665                 670
Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln
        675                 680                 685
Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln
    690                 695                 700
Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu
705                 710                 715                 720
Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met
                725                 730                 735
Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu
            740                 745                 750
Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Val Ser Lys Glu Glu Glu
        755                 760                 765
Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg
    770                 775                 780
Asp Glu Cys Leu Met Cys Gly Ser
785                 790

<210> 1555
<211> 171
<212> PRT
<213> Homo sapiens

<400> 1555
Phe Val Val Glu Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro
 1               5                  10                  15
Leu Val Leu Lys Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu
            20                  25                  30
Val Lys Leu Gln Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe
        35                  40                  45
Asp Lys Asp Val Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe
    50                  55                  60
Asn Ile Leu Gly Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr
65                  70                  75                  80
Asn Gly Ser Leu Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln
                85                  90                  95
Lys Asn Ala Gly Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu
            100                 105                 110
Glu Leu His Ser Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu
        115                 120                 125
Val Ile Asp Leu Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn
    130                 135                 140
Val Ser Gln Leu Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met
145                 150                 155                 160
Leu Val Ala Glu Pro Arg Asn Leu Ser Phe Phe
                165                 170

<210> 1556
<211> 530
<212> PRT
<213> Homo sapiens

<400> 1556
Met Ala Thr Gly Gly Gly Pro Phe Glu Asp Gly Met Asn Asp Gln Asp
 1               5                  10                  15
Leu Pro Asn Trp Ser Asn Glu Asn Val Asp Asp Arg Leu Asn Asn Met
            20                  25                  30
Asp Trp Gly Ala Gln Gln Lys Lys Ala Asn Arg Ser Ser Glu Lys Asn
        35                  40                  45
Lys Lys Lys Phe Gly Val Glu Ser Asp Lys Arg Val Thr Asn Asp Ile
    50                  55                  60
Ser Pro Glu Ser Ser Pro Gly Val Gly Arg Arg Arg Thr Lys Thr Pro
65                  70                  75                  80
His Thr Phe Pro His Ser Arg Tyr Met Ser Gln Met Ser Val Pro Glu
                85                  90                  95
Gln Ala Glu Leu Glu Lys Leu Lys Gln Arg Ile Asn Phe Ser Asp Leu
            100                 105                 110
Asp Gln Arg Ser Ile Gly Ser Asp Ser Gln Gly Arg Ala Thr Ala Ala
        115                 120                 125
Asn Asn Lys Arg Gln Leu Ser Glu Asn Arg Lys Pro Phe Asn Phe Leu
    130                 135                 140
Pro Met Gln Ile Asn Thr Asn Lys Ser Lys Asp Ala Ser Thr Ser Pro
145                 150                 155                 160
Pro Asn Arg Glu Thr Ile Gly Ser Ala Gln Cys Lys Glu Leu Phe Ala
                165                 170                 175
Ser Ala Leu Ser Asn Asp Leu Leu Gln Asn Cys Gln Val Ser Glu Glu
            180                 185                 190
Asp Gly Arg Gly Glu Pro Ala Met Glu Ser Ser Gln Ile Val Ser Arg
        195                 200                 205
Leu Val Gln Ile Arg Asp Tyr Ile Thr Lys Ala Ser Ser Met Arg Glu
    210                 215                 220
Asp Leu Val Glu Lys Asn Glu Arg Ser Ala Asn Val Glu Arg Leu Thr
225                 230                 235                 240
His Leu Ile Asp His Leu Lys Glu Gln Glu Lys Ser Tyr Met Lys Phe
                245                 250                 255
Leu Lys Lys Ile Leu Ala Arg Glu Asn Glu Glu Glu Asp Val Arg Thr
            260                 265                 270
Ile Asp Ser Ala Val Gly Ser Gly Ser Val Ala Glu Ser Thr Ser Leu
        275                 280                 285
Asn Ile Asp Val Gln Ser Glu Ala Ser Asp Thr Thr Ala Arg Asp Pro
    290                 295                 300
Gln Gln Glu Pro Met Glu Glu Ile Glu Asn Leu Lys Lys Gln His Asp
305                 310                 315                 320
Leu Leu Lys Arg Met Leu Gln Gln Gln Glu Gln Leu Arg Ala Leu Gln
                325                 330                 335
Gly Arg Gln Ala Ala Leu Leu Ala Leu Gln His Lys Ala Glu Gln Ala
            340                 345                 350
Ile Ala Val Met Asp Asp Ser Val Val Ala Glu Thr Ala Gly Ser Leu
        355                 360                 365
Ser Gly Val Ser Ile Thr Ser Glu Leu Asn Glu Glu Leu Asn Asp Leu
    370                 375                 380
Ile Gln Arg Phe His Asn Gln Leu Arg Asp Ser Gln Pro Pro Ala Val
385                 390                 395                 400
Pro Asp Asn Arg Arg Gln Ala Glu Ser Leu Ser Leu Thr Arg Glu Val
                405                 410                 415
Ser Gln Ser Arg Lys Pro Ser Ala Ser Glu Arg Leu Pro Asp Glu Lys
            420                 425                 430
Val Glu Leu Phe Ser Lys Met Arg Val Leu Gln Glu Lys Lys Gln Lys
        435                 440                 445
Met Asp Lys Leu Leu Gly Glu Leu His Thr Leu Arg Asp Gln His Leu
    450                 455                 460
Asn Asn Ser Ser Ser Ser Pro Gln Arg Ser Val Asp Gln Arg Ser Thr
465                 470                 475                 480
Ser Ala Pro Ser Ala Ser Val Gly Leu Ala Pro Val Val Asn Gly Glu
                485                 490                 495
Ser Asn Ser Leu Thr Ser Ser Val Pro Tyr Pro Thr Ala Ser Leu Val
            500                 505                 510
Ser Gln Asn Glu Ser Glu Asn Glu Gly His Leu Asn Pro Ser Glu Lys
        515                 520                 525
Leu Gln
    530

<210> 1557
<211> 2024
<212> PRT
<213> Homo sapiens

<400> 1557
Met Ala Thr Gly Gly Gly Pro Phe Glu Asp Gly Met Asn Asp Gln Asp
 1               5                  10                  15
Leu Pro Asn Trp Ser Asn Glu Asn Val Asp Asp Arg Leu Asn Asn Met
            20                  25                  30
Asp Trp Gly Ala Gln Gln Lys Lys Ala Asn Arg Ser Ser Glu Lys Asn
        35                  40                  45
Lys Lys Lys Phe Gly Val Glu Ser Asp Lys Arg Val Thr Asn Asp Ile
    50                  55                  60
Ser Pro Glu Ser Ser Pro Gly Val Gly Arg Arg Arg Thr Lys Thr Pro
65                  70                  75                  80
His Thr Phe Pro His Ser Arg Tyr Met Ser Gln Met Ser Val Pro Glu
                85                  90                  95
Gln Ala Glu Leu Glu Lys Leu Lys Gln Arg Ile Asn Phe Ser Asp Leu
            100                 105                 110
Asp Gln Arg Ser Ile Gly Ser Asp Ser Gln Gly Arg Ala Thr Ala Ala
        115                 120                 125
Asn Asn Lys Arg Gln Leu Ser Glu Asn Arg Lys Pro Phe Asn Phe Leu
    130                 135                 140
Pro Met Gln Ile Asn Thr Asn Lys Ser Lys Asp Ala Ser Thr Ser Pro
145                 150                 155                 160
Pro Asn Arg Glu Thr Ile Gly Ser Ala Gln Cys Lys Glu Leu Phe Ala
                165                 170                 175
Ser Ala Leu Ser Asn Asp Leu Leu Gln Asn Cys Gln Val Ser Glu Glu
            180                 185                 190
Asp Gly Arg Gly Glu Pro Ala Met Glu Ser Ser Gln Ile Val Ser Arg
        195                 200                 205
Leu Val Gln Ile Arg Asp Tyr Ile Thr Lys Ala Ser Ser Met Arg Glu
    210                 215                 220
Asp Leu Val Glu Lys Asn Glu Arg Ser Ala Asn Val Glu Arg Leu Thr
225                 230                 235                 240
His Leu Ile Asp His Leu Lys Glu Gln Glu Lys Ser Tyr Met Lys Phe
                245                 250                 255
Leu Lys Lys Ile Leu Ala Arg Asp Pro Gln Gln Glu Pro Met Glu Glu
            260                 265                 270
Ile Glu Asn Leu Lys Lys Gln His Asp Leu Leu Lys Arg Met Leu Gln
        275                 280                 285
Gln Gln Glu Gln Leu Arg Gly Ala Leu Gln Gly Arg Gln Ala Ala Leu
    290                 295                 300
Leu Ala Leu Gln His Lys Ala Asp Glu Ala Ile Ala Val Met Asp Asp
305                 310                 315                 320
Ser Val Val Ala Glu Thr Ala Gly Ser Leu Ser Gly Val Ser Ile Thr
                325                 330                 335
Ser Glu Leu Asn Glu Glu Leu Asn Asp Leu Ile Gln Arg Phe His Asn
            340                 345                 350
Gln Leu Arg Asp Ser Gln Pro Pro Ala Val Pro Asp Asn Arg Arg Gln
        355                 360                 365
Ala Glu Ser Leu Ser Leu Thr Arg Glu Val Ser Gln Ser Arg Lys Pro
    370                 375                 380
Ser Ala Ser Glu Arg Leu Pro Asp Glu Lys Val Glu Leu Phe Ser Lys
385                 390                 395                 400
Met Arg Val Leu Gln Glu Lys Lys Gln Lys Met Asp Lys Leu Leu Gly
                405                 410                 415
Glu Leu His Thr Leu Arg Asp Gln His Leu Asn Asn Ser Ser Ser Ser
            420                 425                 430
Pro Gln Arg Ser Val Asp Gln Arg Ser Thr Ser Ala Pro Ser Ala Cys
        435                 440                 445
Leu Gly Leu Ala Pro Val Val Asn Gly Glu Ser Asn Ser Leu Thr Ser
    450                 455                 460
Ser Val Pro Tyr Pro Thr Ala Ser Leu Val Ser Gln Asn Glu Ser Glu
465                 470                 475                 480
Asn Glu Gly His Leu Asn Pro Ser Glu Lys Leu Gln Lys Leu Asn Glu
                485                 490                 495
Val Arg Lys Arg Leu Asn Glu Leu Arg Glu Leu Val His Tyr Tyr Glu
            500                 505                 510
Gln Thr Ser Asp Met Met Thr Asp Ala Val Asn Glu Asn Arg Lys Asp
        515                 520                 525
Glu Glu Thr Glu Glu Ser Glu Tyr Asp Ser Glu His Glu Asn Ser Glu
    530                 535                 540
Pro Val Thr Asn Ile Arg Asn Pro Gln Val Ala Ser Thr Trp Asn Glu
545                 550                 555                 560
Val Asn Ser His Ser Asn Ala Gln Cys Val Ser Asn Asn Arg Asp Gly
                565                 570                 575
Arg Thr Val Asn Ser Asn Cys Glu Ile Asn Asn Arg Ser Ala Ala Asn
            580                 585                 590
Ile Arg Ala Leu Asn Val Pro Pro Ser Leu Asp Cys Arg Tyr Asn Arg
        595                 600                 605
Glu Gly Glu Gln Glu Ile His Val Ala Gln Gly Glu Asp Asp Glu Glu
    610                 615                 620
Glu Glu Glu Glu Ala Glu Glu Glu Gly Val Ser Gly Ala Ser Leu Ser
625                 630                 635                 640
Ser His Arg Ser Ser Leu Val Asp Glu His Pro Glu Asp Ala Glu Phe
                645                 650                 655
Glu Gln Lys Ile Asn Arg Leu Met Ala Ala Lys Gln Lys Leu Arg Gln
            660                 665                 670
Leu Gln Asp Leu Val Ala Met Val Gln Asp Asp Asp Ala Ala Gln Gly
        675                 680                 685
Val Ile Ser Ala Ser Ala Ser Asn Leu Asp Asp Phe Tyr Pro Ala Glu
    690                 695                 700
Glu Asp Thr Lys Gln Asn Ser Asn Asn Thr Arg Gly Asn Ala Asn Lys
705                 710                 715                 720
Thr Gln Lys Asp Thr Gly Val Asn Glu Lys Ala Arg Glu Lys Phe Tyr
                725                 730                 735
Glu Ala Lys Leu Gln Gln Gln Gln Arg Glu Leu Lys Gln Leu Gln Glu
            740                 745                 750
Glu Arg Lys Lys Leu Ile Asp Ile His Glu Lys Ile Gln Ala Leu Gln
        755                 760                 765
Thr Ala Cys Pro Asp Leu Gln Leu Ser Ala Ala Ser Val Gly Asn Cys
    770                 775                 780
Pro Thr Lys Lys Tyr Met Pro Ala Val Thr Ser Thr Pro Thr Val Asn
785                 790                 795                 800
Gln His Glu Thr Ser Thr Ser Lys Ser Val Phe Glu Pro Glu Asp Ser
                805                 810                 815
Ser Ile Val Asp Asn Glu Leu Trp Ser Glu Met Arg Arg His Glu Met
            820                 825                 830
Leu Arg Glu Glu Leu Arg Gln Arg Arg Lys Gln Leu Glu Ala Leu Met
        835                 840                 845
Ala Glu His Gln Arg Arg Gln Gly Leu Ala Glu Thr Ala Ser Pro Val
    850                 855                 860
Ala Val Ser Leu Arg Ser Asp Gly Ser Glu Asn Leu Cys Thr Pro Gln
865                 870                 875                 880
Gln Ser Arg Thr Glu Lys Thr Met Ala Thr Trp Gly Gly Ser Thr Gln
                885                 890                 895
Cys Ala Leu Asp Glu Glu Gly Asp Glu Asp Gly Tyr Leu Ser Glu Gly
            900                 905                 910
Ile Val Arg Thr Asp Glu Glu Glu Glu Glu Glu Gln Asp Ala Ser Ser
        915                 920                 925
Asn Asp Asn Phe Ser Val Cys Pro Ser Asn Ser Val Asn His Asn Ser
    930                 935                 940
Tyr Asn Arg Lys Glu Thr Lys Asn Thr Trp Lys Asn Asn Cys Pro Phe
945                 950                 955                 960
Ser Ala Asp Glu Asn Tyr Arg Pro Leu Ala Lys Thr Arg Gln Gln Asn
                965                 970                 975
Ile Ser Met Gln Arg Gln Glu Asn Leu Arg Trp Val Ser Glu Leu Ser
            980                 985                 990
Tyr Val Glu Glu Lys Glu Gln Trp Gln Glu Gln Ile Gln Leu Lys Lys
        995                 1000                1005
Gln Leu Asp Phe Ser Val Ser Ile Cys Gln Thr Leu Met Gln Asp Gln
    1010                1015                1020
Gln Thr Leu Ser Cys Leu Leu Gln Thr Leu Leu Thr Gly Pro Tyr Ser
1025                1030                1035                1040
Val Met Pro Ser Asn Val Ala Ser Pro Gln Val His Phe Ile Met His
                1045                1050                1055
Gln Leu Asn Gln Cys Tyr Thr Gln Leu Thr Trp Gln Gln Asn Asn Val
            1060                1065                1070
Gln Arg Leu Lys Gln Met Leu Asn Glu Leu Met Arg Gln Arg Asn Gln
        1075                1080                1085
His Pro Glu Lys Pro Gly Gly Lys Glu Arg Gly Ser Ser Ala Ser His
    1090                1095                1100
Pro Pro Ser Pro Ser Leu Phe Cys Pro Phe Ser Phe Pro Thr Gln Pro
1105                1110                1115                1120
Val Asn Leu Phe Asn Ile Pro Gly Phe Thr Asn Phe Ser Ser Phe Ala
                1125                1130                1135
Pro Gly Met Asn Phe Ser Pro Leu Phe Pro Ser Asn Phe Gly Asp Phe
            1140                1145                1150
Ser Gln Asn Ile Ser Thr Pro Ser Glu Gln Gln Gln Pro Leu Ala Arg
        1155                1160                1165
Ile Leu Ser Gly Lys Thr Glu Tyr Met Ala Phe Pro Lys Pro Phe Glu
    1170                1175                1180
Ser Ser Ser Ser Ile Gly Ala Glu Lys Pro Arg Asn Lys Lys Leu Pro
1185                1190                1195                1200
Glu Glu Glu Val Glu Ser Ser Arg Thr Pro Trp Leu Tyr Glu Gln Glu
                1205                1210                1215
Gly Glu Val Glu Lys Pro Phe Ile Lys Thr Gly Phe Ser Val Ser Val
            1220                1225                1230
Glu Lys Ser Thr Ser Ser Asn Arg Lys Asn Gln Leu Asp Thr Asn Gly
        1235                1240                1245
Arg Arg Arg Gln Phe Asp Glu Glu Ser Leu Glu Ser Phe Ser Ser Met
    1250                1255                1260
Pro Asp Pro Val Asp Pro Thr Thr Val Thr Lys Thr Phe Lys Thr Arg
1265                1270                1275                1280
Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr Pro Lys
                1285                1290                1295
Ser Lys Ser Lys Lys Arg Asn Ser Thr Gln Leu Lys Ser Arg Val Lys
            1300                1305                1310
Asn Ile Arg Tyr Glu Ser Ala Ser Met Ser Ser Thr Cys Glu Pro Cys
        1315                1320                1325
Lys Ser Arg Asn Arg His Ser Ala Gln Thr Glu Glu Pro Leu Gln Ala
    1330                1335                1340
Lys Val Phe Ser Arg Lys Asn His Glu Gln Leu Glu Lys Ile Ile Lys
1345                1350                1355                1360
Cys Asn Arg Ser Thr Glu Ile Ser Ser Glu Thr Gly Ser Asp Phe Ser
                1365                1370                1375
Met Phe Glu Ala Leu Gln Asp Thr Ile Tyr Ser Glu Val Ala Thr Leu
            1380                1385                1390
Ile Ser Gln Asn Glu Ser Arg Pro His Phe Leu Ile Glu Leu Phe His
        1395                1400                1405
Glu Leu Gln Leu Leu Asn Thr Asp Tyr Leu Arg Gln Arg Ala Leu Tyr
    1410                1415                1420
Ala Leu Gln Asp Ile Val Ser Arg His Ile Ser Glu Ser His Glu Lys
1425                1430                1435                1440
Gly Glu Asn Val Lys Ser Val Asn Ser Gly Thr Trp Ile Ala Ser Asn
                1445                1450                1455
Ser Glu Leu Thr Pro Ser Glu Ser Leu Ala Thr Thr Asp Asp Glu Thr
            1460                1465                1470
Phe Glu Lys Asn Phe Glu Arg Glu Thr His Lys Ile Ser Glu Gln Asn
        1475                1480                1485
Asp Ala Asp Asn Ala Ser Val Leu Ser Val Ser Ser Asn Phe Glu Pro
    1490                1495                1500
Phe Ala Thr Asp Asp Leu Gly Asn Thr Val Ile His Leu Asp Gln Ala
1505                1510                1515                1520
Leu Ala Arg Met Arg Glu Tyr Glu Arg Met Lys Thr Glu Ala Glu Ser
                1525                1530                1535
Asn Ser Asn Met Arg Cys Thr Cys Arg Ile Ile Glu Asp Gly Asp Gly
            1540                1545                1550
Ala Gly Ala Gly Thr Thr Val Asn Asn Leu Glu Glu Thr Pro Val Ile
        1555                1560                1565
Glu Asn Arg Ser Ser Gln Gln Pro Val Ser Glu Val Ser Thr Ile Pro
    1570                1575                1580
Cys Pro Arg Ile Asp Thr Gln Gln Leu Asp Arg Gln Ile Lys Ala Ile
1585                1590                1595                1600
Met Lys Glu Val Ile Pro Phe Leu Lys Glu His Met Asp Glu Val Cys
                1605                1610                1615
Ser Ser Gln Leu Leu Thr Ser Val Arg Arg Met Val Leu Thr Leu Thr
            1620                1625                1630
Gln Gln Asn Asp Glu Ser Lys Glu Phe Val Lys Phe Phe His Lys Gln
        1635                1640                1645
Leu Gly Ser Ile Leu Gln Asp Ser Leu Ala Lys Phe Ala Gly Arg Lys
    1650                1655                1660
Leu Lys Asp Cys Gly Glu Asp Leu Leu Val Glu Ile Ser Glu Val Leu
1665                1670                1675                1680
Phe Asn Glu Leu Ala Phe Phe Lys Leu Met Gln Asp Leu Asp Asn Asn
                1685                1690                1695
Ser Ile Thr Val Lys Gln Arg Cys Lys Arg Lys Ile Glu Ala Thr Gly
            1700                1705                1710
Val Ile Gln Ser Cys Ala Lys Glu Ala Lys Arg Ile Leu Glu Asp His
        1715                1720                1725
Gly Ser Pro Ala Gly Glu Ile Asp Asp Glu Asp Lys Asp Lys Asp Glu
    1730                1735                1740
Thr Glu Thr Val Lys Gln Thr Gln Thr Ser Glu Val Tyr Asp Gly Pro
1745                1750                1755                1760
Lys Asn Val Arg Ser Asp Ile Ser Asp Gln Glu Glu Asp Glu Glu Ser
                1765                1770                1775
Glu Gly Cys Pro Val Ser Ile Asn Leu Ser Lys Ala Glu Thr Gln Ala
            1780                1785                1790
Leu Thr Asn Tyr Gly Ser Gly Glu Asp Glu Asn Glu Asp Glu Glu Met
        1795                1800                1805
Glu Glu Phe Glu Glu Gly Pro Val Asp Val Gln Thr Ser Leu Gln Ala
    1810                1815                1820
Asn Thr Glu Ala Thr Glu Glu Asn Glu His Asp Glu Gln Val Leu Gln
1825                1830                1835                1840
Arg Asp Phe Lys Lys Thr Ala Glu Ser Lys Asn Val His Trp Asn Glu
                1845                1850                1855
Lys Pro Leu Val Lys Met Thr Lys Asn Asn Cys Pro Val Lys Pro Ser
            1860                1865                1870
Tyr Leu Asn Ile Leu Glu Asp Glu Gln Pro Leu Asn Ser Ala Ala His
        1875                1880                1885
Lys Glu Ser Pro Pro Thr Val Asp Ser Thr Gln Gln Pro Asn Pro Leu
    1890                1895                1900
Pro Leu Arg Leu Pro Glu Met Glu Pro Leu Val Pro Arg Val Lys Glu
1905                1910                1915                1920
Val Lys Ser Ala Gln Glu Thr Pro Glu Ser Ser Leu Ala Gly Ser Pro
                1925                1930                1935
Asp Thr Glu Ser Pro Val Leu Val Asn Asp Tyr Glu Ala Glu Ser Gly
            1940                1945                1950
Asn Ile Ser Gln Lys Ser Asp Glu Glu Asp Phe Val Lys Val Glu Asp
        1955                1960                1965
Leu Pro Leu Lys Leu Thr Ile Tyr Ser Glu Ala Asp Leu Arg Lys Lys
    1970                1975                1980
Met Val Glu Glu Glu Gln Lys Asn His Leu Ser Gly Glu Met Cys Glu
1985                1990                1995                2000
Met Gln Thr Glu Glu Leu Ala Gly Asn Ser Glu Thr Leu Lys Glu Pro
                2005                2010                2015
Glu Thr Val Gly Ala Gln Ser Ile
            2020

<210> 1558
<211> 2024
<212> PRT
<213> Homo sapiens

<400> 1558
Met Ala Thr Gly Gly Gly Pro Phe Glu Asp Gly Met Asn Asp Gln Asp
 1               5                  10                  15
Leu Pro Asn Trp Ser Asn Glu Asn Val Asp Asp Arg Leu Asn Asn Met
            20                  25                  30
Asp Trp Gly Ala Gln Gln Lys Lys Ala Asn Arg Ser Ser Glu Lys Asn
        35                  40                  45
Lys Lys Lys Phe Gly Val Glu Ser Asp Lys Arg Val Thr Asn Asp Ile
    50                  55                  60
Ser Pro Glu Ser Ser Pro Gly Val Gly Arg Arg Arg Thr Lys Thr Pro
65                  70                  75                  80
His Thr Phe Pro His Ser Arg Tyr Met Ser Gln Met Ser Val Pro Glu
                85                  90                  95
Gln Ala Glu Leu Glu Lys Leu Lys Gln Arg Ile Asn Phe Ser Asp Leu
            100                 105                 110
Asp Gln Arg Ser Ile Gly Ser Asp Ser Gln Gly Arg Ala Thr Ala Ala
        115                 120                 125
Asn Asn Lys Arg Gln Leu Ser Glu Asn Arg Lys Pro Phe Asn Phe Leu
    130                 135                 140
Pro Met Gln Ile Asn Thr Asn Lys Ser Lys Asp Ala Ser Thr Ser Pro
145                 150                 155                 160
Pro Asn Arg Glu Thr Ile Gly Ser Ala Gln Cys Lys Glu Leu Phe Ala
                165                 170                 175
Ser Ala Leu Ser Asn Asp Leu Leu Gln Asn Cys Gln Val Ser Glu Glu
            180                 185                 190
Asp Gly Arg Gly Glu Pro Ala Met Glu Ser Ser Gln Ile Val Ser Arg
        195                 200                 205
Leu Val Gln Ile Arg Asp Tyr Ile Thr Lys Ala Ser Ser Met Arg Glu
    210                 215                 220
Asp Leu Val Glu Lys Asn Glu Arg Ser Ala Asn Val Glu Arg Leu Thr
225                 230                 235                 240
His Leu Ile Asp His Leu Lys Glu Gln Glu Lys Ser Tyr Met Lys Phe
                245                 250                 255
Leu Lys Lys Ile Leu Ala Arg Asp Pro Gln Gln Glu Pro Met Glu Glu
            260                 265                 270
Ile Glu Asn Leu Lys Lys Gln His Asp Leu Leu Lys Arg Met Leu Gln
        275                 280                 285
Gln Gln Glu Gln Leu Arg Gly Ala Leu Gln Gly Arg Gln Ala Ala Leu
    290                 295                 300
Leu Ala Leu Gln His Lys Ala Asp Glu Ala Ile Ala Val Met Asp Asp
305                 310                 315                 320
Ser Val Val Ala Glu Thr Ala Gly Ser Leu Ser Gly Val Ser Ile Thr
                325                 330                 335
Ser Glu Leu Asn Glu Glu Leu Asn Asp Leu Ile Gln Arg Phe His Asn
            340                 345                 350
Gln Leu Arg Asp Ser Gln Pro Pro Ala Val Pro Asp Asn Arg Arg Gln
        355                 360                 365
Ala Glu Ser Leu Ser Leu Thr Arg Glu Val Ser Gln Ser Arg Lys Pro
    370                 375                 380
Ser Ala Ser Glu Arg Leu Pro Asp Glu Lys Val Glu Leu Phe Ser Lys
385                 390                 395                 400
Met Arg Val Leu Gln Glu Lys Lys Gln Lys Met Asp Lys Leu Leu Gly
                405                 410                 415
Glu Leu His Thr Leu Arg Asp Gln His Leu Asn Asn Ser Ser Ser Ser
            420                 425                 430
Pro Gln Arg Ser Val Asp Gln Arg Ser Thr Ser Ala Pro Ser Ala Cys
        435                 440                 445
Leu Gly Leu Ala Pro Val Val Asn Gly Glu Ser Asn Ser Leu Thr Ser
    450                 455                 460
Ser Val Pro Tyr Pro Thr Ala Ser Leu Val Ser Gln Asn Glu Ser Glu
465                 470                 475                 480
Asn Glu Gly His Leu Asn Pro Ser Glu Lys Leu Gln Lys Leu Asn Glu
                485                 490                 495
Val Arg Lys Arg Leu Asn Glu Leu Arg Glu Leu Val His Tyr Tyr Glu
            500                 505                 510
Gln Thr Ser Asp Met Met Thr Asp Ala Val Asn Glu Asn Arg Lys Asp
        515                 520                 525
Glu Glu Thr Glu Glu Ser Glu Tyr Asp Ser Glu His Glu Asn Ser Glu
    530                 535                 540
Pro Val Thr Asn Ile Arg Asn Pro Gln Val Ala Ser Thr Trp Asn Glu
545                 550                 555                 560
Val Asn Ser His Ser Asn Ala Gln Cys Val Ser Asn Asn Arg Asp Gly
                565                 570                 575
Arg Thr Val Asn Ser Asn Cys Glu Ile Asn Asn Arg Ser Ala Ala Asn
            580                 585                 590
Ile Arg Ala Leu Asn Val Pro Pro Ser Leu Asp Cys Arg Tyr Asn Arg
        595                 600                 605
Glu Gly Glu Gln Glu Ile His Val Ala Gln Gly Glu Asp Asp Glu Glu
    610                 615                 620
Glu Glu Glu Glu Ala Glu Glu Glu Gly Val Ser Gly Ala Ser Leu Ser
625                 630                 635                 640
Ser His Arg Ser Ser Leu Val Asp Glu His Pro Glu Asp Ala Glu Phe
                645                 650                 655
Glu Gln Lys Ile Asn Arg Leu Met Ala Ala Lys Gln Lys Leu Arg Gln
            660                 665                 670
Leu Gln Asp Leu Val Ala Met Val Gln Asp Asp Asp Ala Ala Gln Gly
        675                 680                 685
Val Ile Ser Ala Ser Ala Ser Asn Leu Asp Asp Phe Tyr Pro Ala Glu
    690                 695                 700
Glu Asp Thr Lys Gln Asn Ser Asn Asn Thr Arg Gly Asn Ala Asn Lys
705                 710                 715                 720
Thr Gln Lys Asp Thr Gly Val Asn Glu Lys Ala Arg Glu Lys Phe Tyr
                725                 730                 735
Glu Ala Lys Leu Gln Gln Gln Gln Arg Glu Leu Lys Gln Leu Gln Glu
            740                 745                 750
Glu Arg Lys Lys Leu Ile Asp Ile His Glu Lys Ile Gln Ala Leu Gln
        755                 760                 765
Thr Ala Cys Pro Asp Leu Gln Leu Ser Ala Ala Ser Val Gly Asn Cys
    770                 775                 780
Pro Thr Lys Lys Tyr Met Pro Ala Val Thr Ser Thr Pro Thr Val Asn
785                 790                 795                 800
Gln His Glu Thr Ser Thr Ser Lys Ser Val Phe Glu Pro Glu Asp Ser
                805                 810                 815
Ser Ile Val Asp Asn Glu Leu Trp Ser Glu Met Arg Arg His Glu Met
            820                 825                 830
Leu Arg Glu Glu Leu Arg Gln Arg Arg Lys Gln Leu Glu Ala Leu Met
        835                 840                 845
Ala Glu His Gln Arg Arg Gln Gly Leu Ala Glu Thr Ala Ser Pro Val
    850                 855                 860
Ala Val Ser Leu Arg Ser Asp Gly Ser Glu Asn Leu Cys Thr Pro Gln
865                 870                 875                 880
Gln Ser Arg Thr Glu Lys Thr Met Ala Thr Trp Gly Gly Ser Thr Gln
                885                 890                 895
Cys Ala Leu Asp Glu Glu Gly Asp Glu Asp Gly Tyr Leu Ser Glu Gly
            900                 905                 910
Ile Val Arg Thr Asp Glu Glu Glu Glu Glu Glu Gln Asp Ala Ser Ser
        915                 920                 925
Asn Asp Asn Phe Ser Val Cys Pro Ser Asn Ser Val Asn His Asn Ser
    930                 935                 940
Tyr Asn Arg Lys Glu Thr Lys Asn Thr Trp Lys Asn Asn Cys Pro Phe
945                 950                 955                 960
Ser Ala Asp Glu Asn Tyr Arg Pro Leu Ala Lys Thr Arg Gln Gln Asn
                965                 970                 975
Ile Ser Met Gln Arg Gln Glu Asn Leu Arg Trp Val Ser Glu Leu Ser
            980                 985                 990
Tyr Val Glu Glu Lys Glu Gln Trp Gln Glu Gln Ile Gln Leu Lys Lys
        995                 1000                1005
Gln Leu Asp Phe Ser Val Ser Ile Cys Gln Thr Leu Met Gln Asp Gln
    1010                1015                1020
Gln Thr Leu Ser Cys Leu Leu Gln Thr Leu Leu Thr Gly Pro Tyr Ser
1025                1030                1035                1040
Val Met Pro Ser Asn Val Ala Ser Pro Gln Val His Phe Ile Met His
                1045                1050                1055
Gln Leu Asn Gln Cys Tyr Thr Gln Leu Thr Trp Gln Gln Asn Asn Val
            1060                1065                1070
Gln Arg Leu Lys Gln Met Leu Asn Glu Leu Met Arg Gln Arg Asn Gln
        1075                1080                1085
His Pro Glu Lys Pro Gly Gly Lys Glu Arg Gly Ser Ser Ala Ser His
    1090                1095                1100
Pro Pro Ser Pro Ser Leu Phe Cys Pro Phe Ser Phe Pro Thr Gln Pro
1105                1110                1115                1120
Val Asn Leu Phe Asn Ile Pro Gly Phe Thr Asn Phe Ser Ser Phe Ala
                1125                1130                1135
Pro Gly Met Asn Phe Ser Pro Leu Phe Pro Ser Asn Phe Gly Asp Phe
            1140                1145                1150
Ser Gln Asn Ile Ser Thr Pro Ser Glu Gln Gln Gln Pro Leu Ala Arg
        1155                1160                1165
Ile Leu Ser Gly Lys Thr Glu Tyr Met Ala Phe Pro Lys Pro Phe Glu
    1170                1175                1180
Ser Ser Ser Ser Ile Gly Ala Glu Lys Pro Arg Asn Lys Lys Leu Pro
1185                1190                1195                1200
Glu Glu Glu Val Glu Ser Ser Arg Thr Pro Trp Leu Tyr Glu Gln Glu
                1205                1210                1215
Gly Glu Val Glu Lys Pro Phe Ile Lys Thr Gly Phe Ser Val Ser Val
            1220                1225                1230
Glu Lys Ser Thr Ser Ser Asn Arg Lys Asn Gln Leu Asp Thr Asn Gly
        1235                1240                1245
Arg Arg Arg Gln Phe Asp Glu Glu Ser Leu Glu Ser Phe Ser Ser Met
    1250                1255                1260
Pro Asp Pro Val Asp Pro Thr Thr Val Thr Lys Thr Phe Lys Thr Arg
1265                1270                1275                1280
Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr Pro Lys
                1285                1290                1295
Ser Lys Ser Lys Lys Arg Asn Ser Thr Gln Leu Lys Ser Arg Val Lys
            1300                1305                1310
Asn Ile Arg Tyr Glu Ser Ala Ser Met Ser Ser Thr Cys Glu Pro Cys
        1315                1320                1325
Lys Ser Arg Asn Arg His Ser Ala Gln Thr Glu Glu Pro Leu Gln Ala
    1330                1335                1340
Lys Val Phe Ser Arg Lys Asn His Glu Gln Leu Glu Lys Ile Ile Lys
1345                1350                1355                1360
Cys Asn Arg Ser Thr Glu Ile Ser Ser Glu Thr Gly Ser Asp Phe Ser
                1365                1370                1375
Met Phe Glu Ala Leu Gln Asp Thr Ile Tyr Ser Glu Val Ala Thr Leu
            1380                1385                1390
Ile Ser Gln Asn Glu Ser Arg Pro His Phe Leu Ile Glu Leu Phe His
        1395                1400                1405
Glu Leu Gln Leu Leu Asn Thr Asp Tyr Leu Arg Gln Arg Ala Leu Tyr
    1410                1415                1420
Ala Leu Gln Asp Ile Val Ser Arg His Ile Ser Glu Ser His Glu Lys
1425                1430                1435                1440
Gly Glu Asn Val Lys Ser Val Asn Ser Gly Thr Trp Ile Ala Ser Asn
                1445                1450                1455
Ser Glu Leu Thr Pro Ser Glu Ser Leu Ala Thr Thr Asp Asp Glu Thr
            1460                1465                1470
Phe Glu Lys Asn Phe Glu Arg Glu Thr His Lys Ile Ser Glu Gln Asn
        1475                1480                1485
Asp Ala Asp Asn Ala Ser Val Leu Ser Val Ser Ser Asn Phe Glu Pro
    1490                1495                1500
Phe Ala Thr Asp Asp Leu Gly Asn Thr Val Ile His Leu Asp Gln Ala
1505                1510                1515                1520
Leu Ala Arg Met Arg Glu Tyr Glu Arg Met Lys Thr Glu Ala Glu Ser
                1525                1530                1535
Asn Ser Asn Met Arg Cys Thr Cys Arg Ile Ile Glu Asp Gly Asp Gly
            1540                1545                1550
Ala Gly Ala Gly Thr Thr Val Asn Asn Leu Glu Glu Thr Pro Val Ile
        1555                1560                1565
Glu Asn Arg Ser Ser Gln Gln Pro Val Ser Glu Val Ser Thr Ile Pro
    1570                1575                1580
Cys Pro Arg Ile Asp Thr Gln Gln Leu Asp Arg Gln Ile Lys Ala Ile
1585                1590                1595                1600
Met Lys Glu Val Ile Pro Phe Leu Lys Glu His Met Asp Glu Val Cys
                1605                1610                1615
Ser Ser Gln Leu Leu Thr Ser Val Arg Arg Met Val Leu Thr Leu Thr
            1620                1625                1630
Gln Gln Asn Asp Glu Ser Lys Glu Phe Val Lys Phe Phe His Lys Gln
        1635                1640                1645
Leu Gly Ser Ile Leu Gln Asp Ser Leu Ala Lys Phe Ala Gly Arg Lys
    1650                1655                1660
Leu Lys Asp Cys Gly Glu Asp Leu Leu Val Glu Ile Ser Glu Val Leu
1665                1670                1675                1680
Phe Asn Glu Leu Ala Phe Phe Lys Leu Met Gln Asp Leu Asp Asn Asn
                1685                1690                1695
Ser Ile Thr Val Lys Gln Arg Cys Lys Arg Lys Ile Glu Ala Thr Gly
            1700                1705                1710
Val Ile Gln Ser Cys Ala Lys Glu Ala Lys Arg Ile Leu Glu Asp His
        1715                1720                1725
Gly Ser Pro Ala Gly Glu Ile Asp Asp Glu Asp Lys Asp Lys Asp Glu
    1730                1735                1740
Thr Glu Thr Val Lys Gln Thr Gln Thr Ser Glu Val Tyr Asp Gly Pro
1745                1750                1755                1760
Lys Asn Val Arg Ser Asp Ile Ser Asp Gln Glu Glu Asp Glu Glu Ser
                1765                1770                1775
Glu Gly Cys Pro Val Ser Ile Asn Leu Ser Lys Ala Glu Thr Gln Ala
            1780                1785                1790
Leu Thr Asn Tyr Gly Ser Gly Glu Asp Glu Asn Glu Asp Glu Glu Met
        1795                1800                1805
Glu Glu Phe Glu Glu Gly Pro Val Asp Val Gln Thr Ser Leu Gln Ala
    1810                1815                1820
Asn Thr Glu Ala Thr Glu Glu Asn Glu His Asp Glu Gln Val Leu Gln
1825                1830                1835                1840
Arg Asp Phe Lys Lys Thr Ala Glu Ser Lys Asn Val His Trp Asn Glu
                1845                1850                1855
Lys Pro Leu Val Lys Met Thr Lys Asn Asn Cys Pro Val Lys Pro Ser
            1860                1865                1870
Tyr Leu Asn Ile Leu Glu Asp Glu Gln Pro Leu Asn Ser Ala Ala His
        1875                1880                1885
Lys Glu Ser Pro Pro Thr Val Asp Ser Thr Gln Gln Pro Asn Pro Leu
    1890                1895                1900
Pro Leu Arg Leu Pro Glu Met Glu Pro Leu Val Pro Arg Val Lys Glu
1905                1910                1915                1920
Val Lys Ser Ala Gln Glu Thr Pro Glu Ser Ser Leu Ala Gly Ser Pro
                1925                1930                1935
Asp Thr Glu Ser Pro Val Leu Val Asn Asp Tyr Glu Ala Glu Ser Gly
            1940                1945                1950
Asn Ile Ser Gln Lys Ser Asp Glu Glu Asp Phe Val Lys Val Glu Asp
        1955                1960                1965
Leu Pro Leu Lys Leu Thr Ile Tyr Ser Glu Ala Asp Leu Arg Lys Lys
    1970                1975                1980
Met Val Glu Glu Glu Gln Lys Asn His Leu Ser Gly Glu Met Cys Glu
1985                1990                1995                2000
Met Gln Thr Glu Glu Leu Ala Gly Asn Ser Glu Thr Leu Lys Glu Pro
                2005                2010                2015
Glu Thr Val Gly Ala Gln Ser Ile
            2020

<210> 1559
<211> 2024
<212> PRT
<213> Homo sapiens

<400> 1559
Met Ala Thr Gly Gly Gly Pro Phe Glu Asp Gly Met Asn Asp Gln Asp
 1               5                  10                  15
Leu Pro Asn Trp Ser Asn Glu Asn Val Asp Asp Arg Leu Asn Asn Met
            20                  25                  30
Asp Trp Gly Ala Gln Gln Lys Lys Ala Asn Arg Ser Ser Glu Lys Asn
        35                  40                  45
Lys Lys Lys Phe Gly Val Glu Ser Asp Lys Arg Val Thr Asn Asp Ile
    50                  55                  60
Ser Pro Glu Ser Ser Pro Gly Val Gly Arg Arg Arg Thr Lys Thr Pro
65                  70                  75                  80
His Thr Phe Pro His Ser Arg Tyr Met Ser Gln Met Ser Val Pro Glu
                85                  90                  95
Gln Ala Glu Leu Glu Lys Leu Lys Gln Arg Ile Asn Phe Ser Asp Leu
            100                 105                 110
Asp Gln Arg Ser Ile Gly Ser Asp Ser Gln Gly Arg Ala Thr Ala Ala
        115                 120                 125
Asn Asn Lys Arg Gln Leu Ser Glu Asn Arg Lys Pro Phe Asn Phe Leu
    130                 135                 140
Pro Met Gln Ile Asn Thr Asn Lys Ser Lys Asp Ala Ser Thr Ser Pro
145                 150                 155                 160
Pro Asn Arg Glu Thr Ile Gly Ser Ala Gln Cys Lys Glu Leu Phe Ala
                165                 170                 175
Ser Ala Leu Ser Asn Asp Leu Leu Gln Asn Cys Gln Val Ser Glu Glu
            180                 185                 190
Asp Gly Arg Gly Glu Pro Ala Met Glu Ser Ser Gln Ile Val Ser Arg
        195                 200                 205
Leu Val Gln Ile Arg Asp Tyr Ile Thr Lys Ala Ser Ser Met Arg Glu
    210                 215                 220
Asp Leu Val Glu Lys Asn Glu Arg Ser Ala Asn Val Glu Arg Leu Thr
225                 230                 235                 240
His Leu Ile Asp His Leu Lys Glu Gln Glu Lys Ser Tyr Met Lys Phe
                245                 250                 255
Leu Lys Lys Ile Leu Ala Arg Asp Pro Gln Gln Glu Pro Met Glu Glu
            260                 265                 270
Ile Glu Asn Leu Lys Lys Gln His Asp Leu Leu Lys Arg Met Leu Gln
        275                 280                 285
Gln Gln Glu Gln Leu Arg Gly Ala Leu Gln Gly Arg Gln Ala Ala Leu
    290                 295                 300
Leu Ala Leu Gln His Lys Ala Asp Glu Ala Ile Ala Val Met Asp Asp
305                 310                 315                 320
Ser Val Val Ala Glu Thr Ala Gly Ser Leu Ser Gly Val Ser Ile Thr
                325                 330                 335
Ser Glu Leu Asn Glu Glu Leu Asn Asp Leu Ile Gln Arg Phe His Asn
            340                 345                 350
Gln Leu Arg Asp Ser Gln Pro Pro Ala Val Pro Asp Asn Arg Arg Gln
        355                 360                 365
Ala Glu Ser Leu Ser Leu Thr Arg Glu Val Ser Gln Ser Arg Lys Pro
    370                 375                 380
Ser Ala Ser Glu Arg Leu Pro Asp Glu Lys Val Glu Leu Phe Ser Lys
385                 390                 395                 400
Met Arg Val Leu Gln Glu Lys Lys Gln Lys Met Asp Lys Leu Leu Gly
                405                 410                 415
Glu Leu His Thr Leu Arg Asp Gln His Leu Asn Asn Ser Ser Ser Ser
            420                 425                 430
Pro Gln Arg Ser Val Asp Gln Arg Ser Thr Ser Ala Pro Ser Ala Cys
        435                 440                 445
Leu Gly Leu Ala Pro Val Val Asn Gly Glu Ser Asn Ser Leu Thr Ser
    450                 455                 460
Ser Val Pro Tyr Pro Thr Ala Ser Leu Val Ser Gln Asn Glu Ser Glu
465                 470                 475                 480
Asn Glu Gly His Leu Asn Pro Ser Glu Lys Leu Gln Lys Leu Asn Glu
                485                 490                 495
Val Arg Lys Arg Leu Asn Glu Leu Arg Glu Leu Val His Tyr Tyr Glu
            500                 505                 510
Gln Thr Ser Asp Met Met Thr Asp Ala Val Asn Glu Asn Arg Lys Asp
        515                 520                 525
Glu Glu Thr Glu Glu Ser Glu Tyr Asp Ser Glu His Glu Asn Ser Glu
    530                 535                 540
Pro Val Thr Asn Ile Arg Asn Pro Gln Val Ala Ser Thr Trp Asn Glu
545                 550                 555                 560
Val Asn Ser His Ser Asn Ala Gln Cys Val Ser Asn Asn Arg Asp Gly
                565                 570                 575
Arg Thr Val Asn Ser Asn Cys Glu Ile Asn Asn Arg Ser Ala Ala Asn
            580                 585                 590
Ile Arg Ala Leu Asn Val Pro Pro Ser Leu Asp Cys Arg Tyr Asn Arg
        595                 600                 605
Glu Gly Glu Gln Glu Ile His Val Ala Gln Gly Glu Asp Asp Glu Glu
    610                 615                 620
Glu Glu Glu Glu Ala Glu Glu Glu Gly Val Ser Gly Ala Ser Leu Ser
625                 630                 635                 640
Ser His Arg Ser Ser Leu Val Asp Glu His Pro Glu Asp Ala Glu Phe
                645                 650                 655
Glu Gln Lys Ile Asn Arg Leu Met Ala Ala Lys Gln Lys Leu Arg Gln
            660                 665                 670
Leu Gln Asp Leu Val Ala Met Val Gln Asp Asp Asp Ala Ala Gln Gly
        675                 680                 685
Val Ile Ser Ala Ser Ala Ser Asn Leu Asp Asp Phe Tyr Pro Ala Glu
    690                 695                 700
Glu Asp Thr Lys Gln Asn Ser Asn Asn Thr Arg Gly Asn Ala Asn Lys
705                 710                 715                 720
Thr Gln Lys Asp Thr Gly Val Asn Glu Lys Ala Arg Glu Lys Phe Tyr
                725                 730                 735
Glu Ala Lys Leu Gln Gln Gln Gln Arg Glu Leu Lys Gln Leu Gln Glu
            740                 745                 750
Glu Arg Lys Lys Leu Ile Asp Ile His Glu Lys Ile Gln Ala Leu Gln
        755                 760                 765
Thr Ala Cys Pro Asp Leu Gln Leu Ser Ala Ala Ser Val Gly Asn Cys
    770                 775                 780
Pro Thr Lys Lys Tyr Met Pro Ala Val Thr Ser Thr Pro Thr Val Asn
785                 790                 795                 800
Gln His Glu Thr Ser Thr Ser Lys Ser Val Phe Glu Pro Glu Asp Ser
                805                 810                 815
Ser Ile Val Asp Asn Glu Leu Trp Ser Glu Met Arg Arg His Glu Met
            820                 825                 830
Leu Arg Glu Glu Leu Arg Gln Arg Arg Lys Gln Leu Glu Ala Leu Met
        835                 840                 845
Ala Glu His Gln Arg Arg Gln Gly Leu Ala Glu Thr Ala Ser Pro Val
    850                 855                 860
Ala Val Ser Leu Arg Ser Asp Gly Ser Glu Asn Leu Cys Thr Pro Gln
865                 870                 875                 880
Gln Ser Arg Thr Glu Lys Thr Met Ala Thr Trp Gly Gly Ser Thr Gln
                885                 890                 895
Cys Ala Leu Asp Glu Glu Gly Asp Glu Asp Gly Tyr Leu Ser Glu Gly
            900                 905                 910
Ile Val Arg Thr Asp Glu Glu Glu Glu Glu Glu Gln Asp Ala Ser Ser
        915                 920                 925
Asn Asp Asn Phe Ser Val Cys Pro Ser Asn Ser Val Asn His Asn Ser
    930                 935                 940
Tyr Asn Arg Lys Glu Thr Lys Asn Thr Trp Lys Asn Asn Cys Pro Phe
945                 950                 955                 960
Ser Ala Asp Glu Asn Tyr Arg Pro Leu Ala Lys Thr Arg Gln Gln Asn
                965                 970                 975
Ile Ser Met Gln Arg Gln Glu Asn Leu Arg Trp Val Ser Glu Leu Ser
            980                 985                 990
Tyr Val Glu Glu Lys Glu Gln Trp Gln Glu Gln Ile Gln Leu Lys Lys
        995                 1000                1005
Gln Leu Asp Phe Ser Val Ser Ile Cys Gln Thr Leu Met Gln Asp Gln
    1010                1015                1020
Gln Thr Leu Ser Cys Leu Leu Gln Thr Leu Leu Thr Gly Pro Tyr Ser
1025                1030                1035                1040
Val Met Pro Ser Asn Val Ala Ser Pro Gln Val His Phe Ile Met His
                1045                1050                1055
Gln Leu Asn Gln Cys Tyr Thr Gln Leu Thr Trp Gln Gln Asn Asn Val
            1060                1065                1070
Gln Arg Leu Lys Gln Met Leu Asn Glu Leu Met Arg Gln Arg Asn Gln
        1075                1080                1085
His Pro Glu Lys Pro Gly Gly Lys Glu Arg Gly Ser Ser Ala Ser His
    1090                1095                1100
Pro Pro Ser Pro Ser Leu Phe Cys Pro Phe Ser Phe Pro Thr Gln Pro
1105                1110                1115                1120
Val Asn Leu Phe Asn Ile Pro Gly Phe Thr Asn Phe Ser Ser Phe Ala
                1125                1130                1135
Pro Gly Met Asn Phe Ser Pro Leu Phe Pro Ser Asn Phe Gly Asp Phe
            1140                1145                1150
Ser Gln Asn Ile Ser Thr Pro Ser Glu Gln Gln Gln Pro Leu Ala Arg
        1155                1160                1165
Ile Leu Ser Gly Lys Thr Glu Tyr Met Ala Phe Pro Lys Pro Phe Glu
    1170                1175                1180
Ser Ser Ser Ser Ile Gly Ala Glu Lys Pro Arg Asn Lys Lys Leu Pro
1185                1190                1195                1200
Glu Glu Glu Val Glu Ser Ser Arg Thr Pro Trp Leu Tyr Glu Gln Glu
                1205                1210                1215
Gly Glu Val Glu Lys Pro Phe Ile Lys Thr Gly Phe Ser Val Ser Val
            1220                1225                1230
Glu Lys Ser Thr Ser Ser Asn Arg Lys Asn Gln Leu Asp Thr Asn Gly
        1235                1240                1245
Arg Arg Arg Gln Phe Asp Glu Glu Ser Leu Glu Ser Phe Ser Ser Met
    1250                1255                1260
Pro Asp Pro Val Asp Pro Thr Thr Val Thr Lys Thr Phe Lys Thr Arg
1265                1270                1275                1280
Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr Pro Lys
                1285                1290                1295
Ser Lys Ser Lys Lys Arg Asn Ser Thr Gln Leu Lys Ser Arg Val Lys
            1300                1305                1310
Asn Ile Arg Tyr Glu Ser Ala Ser Met Ser Ser Thr Cys Glu Pro Cys
        1315                1320                1325
Lys Ser Arg Asn Arg His Ser Ala Gln Thr Glu Glu Pro Leu Gln Ala
    1330                1335                1340
Lys Val Phe Ser Arg Lys Asn His Glu Gln Leu Glu Lys Ile Ile Lys
1345                1350                1355                1360
Cys Asn Arg Ser Thr Glu Ile Ser Ser Glu Thr Gly Ser Asp Phe Ser
                1365                1370                1375
Met Phe Glu Ala Leu Gln Asp Thr Ile Tyr Ser Glu Val Ala Thr Leu
            1380                1385                1390
Ile Ser Gln Asn Glu Ser Arg Pro His Phe Leu Ile Glu Leu Phe His
        1395                1400                1405
Glu Leu Gln Leu Leu Asn Thr Asp Tyr Leu Arg Gln Arg Ala Leu Tyr
    1410                1415                1420
Ala Leu Gln Asp Ile Val Ser Arg His Ile Ser Glu Ser His Glu Lys
1425                1430                1435                1440
Gly Glu Asn Val Lys Ser Val Asn Ser Gly Thr Trp Ile Ala Ser Asn
                1445                1450                1455
Ser Glu Leu Thr Pro Ser Glu Ser Leu Ala Thr Thr Asp Asp Glu Thr
            1460                1465                1470
Phe Glu Lys Asn Phe Glu Arg Glu Thr His Lys Ile Ser Glu Gln Asn
        1475                1480                1485
Asp Ala Asp Asn Ala Ser Val Leu Ser Val Ser Ser Asn Phe Glu Pro
    1490                1495                1500
Phe Ala Thr Asp Asp Leu Gly Asn Thr Val Ile His Leu Asp Gln Ala
1505                1510                1515                1520
Leu Ala Arg Met Arg Glu Tyr Glu Arg Met Lys Thr Glu Ala Glu Ser
                1525                1530                1535
Asn Ser Asn Met Arg Cys Thr Cys Arg Ile Ile Glu Asp Gly Asp Gly
            1540                1545                1550
Ala Gly Ala Gly Thr Thr Val Asn Asn Leu Glu Glu Thr Pro Val Ile
        1555                1560                1565
Glu Asn Arg Ser Ser Gln Gln Pro Val Ser Glu Val Ser Thr Ile Pro
    1570                1575                1580
Cys Pro Arg Ile Asp Thr Gln Gln Leu Asp Arg Gln Ile Lys Ala Ile
1585                1590                1595                1600
Met Lys Glu Val Ile Pro Phe Leu Lys Glu His Met Asp Glu Val Cys
                1605                1610                1615
Ser Ser Gln Leu Leu Thr Ser Val Arg Arg Met Val Leu Thr Leu Thr
            1620                1625                1630
Gln Gln Asn Asp Glu Ser Lys Glu Phe Val Lys Phe Phe His Lys Gln
        1635                1640                1645
Leu Gly Ser Ile Leu Gln Asp Ser Leu Ala Lys Phe Ala Gly Arg Lys
    1650                1655                1660
Leu Lys Asp Cys Gly Glu Asp Leu Leu Val Glu Ile Ser Glu Val Leu
1665                1670                1675                1680
Phe Asn Glu Leu Ala Phe Phe Lys Leu Met Gln Asp Leu Asp Asn Asn
                1685                1690                1695
Ser Ile Thr Val Lys Gln Arg Cys Lys Arg Lys Ile Glu Ala Thr Gly
            1700                1705                1710
Val Ile Gln Ser Cys Ala Lys Glu Ala Lys Arg Ile Leu Glu Asp His
        1715                1720                1725
Gly Ser Pro Ala Gly Glu Ile Asp Asp Glu Asp Lys Asp Lys Asp Glu
    1730                1735                1740
Thr Glu Thr Val Lys Gln Thr Gln Thr Ser Glu Val Tyr Asp Gly Pro
1745                1750                1755                1760
Lys Asn Val Arg Ser Asp Ile Ser Asp Gln Glu Glu Asp Glu Glu Ser
                1765                1770                1775
Glu Gly Cys Pro Val Ser Ile Asn Leu Ser Lys Ala Glu Thr Gln Ala
            1780                1785                1790
Leu Thr Asn Tyr Gly Ser Gly Glu Asp Glu Asn Glu Asp Glu Glu Met
        1795                1800                1805
Glu Glu Phe Glu Glu Gly Pro Val Asp Val Gln Thr Ser Leu Gln Ala
    1810                1815                1820
Asn Thr Glu Ala Thr Glu Glu Asn Glu His Asp Glu Gln Val Leu Gln
1825                1830                1835                1840
Arg Asp Phe Lys Lys Thr Ala Glu Ser Lys Asn Val His Trp Asn Glu
                1845                1850                1855
Lys Pro Leu Val Lys Met Thr Lys Asn Asn Cys Pro Val Lys Pro Ser
            1860                1865                1870
Tyr Leu Asn Ile Leu Glu Asp Glu Gln Pro Leu Asn Ser Ala Ala His
        1875                1880                1885
Lys Glu Ser Pro Pro Thr Val Asp Ser Thr Gln Gln Pro Asn Pro Leu
    1890                1895                1900
Pro Leu Arg Leu Pro Glu Met Glu Pro Leu Val Pro Arg Val Lys Glu
1905                1910                1915                1920
Val Lys Ser Ala Gln Glu Thr Pro Glu Ser Ser Leu Ala Gly Ser Pro
                1925                1930                1935
Asp Thr Glu Ser Pro Val Leu Val Asn Asp Tyr Glu Ala Glu Ser Gly
            1940                1945                1950
Asn Ile Ser Gln Lys Ser Asp Glu Glu Asp Phe Val Lys Val Glu Asp
        1955                1960                1965
Leu Pro Leu Lys Leu Thr Ile Tyr Ser Glu Ala Asp Leu Arg Lys Lys
    1970                1975                1980
Met Val Glu Glu Glu Gln Lys Asn His Leu Ser Gly Glu Met Cys Glu
1985                1990                1995                2000
Met Gln Thr Glu Glu Leu Ala Gly Asn Ser Glu Thr Leu Lys Glu Pro
                2005                2010                2015
Glu Thr Val Gly Ala Gln Ser Ile
            2020

<210> 1560
<211> 530
<212> PRT
<213> Homo sapiens

<400> 1560
Met Ala Thr Gly Gly Gly Pro Phe Glu Asp Gly Met Asn Asp Gln Asp
 1               5                  10                  15
Leu Pro Asn Trp Ser Asn Glu Asn Val Asp Asp Arg Leu Asn Asn Met
            20                  25                  30
Asp Trp Gly Ala Gln Gln Lys Lys Ala Asn Arg Ser Ser Glu Lys Asn
        35                  40                  45
Lys Lys Lys Phe Gly Val Glu Ser Asp Lys Arg Val Thr Asn Asp Ile
    50                  55                  60
Ser Pro Glu Ser Ser Pro Gly Val Gly Arg Arg Arg Thr Lys Thr Pro
65                  70                  75                  80
His Thr Phe Pro His Ser Arg Tyr Met Ser Gln Met Ser Val Pro Glu
                85                  90                  95
Gln Ala Glu Leu Glu Lys Leu Lys Gln Arg Ile Asn Phe Ser Asp Leu
            100                 105                 110
Asp Gln Arg Ser Ile Gly Ser Asp Ser Gln Gly Arg Ala Thr Ala Ala
        115                 120                 125
Asn Asn Lys Arg Gln Leu Ser Glu Asn Arg Lys Pro Phe Asn Phe Leu
    130                 135                 140
Pro Met Gln Ile Asn Thr Asn Lys Ser Lys Asp Ala Ser Thr Ser Pro
145                 150                 155                 160
Pro Asn Arg Glu Thr Ile Gly Ser Ala Gln Cys Lys Glu Leu Phe Ala
                165                 170                 175
Ser Ala Leu Ser Asn Asp Leu Leu Gln Asn Cys Gln Val Ser Glu Glu
            180                 185                 190
Asp Gly Arg Gly Glu Pro Ala Met Glu Ser Ser Gln Ile Val Ser Arg
        195                 200                 205
Leu Val Gln Ile Arg Asp Tyr Ile Thr Lys Ala Ser Ser Met Arg Glu
    210                 215                 220
Asp Leu Val Glu Lys Asn Glu Arg Ser Ala Asn Val Glu Arg Leu Thr
225                 230                 235                 240
His Leu Ile Asp His Leu Lys Glu Gln Glu Lys Ser Tyr Met Lys Phe
                245                 250                 255
Leu Lys Lys Ile Leu Ala Arg Glu Asn Glu Glu Glu Asp Val Arg Thr
            260                 265                 270
Ile Asp Ser Ala Val Gly Ser Gly Ser Val Ala Glu Ser Thr Ser Leu
        275                 280                 285
Asn Ile Asp Val Gln Ser Glu Ala Ser Asp Thr Thr Ala Arg Asp Pro
    290                 295                 300
Gln Gln Glu Pro Met Glu Glu Ile Glu Asn Leu Lys Lys Gln His Asp
305                 310                 315                 320
Leu Leu Lys Arg Met Leu Gln Gln Gln Glu Gln Leu Arg Ala Leu Gln
                325                 330                 335
Gly Arg Gln Ala Ala Leu Leu Ala Leu Gln His Lys Ala Glu Gln Ala
            340                 345                 350
Ile Ala Val Met Asp Asp Ser Val Val Ala Glu Thr Ala Gly Ser Leu
        355                 360                 365
Ser Gly Val Ser Ile Thr Ser Glu Leu Asn Glu Glu Leu Asn Asp Leu
    370                 375                 380
Ile Gln Arg Phe His Asn Gln Leu Arg Asp Ser Gln Pro Pro Ala Val
385                 390                 395                 400
Pro Asp Asn Arg Arg Gln Ala Glu Ser Leu Ser Leu Thr Arg Glu Val
                405                 410                 415
Ser Gln Ser Arg Lys Pro Ser Ala Ser Glu Arg Leu Pro Asp Glu Lys
            420                 425                 430
Val Glu Leu Phe Ser Lys Met Arg Val Leu Gln Glu Lys Lys Gln Lys
        435                 440                 445
Met Asp Lys Leu Leu Gly Glu Leu His Thr Leu Arg Asp Gln His Leu
    450                 455                 460
Asn Asn Ser Ser Ser Ser Pro Gln Arg Ser Val Asp Gln Arg Ser Thr
465                 470                 475                 480
Ser Ala Pro Ser Ala Ser Val Gly Leu Ala Pro Val Val Asn Gly Glu
                485                 490                 495
Ser Asn Ser Leu Thr Ser Ser Val Pro Tyr Pro Thr Ala Ser Leu Val
            500                 505                 510
Ser Gln Asn Glu Ser Glu Asn Glu Gly His Leu Asn Pro Ser Glu Lys
        515                 520                 525
Leu Gln
    530

<210> 1561
<211> 1009
<212> PRT
<213> Homo sapiens

<400> 1561
Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu
 1               5                  10                  15
Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp
            20                  25                  30
Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn
        35                  40                  45
Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln
    50                  55                  60
Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile
65                  70                  75                  80
Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His
                85                  90                  95
Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly
            100                 105                 110
Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg
        115                 120                 125
Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu
    130                 135                 140
Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn
145                 150                 155                 160
Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu
                165                 170                 175
Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His
            180                 185                 190
Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val
        195                 200                 205
Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro
    210                 215                 220
Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser
225                 230                 235                 240
Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Pro
                245                 250                 255
Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly
            260                 265                 270
Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln
        275                 280                 285
Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln
    290                 295                 300
Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu
305                 310                 315                 320
Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser
                325                 330                 335
Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys
            340                 345                 350
Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys
        355                 360                 365
Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu
    370                 375                 380
Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp
385                 390                 395                 400
Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro
                405                 410                 415
Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly
            420                 425                 430
Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys
        435                 440                 445
Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr
    450                 455                 460
Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn
465                 470                 475                 480
Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu
                485                 490                 495
Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His
            500                 505                 510
Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu
        515                 520                 525
Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn
    530                 535                 540
Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro
545                 550                 555                 560
Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp
                565                 570                 575
Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met
            580                 585                 590
Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val
        595                 600                 605
Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln
    610                 615                 620
Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys
625                 630                 635                 640
Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr
                645                 650                 655
Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe
            660                 665                 670
Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp
        675                 680                 685
Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile
    690                 695                 700
Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro
705                 710                 715                 720
Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln
                725                 730                 735
Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser
            740                 745                 750
Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu
        755                 760                 765
His Arg His Asn Val Phe Lys Arg His Ser Met Gly Glu Glu Asp Phe
    770                 775                 780
Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu
785                 790                 795                 800
Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val
                805                 810                 815
Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met
            820                 825                 830
Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly
        835                 840                 845
Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala
    850                 855                 860
Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val
865                 870                 875                 880
Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn
                885                 890                 895
Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn
            900                 905                 910
Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu
        915                 920                 925
Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys
    930                 935                 940
Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala
945                 950                 955                 960
Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met
                965                 970                 975
Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp
            980                 985                 990
Ala Val Asp Gln Ala Lys Val Leu Ala Asn Leu Ala His Pro Pro Ala
        995                 1000                1005
Glu


<210> 1562
<211> 1009
<212> PRT
<213> Homo sapiens

<400> 1562
Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu
 1               5                  10                  15
Arg Arg Pro Glu Gly Pro Gly Glu Pro Met Val Val Val Pro Val Asp
            20                  25                  30
Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn
        35                  40                  45
Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln
    50                  55                  60
Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile
65                  70                  75                  80
Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His
                85                  90                  95
Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly
            100                 105                 110
Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg
        115                 120                 125
Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu
    130                 135                 140
Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn
145                 150                 155                 160
Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu
                165                 170                 175
Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His
            180                 185                 190
Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val
        195                 200                 205
Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro
    210                 215                 220
Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser
225                 230                 235                 240
Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly
                245                 250                 255
Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly
            260                 265                 270
Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln
        275                 280                 285
Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln
    290                 295                 300
Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu
305                 310                 315                 320
Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser
                325                 330                 335
Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys
            340                 345                 350
Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys
        355                 360                 365
Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu
    370                 375                 380
Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp
385                 390                 395                 400
Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro
                405                 410                 415
Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly
            420                 425                 430
Glu Gly Leu Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys
        435                 440                 445
Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr
    450                 455                 460
Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn
465                 470                 475                 480
Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu
                485                 490                 495
Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His
            500                 505                 510
Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu
        515                 520                 525
Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn
    530                 535                 540
Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro
545                 550                 555                 560
Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp
                565                 570                 575
Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met
            580                 585                 590
Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val
        595                 600                 605
Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln
    610                 615                 620
Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys
625                 630                 635                 640
Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr
                645                 650                 655
Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe
            660                 665                 670
Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp
        675                 680                 685
Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile
    690                 695                 700
Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro
705                 710                 715                 720
Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln
                725                 730                 735
Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser
            740                 745                 750
Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu
        755                 760                 765
His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe
    770                 775                 780
Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu
785                 790                 795                 800
Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val
                805                 810                 815
Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met
            820                 825                 830
Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly
        835                 840                 845
Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala
    850                 855                 860
Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val
865                 870                 875                 880
Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn
                885                 890                 895
Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn
            900                 905                 910
Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu
        915                 920                 925
Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys
    930                 935                 940
Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala
945                 950                 955                 960
Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met
                965                 970                 975
Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp
            980                 985                 990
Ala Val Asp Gln Ala Lys Val Leu Ala Asn Leu Ala His Pro Pro Ala
        995                 1000                1005
Glu


<210> 1563
<211> 1009
<212> PRT
<213> Homo sapiens

<400> 1563
Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu
 1               5                  10                  15
Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp
            20                  25                  30
Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn
        35                  40                  45
Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln
    50                  55                  60
Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile
65                  70                  75                  80
Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His
                85                  90                  95
Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly
            100                 105                 110
Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg
        115                 120                 125
Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu
    130                 135                 140
Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn
145                 150                 155                 160
Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu
                165                 170                 175
Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His
            180                 185                 190
Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val
        195                 200                 205
Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro
    210                 215                 220
Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser
225                 230                 235                 240
Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly
                245                 250                 255
Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly
            260                 265                 270
Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln
        275                 280                 285
Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln
    290                 295                 300
Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu
305                 310                 315                 320
Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser
                325                 330                 335
Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys
            340                 345                 350
Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys
        355                 360                 365
Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu
    370                 375                 380
Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp
385                 390                 395                 400
Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro
                405                 410                 415
Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly
            420                 425                 430
Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys
        435                 440                 445
Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr
    450                 455                 460
Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn
465                 470                 475                 480
Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu
                485                 490                 495
Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His
            500                 505                 510
Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu
        515                 520                 525
Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn
    530                 535                 540
Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro
545                 550                 555                 560
Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp
                565                 570                 575
Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met
            580                 585                 590
Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val
        595                 600                 605
Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln
    610                 615                 620
Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys
625                 630                 635                 640
Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr
                645                 650                 655
Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe
            660                 665                 670
Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp
        675                 680                 685
Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile
    690                 695                 700
Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro
705                 710                 715                 720
Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln
                725                 730                 735
Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser
            740                 745                 750
Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu
        755                 760                 765
His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe
    770                 775                 780
Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu
785                 790                 795                 800
Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val
                805                 810                 815
Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met
            820                 825                 830
Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly
        835                 840                 845
Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala
    850                 855                 860
Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val
865                 870                 875                 880
Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn
                885                 890                 895
Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn
            900                 905                 910
Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu
        915                 920                 925
Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys
    930                 935                 940
Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala
945                 950                 955                 960
Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met
                965                 970                 975
Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp
            980                 985                 990
Ala Val Asp Gln Ala Lys Val Leu Ala Asn Leu Ala His Pro Pro Ala
        995                 1000                1005
Glu


<210> 1564
<211> 1009
<212> PRT
<213> Homo sapiens

<400> 1564
Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu
 1               5                  10                  15
Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp
            20                  25                  30
Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn
        35                  40                  45
Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln
    50                  55                  60
Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile
65                  70                  75                  80
Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His
                85                  90                  95
Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly
            100                 105                 110
Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg
        115                 120                 125
Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu
    130                 135                 140
Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn
145                 150                 155                 160
Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu
                165                 170                 175
Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His
            180                 185                 190
Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val
        195                 200                 205
Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro
    210                 215                 220
Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser
225                 230                 235                 240
Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly
                245                 250                 255
Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly
            260                 265                 270
Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln
        275                 280                 285
Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln
    290                 295                 300
Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu
305                 310                 315                 320
Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser
                325                 330                 335
Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys
            340                 345                 350
Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys
        355                 360                 365
Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu
    370                 375                 380
Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp
385                 390                 395                 400
Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro
                405                 410                 415
Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly
            420                 425                 430
Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys
        435                 440                 445
Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr
    450                 455                 460
Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn
465                 470                 475                 480
Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu
                485                 490                 495
Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His
            500                 505                 510
Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu
        515                 520                 525
Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn
    530                 535                 540
Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro
545                 550                 555                 560
Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp
                565                 570                 575
Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met
            580                 585                 590
Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val
        595                 600                 605
Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln
    610                 615                 620
Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys
625                 630                 635                 640
Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr
                645                 650                 655
Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe
            660                 665                 670
Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp
        675                 680                 685
Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile
    690                 695                 700
Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro
705                 710                 715                 720
Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln
                725                 730                 735
Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser
            740                 745                 750
Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu
        755                 760                 765
His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe
    770                 775                 780
Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu
785                 790                 795                 800
Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val
                805                 810                 815
Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met
            820                 825                 830
Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly
        835                 840                 845
Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala
    850                 855                 860
Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val
865                 870                 875                 880
Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn
                885                 890                 895
Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn
            900                 905                 910
Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu
        915                 920                 925
Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys
    930                 935                 940
Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala
945                 950                 955                 960
Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met
                965                 970                 975
Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp
            980                 985                 990
Ala Val Asp Gln Ala Lys Val Leu Ala Asn Leu Ala His Pro Pro Ala
        995                 1000                1005
Glu


<210> 1565
<211> 1009
<212> PRT
<213> Homo sapiens

<400> 1565
Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu
 1               5                  10                  15
Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp
            20                  25                  30
Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn
        35                  40                  45
Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln
    50                  55                  60
Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile
65                  70                  75                  80
Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His
                85                  90                  95
Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly
            100                 105                 110
Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg
        115                 120                 125
Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu
    130                 135                 140
Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn
145                 150                 155                 160
Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu
                165                 170                 175
Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His
            180                 185                 190
Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val
        195                 200                 205
Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro
    210                 215                 220
Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser
225                 230                 235                 240
Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly
                245                 250                 255
Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly
            260                 265                 270
Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln
        275                 280                 285
Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln
    290                 295                 300
Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu
305                 310                 315                 320
Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser
                325                 330                 335
Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys
            340                 345                 350
Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys
        355                 360                 365
Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu
    370                 375                 380
Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp
385                 390                 395                 400
Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro
                405                 410                 415
Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly
            420                 425                 430
Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys
        435                 440                 445
Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr
    450                 455                 460
Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn
465                 470                 475                 480
Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu
                485                 490                 495
Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His
            500                 505                 510
Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu
        515                 520                 525
Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn
    530                 535                 540
Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro
545                 550                 555                 560
Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp
                565                 570                 575
Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met
            580                 585                 590
Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val
        595                 600                 605
Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln
    610                 615                 620
Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys
625                 630                 635                 640
Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr
                645                 650                 655
Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe
            660                 665                 670
Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp
        675                 680                 685
Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile
    690                 695                 700
Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro
705                 710                 715                 720
Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln
                725                 730                 735
Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser
            740                 745                 750
Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu
        755                 760                 765
His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe
    770                 775                 780
Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu
785                 790                 795                 800
Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val
                805                 810                 815
Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met
            820                 825                 830
Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly
        835                 840                 845
Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala
    850                 855                 860
Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val
865                 870                 875                 880
Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn
                885                 890                 895
Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn
            900                 905                 910
Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu
        915                 920                 925
Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys
    930                 935                 940
Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala
945                 950                 955                 960
Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met
                965                 970                 975
Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp
            980                 985                 990
Ala Val Asp Gln Ala Lys Val Leu Ala Asn Leu Ala His Pro Pro Ala
        995                 1000                1005
Glu


<210> 1566
<211> 1009
<212> PRT
<213> Homo sapiens

<400> 1566
Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu
 1               5                  10                  15
Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp
            20                  25                  30
Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn
        35                  40                  45
Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln
    50                  55                  60
Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile
65                  70                  75                  80
Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His
                85                  90                  95
Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly
            100                 105                 110
Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg
        115                 120                 125
Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu
    130                 135                 140
Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn
145                 150                 155                 160
Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu
                165                 170                 175
Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His
            180                 185                 190
Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val
        195                 200                 205
Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro
    210                 215                 220
Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser
225                 230                 235                 240
Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly
                245                 250                 255
Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly
            260                 265                 270
Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln
        275                 280                 285
Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln
    290                 295                 300
Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu
305                 310                 315                 320
Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser
                325                 330                 335
Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys
            340                 345                 350
Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys
        355                 360                 365
Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu
    370                 375                 380
Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp
385                 390                 395                 400
Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro
                405                 410                 415
Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly
            420                 425                 430
Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys
        435                 440                 445
Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr
    450                 455                 460
Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn
465                 470                 475                 480
Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu
                485                 490                 495
Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His
            500                 505                 510
Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu
        515                 520                 525
Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn
    530                 535                 540
Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro
545                 550                 555                 560
Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp
                565                 570                 575
Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met
            580                 585                 590
Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val
        595                 600                 605
Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln
    610                 615                 620
Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys
625                 630                 635                 640
Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr
                645                 650                 655
Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe
            660                 665                 670
Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp
        675                 680                 685
Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile
    690                 695                 700
Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro
705                 710                 715                 720
Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln
                725                 730                 735
Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser
            740                 745                 750
Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu
        755                 760                 765
His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe
    770                 775                 780
Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu
785                 790                 795                 800
Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val
                805                 810                 815
Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met
            820                 825                 830
Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly
        835                 840                 845
Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala
    850                 855                 860
Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val
865                 870                 875                 880
Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn
                885                 890                 895
Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn
            900                 905                 910
Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu
        915                 920                 925
Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys
    930                 935                 940
Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala
945                 950                 955                 960
Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met
                965                 970                 975
Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp
            980                 985                 990
Ala Val Asp Gln Ala Lys Val Leu Ala Asn Leu Ala His Pro Pro Ala
        995                 1000                1005
Glu


<210> 1567
<211> 1009
<212> PRT
<213> Homo sapiens

<400> 1567
Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu
 1               5                  10                  15
Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp
            20                  25                  30
Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn
        35                  40                  45
Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln
    50                  55                  60
Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile
65                  70                  75                  80
Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His
                85                  90                  95
Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly
            100                 105                 110
Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg
        115                 120                 125
Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu
    130                 135                 140
Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn
145                 150                 155                 160
Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu
                165                 170                 175
Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His
            180                 185                 190
Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val
        195                 200                 205
Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro
    210                 215                 220
Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser
225                 230                 235                 240
Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly
                245                 250                 255
Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly
            260                 265                 270
Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln
        275                 280                 285
Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln
    290                 295                 300
Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu
305                 310                 315                 320
Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser
                325                 330                 335
Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys
            340                 345                 350
Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys
        355                 360                 365
Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu
    370                 375                 380
Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp
385                 390                 395                 400
Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro
                405                 410                 415
Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly
            420                 425                 430
Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys
        435                 440                 445
Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr
    450                 455                 460
Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn
465                 470                 475                 480
Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu
                485                 490                 495
Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His
            500                 505                 510
Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu
        515                 520                 525
Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn
    530                 535                 540
Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro
545                 550                 555                 560
Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp
                565                 570                 575
Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met
            580                 585                 590
Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val
        595                 600                 605
Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln
    610                 615                 620
Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys
625                 630                 635                 640
Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr
                645                 650                 655
Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe
            660                 665                 670
Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp
        675                 680                 685
Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile
    690                 695                 700
Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro
705                 710                 715                 720
Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln
                725                 730                 735
Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser
            740                 745                 750
Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu
        755                 760                 765
His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe
    770                 775                 780
Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu
785                 790                 795                 800
Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val
                805                 810                 815
Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met
            820                 825                 830
Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly
        835                 840                 845
Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala
    850                 855                 860
Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val
865                 870                 875                 880
Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn
                885                 890                 895
Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn
            900                 905                 910
Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu
        915                 920                 925
Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys
    930                 935                 940
Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala
945                 950                 955                 960
Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met
                965                 970                 975
Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp
            980                 985                 990
Ala Val Asp Gln Ala Lys Val Leu Ala Asn Leu Ala His Pro Pro Ala
        995                 1000                1005
Glu


<210> 1568
<211> 1009
<212> PRT
<213> Homo sapiens

<400> 1568
Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu
 1               5                  10                  15
Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp
            20                  25                  30
Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn
        35                  40                  45
Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln
    50                  55                  60
Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile
65                  70                  75                  80
Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His
                85                  90                  95
Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly
            100                 105                 110
Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg
        115                 120                 125
Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu
    130                 135                 140
Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn
145                 150                 155                 160
Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu
                165                 170                 175
Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His
            180                 185                 190
Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val
        195                 200                 205
Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro
    210                 215                 220
Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser
225                 230                 235                 240
Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly
                245                 250                 255
Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly
            260                 265                 270
Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln
        275                 280                 285
Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln
    290                 295                 300
Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu
305                 310                 315                 320
Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser
                325                 330                 335
Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys
            340                 345                 350
Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys
        355                 360                 365
Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu
    370                 375                 380
Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp
385                 390                 395                 400
Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro
                405                 410                 415
Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly
            420                 425                 430
Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys
        435                 440                 445
Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr
    450                 455                 460
Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn
465                 470                 475                 480
Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu
                485                 490                 495
Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His
            500                 505                 510
Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu
        515                 520                 525
Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn
    530                 535                 540
Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro
545                 550                 555                 560
Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp
                565                 570                 575
Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met
            580                 585                 590
Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val
        595                 600                 605
Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln
    610                 615                 620
Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys
625                 630                 635                 640
Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr
                645                 650                 655
Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe
            660                 665                 670
Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp
        675                 680                 685
Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile
    690                 695                 700
Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro
705                 710                 715                 720
Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln
                725                 730                 735
Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser
            740                 745                 750
Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu
        755                 760                 765
His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe
    770                 775                 780
Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu
785                 790                 795                 800
Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val
                805                 810                 815
Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met
            820                 825                 830
Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly
        835                 840                 845
Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala
    850                 855                 860
Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val
865                 870                 875                 880
Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn
                885                 890                 895
Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn
            900                 905                 910
Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu
        915                 920                 925
Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys
    930                 935                 940
Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala
945                 950                 955                 960
Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met
                965                 970                 975
Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp
            980                 985                 990
Ala Val Asp Gln Ala Lys Val Leu Ala Asn Leu Ala His Pro Pro Ala
        995                 1000                1005
Glu


<210> 1569
<211> 1009
<212> PRT
<213> Homo sapiens

<400> 1569
Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu
 1               5                  10                  15
Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp
            20                  25                  30
Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn
        35                  40                  45
Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln
    50                  55                  60
Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile
65                  70                  75                  80
Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His
                85                  90                  95
Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly
            100                 105                 110
Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg
        115                 120                 125
Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu
    130                 135                 140
Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn
145                 150                 155                 160
Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu
                165                 170                 175
Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His
            180                 185                 190
Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val
        195                 200                 205
Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro
    210                 215                 220
Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser
225                 230                 235                 240
Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly
                245                 250                 255
Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly
            260                 265                 270
Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln
        275                 280                 285
Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln
    290                 295                 300
Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu
305                 310                 315                 320
Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser
                325                 330                 335
Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys
            340                 345                 350
Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys
        355                 360                 365
Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu
    370                 375                 380
Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp
385                 390                 395                 400
Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro
                405                 410                 415
Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly
            420                 425                 430
Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys
        435                 440                 445
Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr
    450                 455                 460
Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn
465                 470                 475                 480
Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu
                485                 490                 495
Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His
            500                 505                 510
Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu
        515                 520                 525
Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn
    530                 535                 540
Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro
545                 550                 555                 560
Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp
                565                 570                 575
Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met
            580                 585                 590
Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val
        595                 600                 605
Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln
    610                 615                 620
Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys
625                 630                 635                 640
Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr
                645                 650                 655
Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe
            660                 665                 670
Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp
        675                 680                 685
Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile
    690                 695                 700
Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro
705                 710                 715                 720
Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln
                725                 730                 735
Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser
            740                 745                 750
Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu
        755                 760                 765
His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe
    770                 775                 780
Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu
785                 790                 795                 800
Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val
                805                 810                 815
Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met
            820                 825                 830
Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly
        835                 840                 845
Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala
    850                 855                 860
Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val
865                 870                 875                 880
Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn
                885                 890                 895
Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn
            900                 905                 910
Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu
        915                 920                 925
Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys
    930                 935                 940
Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala
945                 950                 955                 960
Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met
                965                 970                 975
Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp
            980                 985                 990
Ala Val Asp Gln Ala Lys Val Leu Ala Asn Leu Ala His Pro Pro Ala
        995                 1000                1005
Glu


<210> 1570
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1570
Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His
 1               5                  10                  15
Gln Gln Pro Pro Glu Arg Arg Val Val Thr Val Val Phe Leu Gly Leu
            20                  25                  30
Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly
        35                  40                  45
Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp
    50                  55                  60
Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu
65                  70                  75                  80
Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe
                85                  90                  95
Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp
            100                 105                 110
Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala
        115                 120                 125
Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu
    130                 135                 140
Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser
145                 150                 155                 160
Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly
                165                 170                 175
Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro
            180                 185                 190
Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu
        195                 200                 205
Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu
    210                 215                 220
Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg
225                 230                 235                 240
Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala
                245                 250                 255
Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu
            260                 265                 270
Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly
        275                 280                 285
Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser
    290                 295                 300
Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala
305                 310                 315                 320
Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val
                325                 330                 335
Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu
            340                 345                 350
Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu
        355                 360                 365
Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val
    370                 375                 380
Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu
385                 390                 395                 400
Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala
                405                 410                 415
Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser
            420                 425                 430
Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro
        435                 440                 445
Ala Gln Thr Leu Lys Ala Glu
    450                 455

<210> 1571
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1571
Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His
 1               5                  10                  15
Gln Gln Pro Pro Glu Arg Arg Val Val Thr Val Val Phe Leu Gly Leu
            20                  25                  30
Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly
        35                  40                  45
Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp
    50                  55                  60
Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu
65                  70                  75                  80
Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe
                85                  90                  95
Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp
            100                 105                 110
Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala
        115                 120                 125
Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu
    130                 135                 140
Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser
145                 150                 155                 160
Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly
                165                 170                 175
Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro
            180                 185                 190
Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu
        195                 200                 205
Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu
    210                 215                 220
Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg
225                 230                 235                 240
Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala
                245                 250                 255
Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu
            260                 265                 270
Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly
        275                 280                 285
Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser
    290                 295                 300
Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala
305                 310                 315                 320
Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val
                325                 330                 335
Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu
            340                 345                 350
Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu
        355                 360                 365
Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val
    370                 375                 380
Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu
385                 390                 395                 400
Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala
                405                 410                 415
Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser
            420                 425                 430
Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro
        435                 440                 445
Ala Gln Thr Leu Lys Ala Glu
    450                 455

<210> 1572
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1572
Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His
 1               5                  10                  15
Gln Gln Pro Pro Glu Arg Arg Val Val Thr Val Val Phe Leu Gly Leu
            20                  25                  30
Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly
        35                  40                  45
Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp
    50                  55                  60
Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu
65                  70                  75                  80
Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe
                85                  90                  95
Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp
            100                 105                 110
Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala
        115                 120                 125
Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu
    130                 135                 140
Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser
145                 150                 155                 160
Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly
                165                 170                 175
Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro
            180                 185                 190
Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu
        195                 200                 205
Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu
    210                 215                 220
Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg
225                 230                 235                 240
Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala
                245                 250                 255
Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu
            260                 265                 270
Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly
        275                 280                 285
Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser
    290                 295                 300
Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala
305                 310                 315                 320
Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val
                325                 330                 335
Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu
            340                 345                 350
Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu
        355                 360                 365
Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val
    370                 375                 380
Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu
385                 390                 395                 400
Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala
                405                 410                 415
Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser
            420                 425                 430
Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro
        435                 440                 445
Ala Gln Thr Leu Lys Ala Glu
    450                 455

<210> 1573
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1573
Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His
 1               5                  10                  15
Gln Gln Pro Pro Glu Arg Arg Val Val Ile Val Val Phe Leu Gly Leu
            20                  25                  30
Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly
        35                  40                  45
Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp
    50                  55                  60
Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu
65                  70                  75                  80
Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe
                85                  90                  95
Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp
            100                 105                 110
Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala
        115                 120                 125
Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu
    130                 135                 140
Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser
145                 150                 155                 160
Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly
                165                 170                 175
Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro
            180                 185                 190
Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu
        195                 200                 205
Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu
    210                 215                 220
Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg
225                 230                 235                 240
Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala
                245                 250                 255
Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu
            260                 265                 270
Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly
        275                 280                 285
Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser
    290                 295                 300
Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala
305                 310                 315                 320
Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val
                325                 330                 335
Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu
            340                 345                 350
Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu
        355                 360                 365
Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val
    370                 375                 380
Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu
385                 390                 395                 400
Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala
                405                 410                 415
Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser
            420                 425                 430
Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro
        435                 440                 445
Ala Gln Thr Leu Lys Ala Glu
    450                 455

<210> 1574
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1574
Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His
 1               5                  10                  15
Gln Gln Pro Pro Glu Arg Arg Val Val Ile Val Val Phe Leu Gly Leu
            20                  25                  30
Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly
        35                  40                  45
Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp
    50                  55                  60
Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu
65                  70                  75                  80
Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe
                85                  90                  95
Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp
            100                 105                 110
Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala
        115                 120                 125
Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu
    130                 135                 140
Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser
145                 150                 155                 160
Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly
                165                 170                 175
Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro
            180                 185                 190
Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu
        195                 200                 205
Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu
    210                 215                 220
Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg
225                 230                 235                 240
Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala
                245                 250                 255
Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu
            260                 265                 270
Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly
        275                 280                 285
Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser
    290                 295                 300
Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala
305                 310                 315                 320
Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val
                325                 330                 335
Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu
            340                 345                 350
Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu
        355                 360                 365
Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val
    370                 375                 380
Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu
385                 390                 395                 400
Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala
                405                 410                 415
Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser
            420                 425                 430
Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro
        435                 440                 445
Ala Gln Thr Leu Lys Ala Glu
    450                 455

<210> 1575
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1575
Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His
 1               5                  10                  15
Gln Gln Pro Pro Glu Arg Arg Val Val Thr Val Val Phe Leu Gly Leu
            20                  25                  30
Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly
        35                  40                  45
Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp
    50                  55                  60
Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu
65                  70                  75                  80
Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe
                85                  90                  95
Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp
            100                 105                 110
Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala
        115                 120                 125
Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu
    130                 135                 140
Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser
145                 150                 155                 160
Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly
                165                 170                 175
Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro
            180                 185                 190
Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu
        195                 200                 205
Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu
    210                 215                 220
Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg
225                 230                 235                 240
Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala
                245                 250                 255
Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu
            260                 265                 270
Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly
        275                 280                 285
Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser
    290                 295                 300
Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala
305                 310                 315                 320
Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val
                325                 330                 335
Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu
            340                 345                 350
Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu
        355                 360                 365
Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val
    370                 375                 380
Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu
385                 390                 395                 400
Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala
                405                 410                 415
Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser
            420                 425                 430
Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro
        435                 440                 445
Ala Gln Thr Leu Lys Ala Glu
    450                 455

<210> 1576
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1576
Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His
 1               5                  10                  15
Gln Gln Pro Pro Glu Arg Arg Val Val Ile Val Val Phe Leu Gly Leu
            20                  25                  30
Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly
        35                  40                  45
Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp
    50                  55                  60
Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu
65                  70                  75                  80
Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe
                85                  90                  95
Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp
            100                 105                 110
Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala
        115                 120                 125
Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu
    130                 135                 140
Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser
145                 150                 155                 160
Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly
                165                 170                 175
Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro
            180                 185                 190
Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu
        195                 200                 205
Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu
    210                 215                 220
Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg
225                 230                 235                 240
Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala
                245                 250                 255
Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu
            260                 265                 270
Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly
        275                 280                 285
Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser
    290                 295                 300
Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala
305                 310                 315                 320
Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val
                325                 330                 335
Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu
            340                 345                 350
Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu
        355                 360                 365
Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val
    370                 375                 380
Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu
385                 390                 395                 400
Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala
                405                 410                 415
Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser
            420                 425                 430
Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro
        435                 440                 445
Ala Gln Thr Leu Lys Ala Glu
    450                 455

<210> 1577
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1577
Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His
 1               5                  10                  15
Gln Gln Pro Pro Glu Arg Arg Val Val Thr Val Val Phe Leu Gly Leu
            20                  25                  30
Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly
        35                  40                  45
Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp
    50                  55                  60
Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu
65                  70                  75                  80
Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe
                85                  90                  95
Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp
            100                 105                 110
Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala
        115                 120                 125
Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu
    130                 135                 140
Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser
145                 150                 155                 160
Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly
                165                 170                 175
Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro
            180                 185                 190
Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu
        195                 200                 205
Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu
    210                 215                 220
Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg
225                 230                 235                 240
Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala
                245                 250                 255
Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu
            260                 265                 270
Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly
        275                 280                 285
Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser
    290                 295                 300
Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala
305                 310                 315                 320
Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val
                325                 330                 335
Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu
            340                 345                 350
Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu
        355                 360                 365
Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val
    370                 375                 380
Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu
385                 390                 395                 400
Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala
                405                 410                 415
Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser
            420                 425                 430
Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro
        435                 440                 445
Ala Gln Thr Leu Lys Ala Glu
    450                 455

<210> 1578
<211> 435
<212> PRT
<213> Homo sapiens

<400> 1578
Met Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val Lys Pro
 1               5                  10                  15
Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val Gly Ile
            20                  25                  30
Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val
        35                  40                  45
Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln
    50                  55                  60
Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp
65                  70                  75                  80
Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu
                85                  90                  95
Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln
            100                 105                 110
Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn
        115                 120                 125
Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly Tyr Ser
    130                 135                 140
Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu
145                 150                 155                 160
Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn
                165                 170                 175
Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu
            180                 185                 190
Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly Glu Glu
        195                 200                 205
Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys
    210                 215                 220
Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr
225                 230                 235                 240
Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val
                245                 250                 255
Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala
            260                 265                 270
Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp
        275                 280                 285
Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val
    290                 295                 300
Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr
305                 310                 315                 320
Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys
                325                 330                 335
Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr
            340                 345                 350
Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met
        355                 360                 365
Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp
    370                 375                 380
Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly
385                 390                 395                 400
Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val
                405                 410                 415
Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys
            420                 425                 430
Ala Glu Leu
        435

<210> 1579
<211> 492
<212> PRT
<213> Homo sapiens

<400> 1579
Met Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val Lys Pro
 1               5                  10                  15
Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val Gly Ile
            20                  25                  30
Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val
        35                  40                  45
Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln
    50                  55                  60
Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp
65                  70                  75                  80
Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu
                85                  90                  95
Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln
            100                 105                 110
Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn
        115                 120                 125
Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly Tyr Ser
    130                 135                 140
Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu
145                 150                 155                 160
Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn
                165                 170                 175
Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu
            180                 185                 190
Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly Glu Glu
        195                 200                 205
Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys
    210                 215                 220
Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr
225                 230                 235                 240
Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val
                245                 250                 255
Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala
            260                 265                 270
Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp
        275                 280                 285
Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val
    290                 295                 300
Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr
305                 310                 315                 320
Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys
                325                 330                 335
Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr
            340                 345                 350
Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met
        355                 360                 365
Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp
    370                 375                 380
Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly
385                 390                 395                 400
Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val
                405                 410                 415
Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys
            420                 425                 430
Asp Arg Thr Ile Gln Arg Ser Cys Asn Ser Pro Gly Thr Gly Leu Val
        435                 440                 445
Ile Gln Gln Pro Ala Val Pro Leu Met Glu Leu Arg Ser Ala Arg His
    450                 455                 460
Thr His Arg Leu Thr Thr Cys Val Cys Phe Leu Ser Phe Pro Ala Leu
465                 470                 475                 480
Gln Pro Leu Ser Pro Leu Cys Pro Phe Pro Trp Asp
                485                 490

<210> 1580
<211> 203
<212> PRT
<213> Homo sapiens

<400> 1580
Met Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val Lys Pro
 1               5                  10                  15
Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val Gly Ile
            20                  25                  30
Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val
        35                  40                  45
Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln
    50                  55                  60
Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp
65                  70                  75                  80
Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu
                85                  90                  95
Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln
            100                 105                 110
Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn
        115                 120                 125
Phe Thr Ala Ala Leu Ala Arg Pro His Leu Val Leu Pro Ala Ser Gln
    130                 135                 140
Gly Glu Thr Gln Pro Thr Glu Gln Gly Leu Arg Gly Ile Ala Lys Pro
145                 150                 155                 160
Arg Arg Asn Phe Pro Thr Leu Leu Asn Gly Ser Arg Leu Ser Cys Lys
                165                 170                 175
Ser Pro Asp His Cys Gly Leu Glu Arg Arg Arg Lys Gly Ser Ala Pro
            180                 185                 190
Ala Leu Ser Val Phe Thr His Pro Gln Ala Tyr
        195                 200

<210> 1581
<211> 437
<212> PRT
<213> Homo sapiens

<400> 1581
Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val
            20                  25                  30
Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
        35                  40                  45
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
    50                  55                  60
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
65                  70                  75                  80
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
                85                  90                  95
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
            100                 105                 110
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
        115                 120                 125
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
    130                 135                 140
Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln
145                 150                 155                 160
Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met
                165                 170                 175
Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His
            180                 185                 190
Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly
        195                 200                 205
Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr
    210                 215                 220
Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val
225                 230                 235                 240
Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp
                245                 250                 255
Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala
            260                 265                 270
Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp
        275                 280                 285
Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly
    290                 295                 300
Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro
305                 310                 315                 320
Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly
                325                 330                 335
Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp
            340                 345                 350
Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu
        355                 360                 365
Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln
    370                 375                 380
Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val
385                 390                 395                 400
Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro
                405                 410                 415
Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val
            420                 425                 430
Trp Lys Ala Glu Leu
        435

<210> 1582
<211> 405
<212> PRT
<213> Homo sapiens

<400> 1582
Ala Arg Gly Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
 1               5                  10                  15
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
            20                  25                  30
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
        35                  40                  45
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
    50                  55                  60
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
65                  70                  75                  80
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
                85                  90                  95
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
            100                 105                 110
Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln
        115                 120                 125
Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met
    130                 135                 140
Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His
145                 150                 155                 160
Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly
                165                 170                 175
Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr
            180                 185                 190
Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val
        195                 200                 205
Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp
    210                 215                 220
Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala
225                 230                 235                 240
Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp
                245                 250                 255
Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly
            260                 265                 270
Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro
        275                 280                 285
Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly
    290                 295                 300
Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp
305                 310                 315                 320
Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu
                325                 330                 335
Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln
            340                 345                 350
Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val
        355                 360                 365
Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro
    370                 375                 380
Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val
385                 390                 395                 400
Trp Lys Ala Glu Leu
                405

<210> 1583
<211> 437
<212> PRT
<213> Homo sapiens

<400> 1583
Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val
            20                  25                  30
Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
        35                  40                  45
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
    50                  55                  60
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
65                  70                  75                  80
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
                85                  90                  95
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
            100                 105                 110
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
        115                 120                 125
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
    130                 135                 140
Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln
145                 150                 155                 160
Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met
                165                 170                 175
Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His
            180                 185                 190
Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly
        195                 200                 205
Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr
    210                 215                 220
Asp Ile Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val
225                 230                 235                 240
Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp
                245                 250                 255
Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala
            260                 265                 270
Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp
        275                 280                 285
Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly
    290                 295                 300
Thr Val Arg Leu Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro
305                 310                 315                 320
Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly
                325                 330                 335
Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp
            340                 345                 350
Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu
        355                 360                 365
Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln
    370                 375                 380
Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val
385                 390                 395                 400
Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro
                405                 410                 415
Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val
            420                 425                 430
Trp Lys Ala Glu Leu
        435

<210> 1584
<211> 423
<212> PRT
<213> Homo sapiens

<400> 1584
Met Ser Asn Pro Cys Ala Asn Pro Val Ser Pro Trp Arg Pro Ser Glu
 1               5                  10                  15
Ser Val Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile
            20                  25                  30
Ile Ile Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe
        35                  40                  45
Leu Cys Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp
    50                  55                  60
Gly Glu Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys
65                  70                  75                  80
Ser Phe Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg
                85                  90                  95
Ser Thr Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala
            100                 105                 110
Cys Phe Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln
        115                 120                 125
Met Gly Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro
    130                 135                 140
Asp Gln Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu
145                 150                 155                 160
Arg Met Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser
                165                 170                 175
Leu His Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val
            180                 185                 190
Gly Gly Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile
        195                 200                 205
Gln Tyr Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His
    210                 215                 220
Trp Val Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe
225                 230                 235                 240
Asn Trp Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser
                245                 250                 255
Leu Ala Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro
            260                 265                 270
Lys Asp Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe
        275                 280                 285
Ser Gly Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu
    290                 295                 300
Thr Pro Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln
305                 310                 315                 320
Asn Gly Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val
                325                 330                 335
Ile Asp Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val
            340                 345                 350
Thr Glu Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr
        355                 360                 365
Cys Gln Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp
    370                 375                 380
His Val Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser
385                 390                 395                 400
Thr Pro Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr
                405                 410                 415
Asn Val Trp Lys Ala Glu Leu
            420

<210> 1585
<211> 423
<212> PRT
<213> Homo sapiens

<400> 1585
Met Ser Asn Pro Cys Ala Asn Pro Val Ser Pro Trp Arg Pro Ser Glu
 1               5                  10                  15
Ser Val Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile
            20                  25                  30
Ile Ile Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe
        35                  40                  45
Leu Cys Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp
    50                  55                  60
Gly Glu Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys
65                  70                  75                  80
Ser Phe Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg
                85                  90                  95
Ser Thr Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala
            100                 105                 110
Cys Phe Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln
        115                 120                 125
Met Gly Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro
    130                 135                 140
Asp Gln Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu
145                 150                 155                 160
Arg Met Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser
                165                 170                 175
Leu His Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val
            180                 185                 190
Gly Gly Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile
        195                 200                 205
Gln Tyr Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His
    210                 215                 220
Trp Val Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe
225                 230                 235                 240
Asn Trp Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser
                245                 250                 255
Leu Ala Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro
            260                 265                 270
Lys Asp Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe
        275                 280                 285
Ser Gly Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu
    290                 295                 300
Thr Pro Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln
305                 310                 315                 320
Asn Gly Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val
                325                 330                 335
Ile Asp Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val
            340                 345                 350
Thr Glu Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr
        355                 360                 365
Cys Gln Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp
    370                 375                 380
His Val Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser
385                 390                 395                 400
Thr Pro Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr
                405                 410                 415
Asn Val Trp Lys Ala Glu Leu
            420

<210> 1586
<211> 437
<212> PRT
<213> Homo sapiens

<400> 1586
Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val
            20                  25                  30
Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
        35                  40                  45
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
    50                  55                  60
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
65                  70                  75                  80
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
                85                  90                  95
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
            100                 105                 110
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
        115                 120                 125
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
    130                 135                 140
Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln
145                 150                 155                 160
Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met
                165                 170                 175
Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His
            180                 185                 190
Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly
        195                 200                 205
Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr
    210                 215                 220
Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val
225                 230                 235                 240
Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp
                245                 250                 255
Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala
            260                 265                 270
Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp
        275                 280                 285
Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly
    290                 295                 300
Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro
305                 310                 315                 320
Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly
                325                 330                 335
Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp
            340                 345                 350
Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu
        355                 360                 365
Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln
    370                 375                 380
Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val
385                 390                 395                 400
Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro
                405                 410                 415
Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val
            420                 425                 430
Trp Lys Ala Glu Leu
        435

<210> 1587
<211> 432
<212> PRT
<213> Homo sapiens

<400> 1587
Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val
            20                  25                  30
Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
        35                  40                  45
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
    50                  55                  60
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
65                  70                  75                  80
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
                85                  90                  95
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
            100                 105                 110
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
        115                 120                 125
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
    130                 135                 140
Tyr Ser Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu Asp Val Val
145                 150                 155                 160
Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn Ser Ser Gly
                165                 170                 175
Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu Ala Cys Gly
            180                 185                 190
Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly Glu Glu Ala Ser Val
        195                 200                 205
Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys Gln His Val
    210                 215                 220
Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr Ala Ala His
225                 230                 235                 240
Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val Arg Ala Gly
                245                 250                 255
Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala Lys Ile Ile
            260                 265                 270
Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp Ile Ala Leu
        275                 280                 285
Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val Arg Pro Ile
    290                 295                 300
Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr Pro Leu Trp
305                 310                 315                 320
Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys Met Ser Asp
                325                 330                 335
Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr Arg Cys Asn
            340                 345                 350
Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met Met Cys Ala
        355                 360                 365
Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp Ser Gly Gly
    370                 375                 380
Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly Ile Val Ser
385                 390                 395                 400
Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val Tyr Thr Lys
                405                 410                 415
Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys Ala Glu Leu
            420                 425                 430

<210> 1588
<211> 437
<212> PRT
<213> Homo sapiens

<400> 1588
Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val
            20                  25                  30
Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
        35                  40                  45
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
    50                  55                  60
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
65                  70                  75                  80
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
                85                  90                  95
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
            100                 105                 110
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
        115                 120                 125
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
    130                 135                 140
Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln
145                 150                 155                 160
Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met
                165                 170                 175
Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His
            180                 185                 190
Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly
        195                 200                 205
Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr
    210                 215                 220
Asp Ile Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val
225                 230                 235                 240
Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp
                245                 250                 255
Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala
            260                 265                 270
Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp
        275                 280                 285
Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly
    290                 295                 300
Thr Val Arg Leu Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro
305                 310                 315                 320
Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly
                325                 330                 335
Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp
            340                 345                 350
Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu
        355                 360                 365
Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln
    370                 375                 380
Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val
385                 390                 395                 400
Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro
                405                 410                 415
Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val
            420                 425                 430
Trp Lys Ala Glu Leu
        435

<210> 1589
<211> 423
<212> PRT
<213> Homo sapiens

<400> 1589
Met Ser Asn Pro Cys Ala Asn Pro Val Ser Pro Trp Arg Pro Ser Glu
 1               5                  10                  15
Ser Val Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile
            20                  25                  30
Ile Ile Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe
        35                  40                  45
Leu Cys Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp
    50                  55                  60
Gly Glu Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys
65                  70                  75                  80
Ser Phe Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg
                85                  90                  95
Ser Thr Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala
            100                 105                 110
Cys Phe Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln
        115                 120                 125
Met Gly Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro
    130                 135                 140
Asp Gln Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu
145                 150                 155                 160
Arg Met Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser
                165                 170                 175
Leu His Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val
            180                 185                 190
Gly Gly Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile
        195                 200                 205
Gln Tyr Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His
    210                 215                 220
Trp Val Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe
225                 230                 235                 240
Asn Trp Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser
                245                 250                 255
Leu Ala Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro
            260                 265                 270
Lys Asp Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe
        275                 280                 285
Ser Gly Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu
    290                 295                 300
Thr Pro Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln
305                 310                 315                 320
Asn Gly Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val
                325                 330                 335
Ile Asp Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val
            340                 345                 350
Thr Glu Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr
        355                 360                 365
Cys Gln Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp
    370                 375                 380
His Val Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser
385                 390                 395                 400
Thr Pro Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr
                405                 410                 415
Asn Val Trp Lys Ala Glu Leu
            420

<210> 1590
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(216)
<223> Xaa = Any Amino Acid

<400> 1590
Ala Ser Met Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Ile Ile Ile Ala Leu Leu Ser
            20                  25                  30
Leu Ala Ser Ile Ile Ile Val Val Val Leu Ile Lys Val Ile Leu Asp
        35                  40                  45
Lys Tyr Tyr Phe Leu Cys Gly Gln Pro Leu His Phe Ile Pro Arg Lys
    50                  55                  60
Gln Leu Cys Asp Gly Glu Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu
65                  70                  75                  80
His Cys Val Lys Ser Phe Pro Glu Gly Pro Xaa Val Ala Val Arg Leu
                85                  90                  95
Ser Lys Asp Arg Ser Thr Leu Gln Val Leu Asp Ser Ala Thr Gly Asn
            100                 105                 110
Trp Phe Ser Ala Cys Phe Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr
        115                 120                 125
Ala Cys Arg Gln Met Gly Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val
    130                 135                 140
Glu Ile Gly Pro Asp Gln Asp Leu Asp Val Val Glu Ile Thr Glu Asn
145                 150                 155                 160
Ser Gln Glu Leu Arg Met Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly
                165                 170                 175
Ser Leu Val Ser Leu His Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr
            180                 185                 190
Pro Arg Val Val Xaa Gly Glu Glu Ala Ser Val Asp Ser Trp Pro Trp
        195                 200                 205
Gln Val Ser Ile Gln Tyr Xaa Lys
    210                 215

<210> 1591
<211> 521
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(521)
<223> Xaa = Any Amino Acid

<400> 1591
Pro Gly Thr Ser Asp Leu Leu Ala Ser Gln Asp Leu Cys Gly Glu Ala
 1               5                  10                  15
Leu Leu Leu Pro Trp Gly Asp Asn Leu Ser Ser Arg Leu Gln Gly Asp
            20                  25                  30
Arg Glu Asp His Arg Ala Ser Met Asp Pro Asp Ser Asp Gln Pro Leu
        35                  40                  45
Asn Ser Leu Asp Val Lys Pro Leu Arg Lys Pro Arg Ile Pro Ile Ile
    50                  55                  60
Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val Val Leu Ile
65                  70                  75                  80
Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln Pro Leu His
                85                  90                  95
Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp Cys Pro Leu
            100                 105                 110
Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu Gly Pro Xaa
        115                 120                 125
Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln Val Leu Asp
    130                 135                 140
Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn Phe Thr Glu
145                 150                 155                 160
Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly Tyr Ser Ser Lys Pro
                165                 170                 175
Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu Asp Val Val
            180                 185                 190
Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn Ser Ser Gly
        195                 200                 205
Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu Ala Cys Gly
    210                 215                 220
Lys Ser Leu Lys Thr Pro Arg Val Val Xaa Gly Glu Glu Ala Ser Val
225                 230                 235                 240
Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys Gln His Val
                245                 250                 255
Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr Ala Ala His
            260                 265                 270
Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val Arg Ala Gly
        275                 280                 285
Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala Lys Ile Ile
    290                 295                 300
Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp Ile Ala Leu
305                 310                 315                 320
Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val Arg Pro Ile
                325                 330                 335
Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr Pro Leu Trp
            340                 345                 350
Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys Met Ser Asp
        355                 360                 365
Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr Arg Cys Asn
    370                 375                 380
Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met Met Cys Ala
385                 390                 395                 400
Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp Ser Gly Gly
                405                 410                 415
Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly Ile Val Ser
            420                 425                 430
Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val Tyr Thr Lys
        435                 440                 445
Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys Asp Arg Thr
    450                 455                 460
Ile Gln Arg Ser Cys Asn Ser Pro Gly Thr Gly Leu Val Ile Gln Gln
465                 470                 475                 480
Pro Ala Val Pro Leu Met Glu Leu Arg Ser Ala Arg His Thr His Arg
                485                 490                 495
Leu Thr Thr Cys Val Cys Phe Leu Ser Phe Pro Ala Leu Gln Pro Leu
            500                 505                 510
Ser Pro Leu Cys Pro Phe Pro Trp Asp
        515                 520

<210> 1592
<211> 257
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(257)
<223> Xaa = Any Amino Acid

<400> 1592
Pro Gly Thr Ser Asp Leu Leu Ala Ser Gln Asp Leu Cys Gly Glu Ala
 1               5                  10                  15
Leu Leu Leu Pro Trp Gly Asp Asn Leu Ser Ser Arg Leu Gln Gly Asp
            20                  25                  30
Arg Glu Asp His Arg Ala Ser Met Asp Pro Asp Ser Asp Gln Pro Leu
        35                  40                  45
Asn Ser Leu Asp Val Lys Pro Leu Arg Lys Pro Arg Ile Pro Ile Ile
    50                  55                  60
Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val Val Leu Ile
65                  70                  75                  80
Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln Pro Leu His
                85                  90                  95
Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp Cys Pro Leu
            100                 105                 110
Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu Gly Pro Ala
        115                 120                 125
Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln Val Leu Asp
    130                 135                 140
Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn Phe Thr Glu
145                 150                 155                 160
Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly Tyr Ser Ser Lys Pro
                165                 170                 175
Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu Asp Val Val
            180                 185                 190
Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn Ser Ser Gly
        195                 200                 205
Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu Ala Cys Gly
    210                 215                 220
Lys Ser Leu Lys Thr Pro Arg Val Val Xaa Gly Glu Glu Ala Ser Val
225                 230                 235                 240
Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Ser Thr Asn Lys His Cys
                245                 250                 255
Leu


<210> 1593
<211> 257
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(257)
<223> Xaa = Any Amino Acid

<400> 1593
Pro Gly Thr Ser Asp Leu Leu Ala Ser Gln Asp Leu Cys Gly Glu Ala
 1               5                  10                  15
Leu Leu Leu Pro Trp Gly Asp Asn Leu Ser Ser Arg Leu Gln Gly Asp
            20                  25                  30
Arg Glu Asp His Arg Ala Ser Met Asp Pro Asp Ser Asp Gln Pro Leu
        35                  40                  45
Asn Ser Leu Asp Val Lys Pro Leu Arg Lys Pro Arg Ile Pro Ile Ile
    50                  55                  60
Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val Val Leu Ile
65                  70                  75                  80
Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln Pro Leu His
                85                  90                  95
Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp Cys Pro Leu
            100                 105                 110
Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu Gly Pro Ala
        115                 120                 125
Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln Val Leu Asp
    130                 135                 140
Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn Phe Thr Glu
145                 150                 155                 160
Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly Tyr Ser Ser Lys Pro
                165                 170                 175
Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu Asp Val Val
            180                 185                 190
Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn Ser Ser Gly
        195                 200                 205
Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu Ala Cys Gly
    210                 215                 220
Lys Ser Leu Lys Thr Pro Arg Val Val Xaa Gly Glu Glu Ala Ser Val
225                 230                 235                 240
Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Ser Thr Asn Lys His Cys
                245                 250                 255
Leu


<210> 1594
<211> 257
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(257)
<223> Xaa = Any Amino Acid

<400> 1594
Pro Gly Thr Ser Asp Leu Leu Ala Ser Gln Asp Leu Cys Gly Glu Ala
 1               5                  10                  15
Leu Leu Leu Pro Trp Gly Asp Asn Leu Ser Ser Arg Leu Gln Gly Asp
            20                  25                  30
Arg Glu Asp His Arg Ala Ser Met Asp Pro Asp Ser Asp Gln Pro Leu
        35                  40                  45
Asn Ser Leu Asp Val Lys Pro Leu Arg Lys Pro Arg Ile Pro Ile Ile
    50                  55                  60
Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val Val Leu Ile
65                  70                  75                  80
Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln Pro Leu His
                85                  90                  95
Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp Cys Pro Leu
            100                 105                 110
Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu Gly Pro Ala
        115                 120                 125
Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln Val Leu Asp
    130                 135                 140
Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn Phe Thr Glu
145                 150                 155                 160
Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly Tyr Ser Ser Lys Pro
                165                 170                 175
Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu Asp Val Val
            180                 185                 190
Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn Ser Ser Gly
        195                 200                 205
Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu Ala Cys Gly
    210                 215                 220
Lys Ser Leu Lys Thr Pro Arg Val Val Xaa Gly Glu Glu Ala Ser Val
225                 230                 235                 240
Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Ser Thr Asn Lys His Cys
                245                 250                 255
Leu


<210> 1595
<211> 432
<212> PRT
<213> Homo sapiens

<400> 1595
Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val
            20                  25                  30
Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
        35                  40                  45
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
    50                  55                  60
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
65                  70                  75                  80
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
                85                  90                  95
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
            100                 105                 110
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
        115                 120                 125
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
    130                 135                 140
Tyr Ser Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu Asp Val Val
145                 150                 155                 160
Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn Ser Ser Gly
                165                 170                 175
Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu Ala Cys Gly
            180                 185                 190
Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly Glu Glu Ala Ser Val
        195                 200                 205
Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys Gln His Val
    210                 215                 220
Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr Ala Ala His
225                 230                 235                 240
Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val Arg Ala Gly
                245                 250                 255
Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala Lys Ile Ile
            260                 265                 270
Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp Ile Ala Leu
        275                 280                 285
Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val Arg Pro Ile
    290                 295                 300
Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr Pro Leu Trp
305                 310                 315                 320
Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys Met Ser Asp
                325                 330                 335
Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr Arg Cys Asn
            340                 345                 350
Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met Met Cys Ala
        355                 360                 365
Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp Ser Gly Gly
    370                 375                 380
Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly Ile Val Ser
385                 390                 395                 400
Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val Tyr Thr Lys
                405                 410                 415
Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys Ala Glu Leu
            420                 425                 430

<210> 1596
<211> 435
<212> PRT
<213> Homo sapiens

<400> 1596
Met Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val Lys Pro
 1               5                  10                  15
Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val Gly Ile
            20                  25                  30
Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val
        35                  40                  45
Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln
    50                  55                  60
Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp
65                  70                  75                  80
Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu
                85                  90                  95
Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln
            100                 105                 110
Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn
        115                 120                 125
Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly Tyr Ser
    130                 135                 140
Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu
145                 150                 155                 160
Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn
                165                 170                 175
Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu
            180                 185                 190
Ala Cys Gly Glu Ser Leu Lys Thr Pro Arg Val Val Gly Gly Glu Glu
        195                 200                 205
Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys
    210                 215                 220
Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr
225                 230                 235                 240
Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val
                245                 250                 255
Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala
            260                 265                 270
Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp
        275                 280                 285
Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val
    290                 295                 300
Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr
305                 310                 315                 320
Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys
                325                 330                 335
Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr
            340                 345                 350
Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met
        355                 360                 365
Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp
    370                 375                 380
Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly
385                 390                 395                 400
Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val
                405                 410                 415
Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys
            420                 425                 430
Ala Glu Leu
        435

<210> 1597
<211> 435
<212> PRT
<213> Homo sapiens

<400> 1597
Met Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val Lys Pro
 1               5                  10                  15
Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val Gly Ile
            20                  25                  30
Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val
        35                  40                  45
Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln
    50                  55                  60
Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp
65                  70                  75                  80
Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu
                85                  90                  95
Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln
            100                 105                 110
Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn
        115                 120                 125
Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly Tyr Ser
    130                 135                 140
Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu
145                 150                 155                 160
Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn
                165                 170                 175
Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu
            180                 185                 190
Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly Glu Glu
        195                 200                 205
Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys
    210                 215                 220
Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr
225                 230                 235                 240
Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val
                245                 250                 255
Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala
            260                 265                 270
Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp
        275                 280                 285
Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val
    290                 295                 300
Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr
305                 310                 315                 320
Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys
                325                 330                 335
Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr
            340                 345                 350
Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met
        355                 360                 365
Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp
    370                 375                 380
Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly
385                 390                 395                 400
Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val
                405                 410                 415
Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys
            420                 425                 430
Ala Glu Leu
        435

<210> 1598
<211> 492
<212> PRT
<213> Homo sapiens

<400> 1598
Met Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val Lys Pro
 1               5                  10                  15
Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val Gly Ile
            20                  25                  30
Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val
        35                  40                  45
Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln
    50                  55                  60
Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp
65                  70                  75                  80
Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu
                85                  90                  95
Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln
            100                 105                 110
Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn
        115                 120                 125
Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly Tyr Ser
    130                 135                 140
Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu
145                 150                 155                 160
Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn
                165                 170                 175
Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu
            180                 185                 190
Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly Glu Glu
        195                 200                 205
Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys
    210                 215                 220
Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr
225                 230                 235                 240
Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val
                245                 250                 255
Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala
            260                 265                 270
Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp
        275                 280                 285
Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val
    290                 295                 300
Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr
305                 310                 315                 320
Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys
                325                 330                 335
Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr
            340                 345                 350
Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met
        355                 360                 365
Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp
    370                 375                 380
Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly
385                 390                 395                 400
Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val
                405                 410                 415
Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys
            420                 425                 430
Asp Arg Thr Ile Gln Arg Ser Cys Asn Ser Pro Gly Thr Gly Leu Val
        435                 440                 445
Ile Gln Gln Pro Ala Val Pro Leu Met Glu Leu Arg Ser Ala Arg His
    450                 455                 460
Thr His Arg Leu Thr Thr Cys Val Cys Phe Leu Ser Phe Pro Ala Leu
465                 470                 475                 480
Gln Pro Leu Ser Pro Leu Cys Pro Phe Pro Trp Asp
                485                 490

<210> 1599
<211> 203
<212> PRT
<213> Homo sapiens

<400> 1599
Met Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val Lys Pro
 1               5                  10                  15
Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val Gly Ile
            20                  25                  30
Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile Val Val
        35                  40                  45
Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys Gly Gln
    50                  55                  60
Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu Leu Asp
65                  70                  75                  80
Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe Pro Glu
                85                  90                  95
Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr Leu Gln
            100                 105                 110
Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe Asp Asn
        115                 120                 125
Phe Thr Ala Ala Leu Ala Arg Pro His Leu Val Leu Pro Ala Ser Gln
    130                 135                 140
Gly Glu Thr Gln Pro Thr Glu Gln Gly Leu Arg Gly Ile Ala Lys Pro
145                 150                 155                 160
Arg Arg Asn Phe Pro Thr Leu Leu Asn Gly Ser Arg Leu Ser Cys Lys
                165                 170                 175
Ser Pro Asp His Cys Gly Leu Glu Arg Arg Arg Lys Gly Ser Ala Pro
            180                 185                 190
Ala Leu Ser Val Phe Thr His Pro Gln Ala Tyr
        195                 200

<210> 1600
<211> 432
<212> PRT
<213> Homo sapiens

<400> 1600
Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val
            20                  25                  30
Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
        35                  40                  45
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
    50                  55                  60
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
65                  70                  75                  80
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
                85                  90                  95
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
            100                 105                 110
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
        115                 120                 125
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
    130                 135                 140
Tyr Ser Arg Ala Val Glu Ile Gly Pro Asp Gln Asp Leu Asp Val Val
145                 150                 155                 160
Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met Arg Asn Ser Ser Gly
                165                 170                 175
Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His Cys Leu Ala Cys Gly
            180                 185                 190
Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly Glu Glu Ala Ser Val
        195                 200                 205
Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr Asp Lys Gln His Val
    210                 215                 220
Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val Leu Thr Ala Ala His
225                 230                 235                 240
Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp Lys Val Arg Ala Gly
                245                 250                 255
Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala Val Ala Lys Ile Ile
            260                 265                 270
Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp Asn Asp Ile Ala Leu
        275                 280                 285
Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly Thr Val Arg Pro Ile
    290                 295                 300
Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro Ala Thr Pro Leu Trp
305                 310                 315                 320
Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly Gly Lys Met Ser Asp
                325                 330                 335
Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp Ser Thr Arg Cys Asn
            340                 345                 350
Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu Lys Met Met Cys Ala
        355                 360                 365
Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln Gly Asp Ser Gly Gly
    370                 375                 380
Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val Val Gly Ile Val Ser
385                 390                 395                 400
Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro Gly Val Tyr Thr Lys
                405                 410                 415
Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val Trp Lys Ala Glu Leu
            420                 425                 430

<210> 1601
<211> 437
<212> PRT
<213> Homo sapiens

<400> 1601
Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val
            20                  25                  30
Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
        35                  40                  45
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
    50                  55                  60
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
65                  70                  75                  80
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
                85                  90                  95
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
            100                 105                 110
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
        115                 120                 125
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
    130                 135                 140
Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln
145                 150                 155                 160
Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met
                165                 170                 175
Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His
            180                 185                 190
Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly
        195                 200                 205
Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr
    210                 215                 220
Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val
225                 230                 235                 240
Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp
                245                 250                 255
Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala
            260                 265                 270
Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp
        275                 280                 285
Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly
    290                 295                 300
Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro
305                 310                 315                 320
Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly
                325                 330                 335
Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp
            340                 345                 350
Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu
        355                 360                 365
Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln
    370                 375                 380
Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val
385                 390                 395                 400
Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro
                405                 410                 415
Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val
            420                 425                 430
Trp Lys Ala Glu Leu
        435

<210> 1602
<211> 437
<212> PRT
<213> Homo sapiens

<400> 1602
Met Leu Gln Asp Pro Asp Ser Asp Gln Pro Leu Asn Ser Leu Asp Val
 1               5                  10                  15
Lys Pro Leu Arg Lys Pro Arg Ile Pro Met Glu Thr Phe Arg Lys Val
            20                  25                  30
Gly Ile Pro Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
        35                  40                  45
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
    50                  55                  60
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
65                  70                  75                  80
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
                85                  90                  95
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
            100                 105                 110
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
        115                 120                 125
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
    130                 135                 140
Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln
145                 150                 155                 160
Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met
                165                 170                 175
Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His
            180                 185                 190
Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly
        195                 200                 205
Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr
    210                 215                 220
Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val
225                 230                 235                 240
Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp
                245                 250                 255
Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala
            260                 265                 270
Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp
        275                 280                 285
Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly
    290                 295                 300
Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro
305                 310                 315                 320
Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly
                325                 330                 335
Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp
            340                 345                 350
Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu
        355                 360                 365
Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln
    370                 375                 380
Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val
385                 390                 395                 400
Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro
                405                 410                 415
Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val
            420                 425                 430
Trp Lys Ala Glu Leu
        435

<210> 1603
<211> 405
<212> PRT
<213> Homo sapiens

<400> 1603
Ala Arg Gly Ile Ile Ile Ala Leu Leu Ser Leu Ala Ser Ile Ile Ile
 1               5                  10                  15
Val Val Val Leu Ile Lys Val Ile Leu Asp Lys Tyr Tyr Phe Leu Cys
            20                  25                  30
Gly Gln Pro Leu His Phe Ile Pro Arg Lys Gln Leu Cys Asp Gly Glu
        35                  40                  45
Leu Asp Cys Pro Leu Gly Glu Asp Glu Glu His Cys Val Lys Ser Phe
    50                  55                  60
Pro Glu Gly Pro Ala Val Ala Val Arg Leu Ser Lys Asp Arg Ser Thr
65                  70                  75                  80
Leu Gln Val Leu Asp Ser Ala Thr Gly Asn Trp Phe Ser Ala Cys Phe
                85                  90                  95
Asp Asn Phe Thr Glu Ala Leu Ala Glu Thr Ala Cys Arg Gln Met Gly
            100                 105                 110
Tyr Ser Ser Lys Pro Thr Phe Arg Ala Val Glu Ile Gly Pro Asp Gln
        115                 120                 125
Asp Leu Asp Val Val Glu Ile Thr Glu Asn Ser Gln Glu Leu Arg Met
    130                 135                 140
Arg Asn Ser Ser Gly Pro Cys Leu Ser Gly Ser Leu Val Ser Leu His
145                 150                 155                 160
Cys Leu Ala Cys Gly Lys Ser Leu Lys Thr Pro Arg Val Val Gly Gly
                165                 170                 175
Glu Glu Ala Ser Val Asp Ser Trp Pro Trp Gln Val Ser Ile Gln Tyr
            180                 185                 190
Asp Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro His Trp Val
        195                 200                 205
Leu Thr Ala Ala His Cys Phe Arg Lys His Thr Asp Val Phe Asn Trp
    210                 215                 220
Lys Val Arg Ala Gly Ser Asp Lys Leu Gly Ser Phe Pro Ser Leu Ala
225                 230                 235                 240
Val Ala Lys Ile Ile Ile Ile Glu Phe Asn Pro Met Tyr Pro Lys Asp
                245                 250                 255
Asn Asp Ile Ala Leu Met Lys Leu Gln Phe Pro Leu Thr Phe Ser Gly
            260                 265                 270
Thr Val Arg Pro Ile Cys Leu Pro Phe Phe Asp Glu Glu Leu Thr Pro
        275                 280                 285
Ala Thr Pro Leu Trp Ile Ile Gly Trp Gly Phe Thr Lys Gln Asn Gly
    290                 295                 300
Gly Lys Met Ser Asp Ile Leu Leu Gln Ala Ser Val Gln Val Ile Asp
305                 310                 315                 320
Ser Thr Arg Cys Asn Ala Asp Asp Ala Tyr Gln Gly Glu Val Thr Glu
                325                 330                 335
Lys Met Met Cys Ala Gly Ile Pro Glu Gly Gly Val Asp Thr Cys Gln
            340                 345                 350
Gly Asp Ser Gly Gly Pro Leu Met Tyr Gln Ser Asp Gln Trp His Val
        355                 360                 365
Val Gly Ile Val Ser Trp Gly Tyr Gly Cys Gly Gly Pro Ser Thr Pro
    370                 375                 380
Gly Val Tyr Thr Lys Val Ser Ala Tyr Leu Asn Trp Ile Tyr Asn Val
385                 390                 395                 400
Trp Lys Ala Glu Leu
                405

<210> 1604
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1604
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
 1               5                  10                  15
Ser Arg


<210> 1605
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1605
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1606
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1606
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1607
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1607
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1608
<211> 449
<212> PRT
<213> Homo sapiens

<400> 1608
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Thr Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Val
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Ala Asp Ser Ala Asp Gly Glu Asp Glu Gly Glu Glu
        435                 440                 445
Tyr


<210> 1609
<211> 449
<212> PRT
<213> Homo sapiens

<400> 1609
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Thr Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Val
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Ala Asp Ser Ala Asp Gly Glu Asp Glu Gly Glu Glu
        435                 440                 445
Tyr


<210> 1610
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1610
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1611
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1611
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1612
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1612
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1613
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1613
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1614
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1614
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1615
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1615
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1616
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1616
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1617
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1617
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1618
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1618
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1619
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1619
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1620
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1620
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1621
<211> 449
<212> PRT
<213> Homo sapiens

<400> 1621
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Thr Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Val
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Ala Asp Ser Ala Asp Gly Glu Asp Glu Gly Glu Glu
        435                 440                 445
Tyr


<210> 1622
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1622
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1623
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1623
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1624
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1624
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Arg Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Asp Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Gly His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1625
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1625
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1626
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1626
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Arg Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Gly His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val His Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1627
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1627
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1628
<211> 206
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(206)
<223> Xaa = Any Amino Acid

<400> 1628
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Xaa Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Xaa His Gly Arg Gln
        195                 200                 205

<210> 1629
<211> 206
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(206)
<223> Xaa = Any Amino Acid

<400> 1629
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Xaa Xaa Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Xaa His Gly Arg Gln
        195                 200                 205

<210> 1630
<211> 161
<212> PRT
<213> Homo sapiens

<400> 1630
Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser Phe Asn
 1               5                  10                  15
Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg Ala Val
            20                  25                  30
Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr Gly Thr
        35                  40                  45
Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys Glu Asp
    50                  55                  60
Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys Glu Ile
65                  70                  75                  80
Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln Cys Thr
                85                  90                  95
Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly Thr Gly
            100                 105                 110
Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp Tyr Gly
        115                 120                 125
Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln Val Ser
    130                 135                 140
Thr Gly Glu Glu Thr Arg Val Cys Leu Glu Cys Arg Leu Gly Gly Gly
145                 150                 155                 160
Arg


<210> 1631
<211> 127
<212> PRT
<213> Homo sapiens

<400> 1631
Ala Val Ile Asp Glu Val Arg Thr Gly Thr Tyr Arg Gln Leu Phe His
 1               5                  10                  15
Pro Glu Gln Leu Ile Thr Gly Lys Glu Asp Ala Ala Asn Asn Tyr Ala
            20                  25                  30
Arg Gly His Tyr Thr Ile Gly Lys Glu Asn Ile Asp Leu Val Leu Asp
        35                  40                  45
Arg Ile Arg Lys Leu Ala Asp Gln Cys Thr Gly Leu Gln Gly Phe Leu
    50                  55                  60
Val Phe His Ser Phe Gly Gly Gly Thr Gly Ser Gly Phe Thr Ser Leu
65                  70                  75                  80
Leu Met Glu Arg Leu Ser Val Asp Tyr Gly Lys Lys Ser Lys Leu Glu
                85                  90                  95
Phe Ser Ile Tyr Pro Ala Pro Gln Val Phe Thr Ala Val Val Glu Pro
            100                 105                 110
Tyr Asn Phe Ile Leu Thr Thr His Thr Thr Leu Glu His Ser Asp
        115                 120                 125

<210> 1632
<211> 128
<212> PRT
<213> Homo sapiens

<400> 1632
Ala Val Ile Asp Glu Val Arg Thr Gly Thr Tyr Arg Gln Leu Phe His
 1               5                  10                  15
Pro Glu Gln Leu Ile Thr Gly Lys Glu Asp Ala Ala Asn Asn Tyr Ala
            20                  25                  30
Arg Gly His Tyr Thr Ile Gly Lys Glu Ile Ile Asp Leu Val Leu Asp
        35                  40                  45
Arg Ile Pro Lys Leu Ala Asp Gln Cys Thr Gly Leu Gln Gly Phe Leu
    50                  55                  60
Val Phe His Ser Phe Gly Gly Gly Thr Gly Ser Gly Phe Thr Ser Leu
65                  70                  75                  80
Leu Met Glu Arg Leu Ser Val Asp Tyr Gly Lys Lys Ser Lys Leu Glu
                85                  90                  95
Phe Tyr Ile Tyr Pro Glu Pro His Val Cys Thr Ala Val Val Glu Pro
            100                 105                 110
Tyr Asn Phe Ile Leu Thr Thr His Thr Asn Leu Glu His Ser Asp Cys
        115                 120                 125

<210> 1633
<211> 116
<212> PRT
<213> Homo sapiens

<400> 1633
Ala Ala Thr Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly
 1               5                  10                  15
Val His Ile Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly
            20                  25                  30
Ile Gln Pro Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly
        35                  40                  45
Asp Asp Ser Phe Asn Thr Phe Phe Asn Glu Thr Gly Ala Gly Lys His
    50                  55                  60
Val Pro Arg Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu
65                  70                  75                  80
Val Arg Thr Gly Thr Tyr Arg Gln Leu Phe His Pro Asp Gln Leu Ile
                85                  90                  95
Thr Gly Lys Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr
            100                 105                 110
Ile Gly Lys Glu
        115

<210> 1634
<211> 125
<212> PRT
<213> Homo sapiens

<400> 1634
Glu Ala Thr Thr Ser Thr Leu Gly Leu Arg His Gln Leu Gly Ser Arg
 1               5                  10                  15
Glu Ser Thr Ala Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala
            20                  25                  30
Gly Val His Ile Gly Asn Ala Cys Trp Glu Leu Tyr Trp Leu Glu His
        35                  40                  45
Gly Leu His Pro Asp Gly Gln Met Pro Gly Asp Gln Thr Ile Gly Gly
    50                  55                  60
Gly Asp Asp Ser Phe Asp Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys
65                  70                  75                  80
His Val Pro Arg Ala Val Leu Val Asp Leu Glu Pro Thr Val Ile Asp
                85                  90                  95
Glu Val Arg Thr Gly Thr Tyr Arg Arg Leu Phe His Pro Glu Gln Leu
            100                 105                 110
Ile Thr Gly Pro Glu Asp Ala Ala Asn Asn Tyr Ala Arg
        115                 120                 125

<210> 1635
<211> 488
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(488)
<223> Xaa = Any Amino Acid

<400> 1635
Glu Ala Thr Thr Ser Pro Leu Arg Leu Arg His Gln Leu Gly Ser Arg
 1               5                  10                  15
Glu Ala Ala Thr Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala
            20                  25                  30
Gly Val Gln Ile Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His
        35                  40                  45
Gly Ile Gln Pro Asp Gly Gln Met Pro Lys Xaa Pro Lys Pro Leu Gly
    50                  55                  60
Glu Gly Asp Asp Ser Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly
65                  70                  75                  80
Lys His Val Pro Arg Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile
                85                  90                  95
Asp Glu Val Arg Thr Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln
            100                 105                 110
Leu Ile Thr Gly Lys Glu Asp Ala Ala Asn Asn Tyr Cys Thr Gly Leu
        115                 120                 125
Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly Thr Gly Ser Gly
    130                 135                 140
Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp Tyr Trp Gln Glu
145                 150                 155                 160
Ser Pro Ser Leu Glu Phe Ser Ile Tyr Pro Ala Ala Pro Arg Phe Pro
                165                 170                 175
Gln Pro Val Val Glu Pro Tyr Asn Ser Ile Leu Pro Thr Gln His Pro
            180                 185                 190
Pro Trp Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala Ile
        195                 200                 205
Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr Thr
    210                 215                 220
Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala Ser
225                 230                 235                 240
Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln Thr
                245                 250                 255
Asn Leu Gly Pro Tyr Pro Pro Ile His Phe Pro Leu Ala Thr Tyr Ala
            260                 265                 270
Pro Cys His Leu Cys Xaa Arg Lys Pro Thr His Glu Gln Leu Phe Cys
        275                 280                 285
Ser Gln Arg Ser Pro Lys Cys Phe Ala Phe Glu Pro Thr Asn Pro Asp
    290                 295                 300
Gly Xaa Asn Gly Asp Pro Arg His Gly Xaa Ile His Trp Leu Ala Cys
305                 310                 315                 320
Leu Leu Leu Pro Arg Gly Asp Val Val Pro Lys Arg Cys Gln Met Leu
                325                 330                 335
Pro Ile Ala His Pro Ser Lys Pro Lys Arg Ser Ile Gln Phe Val Asp
            340                 345                 350
Trp Cys Pro Thr Gly Phe Lys Val Gly Ile Asn Tyr Gln Pro Pro Thr
        355                 360                 365
Val Val Pro Gly Gly Asp Leu Ala Lys Val Thr Arg Glu Ala Val Cys
    370                 375                 380
Met Leu Ser Lys His His Ser Pro Phe Ala Glu Ala Trp Ala Arg Pro
385                 390                 395                 400
Gly Pro Thr Ser Phe Asp Leu Met Leu Cys Gln Ala Cys Pro Phe Val
                405                 410                 415
His Trp Tyr Leu Gly Glu Gly Met Glu Glu Gly Glu Phe Ser Lys Ala
            420                 425                 430
Arg Lys Asp Met Ala Ala Leu Arg Lys Asp Tyr Glu Glu Val Gly Val
        435                 440                 445
Asp Ser Val Lys Gly Glu Gly Glu Glu Glu Gly Lys Gly Ile Leu Ile
    450                 455                 460
Ile His Ser Leu Phe Gly Pro Cys Ser Met Ser Cys Ser Gln Asn Phe
465                 470                 475                 480
Ser Phe Ser Leu Thr Asp Arg Arg
                485

<210> 1636
<211> 449
<212> PRT
<213> Homo sapiens

<400> 1636
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Thr Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Val
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Ala Asp Ser Ala Asp Gly Glu Asp Glu Gly Glu Glu
        435                 440                 445
Tyr


<210> 1637
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1637
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Arg Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Asp Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Gly His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1638
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1638
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Arg Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Gly His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val His Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1639
<211> 451
<212> PRT
<213> Homo sapiens

<400> 1639
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Arg Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Gly His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Val His Ser Val Glu Gly Glu Gly Glu Glu Glu Gly
        435                 440                 445
Glu Glu Tyr
    450

<210> 1640
<211> 449
<212> PRT
<213> Homo sapiens

<400> 1640
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile
 1               5                  10                  15
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro
            20                  25                  30
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser
        35                  40                  45
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg
    50                  55                  60
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr
65                  70                  75                  80
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys
                85                  90                  95
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys
            100                 105                 110
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln
        115                 120                 125
Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly
    130                 135                 140
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp
145                 150                 155                 160
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln
                165                 170                 175
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His
            180                 185                 190
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala
        195                 200                 205
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr
    210                 215                 220
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala
225                 230                 235                 240
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln
                245                 250                 255
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr
            260                 265                 270
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Thr Val
        275                 280                 285
Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys
    290                 295                 300
Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg
305                 310                 315                 320
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys
                325                 330                 335
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys
            340                 345                 350
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu
        355                 360                 365
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Val
    370                 375                 380
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala
385                 390                 395                 400
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly
                405                 410                 415
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr
            420                 425                 430
Glu Glu Val Gly Ala Asp Ser Ala Asp Gly Glu Asp Glu Gly Glu Glu
        435                 440                 445
Tyr


<210> 1641
<211> 1051
<212> PRT
<213> Homo sapiens

<400> 1641
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu
 1               5                  10                  15
Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala
            20                  25                  30
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro
        35                  40                  45
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg
    50                  55                  60
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val
65                  70                  75                  80
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu
                85                  90                  95
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn
            100                 105                 110
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val
        115                 120                 125
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr
    130                 135                 140
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly
145                 150                 155                 160
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp
                165                 170                 175
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu
            180                 185                 190
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn
        195                 200                 205
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser
    210                 215                 220
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys
225                 230                 235                 240
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val
                245                 250                 255
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala
            260                 265                 270
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala
        275                 280                 285
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly
    290                 295                 300
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly
305                 310                 315                 320
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu
                325                 330                 335
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser
            340                 345                 350
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala
        355                 360                 365
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe
    370                 375                 380
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr
385                 390                 395                 400
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val
                405                 410                 415
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr
            420                 425                 430
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu
        435                 440                 445
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro
    450                 455                 460
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu
465                 470                 475                 480
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys
                485                 490                 495
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile
            500                 505                 510
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg
        515                 520                 525
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser
    530                 535                 540
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn
545                 550                 555                 560
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu
                565                 570                 575
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp
            580                 585                 590
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu
        595                 600                 605
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn
    610                 615                 620
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser
625                 630                 635                 640
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn
                645                 650                 655
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu
            660                 665                 670
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val
        675                 680                 685
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu
    690                 695                 700
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe
705                 710                 715                 720
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu
                725                 730                 735
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu
            740                 745                 750
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn
        755                 760                 765
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly
    770                 775                 780
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln
785                 790                 795                 800
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu
                805                 810                 815
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr
            820                 825                 830
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro
        835                 840                 845
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly
    850                 855                 860
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly
865                 870                 875                 880
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala
                885                 890                 895
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val
            900                 905                 910
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr
        915                 920                 925
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
    930                 935                 940
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr
945                 950                 955                 960
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val
                965                 970                 975
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu
            980                 985                 990
Trp Leu Val Leu Val Ala Val Gly Ala Gly Leu Leu Leu Leu Gly Leu
        995                 1000                1005
Ile Ile Leu Leu Leu Trp Lys Cys Gly Phe Phe Lys Arg Ala Arg Thr
    1010                1015                1020
Arg Ala Leu Tyr Glu Ala Lys Arg Gln Lys Ala Glu Met Lys Ser Gln
1025                1030                1035                1040
Pro Ser Glu Thr Glu Arg Leu Thr Asp Asp Tyr
                1045                1050

<210> 1642
<211> 1019
<212> PRT
<213> Homo sapiens

<400> 1642
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro
 1               5                  10                  15
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg
            20                  25                  30
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val
        35                  40                  45
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu
    50                  55                  60
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn
65                  70                  75                  80
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val
                85                  90                  95
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr
            100                 105                 110
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly
        115                 120                 125
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp
    130                 135                 140
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu
145                 150                 155                 160
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn
                165                 170                 175
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser
            180                 185                 190
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys
        195                 200                 205
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val
    210                 215                 220
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala
225                 230                 235                 240
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala
                245                 250                 255
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly
            260                 265                 270
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly
        275                 280                 285
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu
    290                 295                 300
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser
305                 310                 315                 320
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala
                325                 330                 335
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe
            340                 345                 350
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr
        355                 360                 365
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val
    370                 375                 380
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr
385                 390                 395                 400
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu
                405                 410                 415
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro
            420                 425                 430
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu
        435                 440                 445
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys
    450                 455                 460
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile
465                 470                 475                 480
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg
                485                 490                 495
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser
            500                 505                 510
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn
        515                 520                 525
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu
    530                 535                 540
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp
545                 550                 555                 560
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu
                565                 570                 575
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn
            580                 585                 590
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser
        595                 600                 605
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn
    610                 615                 620
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu
625                 630                 635                 640
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val
                645                 650                 655
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu
            660                 665                 670
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe
        675                 680                 685
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu
    690                 695                 700
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu
705                 710                 715                 720
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn
                725                 730                 735
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly
            740                 745                 750
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln
        755                 760                 765
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu
    770                 775                 780
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr
785                 790                 795                 800
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro
                805                 810                 815
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly
            820                 825                 830
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly
        835                 840                 845
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala
    850                 855                 860
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val
865                 870                 875                 880
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr
                885                 890                 895
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
            900                 905                 910
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr
        915                 920                 925
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val
    930                 935                 940
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu
945                 950                 955                 960
Trp Leu Val Leu Val Ala Val Gly Ala Gly Leu Leu Leu Leu Gly Leu
                965                 970                 975
Ile Ile Leu Leu Leu Trp Lys Cys Gly Phe Phe Lys Arg Ala Arg Thr
            980                 985                 990
Arg Ala Leu Tyr Glu Ala Lys Arg Gln Lys Ala Glu Met Lys Ser Gln
        995                 1000                1005
Pro Ser Glu Thr Glu Arg Leu Thr Asp Asp Tyr
    1010                1015

<210> 1643
<211> 1019
<212> PRT
<213> Homo sapiens

<400> 1643
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro
 1               5                  10                  15
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg
            20                  25                  30
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val
        35                  40                  45
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu
    50                  55                  60
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn
65                  70                  75                  80
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val
                85                  90                  95
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr
            100                 105                 110
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly
        115                 120                 125
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp
    130                 135                 140
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu
145                 150                 155                 160
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn
                165                 170                 175
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser
            180                 185                 190
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys
        195                 200                 205
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val
    210                 215                 220
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala
225                 230                 235                 240
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala
                245                 250                 255
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly
            260                 265                 270
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly
        275                 280                 285
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu
    290                 295                 300
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser
305                 310                 315                 320
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala
                325                 330                 335
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe
            340                 345                 350
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr
        355                 360                 365
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val
    370                 375                 380
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr
385                 390                 395                 400
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu
                405                 410                 415
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro
            420                 425                 430
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu
        435                 440                 445
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys
    450                 455                 460
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile
465                 470                 475                 480
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg
                485                 490                 495
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser
            500                 505                 510
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn
        515                 520                 525
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu
    530                 535                 540
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp
545                 550                 555                 560
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu
                565                 570                 575
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn
            580                 585                 590
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser
        595                 600                 605
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn
    610                 615                 620
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu
625                 630                 635                 640
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val
                645                 650                 655
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu
            660                 665                 670
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe
        675                 680                 685
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu
    690                 695                 700
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu
705                 710                 715                 720
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn
                725                 730                 735
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly
            740                 745                 750
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln
        755                 760                 765
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu
    770                 775                 780
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr
785                 790                 795                 800
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro
                805                 810                 815
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly
            820                 825                 830
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly
        835                 840                 845
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala
    850                 855                 860
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val
865                 870                 875                 880
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr
                885                 890                 895
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
            900                 905                 910
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr
        915                 920                 925
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val
    930                 935                 940
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu
945                 950                 955                 960
Trp Leu Val Leu Val Ala Val Gly Ala Gly Leu Leu Leu Leu Gly Leu
                965                 970                 975
Ile Ile Leu Leu Leu Trp Lys Cys Gly Phe Phe Lys Arg Ala Arg Thr
            980                 985                 990
Arg Ala Leu Tyr Glu Ala Lys Arg Gln Lys Ala Asp Met Lys Ser Gln
        995                 1000                1005
Pro Ser Glu Thr Glu Arg Leu Thr Asp Asp Tyr
    1010                1015

<210> 1644
<211> 1051
<212> PRT
<213> Homo sapiens

<400> 1644
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu
 1               5                  10                  15
Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala
            20                  25                  30
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro
        35                  40                  45
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg
    50                  55                  60
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val
65                  70                  75                  80
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu
                85                  90                  95
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn
            100                 105                 110
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val
        115                 120                 125
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr
    130                 135                 140
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly
145                 150                 155                 160
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp
                165                 170                 175
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu
            180                 185                 190
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn
        195                 200                 205
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser
    210                 215                 220
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys
225                 230                 235                 240
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val
                245                 250                 255
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala
            260                 265                 270
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala
        275                 280                 285
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly
    290                 295                 300
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly
305                 310                 315                 320
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu
                325                 330                 335
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser
            340                 345                 350
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala
        355                 360                 365
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe
    370                 375                 380
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr
385                 390                 395                 400
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val
                405                 410                 415
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr
            420                 425                 430
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu
        435                 440                 445
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro
    450                 455                 460
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu
465                 470                 475                 480
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys
                485                 490                 495
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile
            500                 505                 510
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg
        515                 520                 525
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser
    530                 535                 540
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn
545                 550                 555                 560
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu
                565                 570                 575
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp
            580                 585                 590
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu
        595                 600                 605
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn
    610                 615                 620
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser
625                 630                 635                 640
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn
                645                 650                 655
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu
            660                 665                 670
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val
        675                 680                 685
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu
    690                 695                 700
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe
705                 710                 715                 720
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu
                725                 730                 735
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu
            740                 745                 750
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn
        755                 760                 765
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly
    770                 775                 780
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln
785                 790                 795                 800
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu
                805                 810                 815
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr
            820                 825                 830
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro
        835                 840                 845
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly
    850                 855                 860
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly
865                 870                 875                 880
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala
                885                 890                 895
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val
            900                 905                 910
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr
        915                 920                 925
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
    930                 935                 940
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr
945                 950                 955                 960
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val
                965                 970                 975
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu
            980                 985                 990
Trp Leu Val Leu Val Ala Val Gly Ala Gly Leu Leu Leu Leu Gly Leu
        995                 1000                1005
Ile Ile Leu Leu Leu Trp Lys Cys Gly Phe Phe Lys Arg Ala Arg Thr
    1010                1015                1020
Arg Ala Leu Tyr Glu Ala Lys Arg Gln Lys Ala Glu Met Lys Ser Gln
1025                1030                1035                1040
Pro Ser Glu Thr Glu Arg Leu Thr Asp Asp Tyr
                1045                1050

<210> 1645
<211> 1051
<212> PRT
<213> Homo sapiens

<400> 1645
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu
 1               5                  10                  15
Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala
            20                  25                  30
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro
        35                  40                  45
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg
    50                  55                  60
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val
65                  70                  75                  80
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu
                85                  90                  95
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn
            100                 105                 110
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val
        115                 120                 125
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr
    130                 135                 140
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly
145                 150                 155                 160
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp
                165                 170                 175
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu
            180                 185                 190
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn
        195                 200                 205
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser
    210                 215                 220
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys
225                 230                 235                 240
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val
                245                 250                 255
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala
            260                 265                 270
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala
        275                 280                 285
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly
    290                 295                 300
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly
305                 310                 315                 320
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu
                325                 330                 335
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser
            340                 345                 350
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala
        355                 360                 365
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe
    370                 375                 380
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr
385                 390                 395                 400
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val
                405                 410                 415
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr
            420                 425                 430
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu
        435                 440                 445
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro
    450                 455                 460
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu
465                 470                 475                 480
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys
                485                 490                 495
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile
            500                 505                 510
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg
        515                 520                 525
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser
    530                 535                 540
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn
545                 550                 555                 560
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu
                565                 570                 575
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp
            580                 585                 590
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu
        595                 600                 605
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn
    610                 615                 620
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser
625                 630                 635                 640
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn
                645                 650                 655
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu
            660                 665                 670
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val
        675                 680                 685
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu
    690                 695                 700
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe
705                 710                 715                 720
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu
                725                 730                 735
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu
            740                 745                 750
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn
        755                 760                 765
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly
    770                 775                 780
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln
785                 790                 795                 800
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu
                805                 810                 815
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr
            820                 825                 830
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro
        835                 840                 845
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly
    850                 855                 860
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly
865                 870                 875                 880
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala
                885                 890                 895
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val
            900                 905                 910
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr
        915                 920                 925
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
    930                 935                 940
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr
945                 950                 955                 960
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val
                965                 970                 975
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu
            980                 985                 990
Trp Leu Val Leu Val Ala Val Gly Ala Gly Leu Leu Leu Leu Gly Leu
        995                 1000                1005
Ile Ile Leu Leu Leu Trp Lys Cys Gly Phe Phe Lys Arg Ala Arg Thr
    1010                1015                1020
Arg Ala Leu Tyr Glu Ala Lys Arg Gln Lys Ala Glu Met Lys Ser Gln
1025                1030                1035                1040
Pro Ser Glu Thr Glu Arg Leu Thr Asp Asp Tyr
                1045                1050

<210> 1646
<211> 1066
<212> PRT
<213> Homo sapiens

<400> 1646
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu
 1               5                  10                  15
Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala
            20                  25                  30
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro
        35                  40                  45
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg
    50                  55                  60
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val
65                  70                  75                  80
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu
                85                  90                  95
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn
            100                 105                 110
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val
        115                 120                 125
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr
    130                 135                 140
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly
145                 150                 155                 160
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp
                165                 170                 175
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu
            180                 185                 190
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn
        195                 200                 205
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser
    210                 215                 220
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys
225                 230                 235                 240
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val
                245                 250                 255
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala
            260                 265                 270
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala
        275                 280                 285
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly
    290                 295                 300
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly
305                 310                 315                 320
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu
                325                 330                 335
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser
            340                 345                 350
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala
        355                 360                 365
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe
    370                 375                 380
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr
385                 390                 395                 400
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val
                405                 410                 415
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr
            420                 425                 430
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu
        435                 440                 445
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro
    450                 455                 460
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu
465                 470                 475                 480
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys
                485                 490                 495
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile
            500                 505                 510
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg
        515                 520                 525
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser
    530                 535                 540
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn
545                 550                 555                 560
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu
                565                 570                 575
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp
            580                 585                 590
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu
        595                 600                 605
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn
    610                 615                 620
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser
625                 630                 635                 640
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn
                645                 650                 655
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu
            660                 665                 670
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val
        675                 680                 685
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu
    690                 695                 700
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe
705                 710                 715                 720
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu
                725                 730                 735
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu
            740                 745                 750
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn
        755                 760                 765
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly
    770                 775                 780
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln
785                 790                 795                 800
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu
                805                 810                 815
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr
            820                 825                 830
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro
        835                 840                 845
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly
    850                 855                 860
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly
865                 870                 875                 880
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala
                885                 890                 895
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val
            900                 905                 910
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr
        915                 920                 925
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
    930                 935                 940
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr
945                 950                 955                 960
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val
                965                 970                 975
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu
            980                 985                 990
Trp Leu Val Leu Val Ala Val Gly Ala Gly Leu Leu Leu Leu Gly Leu
        995                 1000                1005
Ile Ile Leu Leu Leu Trp Lys Cys Asp Phe Phe Lys Arg Thr Arg Tyr
    1010                1015                1020
Tyr Gln Ile Met Pro Lys Tyr His Ala Val Arg Ile Arg Glu Glu Glu
1025                1030                1035                1040
Arg Tyr Pro Pro Pro Gly Ser Thr Leu Pro Thr Lys Lys His Trp Val
                1045                1050                1055
Thr Ser Trp Gln Thr Arg Asp Gln Tyr Tyr
            1060                1065

<210> 1647
<211> 1066
<212> PRT
<213> Homo sapiens

<400> 1647
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu
 1               5                  10                  15
Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala
            20                  25                  30
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro
        35                  40                  45
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg
    50                  55                  60
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val
65                  70                  75                  80
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu
                85                  90                  95
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn
            100                 105                 110
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val
        115                 120                 125
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr
    130                 135                 140
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly
145                 150                 155                 160
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp
                165                 170                 175
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu
            180                 185                 190
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn
        195                 200                 205
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser
    210                 215                 220
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys
225                 230                 235                 240
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val
                245                 250                 255
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala
            260                 265                 270
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala
        275                 280                 285
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly
    290                 295                 300
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly
305                 310                 315                 320
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu
                325                 330                 335
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser
            340                 345                 350
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala
        355                 360                 365
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe
    370                 375                 380
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr
385                 390                 395                 400
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val
                405                 410                 415
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr
            420                 425                 430
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu
        435                 440                 445
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro
    450                 455                 460
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu
465                 470                 475                 480
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys
                485                 490                 495
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile
            500                 505                 510
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg
        515                 520                 525
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser
    530                 535                 540
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn
545                 550                 555                 560
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu
                565                 570                 575
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp
            580                 585                 590
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu
        595                 600                 605
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn
    610                 615                 620
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser
625                 630                 635                 640
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn
                645                 650                 655
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu
            660                 665                 670
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val
        675                 680                 685
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu
    690                 695                 700
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe
705                 710                 715                 720
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu
                725                 730                 735
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu
            740                 745                 750
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn
        755                 760                 765
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly
    770                 775                 780
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln
785                 790                 795                 800
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu
                805                 810                 815
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr
            820                 825                 830
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro
        835                 840                 845
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly
    850                 855                 860
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly
865                 870                 875                 880
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala
                885                 890                 895
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val
            900                 905                 910
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr
        915                 920                 925
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
    930                 935                 940
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr
945                 950                 955                 960
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val
                965                 970                 975
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu
            980                 985                 990
Trp Leu Val Leu Val Ala Val Gly Ala Gly Leu Leu Leu Leu Gly Leu
        995                 1000                1005
Ile Ile Leu Leu Leu Trp Lys Cys Gly Phe Phe Lys Arg Thr Arg Tyr
    1010                1015                1020
Tyr Gln Ile Met Pro Lys Tyr His Ala Val Arg Ile Arg Glu Glu Glu
1025                1030                1035                1040
Arg Tyr Pro Pro Pro Gly Ser Thr Leu Pro Thr Lys Lys His Trp Val
                1045                1050                1055
Thr Ser Trp Gln Thr Arg Asp Gln Tyr Tyr
            1060                1065

<210> 1648
<211> 572
<212> PRT
<213> Homo sapiens

<400> 1648
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Val Ser Gly Ser Arg Arg
                565                 570

<210> 1649
<211> 572
<212> PRT
<213> Homo sapiens

<400> 1649
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Val Ser Gly Ser Arg Arg
                565                 570

<210> 1650
<211> 572
<212> PRT
<213> Homo sapiens

<400> 1650
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Val Ser Gly Ser Arg Arg
                565                 570

<210> 1651
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1651
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro
                565                 570                 575
Ala Glu Tyr Asn Leu Arg Leu Ala His Arg Ala Val Arg Asp Leu Arg
            580                 585                 590
Ala Ala Cys Arg Gln Gly Ile Cys Gln Arg Leu Arg Ser Pro Gly Gly
        595                 600                 605
Arg Thr His Leu Leu Trp Leu Phe Cys Leu Gln Cys His Gly His Ser
    610                 615                 620
Gln Leu Pro Gln Cys Gly Gly Gln Trp Gly Trp Gln Leu Arg Gly Gln
625                 630                 635                 640
Ser Gly His Pro Leu Leu Pro Pro Gly Gln Leu Gln Pro Pro Asn Pro
                645                 650                 655
Glu Pro Pro Glu Leu Gln His His Val Ile Trp Asp Leu Pro Gly Arg
            660                 665                 670
Gly Gly Gly Gly Gly Phe Leu Arg Pro Pro His Leu Met Pro Thr Pro
        675                 680                 685
Cys Pro Ala Arg His Gly Arg Gly Leu Glu Ala Lys Glu Lys
    690                 695                 700

<210> 1652
<211> 572
<212> PRT
<213> Homo sapiens

<400> 1652
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Val Ser Gly Ser Arg Arg
                565                 570

<210> 1653
<211> 120
<212> PRT
<213> Homo sapiens

<400> 1653
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn
        115                 120

<210> 1654
<211> 572
<212> PRT
<213> Homo sapiens

<400> 1654
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Val Ser Gly Ser Arg Arg
                565                 570

<210> 1655
<211> 572
<212> PRT
<213> Homo sapiens

<400> 1655
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Val Ser Gly Ser Arg Arg
                565                 570

<210> 1656
<211> 120
<212> PRT
<213> Homo sapiens

<400> 1656
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn
        115                 120

<210> 1657
<211> 572
<212> PRT
<213> Homo sapiens

<400> 1657
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Val Ser Gly Ser Arg Arg
                565                 570

<210> 1658
<211> 664
<212> PRT
<213> Homo sapiens

<400> 1658
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro
                565                 570                 575
Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly
            580                 585                 590
Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly
        595                 600                 605
Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg
    610                 615                 620
Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn
625                 630                 635                 640
Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln
                645                 650                 655
Ser Pro Gln Asn Cys Ser Ile Met
            660

<210> 1659
<211> 572
<212> PRT
<213> Homo sapiens

<400> 1659
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560
Leu Leu His His His His Val Ser Gly Ser Arg Arg
                565                 570

<210> 1660
<211> 93
<212> PRT
<213> Homo sapiens

<400> 1660
Met Phe Pro Thr Glu Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15
Gly Pro Glu Ala Ala Val Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala
                85                  90

<210> 1661
<211> 93
<212> PRT
<213> Homo sapiens

<400> 1661
Met Phe Pro Thr Glu Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15
Gly Pro Glu Ala Ala Val Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala
                85                  90

<210> 1662
<211> 125
<212> PRT
<213> Homo sapiens

<400> 1662
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Phe Ser Thr Leu Ala Gln Leu Lys
        35                  40                  45
Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln Thr Leu Leu
    50                  55                  60
Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Leu Asp Lys Asp
65                  70                  75                  80
Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr Glu Gly Leu Asp
                85                  90                  95
Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr Leu Arg Thr Gly
            100                 105                 110
Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln Glu
        115                 120                 125

<210> 1663
<211> 246
<212> PRT
<213> Homo sapiens

<400> 1663
Arg Ser Leu Gly Arg Cys His Gly Phe Gly Val Gly Asp Arg Ala Val
 1               5                  10                  15
Thr Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val
            20                  25                  30
Ala Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser
        35                  40                  45
Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp
    50                  55                  60
Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met
65                  70                  75                  80
His Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys
                85                  90                  95
Gln Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg
            100                 105                 110
Met Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly
        115                 120                 125
Ile Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn
    130                 135                 140
Asn Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met
145                 150                 155                 160
Gly Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp
                165                 170                 175
Gly Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val
            180                 185                 190
Pro Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu
        195                 200                 205
Glu Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr
    210                 215                 220
Glu Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly
225                 230                 235                 240
Glu His Pro Gly Gln Glu
                245

<210> 1664
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1664
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln
        35                  40                  45
Ser Pro Arg Phe Ile Ala Arg Lys Arg Arg Phe Thr Val Lys Met His
    50                  55                  60
Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln
65                  70                  75                  80
Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met
                85                  90                  95
Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile
            100                 105                 110
Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn
        115                 120                 125
Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly
    130                 135                 140
Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly
145                 150                 155                 160
Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro
                165                 170                 175
Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu
            180                 185                 190
Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
        195                 200                 205
Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu
    210                 215                 220
His Pro Gly Gln Glu
225

<210> 1665
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1665
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln
        35                  40                  45
Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His
    50                  55                  60
Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln
65                  70                  75                  80
Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met
                85                  90                  95
Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile
            100                 105                 110
Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn
        115                 120                 125
Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly
    130                 135                 140
Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly
145                 150                 155                 160
Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro
                165                 170                 175
Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu
            180                 185                 190
Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
        195                 200                 205
Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu
    210                 215                 220
His Pro Gly Gln Glu
225

<210> 1666
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1666
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln
        35                  40                  45
Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His
    50                  55                  60
Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln
65                  70                  75                  80
Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met
                85                  90                  95
Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile
            100                 105                 110
Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn
        115                 120                 125
Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly
    130                 135                 140
Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly
145                 150                 155                 160
Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro
                165                 170                 175
Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu
            180                 185                 190
Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
        195                 200                 205
Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu
    210                 215                 220
His Pro Gly Gln Glu
225

<210> 1667
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1667
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln
        35                  40                  45
Ser Pro Arg Phe Ile Ala Arg Lys Arg Ala Phe Thr Val Lys Met His
    50                  55                  60
Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln
65                  70                  75                  80
Glu Met Asp Ala Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met
                85                  90                  95
Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile
            100                 105                 110
Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn
        115                 120                 125
Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly
    130                 135                 140
Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly
145                 150                 155                 160
Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro
                165                 170                 175
Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu
            180                 185                 190
Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
        195                 200                 205
Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu
    210                 215                 220
His Pro Gly Gln Glu
225

<210> 1668
<211> 125
<212> PRT
<213> Homo sapiens

<400> 1668
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Phe Ser Thr Leu Ala Gln Leu Lys
        35                  40                  45
Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln Thr Leu Leu
    50                  55                  60
Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Leu Asp Lys Asp
65                  70                  75                  80
Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr Glu Gly Leu Asp
                85                  90                  95
Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr Leu Arg Thr Gly
            100                 105                 110
Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln Glu
        115                 120                 125

<210> 1669
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1669
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln
        35                  40                  45
Ser Pro Arg Phe Ile Ala Arg Lys Arg Arg Phe Thr Val Lys Met His
    50                  55                  60
Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln
65                  70                  75                  80
Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met
                85                  90                  95
Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile
            100                 105                 110
Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn
        115                 120                 125
Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly
    130                 135                 140
Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly
145                 150                 155                 160
Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro
                165                 170                 175
Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu
            180                 185                 190
Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
        195                 200                 205
Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu
    210                 215                 220
His Pro Gly Gln Glu
225

<210> 1670
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1670
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln
        35                  40                  45
Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His
    50                  55                  60
Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln
65                  70                  75                  80
Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met
                85                  90                  95
Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile
            100                 105                 110
Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn
        115                 120                 125
Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly
    130                 135                 140
Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly
145                 150                 155                 160
Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro
                165                 170                 175
Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu
            180                 185                 190
Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
        195                 200                 205
Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu
    210                 215                 220
His Pro Gly Gln Glu
225

<210> 1671
<211> 125
<212> PRT
<213> Homo sapiens

<400> 1671
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Phe Ser Thr Leu Ala Gln Leu Lys
        35                  40                  45
Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln Thr Leu Leu
    50                  55                  60
Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Leu Asp Lys Asp
65                  70                  75                  80
Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr Glu Gly Leu Asp
                85                  90                  95
Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr Leu Arg Thr Gly
            100                 105                 110
Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln Glu
        115                 120                 125

<210> 1672
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1672
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30
Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln
        35                  40                  45
Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His
    50                  55                  60
Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln
65                  70                  75                  80
Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met
                85                  90                  95
Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile
            100                 105                 110
Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn
        115                 120                 125
Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly
    130                 135                 140
Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly
145                 150                 155                 160
Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro
                165                 170                 175
Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu
            180                 185                 190
Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
        195                 200                 205
Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu
    210                 215                 220
His Pro Gly Gln Glu
225

<210> 1673
<211> 246
<212> PRT
<213> Homo sapiens

<400> 1673
Arg Ser Leu Gly Arg Cys His Gly Phe Gly Val Gly Asp Arg Ala Val
 1               5                  10                  15
Thr Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val
            20                  25                  30
Ala Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser
        35                  40                  45
Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp
    50                  55                  60
Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met
65                  70                  75                  80
His Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys
                85                  90                  95
Gln Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg
            100                 105                 110
Met Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly
        115                 120                 125
Ile Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn
    130                 135                 140
Asn Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met
145                 150                 155                 160
Gly Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp
                165                 170                 175
Gly Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val
            180                 185                 190
Pro Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu
        195                 200                 205
Glu Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr
    210                 215                 220
Glu Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly
225                 230                 235                 240
Glu His Pro Gly Gln Glu
                245

<210> 1674
<211> 252
<212> PRT
<213> Homo sapiens

<400> 1674
Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn
    130                 135                 140
Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val
145                 150                 155                 160
Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu
                165                 170                 175
Ala Lys Thr Gly Arg Thr Ser Ile Gln Arg Asp Leu Lys Glu Gln Gln
            180                 185                 190
Pro Gln Ala Leu Ala Pro Gly Arg Gly Pro Ser His Ser Ser Ala Phe
        195                 200                 205
Ser Met Ser Pro Leu Ser Ser Ala Gln Ala Pro Leu Pro Asn Pro Arg
    210                 215                 220
Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys His Asp Thr Asn Ile
225                 230                 235                 240
Tyr Cys Arg Met Asp His Lys Ala Glu Val Ala Ser
                245                 250

<210> 1675
<211> 212
<212> PRT
<213> Homo sapiens

<400> 1675
Met Gly Pro Pro Ser Ala Pro Pro His Arg Glu Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn
    130                 135                 140
Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val
145                 150                 155                 160
Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu
                165                 170                 175
Ala Lys Thr Gly Arg Pro Trp Ser Leu Pro Gln Leu Cys Leu Leu Asp
            180                 185                 190
Val Pro Ser Leu His Cys Leu Gly Pro Pro Thr Gln Pro Gln Asp Ser
        195                 200                 205
Ser Phe His Leu
    210

<210> 1676
<211> 143
<212> PRT
<213> Homo sapiens

<400> 1676
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Arg Glu
    130                 135                 140

<210> 1677
<211> 177
<212> PRT
<213> Homo sapiens

<400> 1677
Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Thr Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly His Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Lys Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ile His Ser Thr Thr Cys
                165                 170                 175
Leu


<210> 1678
<211> 141
<212> PRT
<213> Homo sapiens

<400> 1678
Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile His Asn Val
            100                 105                 110
Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr
    130                 135                 140

<210> 1679
<211> 430
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(430)
<223> Xaa = Any Amino Acid

<400> 1679
Arg Thr Ala Asp Gln Thr Val Thr Ala Ala Leu Thr Lys Arg Ser Trp
 1               5                  10                  15
Asn Ser Ser Ser Ser Pro Gln Arg Arg Thr Glu Gln Thr Ala Glu Thr
            20                  25                  30
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
        35                  40                  45
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
    50                  55                  60
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
65                  70                  75                  80
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
                85                  90                  95
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
            100                 105                 110
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
        115                 120                 125
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
    130                 135                 140
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
145                 150                 155                 160
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
                165                 170                 175
Pro Lys Pro Ser Ile Xaa Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
            180                 185                 190
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
        195                 200                 205
Leu Trp Trp Val Asn Asn Gln Xaa Leu Pro Val Ser Pro Arg Leu Gln
    210                 215                 220
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
225                 230                 235                 240
Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
                245                 250                 255
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
            260                 265                 270
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
        275                 280                 285
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
    290                 295                 300
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
305                 310                 315                 320
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
                325                 330                 335
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
            340                 345                 350
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
        355                 360                 365
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
    370                 375                 380
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
385                 390                 395                 400
Leu His Leu Pro Met Thr Thr Xaa Pro Xaa Leu Tyr Ser Xaa Ala Gln
                405                 410                 415
Gly Met Met Xaa Asp Pro Met Asn Val Glu Ser Xaa Thr Asn
            420                 425                 430

<210> 1680
<211> 92
<212> PRT
<213> Homo sapiens

<400> 1680
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly
                85                  90

<210> 1681
<211> 177
<212> PRT
<213> Homo sapiens

<400> 1681
Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Thr Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly His Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Lys Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ile His Ser Thr Thr Cys
                165                 170                 175
Leu


<210> 1682
<211> 92
<212> PRT
<213> Homo sapiens

<400> 1682
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly
                85                  90

<210> 1683
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1683
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1684
<211> 102
<212> PRT
<213> Homo sapiens

<400> 1684
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Gly Tyr Val Ile Gly Thr Gly
        35                  40                  45
Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg Glu Ile Ile Tyr Pro
    50                  55                  60
Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln Asn Asp Thr Gly Phe
65                  70                  75                  80
Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val Asn Glu Glu Ala Thr
                85                  90                  95
Gly Gln Phe Arg Val Tyr
            100

<210> 1685
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1685
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asp Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1686
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1686
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Lys Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1687
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1687
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1688
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1688
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Arg Ile Val Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1689
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1689
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Ala
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1690
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1690
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Arg
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1691
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1691
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Ala Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1692
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1692
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asn Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1693
<211> 101
<212> PRT
<213> Homo sapiens

<400> 1693
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Glu Arg
            20                  25                  30
Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr Val Ile Gly Thr Gly Gly
        35                  40                  45
Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg Glu Ile Ile Tyr Pro Asn
    50                  55                  60
Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln Asn Asp Thr Gly Phe Tyr
65                  70                  75                  80
Thr Leu His Val Ile Lys Ser Asp Leu Val Asn Glu Glu Ala Thr Gly
                85                  90                  95
Gln Phe Arg Val Tyr
            100

<210> 1694
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1694
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Ala Ser
            20                  25                  30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1695
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1695
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Ala Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1696
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1696
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Phe Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1697
<211> 107
<212> PRT
<213> Homo sapiens

<400> 1697
Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu
 1               5                  10                  15
Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser
            20                  25                  30
Trp Tyr Ala Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr
        35                  40                  45
Val Ile Gly Thr Gly Gly Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg
    50                  55                  60
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln
65                  70                  75                  80
Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val
                85                  90                  95
Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr
            100                 105

<210> 1698
<211> 212
<212> PRT
<213> Homo sapiens

<400> 1698
Met Gly Pro Pro Ser Ala Pro Pro His Arg Glu Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn
    130                 135                 140
Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val
145                 150                 155                 160
Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu
                165                 170                 175
Ala Lys Thr Gly Arg Pro Trp Ser Leu Pro Gln Leu Cys Leu Leu Asp
            180                 185                 190
Val Pro Ser Leu His Cys Leu Gly Pro Pro Thr Gln Pro Gln Asp Ser
        195                 200                 205
Ser Phe His Leu
    210

<210> 1699
<211> 252
<212> PRT
<213> Homo sapiens

<400> 1699
Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn
    130                 135                 140
Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val
145                 150                 155                 160
Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu
                165                 170                 175
Ala Lys Thr Gly Arg Thr Ser Ile Gln Arg Asp Leu Lys Glu Gln Gln
            180                 185                 190
Pro Gln Ala Leu Ala Pro Gly Arg Gly Pro Ser His Ser Ser Ala Phe
        195                 200                 205
Ser Met Ser Pro Leu Ser Ser Ala Gln Ala Pro Leu Pro Asn Pro Arg
    210                 215                 220
Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys His Asp Thr Asn Ile
225                 230                 235                 240
Tyr Cys Arg Met Asp His Lys Ala Glu Val Ala Ser
                245                 250

<210> 1700
<211> 143
<212> PRT
<213> Homo sapiens

<400> 1700
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Arg Glu
    130                 135                 140

<210> 1701
<211> 141
<212> PRT
<213> Homo sapiens

<400> 1701
Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile His Asn Val
            100                 105                 110
Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr
    130                 135                 140

<210> 1702
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1702
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1703
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1703
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1704
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1704
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1705
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1705
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1706
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1706
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1707
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1707
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1708
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1708
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1709
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1709
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1710
<211> 276
<212> PRT
<213> Homo sapiens

<400> 1710
Asp Arg Arg Gly Ile Gly Ile Met Ala Ala Ala Leu Phe Val Leu Leu
 1               5                  10                  15
Gly Phe Ala Leu Leu Gly Thr His Gly Ala Ser Gly Ala Ala Gly Thr
            20                  25                  30
Val Phe Thr Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys
        35                  40                  45
Ser Leu Asn Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys
    50                  55                  60
Gly Gly Val Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu
65                  70                  75                  80
Phe Lys Val Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe
                85                  90                  95
Leu Pro Glu Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro
            100                 105                 110
Arg Val Lys Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr
        115                 120                 125
Ala Met Leu Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp
    130                 135                 140
Ala Trp Tyr Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly
145                 150                 155                 160
Ser Glu Ser Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu
                165                 170                 175
His Ile Glu Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys
            180                 185                 190
Asn Gly Thr Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg
        195                 200                 205
Val Arg Ser His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala
    210                 215                 220
Glu Val Leu Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg
225                 230                 235                 240
Lys Pro Glu Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu
                245                 250                 255
Lys Ser Ser Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln
            260                 265                 270
Arg Asn Ser Ser
        275

<210> 1711
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1711
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1712
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1712
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1713
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1713
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265

<210> 1714
<211> 228
<212> PRT
<213> Homo sapiens

<400> 1714
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
 1               5                  10                  15
Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
            20                  25                  30
Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
        35                  40                  45
Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
    50                  55                  60
Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
65                  70                  75                  80
Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
                85                  90                  95
Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
            100                 105                 110
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
        115                 120                 125
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
    130                 135                 140
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145                 150                 155                 160
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
                165                 170                 175
Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
            180                 185                 190
Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile
        195                 200                 205
Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn
    210                 215                 220
Arg Glu Met Val
225

<210> 1715
<211> 228
<212> PRT
<213> Homo sapiens

<400> 1715
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
 1               5                  10                  15
Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
            20                  25                  30
Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
        35                  40                  45
Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
    50                  55                  60
Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
65                  70                  75                  80
Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
                85                  90                  95
Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
            100                 105                 110
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
        115                 120                 125
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
    130                 135                 140
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145                 150                 155                 160
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
                165                 170                 175
Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
            180                 185                 190
Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile
        195                 200                 205
Phe Gly Met Ile Phe Ser Thr Ile Leu Cys Cys Ala Ile Arg Arg Asn
    210                 215                 220
Arg Glu Met Val
225

<210> 1716
<211> 228
<212> PRT
<213> Homo sapiens

<400> 1716
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
 1               5                  10                  15
Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
            20                  25                  30
Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
        35                  40                  45
Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
    50                  55                  60
Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
65                  70                  75                  80
Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
                85                  90                  95
Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
            100                 105                 110
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
        115                 120                 125
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
    130                 135                 140
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145                 150                 155                 160
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
                165                 170                 175
Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
            180                 185                 190
Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile
        195                 200                 205
Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn
    210                 215                 220
Arg Glu Met Val
225

<210> 1717
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1717
Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln Phe Ile Ser Asp
 1               5                  10                  15
Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr Val Lys
            20                  25                  30

<210> 1718
<211> 228
<212> PRT
<213> Homo sapiens

<400> 1718
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
 1               5                  10                  15
Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
            20                  25                  30
Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
        35                  40                  45
Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
    50                  55                  60
Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
65                  70                  75                  80
Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
                85                  90                  95
Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
            100                 105                 110
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
        115                 120                 125
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
    130                 135                 140
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145                 150                 155                 160
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
                165                 170                 175
Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
            180                 185                 190
Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile
        195                 200                 205
Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn
    210                 215                 220
Arg Glu Met Val
225

<210> 1719
<211> 228
<212> PRT
<213> Homo sapiens

<400> 1719
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
 1               5                  10                  15
Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
            20                  25                  30
Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
        35                  40                  45
Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
    50                  55                  60
Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
65                  70                  75                  80
Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
                85                  90                  95
Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
            100                 105                 110
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
        115                 120                 125
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
    130                 135                 140
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145                 150                 155                 160
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
                165                 170                 175
Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
            180                 185                 190
Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile
        195                 200                 205
Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn
    210                 215                 220
Arg Glu Met Val
225

<210> 1720
<211> 275
<212> PRT
<213> Homo sapiens

<400> 1720
Gly Val Ala Leu Phe Lys Ser Ala Ala Gly Asp Gln Pro Thr Ala Ala
 1               5                  10                  15
Cys Ile Cys Ile Gln Arg Gln Val Pro Pro Val Pro Ala Ala Arg Ala
            20                  25                  30
Pro Gln Ser Arg Thr Arg Ser Ala Gln Ala Lys Leu Ala Leu Thr Met
        35                  40                  45
Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe
    50                  55                  60
Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu
65                  70                  75                  80
Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr
                85                  90                  95
Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly
            100                 105                 110
Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala
        115                 120                 125
Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu
    130                 135                 140
Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His
145                 150                 155                 160
Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr
                165                 170                 175
Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala
            180                 185                 190
Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln
        195                 200                 205
Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr
    210                 215                 220
Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe
225                 230                 235                 240
His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe
                245                 250                 255
Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg
            260                 265                 270
Glu Met Val
        275

<210> 1721
<211> 275
<212> PRT
<213> Homo sapiens

<400> 1721
Gly Val Ala Leu Phe Lys Ser Ala Ala Gly Asp Gln Pro Thr Ala Ala
 1               5                  10                  15
Cys Ile Cys Ile Gln Arg Gln Val Pro Pro Val Pro Ala Ala Arg Ala
            20                  25                  30
Pro Gln Ser Arg Thr Arg Ser Ala Gln Ala Lys Leu Ala Leu Thr Met
        35                  40                  45
Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe
    50                  55                  60
Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu
65                  70                  75                  80
Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr
                85                  90                  95
Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly
            100                 105                 110
Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala
        115                 120                 125
Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu
    130                 135                 140
Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His
145                 150                 155                 160
Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr
                165                 170                 175
Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala
            180                 185                 190
Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln
        195                 200                 205
Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr
    210                 215                 220
Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe
225                 230                 235                 240
His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe
                245                 250                 255
Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg
            260                 265                 270
Glu Met Val
        275

<210> 1722
<211> 228
<212> PRT
<213> Homo sapiens

<400> 1722
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
 1               5                  10                  15
Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
            20                  25                  30
Leu Trp Leu Arg Val Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
        35                  40                  45
Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
    50                  55                  60
Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
65                  70                  75                  80
Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
                85                  90                  95
Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
            100                 105                 110
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
        115                 120                 125
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
    130                 135                 140
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145                 150                 155                 160
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
                165                 170                 175
Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
            180                 185                 190
Phe His Ile Ile Gly Gly Val Gly Ile Gly Ile Ala Val Val Met Ile
        195                 200                 205
Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn
    210                 215                 220
Arg Glu Met Val
225

<210> 1723
<211> 227
<212> PRT
<213> Homo sapiens

<400> 1723
Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe
 1               5                  10                  15
Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu
            20                  25                  30
Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr
        35                  40                  45
Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly
    50                  55                  60
Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala
65                  70                  75                  80
Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu
                85                  90                  95
Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His
            100                 105                 110
Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr
        115                 120                 125
Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala
    130                 135                 140
Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln
145                 150                 155                 160
Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr
                165                 170                 175
Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe
            180                 185                 190
His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe
        195                 200                 205
Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg
    210                 215                 220
Glu Met Val
225

<210> 1724
<211> 79
<212> PRT
<213> Homo sapiens

<400> 1724
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
 1               5                  10                  15
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
            20                  25                  30
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Ala
        35                  40                  45
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
    50                  55                  60
Thr Val Lys Ser Cys Pro Asp Ile Lys Glu Val Phe Asp Asn Lys
65                  70                  75

<210> 1725
<211> 228
<212> PRT
<213> Homo sapiens

<400> 1725
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
 1               5                  10                  15
Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
            20                  25                  30
Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
        35                  40                  45
Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
    50                  55                  60
Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
65                  70                  75                  80
Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
                85                  90                  95
Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
            100                 105                 110
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
        115                 120                 125
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
    130                 135                 140
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145                 150                 155                 160
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
                165                 170                 175
Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
            180                 185                 190
Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile
        195                 200                 205
Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn
    210                 215                 220
Arg Glu Met Val
225

<210> 1726
<211> 227
<212> PRT
<213> Homo sapiens

<400> 1726
Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe
 1               5                  10                  15
Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu
            20                  25                  30
Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr
        35                  40                  45
Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly
    50                  55                  60
Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala
65                  70                  75                  80
Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu
                85                  90                  95
Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His
            100                 105                 110
Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr
        115                 120                 125
Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala
    130                 135                 140
Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln
145                 150                 155                 160
Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr
                165                 170                 175
Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe
            180                 185                 190
His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe
        195                 200                 205
Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg
    210                 215                 220
Glu Met Val
225

<210> 1727
<211> 195
<212> PRT
<213> Homo sapiens

<400> 1727
Met Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu
 1               5                  10                  15
Glu Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu
            20                  25                  30
Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly
        35                  40                  45
Asp Gln Pro Ala Ala Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro
    50                  55                  60
Leu Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg
65                  70                  75                  80
Phe Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys
                85                  90                  95
Val Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro
            100                 105                 110
Tyr Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe
        115                 120                 125
Cys Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp
    130                 135                 140
Leu Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe
145                 150                 155                 160
Thr Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu
                165                 170                 175
Pro Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg
            180                 185                 190
Lys Asn Asp
        195

<210> 1728
<211> 204
<212> PRT
<213> Homo sapiens

<400> 1728
Arg Gly Pro Thr Phe Thr Pro Glu Ile Met Ala Ala Glu Asp Val Val
 1               5                  10                  15
Ala Thr Gly Ala Asp Pro Ser Asp Leu Glu Ser Gly Gly Leu Leu His
            20                  25                  30
Glu Ile Phe Thr Ser Pro Leu Asn Leu Leu Leu Leu Gly Leu Cys Ile
        35                  40                  45
Phe Leu Leu Tyr Lys Ile Val Arg Gly Asp Gln Pro Ala Ala Ser Gly
    50                  55                  60
Asp Ser Asp Asp Asp Glu Pro Pro Pro Leu Pro Arg Leu Lys Arg Arg
65                  70                  75                  80
Asp Phe Thr Pro Ala Glu Leu Arg Arg Phe Asp Gly Val Gln Asp Pro
                85                  90                  95
Arg Ile Leu Met Ala Ile Asn Gly Lys Val Phe Asp Val Thr Lys Gly
            100                 105                 110
Arg Lys Phe Tyr Gly Pro Glu Gly Pro Tyr Gly Val Phe Ala Gly Arg
        115                 120                 125
Asp Ala Ser Arg Gly Leu Ala Thr Phe Cys Leu Asp Lys Glu Ala Leu
    130                 135                 140
Lys Asp Glu Tyr Asp Asp Leu Ser Asp Leu Thr Ala Ala Gln Gln Glu
145                 150                 155                 160
Thr Leu Ser Asp Trp Glu Ser Gln Phe Thr Phe Lys Tyr His His Val
                165                 170                 175
Gly Lys Leu Leu Lys Glu Gly Glu Glu Pro Thr Val Tyr Ser Asp Glu
            180                 185                 190
Glu Glu Pro Lys Asp Glu Ser Ala Arg Lys Asn Asp
        195                 200

<210> 1729
<211> 194
<212> PRT
<213> Homo sapiens

<400> 1729
Met Ala Ala Glu Asp Val Ala Ala Thr Gly Ala Asp Pro Ser Glu Leu
 1               5                  10                  15
Glu Gly Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu
            20                  25                  30
Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly
        35                  40                  45
Asp Gln Pro Ala Ala Ser Asp Ser Asp Asp Asp Glu Pro Pro Pro Leu
    50                  55                  60
Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg Phe
65                  70                  75                  80
Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys Val
                85                  90                  95
Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro Tyr
            100                 105                 110
Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe Cys
        115                 120                 125
Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp Leu
    130                 135                 140
Thr Pro Ala Gln Gln Glu Thr Leu Asn Asp Trp Asp Ser Gln Phe Thr
145                 150                 155                 160
Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu Pro
                165                 170                 175
Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg Lys
            180                 185                 190
Asn Asp


<210> 1730
<211> 220
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(220)
<223> Xaa = Any Amino Acid

<400> 1730
Met Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu
 1               5                  10                  15
Glu Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu
            20                  25                  30
Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly
        35                  40                  45
Asp Gln Pro Ala Ala Ser Gly Asp Arg Thr Thr Thr Xaa Pro Pro Pro
    50                  55                  60
Leu Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg
65                  70                  75                  80
Phe Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys
                85                  90                  95
Val Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro
            100                 105                 110
Tyr Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe
        115                 120                 125
Cys Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp
    130                 135                 140
Leu Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe
145                 150                 155                 160
Thr Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu
                165                 170                 175
Pro Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ser Arg
            180                 185                 190
Lys Asn Val Lys Ala Phe Ser Gly Ser Ile Ser Xaa Xaa Tyr Phe Ala
        195                 200                 205
Lys Ser Phe Val Thr Val His Xaa Val Phe Lys Thr
    210                 215                 220

<210> 1731
<211> 195
<212> PRT
<213> Homo sapiens

<400> 1731
Met Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu
 1               5                  10                  15
Glu Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu
            20                  25                  30
Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly
        35                  40                  45
Asp Gln Pro Ala Ala Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro
    50                  55                  60
Leu Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg
65                  70                  75                  80
Phe Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys
                85                  90                  95
Val Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro
            100                 105                 110
Tyr Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe
        115                 120                 125
Cys Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp
    130                 135                 140
Leu Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe
145                 150                 155                 160
Thr Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu
                165                 170                 175
Pro Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg
            180                 185                 190
Lys Asn Asp
        195

<210> 1732
<211> 195
<212> PRT
<213> Homo sapiens

<400> 1732
Met Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu
 1               5                  10                  15
Glu Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu
            20                  25                  30
Leu Leu Leu Gly Leu Cys Ile Ser Leu Leu Tyr Lys Ile Val Arg Gly
        35                  40                  45
Asp Gln Pro Ala Ala Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro
    50                  55                  60
Leu Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg
65                  70                  75                  80
Phe Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys
                85                  90                  95
Val Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro
            100                 105                 110
Tyr Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe
        115                 120                 125
Cys Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp
    130                 135                 140
Leu Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe
145                 150                 155                 160
Thr Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu
                165                 170                 175
Pro Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg
            180                 185                 190
Lys Asn Asp
        195

<210> 1733
<211> 195
<212> PRT
<213> Homo sapiens

<400> 1733
Met Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu
 1               5                  10                  15
Glu Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu
            20                  25                  30
Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly
        35                  40                  45
Asp Gln Pro Ala Ala Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro
    50                  55                  60
Leu Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg
65                  70                  75                  80
Phe Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys
                85                  90                  95
Val Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro
            100                 105                 110
Tyr Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe
        115                 120                 125
Cys Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp
    130                 135                 140
Leu Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe
145                 150                 155                 160
Thr Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu
                165                 170                 175
Pro Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg
            180                 185                 190
Lys Asn Asp
        195

<210> 1734
<211> 194
<212> PRT
<213> Homo sapiens

<400> 1734
Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu Glu
 1               5                  10                  15
Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu Leu
            20                  25                  30
Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly Asp
        35                  40                  45
Gln Pro Ala Ala Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro Leu
    50                  55                  60
Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg Phe
65                  70                  75                  80
Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys Val
                85                  90                  95
Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro Tyr
            100                 105                 110
Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe Cys
        115                 120                 125
Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp Leu
    130                 135                 140
Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe Thr
145                 150                 155                 160
Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu Pro
                165                 170                 175
Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg Lys
            180                 185                 190
Asn Asp


<210> 1735
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 1735
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Phe Ala Ala
            100                 105                 110
Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr
        115                 120                 125
Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val Lys His Met
    130                 135                 140
Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu
145                 150                 155                 160
Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu
                165                 170                 175
Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala
            180                 185                 190
Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln
        195                 200                 205
Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala
    210                 215                 220
Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu
225                 230                 235                 240
Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys
                245                 250                 255
Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser Gly Ile Ser
            260                 265                 270
Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val Gly Ala Lys
        275                 280                 285
Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp
    290                 295                 300
Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr
305                 310                 315                 320
Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu
                325                 330                 335
Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg Val Leu Leu
            340                 345                 350
Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val Gln Thr Ile
        355                 360                 365
His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val
    370                 375                 380
Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile Gly Ala Pro
385                 390                 395                 400
Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg
                405                 410                 415
Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly Asp Pro Gly
            420                 425                 430
Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile
        435                 440                 445
Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro Leu Glu Glu
    450                 455                 460
Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly Leu Ser Pro
465                 470                 475                 480
Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser Gly Ile Gln
                485                 490                 495
Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu Gly Asp Gly
            500                 505                 510
Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile Val Leu Ser
        515                 520                 525
Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe Ser Pro Ala
    530                 535                 540
Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys
545                 550                 555                 560
Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu
                565                 570                 575
Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu
            580                 585                 590
Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly
        595                 600                 605
Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser Met Ser Cys
    610                 615                 620
Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp Leu Ile Ser
625                 630                 635                 640
Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr
                645                 650                 655
Pro Arg Asp Gln Arg Ala Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro
            660                 665                 670
Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly
        675                 680                 685
Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala
    690                 695                 700
Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu
705                 710                 715                 720
Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp
                725                 730                 735
Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys
            740                 745                 750
Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser
        755                 760                 765
Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe
    770                 775                 780
Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe Asn Thr Leu Val
785                 790                 795                 800
Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala Asn Val Thr Cys
                805                 810                 815
Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile
            820                 825                 830
Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp
        835                 840                 845
Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln
    850                 855                 860
Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser Ile His Asp His
865                 870                 875                 880
Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser
                885                 890                 895
Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met Glu Pro Pro Val
            900                 905                 910
Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro
        915                 920                 925
Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val Phe Arg Gln Glu
    930                 935                 940
Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val Gly Glu Ile Glu
945                 950                 955                 960
Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser Ile Ser Phe Asn
                965                 970                 975
Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala Ser Leu Ala Gln
            980                 985                 990
Val Val Met Lys Val Asp Val Val Tyr Glu Lys Gln Met Leu Tyr Leu
        995                 1000                1005
Tyr Val Leu Ser Gly Ile Gly Gly Leu Leu Leu Leu Leu Leu Ile Phe
    1010                1015                1020
Ile Val Leu Tyr Lys Val Gly Phe Phe Lys Arg Asn Leu Lys Glu Lys
1025                1030                1035                1040
Met Glu Ala Gly Arg Gly Val Pro Asn Gly Ile Pro Ala Glu Asp Ser
                1045                1050                1055
Glu Gln Leu Ala Ser Gly Gln Glu Ala Gly Asp Pro Gly Cys Leu Lys
            1060                1065                1070
Pro Leu His Glu Lys Asp Ser Glu Ser Gly Gly Gly Lys Asp
        1075                1080                1085

<210> 1736
<211> 1223
<212> PRT
<213> Homo sapiens

<400> 1736
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp
            100                 105                 110
Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu
        115                 120                 125
Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg
    130                 135                 140
Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu
145                 150                 155                 160
Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu
                165                 170                 175
Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln
            180                 185                 190
Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe
        195                 200                 205
Ser Asp Tyr Val Lys Trp Lys Asp Pro Asp Ala Leu Leu Lys His Val
    210                 215                 220
Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val
225                 230                 235                 240
Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr
                245                 250                 255
Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn
            260                 265                 270
Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys
        275                 280                 285
His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser
    290                 295                 300
Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu
305                 310                 315                 320
Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly
                325                 330                 335
Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser
            340                 345                 350
Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val
        355                 360                 365
Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu
    370                 375                 380
Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg
385                 390                 395                 400
Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys
                405                 410                 415
Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg
            420                 425                 430
Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val
        435                 440                 445
Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu
    450                 455                 460
Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile
465                 470                 475                 480
Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile
                485                 490                 495
Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly
            500                 505                 510
Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu
        515                 520                 525
Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro
    530                 535                 540
Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly
545                 550                 555                 560
Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser
                565                 570                 575
Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu
            580                 585                 590
Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile
        595                 600                 605
Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe
    610                 615                 620
Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr
625                 630                 635                 640
Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile
                645                 650                 655
Lys Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr
            660                 665                 670
Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe
        675                 680                 685
Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser
    690                 695                 700
Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp
705                 710                 715                 720
Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu
                725                 730                 735
Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro
            740                 745                 750
Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu
        755                 760                 765
Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser
    770                 775                 780
Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser
785                 790                 795                 800
Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp
                805                 810                 815
Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val
            820                 825                 830
Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu
        835                 840                 845
Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser
    850                 855                 860
Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe
865                 870                 875                 880
Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala
                885                 890                 895
Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser
            900                 905                 910
Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln
        915                 920                 925
Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro
    930                 935                 940
Lys Ile His Gln Val Lys His Met Tyr Gln Gly Val His Gly Leu Val
945                 950                 955                 960
Glu Met Gln Thr Ser Lys Gln Ile Leu Cys Arg Pro Ala Gly Asp Ala
                965                 970                 975
Glu His Thr Val Gly Ala Gln Glu Gly Glu Leu Pro Cys Pro Trp Gly
            980                 985                 990
Val Ser Glu Ala Phe Arg Asp Asn Ile Arg Ala Gly Pro Cys Arg Val
        995                 1000                1005
Arg Ile Gln Pro Ser Ile His Asp His Asn Ile Pro Thr Leu Glu Ala
    1010                1015                1020
Val Val Gly Val Pro Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln
1025                1030                1035                1040
Trp Ser Val Gln Met Glu Pro Pro Val Pro Cys His Tyr Glu Asp Leu
                1045                1050                1055
Glu Arg Leu Pro Asp Ala Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe
            1060                1065                1070
Arg Cys Pro Val Val Phe Arg Gln Glu Ile Leu Val Gln Val Ile Gly
        1075                1080                1085
Thr Leu Glu Leu Val Gly Glu Ile Glu Ala Ser Ser Met Phe Ser Leu
    1090                1095                1100
Cys Ser Ser Leu Ser Ile Ser Phe Asn Ser Ser Lys His Phe His Leu
1105                1110                1115                1120
Tyr Gly Ser Asn Ala Ser Leu Ala Gln Val Val Met Lys Val Asp Val
                1125                1130                1135
Val Tyr Glu Lys Gln Met Leu Tyr Leu Tyr Val Leu Ser Gly Ile Gly
            1140                1145                1150
Gly Leu Leu Leu Leu Leu Leu Ile Phe Ile Val Leu Tyr Lys Val Gly
        1155                1160                1165
Phe Phe Lys Arg Asn Leu Lys Glu Lys Met Glu Ala Gly Arg Gly Val
    1170                1175                1180
Pro Asn Gly Ile Pro Ala Glu Asp Ser Glu Gln Leu Ala Ser Gly Gln
1185                1190                1195                1200
Glu Ala Gly Asp Pro Gly Cys Leu Lys Pro Leu His Glu Lys Asp Ser
                1205                1210                1215
Glu Ser Gly Gly Gly Lys Asp
            1220

<210> 1737
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 1737
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp
            100                 105                 110
Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu
        115                 120                 125
Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg
    130                 135                 140
Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu
145                 150                 155                 160
Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu
                165                 170                 175
Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln
            180                 185                 190
Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe
        195                 200                 205
Ser Asp Tyr Val Lys Trp Lys Asp Pro Asp Ala Leu Leu Lys His Val
    210                 215                 220
Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val
225                 230                 235                 240
Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr
                245                 250                 255
Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn
            260                 265                 270
Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys
        275                 280                 285
His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser
    290                 295                 300
Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu
305                 310                 315                 320
Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly
                325                 330                 335
Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser
            340                 345                 350
Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val
        355                 360                 365
Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu
    370                 375                 380
Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg
385                 390                 395                 400
Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys
                405                 410                 415
Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg
            420                 425                 430
Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val
        435                 440                 445
Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu
    450                 455                 460
Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile
465                 470                 475                 480
Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile
                485                 490                 495
Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly
            500                 505                 510
Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu
        515                 520                 525
Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro
    530                 535                 540
Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly
545                 550                 555                 560
Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser
                565                 570                 575
Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu
            580                 585                 590
Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile
        595                 600                 605
Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe
    610                 615                 620
Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr
625                 630                 635                 640
Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile
                645                 650                 655
Lys Ser Leu Tyr Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr
            660                 665                 670
Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe
        675                 680                 685
Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser
    690                 695                 700
Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp
705                 710                 715                 720
Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu
                725                 730                 735
Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro
            740                 745                 750
Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu
        755                 760                 765
Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser
    770                 775                 780
Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser
785                 790                 795                 800
Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp
                805                 810                 815
Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val
            820                 825                 830
Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu
        835                 840                 845
Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser
    850                 855                 860
Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe
865                 870                 875                 880
Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala
                885                 890                 895
Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser
            900                 905                 910
Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln
        915                 920                 925
Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro
    930                 935                 940
Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser
945                 950                 955                 960
Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro
                965                 970                 975
Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met
            980                 985                 990
Glu Pro Pro Val Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp
        995                 1000                1005
Ala Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val
    1010                1015                1020
Phe Arg Gln Glu Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val
1025                1030                1035                1040
Gly Glu Ile Glu Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser
                1045                1050                1055
Ile Ser Phe Asn Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala
            1060                1065                1070
Ser Leu Ala Gln Val Val Met Lys Val Asp Val Val Tyr Glu Lys Gln
        1075                1080                1085
Met Leu Tyr Leu Tyr Val Leu Ser Gly Ile Gly Gly Leu Leu Leu Leu
    1090                1095                1100
Leu Leu Ile Phe Ile Val Leu Tyr Lys Val Gly Phe Phe Lys Arg Asn
1105                1110                1115                1120
Leu Lys Glu Lys Met Glu Ala Gly Arg Gly Val Pro Asn Gly Ile Pro
                1125                1130                1135
Ala Glu Asp Ser Glu Gln Leu Ala Ser Gly Gln Glu Ala Gly Asp Pro
            1140                1145                1150
Gly Cys Leu Lys Pro Leu His Glu Lys Asp Ser Glu Ser Gly Gly Gly
        1155                1160                1165
Lys Asp
    1170

<210> 1738
<211> 1145
<212> PRT
<213> Homo sapiens

<400> 1738
Tyr Asn Leu Asp Val Arg Gly Ala Arg Ser Phe Ser Pro Pro Arg Ala
 1               5                  10                  15
Gly Arg His Phe Gly Tyr Arg Val Leu Gln Val Gly Asn Gly Val Ile
            20                  25                  30
Val Gly Ala Pro Gly Glu Gly Asn Ser Thr Gly Ser Leu Tyr Gln Cys
        35                  40                  45
Gln Ser Gly Thr Gly His Cys Leu Pro Val Thr Leu Arg Gly Ser Asn
    50                  55                  60
Tyr Thr Ser Lys Tyr Leu Gly Met Thr Leu Ala Thr Asp Pro Thr Asp
65                  70                  75                  80
Gly Ser Ile Leu Ala Cys Asp Pro Gly Leu Ser Arg Thr Cys Asp Gln
                85                  90                  95
Asn Thr Tyr Leu Ser Gly Leu Cys Tyr Leu Phe Arg Gln Asn Leu Gln
            100                 105                 110
Gly Pro Met Leu Gln Gly Arg Pro Gly Phe Gln Glu Cys Ile Lys Gly
        115                 120                 125
Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu Gln Pro
    130                 135                 140
Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys Lys
145                 150                 155                 160
Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr Ser
                165                 170                 175
Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Trp Lys Asp Pro
            180                 185                 190
Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn Thr
        195                 200                 205
Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu Leu
    210                 215                 220
Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Asp Gly
225                 230                 235                 240
Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile Arg
                245                 250                 255
Tyr Ile Ile Gly Ile Gly Lys His Phe Gln Thr Lys Glu Ser Gln Glu
            260                 265                 270
Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys Ile
        275                 280                 285
Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln Lys
    290                 295                 300
Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys Gln Asp Leu Thr Ser Phe
305                 310                 315                 320
Asn Met Glu Leu Ser Ser Ser Gly Ile Ser Ala Asp Leu Ser Arg Gly
                325                 330                 335
His Ala Val Val Gly Ala Val Gly Ala Lys Asp Trp Ala Gly Gly Phe
            340                 345                 350
Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp Thr Phe Ile Gly Asn Glu
        355                 360                 365
Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr Leu Gly Tyr Thr Val Thr
    370                 375                 380
Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu Leu Ala Ser Gly Ala Pro
385                 390                 395                 400
Arg Tyr Gln His Met Gly Arg Val Leu Leu Phe Gln Glu Pro Gln Gly
                405                 410                 415
Gly Gly His Trp Ser Gln Val Gln Thr Ile His Gly Thr Gln Ile Gly
            420                 425                 430
Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val Asp Val Asp Gln Asp Gly
        435                 440                 445
Glu Thr Glu Leu Leu Leu Ile Gly Ala Pro Leu Phe Tyr Gly Glu Gln
    450                 455                 460
Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg Arg Gln Leu Gly Phe Glu
465                 470                 475                 480
Glu Val Ser Glu Leu Gln Gly Asp Pro Gly Tyr Pro Leu Gly Arg Phe
                485                 490                 495
Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile Asn Gly Asp Gly Leu Val
            500                 505                 510
Asp Val Ala Val Gly Ala Pro Leu Glu Glu Gln Gly Ala Val Tyr Ile
        515                 520                 525
Phe Asn Gly Arg His Gly Gly Leu Ser Pro Gln Pro Ser Gln Arg Ile
    530                 535                 540
Glu Gly Thr Gln Val Leu Ser Gly Ile Gln Trp Phe Gly Arg Ser Ile
545                 550                 555                 560
His Gly Val Lys Asp Leu Glu Gly Asp Gly Leu Ala Asp Val Ala Val
                565                 570                 575
Gly Ala Glu Ser Gln Met Ile Val Leu Ser Ser Arg Pro Val Val Asp
            580                 585                 590
Met Val Thr Leu Met Ser Phe Ser Pro Ala Glu Ile Pro Val His Glu
        595                 600                 605
Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys Met Lys Glu Gly Val Asn
    610                 615                 620
Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu Tyr Pro Gln Phe Gln Gly
625                 630                 635                 640
Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu Gln Leu Asp Gly His Arg
                645                 650                 655
Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly Arg His Glu Leu Arg Arg
            660                 665                 670
Asn Ile Ala Val Thr Thr Ser Met Ser Cys Thr Asp Phe Ser Phe His
        675                 680                 685
Phe Pro Val Cys Val Gln Asp Leu Ile Ser Pro Ile Asn Val Ser Leu
    690                 695                 700
Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr Pro Arg Asp Gln Arg Ala
705                 710                 715                 720
Gln Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro Ser Leu His Ser Glu
                725                 730                 735
Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly Glu Asp Lys Lys Cys
            740                 745                 750
Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala Arg Ser Arg Ala Leu
        755                 760                 765
Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu Leu Ser Leu Ser Asn
    770                 775                 780
Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp Leu His Phe Pro Pro
785                 790                 795                 800
Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys Pro His Ser Gln Ile
                805                 810                 815
Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser Arg Leu Leu Ser Arg
            820                 825                 830
Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe Lys Ala Gly His Ser
        835                 840                 845
Val Ala Leu Gln Met Met Phe Asn Thr Leu Val Asn Ser Ser Trp Gly
    850                 855                 860
Asp Ser Val Glu Leu His Ala Asn Val Thr Cys Asn Asn Glu Asp Ser
865                 870                 875                 880
Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile Ile Pro Ile Leu Tyr
                885                 890                 895
Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp Ser Thr Leu Tyr Val
            900                 905                 910
Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln Val Lys His Met Tyr
        915                 920                 925
Gln Val Arg Ile Gln Pro Ser Ile His Asp His Asn Ile Pro Thr Leu
    930                 935                 940
Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser Glu Gly Pro Ile Thr
945                 950                 955                 960
His Gln Trp Ser Val Gln Met Glu Pro Pro Val Pro Cys His Tyr Glu
                965                 970                 975
Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro Cys Leu Pro Gly Ala
            980                 985                 990
Leu Phe Arg Cys Pro Val Val Phe Arg Gln Glu Ile Leu Val Gln Val
        995                 1000                1005
Ile Gly Thr Leu Glu Leu Val Gly Glu Ile Glu Ala Ser Ser Met Phe
    1010                1015                1020
Ser Leu Cys Ser Ser Leu Ser Ile Ser Phe Asn Ser Ser Lys His Phe
1025                1030                1035                1040
His Leu Tyr Gly Ser Asn Ala Ser Leu Ala Gln Val Val Met Lys Val
                1045                1050                1055
Asp Val Val Tyr Glu Lys Gln Met Leu Tyr Leu Tyr Val Leu Ser Gly
            1060                1065                1070
Ile Gly Gly Leu Leu Leu Leu Leu Leu Ile Phe Ile Val Leu Tyr Lys
        1075                1080                1085
Val Gly Phe Phe Lys Arg Asn Leu Lys Glu Lys Met Glu Ala Gly Arg
    1090                1095                1100
Gly Val Pro Asn Gly Ile Pro Ala Glu Asp Ser Glu Gln Leu Ala Ser
1105                1110                1115                1120
Gly Gln Glu Ala Gly Asp Pro Gly Cys Leu Lys Pro Leu His Glu Lys
                1125                1130                1135
Asp Ser Glu Ser Gly Gly Gly Lys Asp
            1140                1145

<210> 1739
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 1739
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp
            100                 105                 110
Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu
        115                 120                 125
Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg
    130                 135                 140
Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu
145                 150                 155                 160
Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu
                165                 170                 175
Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln
            180                 185                 190
Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe
        195                 200                 205
Ser Asp Tyr Val Lys Trp Lys Asp Pro Asp Ala Leu Leu Lys His Val
    210                 215                 220
Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val
225                 230                 235                 240
Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr
                245                 250                 255
Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn
            260                 265                 270
Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys
        275                 280                 285
His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser
    290                 295                 300
Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu
305                 310                 315                 320
Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly
                325                 330                 335
Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser
            340                 345                 350
Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val
        355                 360                 365
Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu
    370                 375                 380
Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg
385                 390                 395                 400
Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys
                405                 410                 415
Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg
            420                 425                 430
Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val
        435                 440                 445
Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu
    450                 455                 460
Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile
465                 470                 475                 480
Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile
                485                 490                 495
Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly
            500                 505                 510
Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu
        515                 520                 525
Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro
    530                 535                 540
Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly
545                 550                 555                 560
Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser
                565                 570                 575
Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu
            580                 585                 590
Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile
        595                 600                 605
Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe
    610                 615                 620
Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr
625                 630                 635                 640
Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile
                645                 650                 655
Lys Ser Leu Tyr Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr
            660                 665                 670
Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe
        675                 680                 685
Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser
    690                 695                 700
Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp
705                 710                 715                 720
Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu
                725                 730                 735
Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro
            740                 745                 750
Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu
        755                 760                 765
Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser
    770                 775                 780
Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser
785                 790                 795                 800
Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp
                805                 810                 815
Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val
            820                 825                 830
Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu
        835                 840                 845
Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser
    850                 855                 860
Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe
865                 870                 875                 880
Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala
                885                 890                 895
Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser
            900                 905                 910
Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln
        915                 920                 925
Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro
    930                 935                 940
Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser
945                 950                 955                 960
Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro
                965                 970                 975
Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met
            980                 985                 990
Glu Pro Pro Val Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp
        995                 1000                1005
Ala Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val
    1010                1015                1020
Phe Arg Gln Glu Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val
1025                1030                1035                1040
Gly Glu Ile Glu Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser
                1045                1050                1055
Ile Ser Phe Asn Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala
            1060                1065                1070
Ser Leu Ala Gln Val Val Met Lys Val Asp Val Val Tyr Glu Lys Gln
        1075                1080                1085
Met Leu Tyr Leu Tyr Val Leu Ser Gly Ile Gly Gly Leu Leu Leu Leu
    1090                1095                1100
Leu Leu Ile Phe Ile Val Leu Tyr Lys Val Gly Phe Phe Lys Arg Asn
1105                1110                1115                1120
Leu Lys Glu Lys Met Glu Ala Gly Arg Gly Val Pro Asn Gly Ile Pro
                1125                1130                1135
Ala Glu Asp Ser Glu Gln Leu Ala Ser Gly Gln Glu Ala Gly Asp Pro
            1140                1145                1150
Gly Cys Leu Lys Pro Leu His Glu Lys Asp Ser Glu Ser Gly Gly Gly
        1155                1160                1165
Lys Asp
    1170

<210> 1740
<211> 1065
<212> PRT
<213> Homo sapiens

<400> 1740
Tyr Asn Leu Asp Val Arg Gly Ala Arg Ser Phe Ser Pro Pro Arg Ala
 1               5                  10                  15
Gly Arg His Phe Gly Tyr Arg Val Leu Gln Val Gly Asn Gly Val Ile
            20                  25                  30
Val Gly Ala Pro Gly Glu Gly Asn Ser Thr Gly Ser Leu Tyr Gln Cys
        35                  40                  45
Gln Ser Gly Thr Gly His Cys Leu Pro Val Thr Leu Arg Gly Ser Asn
    50                  55                  60
Tyr Thr Ser Lys Tyr Leu Gly Met Thr Leu Ala Thr Asp Pro Thr Asp
65                  70                  75                  80
Gly Ser Ile Leu Ala Cys Asp Pro Gly Leu Ser Arg Thr Cys Asp Gln
                85                  90                  95
Asn Thr Tyr Leu Ser Gly Leu Cys Tyr Leu Phe Arg Gln Asn Leu Gln
            100                 105                 110
Gly Pro Met Leu Gln Gly Arg Pro Gly Phe Gln Glu Cys Ile Lys Gly
        115                 120                 125
Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu Gln Pro
    130                 135                 140
Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met Lys Lys
145                 150                 155                 160
Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser Thr Ser
                165                 170                 175
Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Trp Lys Asp Pro
            180                 185                 190
Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr Asn Thr
        195                 200                 205
Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu Glu Leu
    210                 215                 220
Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr Asp Gly
225                 230                 235                 240
Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile Ile Arg
                245                 250                 255
Tyr Ile Ile Gly Ile Gly Lys His Phe Gln Thr Lys Glu Ser Gln Glu
            260                 265                 270
Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val Lys Ile
        275                 280                 285
Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu Gln Lys
    290                 295                 300
Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys Gln Asp Leu Thr Ser Phe
305                 310                 315                 320
Asn Met Glu Leu Ser Ser Ser Gly Ile Ser Ala Asp Leu Ser Arg Gly
                325                 330                 335
His Ala Val Val Gly Ala Val Gly Ala Lys Asp Trp Ala Gly Gly Phe
            340                 345                 350
Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp Thr Phe Ile Gly Asn Glu
        355                 360                 365
Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr Leu Gly Tyr Thr Val Thr
    370                 375                 380
Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu Leu Ala Ser Gly Ala Pro
385                 390                 395                 400
Arg Tyr Gln His Met Gly Arg Val Leu Leu Phe Gln Glu Pro Gln Gly
                405                 410                 415
Gly Gly His Trp Ser Gln Val Gln Thr Ile His Gly Thr Gln Ile Gly
            420                 425                 430
Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val Asp Val Asp Gln Asp Gly
        435                 440                 445
Glu Thr Glu Leu Leu Leu Leu Ile Gly Ala Pro Leu Phe Tyr Gly Glu
    450                 455                 460
Gln Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg Arg Gln Leu Gly Phe
465                 470                 475                 480
Glu Glu Val Ser Glu Leu Gln Gly Asp Pro Gly Tyr Pro Leu Gly Arg
                485                 490                 495
Phe Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile Asn Gly Asp Gly Leu
            500                 505                 510
Val Asp Val Ala Val Gly Ala Pro Leu Glu Glu Gln Gly Ala Val Tyr
        515                 520                 525
Ile Phe Asn Gly Arg His Gly Gly Leu Ser Pro Gln Pro Ser Gln Arg
    530                 535                 540
Ile Glu Gly Thr Gln Val Leu Ser Gly Ile Gln Trp Phe Gly Arg Ser
545                 550                 555                 560
Ile His Gly Val Lys Asp Leu Glu Gly Asp Gly Leu Ala Asp Val Ala
                565                 570                 575
Val Gly Ala Glu Ser Gln Met Ile Val Leu Ser Ser Arg Pro Val Val
            580                 585                 590
Asp Met Val Thr Leu Met Ser Phe Ser Pro Ala Glu Ile Pro Val His
        595                 600                 605
Glu Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys Met Lys Glu Gly Val
    610                 615                 620
Asn Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu Tyr Pro Gln Phe Gln
625                 630                 635                 640
Gly Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu Gln Leu Asp Gly His
                645                 650                 655
Arg Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly Arg His Glu Leu Arg
            660                 665                 670
Arg Asn Ile Ala Val Thr Thr Ser Met Ser Cys Thr Asp Phe Ser Phe
        675                 680                 685
His Phe Pro Val Cys Val Gln Asp Leu Ile Ser Pro Ile Asn Val Ser
    690                 695                 700
Leu Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr Pro Arg Asp Gln Arg
705                 710                 715                 720
Ala Gln Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro Ser Leu His Ser
                725                 730                 735
Glu Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly Glu Asp Lys Lys
            740                 745                 750
Cys Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala Arg Ser Arg Ala
        755                 760                 765
Leu Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu Leu Ser Leu Ser
    770                 775                 780
Asn Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp Leu His Phe Pro
785                 790                 795                 800
Pro Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys Pro His Ser Gln
                805                 810                 815
Ile Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser Arg Leu Leu Ser
            820                 825                 830
Arg Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe Lys Ala Gly His
        835                 840                 845
Ser Val Ala Leu Gln Met Asn Phe Asn Thr Leu Val Asn Ser Ser Trp
    850                 855                 860
Gly Asp Ser Val Glu Leu His Ala Asn Val Thr Cys Asn Asn Glu Asp
865                 870                 875                 880
Ser Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile Ile Pro Ile Leu
                885                 890                 895
Tyr Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp Ser Thr Leu Tyr
            900                 905                 910
Val Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln Val Lys His Met
        915                 920                 925
Tyr Gln Val Arg Ile Gln Pro Ser Ile His Asp His Asn Ile Pro Thr
    930                 935                 940
Leu Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser Glu Gly Pro Ile
945                 950                 955                 960
Thr His Gln Trp Ser Val Gln Met Glu Pro Pro Tyr Pro Cys His Tyr
                965                 970                 975
Glu Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro Cys Leu Pro Gly
            980                 985                 990
Ala Leu Phe Arg Cys Pro Val Val Phe Arg Gln Glu Ile Leu Val Gln
        995                 1000                1005
Val Ile Gly Thr Leu Glu Leu Val Gly Glu Ile Glu Ala Ser Ser Met
    1010                1015                1020
Phe Ser Leu Cys Ser Ser Leu Ser Ile Ser Phe Asn Ser Ser Lys His
1025                1030                1035                1040
Phe His Leu Tyr Gly Ser Asn Ala Ser Leu Ala Gln Val Val Met Lys
                1045                1050                1055
Val Asp Val Val Tyr Glu Lys Gln Met
            1060                1065

<210> 1741
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 1741
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp
            100                 105                 110
Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu
        115                 120                 125
Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg
    130                 135                 140
Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu
145                 150                 155                 160
Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu
                165                 170                 175
Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln
            180                 185                 190
Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe
        195                 200                 205
Ser Asp Tyr Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val
    210                 215                 220
Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val
225                 230                 235                 240
Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr
                245                 250                 255
Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn
            260                 265                 270
Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys
        275                 280                 285
His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser
    290                 295                 300
Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu
305                 310                 315                 320
Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly
                325                 330                 335
Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser
            340                 345                 350
Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val
        355                 360                 365
Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu
    370                 375                 380
Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg
385                 390                 395                 400
Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys
                405                 410                 415
Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg
            420                 425                 430
Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val
        435                 440                 445
Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu
    450                 455                 460
Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile
465                 470                 475                 480
Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile
                485                 490                 495
Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly
            500                 505                 510
Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu
        515                 520                 525
Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro
    530                 535                 540
Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly
545                 550                 555                 560
Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser
                565                 570                 575
Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu
            580                 585                 590
Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile
        595                 600                 605
Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe
    610                 615                 620
Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr
625                 630                 635                 640
Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile
                645                 650                 655
Lys Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr
            660                 665                 670
Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe
        675                 680                 685
Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser
    690                 695                 700
Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp
705                 710                 715                 720
Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu
                725                 730                 735
Glu Gly Thr Pro Arg Asp Gln Arg Ala Gly Lys Asp Ile Pro Pro Ile
            740                 745                 750
Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu Lys
        755                 760                 765
Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser Phe
    770                 775                 780
Ser Pro Ala Arg Ser Thr Ala Leu Arg Leu Thr Ala Phe Ala Ser Leu
785                 790                 795                 800
Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp Val
                805                 810                 815
Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val Glu
            820                 825                 830
Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu Pro
        835                 840                 845
Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser Ser
    850                 855                 860
Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe Asn
865                 870                 875                 880
Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala Asn
                885                 890                 895
Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser Ala
            900                 905                 910
Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln Asp
        915                 920                 925
Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro Lys
    930                 935                 940
Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser Ile
945                 950                 955                 960
His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro Gln
                965                 970                 975
Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met Glu
            980                 985                 990
Pro Pro Val Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp Ala
        995                 1000                1005
Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val Phe
    1010                1015                1020
Arg Gln Glu Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val Gly
1025                1030                1035                1040
Glu Ile Glu Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser Ile
                1045                1050                1055
Ser Phe Asn Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala Ser
            1060                1065                1070
Leu Ala Gln Val Val Met Lys Val Asp Val Val Tyr Glu Lys
        1075                1080                1085

<210> 1742
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 1742
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp
            100                 105                 110
Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu
        115                 120                 125
Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg
    130                 135                 140
Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu
145                 150                 155                 160
Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu
                165                 170                 175
Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln
            180                 185                 190
Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe
        195                 200                 205
Ser Asp Tyr Val Lys Trp Lys Asp Pro Asp Ala Leu Leu Lys His Val
    210                 215                 220
Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val
225                 230                 235                 240
Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr
                245                 250                 255
Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn
            260                 265                 270
Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys
        275                 280                 285
His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser
    290                 295                 300
Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu
305                 310                 315                 320
Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly
                325                 330                 335
Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser
            340                 345                 350
Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val
        355                 360                 365
Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu
    370                 375                 380
Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg
385                 390                 395                 400
Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys
                405                 410                 415
Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg
            420                 425                 430
Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val
        435                 440                 445
Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu
    450                 455                 460
Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile
465                 470                 475                 480
Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile
                485                 490                 495
Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly
            500                 505                 510
Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu
        515                 520                 525
Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro
    530                 535                 540
Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly
545                 550                 555                 560
Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser
                565                 570                 575
Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu
            580                 585                 590
Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile
        595                 600                 605
Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe
    610                 615                 620
Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr
625                 630                 635                 640
Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile
                645                 650                 655
Lys Ser Leu Tyr Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr
            660                 665                 670
Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe
        675                 680                 685
Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser
    690                 695                 700
Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp
705                 710                 715                 720
Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu
                725                 730                 735
Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro
            740                 745                 750
Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu
        755                 760                 765
Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser
    770                 775                 780
Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser
785                 790                 795                 800
Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp
                805                 810                 815
Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val
            820                 825                 830
Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu
        835                 840                 845
Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser
    850                 855                 860
Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe
865                 870                 875                 880
Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala
                885                 890                 895
Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser
            900                 905                 910
Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln
        915                 920                 925
Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro
    930                 935                 940
Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser
945                 950                 955                 960
Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro
                965                 970                 975
Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met
            980                 985                 990
Glu Pro Pro Val Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp
        995                 1000                1005
Ala Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val
    1010                1015                1020
Phe Arg Gln Glu Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val
1025                1030                1035                1040
Gly Glu Ile Glu Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser
                1045                1050                1055
Ile Ser Phe Asn Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala
            1060                1065                1070
Ser Leu Ala Gln Val Val Met Lys Val Asp Val Val Tyr Glu Lys Gln
        1075                1080                1085
Met Leu Tyr Leu Tyr Val Leu Ser Gly Ile Gly Gly Leu Leu Leu Leu
    1090                1095                1100
Leu Leu Ile Phe Ile Val Leu Tyr Lys Val Gly Phe Phe Lys Arg Asn
1105                1110                1115                1120
Leu Lys Glu Lys Met Glu Ala Gly Arg Gly Val Pro Asn Gly Ile Pro
                1125                1130                1135
Ala Glu Asp Ser Glu Gln Leu Ala Ser Gly Gln Glu Ala Gly Asp Pro
            1140                1145                1150
Gly Cys Leu Lys Pro Leu His Glu Lys Asp Ser Glu Ser Gly Gly Gly
        1155                1160                1165
Lys Asp
    1170

<210> 1743
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 1743
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp
            100                 105                 110
Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu
        115                 120                 125
Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg
    130                 135                 140
Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu
145                 150                 155                 160
Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu
                165                 170                 175
Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln
            180                 185                 190
Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe
        195                 200                 205
Ser Asp Tyr Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val
    210                 215                 220
Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val
225                 230                 235                 240
Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr
                245                 250                 255
Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn
            260                 265                 270
Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys
        275                 280                 285
His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser
    290                 295                 300
Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu
305                 310                 315                 320
Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly
                325                 330                 335
Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser
            340                 345                 350
Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val
        355                 360                 365
Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu
    370                 375                 380
Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg
385                 390                 395                 400
Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys
                405                 410                 415
Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg
            420                 425                 430
Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val
        435                 440                 445
Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu
    450                 455                 460
Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile
465                 470                 475                 480
Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile
                485                 490                 495
Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly
            500                 505                 510
Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu
        515                 520                 525
Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro
    530                 535                 540
Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly
545                 550                 555                 560
Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser
                565                 570                 575
Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu
            580                 585                 590
Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile
        595                 600                 605
Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe
    610                 615                 620
Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr
625                 630                 635                 640
Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile
                645                 650                 655
Lys Ser Leu Tyr Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr
            660                 665                 670
Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe
        675                 680                 685
Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser
    690                 695                 700
Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp
705                 710                 715                 720
Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu
                725                 730                 735
Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro
            740                 745                 750
Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu
        755                 760                 765
Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser
    770                 775                 780
Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser
785                 790                 795                 800
Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp
                805                 810                 815
Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val
            820                 825                 830
Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu
        835                 840                 845
Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser
    850                 855                 860
Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe
865                 870                 875                 880
Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala
                885                 890                 895
Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser
            900                 905                 910
Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln
        915                 920                 925
Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro
    930                 935                 940
Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser
945                 950                 955                 960
Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro
                965                 970                 975
Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met
            980                 985                 990
Glu Pro Pro Val Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp
        995                 1000                1005
Ala Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val
    1010                1015                1020
Phe Arg Gln Glu Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val
1025                1030                1035                1040
Gly Glu Ile Glu Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser
                1045                1050                1055
Ile Ser Phe Asn Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala
            1060                1065                1070
Ser Leu Ala Gln Val Val Met Lys Val Asp Val Val Tyr Glu Lys Gln
        1075                1080                1085
Met Leu Tyr Leu Tyr Val Leu Ser Gly Ile Gly Gly Leu Leu Leu Leu
    1090                1095                1100
Leu Leu Ile Phe Ile Val Leu Tyr Lys Val Gly Phe Phe Lys Arg Asn
1105                1110                1115                1120
Leu Lys Glu Lys Met Glu Ala Gly Arg Gly Val Pro Asn Gly Ile Pro
                1125                1130                1135
Ala Glu Asp Ser Glu Gln Leu Ala Ser Gly Gln Glu Ala Gly Asp Pro
            1140                1145                1150
Gly Cys Leu Lys Pro Leu His Glu Lys Asp Ser Glu Ser Gly Gly Gly
        1155                1160                1165
Lys Asp
    1170

<210> 1744
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 1744
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Phe Ala Ala
            100                 105                 110
Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr
        115                 120                 125
Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val Lys His Met
    130                 135                 140
Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu
145                 150                 155                 160
Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu
                165                 170                 175
Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala
            180                 185                 190
Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln
        195                 200                 205
Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala
    210                 215                 220
Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu
225                 230                 235                 240
Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys
                245                 250                 255
Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser Gly Ile Ser
            260                 265                 270
Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val Gly Ala Lys
        275                 280                 285
Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp
    290                 295                 300
Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr
305                 310                 315                 320
Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu
                325                 330                 335
Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg Val Leu Leu
            340                 345                 350
Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val Gln Thr Ile
        355                 360                 365
His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val
    370                 375                 380
Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile Gly Ala Pro
385                 390                 395                 400
Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg
                405                 410                 415
Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly Asp Pro Gly
            420                 425                 430
Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile
        435                 440                 445
Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro Leu Glu Glu
    450                 455                 460
Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly Leu Ser Pro
465                 470                 475                 480
Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser Gly Ile Gln
                485                 490                 495
Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu Gly Asp Gly
            500                 505                 510
Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile Val Leu Ser
        515                 520                 525
Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe Ser Pro Ala
    530                 535                 540
Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys
545                 550                 555                 560
Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu
                565                 570                 575
Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu
            580                 585                 590
Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly
        595                 600                 605
Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser Met Ser Cys
    610                 615                 620
Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp Leu Ile Ser
625                 630                 635                 640
Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr
                645                 650                 655
Pro Arg Asp Gln Arg Ala Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro
            660                 665                 670
Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly
        675                 680                 685
Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala
    690                 695                 700
Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu
705                 710                 715                 720
Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp
                725                 730                 735
Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys
            740                 745                 750
Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser
        755                 760                 765
Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe
    770                 775                 780
Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe Asn Thr Leu Val
785                 790                 795                 800
Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala Asn Val Thr Cys
                805                 810                 815
Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile
            820                 825                 830
Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp
        835                 840                 845
Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln
    850                 855                 860
Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser Ile His Asp His
865                 870                 875                 880
Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser
                885                 890                 895
Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met Glu Pro Pro Val
            900                 905                 910
Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro
        915                 920                 925
Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val Phe Arg Gln Glu
    930                 935                 940
Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val Gly Glu Ile Glu
945                 950                 955                 960
Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser Ile Ser Phe Asn
                965                 970                 975
Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala Ser Leu Ala Gln
            980                 985                 990
Val Val Met Lys Val Asp Val Val Tyr Glu Lys Gln Met Leu Tyr Leu
        995                 1000                1005
Tyr Val Leu Ser Gly Ile Gly Gly Leu Leu Leu Leu Leu Leu Ile Phe
    1010                1015                1020
Ile Val Leu Tyr Lys Val Gly Phe Phe Lys Arg Asn Leu Lys Glu Lys
1025                1030                1035                1040
Met Glu Ala Gly Arg Gly Val Pro Asn Gly Ile Pro Ala Glu Asp Ser
                1045                1050                1055
Glu Gln Leu Ala Ser Gly Gln Glu Ala Gly Asp Pro Gly Cys Leu Lys
            1060                1065                1070
Pro Leu His Glu Lys Asp Ser Glu Ser Gly Gly Gly Lys Asp
        1075                1080                1085

<210> 1745
<211> 824
<212> PRT
<213> Homo sapiens

<400> 1745
Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu
 1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu
            20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser
        35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr
    50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys
65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val
                85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln
            100                 105                 110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu
        115                 120                 125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly
    130                 135                 140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys
145                 150                 155                 160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser
                165                 170                 175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu
            180                 185                 190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu
        195                 200                 205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr
    210                 215                 220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly
225                 230                 235                 240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp
                245                 250                 255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe
            260                 265                 270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro
        275                 280                 285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr
    290                 295                 300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln
305                 310                 315                 320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His
                325                 330                 335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr
            340                 345                 350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala
        355                 360                 365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu
    370                 375                 380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp
385                 390                 395                 400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp
                405                 410                 415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys
            420                 425                 430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys
        435                 440                 445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser
    450                 455                 460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn
465                 470                 475                 480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu
                485                 490                 495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val
            500                 505                 510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu
        515                 520                 525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly
    530                 535                 540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn
545                 550                 555                 560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly
                565                 570                 575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala
            580                 585                 590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser
        595                 600                 605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu
    610                 615                 620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys
625                 630                 635                 640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile
                645                 650                 655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile
            660                 665                 670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser
        675                 680                 685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser
    690                 695                 700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp
705                 710                 715                 720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro
                725                 730                 735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro
            740                 745                 750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr
        755                 760                 765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn
    770                 775                 780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val
785                 790                 795                 800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg
                805                 810                 815
Val Asp Ser Lys Glu Thr Glu Cys
            820

<210> 1746
<211> 824
<212> PRT
<213> Homo sapiens

<400> 1746
Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu
 1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu
            20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser
        35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr
    50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys
65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val
                85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln
            100                 105                 110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu
        115                 120                 125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly
    130                 135                 140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys
145                 150                 155                 160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser
                165                 170                 175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu
            180                 185                 190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu
        195                 200                 205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr
    210                 215                 220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly
225                 230                 235                 240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp
                245                 250                 255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe
            260                 265                 270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro
        275                 280                 285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr
    290                 295                 300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln
305                 310                 315                 320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His
                325                 330                 335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr
            340                 345                 350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala
        355                 360                 365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu
    370                 375                 380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp
385                 390                 395                 400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp
                405                 410                 415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys
            420                 425                 430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys
        435                 440                 445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser
    450                 455                 460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn
465                 470                 475                 480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu
                485                 490                 495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val
            500                 505                 510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu
        515                 520                 525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly
    530                 535                 540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn
545                 550                 555                 560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly
                565                 570                 575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala
            580                 585                 590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser
        595                 600                 605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu
    610                 615                 620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys
625                 630                 635                 640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile
                645                 650                 655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile
            660                 665                 670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser
        675                 680                 685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser
    690                 695                 700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp
705                 710                 715                 720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro
                725                 730                 735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro
            740                 745                 750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr
        755                 760                 765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn
    770                 775                 780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val
785                 790                 795                 800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg
                805                 810                 815
Val Asp Ser Lys Glu Thr Glu Cys
            820

<210> 1747
<211> 824
<212> PRT
<213> Homo sapiens

<400> 1747
Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu
 1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu
            20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser
        35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr
    50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys
65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val
                85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Ala Lys Trp Gln
            100                 105                 110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu
        115                 120                 125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly
    130                 135                 140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys
145                 150                 155                 160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser
                165                 170                 175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu
            180                 185                 190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu
        195                 200                 205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr
    210                 215                 220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly
225                 230                 235                 240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp
                245                 250                 255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe
            260                 265                 270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro
        275                 280                 285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr
    290                 295                 300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln
305                 310                 315                 320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His
                325                 330                 335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr
            340                 345                 350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala
        355                 360                 365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu
    370                 375                 380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp
385                 390                 395                 400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp
                405                 410                 415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys
            420                 425                 430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys
        435                 440                 445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser
    450                 455                 460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn
465                 470                 475                 480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu
                485                 490                 495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val
            500                 505                 510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu
        515                 520                 525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly
    530                 535                 540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn
545                 550                 555                 560
Ala Glu Asn Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly
                565                 570                 575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala
            580                 585                 590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser
        595                 600                 605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu
    610                 615                 620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys
625                 630                 635                 640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile
                645                 650                 655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile
            660                 665                 670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser
        675                 680                 685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser
    690                 695                 700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp
705                 710                 715                 720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro
                725                 730                 735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro
            740                 745                 750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr
        755                 760                 765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn
    770                 775                 780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val
785                 790                 795                 800
Ala Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg
                805                 810                 815
Val Asn Ser Lys Glu Thr Glu Cys
            820

<210> 1748
<211> 824
<212> PRT
<213> Homo sapiens

<400> 1748
Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu
 1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu
            20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser
        35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr
    50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys
65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val
                85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln
            100                 105                 110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu
        115                 120                 125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly
    130                 135                 140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys
145                 150                 155                 160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser
                165                 170                 175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu
            180                 185                 190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu
        195                 200                 205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr
    210                 215                 220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly
225                 230                 235                 240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp
                245                 250                 255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe
            260                 265                 270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro
        275                 280                 285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr
    290                 295                 300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln
305                 310                 315                 320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His
                325                 330                 335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr
            340                 345                 350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala
        355                 360                 365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu
    370                 375                 380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp
385                 390                 395                 400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp
                405                 410                 415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys
            420                 425                 430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys
        435                 440                 445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser
    450                 455                 460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn
465                 470                 475                 480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu
                485                 490                 495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val
            500                 505                 510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu
        515                 520                 525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly
    530                 535                 540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn
545                 550                 555                 560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly
                565                 570                 575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala
            580                 585                 590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser
        595                 600                 605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu
    610                 615                 620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys
625                 630                 635                 640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile
                645                 650                 655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile
            660                 665                 670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser
        675                 680                 685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser
    690                 695                 700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp
705                 710                 715                 720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro
                725                 730                 735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro
            740                 745                 750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr
        755                 760                 765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn
    770                 775                 780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val
785                 790                 795                 800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg
                805                 810                 815
Val Asp Ser Lys Glu Thr Glu Cys
            820

<210> 1749
<211> 807
<212> PRT
<213> Homo sapiens

<400> 1749
Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu Glu
 1               5                  10                  15
Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser Asn
            20                  25                  30
Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr His
        35                  40                  45
Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys Leu
    50                  55                  60
Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val Val
65                  70                  75                  80
Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln Asp
                85                  90                  95
Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu Ala
            100                 105                 110
His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly Ala
        115                 120                 125
Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys Asp
    130                 135                 140
Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser Arg
145                 150                 155                 160
Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu Glu
                165                 170                 175
Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu Val
            180                 185                 190
His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr Cys
        195                 200                 205
Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly Arg
    210                 215                 220
Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp Arg
225                 230                 235                 240
Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe Lys
                245                 250                 255
Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro Gln
            260                 265                 270
Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr Pro
        275                 280                 285
Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln Phe
    290                 295                 300
Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His Leu
305                 310                 315                 320
Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr Val
                325                 330                 335
Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala Tyr
            340                 345                 350
Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu Thr
        355                 360                 365
Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp Leu
    370                 375                 380
Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp Pro
385                 390                 395                 400
Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys Tyr
                405                 410                 415
Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys Met
            420                 425                 430
Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser Lys
        435                 440                 445
Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn Ser
    450                 455                 460
Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu Asn
465                 470                 475                 480
Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val Gln
                485                 490                 495
Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu Thr
            500                 505                 510
Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly Val
        515                 520                 525
Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn Ala
    530                 535                 540
Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly Lys
545                 550                 555                 560
Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala Cys
                565                 570                 575
Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser Gly
            580                 585                 590
Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu Arg
        595                 600                 605
Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys Cys
    610                 615                 620
Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile Asp
625                 630                 635                 640
Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile Val
                645                 650                 655
Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser Ile
            660                 665                 670
Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser Leu
        675                 680                 685
Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp Ser
    690                 695                 700
Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro Gly
705                 710                 715                 720
Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro Lys
                725                 730                 735
Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr Asp
            740                 745                 750
Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn Ser
        755                 760                 765
Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val Thr
    770                 775                 780
Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg Val
785                 790                 795                 800
Asp Ser Lys Glu Thr Glu Cys
                805

<210> 1750
<211> 824
<212> PRT
<213> Homo sapiens

<400> 1750
Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu
 1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu
            20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser
        35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr
    50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys
65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val
                85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln
            100                 105                 110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu
        115                 120                 125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly
    130                 135                 140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys
145                 150                 155                 160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser
                165                 170                 175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu
            180                 185                 190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu
        195                 200                 205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr
    210                 215                 220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly
225                 230                 235                 240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp
                245                 250                 255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe
            260                 265                 270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro
        275                 280                 285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr
    290                 295                 300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln
305                 310                 315                 320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His
                325                 330                 335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr
            340                 345                 350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala
        355                 360                 365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu
    370                 375                 380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp
385                 390                 395                 400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp
                405                 410                 415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys
            420                 425                 430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys
        435                 440                 445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser
    450                 455                 460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn
465                 470                 475                 480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu
                485                 490                 495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val
            500                 505                 510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu
        515                 520                 525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly
    530                 535                 540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn
545                 550                 555                 560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly
                565                 570                 575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala
            580                 585                 590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser
        595                 600                 605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu
    610                 615                 620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys
625                 630                 635                 640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile
                645                 650                 655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile
            660                 665                 670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser
        675                 680                 685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser
    690                 695                 700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp
705                 710                 715                 720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro
                725                 730                 735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro
            740                 745                 750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr
        755                 760                 765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn
    770                 775                 780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val
785                 790                 795                 800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg
                805                 810                 815
Val Asp Ser Lys Glu Thr Glu Cys
            820

<210> 1751
<211> 807
<212> PRT
<213> Homo sapiens

<400> 1751
Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu Glu
 1               5                  10                  15
Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser Asn
            20                  25                  30
Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr His
        35                  40                  45
Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys Leu
    50                  55                  60
Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val Val
65                  70                  75                  80
Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln Asp
                85                  90                  95
Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu Ala
            100                 105                 110
His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly Ala
        115                 120                 125
Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys Asp
    130                 135                 140
Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser Arg
145                 150                 155                 160
Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu Glu
                165                 170                 175
Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu Val
            180                 185                 190
His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr Cys
        195                 200                 205
Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly Arg
    210                 215                 220
Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp Arg
225                 230                 235                 240
Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe Lys
                245                 250                 255
Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro Gln
            260                 265                 270
Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr Pro
        275                 280                 285
Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln Phe
    290                 295                 300
Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His Leu
305                 310                 315                 320
Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr Val
                325                 330                 335
Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala Tyr
            340                 345                 350
Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu Thr
        355                 360                 365
Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp Leu
    370                 375                 380
Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp Pro
385                 390                 395                 400
Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys Tyr
                405                 410                 415
Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys Met
            420                 425                 430
Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser Lys
        435                 440                 445
Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn Ser
    450                 455                 460
Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu Asn
465                 470                 475                 480
Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val Gln
                485                 490                 495
Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu Thr
            500                 505                 510
Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly Val
        515                 520                 525
Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn Ala
    530                 535                 540
Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly Lys
545                 550                 555                 560
Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala Cys
                565                 570                 575
Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser Gly
            580                 585                 590
Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu Arg
        595                 600                 605
Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys Cys
    610                 615                 620
Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile Asp
625                 630                 635                 640
Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile Val
                645                 650                 655
Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser Ile
            660                 665                 670
Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser Leu
        675                 680                 685
Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp Ser
    690                 695                 700
Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro Gly
705                 710                 715                 720
Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro Lys
                725                 730                 735
Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr Asp
            740                 745                 750
Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn Ser
        755                 760                 765
Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val Thr
    770                 775                 780
Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg Val
785                 790                 795                 800
Asp Ser Lys Glu Thr Glu Cys
                805

<210> 1752
<211> 824
<212> PRT
<213> Homo sapiens

<400> 1752
Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu
 1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu
            20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser
        35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr
    50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys
65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val
                85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Ala Lys Trp Gln
            100                 105                 110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu
        115                 120                 125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly
    130                 135                 140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys
145                 150                 155                 160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser
                165                 170                 175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu
            180                 185                 190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu
        195                 200                 205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr
    210                 215                 220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly
225                 230                 235                 240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp
                245                 250                 255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe
            260                 265                 270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro
        275                 280                 285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr
    290                 295                 300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln
305                 310                 315                 320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His
                325                 330                 335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr
            340                 345                 350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala
        355                 360                 365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu
    370                 375                 380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp
385                 390                 395                 400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp
                405                 410                 415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys
            420                 425                 430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys
        435                 440                 445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser
    450                 455                 460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn
465                 470                 475                 480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu
                485                 490                 495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val
            500                 505                 510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu
        515                 520                 525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly
    530                 535                 540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn
545                 550                 555                 560
Ala Glu Asn Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly
                565                 570                 575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala
            580                 585                 590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser
        595                 600                 605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu
    610                 615                 620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys
625                 630                 635                 640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile
                645                 650                 655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile
            660                 665                 670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser
        675                 680                 685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser
    690                 695                 700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp
705                 710                 715                 720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro
                725                 730                 735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro
            740                 745                 750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr
        755                 760                 765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn
    770                 775                 780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val
785                 790                 795                 800
Ala Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg
                805                 810                 815
Val Asn Ser Lys Glu Thr Glu Cys
            820

<210> 1753
<211> 824
<212> PRT
<213> Homo sapiens

<400> 1753
Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu
 1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu
            20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser
        35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr
    50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys
65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val
                85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln
            100                 105                 110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu
        115                 120                 125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly
    130                 135                 140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys
145                 150                 155                 160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser
                165                 170                 175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu
            180                 185                 190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu
        195                 200                 205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr
    210                 215                 220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly
225                 230                 235                 240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp
                245                 250                 255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe
            260                 265                 270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro
        275                 280                 285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr
    290                 295                 300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln
305                 310                 315                 320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His
                325                 330                 335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr
            340                 345                 350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala
        355                 360                 365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu
    370                 375                 380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp
385                 390                 395                 400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp
                405                 410                 415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys
            420                 425                 430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys
        435                 440                 445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser
    450                 455                 460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn
465                 470                 475                 480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu
                485                 490                 495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val
            500                 505                 510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu
        515                 520                 525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly
    530                 535                 540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn
545                 550                 555                 560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly
                565                 570                 575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala
            580                 585                 590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser
        595                 600                 605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu
    610                 615                 620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys
625                 630                 635                 640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile
                645                 650                 655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile
            660                 665                 670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser
        675                 680                 685
Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser
    690                 695                 700
Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp
705                 710                 715                 720
Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro
                725                 730                 735
Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro
            740                 745                 750
Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr
        755                 760                 765
Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn
    770                 775                 780
Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val
785                 790                 795                 800
Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg
                805                 810                 815
Val Asp Ser Lys Glu Thr Glu Cys
            820

<210> 1754
<211> 45
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(45)
<223> Xaa = Any Amino Acid

<400> 1754
Met Gly Leu Gln Ala Cys Ala Asn Ser Pro Leu Xaa Tyr Val Asp Ile
 1               5                  10                  15
Ala Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp
            20                  25                  30
Trp Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr
        35                  40                  45

<210> 1755
<211> 135
<212> PRT
<213> Homo sapiens

<400> 1755
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
 1               5                  10                  15
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu
            20                  25                  30
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        35                  40                  45
Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    50                  55                  60
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala
65                  70                  75                  80
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                85                  90                  95
Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala
            100                 105                 110
Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val
        115                 120                 125
Gly Ala Thr Thr Asp Trp Ser
    130                 135

<210> 1756
<211> 436
<212> PRT
<213> Homo sapiens

<400> 1756
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys
        435

<210> 1757
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1757
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Leu Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1758
<211> 436
<212> PRT
<213> Homo sapiens

<400> 1758
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys
        435

<210> 1759
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1759
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1760
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1760
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1761
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1761
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1762
<211> 575
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(575)
<223> Xaa = Any Amino Acid

<400> 1762
Glu Glu Leu Arg Val Arg Glu His Val Thr Gly Gly Ile Cys Gly Gly
 1               5                  10                  15
Ser Gln Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val
            20                  25                  30
Ala Val Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu
        35                  40                  45
Lys Ser Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile
    50                  55                  60
Leu Arg Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser
65                  70                  75                  80
Phe Asp Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly
                85                  90                  95
Cys Gln Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu
            100                 105                 110
Asn Val Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn
        115                 120                 125
Thr Ser Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala
    130                 135                 140
Gln Ile Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile
145                 150                 155                 160
Val Ile His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu
                165                 170                 175
Asp Gly Leu Ser Phe Thr Tyr Ser Leu Xaa Ile Trp Lys Asn Ser Ser
            180                 185                 190
Gly Val Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr
        195                 200                 205
Lys Leu Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu
    210                 215                 220
Leu Thr Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys
225                 230                 235                 240
Thr Thr Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser
                245                 250                 255
Val Gln Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn
            260                 265                 270
Met Thr Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro
        275                 280                 285
Gly Asn His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val
    290                 295                 300
Lys Thr Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile
305                 310                 315                 320
Tyr Leu Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp
                325                 330                 335
Ser Glu Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro
            340                 345                 350
Pro Val Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile
        355                 360                 365
Gly Ala Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro
    370                 375                 380
Leu Ile Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg
385                 390                 395                 400
Lys Ile Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro
                405                 410                 415
Leu Thr Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys
            420                 425                 430
Leu Asn Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys
        435                 440                 445
Pro Gly Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala
    450                 455                 460
Leu Phe Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg
465                 470                 475                 480
Cys Ile Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile
                485                 490                 495
Asp Glu Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr
            500                 505                 510
Ser Glu Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr
        515                 520                 525
Ile Ala Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys
    530                 535                 540
Tyr Ser Ser Gln Thr Ser Gln Asp Ser Gly Xaa Tyr Ser Asn Glu Asp
545                 550                 555                 560
Glu Ser Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
                565                 570                 575

<210> 1763
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1763
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1764
<211> 436
<212> PRT
<213> Homo sapiens

<400> 1764
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys
        435

<210> 1765
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1765
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1766
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1766
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1767
<211> 436
<212> PRT
<213> Homo sapiens

<400> 1767
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Leu Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Gln Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Leu Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys
        435

<210> 1768
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1768
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Phe Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1769
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1769
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Thr Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1770
<211> 434
<212> PRT
<213> Homo sapiens

<400> 1770
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Thr Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Asn Ile Ser Leu Asn
            420                 425                 430
Ser His


<210> 1771
<211> 496
<212> PRT
<213> Homo sapiens

<400> 1771
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Thr Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Ser Asp Ala
                405                 410                 415
Val Cys Glu Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser
            420                 425                 430
Thr Ser Glu Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser
        435                 440                 445
Thr Ile Ala Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys
    450                 455                 460
Lys Tyr Ser Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu
465                 470                 475                 480
Asp Glu Ser Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
                485                 490                 495

<210> 1772
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1772
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1773
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1773
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val
 1               5                  10                  15
Gly Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser
            20                  25                  30
Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg
        35                  40                  45
Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp
    50                  55                  60
Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln
65                  70                  75                  80
Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val
                85                  90                  95
Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser
            100                 105                 110
Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile
        115                 120                 125
Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile
    130                 135                 140
His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly
145                 150                 155                 160
Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp Lys Asn Ser Ser Gly Val
                165                 170                 175
Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu
            180                 185                 190
Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr
        195                 200                 205
Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr
    210                 215                 220
Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln
225                 230                 235                 240
Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr
                245                 250                 255
Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn
            260                 265                 270
His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr
        275                 280                 285
Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu
    290                 295                 300
Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu
305                 310                 315                 320
Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val
                325                 330                 335
Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala
            340                 345                 350
Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile
        355                 360                 365
Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile
    370                 375                 380
Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr
385                 390                 395                 400
Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn
                405                 410                 415
Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly
            420                 425                 430
Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe
        435                 440                 445
Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile
    450                 455                 460
Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu
465                 470                 475                 480
Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu
                485                 490                 495
Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala
            500                 505                 510
Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser
        515                 520                 525
Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser
    530                 535                 540
Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val
545                 550                 555

<210> 1774
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1774
Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn Ser Asp Glu Pro
 1               5                  10                  15
Lys


<210> 1775
<211> 781
<212> PRT
<213> Homo sapiens

<400> 1775
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
 1               5                  10                  15
Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
            20                  25                  30
Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
        35                  40                  45
Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
    50                  55                  60
Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
65                  70                  75                  80
Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                85                  90                  95
Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
            100                 105                 110
Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
        115                 120                 125
Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
    130                 135                 140
Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
145                 150                 155                 160
Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                165                 170                 175
Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
            180                 185                 190
Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
        195                 200                 205
Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
    210                 215                 220
Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
225                 230                 235                 240
Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                245                 250                 255
Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
            260                 265                 270
Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
        275                 280                 285
Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
    290                 295                 300
Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
305                 310                 315                 320
Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                325                 330                 335
Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
            340                 345                 350
Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
        355                 360                 365
His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
    370                 375                 380
Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
385                 390                 395                 400
Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                405                 410                 415
Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
            420                 425                 430
Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
        435                 440                 445
Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
    450                 455                 460
Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
465                 470                 475                 480
Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                485                 490                 495
Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
            500                 505                 510
Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
        515                 520                 525
Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
    530                 535                 540
Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
545                 550                 555                 560
Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                565                 570                 575
Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
            580                 585                 590
Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
        595                 600                 605
Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
    610                 615                 620
Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
625                 630                 635                 640
Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                645                 650                 655
Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
            660                 665                 670
Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
        675                 680                 685
Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
    690                 695                 700
Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
705                 710                 715                 720
Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                725                 730                 735
His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
            740                 745                 750
Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
        755                 760                 765
Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
    770                 775                 780

<210> 1776
<211> 781
<212> PRT
<213> Homo sapiens

<400> 1776
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
 1               5                  10                  15
Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
            20                  25                  30
Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
        35                  40                  45
Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
    50                  55                  60
Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
65                  70                  75                  80
Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                85                  90                  95
Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
            100                 105                 110
Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
        115                 120                 125
Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
    130                 135                 140
Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
145                 150                 155                 160
Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                165                 170                 175
Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
            180                 185                 190
Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
        195                 200                 205
Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
    210                 215                 220
Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
225                 230                 235                 240
Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                245                 250                 255
Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
            260                 265                 270
Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
        275                 280                 285
Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
    290                 295                 300
Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
305                 310                 315                 320
Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                325                 330                 335
Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
            340                 345                 350
Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
        355                 360                 365
His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
    370                 375                 380
Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
385                 390                 395                 400
Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                405                 410                 415
Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
            420                 425                 430
Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
        435                 440                 445
Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
    450                 455                 460
Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
465                 470                 475                 480
Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                485                 490                 495
Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
            500                 505                 510
Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
        515                 520                 525
Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
    530                 535                 540
Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
545                 550                 555                 560
Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                565                 570                 575
Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
            580                 585                 590
Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
        595                 600                 605
Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
    610                 615                 620
Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
625                 630                 635                 640
Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                645                 650                 655
Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
            660                 665                 670
Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
        675                 680                 685
Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
    690                 695                 700
Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
705                 710                 715                 720
Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                725                 730                 735
His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
            740                 745                 750
Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
        755                 760                 765
Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
    770                 775                 780

<210> 1777
<211> 781
<212> PRT
<213> Homo sapiens

<400> 1777
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
 1               5                  10                  15
Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
            20                  25                  30
Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
        35                  40                  45
Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
    50                  55                  60
Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
65                  70                  75                  80
Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                85                  90                  95
Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
            100                 105                 110
Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
        115                 120                 125
Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
    130                 135                 140
Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
145                 150                 155                 160
Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                165                 170                 175
Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
            180                 185                 190
Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
        195                 200                 205
Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
    210                 215                 220
Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
225                 230                 235                 240
Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                245                 250                 255
Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
            260                 265                 270
Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
        275                 280                 285
Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
    290                 295                 300
Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
305                 310                 315                 320
Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                325                 330                 335
Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
            340                 345                 350
Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
        355                 360                 365
His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
    370                 375                 380
Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
385                 390                 395                 400
Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                405                 410                 415
Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
            420                 425                 430
Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
        435                 440                 445
Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
    450                 455                 460
Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
465                 470                 475                 480
Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                485                 490                 495
Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
            500                 505                 510
Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
        515                 520                 525
Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
    530                 535                 540
Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
545                 550                 555                 560
Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                565                 570                 575
Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
            580                 585                 590
Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
        595                 600                 605
Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
    610                 615                 620
Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
625                 630                 635                 640
Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                645                 650                 655
Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
            660                 665                 670
Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
        675                 680                 685
Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
    690                 695                 700
Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
705                 710                 715                 720
Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                725                 730                 735
His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
            740                 745                 750
Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
        755                 760                 765
Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
    770                 775                 780

<210> 1778
<211> 781
<212> PRT
<213> Homo sapiens

<400> 1778
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
 1               5                  10                  15
Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
            20                  25                  30
Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
        35                  40                  45
Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
    50                  55                  60
Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
65                  70                  75                  80
Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                85                  90                  95
Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
            100                 105                 110
Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
        115                 120                 125
Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
    130                 135                 140
Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
145                 150                 155                 160
Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                165                 170                 175
Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
            180                 185                 190
Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
        195                 200                 205
Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
    210                 215                 220
Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
225                 230                 235                 240
Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                245                 250                 255
Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
            260                 265                 270
Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
        275                 280                 285
Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
    290                 295                 300
Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
305                 310                 315                 320
Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                325                 330                 335
Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
            340                 345                 350
Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
        355                 360                 365
His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
    370                 375                 380
Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
385                 390                 395                 400
Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                405                 410                 415
Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
            420                 425                 430
Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
        435                 440                 445
Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
    450                 455                 460
Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
465                 470                 475                 480
Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                485                 490                 495
Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
            500                 505                 510
Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
        515                 520                 525
Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
    530                 535                 540
Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
545                 550                 555                 560
Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                565                 570                 575
Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
            580                 585                 590
Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
        595                 600                 605
Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
    610                 615                 620
Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
625                 630                 635                 640
Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                645                 650                 655
Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
            660                 665                 670
Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
        675                 680                 685
Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
    690                 695                 700
Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
705                 710                 715                 720
Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                725                 730                 735
His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
            740                 745                 750
Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
        755                 760                 765
Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
    770                 775                 780

<210> 1779
<211> 781
<212> PRT
<213> Homo sapiens

<400> 1779
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
 1               5                  10                  15
Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
            20                  25                  30
Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
        35                  40                  45
Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
    50                  55                  60
Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
65                  70                  75                  80
Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                85                  90                  95
Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
            100                 105                 110
Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
        115                 120                 125
Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
    130                 135                 140
Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
145                 150                 155                 160
Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                165                 170                 175
Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
            180                 185                 190
Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
        195                 200                 205
Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
    210                 215                 220
Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
225                 230                 235                 240
Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                245                 250                 255
Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
            260                 265                 270
Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
        275                 280                 285
Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
    290                 295                 300
Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
305                 310                 315                 320
Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                325                 330                 335
Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
            340                 345                 350
Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
        355                 360                 365
His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
    370                 375                 380
Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
385                 390                 395                 400
Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                405                 410                 415
Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
            420                 425                 430
Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
        435                 440                 445
Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
    450                 455                 460
Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
465                 470                 475                 480
Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                485                 490                 495
Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
            500                 505                 510
Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
        515                 520                 525
Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
    530                 535                 540
Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
545                 550                 555                 560
Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                565                 570                 575
Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
            580                 585                 590
Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
        595                 600                 605
Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
    610                 615                 620
Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
625                 630                 635                 640
Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                645                 650                 655
Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
            660                 665                 670
Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
        675                 680                 685
Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
    690                 695                 700
Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
705                 710                 715                 720
Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                725                 730                 735
His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
            740                 745                 750
Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
        755                 760                 765
Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
    770                 775                 780

<210> 1780
<211> 800
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(800)
<223> Xaa = Any Amino Acid

<400> 1780
Ser Ile Pro Tyr Asn Cys Phe Glu Asn Pro Ala Trp Thr Met Ala Thr
 1               5                  10                  15
Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro Asp Arg Lys
            20                  25                  30
Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp Ser Gly Ile
        35                  40                  45
His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly Lys Gly Asn
    50                  55                  60
Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr Glu Trp Glu
65                  70                  75                  80
Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala Asp Ile Asp
                85                  90                  95
Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala Ala Met Phe
            100                 105                 110
Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr Gln Phe Asp
        115                 120                 125
Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro Ser Gln Met
    130                 135                 140
Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp Asp Ala Glu
145                 150                 155                 160
Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu Asn Asp Glu
                165                 170                 175
Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His Gln Leu Ser
            180                 185                 190
Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro Gln Met Val
        195                 200                 205
Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val Glu Thr Ala
    210                 215                 220
Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His Arg Glu Gly
225                 230                 235                 240
Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu Val Lys Met
                245                 250                 255
Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile Thr Thr Leu
            260                 265                 270
His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala Val Arg Leu
        275                 280                 285
Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys Thr Asn Val
    290                 295                 300
Thr Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu Ala Tyr Gly
305                 310                 315                 320
Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly Pro Gln Ala
                325                 330                 335
Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu Leu Trp Thr
            340                 345                 350
Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser Asn Lys Pro
        355                 360                 365
Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu His Leu Thr
    370                 375                 380
Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr Leu Arg Asn
385                 390                 395                 400
Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly Leu Leu Gly
                405                 410                 415
Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val Val Thr Cys
            420                 425                 430
Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr Lys Asn Lys
        435                 440                 445
Met Met Val Cys Pro Lys Trp Gly Gly Tyr Lys Arg Leu Leu Arg Ala
    450                 455                 460
Xaa Leu Val Leu Arg Ala Gly Gly Gln Gly Lys Thr Ser Leu Glu Pro
465                 470                 475                 480
Ala Ile Cys Ala Leu Arg His Leu Asp Thr Ala Arg His Gln Glu Ala
                485                 490                 495
Glu Met Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val
            500                 505                 510
Val Lys Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr
        515                 520                 525
Val Gly Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro
    530                 535                 540
Leu Arg Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg
545                 550                 555                 560
Ala His Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln
                565                 570                 575
Gln Phe Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr
            580                 585                 590
Gly Ala Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile
        595                 600                 605
Arg Gly Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro
    610                 615                 620
Ile Glu Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala
625                 630                 635                 640
Gln Asp Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala
                645                 650                 655
Pro Leu Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr
            660                 665                 670
Ala Ala Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Asn
        675                 680                 685
Arg Lys Arg Phe Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu
    690                 695                 700
Pro Met Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Trp Cys
705                 710                 715                 720
Pro Gly Glu Asn Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg
                725                 730                 735
Ser Phe His Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro
            740                 745                 750
Met Met Glu His Glu Ile Gly Gly His His Pro Gly Ala Asp Tyr Pro
        755                 760                 765
Val Asp Gly Leu Pro Asp Met Gly His Ala Gln Asp Leu Met Asp Gly
    770                 775                 780
Leu Pro Pro Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
785                 790                 795                 800

<210> 1781
<211> 45
<212> PRT
<213> Homo sapiens

<400> 1781
Arg His Gln Glu Ala Glu Met Ala Gln Asn Ala Val Arg Leu His Tyr
 1               5                  10                  15
Gly Leu Pro Val Val Val Lys Leu Leu His Pro Pro Ser His Trp Pro
            20                  25                  30
Leu Ile Ala Thr Val Gly Leu Ile Arg Asn Leu Ala Leu
        35                  40                  45

<210> 1782
<211> 781
<212> PRT
<213> Homo sapiens

<400> 1782
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
 1               5                  10                  15
Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
            20                  25                  30
Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
        35                  40                  45
Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
    50                  55                  60
Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
65                  70                  75                  80
Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                85                  90                  95
Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
            100                 105                 110
Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
        115                 120                 125
Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
    130                 135                 140
Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
145                 150                 155                 160
Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                165                 170                 175
Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
            180                 185                 190
Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
        195                 200                 205
Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
    210                 215                 220
Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
225                 230                 235                 240
Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                245                 250                 255
Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
            260                 265                 270
Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
        275                 280                 285
Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
    290                 295                 300
Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
305                 310                 315                 320
Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                325                 330                 335
Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
            340                 345                 350
Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
        355                 360                 365
His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
    370                 375                 380
Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
385                 390                 395                 400
Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                405                 410                 415
Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
            420                 425                 430
Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
        435                 440                 445
Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
    450                 455                 460
Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
465                 470                 475                 480
Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                485                 490                 495
Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
            500                 505                 510
Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
        515                 520                 525
Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
    530                 535                 540
Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
545                 550                 555                 560
Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                565                 570                 575
Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
            580                 585                 590
Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
        595                 600                 605
Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
    610                 615                 620
Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
625                 630                 635                 640
Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                645                 650                 655
Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
            660                 665                 670
Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
        675                 680                 685
Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
    690                 695                 700
Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
705                 710                 715                 720
Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                725                 730                 735
His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
            740                 745                 750
Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
        755                 760                 765
Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
    770                 775                 780

<210> 1783
<211> 781
<212> PRT
<213> Homo sapiens

<400> 1783
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
 1               5                  10                  15
Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
            20                  25                  30
Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
        35                  40                  45
Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
    50                  55                  60
Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
65                  70                  75                  80
Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                85                  90                  95
Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
            100                 105                 110
Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
        115                 120                 125
Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
    130                 135                 140
Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
145                 150                 155                 160
Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                165                 170                 175
Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
            180                 185                 190
Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
        195                 200                 205
Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
    210                 215                 220
Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
225                 230                 235                 240
Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                245                 250                 255
Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
            260                 265                 270
Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
        275                 280                 285
Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
    290                 295                 300
Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
305                 310                 315                 320
Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                325                 330                 335
Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
            340                 345                 350
Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
        355                 360                 365
His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
    370                 375                 380
Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
385                 390                 395                 400
Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                405                 410                 415
Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
            420                 425                 430
Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
        435                 440                 445
Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
    450                 455                 460
Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
465                 470                 475                 480
Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                485                 490                 495
Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
            500                 505                 510
Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
        515                 520                 525
Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
    530                 535                 540
Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
545                 550                 555                 560
Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                565                 570                 575
Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
            580                 585                 590
Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
        595                 600                 605
Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
    610                 615                 620
Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
625                 630                 635                 640
Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                645                 650                 655
Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
            660                 665                 670
Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
        675                 680                 685
Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
    690                 695                 700
Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
705                 710                 715                 720
Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                725                 730                 735
His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
            740                 745                 750
Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
        755                 760                 765
Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
    770                 775                 780

<210> 1784
<211> 781
<212> PRT
<213> Homo sapiens

<400> 1784
Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro
 1               5                  10                  15
Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp
            20                  25                  30
Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly
        35                  40                  45
Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr
    50                  55                  60
Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala
65                  70                  75                  80
Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala
                85                  90                  95
Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr
            100                 105                 110
Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro
        115                 120                 125
Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp
    130                 135                 140
Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu
145                 150                 155                 160
Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His
                165                 170                 175
Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro
            180                 185                 190
Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val
        195                 200                 205
Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His
    210                 215                 220
Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu
225                 230                 235                 240
Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile
                245                 250                 255
Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala
            260                 265                 270
Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys
        275                 280                 285
Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu
    290                 295                 300
Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly
305                 310                 315                 320
Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu
                325                 330                 335
Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser
            340                 345                 350
Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu
        355                 360                 365
His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr
    370                 375                 380
Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly
385                 390                 395                 400
Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val
                405                 410                 415
Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr
            420                 425                 430
Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val
        435                 440                 445
Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala
    450                 455                 460
Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met
465                 470                 475                 480
Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys
                485                 490                 495
Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly
            500                 505                 510
Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg
        515                 520                 525
Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His
    530                 535                 540
Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe
545                 550                 555                 560
Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala
                565                 570                 575
Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly
            580                 585                 590
Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu
        595                 600                 605
Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp
    610                 615                 620
Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu
625                 630                 635                 640
Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala
                645                 650                 655
Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys
            660                 665                 670
Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met
        675                 680                 685
Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly
    690                 695                 700
Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His
705                 710                 715                 720
Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu
                725                 730                 735
His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly
            740                 745                 750
Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro
        755                 760                 765
Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu
    770                 775                 780

<210> 1785
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1785
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Val Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ser Lys Arg Ala
            20                  25                  30
Asp Gly Ala Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Ala Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Met Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Asp Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Val Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Ser Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Met Ala Cys
                165                 170                 175
His Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1786
<211> 241
<212> PRT
<213> Homo sapiens

<400> 1786
Met Ile Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu
 1               5                  10                  15
Pro Ile Val Thr Leu Val Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr
            20                  25                  30
Thr Leu Ser Thr Glu Gln Met Leu Ser Ser Glu Ala Val Ala Val Asp
        35                  40                  45
Phe Gly Asn Tyr His Leu Gly Val Met Ser Trp Ile Ile Pro Val Phe
    50                  55                  60
Val Gly Leu Ser Cys Phe Gly Ser Val Asn Gly Ser Leu Phe Thr Ser
65                  70                  75                  80
Ser Arg Leu Phe Phe Val Gly Ser Arg Glu Gly His Leu Pro Ser Ile
                85                  90                  95
Leu Ser Met Ile His Pro Gln Leu Leu Thr Pro Val Pro Ser Leu Val
            100                 105                 110
Phe Thr Cys Val Met Thr Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe
        115                 120                 125
Ser Val Ile Asn Phe Phe Ser Phe Phe Asn Trp Leu Cys Val Ala Leu
    130                 135                 140
Ala Ile Ile Gly Met Ile Trp Leu Arg His Arg Lys Pro Glu Leu Glu
145                 150                 155                 160
Arg Pro Ile Lys Val Asn Leu Ala Leu Pro Val Phe Phe Ile Leu Ala
                165                 170                 175
Cys Leu Phe Leu Ile Ala Val Ser Phe Trp Lys Thr Pro Val Glu Cys
            180                 185                 190
Gly Ile Gly Phe Thr Ile Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe
        195                 200                 205
Gly Val Trp Trp Lys Asn Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe
    210                 215                 220
Ser Thr Thr Val Leu Cys Gln Lys Leu Met Gln Val Val Pro Gln Glu
225                 230                 235                 240
Thr


<210> 1787
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1787
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala
            20                  25                  30
Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys
                165                 170                 175
Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Lys Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1788
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1788
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala
            20                  25                  30
Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys
                165                 170                 175
Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1789
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1789
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala
            20                  25                  30
Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys
                165                 170                 175
Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1790
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1790
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Val Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ser Lys Arg Ala
            20                  25                  30
Asp Gly Ala Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Ala Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Met Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Ala Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys
                165                 170                 175
Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1791
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1791
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala
            20                  25                  30
Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys
                165                 170                 175
Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1792
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1792
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala
            20                  25                  30
Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys
                165                 170                 175
Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1793
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1793
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ser Ala Pro Val Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Ile Met Ala Ala Lys Arg Ala
            20                  25                  30
Asp Gly Ala Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Gly
        35                  40                  45
Asn Ile Thr Leu Leu Lys Gly Val Ala Val Ile Val Val Ala Ile Met
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Asp Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys
                165                 170                 175
Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Phe Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Thr Pro Trp Ser Val Ala Ser Asp Phe Thr
    450                 455                 460
Ile Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys
465                 470                 475                 480
Asn Lys Pro Lys Trp Ala Pro Pro Gly His Leu Ser Pro Arg Pro Ser
                485                 490                 495
Cys Val Arg Ser Ser Cys Met Val Val Pro Gln
            500                 505

<210> 1794
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1794
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala
            20                  25                  30
Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys
                165                 170                 175
Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Lys Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1795
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1795
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala
            20                  25                  30
Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys
                165                 170                 175
Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1796
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1796
Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Val Ala
 1               5                  10                  15
Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ser Lys Arg Ala
            20                  25                  30
Asp Gly Ala Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg
        35                  40                  45
Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Ala Ile Ile
    50                  55                  60
Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly
65                  70                  75                  80
Ser Pro Gly Leu Ala Leu Val Met Trp Ala Ala Cys Gly Val Phe Ser
                85                  90                  95
Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys
            100                 105                 110
Ser Gly Gly Asp Tyr Ala Tyr Met Leu Asp Val Tyr Gly Ser Leu Pro
        115                 120                 125
Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Val Ile Arg Pro Ser Ser
    130                 135                 140
Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu
145                 150                 155                 160
Phe Pro Ser Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Met Ala Cys
                165                 170                 175
His Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala
            180                 185                 190
Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu
        195                 200                 205
Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val
    210                 215                 220
Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val
225                 230                 235                 240
Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly
                245                 250                 255
Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg
            260                 265                 270
Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val
        275                 280                 285
Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln
    290                 295                 300
Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu
305                 310                 315                 320
Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe
                325                 330                 335
Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val
            340                 345                 350
Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro
        355                 360                 365
Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr
    370                 375                 380
Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe
385                 390                 395                 400
Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile
                405                 410                 415
Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn
            420                 425                 430
Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala
        435                 440                 445
Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile
    450                 455                 460
Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn
465                 470                 475                 480
Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys
                485                 490                 495
Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr
            500                 505

<210> 1797
<211> 1462
<212> PRT
<213> Homo sapiens

<400> 1797
Met Gly Ala Gln Asp Arg Pro Gln Cys His Phe Asp Ile Glu Ile Asn
 1               5                  10                  15
Arg Glu Pro Val Gly Arg Ile Met Phe Gln Leu Phe Ser Asp Ile Cys
            20                  25                  30
Pro Lys Thr Cys Lys Asn Phe Leu Cys Leu Cys Ser Gly Glu Lys Gly
        35                  40                  45
Leu Gly Lys Thr Thr Gly Lys Lys Leu Cys Tyr Lys Gly Ser Thr Phe
    50                  55                  60
His Arg Val Val Lys Asn Phe Met Ile Gln Gly Gly Asp Phe Ser Glu
65                  70                  75                  80
Gly Asn Gly Lys Gly Gly Glu Ser Ile Tyr Gly Gly Tyr Phe Lys Asp
                85                  90                  95
Glu Asn Phe Ile Leu Lys His Asp Arg Ala Phe Leu Leu Ser Met Ala
            100                 105                 110
Asn Arg Gly Lys His Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Lys
        115                 120                 125
Pro Ala Pro His Leu Asp Gly Val His Val Val Phe Gly Leu Val Ile
    130                 135                 140
Ser Gly Phe Glu Val Ile Glu Gln Ile Glu Asn Leu Lys Thr Asp Ala
145                 150                 155                 160
Ala Ser Arg Pro Tyr Ala Asp Val Arg Val Ile Asp Cys Gly Val Leu
                165                 170                 175
Ala Thr Lys Ser Ile Lys Asp Val Phe Glu Lys Lys Arg Lys Lys Pro
            180                 185                 190
Thr His Ser Glu Gly Ser Asp Ser Ser Ser Asn Ser Ser Ser Ser Ser
        195                 200                 205
Glu Ser Ser Ser Glu Ser Glu Leu Glu His Glu Arg Ser Arg Arg Arg
    210                 215                 220
Lys His Lys Arg Arg Pro Lys Val Lys Arg Ser Lys Lys Arg Arg Lys
225                 230                 235                 240
Glu Ala Ser Ser Ser Glu Glu Pro Arg Asn Lys His Ala Met Asn Pro
                245                 250                 255
Lys Gly His Ser Glu Arg Ser Asp Thr Asn Glu Lys Arg Ser Val Asp
            260                 265                 270
Ser Ser Ala Lys Arg Glu Lys Pro Val Val Arg Pro Glu Glu Ile Pro
        275                 280                 285
Pro Val Pro Glu Asn Arg Phe Leu Leu Arg Arg Asp Met Pro Val Val
    290                 295                 300
Thr Ala Glu Pro Glu Pro Lys Ile Pro Asp Val Ala Pro Ile Val Ser
305                 310                 315                 320
Asp Gln Lys Pro Ser Val Ser Lys Ser Gly Arg Lys Ile Lys Gly Arg
                325                 330                 335
Gly Thr Ile Arg Tyr His Thr Pro Pro Arg Ser Arg Ser Cys Ser Glu
            340                 345                 350
Ser Asp Asp Asp Asp Ser Ser Glu Thr Pro Pro His Trp Lys Glu Glu
        355                 360                 365
Met Gln Arg Leu Arg Ala Tyr Arg Pro Pro Ser Gly Glu Lys Trp Ser
    370                 375                 380
Lys Gly Asp Lys Leu Ser Asp Pro Cys Ser Ser Arg Trp Asp Glu Arg
385                 390                 395                 400
Ser Leu Ser Gln Arg Ser Arg Ser Trp Ser Tyr Asn Gly Tyr Tyr Ser
                405                 410                 415
Asp Leu Ser Thr Ala Arg His Ser Gly His His Lys Lys Arg Arg Lys
            420                 425                 430
Glu Lys Lys Val Lys His Lys Lys Lys Gly Lys Lys Gln Lys His Cys
        435                 440                 445
Arg Arg His Lys Gln Thr Lys Lys Arg Arg Ile Leu Ile Pro Ser Asp
    450                 455                 460
Ile Glu Ser Ser Lys Ser Ser Thr Arg Arg Met Lys Ser Ser Cys Asp
465                 470                 475                 480
Arg Glu Arg Ser Ser Arg Ser Ser Ser Leu Ser Ser His His Ser Ser
                485                 490                 495
Lys Arg Asp Trp Ser Lys Ser Asp Lys Asp Val Gln Ser Ser Leu Thr
            500                 505                 510
His Ser Ser Arg Asp Ser Tyr Arg Ser Lys Ser His Ser Gln Ser Tyr
        515                 520                 525
Ser Arg Gly Ser Ser Arg Ser Arg Thr Ala Ser Lys Ser Ser Ser His
    530                 535                 540
Ser Arg Ser Arg Ser Lys Ser Arg Ser Ser Ser Lys Ser Gly His Arg
545                 550                 555                 560
Lys Arg Ala Ser Lys Ser Pro Arg Lys Thr Ala Ser Gln Leu Ser Glu
                565                 570                 575
Asn Lys Pro Val Lys Thr Glu Pro Leu Arg Ala Thr Met Ala Gln Asn
            580                 585                 590
Glu Asn Val Val Val Gln Pro Val Val Ala Glu Asn Ile Pro Val Ile
        595                 600                 605
Pro Leu Ser Asp Ser Pro Pro Pro Ser Arg Trp Lys Pro Gly Gln Lys
    610                 615                 620
Pro Trp Lys Pro Ser Tyr Glu Arg Ile Gln Glu Met Lys Ala Lys Thr
625                 630                 635                 640
Thr His Leu Leu Pro Ile Gln Ser Thr Tyr Ser Leu Ala Asn Ile Lys
                645                 650                 655
Glu Thr Gly Ser Ser Ser Ser Tyr His Lys Arg Glu Lys Asn Ser Glu
            660                 665                 670
Ser Asp Gln Ser Thr Tyr Ser Lys Tyr Ser Asp Arg Ser Ser Glu Ser
        675                 680                 685
Ser Pro Arg Ser Arg Ser Arg Ser Ser Arg Ser Arg Ser Tyr Ser Arg
    690                 695                 700
Ser Tyr Thr Arg Ser Arg Ser Leu Ala Ser Ser His Ser Arg Ser Arg
705                 710                 715                 720
Ser Pro Ser Ser Arg Ser His Ser Arg Asn Lys Tyr Ser Asp His Ser
                725                 730                 735
Gln Cys Ser Arg Ser Ser Ser Tyr Thr Ser Ile Ser Ser Asp Asp Gly
            740                 745                 750
Arg Arg Ala Lys Arg Arg Leu Arg Ser Ser Gly Lys Lys Asn Ser Val
        755                 760                 765
Ser His Lys Lys His Ser Ser Ser Ser Glu Lys Thr Leu His Ser Lys
    770                 775                 780
Tyr Val Lys Gly Arg Asp Arg Ser Ser Cys Val Arg Lys Tyr Ser Glu
785                 790                 795                 800
Ser Arg Ser Ser Leu Asp Tyr Ser Ser Asp Ser Glu Gln Ser Ser Val
                805                 810                 815
Gln Ala Thr Gln Ser Ala Gln Glu Lys Glu Lys Gln Gly Gln Met Glu
            820                 825                 830
Arg Thr His Asn Lys Gln Glu Lys Asn Arg Gly Glu Glu Lys Ser Lys
        835                 840                 845
Ser Glu Arg Glu Cys Pro His Ser Lys Lys Arg Thr Leu Lys Glu Asn
    850                 855                 860
Leu Ser Asp His Leu Arg Asn Gly Ser Lys Pro Lys Arg Lys Asn Tyr
865                 870                 875                 880
Ala Gly Ser Lys Trp Asp Ser Glu Ser Asn Ser Glu Arg Asp Val Thr
                885                 890                 895
Lys Asn Ser Lys Asn Asp Ser His Pro Ser Ser Asp Lys Glu Glu Gly
            900                 905                 910
Glu Ala Thr Ser Asp Ser Glu Ser Glu Val Ser Glu Ile His Ile Lys
        915                 920                 925
Val Lys Pro Thr Thr Lys Ser Ser Thr Asn Thr Ser Leu Pro Asp Asp
    930                 935                 940
Asn Gly Ala Trp Lys Ser Ser Lys Gln Arg Thr Ser Thr Ser Asp Ser
945                 950                 955                 960
Glu Gly Ser Cys Ser Asn Ser Glu Asn Asn Arg Gly Lys Pro Gln Lys
                965                 970                 975
His Lys His Gly Ser Lys Glu Asn Leu Lys Arg Glu His Thr Lys Lys
            980                 985                 990
Val Lys Glu Lys Leu Lys Gly Lys Lys Asp Lys Lys His Lys Ala Pro
        995                 1000                1005
Lys Arg Lys Gln Ala Phe His Trp Gln Pro Pro Leu Glu Phe Gly Glu
    1010                1015                1020
Glu Glu Glu Glu Glu Ile Asp Asp Lys Gln Val Thr Gln Glu Ser Lys
1025                1030                1035                1040
Glu Lys Lys Val Ser Glu Asn Asn Glu Thr Ile Lys Asp Asn Ile Leu
                1045                1050                1055
Lys Thr Glu Lys Ser Ser Glu Glu Asp Leu Ser Gly Lys His Asp Thr
            1060                1065                1070
Val Thr Val Ser Ser Asp Leu Asp Gln Phe Thr Lys Asp Asp Ser Lys
        1075                1080                1085
Leu Ser Ile Ser Pro Thr Ala Leu Asn Thr Glu Glu Asn Val Ala Cys
    1090                1095                1100
Leu Gln Asn Ile Gln His Val Glu Glu Ser Val Pro Asn Gly Val Glu
1105                1110                1115                1120
Asp Val Leu Gln Thr Asp Asp Asn Met Glu Ile Cys Thr Pro Asp Arg
                1125                1130                1135
Ser Ser Pro Ala Lys Val Glu Glu Thr Ser Pro Leu Gly Asn Ala Arg
            1140                1145                1150
Leu Asp Thr Pro Asp Ile Asn Ile Val Leu Lys Gln Asp Met Ala Thr
        1155                1160                1165
Glu His Pro Gln Ala Glu Val Val Lys Gln Glu Ser Ser Met Ser Glu
    1170                1175                1180
Ser Lys Val Leu Gly Glu Val Gly Lys Gln Asp Ser Ser Ser Ala Ser
1185                1190                1195                1200
Leu Ala Ser Ala Gly Glu Ser Thr Gly Lys Lys Glu Val Ala Glu Lys
                1205                1210                1215
Ser Gln Ile Asn Leu Ile Asp Lys Lys Trp Lys Pro Leu Gln Gly Val
            1220                1225                1230
Gly Asn Leu Ala Ala Pro Asn Ala Ala Thr Ser Ser Ala Val Glu Val
        1235                1240                1245
Lys Val Leu Thr Thr Val Pro Glu Met Lys Pro Gln Gly Leu Arg Ile
    1250                1255                1260
Glu Ile Lys Ser Lys Asn Lys Val Arg Pro Gly Ser Leu Phe Asp Glu
1265                1270                1275                1280
Val Arg Lys Thr Ala Arg Leu Asn Arg Arg Pro Arg Asn Gln Glu Ser
                1285                1290                1295
Ser Ser Asp Glu Gln Thr Pro Ser Arg Asp Asp Asp Ser Gln Ser Arg
            1300                1305                1310
Ser Pro Ser Arg Ser Arg Ser Lys Ser Glu Thr Lys Ser Arg His Arg
        1315                1320                1325
Thr Arg Ser Val Ser Tyr Ser His Ser Arg Ser Arg Ser Arg Ser Ser
    1330                1335                1340
Thr Ser Ser Tyr Arg Ser Arg Ser Tyr Ser Arg Ser Arg Ser Arg Gly
1345                1350                1355                1360
Trp Tyr Ser Arg Gly Arg Thr Arg Ser Arg Ser Ser Ser Tyr Arg Ser
                1365                1370                1375
Tyr Lys Ser His Arg Thr Ser Ser Arg Ser Arg Ser Arg Ser Ser Ser
            1380                1385                1390
Tyr Asp Pro His Ser Arg Ser Arg Ser Tyr Thr Tyr Asp Ser Tyr Tyr
        1395                1400                1405
Ser Arg Ser Arg Ser Arg Ser Arg Ser Gln Arg Ser Asp Ser Tyr His
    1410                1415                1420
Arg Gly Arg Ser Tyr Asn Arg Arg Ser Arg Ser Cys Arg Ser Tyr Gly
1425                1430                1435                1440
Ser Asp Ser Glu Ser Asp Arg Ser Tyr Ser His His Arg Ser Pro Ser
                1445                1450                1455
Glu Ser Ser Arg Tyr Ser
            1460

<210> 1798
<211> 1462
<212> PRT
<213> Homo sapiens

<400> 1798
Met Gly Ala Gln Asp Arg Pro Gln Cys His Phe Asp Ile Glu Ile Asn
 1               5                  10                  15
Arg Glu Pro Val Gly Arg Ile Met Phe Gln Leu Phe Ser Asp Ile Cys
            20                  25                  30
Pro Lys Thr Cys Lys Asn Phe Leu Cys Leu Cys Ser Gly Glu Lys Gly
        35                  40                  45
Leu Gly Lys Thr Thr Gly Lys Lys Leu Cys Tyr Lys Gly Ser Thr Phe
    50                  55                  60
His Arg Val Val Lys Asn Phe Met Ile Gln Gly Gly Asp Phe Ser Glu
65                  70                  75                  80
Gly Asn Gly Lys Gly Gly Glu Ser Ile Tyr Gly Gly Tyr Phe Lys Asp
                85                  90                  95
Glu Asn Phe Ile Leu Lys His Asp Arg Ala Phe Leu Leu Ser Met Ala
            100                 105                 110
Asn Arg Gly Lys His Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Lys
        115                 120                 125
Pro Ala Pro His Leu Asp Gly Val His Val Val Phe Gly Leu Val Ile
    130                 135                 140
Ser Gly Phe Glu Val Ile Glu Gln Ile Glu Asn Leu Lys Thr Asp Ala
145                 150                 155                 160
Ala Ser Arg Pro Tyr Ala Asp Val Arg Val Ile Asp Cys Gly Val Leu
                165                 170                 175
Ala Thr Lys Ser Ile Lys Asp Val Phe Glu Lys Lys Arg Lys Lys Pro
            180                 185                 190
Thr His Ser Glu Gly Ser Asp Ser Ser Ser Asn Ser Ser Ser Ser Ser
        195                 200                 205
Glu Ser Ser Ser Glu Ser Glu Leu Glu His Glu Arg Ser Arg Arg Arg
    210                 215                 220
Lys His Lys Arg Arg Pro Lys Val Lys Arg Ser Lys Lys Arg Arg Lys
225                 230                 235                 240
Glu Ala Ser Ser Ser Glu Glu Pro Arg Asn Lys His Ala Met Asn Pro
                245                 250                 255
Lys Gly His Ser Glu Arg Ser Asp Thr Asn Glu Lys Arg Ser Val Asp
            260                 265                 270
Ser Ser Ala Lys Arg Glu Lys Pro Val Val Arg Pro Glu Glu Ile Pro
        275                 280                 285
Pro Val Pro Glu Asn Arg Phe Leu Leu Arg Arg Asp Met Pro Val Val
    290                 295                 300
Thr Ala Glu Pro Glu Pro Lys Ile Pro Asp Val Ala Pro Ile Val Ser
305                 310                 315                 320
Asp Gln Lys Pro Ser Val Ser Lys Ser Gly Arg Lys Ile Lys Gly Arg
                325                 330                 335
Gly Thr Ile Arg Tyr His Thr Pro Pro Arg Ser Arg Ser Cys Ser Glu
            340                 345                 350
Ser Asp Asp Asp Asp Ser Ser Glu Thr Pro Pro His Trp Lys Glu Glu
        355                 360                 365
Met Gln Arg Leu Arg Ala Tyr Arg Pro Pro Ser Gly Glu Lys Trp Ser
    370                 375                 380
Lys Gly Asp Lys Leu Ser Asp Pro Cys Ser Ser Arg Trp Asp Glu Arg
385                 390                 395                 400
Ser Leu Ser Gln Arg Ser Arg Ser Trp Ser Tyr Asn Gly Tyr Tyr Ser
                405                 410                 415
Asp Leu Ser Thr Ala Arg His Ser Gly His His Lys Lys Arg Arg Lys
            420                 425                 430
Glu Lys Lys Val Lys His Lys Lys Lys Gly Lys Lys Gln Lys His Cys
        435                 440                 445
Arg Arg His Lys Gln Thr Lys Lys Arg Arg Ile Leu Ile Pro Ser Asp
    450                 455                 460
Ile Glu Ser Ser Lys Ser Ser Thr Arg Arg Met Lys Ser Ser Cys Asp
465                 470                 475                 480
Arg Glu Arg Ser Ser Arg Ser Ser Ser Leu Ser Ser His His Ser Ser
                485                 490                 495
Lys Arg Asp Trp Ser Lys Ser Asp Lys Asp Val Gln Ser Ser Leu Thr
            500                 505                 510
His Ser Ser Arg Asp Ser Tyr Arg Ser Lys Ser His Ser Gln Ser Tyr
        515                 520                 525
Ser Arg Gly Ser Ser Arg Ser Arg Thr Ala Ser Lys Ser Ser Ser His
    530                 535                 540
Ser Arg Ser Arg Ser Lys Ser Arg Ser Ser Ser Lys Ser Gly His Arg
545                 550                 555                 560
Lys Arg Ala Ser Lys Ser Pro Arg Lys Thr Ala Ser Gln Leu Ser Glu
                565                 570                 575
Asn Lys Pro Val Lys Thr Glu Pro Leu Arg Ala Thr Met Ala Gln Asn
            580                 585                 590
Glu Asn Val Val Val Gln Pro Val Val Ala Glu Asn Ile Pro Val Ile
        595                 600                 605
Pro Leu Ser Asp Ser Pro Pro Pro Ser Arg Trp Lys Pro Gly Gln Lys
    610                 615                 620
Pro Trp Lys Pro Ser Tyr Glu Arg Ile Gln Glu Met Lys Ala Lys Thr
625                 630                 635                 640
Thr His Leu Leu Pro Ile Gln Ser Thr Tyr Ser Leu Ala Asn Ile Lys
                645                 650                 655
Glu Thr Gly Ser Ser Ser Ser Tyr His Lys Arg Glu Lys Asn Ser Glu
            660                 665                 670
Ser Asp Gln Ser Thr Tyr Ser Lys Tyr Ser Asp Arg Ser Ser Glu Ser
        675                 680                 685
Ser Pro Arg Ser Arg Ser Arg Ser Ser Arg Ser Arg Ser Tyr Ser Arg
    690                 695                 700
Ser Tyr Thr Arg Ser Arg Ser Leu Ala Ser Ser His Ser Arg Ser Arg
705                 710                 715                 720
Ser Pro Ser Ser Arg Ser His Ser Arg Asn Lys Tyr Ser Asp His Ser
                725                 730                 735
Gln Cys Ser Arg Ser Ser Ser Tyr Thr Ser Ile Ser Ser Asp Asp Gly
            740                 745                 750
Arg Arg Ala Lys Arg Arg Leu Arg Ser Ser Gly Lys Lys Asn Ser Val
        755                 760                 765
Ser His Lys Lys His Ser Ser Ser Ser Glu Lys Thr Leu His Ser Lys
    770                 775                 780
Tyr Val Lys Gly Arg Asp Arg Ser Ser Cys Val Arg Lys Tyr Ser Glu
785                 790                 795                 800
Ser Arg Ser Ser Leu Asp Tyr Ser Ser Asp Ser Glu Gln Ser Ser Val
                805                 810                 815
Gln Ala Thr Gln Ser Ala Gln Glu Lys Glu Lys Gln Gly Gln Met Glu
            820                 825                 830
Arg Thr His Asn Lys Gln Glu Lys Asn Arg Gly Glu Glu Lys Ser Lys
        835                 840                 845
Ser Glu Arg Glu Cys Pro His Ser Lys Lys Arg Thr Leu Lys Glu Asn
    850                 855                 860
Leu Ser Asp His Leu Arg Asn Gly Ser Lys Pro Lys Arg Lys Asn Tyr
865                 870                 875                 880
Ala Gly Ser Lys Trp Asp Ser Glu Ser Asn Ser Glu Arg Asp Val Thr
                885                 890                 895
Lys Asn Ser Lys Asn Asp Ser His Pro Ser Ser Asp Lys Glu Glu Gly
            900                 905                 910
Glu Ala Thr Ser Asp Ser Glu Ser Glu Val Ser Glu Ile His Ile Lys
        915                 920                 925
Val Lys Pro Thr Thr Lys Ser Ser Thr Asn Thr Ser Leu Pro Asp Asp
    930                 935                 940
Asn Gly Ala Trp Lys Ser Ser Lys Gln Arg Thr Ser Thr Ser Asp Ser
945                 950                 955                 960
Glu Gly Ser Cys Ser Asn Ser Glu Asn Asn Arg Gly Lys Pro Gln Lys
                965                 970                 975
His Lys His Gly Ser Lys Glu Asn Leu Lys Arg Glu His Thr Lys Lys
            980                 985                 990
Val Lys Glu Lys Leu Lys Gly Lys Lys Asp Lys Lys His Lys Ala Pro
        995                 1000                1005
Lys Arg Lys Gln Ala Phe His Trp Gln Pro Pro Leu Glu Phe Gly Glu
    1010                1015                1020
Glu Glu Glu Glu Glu Ile Asp Asp Lys Gln Val Thr Gln Glu Ser Lys
1025                1030                1035                1040
Glu Lys Lys Val Ser Glu Asn Asn Glu Thr Ile Lys Asp Asn Ile Leu
                1045                1050                1055
Lys Thr Glu Lys Ser Ser Glu Glu Asp Leu Ser Gly Lys His Asp Thr
            1060                1065                1070
Val Thr Val Ser Ser Asp Leu Asp Gln Phe Thr Lys Asp Asp Ser Lys
        1075                1080                1085
Leu Ser Ile Ser Pro Thr Ala Leu Asn Thr Glu Glu Asn Val Ala Cys
    1090                1095                1100
Leu Gln Asn Ile Gln His Val Glu Glu Ser Val Pro Asn Gly Val Glu
1105                1110                1115                1120
Asp Val Leu Gln Thr Asp Asp Asn Met Glu Ile Cys Thr Pro Asp Arg
                1125                1130                1135
Ser Ser Pro Ala Lys Val Glu Glu Thr Ser Pro Leu Gly Asn Ala Arg
            1140                1145                1150
Leu Asp Thr Pro Asp Ile Asn Ile Val Leu Lys Gln Asp Met Ala Thr
        1155                1160                1165
Glu His Pro Gln Ala Glu Val Val Lys Gln Glu Ser Ser Met Ser Glu
    1170                1175                1180
Ser Lys Val Leu Gly Glu Val Gly Lys Gln Asp Ser Ser Ser Ala Ser
1185                1190                1195                1200
Leu Ala Ser Ala Gly Glu Ser Thr Gly Lys Lys Glu Val Ala Glu Lys
                1205                1210                1215
Ser Gln Ile Asn Leu Ile Asp Lys Lys Trp Lys Pro Leu Gln Gly Val
            1220                1225                1230
Gly Asn Leu Ala Ala Pro Asn Ala Ala Thr Ser Ser Ala Val Glu Val
        1235                1240                1245
Lys Val Leu Thr Thr Val Pro Glu Met Lys Pro Gln Gly Leu Arg Ile
    1250                1255                1260
Glu Ile Lys Ser Lys Asn Lys Val Arg Pro Gly Ser Leu Phe Asp Glu
1265                1270                1275                1280
Val Arg Lys Thr Ala Arg Leu Asn Arg Arg Pro Arg Asn Gln Glu Ser
                1285                1290                1295
Ser Ser Asp Glu Gln Thr Pro Ser Arg Asp Asp Asp Ser Gln Ser Arg
            1300                1305                1310
Ser Pro Ser Arg Ser Arg Ser Lys Ser Glu Thr Lys Ser Arg His Arg
        1315                1320                1325
Thr Arg Ser Val Ser Tyr Ser His Ser Arg Ser Arg Ser Arg Ser Ser
    1330                1335                1340
Thr Ser Ser Tyr Arg Ser Arg Ser Tyr Ser Arg Ser Arg Ser Arg Gly
1345                1350                1355                1360
Trp Tyr Ser Arg Gly Arg Thr Arg Ser Arg Ser Ser Ser Tyr Arg Ser
                1365                1370                1375
Tyr Lys Ser His Arg Thr Ser Ser Arg Ser Arg Ser Arg Ser Ser Ser
            1380                1385                1390
Tyr Asp Pro His Ser Arg Ser Arg Ser Tyr Thr Tyr Asp Ser Tyr Tyr
        1395                1400                1405
Ser Arg Ser Arg Ser Arg Ser Arg Ser Gln Arg Ser Asp Ser Tyr His
    1410                1415                1420
Arg Gly Arg Ser Tyr Asn Arg Arg Ser Arg Ser Cys Arg Ser Tyr Gly
1425                1430                1435                1440
Ser Asp Ser Glu Ser Asp Arg Ser Tyr Ser His His Arg Ser Pro Ser
                1445                1450                1455
Glu Ser Ser Arg Tyr Ser
            1460

<210> 1799
<211> 1023
<212> PRT
<213> Homo sapiens

<400> 1799
Arg Arg Arg Arg Ser Val Ser Gly Val Gly Val Trp Leu Gln Trp Gln
 1               5                  10                  15
Cys Phe Leu Phe Cys Ser Arg Gly Pro Ala Gln Ala Gly Gly Gln Pro
            20                  25                  30
Ala Leu Ala Ala Thr Ser Val Ala Met Gly Ala Gln Asp Arg Pro Gln
        35                  40                  45
Cys His Phe Asp Ile Glu Ile Asn Arg Glu Pro Val Gly Arg Ile Met
    50                  55                  60
Phe Gln Leu Phe Ser Asp Ile Cys Pro Lys Thr Cys Lys Asn Phe Leu
65                  70                  75                  80
Cys Leu Cys Ser Gly Glu Lys Gly Leu Gly Lys Thr Thr Gly Lys Lys
                85                  90                  95
Leu Cys Tyr Lys Gly Ser Thr Phe His Arg Val Val Lys Asn Phe Met
            100                 105                 110
Ile Gln Gly Gly Asp Phe Ser Glu Gly Asn Gly Lys Gly Gly Glu Ser
        115                 120                 125
Ile Tyr Gly Gly Tyr Phe Lys Asp Glu Asn Phe Ile Leu Lys His Asp
    130                 135                 140
Arg Ala Phe Leu Leu Ser Met Ala Asn Arg Gly Lys His Thr Asn Gly
145                 150                 155                 160
Ser Gln Phe Phe Ile Thr Thr Lys Pro Ala Pro His Leu Asp Gly Val
                165                 170                 175
His Val Val Phe Gly Leu Val Ile Ser Gly Phe Glu Val Ile Glu Gln
            180                 185                 190
Ile Glu Asn Leu Lys Thr Asp Ala Ala Ser Arg Pro Tyr Ala Asp Val
        195                 200                 205
Arg Val Ile Asp Cys Gly Val Leu Ala Thr Lys Ser Ile Lys Asp Val
    210                 215                 220
Phe Glu Lys Lys Arg Lys Lys Pro Thr His Ser Glu Gly Ser Asp Ser
225                 230                 235                 240
Ser Ser Asn Ser Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser Glu Leu
                245                 250                 255
Glu His Glu Arg Ser Arg Arg Arg Lys His Lys Arg Arg Pro Lys Val
            260                 265                 270
Lys Arg Ser Lys Lys Arg Arg Lys Glu Ala Ser Ser Ser Glu Glu Pro
        275                 280                 285
Arg Asn Lys His Ala Met Asn Pro Lys Gly His Ser Glu Arg Ser Asp
    290                 295                 300
Thr Asn Glu Lys Arg Ser Val Asp Ser Ser Ala Lys Arg Glu Lys Pro
305                 310                 315                 320
Val Val Arg Pro Glu Glu Ile Pro Pro Val Pro Glu Asn Arg Phe Leu
                325                 330                 335
Leu Arg Arg Asp Met Pro Val Val Thr Ala Glu Pro Glu Pro Lys Ile
            340                 345                 350
Pro Asp Val Ala Pro Ile Val Ser Asp Gln Lys Pro Ser Val Ser Lys
        355                 360                 365
Ser Gly Arg Lys Ile Lys Gly Arg Gly Thr Ile Arg Tyr His Thr Pro
    370                 375                 380
Pro Arg Ser Arg Ser Cys Ser Glu Ser Asp Asp Asp Asp Ser Ser Glu
385                 390                 395                 400
Thr Pro Pro His Trp Lys Glu Glu Met Gln Arg Leu Arg Ala Tyr Arg
                405                 410                 415
Pro Pro Ser Gly Glu Lys Trp Ser Lys Gly Asp Lys Leu Ser Asp Pro
            420                 425                 430
Cys Ser Ser Arg Trp Asp Glu Arg Ser Leu Ser Gln Arg Ser Arg Ser
        435                 440                 445
Trp Ser Tyr Asn Gly Tyr Tyr Ser Asp Leu Ser Thr Ala Arg His Ser
    450                 455                 460
Gly His His Lys Lys Arg Arg Lys Glu Lys Lys Val Lys His Lys Lys
465                 470                 475                 480
Lys Gly Lys Lys Gln Lys His Cys Arg Arg His Lys Gln Thr Lys Lys
                485                 490                 495
Arg Arg Ile Leu Ile Pro Ser Asp Ile Glu Ser Ser Lys Ser Ser Thr
            500                 505                 510
Arg Arg Met Lys Ser Ser Cys Asp Arg Glu Arg Ser Ser Arg Ser Ser
        515                 520                 525
Ser Leu Ser Ser His His Ser Ser Lys Arg Asp Trp Ser Lys Ser Asp
    530                 535                 540
Lys Asp Val Gln Ser Ser Leu Thr His Ser Ser Arg Asp Ser Tyr Arg
545                 550                 555                 560
Ser Lys Ser His Ser Gln Ser Tyr Ser Arg Gly Ser Ser Arg Ser Arg
                565                 570                 575
Thr Ala Ser Lys Ser Ser Ser His Ser Arg Ser Arg Ser Lys Ser Arg
            580                 585                 590
Ser Ser Ser Lys Ser Gly His Arg Lys Arg Ala Ser Lys Ser Pro Arg
        595                 600                 605
Lys Thr Ala Ser Gln Leu Ser Glu Asn Lys Pro Val Lys Thr Glu Pro
    610                 615                 620
Leu Arg Ala Thr Met Ala Gln Asn Glu Asn Val Val Val Gln Pro Val
625                 630                 635                 640
Val Ala Glu Asn Ile Pro Val Ile Pro Leu Ser Asp Ser Pro Pro Pro
                645                 650                 655
Ser Arg Trp Lys Pro Gly Glu Lys Pro Trp Lys Pro Ser Tyr Glu Arg
            660                 665                 670
Ile Gln Glu Met Lys Ala Lys Thr Thr His Leu Leu Pro Ile Gln Ser
        675                 680                 685
Thr Tyr Ser Leu Ala Asn Ile Lys Glu Thr Gly Ser Ser Ser Ser Tyr
    690                 695                 700
His Lys Arg Glu Lys Asn Ser Glu Ser Asp Gln Ser Thr Tyr Ser Lys
705                 710                 715                 720
Tyr Ser Asp Arg Ser Ser Glu Ser Ser Pro Arg Ser Arg Ser Arg Ser
                725                 730                 735
Ser Arg Ser Arg Ser Tyr Ser Arg Ser Tyr Thr Arg Ser Arg Ser Leu
            740                 745                 750
Ala Ser Ser His Ser Arg Ser Arg Ser Pro Ser Ser Arg Ser His Ser
        755                 760                 765
Arg Asn Lys Tyr Ser Asp His Ser Gln Cys Ser Arg Ser Ser Ser Tyr
    770                 775                 780
Thr Ser Ile Ser Ser Asp Asp Gly Arg Arg Ala Lys Arg Arg Leu Arg
785                 790                 795                 800
Ser Ser Gly Lys Lys Asn Ser Val Ser His Lys Lys His Ser Ser Ser
                805                 810                 815
Ser Glu Lys Thr Leu His Ser Lys Tyr Val Lys Gly Arg Asp Arg Ser
            820                 825                 830
Ser Cys Val Arg Lys Tyr Ser Glu Ser Arg Ser Ser Leu Asp Tyr Leu
        835                 840                 845
Ser Asp Ser Glu Gln Ser Gly Gln Ala Thr Gln Ser Ala Gln Glu Lys
    850                 855                 860
Glu Lys Gln Gly Gln Met Glu Arg Thr His Asn Lys Gln Glu Lys Asn
865                 870                 875                 880
Arg Gly Glu Glu Lys Ser Lys Ser Glu Arg Glu Cys Pro His Ser Lys
                885                 890                 895
Lys Arg Thr Leu Lys Glu Asn Leu Ser Asp His Leu Arg Asn Gly Ser
            900                 905                 910
Lys Pro Lys Arg Lys Asn Tyr Ala Gly Ser Lys Trp Asp Ser Glu Ser
        915                 920                 925
Asn Ser Glu Arg Asp Val Thr Lys Asn Ser Lys Asn Asp Ser His Pro
    930                 935                 940
Ser Ser Asp Lys Glu Glu Gly Glu Ala Thr Ser Asp Ser Glu Ser Glu
945                 950                 955                 960
Val Ser Glu Ile His Ile Lys Val Lys Pro Thr Thr Lys Ser Ser Thr
                965                 970                 975
Asn Thr Ser Leu Pro Asp Asp Asn Gly Ala Trp Lys Ser Ser Lys Gln
            980                 985                 990
Arg Arg Ser Thr Ser Asp Ser Glu Gly Ser Cys Ser Asn Ser Glu Asn
        995                 1000                1005
Asn Arg Gly Lys Pro Gln Lys His Lys His Gly Ser Arg Lys Ser
    1010                1015                1020

<210> 1800
<211> 982
<212> PRT
<213> Homo sapiens

<400> 1800
Val Ala Ala Ala Ala Leu Ala Met Gly Ala Gln Asp Arg Pro Gln Cys
 1               5                  10                  15
His Phe Asp Ile Glu Ile Asn Arg Glu Pro Val Gly Arg Ile Met Phe
            20                  25                  30
Gln Leu Phe Ser Asp Ile Cys Pro Lys Thr Cys Lys Asn Phe Leu Cys
        35                  40                  45
Leu Cys Ser Gly Glu Lys Gly Leu Gly Lys Thr Thr Gly Lys Lys Leu
    50                  55                  60
Cys Tyr Lys Gly Ser Thr Phe His Arg Val Val Lys Asn Phe Met Ile
65                  70                  75                  80
Gln Gly Gly Asp Phe Ser Glu Gly Asn Gly Lys Gly Gly Glu Ser Ile
                85                  90                  95
Tyr Gly Gly Tyr Phe Lys Asp Glu Asn Phe Ile Leu Lys His Asp Arg
            100                 105                 110
Ala Phe Leu Leu Ser Met Ala Asn Arg Gly Lys His Thr Asn Gly Ser
        115                 120                 125
Gln Phe Phe Ile Thr Thr Lys Pro Ala Pro His Leu Asp Gly Val His
    130                 135                 140
Val Val Phe Gly Leu Val Ile Ser Gly Phe Glu Val Ile Glu Gln Val
145                 150                 155                 160
Glu Asn Leu Lys Thr Asp Ala Ala Ser Arg Pro Tyr Ala Asp Val Arg
                165                 170                 175
Val Ile Asp Cys Gly Val Leu Ala Thr Lys Leu Thr Lys Asp Val Phe
            180                 185                 190
Glu Lys Lys Arg Lys Lys Pro Thr Cys Ser Glu Gly Ser Asp Ser Ser
        195                 200                 205
Ser Arg Ser Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser Glu Val Glu
    210                 215                 220
Arg Glu Thr Ile Arg Arg Arg Arg His Lys Arg Arg Pro Lys Val Arg
225                 230                 235                 240
His Ala Lys Lys Arg Arg Lys Glu Met Ser Ser Ser Glu Glu Pro Arg
                245                 250                 255
Arg Lys Arg Thr Val Ser Pro Glu Gly Tyr Ser Glu Arg Ser Asp Val
            260                 265                 270
Asn Glu Lys Arg Ser Val Asp Ser Asn Thr Lys Arg Glu Lys Pro Val
        275                 280                 285
Val Arg Pro Glu Glu Ile Pro Pro Val Pro Glu Asn Arg Phe Leu Leu
    290                 295                 300
Arg Arg Asp Met Pro Ala Ile Thr Val Glu Pro Glu Gln Asn Ile Pro
305                 310                 315                 320
Asp Val Ala Pro Val Val Ser Asp Gln Lys Pro Ser Val Ser Lys Ser
                325                 330                 335
Gly Arg Lys Ile Lys Gly Arg Gly Thr Ile Arg Tyr His Thr Pro Pro
            340                 345                 350
Arg Ser Arg Ser His Ser Glu Ser Lys Asp Asp Asp Ser Ser Glu Thr
        355                 360                 365
Pro Pro His Trp Lys Glu Glu Met Gln Arg Leu Arg Ala Tyr Arg Pro
    370                 375                 380
Pro Ser Gly Glu Lys Trp Ser Lys Gly Asp Lys Leu Ser Asp Pro Cys
385                 390                 395                 400
Ser Ser Arg Trp Asp Glu Arg Ser Leu Ser Gln Arg Ser Arg Ser Trp
                405                 410                 415
Ser Tyr Asn Gly Tyr Tyr Ser Asp Leu Ser Thr Ala Arg His Ser Asp
            420                 425                 430
Gly His His Lys Lys His Arg Lys Glu Lys Lys Phe Lys His Lys Lys
        435                 440                 445
Lys Ala Lys Lys Gln Lys His Cys Arg Arg His Arg Gln Thr Lys Lys
    450                 455                 460
Arg Arg Ile Val Met Pro Asp Leu Glu Pro Ser Arg Ser Pro Thr His
465                 470                 475                 480
Arg Met Lys Ser Ser Cys Val Arg Glu Arg Arg Ser Arg Ala Ser Ser
                485                 490                 495
Ser Ser Ser His His Ser Ser Lys Arg Asp Trp Ser Lys Ser Asp Gln
            500                 505                 510
Asp Asp Gly Ser Ala Ser Thr His Ser Ser Arg Asp Ser Tyr Arg Ser
        515                 520                 525
Lys Ser His Ser Arg Ser Asp Ser Arg Gly Ser Ser Arg Ser Arg Ala
    530                 535                 540
Val Ser Lys Ser Ser Ser Arg Ser Leu Asn Arg Ser Lys Ser Arg Ser
545                 550                 555                 560
Ser Ser Arg Ser Gly Pro Arg Arg Thr Ser Ile Ser Pro Lys Lys Pro
                565                 570                 575
Ala Gln Leu Ser Glu Asn Lys Pro Val Lys Thr Glu Pro Leu Arg Pro
            580                 585                 590
Ser Val Pro Gln Asn Gly Asn Val Leu Val Gln Pro Val Ala Ala Glu
        595                 600                 605
Asn Ile Pro Val Ile Pro Leu Ser Asp Ser Pro Pro Pro Ser Arg Trp
    610                 615                 620
Lys Pro Gly Gln Lys Pro Trp Lys Pro Ser Tyr Glu Arg Ile Gln Glu
625                 630                 635                 640
Met Lys Ala Lys Thr Thr His Leu Leu Pro Val Gln Ser Thr Tyr Ser
                645                 650                 655
Leu Thr Asn Ile Lys Ala Thr Val Ser Ser Ser Ser Tyr His Lys Arg
            660                 665                 670
Glu Lys Pro Ser Glu Ser Asp Gly Ser Ala Tyr Ser Lys Tyr Ser Asp
        675                 680                 685
Arg Ser Ser Gly Ser Ser Gly Arg Ser Gly Ser Lys Ser Ser Arg Ser
    690                 695                 700
Arg Ser Ser Ser Arg Ser Tyr Thr Arg Ser Arg Ser Arg Ser Leu Pro
705                 710                 715                 720
Thr Ser Arg Ser Leu Ser Arg Ser Pro Ser Ser Arg Ser His Ser Pro
                725                 730                 735
Asn Lys Tyr Ser Asp Gly Ser Gln His Ser Arg Ser Ser Ser Tyr Thr
            740                 745                 750
Ser Val Ser Ser Asp Asp Gly Arg Arg Ala Met Phe Arg Ser Asn Arg
        755                 760                 765
Lys Lys Ser Val Thr Ser His Lys Arg His Arg Ser Asn Ser Glu Lys
    770                 775                 780
Thr Ile His Ser Lys Tyr Val Arg Gly Arg Glu Lys Ser Ser Arg His
785                 790                 795                 800
Arg Lys Tyr Ser Glu Ser Arg Ser Ser Leu Asp Tyr Thr Ser Asp Ser
                805                 810                 815
Asp Gln Ser His Val Gln Val Tyr Ser Ala Pro Glu Lys Glu Lys Gln
            820                 825                 830
Gly Lys Val Glu Ala Leu Asn Asp Lys Gln Gly Lys Gly Arg Glu Glu
        835                 840                 845
Gly Lys Pro Lys Pro Glu Trp Glu Cys Pro Arg Ser Lys Lys Glu Asn
    850                 855                 860
Ser Glu Asp His Ser Arg Asp Asp Ser Val Ser Lys Gly Lys Asn Cys
865                 870                 875                 880
Ala Gly Ser Lys Trp Asp Ser Glu Ser Asn Ser Glu Gln Asp Val Thr
                885                 890                 895
Lys Ser Arg Lys Ser Asp Pro Arg Arg Gly Ser Glu Lys Glu Glu Gly
            900                 905                 910
Glu Ala Ser Ser Asp Ser Glu Ser Glu Val Gly Gln Ser His Ile Lys
        915                 920                 925
Ala Lys Pro Pro Ala Lys Pro Pro Thr Ser Thr Phe Leu Pro Gly Ser
    930                 935                 940
Asp Gly Ala Trp Lys Ser Arg Arg Pro Gln Ser Ser Ala Ser Glu Ser
945                 950                 955                 960
Glu Ser Ser Cys Ser Asn Leu Gly Asn Ile Arg Gly Glu Pro Gln Lys
                965                 970                 975
Gln Lys Thr Leu Lys Gly
            980

<210> 1801
<211> 1462
<212> PRT
<213> Homo sapiens

<400> 1801
Met Gly Ala Gln Asp Arg Pro Gln Cys His Phe Asp Ile Glu Ile Asn
 1               5                  10                  15
Arg Glu Pro Val Gly Arg Ile Met Phe Gln Leu Phe Ser Asp Ile Cys
            20                  25                  30
Pro Lys Thr Cys Lys Asn Phe Leu Cys Leu Cys Ser Gly Glu Lys Gly
        35                  40                  45
Leu Gly Lys Thr Thr Gly Lys Lys Leu Cys Tyr Lys Gly Ser Thr Phe
    50                  55                  60
His Arg Val Val Lys Asn Phe Met Ile Gln Gly Gly Asp Phe Ser Glu
65                  70                  75                  80
Gly Asn Gly Lys Gly Gly Glu Ser Ile Tyr Gly Gly Tyr Phe Lys Asp
                85                  90                  95
Glu Asn Phe Ile Leu Lys His Asp Arg Ala Phe Leu Leu Ser Met Ala
            100                 105                 110
Asn Arg Gly Lys His Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Lys
        115                 120                 125
Pro Ala Pro His Leu Asp Gly Val His Val Val Phe Gly Leu Val Ile
    130                 135                 140
Ser Gly Phe Glu Val Ile Glu Gln Ile Glu Asn Leu Lys Thr Asp Ala
145                 150                 155                 160
Ala Ser Arg Pro Tyr Ala Asp Val Arg Val Ile Asp Cys Gly Val Leu
                165                 170                 175
Ala Thr Lys Ser Ile Lys Asp Val Phe Glu Lys Lys Arg Lys Lys Pro
            180                 185                 190
Thr His Ser Glu Gly Ser Asp Ser Ser Ser Asn Ser Ser Ser Ser Ser
        195                 200                 205
Glu Ser Ser Ser Glu Ser Glu Leu Glu His Glu Arg Ser Arg Arg Arg
    210                 215                 220
Lys His Lys Arg Arg Pro Lys Val Lys Arg Ser Lys Lys Arg Arg Lys
225                 230                 235                 240
Glu Ala Ser Ser Ser Glu Glu Pro Arg Asn Lys His Ala Met Asn Pro
                245                 250                 255
Lys Gly His Ser Glu Arg Ser Asp Thr Asn Glu Lys Arg Ser Val Asp
            260                 265                 270
Ser Ser Ala Lys Arg Glu Lys Pro Val Val Arg Pro Glu Glu Ile Pro
        275                 280                 285
Pro Val Pro Glu Asn Arg Phe Leu Leu Arg Arg Asp Met Pro Val Val
    290                 295                 300
Thr Ala Glu Pro Glu Pro Lys Ile Pro Asp Val Ala Pro Ile Val Ser
305                 310                 315                 320
Asp Gln Lys Pro Ser Val Ser Lys Ser Gly Arg Lys Ile Lys Gly Arg
                325                 330                 335
Gly Thr Ile Arg Tyr His Thr Pro Pro Arg Ser Arg Ser Cys Ser Glu
            340                 345                 350
Ser Asp Asp Asp Asp Ser Ser Glu Thr Pro Pro His Trp Lys Glu Glu
        355                 360                 365
Met Gln Arg Leu Arg Ala Tyr Arg Pro Pro Ser Gly Glu Lys Trp Ser
    370                 375                 380
Lys Gly Asp Lys Leu Ser Asp Pro Cys Ser Ser Arg Trp Asp Glu Arg
385                 390                 395                 400
Ser Leu Ser Gln Arg Ser Arg Ser Trp Ser Tyr Asn Gly Tyr Tyr Ser
                405                 410                 415
Asp Leu Ser Thr Ala Arg His Ser Gly His His Lys Lys Arg Arg Lys
            420                 425                 430
Glu Lys Lys Val Lys His Lys Lys Lys Gly Lys Lys Gln Lys His Cys
        435                 440                 445
Arg Arg His Lys Gln Thr Lys Lys Arg Arg Ile Leu Ile Pro Ser Asp
    450                 455                 460
Ile Glu Ser Ser Lys Ser Ser Thr Arg Arg Met Lys Ser Ser Cys Asp
465                 470                 475                 480
Arg Glu Arg Ser Ser Arg Ser Ser Ser Leu Ser Ser His His Ser Ser
                485                 490                 495
Lys Arg Asp Trp Ser Lys Ser Asp Lys Asp Val Gln Ser Ser Leu Thr
            500                 505                 510
His Ser Ser Arg Asp Ser Tyr Arg Ser Lys Ser His Ser Gln Ser Tyr
        515                 520                 525
Ser Arg Gly Ser Ser Arg Ser Arg Thr Ala Ser Lys Ser Ser Ser His
    530                 535                 540
Ser Arg Ser Arg Ser Lys Ser Arg Ser Ser Ser Lys Ser Gly His Arg
545                 550                 555                 560
Lys Arg Ala Ser Lys Ser Pro Arg Lys Thr Ala Ser Gln Leu Ser Glu
                565                 570                 575
Asn Lys Pro Val Lys Thr Glu Pro Leu Arg Ala Thr Met Ala Gln Asn
            580                 585                 590
Glu Asn Val Val Val Gln Pro Val Val Ala Glu Asn Ile Pro Val Ile
        595                 600                 605
Pro Leu Ser Asp Ser Pro Pro Pro Ser Arg Trp Lys Pro Gly Gln Lys
    610                 615                 620
Pro Trp Lys Pro Ser Tyr Glu Arg Ile Gln Glu Met Lys Ala Lys Thr
625                 630                 635                 640
Thr His Leu Leu Pro Ile Gln Ser Thr Tyr Ser Leu Ala Asn Ile Lys
                645                 650                 655
Glu Thr Gly Ser Ser Ser Ser Tyr His Lys Arg Glu Lys Asn Ser Glu
            660                 665                 670
Ser Asp Gln Ser Thr Tyr Ser Lys Tyr Ser Asp Arg Ser Ser Glu Ser
        675                 680                 685
Ser Pro Arg Ser Arg Ser Arg Ser Ser Arg Ser Arg Ser Tyr Ser Arg
    690                 695                 700
Ser Tyr Thr Arg Ser Arg Ser Leu Ala Ser Ser His Ser Arg Ser Arg
705                 710                 715                 720
Ser Pro Ser Ser Arg Ser His Ser Arg Asn Lys Tyr Ser Asp His Ser
                725                 730                 735
Gln Cys Ser Arg Ser Ser Ser Tyr Thr Ser Ile Ser Ser Asp Asp Gly
            740                 745                 750
Arg Arg Ala Lys Arg Arg Leu Arg Ser Ser Gly Lys Lys Asn Ser Val
        755                 760                 765
Ser His Lys Lys His Ser Ser Ser Ser Glu Lys Thr Leu His Ser Lys
    770                 775                 780
Tyr Val Lys Gly Arg Asp Arg Ser Ser Cys Val Arg Lys Tyr Ser Glu
785                 790                 795                 800
Ser Arg Ser Ser Leu Asp Tyr Ser Ser Asp Ser Glu Gln Ser Ser Val
                805                 810                 815
Gln Ala Thr Gln Ser Ala Gln Glu Lys Glu Lys Gln Gly Gln Met Glu
            820                 825                 830
Arg Thr His Asn Lys Gln Glu Lys Asn Arg Gly Glu Glu Lys Ser Lys
        835                 840                 845
Ser Glu Arg Glu Cys Pro His Ser Lys Lys Arg Thr Leu Lys Glu Asn
    850                 855                 860
Leu Ser Asp His Leu Arg Asn Gly Ser Lys Pro Lys Arg Lys Asn Tyr
865                 870                 875                 880
Ala Gly Ser Lys Trp Asp Ser Glu Ser Asn Ser Glu Arg Asp Val Thr
                885                 890                 895
Lys Asn Ser Lys Asn Asp Ser His Pro Ser Ser Asp Lys Glu Glu Gly
            900                 905                 910
Glu Ala Thr Ser Asp Ser Glu Ser Glu Val Ser Glu Ile His Ile Lys
        915                 920                 925
Val Lys Pro Thr Thr Lys Ser Ser Thr Asn Thr Ser Leu Pro Asp Asp
    930                 935                 940
Asn Gly Ala Trp Lys Ser Ser Lys Gln Arg Thr Ser Thr Ser Asp Ser
945                 950                 955                 960
Glu Gly Ser Cys Ser Asn Ser Glu Asn Asn Arg Gly Lys Pro Gln Lys
                965                 970                 975
His Lys His Gly Ser Lys Glu Asn Leu Lys Arg Glu His Thr Lys Lys
            980                 985                 990
Val Lys Glu Lys Leu Lys Gly Lys Lys Asp Lys Lys His Lys Ala Pro
        995                 1000                1005
Lys Arg Lys Gln Ala Phe His Trp Gln Pro Pro Leu Glu Phe Gly Glu
    1010                1015                1020
Glu Glu Glu Glu Glu Ile Asp Asp Lys Gln Val Thr Gln Glu Ser Lys
1025                1030                1035                1040
Glu Lys Lys Val Ser Glu Asn Asn Glu Thr Ile Lys Asp Asn Ile Leu
                1045                1050                1055
Lys Thr Glu Lys Ser Ser Glu Glu Asp Leu Ser Gly Lys His Asp Thr
            1060                1065                1070
Val Thr Val Ser Ser Asp Leu Asp Gln Phe Thr Lys Asp Asp Ser Lys
        1075                1080                1085
Leu Ser Ile Ser Pro Thr Ala Leu Asn Thr Glu Glu Asn Val Ala Cys
    1090                1095                1100
Leu Gln Asn Ile Gln His Val Glu Glu Ser Val Pro Asn Gly Val Glu
1105                1110                1115                1120
Asp Val Leu Gln Thr Asp Asp Asn Met Glu Ile Cys Thr Pro Asp Arg
                1125                1130                1135
Ser Ser Pro Ala Lys Val Glu Glu Thr Ser Pro Leu Gly Asn Ala Arg
            1140                1145                1150
Leu Asp Thr Pro Asp Ile Asn Ile Val Leu Lys Gln Asp Met Ala Thr
        1155                1160                1165
Glu His Pro Gln Ala Glu Val Val Lys Gln Glu Ser Ser Met Ser Glu
    1170                1175                1180
Ser Lys Val Leu Gly Glu Val Gly Lys Gln Asp Ser Ser Ser Ala Ser
1185                1190                1195                1200
Leu Ala Ser Ala Gly Glu Ser Thr Gly Lys Lys Glu Val Ala Glu Lys
                1205                1210                1215
Ser Gln Ile Asn Leu Ile Asp Lys Lys Trp Lys Pro Leu Gln Gly Val
            1220                1225                1230
Gly Asn Leu Ala Ala Pro Asn Ala Ala Thr Ser Ser Ala Val Glu Val
        1235                1240                1245
Lys Val Leu Thr Thr Val Pro Glu Met Lys Pro Gln Gly Leu Arg Ile
    1250                1255                1260
Glu Ile Lys Ser Lys Asn Lys Val Arg Pro Gly Ser Leu Phe Asp Glu
1265                1270                1275                1280
Val Arg Lys Thr Ala Arg Leu Asn Arg Arg Pro Arg Asn Gln Glu Ser
                1285                1290                1295
Ser Ser Asp Glu Gln Thr Pro Ser Arg Asp Asp Asp Ser Gln Ser Arg
            1300                1305                1310
Ser Pro Ser Arg Ser Arg Ser Lys Ser Glu Thr Lys Ser Arg His Arg
        1315                1320                1325
Thr Arg Ser Val Ser Tyr Ser His Ser Arg Ser Arg Ser Arg Ser Ser
    1330                1335                1340
Thr Ser Ser Tyr Arg Ser Arg Ser Tyr Ser Arg Ser Arg Ser Arg Gly
1345                1350                1355                1360
Trp Tyr Ser Arg Gly Arg Thr Arg Ser Arg Ser Ser Ser Tyr Arg Ser
                1365                1370                1375
Tyr Lys Ser His Arg Thr Ser Ser Arg Ser Arg Ser Arg Ser Ser Ser
            1380                1385                1390
Tyr Asp Pro His Ser Arg Ser Arg Ser Tyr Thr Tyr Asp Ser Tyr Tyr
        1395                1400                1405
Ser Arg Ser Arg Ser Arg Ser Arg Ser Gln Arg Ser Asp Ser Tyr His
    1410                1415                1420
Arg Gly Arg Ser Tyr Asn Arg Arg Ser Arg Ser Cys Arg Ser Tyr Gly
1425                1430                1435                1440
Ser Asp Ser Glu Ser Asp Arg Ser Tyr Ser His His Arg Ser Pro Ser
                1445                1450                1455
Glu Ser Ser Arg Tyr Ser
            1460

<210> 1802
<211> 1462
<212> PRT
<213> Homo sapiens

<400> 1802
Met Gly Ala Gln Asp Arg Pro Gln Cys His Phe Asp Ile Glu Ile Asn
 1               5                  10                  15
Arg Glu Pro Val Gly Arg Ile Met Phe Gln Leu Phe Ser Asp Ile Cys
            20                  25                  30
Pro Lys Thr Cys Lys Asn Phe Leu Cys Leu Cys Ser Gly Glu Lys Gly
        35                  40                  45
Leu Gly Lys Thr Thr Gly Lys Lys Leu Cys Tyr Lys Gly Ser Thr Phe
    50                  55                  60
His Arg Val Val Lys Asn Phe Met Ile Gln Gly Gly Asp Phe Ser Glu
65                  70                  75                  80
Gly Asn Gly Lys Gly Gly Glu Ser Ile Tyr Gly Gly Tyr Phe Lys Asp
                85                  90                  95
Glu Asn Phe Ile Leu Lys His Asp Arg Ala Phe Leu Leu Ser Met Ala
            100                 105                 110
Asn Arg Gly Lys His Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Lys
        115                 120                 125
Pro Ala Pro His Leu Asp Gly Val His Val Val Phe Gly Leu Val Ile
    130                 135                 140
Ser Gly Phe Glu Val Ile Glu Gln Ile Glu Asn Leu Lys Thr Asp Ala
145                 150                 155                 160
Ala Ser Arg Pro Tyr Ala Asp Val Arg Val Ile Asp Cys Gly Val Leu
                165                 170                 175
Ala Thr Lys Ser Ile Lys Asp Val Phe Glu Lys Lys Arg Lys Lys Pro
            180                 185                 190
Thr His Ser Glu Gly Ser Asp Ser Ser Ser Asn Ser Ser Ser Ser Ser
        195                 200                 205
Glu Ser Ser Ser Glu Ser Glu Leu Glu His Glu Arg Ser Arg Arg Arg
    210                 215                 220
Lys His Lys Arg Arg Pro Lys Val Lys Arg Ser Lys Lys Arg Arg Lys
225                 230                 235                 240
Glu Ala Ser Ser Ser Glu Glu Pro Arg Asn Lys His Ala Met Asn Pro
                245                 250                 255
Lys Gly His Ser Glu Arg Ser Asp Thr Asn Glu Lys Arg Ser Val Asp
            260                 265                 270
Ser Ser Ala Lys Arg Glu Lys Pro Val Val Arg Pro Glu Glu Ile Pro
        275                 280                 285
Pro Val Pro Glu Asn Arg Phe Leu Leu Arg Arg Asp Met Pro Val Val
    290                 295                 300
Thr Ala Glu Pro Glu Pro Lys Ile Pro Asp Val Ala Pro Ile Val Ser
305                 310                 315                 320
Asp Gln Lys Pro Ser Val Ser Lys Ser Gly Arg Lys Ile Lys Gly Arg
                325                 330                 335
Gly Thr Ile Arg Tyr His Thr Pro Pro Arg Ser Arg Ser Cys Ser Glu
            340                 345                 350
Ser Asp Asp Asp Asp Ser Ser Glu Thr Pro Pro His Trp Lys Glu Glu
        355                 360                 365
Met Gln Arg Leu Arg Ala Tyr Arg Pro Pro Ser Gly Glu Lys Trp Ser
    370                 375                 380
Lys Gly Asp Lys Leu Ser Asp Pro Cys Ser Ser Arg Trp Asp Glu Arg
385                 390                 395                 400
Ser Leu Ser Gln Arg Ser Arg Ser Trp Ser Tyr Asn Gly Tyr Tyr Ser
                405                 410                 415
Asp Leu Ser Thr Ala Arg His Ser Gly His His Lys Lys Arg Arg Lys
            420                 425                 430
Glu Lys Lys Val Lys His Lys Lys Lys Gly Lys Lys Gln Lys His Cys
        435                 440                 445
Arg Arg His Lys Gln Thr Lys Lys Arg Arg Ile Leu Ile Pro Ser Asp
    450                 455                 460
Ile Glu Ser Ser Lys Ser Ser Thr Arg Arg Met Lys Ser Ser Cys Asp
465                 470                 475                 480
Arg Glu Arg Ser Ser Arg Ser Ser Ser Leu Ser Ser His His Ser Ser
                485                 490                 495
Lys Arg Asp Trp Ser Lys Ser Asp Lys Asp Val Gln Ser Ser Leu Thr
            500                 505                 510
His Ser Ser Arg Asp Ser Tyr Arg Ser Lys Ser His Ser Gln Ser Tyr
        515                 520                 525
Ser Arg Gly Ser Ser Arg Ser Arg Thr Ala Ser Lys Ser Ser Ser His
    530                 535                 540
Ser Arg Ser Arg Ser Lys Ser Arg Ser Ser Ser Lys Ser Gly His Arg
545                 550                 555                 560
Lys Arg Ala Ser Lys Ser Pro Arg Lys Thr Ala Ser Gln Leu Ser Glu
                565                 570                 575
Asn Lys Pro Val Lys Thr Glu Pro Leu Arg Ala Thr Met Ala Gln Asn
            580                 585                 590
Glu Asn Val Val Val Gln Pro Val Val Ala Glu Asn Ile Pro Val Ile
        595                 600                 605
Pro Leu Ser Asp Ser Pro Pro Pro Ser Arg Trp Lys Pro Gly Gln Lys
    610                 615                 620
Pro Trp Lys Pro Ser Tyr Glu Arg Ile Gln Glu Met Lys Ala Lys Thr
625                 630                 635                 640
Thr His Leu Leu Pro Ile Gln Ser Thr Tyr Ser Leu Ala Asn Ile Lys
                645                 650                 655
Glu Thr Gly Ser Ser Ser Ser Tyr His Lys Arg Glu Lys Asn Ser Glu
            660                 665                 670
Ser Asp Gln Ser Thr Tyr Ser Lys Tyr Ser Asp Arg Ser Ser Glu Ser
        675                 680                 685
Ser Pro Arg Ser Arg Ser Arg Ser Ser Arg Ser Arg Ser Tyr Ser Arg
    690                 695                 700
Ser Tyr Thr Arg Ser Arg Ser Leu Ala Ser Ser His Ser Arg Ser Arg
705                 710                 715                 720
Ser Pro Ser Ser Arg Ser His Ser Arg Asn Lys Tyr Ser Asp His Ser
                725                 730                 735
Gln Cys Ser Arg Ser Ser Ser Tyr Thr Ser Ile Ser Ser Asp Asp Gly
            740                 745                 750
Arg Arg Ala Lys Arg Arg Leu Arg Ser Ser Gly Lys Lys Asn Ser Val
        755                 760                 765
Ser His Lys Lys His Ser Ser Ser Ser Glu Lys Thr Leu His Ser Lys
    770                 775                 780
Tyr Val Lys Gly Arg Asp Arg Ser Ser Cys Val Arg Lys Tyr Ser Glu
785                 790                 795                 800
Ser Arg Ser Ser Leu Asp Tyr Ser Ser Asp Ser Glu Gln Ser Ser Val
                805                 810                 815
Gln Ala Thr Gln Ser Ala Gln Glu Lys Glu Lys Gln Gly Gln Met Glu
            820                 825                 830
Arg Thr His Asn Lys Gln Glu Lys Asn Arg Gly Glu Glu Lys Ser Lys
        835                 840                 845
Ser Glu Arg Glu Cys Pro His Ser Lys Lys Arg Thr Leu Lys Glu Asn
    850                 855                 860
Leu Ser Asp His Leu Arg Asn Gly Ser Lys Pro Lys Arg Lys Asn Tyr
865                 870                 875                 880
Ala Gly Ser Lys Trp Asp Ser Glu Ser Asn Ser Glu Arg Asp Val Thr
                885                 890                 895
Lys Asn Ser Lys Asn Asp Ser His Pro Ser Ser Asp Lys Glu Glu Gly
            900                 905                 910
Glu Ala Thr Ser Asp Ser Glu Ser Glu Val Ser Glu Ile His Ile Lys
        915                 920                 925
Val Lys Pro Thr Thr Lys Ser Ser Thr Asn Thr Ser Leu Pro Asp Asp
    930                 935                 940
Asn Gly Ala Trp Lys Ser Ser Lys Gln Arg Thr Ser Thr Ser Asp Ser
945                 950                 955                 960
Glu Gly Ser Cys Ser Asn Ser Glu Asn Asn Arg Gly Lys Pro Gln Lys
                965                 970                 975
His Lys His Gly Ser Lys Glu Asn Leu Lys Arg Glu His Thr Lys Lys
            980                 985                 990
Val Lys Glu Lys Leu Lys Gly Lys Lys Asp Lys Lys His Lys Ala Pro
        995                 1000                1005
Lys Arg Lys Gln Ala Phe His Trp Gln Pro Pro Leu Glu Phe Gly Glu
    1010                1015                1020
Glu Glu Glu Glu Glu Ile Asp Asp Lys Gln Val Thr Gln Glu Ser Lys
1025                1030                1035                1040
Glu Lys Lys Val Ser Glu Asn Asn Glu Thr Ile Lys Asp Asn Ile Leu
                1045                1050                1055
Lys Thr Glu Lys Ser Ser Glu Glu Asp Leu Ser Gly Lys His Asp Thr
            1060                1065                1070
Val Thr Val Ser Ser Asp Leu Asp Gln Phe Thr Lys Asp Asp Ser Lys
        1075                1080                1085
Leu Ser Ile Ser Pro Thr Ala Leu Asn Thr Glu Glu Asn Val Ala Cys
    1090                1095                1100
Leu Gln Asn Ile Gln His Val Glu Glu Ser Val Pro Asn Gly Val Glu
1105                1110                1115                1120
Asp Val Leu Gln Thr Asp Asp Asn Met Glu Ile Cys Thr Pro Asp Arg
                1125                1130                1135
Ser Ser Pro Ala Lys Val Glu Glu Thr Ser Pro Leu Gly Asn Ala Arg
            1140                1145                1150
Leu Asp Thr Pro Asp Ile Asn Ile Val Leu Lys Gln Asp Met Ala Thr
        1155                1160                1165
Glu His Pro Gln Ala Glu Val Val Lys Gln Glu Ser Ser Met Ser Glu
    1170                1175                1180
Ser Lys Val Leu Gly Glu Val Gly Lys Gln Asp Ser Ser Ser Ala Ser
1185                1190                1195                1200
Leu Ala Ser Ala Gly Glu Ser Thr Gly Lys Lys Glu Val Ala Glu Lys
                1205                1210                1215
Ser Gln Ile Asn Leu Ile Asp Lys Lys Trp Lys Pro Leu Gln Gly Val
            1220                1225                1230
Gly Asn Leu Ala Ala Pro Asn Ala Ala Thr Ser Ser Ala Val Glu Val
        1235                1240                1245
Lys Val Leu Thr Thr Val Pro Glu Met Lys Pro Gln Gly Leu Arg Ile
    1250                1255                1260
Glu Ile Lys Ser Lys Asn Lys Val Arg Pro Gly Ser Leu Phe Asp Glu
1265                1270                1275                1280
Val Arg Lys Thr Ala Arg Leu Asn Arg Arg Pro Arg Asn Gln Glu Ser
                1285                1290                1295
Ser Ser Asp Glu Gln Thr Pro Ser Arg Asp Asp Asp Ser Gln Ser Arg
            1300                1305                1310
Ser Pro Ser Arg Ser Arg Ser Lys Ser Glu Thr Lys Ser Arg His Arg
        1315                1320                1325
Thr Arg Ser Val Ser Tyr Ser His Ser Arg Ser Arg Ser Arg Ser Ser
    1330                1335                1340
Thr Ser Ser Tyr Arg Ser Arg Ser Tyr Ser Arg Ser Arg Ser Arg Gly
1345                1350                1355                1360
Trp Tyr Ser Arg Gly Arg Thr Arg Ser Arg Ser Ser Ser Tyr Arg Ser
                1365                1370                1375
Tyr Lys Ser His Arg Thr Ser Ser Arg Ser Arg Ser Arg Ser Ser Ser
            1380                1385                1390
Tyr Asp Pro His Ser Arg Ser Arg Ser Tyr Thr Tyr Asp Ser Tyr Tyr
        1395                1400                1405
Ser Arg Ser Arg Ser Arg Ser Arg Ser Gln Arg Ser Asp Ser Tyr His
    1410                1415                1420
Arg Gly Arg Ser Tyr Asn Arg Arg Ser Arg Ser Cys Arg Ser Tyr Gly
1425                1430                1435                1440
Ser Asp Ser Glu Ser Asp Arg Ser Tyr Ser His His Arg Ser Pro Ser
                1445                1450                1455
Glu Ser Ser Arg Tyr Ser
            1460

<210> 1803
<211> 1219
<212> PRT
<213> Homo sapiens

<400> 1803
Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln
 1               5                  10                  15
Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu
            20                  25                  30
Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys
        35                  40                  45
Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg
    50                  55                  60
Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu
65                  70                  75                  80
Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Ala
                85                  90                  95
Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala
            100                 105                 110
Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn
        115                 120                 125
Thr Ser Tyr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu Gln Leu
    130                 135                 140
Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu Gln Ile
145                 150                 155                 160
His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn
                165                 170                 175
Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu
            180                 185                 190
Asp Ile Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro
        195                 200                 205
Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met
    210                 215                 220
Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile
225                 230                 235                 240
Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val Glu
                245                 250                 255
Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp Leu
            260                 265                 270
Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr Lys
        275                 280                 285
Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser Pro
    290                 295                 300
Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys Met
305                 310                 315                 320
Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro Gly
                325                 330                 335
Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu Phe
            340                 345                 350
Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp Ser
        355                 360                 365
Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe Thr
    370                 375                 380
Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe
385                 390                 395                 400
Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly
                405                 410                 415
Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg
            420                 425                 430
Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys
        435                 440                 445
Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met
    450                 455                 460
His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly
465                 470                 475                 480
Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro Phe
                485                 490                 495
Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile Trp
            500                 505                 510
Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser Ala
        515                 520                 525
Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys Ala
    530                 535                 540
Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe Phe
545                 550                 555                 560
Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala Arg
                565                 570                 575
Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu Pro
            580                 585                 590
Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg
        595                 600                 605
Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys Arg
    610                 615                 620
Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly
625                 630                 635                 640
Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val
                645                 650                 655
Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala
            660                 665                 670
Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser
        675                 680                 685
Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp
    690                 695                 700
Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala
705                 710                 715                 720
Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp
                725                 730                 735
Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala
            740                 745                 750
Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val
        755                 760                 765
Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe
    770                 775                 780
Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys
785                 790                 795                 800
Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu
                805                 810                 815
Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg
            820                 825                 830
Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro
        835                 840                 845
Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu
    850                 855                 860
Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu
865                 870                 875                 880
Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala
                885                 890                 895
Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe
            900                 905                 910
Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe
        915                 920                 925
Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys
    930                 935                 940
Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His
945                 950                 955                 960
Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys
                965                 970                 975
Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro
            980                 985                 990
Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr Val
        995                 1000                1005
Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn Gln
    1010                1015                1020
Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro Gly
1025                1030                1035                1040
Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln Gly
                1045                1050                1055
Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu Gly
            1060                1065                1070
Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys Gln
        1075                1080                1085
Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr Thr
    1090                1095                1100
Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe Val
1105                1110                1115                1120
Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu Thr
                1125                1130                1135
Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu Arg
            1140                1145                1150
Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly Pro
        1155                1160                1165
Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser Phe
    1170                1175                1180
Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala
1185                1190                1195                1200
Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu
                1205                1210                1215
Trp Gly Leu


<210> 1804
<211> 1060
<212> PRT
<213> Homo sapiens

<400> 1804
Ile Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val
 1               5                  10                  15
Glu Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp
            20                  25                  30
Leu Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr
        35                  40                  45
Lys Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser
    50                  55                  60
Pro Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys
65                  70                  75                  80
Met Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro
                85                  90                  95
Gly Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu
            100                 105                 110
Phe Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp
        115                 120                 125
Ser Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe
    130                 135                 140
Thr Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val
145                 150                 155                 160
Phe Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu
                165                 170                 175
Gly Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His
            180                 185                 190
Arg Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg
        195                 200                 205
Lys Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser
    210                 215                 220
Met His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser
225                 230                 235                 240
Gly Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro
                245                 250                 255
Phe Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile
            260                 265                 270
Trp Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser
        275                 280                 285
Ala Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys
    290                 295                 300
Ala Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe
305                 310                 315                 320
Phe Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala
                325                 330                 335
Arg Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu
            340                 345                 350
Pro Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala
        355                 360                 365
Arg Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys
    370                 375                 380
Arg Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg
385                 390                 395                 400
Gly Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg
                405                 410                 415
Val Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly
            420                 425                 430
Ala Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala
        435                 440                 445
Ser Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln
    450                 455                 460
Asp Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp
465                 470                 475                 480
Ala Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr
                485                 490                 495
Asp Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val
            500                 505                 510
Ala Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser
        515                 520                 525
Val Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe
    530                 535                 540
Phe Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu
545                 550                 555                 560
Lys Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser
                565                 570                 575
Leu Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro
            580                 585                 590
Arg Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser
        595                 600                 605
Pro Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser
    610                 615                 620
Glu Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg
625                 630                 635                 640
Leu Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg
                645                 650                 655
Ala Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn
            660                 665                 670
Phe Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp
        675                 680                 685
Phe Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro
    690                 695                 700
Lys Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His
705                 710                 715                 720
His Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly
                725                 730                 735
Cys Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln
            740                 745                 750
Pro Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr
        755                 760                 765
Val Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn
    770                 775                 780
Gln Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro
785                 790                 795                 800
Gly Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln
                805                 810                 815
Gly Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu
            820                 825                 830
Gly Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys
        835                 840                 845
Gln Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr
    850                 855                 860
Thr Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe
865                 870                 875                 880
Val Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu
                885                 890                 895
Thr Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu
            900                 905                 910
Arg Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly
        915                 920                 925
Pro Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser
    930                 935                 940
Phe Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp
945                 950                 955                 960
Ala Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser
                965                 970                 975
Glu Trp Gly Glu Pro His Gly Arg Asp Ile Ala Gly Gln Gln Ala Thr
            980                 985                 990
Gly Ala Pro Gly Gly Pro Leu Ser Ala Gly Cys Val Cys Gln Gly Cys
        995                 1000                1005
Gly Ala Glu Asp Val Val Pro Phe Gln Cys Pro Ala Cys Asp Phe Gln
    1010                1015                1020
Arg Cys Gln Ala Cys Trp Gln Arg His Leu Gln Ala Ser Arg Met Cys
1025                1030                1035                1040
Pro Ala Cys His Thr Ala Ser Arg Lys Gln Ser Val Met Gln Val Phe
                1045                1050                1055
Trp Pro Glu Pro
            1060

<210> 1805
<211> 1161
<212> PRT
<213> Homo sapiens

<400> 1805
Ile Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val
 1               5                  10                  15
Glu Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp
            20                  25                  30
Leu Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr
        35                  40                  45
Lys Ala Ala His Glu Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser
    50                  55                  60
Pro Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys
65                  70                  75                  80
Met Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro
                85                  90                  95
Gly Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu
            100                 105                 110
Phe Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp
        115                 120                 125
Ser Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe
    130                 135                 140
Thr Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val
145                 150                 155                 160
Phe Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu
                165                 170                 175
Gly Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His
            180                 185                 190
Arg Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg
        195                 200                 205
Lys Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser
    210                 215                 220
Met His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser
225                 230                 235                 240
Gly Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro
                245                 250                 255
Phe Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile
            260                 265                 270
Trp Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser
        275                 280                 285
Ala Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys
    290                 295                 300
Ala Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe
305                 310                 315                 320
Phe Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala
                325                 330                 335
Arg Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu
            340                 345                 350
Pro Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala
        355                 360                 365
Arg Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys
    370                 375                 380
Arg Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg
385                 390                 395                 400
Gly Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg
                405                 410                 415
Val Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly
            420                 425                 430
Ala Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala
        435                 440                 445
Ser Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln
    450                 455                 460
Asp Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp
465                 470                 475                 480
Ala Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr
                485                 490                 495
Asp Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val
            500                 505                 510
Ala Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser
        515                 520                 525
Val Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe
    530                 535                 540
Phe Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu
545                 550                 555                 560
Lys Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser
                565                 570                 575
Leu Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro
            580                 585                 590
Arg Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser
        595                 600                 605
Pro Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser
    610                 615                 620
Glu Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg
625                 630                 635                 640
Leu Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg
                645                 650                 655
Ala Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn
            660                 665                 670
Phe Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp
        675                 680                 685
Phe Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro
    690                 695                 700
Lys Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His
705                 710                 715                 720
His Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly
                725                 730                 735
Cys Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln
            740                 745                 750
Pro Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr
        755                 760                 765
Val Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn
    770                 775                 780
Gln Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro
785                 790                 795                 800
Gly Ser His Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln
                805                 810                 815
Gly Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu
            820                 825                 830
Gly Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys
        835                 840                 845
Gln Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr
    850                 855                 860
Thr Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe
865                 870                 875                 880
Val Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu
                885                 890                 895
Thr Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu
            900                 905                 910
Arg Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly
        915                 920                 925
Pro Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser
    930                 935                 940
Phe Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp
945                 950                 955                 960
Ala Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser
                965                 970                 975
Glu Trp Gly Glu Pro His Gly Arg Asp Ile Ala Gly Gln Gln Ala Thr
            980                 985                 990
Gly Ala Pro Gly Gly Pro Leu Ser Ala Gly Cys Val Cys Gln Gly Cys
        995                 1000                1005
Gly Ala Glu Asp Val Val Pro Phe Gln Cys Pro Ala Cys Asp Phe Gln
    1010                1015                1020
Arg Cys Gln Ala Cys Trp Gln Arg His Leu Gln Ala Ser Arg Met Cys
1025                1030                1035                1040
Pro Ala Cys His Thr Ala Ser Arg Lys Gln Ser Val Met Gln Val Phe
                1045                1050                1055
Trp Pro Glu Pro His Lys Asp His Glu Gly Ala Gly Gly Ala Arg Pro
            1060                1065                1070
Val Ala Ala Val Pro Gly Val Gly Ala Ala Cys Pro Ala Ala Gly Ala
        1075                1080                1085
Gly Cys Thr Arg Ser Gly Arg Asn Thr His Leu Pro Leu Ala Gly Arg
    1090                1095                1100
Arg Asp Arg Gly Ala Ala Gly Val Arg Pro Val Pro Pro Arg His Leu
1105                1110                1115                1120
Cys Ala Ala Ala Val Pro Pro Arg Gln Pro His Asp Val Trp Pro Val
                1125                1130                1135
Ser Thr Ala Pro Leu His Ala Val Leu Glu Leu Pro Gly Ala Leu Pro
            1140                1145                1150
Leu Leu Gln Arg Pro Leu Arg Gly Ala
        1155                1160

<210> 1806
<211> 1219
<212> PRT
<213> Homo sapiens

<400> 1806
Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln
 1               5                  10                  15
Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu
            20                  25                  30
Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys
        35                  40                  45
Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg
    50                  55                  60
Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu
65                  70                  75                  80
Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Ala
                85                  90                  95
Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala
            100                 105                 110
Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn
        115                 120                 125
Thr Ser Tyr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu Gln Leu
    130                 135                 140
Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu Gln Ile
145                 150                 155                 160
His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn
                165                 170                 175
Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu
            180                 185                 190
Asp Ile Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro
        195                 200                 205
Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met
    210                 215                 220
Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile
225                 230                 235                 240
Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val Glu
                245                 250                 255
Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp Leu
            260                 265                 270
Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr Lys
        275                 280                 285
Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser Pro
    290                 295                 300
Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys Met
305                 310                 315                 320
Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro Gly
                325                 330                 335
Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu Phe
            340                 345                 350
Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp Ser
        355                 360                 365
Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe Thr
    370                 375                 380
Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe
385                 390                 395                 400
Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly
                405                 410                 415
Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg
            420                 425                 430
Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys
        435                 440                 445
Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met
    450                 455                 460
His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly
465                 470                 475                 480
Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro Phe
                485                 490                 495
Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile Trp
            500                 505                 510
Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser Ala
        515                 520                 525
Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys Ala
    530                 535                 540
Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe Phe
545                 550                 555                 560
Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala Arg
                565                 570                 575
Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu Pro
            580                 585                 590
Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg
        595                 600                 605
Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys Arg
    610                 615                 620
Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly
625                 630                 635                 640
Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val
                645                 650                 655
Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala
            660                 665                 670
Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser
        675                 680                 685
Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp
    690                 695                 700
Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala
705                 710                 715                 720
Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp
                725                 730                 735
Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala
            740                 745                 750
Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val
        755                 760                 765
Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe
    770                 775                 780
Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys
785                 790                 795                 800
Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu
                805                 810                 815
Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg
            820                 825                 830
Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro
        835                 840                 845
Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu
    850                 855                 860
Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu
865                 870                 875                 880
Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala
                885                 890                 895
Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe
            900                 905                 910
Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe
        915                 920                 925
Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys
    930                 935                 940
Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His
945                 950                 955                 960
Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys
                965                 970                 975
Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro
            980                 985                 990
Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr Val
        995                 1000                1005
Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn Gln
    1010                1015                1020
Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro Gly
1025                1030                1035                1040
Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln Gly
                1045                1050                1055
Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu Gly
            1060                1065                1070
Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys Gln
        1075                1080                1085
Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr Thr
    1090                1095                1100
Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe Val
1105                1110                1115                1120
Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu Thr
                1125                1130                1135
Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu Arg
            1140                1145                1150
Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly Pro
        1155                1160                1165
Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser Phe
    1170                1175                1180
Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala
1185                1190                1195                1200
Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu
                1205                1210                1215
Trp Gly Leu


<210> 1807
<211> 1400
<212> PRT
<213> Homo sapiens

<400> 1807
Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln
 1               5                  10                  15
Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu
            20                  25                  30
Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys
        35                  40                  45
Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg
    50                  55                  60
Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu
65                  70                  75                  80
Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Ala
                85                  90                  95
Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala
            100                 105                 110
Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn
        115                 120                 125
Thr Ser Tyr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu Gln Leu
    130                 135                 140
Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu Gln Ile
145                 150                 155                 160
His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn
                165                 170                 175
Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu
            180                 185                 190
Asp Ile Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro
        195                 200                 205
Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met
    210                 215                 220
Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile
225                 230                 235                 240
Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val Glu
                245                 250                 255
Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp Leu
            260                 265                 270
Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr Lys
        275                 280                 285
Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser Pro
    290                 295                 300
Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys Met
305                 310                 315                 320
Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro Gly
                325                 330                 335
Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu Phe
            340                 345                 350
Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp Ser
        355                 360                 365
Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe Thr
    370                 375                 380
Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe
385                 390                 395                 400
Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly
                405                 410                 415
Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg
            420                 425                 430
Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys
        435                 440                 445
Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met
    450                 455                 460
His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly
465                 470                 475                 480
Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro Phe
                485                 490                 495
Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile Trp
            500                 505                 510
Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser Ala
        515                 520                 525
Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys Ala
    530                 535                 540
Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe Phe
545                 550                 555                 560
Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala Arg
                565                 570                 575
Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu Pro
            580                 585                 590
Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg
        595                 600                 605
Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys Arg
    610                 615                 620
Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly
625                 630                 635                 640
Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val
                645                 650                 655
Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala
            660                 665                 670
Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser
        675                 680                 685
Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp
    690                 695                 700
Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala
705                 710                 715                 720
Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp
                725                 730                 735
Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala
            740                 745                 750
Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val
        755                 760                 765
Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe
    770                 775                 780
Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys
785                 790                 795                 800
Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu
                805                 810                 815
Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg
            820                 825                 830
Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro
        835                 840                 845
Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu
    850                 855                 860
Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu
865                 870                 875                 880
Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala
                885                 890                 895
Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe
            900                 905                 910
Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe
        915                 920                 925
Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys
    930                 935                 940
Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His
945                 950                 955                 960
Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys
                965                 970                 975
Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro
            980                 985                 990
Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr Val
        995                 1000                1005
Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn Gln
    1010                1015                1020
Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro Gly
1025                1030                1035                1040
Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln Gly
                1045                1050                1055
Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu Gly
            1060                1065                1070
Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys Gln
        1075                1080                1085
Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr Thr
    1090                1095                1100
Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe Val
1105                1110                1115                1120
Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu Thr
                1125                1130                1135
Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu Arg
            1140                1145                1150
Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly Pro
        1155                1160                1165
Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser Phe
    1170                1175                1180
Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala
1185                1190                1195                1200
Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu
                1205                1210                1215
Trp Gly Glu Pro His Gly Arg Asp Ile Ala Gly Gln Gln Ala Thr Gly
            1220                1225                1230
Ala Pro Gly Gly Pro Leu Ser Ala Gly Cys Val Cys Gln Gly Cys Gly
        1235                1240                1245
Ala Glu Asp Val Val Pro Phe Gln Cys Pro Ala Cys Asp Phe Gln Arg
    1250                1255                1260
Cys Gln Ala Cys Trp Gln Arg His Leu Gln Ala Ser Arg Met Cys Pro
1265                1270                1275                1280
Ala Cys His Thr Ala Ser Arg Lys Gln Ser Val Met Gln Val Phe Trp
                1285                1290                1295
Pro Glu Pro His Lys Asp His Glu Gly Ala Gly Gly Ala Arg Pro Val
            1300                1305                1310
Ala Ala Val Pro Gly Val Gly Ala Ala Cys Pro Ala Ala Gly Ala Gly
        1315                1320                1325
Cys Thr Arg Ser Gly Arg Asn Thr His Leu Pro Leu Ala Gly Arg Arg
    1330                1335                1340
Asp Arg Gly Ala Ala Gly Val Cys Pro Val Pro Pro Arg His Leu Cys
1345                1350                1355                1360
Ala Ala Ala Val Pro Pro Arg Gln Pro His Asp Val Trp Pro Val Ser
                1365                1370                1375
Thr Ala Pro Leu His Ala Val Leu Glu Leu Pro Gly Ala Leu Pro Leu
            1380                1385                1390
Leu Gln Arg Pro Leu Arg Gly Ala
        1395                1400

<210> 1808
<211> 1219
<212> PRT
<213> Homo sapiens

<400> 1808
Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln
 1               5                  10                  15
Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu
            20                  25                  30
Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys
        35                  40                  45
Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg
    50                  55                  60
Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu
65                  70                  75                  80
Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Ala
                85                  90                  95
Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala
            100                 105                 110
Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn
        115                 120                 125
Thr Ser Tyr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu Gln Leu
    130                 135                 140
Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu Gln Ile
145                 150                 155                 160
His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn
                165                 170                 175
Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu
            180                 185                 190
Asp Ile Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro
        195                 200                 205
Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met
    210                 215                 220
Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile
225                 230                 235                 240
Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val Glu
                245                 250                 255
Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp Leu
            260                 265                 270
Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr Lys
        275                 280                 285
Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser Pro
    290                 295                 300
Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys Met
305                 310                 315                 320
Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro Gly
                325                 330                 335
Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu Phe
            340                 345                 350
Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp Ser
        355                 360                 365
Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe Thr
    370                 375                 380
Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe
385                 390                 395                 400
Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly
                405                 410                 415
Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg
            420                 425                 430
Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys
        435                 440                 445
Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met
    450                 455                 460
His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly
465                 470                 475                 480
Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro Phe
                485                 490                 495
Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile Trp
            500                 505                 510
Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser Ala
        515                 520                 525
Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys Ala
    530                 535                 540
Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe Phe
545                 550                 555                 560
Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala Arg
                565                 570                 575
Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu Pro
            580                 585                 590
Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg
        595                 600                 605
Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys Arg
    610                 615                 620
Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly
625                 630                 635                 640
Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val
                645                 650                 655
Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala
            660                 665                 670
Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser
        675                 680                 685
Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp
    690                 695                 700
Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala
705                 710                 715                 720
Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp
                725                 730                 735
Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala
            740                 745                 750
Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val
        755                 760                 765
Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe
    770                 775                 780
Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys
785                 790                 795                 800
Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu
                805                 810                 815
Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg
            820                 825                 830
Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro
        835                 840                 845
Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu
    850                 855                 860
Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu
865                 870                 875                 880
Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala
                885                 890                 895
Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe
            900                 905                 910
Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe
        915                 920                 925
Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys
    930                 935                 940
Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His
945                 950                 955                 960
Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys
                965                 970                 975
Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro
            980                 985                 990
Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr Val
        995                 1000                1005
Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn Gln
    1010                1015                1020
Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro Gly
1025                1030                1035                1040
Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln Gly
                1045                1050                1055
Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu Gly
            1060                1065                1070
Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys Gln
        1075                1080                1085
Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr Thr
    1090                1095                1100
Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe Val
1105                1110                1115                1120
Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu Thr
                1125                1130                1135
Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu Arg
            1140                1145                1150
Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly Pro
        1155                1160                1165
Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser Phe
    1170                1175                1180
Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala
1185                1190                1195                1200
Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu
                1205                1210                1215
Trp Gly Leu


<210> 1809
<211> 1400
<212> PRT
<213> Homo sapiens

<400> 1809
Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln
 1               5                  10                  15
Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu
            20                  25                  30
Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys
        35                  40                  45
Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg
    50                  55                  60
Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu
65                  70                  75                  80
Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Ala
                85                  90                  95
Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala
            100                 105                 110
Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn
        115                 120                 125
Thr Ser Tyr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu Gln Leu
    130                 135                 140
Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu Gln Ile
145                 150                 155                 160
His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn
                165                 170                 175
Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu
            180                 185                 190
Asp Ile Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro
        195                 200                 205
Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met
    210                 215                 220
Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile
225                 230                 235                 240
Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val Glu
                245                 250                 255
Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp Leu
            260                 265                 270
Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr Lys
        275                 280                 285
Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser Pro
    290                 295                 300
Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys Met
305                 310                 315                 320
Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro Gly
                325                 330                 335
Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu Phe
            340                 345                 350
Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp Ser
        355                 360                 365
Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe Thr
    370                 375                 380
Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe
385                 390                 395                 400
Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly
                405                 410                 415
Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg
            420                 425                 430
Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys
        435                 440                 445
Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met
    450                 455                 460
His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly
465                 470                 475                 480
Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro Phe
                485                 490                 495
Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile Trp
            500                 505                 510
Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser Ala
        515                 520                 525
Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys Ala
    530                 535                 540
Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe Phe
545                 550                 555                 560
Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala Arg
                565                 570                 575
Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu Pro
            580                 585                 590
Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg
        595                 600                 605
Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys Arg
    610                 615                 620
Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly
625                 630                 635                 640
Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val
                645                 650                 655
Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala
            660                 665                 670
Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser
        675                 680                 685
Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp
    690                 695                 700
Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala
705                 710                 715                 720
Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp
                725                 730                 735
Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala
            740                 745                 750
Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val
        755                 760                 765
Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe
    770                 775                 780
Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys
785                 790                 795                 800
Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu
                805                 810                 815
Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg
            820                 825                 830
Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro
        835                 840                 845
Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu
    850                 855                 860
Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu
865                 870                 875                 880
Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala
                885                 890                 895
Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe
            900                 905                 910
Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe
        915                 920                 925
Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys
    930                 935                 940
Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His
945                 950                 955                 960
Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys
                965                 970                 975
Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro
            980                 985                 990
Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr Val
        995                 1000                1005
Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn Gln
    1010                1015                1020
Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro Gly
1025                1030                1035                1040
Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln Gly
                1045                1050                1055
Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu Gly
            1060                1065                1070
Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys Gln
        1075                1080                1085
Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr Thr
    1090                1095                1100
Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe Val
1105                1110                1115                1120
Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu Thr
                1125                1130                1135
Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu Arg
            1140                1145                1150
Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly Pro
        1155                1160                1165
Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser Phe
    1170                1175                1180
Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala
1185                1190                1195                1200
Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu
                1205                1210                1215
Trp Gly Glu Pro His Gly Arg Asp Ile Ala Gly Gln Gln Ala Thr Gly
            1220                1225                1230
Ala Pro Gly Gly Pro Leu Ser Ala Gly Cys Val Cys Gln Gly Cys Gly
        1235                1240                1245
Ala Glu Asp Val Val Pro Phe Gln Cys Pro Ala Cys Asp Phe Gln Arg
    1250                1255                1260
Cys Gln Ala Cys Trp Gln Arg His Leu Gln Ala Ser Arg Met Cys Pro
1265                1270                1275                1280
Ala Cys His Thr Ala Ser Arg Lys Gln Ser Val Met Gln Val Phe Trp
                1285                1290                1295
Pro Glu Pro His Lys Asp His Glu Gly Ala Gly Gly Ala Arg Pro Val
            1300                1305                1310
Ala Ala Val Pro Gly Val Gly Ala Ala Cys Pro Ala Ala Gly Ala Gly
        1315                1320                1325
Cys Thr Arg Ser Gly Arg Asn Thr His Leu Pro Leu Ala Gly Arg Arg
    1330                1335                1340
Asp Arg Gly Ala Ala Gly Val Cys Pro Val Pro Pro Arg His Leu Cys
1345                1350                1355                1360
Ala Ala Ala Val Pro Pro Arg Gln Pro His Asp Val Trp Pro Val Ser
                1365                1370                1375
Thr Ala Pro Leu His Ala Val Leu Glu Leu Pro Gly Ala Leu Pro Leu
            1380                1385                1390
Leu Gln Arg Pro Leu Arg Gly Ala
        1395                1400

<210> 1810
<211> 1219
<212> PRT
<213> Homo sapiens

<400> 1810
Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln
 1               5                  10                  15
Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu
            20                  25                  30
Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys
        35                  40                  45
Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg
    50                  55                  60
Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu
65                  70                  75                  80
Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Ala
                85                  90                  95
Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala
            100                 105                 110
Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn
        115                 120                 125
Thr Ser Tyr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu Gln Leu
    130                 135                 140
Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu Gln Ile
145                 150                 155                 160
His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn
                165                 170                 175
Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu
            180                 185                 190
Asp Ile Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro
        195                 200                 205
Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met
    210                 215                 220
Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile
225                 230                 235                 240
Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val Glu
                245                 250                 255
Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp Leu
            260                 265                 270
Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr Lys
        275                 280                 285
Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser Pro
    290                 295                 300
Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys Met
305                 310                 315                 320
Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro Gly
                325                 330                 335
Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu Phe
            340                 345                 350
Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp Ser
        355                 360                 365
Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe Thr
    370                 375                 380
Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe
385                 390                 395                 400
Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly
                405                 410                 415
Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg
            420                 425                 430
Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys
        435                 440                 445
Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met
    450                 455                 460
His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly
465                 470                 475                 480
Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro Phe
                485                 490                 495
Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile Trp
            500                 505                 510
Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser Ala
        515                 520                 525
Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys Ala
    530                 535                 540
Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe Phe
545                 550                 555                 560
Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala Arg
                565                 570                 575
Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu Pro
            580                 585                 590
Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg
        595                 600                 605
Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys Arg
    610                 615                 620
Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly
625                 630                 635                 640
Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val
                645                 650                 655
Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala
            660                 665                 670
Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser
        675                 680                 685
Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp
    690                 695                 700
Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala
705                 710                 715                 720
Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp
                725                 730                 735
Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala
            740                 745                 750
Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val
        755                 760                 765
Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe
    770                 775                 780
Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys
785                 790                 795                 800
Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu
                805                 810                 815
Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg
            820                 825                 830
Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro
        835                 840                 845
Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu
    850                 855                 860
Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu
865                 870                 875                 880
Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala
                885                 890                 895
Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe
            900                 905                 910
Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe
        915                 920                 925
Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys
    930                 935                 940
Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His
945                 950                 955                 960
Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys
                965                 970                 975
Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro
            980                 985                 990
Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr Val
        995                 1000                1005
Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn Gln
    1010                1015                1020
Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro Gly
1025                1030                1035                1040
Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln Gly
                1045                1050                1055
Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu Gly
            1060                1065                1070
Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys Gln
        1075                1080                1085
Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr Thr
    1090                1095                1100
Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe Val
1105                1110                1115                1120
Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu Thr
                1125                1130                1135
Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu Arg
            1140                1145                1150
Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly Pro
        1155                1160                1165
Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser Phe
    1170                1175                1180
Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala
1185                1190                1195                1200
Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu
                1205                1210                1215
Trp Gly Leu


<210> 1811
<211> 1060
<212> PRT
<213> Homo sapiens

<400> 1811
Ile Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val
 1               5                  10                  15
Glu Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp
            20                  25                  30
Leu Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr
        35                  40                  45
Lys Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser
    50                  55                  60
Pro Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys
65                  70                  75                  80
Met Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro
                85                  90                  95
Gly Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu
            100                 105                 110
Phe Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp
        115                 120                 125
Ser Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe
    130                 135                 140
Thr Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val
145                 150                 155                 160
Phe Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu
                165                 170                 175
Gly Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His
            180                 185                 190
Arg Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg
        195                 200                 205
Lys Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser
    210                 215                 220
Met His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser
225                 230                 235                 240
Gly Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro
                245                 250                 255
Phe Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile
            260                 265                 270
Trp Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser
        275                 280                 285
Ala Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys
    290                 295                 300
Ala Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe
305                 310                 315                 320
Phe Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala
                325                 330                 335
Arg Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu
            340                 345                 350
Pro Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala
        355                 360                 365
Arg Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys
    370                 375                 380
Arg Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg
385                 390                 395                 400
Gly Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg
                405                 410                 415
Val Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly
            420                 425                 430
Ala Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala
        435                 440                 445
Ser Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln
    450                 455                 460
Asp Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp
465                 470                 475                 480
Ala Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr
                485                 490                 495
Asp Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val
            500                 505                 510
Ala Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser
        515                 520                 525
Val Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe
    530                 535                 540
Phe Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu
545                 550                 555                 560
Lys Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser
                565                 570                 575
Leu Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro
            580                 585                 590
Arg Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser
        595                 600                 605
Pro Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser
    610                 615                 620
Glu Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg
625                 630                 635                 640
Leu Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg
                645                 650                 655
Ala Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn
            660                 665                 670
Phe Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp
        675                 680                 685
Phe Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro
    690                 695                 700
Lys Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His
705                 710                 715                 720
His Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly
                725                 730                 735
Cys Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln
            740                 745                 750
Pro Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr
        755                 760                 765
Val Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn
    770                 775                 780
Gln Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro
785                 790                 795                 800
Gly Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln
                805                 810                 815
Gly Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu
            820                 825                 830
Gly Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys
        835                 840                 845
Gln Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr
    850                 855                 860
Thr Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe
865                 870                 875                 880
Val Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu
                885                 890                 895
Thr Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu
            900                 905                 910
Arg Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly
        915                 920                 925
Pro Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser
    930                 935                 940
Phe Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp
945                 950                 955                 960
Ala Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser
                965                 970                 975
Glu Trp Gly Glu Pro His Gly Arg Asp Ile Ala Gly Gln Gln Ala Thr
            980                 985                 990
Gly Ala Pro Gly Gly Pro Leu Ser Ala Gly Cys Val Cys Gln Gly Cys
        995                 1000                1005
Gly Ala Glu Asp Val Val Pro Phe Gln Cys Pro Ala Cys Asp Phe Gln
    1010                1015                1020
Arg Cys Gln Ala Cys Trp Gln Arg His Leu Gln Ala Ser Arg Met Cys
1025                1030                1035                1040
Pro Ala Cys His Thr Ala Ser Arg Lys Gln Ser Val Met Gln Val Phe
                1045                1050                1055
Trp Pro Glu Pro
            1060

<210> 1812
<211> 1400
<212> PRT
<213> Homo sapiens

<400> 1812
Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln
 1               5                  10                  15
Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu
            20                  25                  30
Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys
        35                  40                  45
Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg
    50                  55                  60
Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu
65                  70                  75                  80
Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Ala
                85                  90                  95
Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala
            100                 105                 110
Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn
        115                 120                 125
Thr Ser Tyr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu Gln Leu
    130                 135                 140
Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu Gln Ile
145                 150                 155                 160
His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn
                165                 170                 175
Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu
            180                 185                 190
Asp Ile Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro
        195                 200                 205
Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met
    210                 215                 220
Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile
225                 230                 235                 240
Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val Glu
                245                 250                 255
Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp Leu
            260                 265                 270
Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr Lys
        275                 280                 285
Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser Pro
    290                 295                 300
Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys Met
305                 310                 315                 320
Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro Gly
                325                 330                 335
Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu Phe
            340                 345                 350
Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp Ser
        355                 360                 365
Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe Thr
    370                 375                 380
Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe
385                 390                 395                 400
Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly
                405                 410                 415
Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg
            420                 425                 430
Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys
        435                 440                 445
Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met
    450                 455                 460
His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly
465                 470                 475                 480
Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro Phe
                485                 490                 495
Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile Trp
            500                 505                 510
Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser Ala
        515                 520                 525
Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys Ala
    530                 535                 540
Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe Phe
545                 550                 555                 560
Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala Arg
                565                 570                 575
Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu Pro
            580                 585                 590
Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg
        595                 600                 605
Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys Arg
    610                 615                 620
Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly
625                 630                 635                 640
Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val
                645                 650                 655
Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala
            660                 665                 670
Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser
        675                 680                 685
Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp
    690                 695                 700
Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala
705                 710                 715                 720
Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp
                725                 730                 735
Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala
            740                 745                 750
Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val
        755                 760                 765
Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe
    770                 775                 780
Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys
785                 790                 795                 800
Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu
                805                 810                 815
Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg
            820                 825                 830
Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro
        835                 840                 845
Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu
    850                 855                 860
Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu
865                 870                 875                 880
Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala
                885                 890                 895
Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe
            900                 905                 910
Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe
        915                 920                 925
Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys
    930                 935                 940
Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His
945                 950                 955                 960
Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys
                965                 970                 975
Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro
            980                 985                 990
Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr Val
        995                 1000                1005
Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn Gln
    1010                1015                1020
Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro Gly
1025                1030                1035                1040
Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln Gly
                1045                1050                1055
Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu Gly
            1060                1065                1070
Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys Gln
        1075                1080                1085
Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr Thr
    1090                1095                1100
Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe Val
1105                1110                1115                1120
Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu Thr
                1125                1130                1135
Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu Arg
            1140                1145                1150
Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly Pro
        1155                1160                1165
Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser Phe
    1170                1175                1180
Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala
1185                1190                1195                1200
Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu
                1205                1210                1215
Trp Gly Glu Pro His Gly Arg Asp Ile Ala Gly Gln Gln Ala Thr Gly
            1220                1225                1230
Ala Pro Gly Gly Pro Leu Ser Ala Gly Cys Val Cys Gln Gly Cys Gly
        1235                1240                1245
Ala Glu Asp Val Val Pro Phe Gln Cys Pro Ala Cys Asp Phe Gln Arg
    1250                1255                1260
Cys Gln Ala Cys Trp Gln Arg His Leu Gln Ala Ser Arg Met Cys Pro
1265                1270                1275                1280
Ala Cys His Thr Ala Ser Arg Lys Gln Ser Val Met Gln Val Phe Trp
                1285                1290                1295
Pro Glu Pro His Lys Asp His Glu Gly Ala Gly Gly Ala Arg Pro Val
            1300                1305                1310
Ala Ala Val Pro Gly Val Gly Ala Ala Cys Pro Ala Ala Gly Ala Gly
        1315                1320                1325
Cys Thr Arg Ser Gly Arg Asn Thr His Leu Pro Leu Ala Gly Arg Arg
    1330                1335                1340
Asp Arg Gly Ala Ala Gly Val Cys Pro Val Pro Pro Arg His Leu Cys
1345                1350                1355                1360
Ala Ala Ala Val Pro Pro Arg Gln Pro His Asp Val Trp Pro Val Ser
                1365                1370                1375
Thr Ala Pro Leu His Ala Val Leu Glu Leu Pro Gly Ala Leu Pro Leu
            1380                1385                1390
Leu Gln Arg Pro Leu Arg Gly Ala
        1395                1400

<210> 1813
<211> 1219
<212> PRT
<213> Homo sapiens

<400> 1813
Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln
 1               5                  10                  15
Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu
            20                  25                  30
Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys
        35                  40                  45
Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg
    50                  55                  60
Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu
65                  70                  75                  80
Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Ala
                85                  90                  95
Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala
            100                 105                 110
Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn
        115                 120                 125
Thr Ser Tyr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu Gln Leu
    130                 135                 140
Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu Gln Ile
145                 150                 155                 160
His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn
                165                 170                 175
Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu
            180                 185                 190
Asp Ile Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro
        195                 200                 205
Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met
    210                 215                 220
Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile
225                 230                 235                 240
Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val Glu
                245                 250                 255
Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp Leu
            260                 265                 270
Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr Lys
        275                 280                 285
Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser Pro
    290                 295                 300
Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys Met
305                 310                 315                 320
Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro Gly
                325                 330                 335
Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu Phe
            340                 345                 350
Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp Ser
        355                 360                 365
Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe Thr
    370                 375                 380
Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe
385                 390                 395                 400
Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly
                405                 410                 415
Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg
            420                 425                 430
Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys
        435                 440                 445
Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met
    450                 455                 460
His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly
465                 470                 475                 480
Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro Phe
                485                 490                 495
Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile Trp
            500                 505                 510
Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser Ala
        515                 520                 525
Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys Ala
    530                 535                 540
Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe Phe
545                 550                 555                 560
Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala Arg
                565                 570                 575
Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu Pro
            580                 585                 590
Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg
        595                 600                 605
Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys Arg
    610                 615                 620
Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly
625                 630                 635                 640
Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val
                645                 650                 655
Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala
            660                 665                 670
Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser
        675                 680                 685
Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp
    690                 695                 700
Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala
705                 710                 715                 720
Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp
                725                 730                 735
Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala
            740                 745                 750
Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val
        755                 760                 765
Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe
    770                 775                 780
Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys
785                 790                 795                 800
Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu
                805                 810                 815
Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg
            820                 825                 830
Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro
        835                 840                 845
Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu
    850                 855                 860
Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu
865                 870                 875                 880
Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala
                885                 890                 895
Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe
            900                 905                 910
Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe
        915                 920                 925
Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys
    930                 935                 940
Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His
945                 950                 955                 960
Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys
                965                 970                 975
Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro
            980                 985                 990
Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr Val
        995                 1000                1005
Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn Gln
    1010                1015                1020
Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro Gly
1025                1030                1035                1040
Ser Gln Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln Gly
                1045                1050                1055
Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu Gly
            1060                1065                1070
Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys Gln
        1075                1080                1085
Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr Thr
    1090                1095                1100
Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe Val
1105                1110                1115                1120
Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu Thr
                1125                1130                1135
Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu Arg
            1140                1145                1150
Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly Pro
        1155                1160                1165
Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser Phe
    1170                1175                1180
Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp Ala
1185                1190                1195                1200
Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser Glu
                1205                1210                1215
Trp Gly Leu


<210> 1814
<211> 1161
<212> PRT
<213> Homo sapiens

<400> 1814
Ile Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val
 1               5                  10                  15
Glu Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp
            20                  25                  30
Leu Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr
        35                  40                  45
Lys Ala Ala His Glu Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser
    50                  55                  60
Pro Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys
65                  70                  75                  80
Met Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro
                85                  90                  95
Gly Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu
            100                 105                 110
Phe Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp
        115                 120                 125
Ser Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe
    130                 135                 140
Thr Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val
145                 150                 155                 160
Phe Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu
                165                 170                 175
Gly Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His
            180                 185                 190
Arg Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg
        195                 200                 205
Lys Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser
    210                 215                 220
Met His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser
225                 230                 235                 240
Gly Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro
                245                 250                 255
Phe Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile
            260                 265                 270
Trp Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser
        275                 280                 285
Ala Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys
    290                 295                 300
Ala Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe
305                 310                 315                 320
Phe Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala
                325                 330                 335
Arg Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu
            340                 345                 350
Pro Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala
        355                 360                 365
Arg Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys
    370                 375                 380
Arg Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg
385                 390                 395                 400
Gly Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg
                405                 410                 415
Val Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly
            420                 425                 430
Ala Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala
        435                 440                 445
Ser Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln
    450                 455                 460
Asp Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp
465                 470                 475                 480
Ala Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr
                485                 490                 495
Asp Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val
            500                 505                 510
Ala Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser
        515                 520                 525
Val Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe
    530                 535                 540
Phe Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu
545                 550                 555                 560
Lys Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser
                565                 570                 575
Leu Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro
            580                 585                 590
Arg Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser
        595                 600                 605
Pro Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser
    610                 615                 620
Glu Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg
625                 630                 635                 640
Leu Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg
                645                 650                 655
Ala Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn
            660                 665                 670
Phe Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp
        675                 680                 685
Phe Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro
    690                 695                 700
Lys Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His
705                 710                 715                 720
His Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly
                725                 730                 735
Cys Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln
            740                 745                 750
Pro Val Leu Asp Pro Thr Gly Arg Thr Ala Pro Asp Pro Lys Leu Thr
        755                 760                 765
Val Ser Thr Ala Ala Ala Gln Gln Leu Asp Pro Gln Glu His Leu Asn
    770                 775                 780
Gln Gly Arg Pro His Leu Ser Pro Arg Pro Pro Pro Thr Gly Asp Pro
785                 790                 795                 800
Gly Ser His Pro Gln Trp Gly Ser Gly Val Pro Arg Ala Gly Lys Gln
                805                 810                 815
Gly Gln His Ala Val Ser Ala Tyr Leu Ala Asp Ala Arg Arg Ala Leu
            820                 825                 830
Gly Ser Ala Gly Cys Ser Gln Leu Leu Ala Ala Leu Thr Ala Tyr Lys
        835                 840                 845
Gln Asp Asp Asp Leu Asp Lys Val Leu Ala Val Leu Ala Ala Leu Thr
    850                 855                 860
Thr Ala Lys Pro Glu Asp Phe Pro Leu Leu His Arg Phe Ser Met Phe
865                 870                 875                 880
Val Arg Pro His His Lys Gln Arg Phe Ser Gln Thr Cys Thr Asp Leu
                885                 890                 895
Thr Gly Arg Pro Tyr Pro Gly Met Glu Pro Pro Gly Pro Gln Glu Glu
            900                 905                 910
Arg Leu Ala Val Pro Pro Val Leu Thr His Arg Ala Pro Gln Pro Gly
        915                 920                 925
Pro Ser Arg Ser Glu Lys Thr Gly Lys Thr Gln Ser Lys Ile Ser Ser
    930                 935                 940
Phe Leu Arg Gln Arg Pro Ala Gly Thr Val Gly Ala Gly Gly Glu Asp
945                 950                 955                 960
Ala Gly Pro Ser Gln Ser Ser Gly Pro Pro His Gly Pro Ala Ala Ser
                965                 970                 975
Glu Trp Gly Glu Pro His Gly Arg Asp Ile Ala Gly Gln Gln Ala Thr
            980                 985                 990
Gly Ala Pro Gly Gly Pro Leu Ser Ala Gly Cys Val Cys Gln Gly Cys
        995                 1000                1005
Gly Ala Glu Asp Val Val Pro Phe Gln Cys Pro Ala Cys Asp Phe Gln
    1010                1015                1020
Arg Cys Gln Ala Cys Trp Gln Arg His Leu Gln Ala Ser Arg Met Cys
1025                1030                1035                1040
Pro Ala Cys His Thr Ala Ser Arg Lys Gln Ser Val Met Gln Val Phe
                1045                1050                1055
Trp Pro Glu Pro His Lys Asp His Glu Gly Ala Gly Gly Ala Arg Pro
            1060                1065                1070
Val Ala Ala Val Pro Gly Val Gly Ala Ala Cys Pro Ala Ala Gly Ala
        1075                1080                1085
Gly Cys Thr Arg Ser Gly Arg Asn Thr His Leu Pro Leu Ala Gly Arg
    1090                1095                1100
Arg Asp Arg Gly Ala Ala Gly Val Arg Pro Val Pro Pro Arg His Leu
1105                1110                1115                1120
Cys Ala Ala Ala Val Pro Pro Arg Gln Pro His Asp Val Trp Pro Val
                1125                1130                1135
Ser Thr Ala Pro Leu His Ala Val Leu Glu Leu Pro Gly Ala Leu Pro
            1140                1145                1150
Leu Leu Gln Arg Pro Leu Arg Gly Ala
        1155                1160

<210> 1815
<211> 606
<212> PRT
<213> Homo sapiens

<400> 1815
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg
 1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val
            20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala
        35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu
    50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro
65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu
                85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys
            100                 105                 110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys
        115                 120                 125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys
    130                 135                 140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp
145                 150                 155                 160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu
                165                 170                 175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys
            180                 185                 190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln
        195                 200                 205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr
    210                 215                 220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser
225                 230                 235                 240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly
                245                 250                 255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser
            260                 265                 270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys
        275                 280                 285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu
    290                 295                 300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser
305                 310                 315                 320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys
                325                 330                 335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys
            340                 345                 350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu
        355                 360                 365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp
    370                 375                 380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg
385                 390                 395                 400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly
                405                 410                 415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser
            420                 425                 430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe
        435                 440                 445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu
    450                 455                 460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met
465                 470                 475                 480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly
                485                 490                 495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile
            500                 505                 510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
        515                 520                 525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg
    530                 535                 540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe
545                 550                 555                 560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys
                565                 570                 575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp
            580                 585                 590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro
        595                 600                 605

<210> 1816
<211> 606
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(606)
<223> Xaa = Any Amino Acid

<400> 1816
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg
 1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val
            20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala
        35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu
    50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro
65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu
                85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys
            100                 105                 110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys
        115                 120                 125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys
    130                 135                 140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp
145                 150                 155                 160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu
                165                 170                 175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys
            180                 185                 190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln
        195                 200                 205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr
    210                 215                 220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser
225                 230                 235                 240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly
                245                 250                 255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser
            260                 265                 270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys
        275                 280                 285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Xaa Ser Gly Tyr Tyr Trp Glu
    290                 295                 300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser
305                 310                 315                 320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys
                325                 330                 335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys
            340                 345                 350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu
        355                 360                 365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp
    370                 375                 380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg
385                 390                 395                 400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly
                405                 410                 415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser
            420                 425                 430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe
        435                 440                 445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu
    450                 455                 460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met
465                 470                 475                 480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly
                485                 490                 495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile
            500                 505                 510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
        515                 520                 525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg
    530                 535                 540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe
545                 550                 555                 560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys
                565                 570                 575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp
            580                 585                 590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro
        595                 600                 605

<210> 1817
<211> 609
<212> PRT
<213> Homo sapiens

<400> 1817
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg
 1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val
            20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala
        35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu
    50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro
65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu
                85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys
            100                 105                 110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys
        115                 120                 125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys
    130                 135                 140
Val Asp Met Ser Thr Asn Arg Gln Gln Pro Ser Arg Phe Tyr His Ser
145                 150                 155                 160
Val Gln Asp Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn
                165                 170                 175
Arg Pro Leu Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr
            180                 185                 190
Gln His Cys Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala
        195                 200                 205
Pro Leu Gln Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val
    210                 215                 220
Ser Thr Thr Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln
225                 230                 235                 240
Ser Phe Ser Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr
                245                 250                 255
Pro Arg Gly Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser
            260                 265                 270
Pro His Ser Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala
        275                 280                 285
Asp Asp Lys Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr
    290                 295                 300
Tyr Trp Glu Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly
305                 310                 315                 320
Thr Gly Ser Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val
                325                 330                 335
Ala Val Lys Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln
            340                 345                 350
Ala Phe Lys Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn
        355                 360                 365
Ile Leu Leu Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile
    370                 375                 380
Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala
385                 390                 395                 400
Asp Thr Arg Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr
                405                 410                 415
Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp
            420                 425                 430
Leu Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile
        435                 440                 445
Gly Asp Phe Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln
    450                 455                 460
Pro Leu Glu Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val
465                 470                 475                 480
Ile Arg Met Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr
                485                 490                 495
Ala Tyr Gly Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr
            500                 505                 510
Ser His Ile Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly
        515                 520                 525
Tyr Leu Ser Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala
    530                 535                 540
Met Arg Arg Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg
545                 550                 555                 560
Pro Leu Phe Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser
                565                 570                 575
Leu Pro Lys Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr
            580                 585                 590
Gln Ala Asp Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val
        595                 600                 605
Pro


<210> 1818
<211> 606
<212> PRT
<213> Homo sapiens

<400> 1818
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg
 1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val
            20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala
        35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu
    50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro
65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu
                85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys
            100                 105                 110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys
        115                 120                 125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys
    130                 135                 140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp
145                 150                 155                 160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu
                165                 170                 175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys
            180                 185                 190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln
        195                 200                 205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr
    210                 215                 220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser
225                 230                 235                 240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly
                245                 250                 255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser
            260                 265                 270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys
        275                 280                 285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu
    290                 295                 300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser
305                 310                 315                 320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys
                325                 330                 335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys
            340                 345                 350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu
        355                 360                 365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp
    370                 375                 380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg
385                 390                 395                 400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly
                405                 410                 415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser
            420                 425                 430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe
        435                 440                 445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu
    450                 455                 460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met
465                 470                 475                 480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly
                485                 490                 495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile
            500                 505                 510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
        515                 520                 525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg
    530                 535                 540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe
545                 550                 555                 560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys
                565                 570                 575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp
            580                 585                 590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro
        595                 600                 605

<210> 1819
<211> 606
<212> PRT
<213> Homo sapiens

<400> 1819
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg
 1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val
            20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala
        35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu
    50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro
65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu
                85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys
            100                 105                 110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys
        115                 120                 125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys
    130                 135                 140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp
145                 150                 155                 160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu
                165                 170                 175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys
            180                 185                 190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln
        195                 200                 205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr
    210                 215                 220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser
225                 230                 235                 240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly
                245                 250                 255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser
            260                 265                 270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys
        275                 280                 285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu
    290                 295                 300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser
305                 310                 315                 320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys
                325                 330                 335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys
            340                 345                 350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu
        355                 360                 365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp
    370                 375                 380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg
385                 390                 395                 400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly
                405                 410                 415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser
            420                 425                 430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe
        435                 440                 445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu
    450                 455                 460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met
465                 470                 475                 480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly
                485                 490                 495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile
            500                 505                 510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
        515                 520                 525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg
    530                 535                 540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe
545                 550                 555                 560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys
                565                 570                 575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp
            580                 585                 590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro
        595                 600                 605

<210> 1820
<211> 606
<212> PRT
<213> Homo sapiens

<400> 1820
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg
 1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val
            20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala
        35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu
    50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro
65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu
                85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys
            100                 105                 110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys
        115                 120                 125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys
    130                 135                 140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp
145                 150                 155                 160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu
                165                 170                 175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys
            180                 185                 190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln
        195                 200                 205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr
    210                 215                 220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser
225                 230                 235                 240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly
                245                 250                 255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser
            260                 265                 270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys
        275                 280                 285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu
    290                 295                 300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser
305                 310                 315                 320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys
                325                 330                 335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys
            340                 345                 350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu
        355                 360                 365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp
    370                 375                 380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg
385                 390                 395                 400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly
                405                 410                 415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser
            420                 425                 430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe
        435                 440                 445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu
    450                 455                 460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met
465                 470                 475                 480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly
                485                 490                 495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile
            500                 505                 510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
        515                 520                 525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg
    530                 535                 540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe
545                 550                 555                 560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys
                565                 570                 575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp
            580                 585                 590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro
        595                 600                 605

<210> 1821
<211> 606
<212> PRT
<213> Homo sapiens

<400> 1821
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg
 1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val
            20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala
        35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu
    50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro
65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu
                85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys
            100                 105                 110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys
        115                 120                 125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys
    130                 135                 140
Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp
145                 150                 155                 160
Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu
                165                 170                 175
Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys
            180                 185                 190
Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln
        195                 200                 205
Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr
    210                 215                 220
Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser
225                 230                 235                 240
Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly
                245                 250                 255
Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser
            260                 265                 270
Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys
        275                 280                 285
Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu
    290                 295                 300
Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser
305                 310                 315                 320
Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys
                325                 330                 335
Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys
            340                 345                 350
Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu
        355                 360                 365
Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp
    370                 375                 380
Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg
385                 390                 395                 400
Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly
                405                 410                 415
Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser
            420                 425                 430
Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe
        435                 440                 445
Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu
    450                 455                 460
Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met
465                 470                 475                 480
Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly
                485                 490                 495
Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile
            500                 505                 510
Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
        515                 520                 525
Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg
    530                 535                 540
Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe
545                 550                 555                 560
Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys
                565                 570                 575
Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp
            580                 585                 590
Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro
        595                 600                 605

<210> 1822
<211> 609
<212> PRT
<213> Homo sapiens

<400> 1822
Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg
 1               5                  10                  15
Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val
            20                  25                  30
Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala
        35                  40                  45
Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu
    50                  55                  60
Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro
65                  70                  75                  80
Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu
                85                  90                  95
Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys
            100                 105                 110
Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys
        115                 120                 125
Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys
    130                 135                 140
Val Asp Met Ser Thr Asn Arg Gln Gln Pro Ser Arg Phe Tyr His Ser
145                 150                 155                 160
Val Gln Asp Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn
                165                 170                 175
Arg Pro Leu Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr
            180                 185                 190
Gln His Cys Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala
        195                 200                 205
Pro Leu Gln Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val
    210                 215                 220
Ser Thr Thr Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln
225                 230                 235                 240
Ser Phe Ser Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr
                245                 250                 255
Pro Arg Gly Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser
            260                 265                 270
Pro His Ser Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala
        275                 280                 285
Asp Asp Lys Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr
    290                 295                 300
Tyr Trp Glu Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly
305                 310                 315                 320
Thr Gly Ser Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val
                325                 330                 335
Ala Val Lys Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln
            340                 345                 350
Ala Phe Lys Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn
        355                 360                 365
Ile Leu Leu Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile
    370                 375                 380
Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala
385                 390                 395                 400
Asp Thr Arg Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr
                405                 410                 415
Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp
            420                 425                 430
Leu Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile
        435                 440                 445
Gly Asp Phe Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln
    450                 455                 460
Pro Leu Glu Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val
465                 470                 475                 480
Ile Arg Met Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr
                485                 490                 495
Ala Tyr Gly Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr
            500                 505                 510
Ser His Ile Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly
        515                 520                 525
Tyr Leu Ser Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala
    530                 535                 540
Met Arg Arg Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg
545                 550                 555                 560
Pro Leu Phe Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser
                565                 570                 575
Leu Pro Lys Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr
            580                 585                 590
Gln Ala Asp Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val
        595                 600                 605
Pro


<210> 1823
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1823
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu
                165                 170                 175
Ile Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1824
<211> 396
<212> PRT
<213> Homo sapiens

<400> 1824
Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp Asp
 1               5                  10                  15
Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln Leu
            20                  25                  30
Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu Asp
        35                  40                  45
Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met Leu
    50                  55                  60
Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu Asp
65                  70                  75                  80
Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr Ser
                85                  90                  95
Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala Thr
            100                 105                 110
Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu Ile
        115                 120                 125
Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu Lys
    130                 135                 140
Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu Gln
145                 150                 155                 160
Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn His
                165                 170                 175
Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro Gln
            180                 185                 190
Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr Leu
        195                 200                 205
Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln Val
    210                 215                 220
Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr Lys
225                 230                 235                 240
Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp Phe
                245                 250                 255
Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val Asn
            260                 265                 270
Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala Arg
        275                 280                 285
Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser Ile
    290                 295                 300
Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu Arg
305                 310                 315                 320
Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile Asp
                325                 330                 335
Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro Tyr
            340                 345                 350
Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln Met
        355                 360                 365
Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser Glu
    370                 375                 380
Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
385                 390                 395

<210> 1825
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1825
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu
                165                 170                 175
Ile Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1826
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1826
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu
                165                 170                 175
Ile Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1827
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1827
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu
                165                 170                 175
Ile Leu Met Gln Asn Trp Asp Ala Val Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1828
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1828
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu
                165                 170                 175
Ile Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1829
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1829
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu
                165                 170                 175
Ile Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1830
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1830
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu
                165                 170                 175
Ile Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1831
<211> 445
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(445)
<223> Xaa = Any Amino Acid

<400> 1831
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Xaa Gly Lys Leu Asp Xaa Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Xaa Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Xaa Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Xaa
                165                 170                 175
Xaa Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Xaa Cys Xaa Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Xaa Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1832
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1832
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu
                165                 170                 175
Ile Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1833
<211> 396
<212> PRT
<213> Homo sapiens

<400> 1833
Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp Asp
 1               5                  10                  15
Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln Leu
            20                  25                  30
Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu Asp
        35                  40                  45
Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met Leu
    50                  55                  60
Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu Asp
65                  70                  75                  80
Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr Ser
                85                  90                  95
Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala Thr
            100                 105                 110
Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu Ile
        115                 120                 125
Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu Lys
    130                 135                 140
Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu Gln
145                 150                 155                 160
Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn His
                165                 170                 175
Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro Gln
            180                 185                 190
Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr Leu
        195                 200                 205
Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln Val
    210                 215                 220
Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr Lys
225                 230                 235                 240
Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp Phe
                245                 250                 255
Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val Asn
            260                 265                 270
Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala Arg
        275                 280                 285
Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser Ile
    290                 295                 300
Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu Arg
305                 310                 315                 320
Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile Asp
                325                 330                 335
Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro Tyr
            340                 345                 350
Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln Met
        355                 360                 365
Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser Glu
    370                 375                 380
Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
385                 390                 395

<210> 1834
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1834
Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg
 1               5                  10                  15
His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr
            20                  25                  30
Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr
        35                  40                  45
Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp
    50                  55                  60
Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln
65                  70                  75                  80
Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu
                85                  90                  95
Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met
            100                 105                 110
Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu
        115                 120                 125
Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr
    130                 135                 140
Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala
145                 150                 155                 160
Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu
                165                 170                 175
Ile Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu
            180                 185                 190
Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu
        195                 200                 205
Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn
    210                 215                 220
His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro
225                 230                 235                 240
Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr
                245                 250                 255
Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln
            260                 265                 270
Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr
        275                 280                 285
Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp
    290                 295                 300
Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val
305                 310                 315                 320
Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala
                325                 330                 335
Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser
            340                 345                 350
Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu
        355                 360                 365
Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile
    370                 375                 380
Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro
385                 390                 395                 400
Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln
                405                 410                 415
Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser
            420                 425                 430
Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
        435                 440                 445

<210> 1835
<211> 396
<212> PRT
<213> Homo sapiens

<400> 1835
Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp Asp
 1               5                  10                  15
Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln Leu
            20                  25                  30
Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu Asp
        35                  40                  45
Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met Leu
    50                  55                  60
Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu Asp
65                  70                  75                  80
Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr Ser
                85                  90                  95
Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala Thr
            100                 105                 110
Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu Ile
        115                 120                 125
Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu Lys
    130                 135                 140
Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu Gln
145                 150                 155                 160
Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn His
                165                 170                 175
Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro Gln
            180                 185                 190
Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr Leu
        195                 200                 205
Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln Val
    210                 215                 220
Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr Lys
225                 230                 235                 240
Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp Phe
                245                 250                 255
Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val Asn
            260                 265                 270
Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala Arg
        275                 280                 285
Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser Ile
    290                 295                 300
Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu Arg
305                 310                 315                 320
Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile Asp
                325                 330                 335
Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro Tyr
            340                 345                 350
Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln Met
        355                 360                 365
Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser Glu
    370                 375                 380
Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
385                 390                 395

<210> 1836
<211> 510
<212> PRT
<213> Homo sapiens

<400> 1836
Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys
 1               5                  10                  15
Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg
            20                  25                  30
Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln
        35                  40                  45
Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro
    50                  55                  60
Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu
65                  70                  75                  80
His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser
                85                  90                  95
Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr
            100                 105                 110
Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro
        115                 120                 125
Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr
    130                 135                 140
His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser
145                 150                 155                 160
Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro
                165                 170                 175
Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala
            180                 185                 190
Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro
        195                 200                 205
Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu
    210                 215                 220
Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg
225                 230                 235                 240
Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro
                245                 250                 255
Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu
            260                 265                 270
His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser
        275                 280                 285
Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu
    290                 295                 300
Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser
305                 310                 315                 320
Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp
                325                 330                 335
Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu
            340                 345                 350
Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu
        355                 360                 365
Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala
    370                 375                 380
His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu
385                 390                 395                 400
Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala
                405                 410                 415
Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys
            420                 425                 430
Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val
        435                 440                 445
Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg
    450                 455                 460
Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr
465                 470                 475                 480
Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met
                485                 490                 495
Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr
            500                 505                 510

<210> 1837
<211> 510
<212> PRT
<213> Homo sapiens

<400> 1837
Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys
 1               5                  10                  15
Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg
            20                  25                  30
Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln
        35                  40                  45
Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro
    50                  55                  60
Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu
65                  70                  75                  80
His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser
                85                  90                  95
Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr
            100                 105                 110
Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro
        115                 120                 125
Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr
    130                 135                 140
His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser
145                 150                 155                 160
Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro
                165                 170                 175
Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala
            180                 185                 190
Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro
        195                 200                 205
Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu
    210                 215                 220
Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg
225                 230                 235                 240
Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro
                245                 250                 255
Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu
            260                 265                 270
His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser
        275                 280                 285
Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu
    290                 295                 300
Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser
305                 310                 315                 320
Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp
                325                 330                 335
Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu
            340                 345                 350
Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu
        355                 360                 365
Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala
    370                 375                 380
His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu
385                 390                 395                 400
Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala
                405                 410                 415
Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys
            420                 425                 430
Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val
        435                 440                 445
Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg
    450                 455                 460
Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr
465                 470                 475                 480
Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met
                485                 490                 495
Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr
            500                 505                 510

<210> 1838
<211> 510
<212> PRT
<213> Homo sapiens

<400> 1838
Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys
 1               5                  10                  15
Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg
            20                  25                  30
Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln
        35                  40                  45
Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro
    50                  55                  60
Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu
65                  70                  75                  80
His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser
                85                  90                  95
Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr
            100                 105                 110
Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro
        115                 120                 125
Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr
    130                 135                 140
His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser
145                 150                 155                 160
Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro
                165                 170                 175
Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala
            180                 185                 190
Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro
        195                 200                 205
Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu
    210                 215                 220
Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg
225                 230                 235                 240
Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro
                245                 250                 255
Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu
            260                 265                 270
His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser
        275                 280                 285
Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu
    290                 295                 300
Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser
305                 310                 315                 320
Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp
                325                 330                 335
Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu
            340                 345                 350
Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu
        355                 360                 365
Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala
    370                 375                 380
His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu
385                 390                 395                 400
Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala
                405                 410                 415
Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys
            420                 425                 430
Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val
        435                 440                 445
Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg
    450                 455                 460
Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr
465                 470                 475                 480
Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met
                485                 490                 495
Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr
            500                 505                 510

<210> 1839
<211> 203
<212> PRT
<213> Homo sapiens

<400> 1839
Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser Ser His Glu Gly Phe
 1               5                  10                  15
Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp Asp Thr Cys Val Val
            20                  25                  30
Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu Pro Thr Met Tyr Arg
        35                  40                  45
Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu Gln Leu Trp Gln Phe
    50                  55                  60
Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala His Phe Ile Ala Trp
65                  70                  75                  80
Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu Pro Glu Glu Val Ala
                85                  90                  95
Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala Met Asn Tyr Asp Lys
            100                 105                 110
Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys Gly Ile Met Gln Lys
        115                 120                 125
Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val Cys Asp Pro Asp Ala
    130                 135                 140
Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg Pro Phe Leu Lys Ala
145                 150                 155                 160
Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr Leu Pro Leu Thr His
                165                 170                 175
Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met Asp Arg Cys Ser Ser
            180                 185                 190
Leu Pro Tyr Ala Glu Val Cys Leu Leu Ser Phe
        195                 200

<210> 1840
<211> 520
<212> PRT
<213> Homo sapiens

<400> 1840
Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys
 1               5                  10                  15
Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg
            20                  25                  30
Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln
        35                  40                  45
Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro
    50                  55                  60
Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu
65                  70                  75                  80
His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser
                85                  90                  95
Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Phe Gly Ala Asn Tyr
            100                 105                 110
Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro
        115                 120                 125
Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr
    130                 135                 140
His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser
145                 150                 155                 160
Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro
                165                 170                 175
Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala
            180                 185                 190
Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro
        195                 200                 205
Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu
    210                 215                 220
Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg
225                 230                 235                 240
Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro
                245                 250                 255
Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu
            260                 265                 270
His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser
        275                 280                 285
Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu
    290                 295                 300
Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser
305                 310                 315                 320
Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp
                325                 330                 335
Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu
            340                 345                 350
Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu
        355                 360                 365
Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala
    370                 375                 380
His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu
385                 390                 395                 400
Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala
                405                 410                 415
Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys
            420                 425                 430
Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val
        435                 440                 445
Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg
    450                 455                 460
Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr
465                 470                 475                 480
Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met
                485                 490                 495
Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Val Leu Leu Thr Lys Phe
            500                 505                 510
Leu Ser Gly Gly Val Ala Lys Pro
        515                 520

<210> 1841
<211> 510
<212> PRT
<213> Homo sapiens

<400> 1841
Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys
 1               5                  10                  15
Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg
            20                  25                  30
Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln
        35                  40                  45
Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro
    50                  55                  60
Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu
65                  70                  75                  80
His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser
                85                  90                  95
Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr
            100                 105                 110
Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro
        115                 120                 125
Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr
    130                 135                 140
His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser
145                 150                 155                 160
Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro
                165                 170                 175
Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala
            180                 185                 190
Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro
        195                 200                 205
Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu
    210                 215                 220
Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg
225                 230                 235                 240
Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro
                245                 250                 255
Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu
            260                 265                 270
His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser
        275                 280                 285
Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu
    290                 295                 300
Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser
305                 310                 315                 320
Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp
                325                 330                 335
Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu
            340                 345                 350
Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu
        355                 360                 365
Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala
    370                 375                 380
His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu
385                 390                 395                 400
Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala
                405                 410                 415
Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys
            420                 425                 430
Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val
        435                 440                 445
Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg
    450                 455                 460
Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr
465                 470                 475                 480
Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met
                485                 490                 495
Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr
            500                 505                 510

<210> 1842
<211> 510
<212> PRT
<213> Homo sapiens

<400> 1842
Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys
 1               5                  10                  15
Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg
            20                  25                  30
Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln
        35                  40                  45
Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro
    50                  55                  60
Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu
65                  70                  75                  80
His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser
                85                  90                  95
Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr
            100                 105                 110
Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro
        115                 120                 125
Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr
    130                 135                 140
His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser
145                 150                 155                 160
Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro
                165                 170                 175
Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala
            180                 185                 190
Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro
        195                 200                 205
Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu
    210                 215                 220
Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg
225                 230                 235                 240
Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro
                245                 250                 255
Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu
            260                 265                 270
His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser
        275                 280                 285
Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu
    290                 295                 300
Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser
305                 310                 315                 320
Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp
                325                 330                 335
Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu
            340                 345                 350
Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu
        355                 360                 365
Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala
    370                 375                 380
His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu
385                 390                 395                 400
Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala
                405                 410                 415
Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys
            420                 425                 430
Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val
        435                 440                 445
Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg
    450                 455                 460
Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr
465                 470                 475                 480
Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met
                485                 490                 495
Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr
            500                 505                 510

<210> 1843
<211> 1354
<212> PRT
<213> Homo sapiens

<400> 1843
Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn
 1               5                  10                  15
Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp
            20                  25                  30
Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys
        35                  40                  45
Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn
    50                  55                  60
Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys
65                  70                  75                  80
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
                85                  90                  95
Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
            100                 105                 110
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
        115                 120                 125
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
    130                 135                 140
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
145                 150                 155                 160
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg
                165                 170                 175
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
            180                 185                 190
Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
        195                 200                 205
Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn
    210                 215                 220
Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
225                 230                 235                 240
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly
                245                 250                 255
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
            260                 265                 270
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
        275                 280                 285
Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp
    290                 295                 300
Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
305                 310                 315                 320
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu
                325                 330                 335
Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val
            340                 345                 350
Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe
        355                 360                 365
Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro
    370                 375                 380
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr
385                 390                 395                 400
Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr
                405                 410                 415
Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile
            420                 425                 430
Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu
        435                 440                 445
Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met
    450                 455                 460
Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr
465                 470                 475                 480
Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn
                485                 490                 495
Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val
            500                 505                 510
Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys
        515                 520                 525
Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln
    530                 535                 540
Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr
545                 550                 555                 560
Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser
                565                 570                 575
Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu
            580                 585                 590
Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala
        595                 600                 605
Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile
    610                 615                 620
Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His
625                 630                 635                 640
Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln
                645                 650                 655
Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp
            660                 665                 670
Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val
        675                 680                 685
Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser
    690                 695                 700
Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu
705                 710                 715                 720
Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln
                725                 730                 735
Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln
            740                 745                 750
Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu
        755                 760                 765
Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu
    770                 775                 780
Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu
785                 790                 795                 800
Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu
                805                 810                 815
Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr
            820                 825                 830
Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala
        835                 840                 845
Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys
    850                 855                 860
Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu
865                 870                 875                 880
Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu
                885                 890                 895
Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln
            900                 905                 910
Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg
        915                 920                 925
Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala
    930                 935                 940
Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu
945                 950                 955                 960
Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu
                965                 970                 975
Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile
            980                 985                 990
Asn Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
        995                 1000                1005
Ile Met Asn Arg Lys Asp Phe Lys Ile Asp Arg Lys Lys Ala Asn Thr
    1010                1015                1020
Gln Asp Leu Arg Lys Lys Glu Lys Glu Asn Arg Lys Leu Gln Leu Glu
1025                1030                1035                1040
Leu Asn Gln Glu Arg Glu Lys Phe Asn Gln Met Val Val Lys His Gln
                1045                1050                1055
Lys Glu Leu Asn Asp Met Gln Ala Gln Leu Val Glu Glu Cys Ala His
            1060                1065                1070
Arg Asn Glu Leu Gln Met Gln Leu Ala Ser Lys Glu Ser Asp Ile Glu
        1075                1080                1085
Gln Leu Arg Ala Lys Leu Leu Asp Leu Ser Asp Ser Thr Ser Val Ala
    1090                1095                1100
Ser Phe Pro Ser Ala Asp Glu Thr Asp Gly Asn Leu Pro Glu Ser Arg
1105                1110                1115                1120
Ile Glu Gly Trp Leu Ser Val Pro Asn Arg Gly Asn Ile Lys Arg Tyr
                1125                1130                1135
Gly Trp Lys Lys Gln Tyr Val Val Val Ser Ser Lys Lys Ile Leu Phe
            1140                1145                1150
Tyr Asn Asp Glu Gln Asp Lys Glu Gln Ser Asn Pro Ser Met Val Leu
        1155                1160                1165
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Gly Asp Val
    1170                1175                1180
Tyr Arg Ala Glu Thr Glu Glu Ile Pro Lys Ile Phe Gln Ile Leu Tyr
1185                1190                1195                1200
Ala Asn Glu Gly Glu Cys Arg Lys Asp Val Glu Met Glu Pro Val Gln
                1205                1210                1215
Gln Ala Glu Lys Thr Asn Phe Gln Asn His Lys Gly His Glu Phe Ile
            1220                1225                1230
Pro Thr Leu Tyr His Phe Pro Ala Asn Cys Asp Ala Cys Ala Lys Pro
        1235                1240                1245
Leu Trp His Val Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
    1250                1255                1260
His Val Lys Cys His Arg Asp His Leu Asp Lys Lys Glu Asp Leu Ile
1265                1270                1275                1280
Cys Pro Cys Lys Val Ser Tyr Asp Val Thr Ser Ala Arg Asp Met Leu
                1285                1290                1295
Leu Leu Ala Cys Ser Gln Asp Glu Gln Lys Lys Trp Val Thr His Leu
            1300                1305                1310
Val Lys Lys Ile Pro Lys Asn Pro Pro Ser Gly Phe Val Arg Ala Ser
        1315                1320                1325
Pro Arg Thr Leu Ser Thr Arg Ser Thr Ala Asn Gln Ser Phe Arg Lys
    1330                1335                1340
Val Val Lys Asn Thr Ser Gly Lys Thr Ser
1345                1350

<210> 1844
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 1844
Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr
 1               5                  10                  15
Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala
            20                  25                  30
Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp
        35                  40                  45
Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys
    50                  55                  60
Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys
65                  70                  75                  80
Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys
                85                  90                  95
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
            100                 105                 110
Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
        115                 120                 125
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
    130                 135                 140
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
145                 150                 155                 160
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
                165                 170                 175
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys
            180                 185                 190
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
        195                 200                 205
Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
    210                 215                 220
His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp
225                 230                 235                 240
Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
                245                 250                 255
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly
            260                 265                 270
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
        275                 280                 285
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
    290                 295                 300
Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu
305                 310                 315                 320
Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
                325                 330                 335
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro
            340                 345                 350
Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala
        355                 360                 365
Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe
    370                 375                 380
Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro
385                 390                 395                 400
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr
                405                 410                 415
Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Asn Asp
            420                 425                 430
Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys
        435                 440                 445
Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu
    450                 455                 460
Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr
465                 470                 475                 480
Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser
                485                 490                 495
Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn
            500                 505                 510
Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn
        515                 520                 525
Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys
    530                 535                 540
Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu
545                 550                 555                 560
Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp
                565                 570                 575
Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile
            580                 585                 590
Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu
        595                 600                 605
Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln
    610                 615                 620
Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile
625                 630                 635                 640
Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys
                645                 650                 655
Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu
            660                 665                 670
Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile
        675                 680                 685
Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu
    690                 695                 700
Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys
705                 710                 715                 720
Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met
                725                 730                 735
Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn
            740                 745                 750
Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu
        755                 760                 765
Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val
    770                 775                 780
Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr
785                 790                 795                 800
Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln
                805                 810                 815
Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn
            820                 825                 830
His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu
        835                 840                 845
Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp
    850                 855                 860
Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val
865                 870                 875                 880
Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu
                885                 890                 895
Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala
            900                 905                 910
Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala
        915                 920                 925
Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile
    930                 935                 940
Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu
945                 950                 955                 960
Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg
                965                 970                 975
Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu
            980                 985                 990
Asn Asn Lys Leu Lys Asp Val Gln Glu Gln Leu Ser Arg Leu Lys Asp
        995                 1000                1005
Glu Glu Ile Ser Ala Ala Ala Ile Lys Ala Gln Phe Glu Lys Gln Leu
    1010                1015                1020
Leu Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
1025                1030                1035                1040
Ile Met Asn Arg Lys Glu Pro Val Lys Arg Gly Asn Asp Thr Asp Val
                1045                1050                1055
Arg Arg Lys Glu Lys Glu Asn Arg Lys Leu His Met Glu Leu Lys Ser
            1060                1065                1070
Glu Arg Glu Lys Leu Thr Gln Gln Met Ile Lys Tyr Gln Lys Glu Leu
        1075                1080                1085
Asn Glu Met Gln Ala Gln Ile Ala Glu Glu Ser Gln Ile Arg Ile Glu
    1090                1095                1100
Leu Gln Met Thr Leu Asp Ser Lys Asp Ser Asp Ile Glu Gln Leu Arg
1105                1110                1115                1120
Ser Gln Leu Gln Ala Leu His Ile Gly Leu Asp Ser Ser Ser Ile Gly
                1125                1130                1135
Ser Gly Pro Gly Asp Ala Glu Ala Asp Asp Gly Phe Pro Glu Ser Arg
            1140                1145                1150
Leu Glu Gly Trp Leu Ser Leu Pro Val Arg Asn Asn Thr Lys Lys Phe
        1155                1160                1165
Gly Trp Val Lys Lys Tyr Val Ile Val Ser Ser Lys Lys Ile Leu Phe
    1170                1175                1180
Tyr Asp Ser Glu Gln Asp Lys Glu Gln Ser Asn Pro Tyr Met Val Leu
1185                1190                1195                1200
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Thr Asp Val
                1205                1210                1215
Tyr Arg Ala Asp Ala Lys Glu Ile Pro Arg Ile Phe Gln Ile Leu Tyr
            1220                1225                1230
Ala Asn Glu Gly Glu Ser Lys Lys Glu Gln Glu Phe Pro Val Glu Pro
        1235                1240                1245
Val Gly Glu Lys Ser Asn Tyr Ile Cys His Lys Gly His Glu Phe Ile
    1250                1255                1260
Pro Thr Leu Tyr His Phe Pro Thr Asn Cys Glu Ala Cys Met Lys Pro
1265                1270                1275                1280
Leu Trp His Met Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
                1285                1290                1295
His Ile Lys Cys His Lys Asp His Met Asp Lys Lys Glu Glu Ile Ile
            1300                1305                1310
Ala Pro Cys Lys Val Tyr Tyr Asp Ile Ser Thr Ala Lys Asn Leu Leu
        1315                1320                1325
Leu Leu Ala Asn Ser Thr Glu Glu Gln Gln Lys Trp Val Ser Arg Leu
    1330                1335                1340
Val Lys Lys Ile Pro Lys Lys Pro Pro Ala Pro Asp Pro Phe Ala Arg
1345                1350                1355                1360
Ser Ser Pro Arg Thr Ser Met Lys Ile Gln Gln Asn Gln Ser Ile Arg
                1365                1370                1375
Arg Pro Ser Arg Gln Leu Ala Pro Asn Lys Pro Ser
            1380                1385

<210> 1845
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 1845
Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr
 1               5                  10                  15
Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala
            20                  25                  30
Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp
        35                  40                  45
Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys
    50                  55                  60
Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys
65                  70                  75                  80
Lys Ile Lys Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys
                85                  90                  95
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
            100                 105                 110
Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
        115                 120                 125
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
    130                 135                 140
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
145                 150                 155                 160
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
                165                 170                 175
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys
            180                 185                 190
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
        195                 200                 205
Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
    210                 215                 220
His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp
225                 230                 235                 240
Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
                245                 250                 255
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly
            260                 265                 270
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
        275                 280                 285
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
    290                 295                 300
Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu
305                 310                 315                 320
Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
                325                 330                 335
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro
            340                 345                 350
Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala
        355                 360                 365
Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe
    370                 375                 380
Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro
385                 390                 395                 400
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr
                405                 410                 415
Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Asn Asp
            420                 425                 430
Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys
        435                 440                 445
Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu
    450                 455                 460
Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr
465                 470                 475                 480
Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser
                485                 490                 495
Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn
            500                 505                 510
Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn
        515                 520                 525
Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys
    530                 535                 540
Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu
545                 550                 555                 560
Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp
                565                 570                 575
Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile
            580                 585                 590
Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu
        595                 600                 605
Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln
    610                 615                 620
Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile
625                 630                 635                 640
Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys
                645                 650                 655
Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu
            660                 665                 670
Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile
        675                 680                 685
Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu
    690                 695                 700
Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys
705                 710                 715                 720
Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met
                725                 730                 735
Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn
            740                 745                 750
Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu
        755                 760                 765
Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val
    770                 775                 780
Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr
785                 790                 795                 800
Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln
                805                 810                 815
Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn
            820                 825                 830
His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu
        835                 840                 845
Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp
    850                 855                 860
Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val
865                 870                 875                 880
Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu
                885                 890                 895
Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala
            900                 905                 910
Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala
        915                 920                 925
Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile
    930                 935                 940
Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu
945                 950                 955                 960
Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg
                965                 970                 975
Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu
            980                 985                 990
Asn Asn Lys Leu Lys Asp Val Gln Glu Gln Leu Ser Arg Leu Lys Asp
        995                 1000                1005
Glu Glu Ile Ser Ala Ala Ala Ile Lys Ala Gln Phe Glu Lys Gln Leu
    1010                1015                1020
Leu Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
1025                1030                1035                1040
Ile Met Asn Arg Lys Glu Pro Val Lys Arg Gly Asn Asp Thr Asp Val
                1045                1050                1055
Arg Arg Lys Glu Lys Glu Asn Arg Lys Leu His Met Glu Leu Lys Ser
            1060                1065                1070
Glu Arg Glu Lys Leu Thr Gln Gln Met Ile Lys Tyr Gln Lys Glu Leu
        1075                1080                1085
Asn Glu Met Gln Ala Gln Ile Ala Glu Glu Ser Gln Ile Arg Ile Glu
    1090                1095                1100
Leu Gln Met Thr Leu Asp Ser Lys Asp Ser Asp Ile Glu Gln Leu Arg
1105                1110                1115                1120
Ser Gln Leu Gln Ala Leu His Ile Gly Leu Asp Ser Ser Ser Ile Gly
                1125                1130                1135
Ser Gly Pro Gly Asp Ala Glu Ala Asp Asp Gly Phe Pro Glu Ser Arg
            1140                1145                1150
Leu Glu Gly Trp Leu Ser Leu Pro Val Arg Asn Asn Thr Lys Lys Phe
        1155                1160                1165
Gly Trp Val Lys Lys Tyr Val Ile Val Ser Ser Lys Lys Ile Leu Phe
    1170                1175                1180
Tyr Asp Ser Glu Gln Asp Lys Glu Gln Ser Asn Pro Tyr Met Val Leu
1185                1190                1195                1200
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Thr Asp Val
                1205                1210                1215
Tyr Arg Ala Asp Ala Lys Glu Ile Pro Arg Ile Phe Gln Ile Leu Tyr
            1220                1225                1230
Ala Asn Glu Gly Glu Ser Lys Lys Glu Gln Glu Phe Pro Val Glu Pro
        1235                1240                1245
Val Gly Glu Lys Ser Asn Tyr Ile Cys His Lys Gly His Glu Phe Ile
    1250                1255                1260
Pro Thr Leu Tyr His Phe Pro Thr Asn Cys Glu Ala Cys Met Lys Pro
1265                1270                1275                1280
Leu Trp His Met Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
                1285                1290                1295
His Ile Lys Cys His Lys Asp His Met Asp Lys Lys Glu Glu Ile Ile
            1300                1305                1310
Ala Pro Cys Lys Val Tyr Tyr Asp Ile Ser Thr Ala Lys Asn Leu Leu
        1315                1320                1325
Leu Leu Ala Asn Ser Thr Glu Glu Gln Gln Lys Trp Val Ser Arg Leu
    1330                1335                1340
Val Lys Lys Ile Pro Lys Lys Pro Pro Ala Pro Asp Pro Phe Ala Arg
1345                1350                1355                1360
Ser Ser Pro Arg Thr Ser Met Lys Ile Gln Gln Asn Gln Ser Ile Arg
                1365                1370                1375
Arg Pro Ser Arg Gln Leu Ala Pro Asn Lys Pro Ser
            1380                1385

<210> 1846
<211> 1354
<212> PRT
<213> Homo sapiens

<400> 1846
Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn
 1               5                  10                  15
Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp
            20                  25                  30
Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys
        35                  40                  45
Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn
    50                  55                  60
Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys
65                  70                  75                  80
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
                85                  90                  95
Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
            100                 105                 110
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
        115                 120                 125
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
    130                 135                 140
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
145                 150                 155                 160
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg
                165                 170                 175
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
            180                 185                 190
Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
        195                 200                 205
Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn
    210                 215                 220
Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
225                 230                 235                 240
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly
                245                 250                 255
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
            260                 265                 270
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
        275                 280                 285
Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp
    290                 295                 300
Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
305                 310                 315                 320
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu
                325                 330                 335
Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val
            340                 345                 350
Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe
        355                 360                 365
Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro
    370                 375                 380
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr
385                 390                 395                 400
Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr
                405                 410                 415
Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile
            420                 425                 430
Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu
        435                 440                 445
Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met
    450                 455                 460
Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr
465                 470                 475                 480
Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn
                485                 490                 495
Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val
            500                 505                 510
Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys
        515                 520                 525
Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln
    530                 535                 540
Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr
545                 550                 555                 560
Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser
                565                 570                 575
Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu
            580                 585                 590
Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala
        595                 600                 605
Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile
    610                 615                 620
Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His
625                 630                 635                 640
Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln
                645                 650                 655
Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp
            660                 665                 670
Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val
        675                 680                 685
Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser
    690                 695                 700
Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu
705                 710                 715                 720
Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln
                725                 730                 735
Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln
            740                 745                 750
Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu
        755                 760                 765
Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu
    770                 775                 780
Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu
785                 790                 795                 800
Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu
                805                 810                 815
Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr
            820                 825                 830
Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala
        835                 840                 845
Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys
    850                 855                 860
Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu
865                 870                 875                 880
Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu
                885                 890                 895
Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln
            900                 905                 910
Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg
        915                 920                 925
Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala
    930                 935                 940
Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu
945                 950                 955                 960
Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu
                965                 970                 975
Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile
            980                 985                 990
Asn Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
        995                 1000                1005
Ile Met Asn Arg Lys Asp Phe Lys Ile Asp Arg Lys Lys Ala Asn Thr
    1010                1015                1020
Gln Asp Leu Arg Lys Lys Glu Lys Glu Asn Arg Lys Leu Gln Leu Glu
1025                1030                1035                1040
Leu Asn Gln Glu Arg Glu Lys Phe Asn Gln Met Val Val Lys His Gln
                1045                1050                1055
Lys Glu Leu Asn Asp Met Gln Ala Gln Leu Val Glu Glu Cys Ala His
            1060                1065                1070
Arg Asn Glu Leu Gln Met Gln Leu Ala Ser Lys Glu Ser Asp Ile Glu
        1075                1080                1085
Gln Leu Arg Ala Lys Leu Leu Asp Leu Ser Asp Ser Thr Ser Val Ala
    1090                1095                1100
Ser Phe Pro Ser Ala Asp Glu Thr Asp Gly Asn Leu Pro Glu Ser Arg
1105                1110                1115                1120
Ile Glu Gly Trp Leu Ser Val Pro Asn Arg Gly Asn Ile Lys Arg Tyr
                1125                1130                1135
Gly Trp Lys Lys Gln Tyr Val Val Val Ser Ser Lys Lys Ile Leu Phe
            1140                1145                1150
Tyr Asn Asp Glu Gln Asp Lys Glu Gln Ser Asn Pro Ser Met Val Leu
        1155                1160                1165
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Gly Asp Val
    1170                1175                1180
Tyr Arg Ala Glu Thr Glu Glu Ile Pro Lys Ile Phe Gln Ile Leu Tyr
1185                1190                1195                1200
Ala Asn Glu Gly Glu Cys Arg Lys Asp Val Glu Met Glu Pro Val Gln
                1205                1210                1215
Gln Ala Glu Lys Thr Asn Phe Gln Asn His Lys Gly His Glu Phe Ile
            1220                1225                1230
Pro Thr Leu Tyr His Phe Pro Ala Asn Cys Asp Ala Cys Ala Lys Pro
        1235                1240                1245
Leu Trp His Val Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
    1250                1255                1260
His Val Lys Cys His Arg Asp His Leu Asp Lys Lys Glu Asp Leu Ile
1265                1270                1275                1280
Cys Pro Cys Lys Val Ser Tyr Asp Val Thr Ser Ala Arg Asp Met Leu
                1285                1290                1295
Leu Leu Ala Cys Ser Gln Asp Glu Gln Lys Lys Trp Val Thr His Leu
            1300                1305                1310
Val Lys Lys Ile Pro Lys Asn Pro Pro Ser Gly Phe Val Arg Ala Ser
        1315                1320                1325
Pro Arg Thr Leu Ser Thr Arg Ser Thr Ala Asn Gln Ser Phe Arg Lys
    1330                1335                1340
Val Val Lys Asn Thr Ser Gly Lys Thr Ser
1345                1350

<210> 1847
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 1847
Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr
 1               5                  10                  15
Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala
            20                  25                  30
Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp
        35                  40                  45
Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys
    50                  55                  60
Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys
65                  70                  75                  80
Lys Ile Lys Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys
                85                  90                  95
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
            100                 105                 110
Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
        115                 120                 125
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
    130                 135                 140
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
145                 150                 155                 160
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
                165                 170                 175
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys
            180                 185                 190
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
        195                 200                 205
Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
    210                 215                 220
His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp
225                 230                 235                 240
Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
                245                 250                 255
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly
            260                 265                 270
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
        275                 280                 285
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
    290                 295                 300
Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu
305                 310                 315                 320
Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
                325                 330                 335
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro
            340                 345                 350
Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala
        355                 360                 365
Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe
    370                 375                 380
Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro
385                 390                 395                 400
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr
                405                 410                 415
Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Asn Asp
            420                 425                 430
Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys
        435                 440                 445
Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu
    450                 455                 460
Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr
465                 470                 475                 480
Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser
                485                 490                 495
Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn
            500                 505                 510
Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn
        515                 520                 525
Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys
    530                 535                 540
Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu
545                 550                 555                 560
Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp
                565                 570                 575
Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile
            580                 585                 590
Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu
        595                 600                 605
Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln
    610                 615                 620
Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile
625                 630                 635                 640
Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys
                645                 650                 655
Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu
            660                 665                 670
Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile
        675                 680                 685
Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu
    690                 695                 700
Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys
705                 710                 715                 720
Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met
                725                 730                 735
Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn
            740                 745                 750
Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu
        755                 760                 765
Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val
    770                 775                 780
Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr
785                 790                 795                 800
Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln
                805                 810                 815
Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn
            820                 825                 830
His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu
        835                 840                 845
Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp
    850                 855                 860
Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val
865                 870                 875                 880
Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu
                885                 890                 895
Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala
            900                 905                 910
Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala
        915                 920                 925
Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile
    930                 935                 940
Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu
945                 950                 955                 960
Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg
                965                 970                 975
Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu
            980                 985                 990
Asn Asn Lys Leu Lys Asp Val Gln Glu Gln Leu Ser Arg Leu Lys Asp
        995                 1000                1005
Glu Glu Ile Ser Ala Ala Ala Ile Lys Ala Gln Phe Glu Lys Gln Leu
    1010                1015                1020
Leu Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
1025                1030                1035                1040
Ile Met Asn Arg Lys Glu Pro Val Lys Arg Gly Asn Asp Thr Asp Val
                1045                1050                1055
Arg Arg Lys Glu Lys Glu Asn Arg Lys Leu His Met Glu Leu Lys Ser
            1060                1065                1070
Glu Arg Glu Lys Leu Thr Gln Gln Met Ile Lys Tyr Gln Lys Glu Leu
        1075                1080                1085
Asn Glu Met Gln Ala Gln Ile Ala Glu Glu Ser Gln Ile Arg Ile Glu
    1090                1095                1100
Leu Gln Met Thr Leu Asp Ser Lys Asp Ser Asp Ile Glu Gln Leu Arg
1105                1110                1115                1120
Ser Gln Leu Gln Ala Leu His Ile Gly Leu Asp Ser Ser Ser Ile Gly
                1125                1130                1135
Ser Gly Pro Gly Asp Ala Glu Ala Asp Asp Gly Phe Pro Glu Ser Arg
            1140                1145                1150
Leu Glu Gly Trp Leu Ser Leu Pro Val Arg Asn Asn Thr Lys Lys Phe
        1155                1160                1165
Gly Trp Val Lys Lys Tyr Val Ile Val Ser Ser Lys Lys Ile Leu Phe
    1170                1175                1180
Tyr Asp Ser Glu Gln Asp Lys Glu Gln Ser Asn Pro Tyr Met Val Leu
1185                1190                1195                1200
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Thr Asp Val
                1205                1210                1215
Tyr Arg Ala Asp Ala Lys Glu Ile Pro Arg Ile Phe Gln Ile Leu Tyr
            1220                1225                1230
Ala Asn Glu Gly Glu Ser Lys Lys Glu Gln Glu Phe Pro Val Glu Pro
        1235                1240                1245
Val Gly Glu Lys Ser Asn Tyr Ile Cys His Lys Gly His Glu Phe Ile
    1250                1255                1260
Pro Thr Leu Tyr His Phe Pro Thr Asn Cys Glu Ala Cys Met Lys Pro
1265                1270                1275                1280
Leu Trp His Met Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
                1285                1290                1295
His Ile Lys Cys His Lys Asp His Met Asp Lys Lys Glu Glu Ile Ile
            1300                1305                1310
Ala Pro Cys Lys Val Tyr Tyr Asp Ile Ser Thr Ala Lys Asn Leu Leu
        1315                1320                1325
Leu Leu Ala Asn Ser Thr Glu Glu Gln Gln Lys Trp Val Ser Arg Leu
    1330                1335                1340
Val Lys Lys Ile Pro Lys Lys Pro Pro Ala Pro Asp Pro Phe Ala Arg
1345                1350                1355                1360
Ser Ser Pro Arg Thr Ser Met Lys Ile Gln Gln Asn Gln Ser Ile Arg
                1365                1370                1375
Arg Pro Ser Arg Gln Leu Ala Pro Asn Lys Pro Ser
            1380                1385

<210> 1848
<211> 1354
<212> PRT
<213> Homo sapiens

<400> 1848
Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn
 1               5                  10                  15
Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp
            20                  25                  30
Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys
        35                  40                  45
Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn
    50                  55                  60
Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys
65                  70                  75                  80
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
                85                  90                  95
Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
            100                 105                 110
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
        115                 120                 125
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
    130                 135                 140
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
145                 150                 155                 160
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg
                165                 170                 175
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
            180                 185                 190
Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
        195                 200                 205
Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn
    210                 215                 220
Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
225                 230                 235                 240
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly
                245                 250                 255
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
            260                 265                 270
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
        275                 280                 285
Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp
    290                 295                 300
Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
305                 310                 315                 320
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu
                325                 330                 335
Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val
            340                 345                 350
Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe
        355                 360                 365
Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro
    370                 375                 380
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr
385                 390                 395                 400
Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr
                405                 410                 415
Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile
            420                 425                 430
Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu
        435                 440                 445
Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met
    450                 455                 460
Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr
465                 470                 475                 480
Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn
                485                 490                 495
Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val
            500                 505                 510
Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys
        515                 520                 525
Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln
    530                 535                 540
Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr
545                 550                 555                 560
Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser
                565                 570                 575
Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu
            580                 585                 590
Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala
        595                 600                 605
Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile
    610                 615                 620
Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His
625                 630                 635                 640
Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln
                645                 650                 655
Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp
            660                 665                 670
Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val
        675                 680                 685
Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser
    690                 695                 700
Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu
705                 710                 715                 720
Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln
                725                 730                 735
Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln
            740                 745                 750
Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu
        755                 760                 765
Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu
    770                 775                 780
Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu
785                 790                 795                 800
Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu
                805                 810                 815
Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr
            820                 825                 830
Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala
        835                 840                 845
Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys
    850                 855                 860
Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu
865                 870                 875                 880
Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu
                885                 890                 895
Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln
            900                 905                 910
Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg
        915                 920                 925
Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala
    930                 935                 940
Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu
945                 950                 955                 960
Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu
                965                 970                 975
Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile
            980                 985                 990
Asn Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
        995                 1000                1005
Ile Met Asn Arg Lys Asp Phe Lys Ile Asp Arg Lys Lys Ala Asn Thr
    1010                1015                1020
Gln Asp Leu Arg Lys Lys Glu Lys Glu Asn Arg Lys Leu Gln Leu Glu
1025                1030                1035                1040
Leu Asn Gln Glu Arg Glu Lys Phe Asn Gln Met Val Val Lys His Gln
                1045                1050                1055
Lys Glu Leu Asn Asp Met Gln Ala Gln Leu Val Glu Glu Cys Ala His
            1060                1065                1070
Arg Asn Glu Leu Gln Met Gln Leu Ala Ser Lys Glu Ser Asp Ile Glu
        1075                1080                1085
Gln Leu Arg Ala Lys Leu Leu Asp Leu Ser Asp Ser Thr Ser Val Ala
    1090                1095                1100
Ser Phe Pro Ser Ala Asp Glu Thr Asp Gly Asn Leu Pro Glu Ser Arg
1105                1110                1115                1120
Ile Glu Gly Trp Leu Ser Val Pro Asn Arg Gly Asn Ile Lys Arg Tyr
                1125                1130                1135
Gly Trp Lys Lys Gln Tyr Val Val Val Ser Ser Lys Lys Ile Leu Phe
            1140                1145                1150
Tyr Asn Asp Glu Gln Asp Lys Glu Gln Ser Asn Pro Ser Met Val Leu
        1155                1160                1165
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Gly Asp Val
    1170                1175                1180
Tyr Arg Ala Glu Thr Glu Glu Ile Pro Lys Ile Phe Gln Ile Leu Tyr
1185                1190                1195                1200
Ala Asn Glu Gly Glu Cys Arg Lys Asp Val Glu Met Glu Pro Val Gln
                1205                1210                1215
Gln Ala Glu Lys Thr Asn Phe Gln Asn His Lys Gly His Glu Phe Ile
            1220                1225                1230
Pro Thr Leu Tyr His Phe Pro Ala Asn Cys Asp Ala Cys Ala Lys Pro
        1235                1240                1245
Leu Trp His Val Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
    1250                1255                1260
His Val Lys Cys His Arg Asp His Leu Asp Lys Lys Glu Asp Leu Ile
1265                1270                1275                1280
Cys Pro Cys Lys Val Ser Tyr Asp Val Thr Ser Ala Arg Asp Met Leu
                1285                1290                1295
Leu Leu Ala Cys Ser Gln Asp Glu Gln Lys Lys Trp Val Thr His Leu
            1300                1305                1310
Val Lys Lys Ile Pro Lys Asn Pro Pro Ser Gly Phe Val Arg Ala Ser
        1315                1320                1325
Pro Arg Thr Leu Ser Thr Arg Ser Thr Ala Asn Gln Ser Phe Arg Lys
    1330                1335                1340
Val Val Lys Asn Thr Ser Gly Lys Thr Ser
1345                1350

<210> 1849
<211> 1354
<212> PRT
<213> Homo sapiens

<400> 1849
Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn
 1               5                  10                  15
Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp
            20                  25                  30
Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys
        35                  40                  45
Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn
    50                  55                  60
Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys
65                  70                  75                  80
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
                85                  90                  95
Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
            100                 105                 110
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
        115                 120                 125
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
    130                 135                 140
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
145                 150                 155                 160
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg
                165                 170                 175
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
            180                 185                 190
Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
        195                 200                 205
Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn
    210                 215                 220
Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
225                 230                 235                 240
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly
                245                 250                 255
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
            260                 265                 270
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
        275                 280                 285
Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp
    290                 295                 300
Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
305                 310                 315                 320
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu
                325                 330                 335
Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val
            340                 345                 350
Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe
        355                 360                 365
Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro
    370                 375                 380
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr
385                 390                 395                 400
Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr
                405                 410                 415
Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile
            420                 425                 430
Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu
        435                 440                 445
Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met
    450                 455                 460
Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr
465                 470                 475                 480
Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn
                485                 490                 495
Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val
            500                 505                 510
Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys
        515                 520                 525
Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln
    530                 535                 540
Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr
545                 550                 555                 560
Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser
                565                 570                 575
Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu
            580                 585                 590
Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala
        595                 600                 605
Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile
    610                 615                 620
Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His
625                 630                 635                 640
Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln
                645                 650                 655
Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp
            660                 665                 670
Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val
        675                 680                 685
Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser
    690                 695                 700
Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu
705                 710                 715                 720
Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln
                725                 730                 735
Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln
            740                 745                 750
Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu
        755                 760                 765
Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu
    770                 775                 780
Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu
785                 790                 795                 800
Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu
                805                 810                 815
Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr
            820                 825                 830
Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala
        835                 840                 845
Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys
    850                 855                 860
Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu
865                 870                 875                 880
Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu
                885                 890                 895
Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln
            900                 905                 910
Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg
        915                 920                 925
Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala
    930                 935                 940
Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu
945                 950                 955                 960
Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu
                965                 970                 975
Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile
            980                 985                 990
Asn Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
        995                 1000                1005
Ile Met Asn Arg Lys Asp Phe Lys Ile Asp Arg Lys Lys Ala Asn Thr
    1010                1015                1020
Gln Asp Leu Arg Lys Lys Glu Lys Glu Asn Arg Lys Leu Gln Leu Glu
1025                1030                1035                1040
Leu Asn Gln Glu Arg Glu Lys Phe Asn Gln Met Val Val Lys His Gln
                1045                1050                1055
Lys Glu Leu Asn Asp Met Gln Ala Gln Leu Val Glu Glu Cys Ala His
            1060                1065                1070
Arg Asn Glu Leu Gln Met Gln Leu Ala Ser Lys Glu Ser Asp Ile Glu
        1075                1080                1085
Gln Leu Arg Ala Lys Leu Leu Asp Leu Ser Asp Ser Thr Ser Val Ala
    1090                1095                1100
Ser Phe Pro Ser Ala Asp Glu Thr Asp Gly Asn Leu Pro Glu Ser Arg
1105                1110                1115                1120
Ile Glu Gly Trp Leu Ser Val Pro Asn Arg Gly Asn Ile Lys Arg Tyr
                1125                1130                1135
Gly Trp Lys Lys Gln Tyr Val Val Val Ser Ser Lys Lys Ile Leu Phe
            1140                1145                1150
Tyr Asn Asp Glu Gln Asp Lys Glu Gln Ser Asn Pro Ser Met Val Leu
        1155                1160                1165
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Gly Asp Val
    1170                1175                1180
Tyr Arg Ala Glu Thr Glu Glu Ile Pro Lys Ile Phe Gln Ile Leu Tyr
1185                1190                1195                1200
Ala Asn Glu Gly Glu Cys Arg Lys Asp Val Glu Met Glu Pro Val Gln
                1205                1210                1215
Gln Ala Glu Lys Thr Asn Phe Gln Asn His Lys Gly His Glu Phe Ile
            1220                1225                1230
Pro Thr Leu Tyr His Phe Pro Ala Asn Cys Asp Ala Cys Ala Lys Pro
        1235                1240                1245
Leu Trp His Val Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
    1250                1255                1260
His Val Lys Cys His Arg Asp His Leu Asp Lys Lys Glu Asp Leu Ile
1265                1270                1275                1280
Cys Pro Cys Lys Val Ser Tyr Asp Val Thr Ser Ala Arg Asp Met Leu
                1285                1290                1295
Leu Leu Ala Cys Ser Gln Asp Glu Gln Lys Lys Trp Val Thr His Leu
            1300                1305                1310
Val Lys Lys Ile Pro Lys Asn Pro Pro Ser Gly Phe Val Arg Ala Ser
        1315                1320                1325
Pro Arg Thr Leu Ser Thr Arg Ser Thr Ala Asn Gln Ser Phe Arg Lys
    1330                1335                1340
Val Val Lys Asn Thr Ser Gly Lys Thr Ser
1345                1350

<210> 1850
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 1850
Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr
 1               5                  10                  15
Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala
            20                  25                  30
Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp
        35                  40                  45
Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys
    50                  55                  60
Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys
65                  70                  75                  80
Lys Ile Lys Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys
                85                  90                  95
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
            100                 105                 110
Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
        115                 120                 125
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
    130                 135                 140
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
145                 150                 155                 160
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
                165                 170                 175
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys
            180                 185                 190
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
        195                 200                 205
Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
    210                 215                 220
His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp
225                 230                 235                 240
Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
                245                 250                 255
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly
            260                 265                 270
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
        275                 280                 285
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
    290                 295                 300
Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu
305                 310                 315                 320
Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
                325                 330                 335
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro
            340                 345                 350
Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala
        355                 360                 365
Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe
    370                 375                 380
Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro
385                 390                 395                 400
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr
                405                 410                 415
Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Asn Asp
            420                 425                 430
Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys
        435                 440                 445
Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu
    450                 455                 460
Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr
465                 470                 475                 480
Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser
                485                 490                 495
Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn
            500                 505                 510
Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn
        515                 520                 525
Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys
    530                 535                 540
Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu
545                 550                 555                 560
Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp
                565                 570                 575
Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile
            580                 585                 590
Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu
        595                 600                 605
Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln
    610                 615                 620
Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile
625                 630                 635                 640
Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys
                645                 650                 655
Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu
            660                 665                 670
Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile
        675                 680                 685
Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu
    690                 695                 700
Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys
705                 710                 715                 720
Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met
                725                 730                 735
Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn
            740                 745                 750
Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu
        755                 760                 765
Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val
    770                 775                 780
Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr
785                 790                 795                 800
Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln
                805                 810                 815
Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn
            820                 825                 830
His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu
        835                 840                 845
Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp
    850                 855                 860
Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val
865                 870                 875                 880
Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu
                885                 890                 895
Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala
            900                 905                 910
Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala
        915                 920                 925
Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile
    930                 935                 940
Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu
945                 950                 955                 960
Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg
                965                 970                 975
Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu
            980                 985                 990
Asn Asn Lys Leu Lys Asp Val Gln Glu Gln Leu Ser Arg Leu Lys Asp
        995                 1000                1005
Glu Glu Ile Ser Ala Ala Ala Ile Lys Ala Gln Phe Glu Lys Gln Leu
    1010                1015                1020
Leu Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
1025                1030                1035                1040
Ile Met Asn Arg Lys Glu Pro Val Lys Arg Gly Asn Asp Thr Asp Val
                1045                1050                1055
Arg Arg Lys Glu Lys Glu Asn Arg Lys Leu His Met Glu Leu Lys Ser
            1060                1065                1070
Glu Arg Glu Lys Leu Thr Gln Gln Met Ile Lys Tyr Gln Lys Glu Leu
        1075                1080                1085
Asn Glu Met Gln Ala Gln Ile Ala Glu Glu Ser Gln Ile Arg Ile Glu
    1090                1095                1100
Leu Gln Met Thr Leu Asp Ser Lys Asp Ser Asp Ile Glu Gln Leu Arg
1105                1110                1115                1120
Ser Gln Leu Gln Ala Leu His Ile Gly Leu Asp Ser Ser Ser Ile Gly
                1125                1130                1135
Ser Gly Pro Gly Asp Ala Glu Ala Asp Asp Gly Phe Pro Glu Ser Arg
            1140                1145                1150
Leu Glu Gly Trp Leu Ser Leu Pro Val Arg Asn Asn Thr Lys Lys Phe
        1155                1160                1165
Gly Trp Val Lys Lys Tyr Val Ile Val Ser Ser Lys Lys Ile Leu Phe
    1170                1175                1180
Tyr Asp Ser Glu Gln Asp Lys Glu Gln Ser Asn Pro Tyr Met Val Leu
1185                1190                1195                1200
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Thr Asp Val
                1205                1210                1215
Tyr Arg Ala Asp Ala Lys Glu Ile Pro Arg Ile Phe Gln Ile Leu Tyr
            1220                1225                1230
Ala Asn Glu Gly Glu Ser Lys Lys Glu Gln Glu Phe Pro Val Glu Pro
        1235                1240                1245
Val Gly Glu Lys Ser Asn Tyr Ile Cys His Lys Gly His Glu Phe Ile
    1250                1255                1260
Pro Thr Leu Tyr His Phe Pro Thr Asn Cys Glu Ala Cys Met Lys Pro
1265                1270                1275                1280
Leu Trp His Met Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
                1285                1290                1295
His Ile Lys Cys His Lys Asp His Met Asp Lys Lys Glu Glu Ile Ile
            1300                1305                1310
Ala Pro Cys Lys Val Tyr Tyr Asp Ile Ser Thr Ala Lys Asn Leu Leu
        1315                1320                1325
Leu Leu Ala Asn Ser Thr Glu Glu Gln Gln Lys Trp Val Ser Arg Leu
    1330                1335                1340
Val Lys Lys Ile Pro Lys Lys Pro Pro Ala Pro Asp Pro Phe Ala Arg
1345                1350                1355                1360
Ser Ser Pro Arg Thr Ser Met Lys Ile Gln Gln Asn Gln Ser Ile Arg
                1365                1370                1375
Arg Pro Ser Arg Gln Leu Ala Pro Asn Lys Pro Ser
            1380                1385

<210> 1851
<211> 1354
<212> PRT
<213> Homo sapiens

<400> 1851
Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn
 1               5                  10                  15
Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp
            20                  25                  30
Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys
        35                  40                  45
Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn
    50                  55                  60
Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys
65                  70                  75                  80
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
                85                  90                  95
Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
            100                 105                 110
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
        115                 120                 125
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
    130                 135                 140
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
145                 150                 155                 160
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg
                165                 170                 175
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
            180                 185                 190
Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
        195                 200                 205
Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn
    210                 215                 220
Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
225                 230                 235                 240
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly
                245                 250                 255
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
            260                 265                 270
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
        275                 280                 285
Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp
    290                 295                 300
Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
305                 310                 315                 320
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu
                325                 330                 335
Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val
            340                 345                 350
Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe
        355                 360                 365
Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro
    370                 375                 380
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr
385                 390                 395                 400
Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr
                405                 410                 415
Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile
            420                 425                 430
Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu
        435                 440                 445
Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met
    450                 455                 460
Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr
465                 470                 475                 480
Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn
                485                 490                 495
Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val
            500                 505                 510
Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys
        515                 520                 525
Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln
    530                 535                 540
Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr
545                 550                 555                 560
Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser
                565                 570                 575
Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu
            580                 585                 590
Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala
        595                 600                 605
Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile
    610                 615                 620
Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His
625                 630                 635                 640
Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln
                645                 650                 655
Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp
            660                 665                 670
Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val
        675                 680                 685
Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser
    690                 695                 700
Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu
705                 710                 715                 720
Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln
                725                 730                 735
Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln
            740                 745                 750
Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu
        755                 760                 765
Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu
    770                 775                 780
Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu
785                 790                 795                 800
Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu
                805                 810                 815
Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr
            820                 825                 830
Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala
        835                 840                 845
Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys
    850                 855                 860
Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu
865                 870                 875                 880
Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu
                885                 890                 895
Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln
            900                 905                 910
Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg
        915                 920                 925
Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala
    930                 935                 940
Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu
945                 950                 955                 960
Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu
                965                 970                 975
Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile
            980                 985                 990
Asn Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
        995                 1000                1005
Ile Met Asn Arg Lys Asp Phe Lys Ile Asp Arg Lys Lys Ala Asn Thr
    1010                1015                1020
Gln Asp Leu Arg Lys Lys Glu Lys Glu Asn Arg Lys Leu Gln Leu Glu
1025                1030                1035                1040
Leu Asn Gln Glu Arg Glu Lys Phe Asn Gln Met Val Val Lys His Gln
                1045                1050                1055
Lys Glu Leu Asn Asp Met Gln Ala Gln Leu Val Glu Glu Cys Ala His
            1060                1065                1070
Arg Asn Glu Leu Gln Met Gln Leu Ala Ser Lys Glu Ser Asp Ile Glu
        1075                1080                1085
Gln Leu Arg Ala Lys Leu Leu Asp Leu Ser Asp Ser Thr Ser Val Ala
    1090                1095                1100
Ser Phe Pro Ser Ala Asp Glu Thr Asp Gly Asn Leu Pro Glu Ser Arg
1105                1110                1115                1120
Ile Glu Gly Trp Leu Ser Val Pro Asn Arg Gly Asn Ile Lys Arg Tyr
                1125                1130                1135
Gly Trp Lys Lys Gln Tyr Val Val Val Ser Ser Lys Lys Ile Leu Phe
            1140                1145                1150
Tyr Asn Asp Glu Gln Asp Lys Glu Gln Ser Asn Pro Ser Met Val Leu
        1155                1160                1165
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Gly Asp Val
    1170                1175                1180
Tyr Arg Ala Glu Thr Glu Glu Ile Pro Lys Ile Phe Gln Ile Leu Tyr
1185                1190                1195                1200
Ala Asn Glu Gly Glu Cys Arg Lys Asp Val Glu Met Glu Pro Val Gln
                1205                1210                1215
Gln Ala Glu Lys Thr Asn Phe Gln Asn His Lys Gly His Glu Phe Ile
            1220                1225                1230
Pro Thr Leu Tyr His Phe Pro Ala Asn Cys Asp Ala Cys Ala Lys Pro
        1235                1240                1245
Leu Trp His Val Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
    1250                1255                1260
His Val Lys Cys His Arg Asp His Leu Asp Lys Lys Glu Asp Leu Ile
1265                1270                1275                1280
Cys Pro Cys Lys Val Ser Tyr Asp Val Thr Ser Ala Arg Asp Met Leu
                1285                1290                1295
Leu Leu Ala Cys Ser Gln Asp Glu Gln Lys Lys Trp Val Thr His Leu
            1300                1305                1310
Val Lys Lys Ile Pro Lys Asn Pro Pro Ser Gly Phe Val Arg Ala Ser
        1315                1320                1325
Pro Arg Thr Leu Ser Thr Arg Ser Thr Ala Asn Gln Ser Phe Arg Lys
    1330                1335                1340
Val Val Lys Asn Thr Ser Gly Lys Thr Ser
1345                1350

<210> 1852
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 1852
Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr
 1               5                  10                  15
Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala
            20                  25                  30
Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp
        35                  40                  45
Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys
    50                  55                  60
Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys
65                  70                  75                  80
Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys
                85                  90                  95
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
            100                 105                 110
Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
        115                 120                 125
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
    130                 135                 140
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
145                 150                 155                 160
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
                165                 170                 175
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys
            180                 185                 190
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
        195                 200                 205
Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
    210                 215                 220
His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp
225                 230                 235                 240
Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
                245                 250                 255
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly
            260                 265                 270
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
        275                 280                 285
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
    290                 295                 300
Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu
305                 310                 315                 320
Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
                325                 330                 335
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro
            340                 345                 350
Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala
        355                 360                 365
Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe
    370                 375                 380
Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro
385                 390                 395                 400
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr
                405                 410                 415
Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Asn Asp
            420                 425                 430
Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys
        435                 440                 445
Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu
    450                 455                 460
Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr
465                 470                 475                 480
Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser
                485                 490                 495
Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn
            500                 505                 510
Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn
        515                 520                 525
Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys
    530                 535                 540
Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu
545                 550                 555                 560
Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp
                565                 570                 575
Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile
            580                 585                 590
Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu
        595                 600                 605
Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln
    610                 615                 620
Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile
625                 630                 635                 640
Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys
                645                 650                 655
Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu
            660                 665                 670
Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile
        675                 680                 685
Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu
    690                 695                 700
Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys
705                 710                 715                 720
Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met
                725                 730                 735
Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn
            740                 745                 750
Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu
        755                 760                 765
Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val
    770                 775                 780
Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr
785                 790                 795                 800
Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln
                805                 810                 815
Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn
            820                 825                 830
His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu
        835                 840                 845
Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp
    850                 855                 860
Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val
865                 870                 875                 880
Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu
                885                 890                 895
Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala
            900                 905                 910
Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala
        915                 920                 925
Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile
    930                 935                 940
Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu
945                 950                 955                 960
Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg
                965                 970                 975
Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu
            980                 985                 990
Asn Asn Lys Leu Lys Asp Val Gln Glu Gln Leu Ser Arg Leu Lys Asp
        995                 1000                1005
Glu Glu Ile Ser Ala Ala Ala Ile Lys Ala Gln Phe Glu Lys Gln Leu
    1010                1015                1020
Leu Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
1025                1030                1035                1040
Ile Met Asn Arg Lys Glu Pro Val Lys Arg Gly Asn Asp Thr Asp Val
                1045                1050                1055
Arg Arg Lys Glu Lys Glu Asn Arg Lys Leu His Met Glu Leu Lys Ser
            1060                1065                1070
Glu Arg Glu Lys Leu Thr Gln Gln Met Ile Lys Tyr Gln Lys Glu Leu
        1075                1080                1085
Asn Glu Met Gln Ala Gln Ile Ala Glu Glu Ser Gln Ile Arg Ile Glu
    1090                1095                1100
Leu Gln Met Thr Leu Asp Ser Lys Asp Ser Asp Ile Glu Gln Leu Arg
1105                1110                1115                1120
Ser Gln Leu Gln Ala Leu His Ile Gly Leu Asp Ser Ser Ser Ile Gly
                1125                1130                1135
Ser Gly Pro Gly Asp Ala Glu Ala Asp Asp Gly Phe Pro Glu Ser Arg
            1140                1145                1150
Leu Glu Gly Trp Leu Ser Leu Pro Val Arg Asn Asn Thr Lys Lys Phe
        1155                1160                1165
Gly Trp Val Lys Lys Tyr Val Ile Val Ser Ser Lys Lys Ile Leu Phe
    1170                1175                1180
Tyr Asp Ser Glu Gln Asp Lys Glu Gln Ser Asn Pro Tyr Met Val Leu
1185                1190                1195                1200
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Thr Asp Val
                1205                1210                1215
Tyr Arg Ala Asp Ala Lys Glu Ile Pro Arg Ile Phe Gln Ile Leu Tyr
            1220                1225                1230
Ala Asn Glu Gly Glu Ser Lys Lys Glu Gln Glu Phe Pro Val Glu Pro
        1235                1240                1245
Val Gly Glu Lys Ser Asn Tyr Ile Cys His Lys Gly His Glu Phe Ile
    1250                1255                1260
Pro Thr Leu Tyr His Phe Pro Thr Asn Cys Glu Ala Cys Met Lys Pro
1265                1270                1275                1280
Leu Trp His Met Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
                1285                1290                1295
His Ile Lys Cys His Lys Asp His Met Asp Lys Lys Glu Glu Ile Ile
            1300                1305                1310
Ala Pro Cys Lys Val Tyr Tyr Asp Ile Ser Thr Ala Lys Asn Leu Leu
        1315                1320                1325
Leu Leu Ala Asn Ser Thr Glu Glu Gln Gln Lys Trp Val Ser Arg Leu
    1330                1335                1340
Val Lys Lys Ile Pro Lys Lys Pro Pro Ala Pro Asp Pro Phe Ala Arg
1345                1350                1355                1360
Ser Ser Pro Arg Thr Ser Met Lys Ile Gln Gln Asn Gln Ser Ile Arg
                1365                1370                1375
Arg Pro Ser Arg Gln Leu Ala Pro Asn Lys Pro Ser
            1380                1385

<210> 1853
<211> 1354
<212> PRT
<213> Homo sapiens

<400> 1853
Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn
 1               5                  10                  15
Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp
            20                  25                  30
Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys
        35                  40                  45
Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn
    50                  55                  60
Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys
65                  70                  75                  80
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
                85                  90                  95
Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
            100                 105                 110
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
        115                 120                 125
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
    130                 135                 140
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
145                 150                 155                 160
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg
                165                 170                 175
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
            180                 185                 190
Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
        195                 200                 205
Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn
    210                 215                 220
Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
225                 230                 235                 240
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly
                245                 250                 255
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
            260                 265                 270
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
        275                 280                 285
Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp
    290                 295                 300
Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
305                 310                 315                 320
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu
                325                 330                 335
Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val
            340                 345                 350
Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe
        355                 360                 365
Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro
    370                 375                 380
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr
385                 390                 395                 400
Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr
                405                 410                 415
Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile
            420                 425                 430
Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu
        435                 440                 445
Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met
    450                 455                 460
Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr
465                 470                 475                 480
Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn
                485                 490                 495
Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val
            500                 505                 510
Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys
        515                 520                 525
Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln
    530                 535                 540
Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr
545                 550                 555                 560
Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser
                565                 570                 575
Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu
            580                 585                 590
Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala
        595                 600                 605
Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile
    610                 615                 620
Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His
625                 630                 635                 640
Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln
                645                 650                 655
Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp
            660                 665                 670
Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val
        675                 680                 685
Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser
    690                 695                 700
Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu
705                 710                 715                 720
Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln
                725                 730                 735
Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln
            740                 745                 750
Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu
        755                 760                 765
Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu
    770                 775                 780
Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu
785                 790                 795                 800
Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu
                805                 810                 815
Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr
            820                 825                 830
Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala
        835                 840                 845
Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys
    850                 855                 860
Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu
865                 870                 875                 880
Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu
                885                 890                 895
Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln
            900                 905                 910
Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg
        915                 920                 925
Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala
    930                 935                 940
Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu
945                 950                 955                 960
Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu
                965                 970                 975
Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile
            980                 985                 990
Asn Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
        995                 1000                1005
Ile Met Asn Arg Lys Asp Phe Lys Ile Asp Arg Lys Lys Ala Asn Thr
    1010                1015                1020
Gln Asp Leu Arg Lys Lys Glu Lys Glu Asn Arg Lys Leu Gln Leu Glu
1025                1030                1035                1040
Leu Asn Gln Glu Arg Glu Lys Phe Asn Gln Met Val Val Lys His Gln
                1045                1050                1055
Lys Glu Leu Asn Asp Met Gln Ala Gln Leu Val Glu Glu Cys Ala His
            1060                1065                1070
Arg Asn Glu Leu Gln Met Gln Leu Ala Ser Lys Glu Ser Asp Ile Glu
        1075                1080                1085
Gln Leu Arg Ala Lys Leu Leu Asp Leu Ser Asp Ser Thr Ser Val Ala
    1090                1095                1100
Ser Phe Pro Ser Ala Asp Glu Thr Asp Gly Asn Leu Pro Glu Ser Arg
1105                1110                1115                1120
Ile Glu Gly Trp Leu Ser Val Pro Asn Arg Gly Asn Ile Lys Arg Tyr
                1125                1130                1135
Gly Trp Lys Lys Gln Tyr Val Val Val Ser Ser Lys Lys Ile Leu Phe
            1140                1145                1150
Tyr Asn Asp Glu Gln Asp Lys Glu Gln Ser Asn Pro Ser Met Val Leu
        1155                1160                1165
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Gly Asp Val
    1170                1175                1180
Tyr Arg Ala Glu Thr Glu Glu Ile Pro Lys Ile Phe Gln Ile Leu Tyr
1185                1190                1195                1200
Ala Asn Glu Gly Glu Cys Arg Lys Asp Val Glu Met Glu Pro Val Gln
                1205                1210                1215
Gln Ala Glu Lys Thr Asn Phe Gln Asn His Lys Gly His Glu Phe Ile
            1220                1225                1230
Pro Thr Leu Tyr His Phe Pro Ala Asn Cys Asp Ala Cys Ala Lys Pro
        1235                1240                1245
Leu Trp His Val Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
    1250                1255                1260
His Val Lys Cys His Arg Asp His Leu Asp Lys Lys Glu Asp Leu Ile
1265                1270                1275                1280
Cys Pro Cys Lys Val Ser Tyr Asp Val Thr Ser Ala Arg Asp Met Leu
                1285                1290                1295
Leu Leu Ala Cys Ser Gln Asp Glu Gln Lys Lys Trp Val Thr His Leu
            1300                1305                1310
Val Lys Lys Ile Pro Lys Asn Pro Pro Ser Gly Phe Val Arg Ala Ser
        1315                1320                1325
Pro Arg Thr Leu Ser Thr Arg Ser Thr Ala Asn Gln Ser Phe Arg Lys
    1330                1335                1340
Val Val Lys Asn Thr Ser Gly Lys Thr Ser
1345                1350

<210> 1854
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 1854
Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr
 1               5                  10                  15
Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala
            20                  25                  30
Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp
        35                  40                  45
Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys
    50                  55                  60
Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys
65                  70                  75                  80
Lys Ile Lys Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys
                85                  90                  95
Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys
            100                 105                 110
Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met
        115                 120                 125
Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met
    130                 135                 140
Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln
145                 150                 155                 160
Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp
                165                 170                 175
Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys
            180                 185                 190
Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met
        195                 200                 205
Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys
    210                 215                 220
His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp
225                 230                 235                 240
Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr
                245                 250                 255
Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly
            260                 265                 270
Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu
        275                 280                 285
Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser
    290                 295                 300
Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu
305                 310                 315                 320
Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg
                325                 330                 335
Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro
            340                 345                 350
Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala
        355                 360                 365
Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe
    370                 375                 380
Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro
385                 390                 395                 400
Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr
                405                 410                 415
Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Asn Asp
            420                 425                 430
Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys
        435                 440                 445
Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu
    450                 455                 460
Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr
465                 470                 475                 480
Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser
                485                 490                 495
Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn
            500                 505                 510
Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn
        515                 520                 525
Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys
    530                 535                 540
Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu
545                 550                 555                 560
Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp
                565                 570                 575
Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile
            580                 585                 590
Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu
        595                 600                 605
Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln
    610                 615                 620
Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile
625                 630                 635                 640
Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys
                645                 650                 655
Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu
            660                 665                 670
Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile
        675                 680                 685
Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu
    690                 695                 700
Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys
705                 710                 715                 720
Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met
                725                 730                 735
Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn
            740                 745                 750
Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu
        755                 760                 765
Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val
    770                 775                 780
Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr
785                 790                 795                 800
Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln
                805                 810                 815
Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn
            820                 825                 830
His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu
        835                 840                 845
Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp
    850                 855                 860
Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val
865                 870                 875                 880
Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu
                885                 890                 895
Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala
            900                 905                 910
Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala
        915                 920                 925
Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile
    930                 935                 940
Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu
945                 950                 955                 960
Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg
                965                 970                 975
Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu
            980                 985                 990
Asn Asn Lys Leu Lys Asp Val Gln Glu Gln Leu Ser Arg Leu Lys Asp
        995                 1000                1005
Glu Glu Ile Ser Ala Ala Ala Ile Lys Ala Gln Phe Glu Lys Gln Leu
    1010                1015                1020
Leu Thr Glu Arg Thr Leu Lys Thr Gln Ala Val Asn Lys Leu Ala Glu
1025                1030                1035                1040
Ile Met Asn Arg Lys Glu Pro Val Lys Arg Gly Asn Asp Thr Asp Val
                1045                1050                1055
Arg Arg Lys Glu Lys Glu Asn Arg Lys Leu His Met Glu Leu Lys Ser
            1060                1065                1070
Glu Arg Glu Lys Leu Thr Gln Gln Met Ile Lys Tyr Gln Lys Glu Leu
        1075                1080                1085
Asn Glu Met Gln Ala Gln Ile Ala Glu Glu Ser Gln Ile Arg Ile Glu
    1090                1095                1100
Leu Gln Met Thr Leu Asp Ser Lys Asp Ser Asp Ile Glu Gln Leu Arg
1105                1110                1115                1120
Ser Gln Leu Gln Ala Leu His Ile Gly Leu Asp Ser Ser Ser Ile Gly
                1125                1130                1135
Ser Gly Pro Gly Asp Ala Glu Ala Asp Asp Gly Phe Pro Glu Ser Arg
            1140                1145                1150
Leu Glu Gly Trp Leu Ser Leu Pro Val Arg Asn Asn Thr Lys Lys Phe
        1155                1160                1165
Gly Trp Val Lys Lys Tyr Val Ile Val Ser Ser Lys Lys Ile Leu Phe
    1170                1175                1180
Tyr Asp Ser Glu Gln Asp Lys Glu Gln Ser Asn Pro Tyr Met Val Leu
1185                1190                1195                1200
Asp Ile Asp Lys Leu Phe His Val Arg Pro Val Thr Gln Thr Asp Val
                1205                1210                1215
Tyr Arg Ala Asp Ala Lys Glu Ile Pro Arg Ile Phe Gln Ile Leu Tyr
            1220                1225                1230
Ala Asn Glu Gly Glu Ser Lys Lys Glu Gln Glu Phe Pro Val Glu Pro
        1235                1240                1245
Val Gly Glu Lys Ser Asn Tyr Ile Cys His Lys Gly His Glu Phe Ile
    1250                1255                1260
Pro Thr Leu Tyr His Phe Pro Thr Asn Cys Glu Ala Cys Met Lys Pro
1265                1270                1275                1280
Leu Trp His Met Phe Lys Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys
                1285                1290                1295
His Ile Lys Cys His Lys Asp His Met Asp Lys Lys Glu Glu Ile Ile
            1300                1305                1310
Ala Pro Cys Lys Val Tyr Tyr Asp Ile Ser Thr Ala Lys Asn Leu Leu
        1315                1320                1325
Leu Leu Ala Asn Ser Thr Glu Glu Gln Gln Lys Trp Val Ser Arg Leu
    1330                1335                1340
Val Lys Lys Ile Pro Lys Lys Pro Pro Ala Pro Asp Pro Phe Ala Arg
1345                1350                1355                1360
Ser Ser Pro Arg Thr Ser Met Lys Ile Gln Gln Asn Gln Ser Ile Arg
                1365                1370                1375
Arg Pro Ser Arg Gln Leu Ala Pro Asn Lys Pro Ser
            1380                1385

<210> 1855
<211> 140
<212> PRT
<213> Homo sapiens

<400> 1855
Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr
 1               5                  10                  15
Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp
            20                  25                  30
Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val
        35                  40                  45
Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu
    50                  55                  60
Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln
65                  70                  75                  80
Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala
                85                  90                  95
Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu
            100                 105                 110
Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys
        115                 120                 125
Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr
    130                 135                 140

<210> 1856
<211> 140
<212> PRT
<213> Homo sapiens

<400> 1856
Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr
 1               5                  10                  15
Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp
            20                  25                  30
Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val
        35                  40                  45
Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu
    50                  55                  60
Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln
65                  70                  75                  80
Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala
                85                  90                  95
Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu
            100                 105                 110
Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys
        115                 120                 125
Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr
    130                 135                 140

<210> 1857
<211> 140
<212> PRT
<213> Homo sapiens

<400> 1857
Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr
 1               5                  10                  15
Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp
            20                  25                  30
Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val
        35                  40                  45
Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu
    50                  55                  60
Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln
65                  70                  75                  80
Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala
                85                  90                  95
Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu
            100                 105                 110
Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys
        115                 120                 125
Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr
    130                 135                 140

<210> 1858
<211> 140
<212> PRT
<213> Homo sapiens

<400> 1858
Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr
 1               5                  10                  15
Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp
            20                  25                  30
Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val
        35                  40                  45
Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu
    50                  55                  60
Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln
65                  70                  75                  80
Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala
                85                  90                  95
Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu
            100                 105                 110
Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys
        115                 120                 125
Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr
    130                 135                 140

<210> 1859
<211> 140
<212> PRT
<213> Homo sapiens

<400> 1859
Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr
 1               5                  10                  15
Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp
            20                  25                  30
Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val
        35                  40                  45
Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu
    50                  55                  60
Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln
65                  70                  75                  80
Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala
                85                  90                  95
Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu
            100                 105                 110
Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys
        115                 120                 125
Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr
    130                 135                 140

<210> 1860
<211> 140
<212> PRT
<213> Homo sapiens

<400> 1860
Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr
 1               5                  10                  15
Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp
            20                  25                  30
Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val
        35                  40                  45
Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu
    50                  55                  60
Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln
65                  70                  75                  80
Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala
                85                  90                  95
Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu
            100                 105                 110
Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys
        115                 120                 125
Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr
    130                 135                 140

<210> 1861
<211> 139
<212> PRT
<213> Homo sapiens

<400> 1861
Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr Cys
 1               5                  10                  15
Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp Ala
            20                  25                  30
Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val Gly
        35                  40                  45
Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu Thr
    50                  55                  60
Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln Asp
65                  70                  75                  80
Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala Pro
                85                  90                  95
Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu Leu
            100                 105                 110
Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys Tyr
        115                 120                 125
Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr
    130                 135

<210> 1862
<211> 61
<212> PRT
<213> Homo sapiens

<400> 1862
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg
    50                  55                  60

<210> 1863
<211> 331
<212> PRT
<213> Homo sapiens

<400> 1863
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95
Glu Gly Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
            100                 105                 110
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
        115                 120                 125
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
    130                 135                 140
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
145                 150                 155                 160
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                165                 170                 175
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
            180                 185                 190
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
        195                 200                 205
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
    210                 215                 220
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
225                 230                 235                 240
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                245                 250                 255
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
            260                 265                 270
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
        275                 280                 285
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
    290                 295                 300
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
305                 310                 315                 320
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330

<210> 1864
<211> 316
<212> PRT
<213> Homo sapiens

<400> 1864
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95
Glu Gly Ser Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
            100                 105                 110
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
        115                 120                 125
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
    130                 135                 140
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
145                 150                 155                 160
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
                165                 170                 175
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
            180                 185                 190
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
        195                 200                 205
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
    210                 215                 220
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
225                 230                 235                 240
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
                245                 250                 255
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
            260                 265                 270
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
        275                 280                 285
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
    290                 295                 300
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
305                 310                 315

<210> 1865
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1865
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1866
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1866
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1867
<211> 210
<212> PRT
<213> Homo sapiens

<400> 1867
Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu
 1               5                  10                  15
Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu
            20                  25                  30
Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys
        35                  40                  45
Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser
    50                  55                  60
Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser
65                  70                  75                  80
Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His
                85                  90                  95
Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu
            100                 105                 110
Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu
        115                 120                 125
Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr
    130                 135                 140
Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile
145                 150                 155                 160
Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile
                165                 170                 175
Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys
            180                 185                 190
Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln
        195                 200                 205
Cys Asn
    210

<210> 1868
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1868
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1869
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1869
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1870
<211> 527
<212> PRT
<213> Homo sapiens

<400> 1870
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly
            260                 265                 270
Phe Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala
        275                 280                 285
Lys Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro
    290                 295                 300
Ile Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val
305                 310                 315                 320
Cys Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys
                325                 330                 335
Thr Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu
            340                 345                 350
Pro Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly
        355                 360                 365
Ser Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val
    370                 375                 380
Cys Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr
385                 390                 395                 400
Val His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys
                405                 410                 415
Lys Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys
            420                 425                 430
Gln Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp
        435                 440                 445
Pro Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val
    450                 455                 460
Leu Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu
465                 470                 475                 480
Lys Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu
                485                 490                 495
Lys Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala
            500                 505                 510
Ala Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520                 525

<210> 1871
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1871
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1872
<211> 527
<212> PRT
<213> Homo sapiens

<400> 1872
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Ser Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly
            260                 265                 270
Phe Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala
        275                 280                 285
Lys Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro
    290                 295                 300
Ile Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val
305                 310                 315                 320
Cys Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys
                325                 330                 335
Thr Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu
            340                 345                 350
Pro Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly
        355                 360                 365
Ser Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val
    370                 375                 380
Cys Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr
385                 390                 395                 400
Val His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys
                405                 410                 415
Lys Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys
            420                 425                 430
Gln Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp
        435                 440                 445
Pro Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val
    450                 455                 460
Leu Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu
465                 470                 475                 480
Lys Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu
                485                 490                 495
Lys Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala
            500                 505                 510
Ala Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520                 525

<210> 1873
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1873
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1874
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1874
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Ser Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1875
<211> 526
<212> PRT
<213> Homo sapiens

<400> 1875
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Ser Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe
            260                 265                 270
Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys
        275                 280                 285
Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile
    290                 295                 300
Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys
305                 310                 315                 320
Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr
                325                 330                 335
Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro
            340                 345                 350
Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser
        355                 360                 365
Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys
    370                 375                 380
Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val
385                 390                 395                 400
His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys
                405                 410                 415
Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln
            420                 425                 430
Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro
        435                 440                 445
Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu
    450                 455                 460
Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys
465                 470                 475                 480
Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys
                485                 490                 495
Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala
            500                 505                 510
Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520                 525

<210> 1876
<211> 527
<212> PRT
<213> Homo sapiens

<400> 1876
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly
            260                 265                 270
Phe Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala
        275                 280                 285
Lys Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro
    290                 295                 300
Ile Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val
305                 310                 315                 320
Cys Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys
                325                 330                 335
Thr Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu
            340                 345                 350
Pro Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly
        355                 360                 365
Ser Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val
    370                 375                 380
Cys Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr
385                 390                 395                 400
Val His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys
                405                 410                 415
Lys Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys
            420                 425                 430
Gln Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp
        435                 440                 445
Pro Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val
    450                 455                 460
Leu Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu
465                 470                 475                 480
Lys Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu
                485                 490                 495
Lys Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala
            500                 505                 510
Ala Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520                 525

<210> 1877
<211> 523
<212> PRT
<213> Homo sapiens

<400> 1877
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Leu Cys Glu Ser Leu Gln Lys His Leu
    130                 135                 140
Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro Glu
145                 150                 155                 160
Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro Leu
                165                 170                 175
Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys Asp
            180                 185                 190
Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile Gln
        195                 200                 205
Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu His
    210                 215                 220
Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile Cys
225                 230                 235                 240
Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met Met
                245                 250                 255
His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp Glu
            260                 265                 270
Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala Ser
        275                 280                 285
Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys His
    290                 295                 300
Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe Leu
305                 310                 315                 320
Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys Glu
                325                 330                 335
Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser Leu
            340                 345                 350
Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile Leu
        355                 360                 365
Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met Leu
    370                 375                 380
His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val Thr
385                 390                 395                 400
Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val Gly
                405                 410                 415
Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile Leu
            420                 425                 430
Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln Lys
        435                 440                 445
Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu Ile
    450                 455                 460
Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly Ala
465                 470                 475                 480
Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile Trp
                485                 490                 495
Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys Asn
            500                 505                 510
Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1878
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1878
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1879
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1879
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1880
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1880
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1881
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1881
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1882
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1882
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520

<210> 1883
<211> 265
<212> PRT
<213> Homo sapiens

<400> 1883
Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn
            20                  25                  30
Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His
                85                  90                  95
Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn
            100                 105                 110
Val Thr His Asn Asp Ala Gly Phe Tyr Thr Leu His Val Ile Lys Glu
        115                 120                 125
Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu
    130                 135                 140
Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn
145                 150                 155                 160
Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr
                165                 170                 175
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu
            180                 185                 190
Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys
        195                 200                 205
Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala
    210                 215                 220
Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln
225                 230                 235                 240
Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile
                245                 250                 255
Gly Val Leu Ala Gly Met Ala Leu Ile
            260                 265

<210> 1884
<211> 265
<212> PRT
<213> Homo sapiens

<400> 1884
Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn
            20                  25                  30
Ser Ala Gln Thr Asn Ile Asp Gly Val Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Gln Arg Val His Ala Asn Tyr Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His
                85                  90                  95
Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn
            100                 105                 110
Val Thr His Asn Asp Ala Gly Phe Tyr Thr Leu His Val Ile Lys Glu
        115                 120                 125
Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu
    130                 135                 140
Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn
145                 150                 155                 160
Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr
                165                 170                 175
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu
            180                 185                 190
Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys
        195                 200                 205
Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala
    210                 215                 220
Ser Arg Ser Asp Pro Val Thr Leu Asn Val Cys Tyr Glu Ser Val Gln
225                 230                 235                 240
Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile
                245                 250                 255
Gly Val Leu Ala Gly Met Ala Leu Ile
            260                 265

<210> 1885
<211> 265
<212> PRT
<213> Homo sapiens

<400> 1885
Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn
            20                  25                  30
Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His
                85                  90                  95
Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn
            100                 105                 110
Val Thr His Asn Asp Ala Gly Phe Tyr Thr Leu His Val Ile Lys Glu
        115                 120                 125
Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu
    130                 135                 140
Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn
145                 150                 155                 160
Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr
                165                 170                 175
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu
            180                 185                 190
Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys
        195                 200                 205
Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala
    210                 215                 220
Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln
225                 230                 235                 240
Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile
                245                 250                 255
Gly Val Leu Ala Gly Met Ala Leu Ile
            260                 265

<210> 1886
<211> 84
<212> PRT
<213> Homo sapiens

<400> 1886
Glu Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu
 1               5                  10                  15
Asn Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr
            20                  25                  30
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg
        35                  40                  45
Leu Leu Leu Ser Thr Asp Asn Arg Thr Leu Leu Leu Leu Ser Ala Thr
    50                  55                  60
Lys Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly
65                  70                  75                  80
Ala Gln Pro Arg


<210> 1887
<211> 265
<212> PRT
<213> Homo sapiens

<400> 1887
Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn
            20                  25                  30
Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His
                85                  90                  95
Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn
            100                 105                 110
Val Thr His Asn Asp Ala Gly Phe Tyr Thr Leu His Val Ile Lys Glu
        115                 120                 125
Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu
    130                 135                 140
Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn
145                 150                 155                 160
Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr
                165                 170                 175
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu
            180                 185                 190
Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys
        195                 200                 205
Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala
    210                 215                 220
Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln
225                 230                 235                 240
Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile
                245                 250                 255
Gly Val Leu Ala Gly Met Ala Leu Ile
            260                 265

<210> 1888
<211> 301
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(301)
<223> Xaa = Any Amino Acid

<400> 1888
Ala Asp Ala Trp Gly Arg Thr Ala Glu Leu Thr Val Thr Ala Ala Leu
 1               5                  10                  15
Thr Arg Glu Phe Leu Glu Pro Lys Leu Phe Ser Thr Glu Asp Lys Gln
            20                  25                  30
Ala Ala Glu Thr Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys
        35                  40                  45
Ile Pro Trp Gln Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp
    50                  55                  60
Asn Leu Pro Asn Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn
65                  70                  75                  80
Val Ala Glu Gly Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln
                85                  90                  95
Asn Leu Tyr Gly Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn
            100                 105                 110
Tyr Arg Ile Ile Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro
        115                 120                 125
Gly Pro Ala His Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu
    130                 135                 140
Leu Ile Gln Asn Val Thr His Asn Asp Ala Gly Xaa Tyr Thr Leu His
145                 150                 155                 160
Val Ile Lys Glu Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr
                165                 170                 175
Val Phe Ser Glu Pro Pro Lys Pro Xaa Ile Thr Ser Asn Asn Phe Asn
            180                 185                 190
Pro Val Glu Asn Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr
        195                 200                 205
Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val
    210                 215                 220
Ser Pro Arg Leu Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu
225                 230                 235                 240
Ser Ala Thr Lys Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn
                245                 250                 255
Pro Val Gly Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr
            260                 265                 270
Glu Ser Val Gln Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val
        275                 280                 285
Ser Ile Met Ile Gly Val Leu Ala Gly Met Ala Leu Ile
    290                 295                 300

<210> 1889
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1889
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
 1               5                  10

<210> 1890
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1890
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
 1               5                  10

<210> 1891
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1891
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
 1               5                  10

<210> 1892
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1892
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
 1               5                  10

<210> 1893
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1893
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu
 1               5                  10

<210> 1894
<211> 265
<212> PRT
<213> Homo sapiens

<400> 1894
Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn
            20                  25                  30
Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His
                85                  90                  95
Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn
            100                 105                 110
Val Thr His Asn Asp Ala Gly Phe Tyr Thr Leu His Val Ile Lys Glu
        115                 120                 125
Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu
    130                 135                 140
Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn
145                 150                 155                 160
Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr
                165                 170                 175
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu
            180                 185                 190
Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys
        195                 200                 205
Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala
    210                 215                 220
Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln
225                 230                 235                 240
Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile
                245                 250                 255
Gly Val Leu Ala Gly Met Ala Leu Ile
            260                 265

<210> 1895
<211> 265
<212> PRT
<213> Homo sapiens

<400> 1895
Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln
 1               5                  10                  15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn
            20                  25                  30
Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly
    50                  55                  60
Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile
65                  70                  75                  80
Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His
                85                  90                  95
Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn
            100                 105                 110
Val Thr His Asn Asp Ala Gly Phe Tyr Thr Leu His Val Ile Lys Glu
        115                 120                 125
Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu
    130                 135                 140
Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn
145                 150                 155                 160
Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr
                165                 170                 175
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu
            180                 185                 190
Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys
        195                 200                 205
Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala
    210                 215                 220
Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln
225                 230                 235                 240
Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile
                245                 250                 255
Gly Val Leu Ala Gly Met Ala Leu Ile
            260                 265

<210> 1896
<211> 84
<212> PRT
<213> Homo sapiens

<400> 1896
Glu Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu
 1               5                  10                  15
Asn Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr
            20                  25                  30
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg
        35                  40                  45
Leu Leu Leu Ser Thr Asp Asn Arg Thr Leu Leu Leu Leu Ser Ala Thr
    50                  55                  60
Lys Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly
65                  70                  75                  80
Ala Gln Pro Arg


<210> 1897
<211> 582
<212> PRT
<213> Homo sapiens

<400> 1897
Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu Ile
 1               5                  10                  15
Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn Ser
            20                  25                  30
Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro Gln
        35                  40                  45
Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser Pro
    50                  55                  60
Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr Asp
65                  70                  75                  80
Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr Thr
                85                  90                  95
Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val Cys
            100                 105                 110
Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val Lys
        115                 120                 125
Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu Phe
    130                 135                 140
Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu Asp
145                 150                 155                 160
Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val Leu
                165                 170                 175
His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met Asp
            180                 185                 190
Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys Thr
        195                 200                 205
Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr Tyr
    210                 215                 220
Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe Asp
225                 230                 235                 240
Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro Lys
                245                 250                 255
Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly Asn
            260                 265                 270
Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln Pro
        275                 280                 285
Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg Arg
    290                 295                 300
Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser Met
305                 310                 315                 320
Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu Asn
                325                 330                 335
Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val Ser
            340                 345                 350
Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys Asp
        355                 360                 365
Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr Gln
    370                 375                 380
Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu Gly
385                 390                 395                 400
Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro Gln
                405                 410                 415
Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr Ile
            420                 425                 430
Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr Ile
        435                 440                 445
Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr Ile
    450                 455                 460
Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn Val
465                 470                 475                 480
Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn Ser
                485                 490                 495
Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp Glu
            500                 505                 510
Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu Ile
        515                 520                 525
Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly Val
    530                 535                 540
Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His Val
545                 550                 555                 560
Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu Asn
                565                 570                 575
Asn His Lys Thr Glu Ala
            580

<210> 1898
<211> 582
<212> PRT
<213> Homo sapiens

<400> 1898
Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu Ile
 1               5                  10                  15
Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn Ser
            20                  25                  30
Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro Gln
        35                  40                  45
Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser Pro
    50                  55                  60
Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr Asp
65                  70                  75                  80
Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr Thr
                85                  90                  95
Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val Cys
            100                 105                 110
Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val Lys
        115                 120                 125
Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu Phe
    130                 135                 140
Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu Asp
145                 150                 155                 160
Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val Leu
                165                 170                 175
His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met Asp
            180                 185                 190
Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys Thr
        195                 200                 205
Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr Tyr
    210                 215                 220
Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe Asp
225                 230                 235                 240
Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro Lys
                245                 250                 255
Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly Asn
            260                 265                 270
Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln Pro
        275                 280                 285
Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg Arg
    290                 295                 300
Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser Met
305                 310                 315                 320
Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu Asn
                325                 330                 335
Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val Ser
            340                 345                 350
Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys Asp
        355                 360                 365
Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr Gln
    370                 375                 380
Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu Gly
385                 390                 395                 400
Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro Gln
                405                 410                 415
Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr Ile
            420                 425                 430
Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr Ile
        435                 440                 445
Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr Ile
    450                 455                 460
Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn Val
465                 470                 475                 480
Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn Ser
                485                 490                 495
Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp Glu
            500                 505                 510
Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu Ile
        515                 520                 525
Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly Val
    530                 535                 540
Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His Val
545                 550                 555                 560
Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu Asn
                565                 570                 575
Asn His Lys Thr Glu Ala
            580

<210> 1899
<211> 583
<212> PRT
<213> Homo sapiens

<400> 1899
Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu
 1               5                  10                  15
Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn
            20                  25                  30
Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro
        35                  40                  45
Gln Asn Leu Met Phe Gly Lys Trp Asn Tyr Glu Lys Pro Asp Gly Ser
    50                  55                  60
Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr
65                  70                  75                  80
Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr
                85                  90                  95
Thr Leu Ser Ile Ser Asn Ala Arg Asn Ser Asp Glu Lys Arg Phe Val
            100                 105                 110
Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val
        115                 120                 125
Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu
    130                 135                 140
Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu
145                 150                 155                 160
Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val
                165                 170                 175
Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met
            180                 185                 190
Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys
        195                 200                 205
Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr
    210                 215                 220
Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe
225                 230                 235                 240
Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro
                245                 250                 255
Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly
            260                 265                 270
Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln
        275                 280                 285
Pro Glu Arg Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg
    290                 295                 300
Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser
305                 310                 315                 320
Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu
                325                 330                 335
Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val
            340                 345                 350
Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys
        355                 360                 365
Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr
    370                 375                 380
Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu
385                 390                 395                 400
Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro
                405                 410                 415
Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr
            420                 425                 430
Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr
        435                 440                 445
Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr
    450                 455                 460
Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn
465                 470                 475                 480
Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn
                485                 490                 495
Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp
            500                 505                 510
Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu
        515                 520                 525
Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly
    530                 535                 540
Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His
545                 550                 555                 560
Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu
                565                 570                 575
Asn Asn His Lys Thr Glu Ala
            580

<210> 1900
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1900
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Ala Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Ile Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Val Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Ser His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1901
<211> 141
<212> PRT
<213> Homo sapiens

<400> 1901
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr
    130                 135                 140

<210> 1902
<211> 321
<212> PRT
<213> Homo sapiens

<400> 1902
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Phe Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr
                165                 170                 175
Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
        195                 200                 205
Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser
                245                 250                 255
Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser
    290                 295                 300
Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Asp
305                 310                 315                 320
Asn


<210> 1903
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1903
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Ala Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Ile Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175
Val Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Ser His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335
Val Leu Ala Arg Val Ala Leu Ile
            340

<210> 1904
<211> 141
<212> PRT
<213> Homo sapiens

<400> 1904
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr
    130                 135                 140

<210> 1905
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 1905
Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro
 1               5                  10                  15
Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser
            20                  25                  30
Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu
        35                  40                  45
Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu
    50                  55                  60
Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn
65                  70                  75                  80
Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys
                85                  90                  95
Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu
            100                 105                 110
Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr
        115                 120                 125
Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln
    130                 135                 140
Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys
145                 150                 155                 160
Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp
                165                 170                 175
Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile
            180                 185                 190
Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys
        195                 200                 205
Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln
    210                 215                 220
Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys
225                 230                 235                 240
Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn
                245                 250                 255
Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile
            260                 265                 270
Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr
        275                 280                 285
Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr
    290                 295                 300
Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn
305                 310                 315                 320
Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu
                325                 330                 335
Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu
            340                 345                 350
Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp
        355                 360                 365
Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser
    370                 375                 380
Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile
385                 390                 395                 400
Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg
                405                 410                 415
Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu
            420                 425                 430
Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu
        435                 440                 445
Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu
    450                 455                 460
Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala
465                 470                 475                 480
Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro
                485                 490                 495
Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly
            500                 505                 510
Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg
        515                 520                 525
Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe
    530                 535                 540
Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr
545                 550                 555                 560
Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser
                565                 570                 575
Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn
            580                 585                 590
Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val
        595                 600                 605
Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe
    610                 615                 620
Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu
625                 630                 635                 640
Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro
                645                 650                 655
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile
            660                 665                 670
Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp
        675                 680                 685
Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val
    690                 695                 700
Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr
705                 710                 715                 720
Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr
                725                 730                 735
Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu
            740                 745                 750
Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln
        755                 760                 765
His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn
    770                 775                 780
Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu
785                 790                 795                 800
Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp
                805                 810                 815
Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met
            820                 825                 830
Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys
        835                 840                 845
Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys
    850                 855                 860
Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys
865                 870                 875                 880
Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val
                885                 890                 895
Asp Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe
            900                 905                 910
Glu Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr
        915                 920                 925
Gln Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu
    930                 935                 940
Leu Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn
945                 950                 955                 960
Ser Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His
                965                 970                 975
Cys Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn
            980                 985                 990
Leu Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val
        995                 1000                1005
Val Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu
    1010                1015                1020
Gln Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln
1025                1030                1035                1040
Asn Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe
                1045                1050                1055
Asp Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro
            1060                1065                1070
Leu Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly
        1075                1080                1085
Ser Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly
    1090                1095                1100
Pro Ala Ser Pro Ala Leu Asn Gln Gly Ser
1105                1110

<210> 1906
<211> 1143
<212> PRT
<213> Homo sapiens

<400> 1906
Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp
 1               5                  10                  15
Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Asp
            20                  25                  30
Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly Ser
        35                  40                  45
Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro Thr
    50                  55                  60
Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn Lys
65                  70                  75                  80
Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val Glu
                85                  90                  95
Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr Glu
            100                 105                 110
Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala Pro
        115                 120                 125
Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe Gln
    130                 135                 140
Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys Leu
145                 150                 155                 160
Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile Thr
                165                 170                 175
Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile Lys
            180                 185                 190
Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu Ile
        195                 200                 205
Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys Thr
    210                 215                 220
Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser Glu
225                 230                 235                 240
Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser Phe
                245                 250                 255
His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys Leu
            260                 265                 270
Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys Pro
        275                 280                 285
Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys Val
    290                 295                 300
Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser Ala
305                 310                 315                 320
Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp Asn
                325                 330                 335
Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro His
            340                 345                 350
Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg Asn
        355                 360                 365
Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr Ser
    370                 375                 380
Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro Gly
385                 390                 395                 400
Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala Leu
                405                 410                 415
Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu Leu
            420                 425                 430
Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys Asn
        435                 440                 445
Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln Leu
    450                 455                 460
Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr Lys
465                 470                 475                 480
Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln Ser
                485                 490                 495
Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys Pro
            500                 505                 510
Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp Tyr
        515                 520                 525
Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn Tyr
    530                 535                 540
Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr Ile
545                 550                 555                 560
Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg Met
                565                 570                 575
Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys Glu
            580                 585                 590
Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu Glu
        595                 600                 605
Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His Lys
    610                 615                 620
Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys Lys
625                 630                 635                 640
Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser Trp
                645                 650                 655
Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu Arg
            660                 665                 670
Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val Val
        675                 680                 685
His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile Asp
    690                 695                 700
Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr Gly
705                 710                 715                 720
Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val Glu
                725                 730                 735
Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln Phe
            740                 745                 750
Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His Asn
        755                 760                 765
Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala Glu
    770                 775                 780
Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile Gly
785                 790                 795                 800
Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile Pro
                805                 810                 815
Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser Lys
            820                 825                 830
Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp Ser
        835                 840                 845
Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr Trp
    850                 855                 860
Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr Ile
865                 870                 875                 880
Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile Val
                885                 890                 895
Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln Tyr
            900                 905                 910
Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu Lys
        915                 920                 925
Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu Arg
    930                 935                 940
His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr Thr
945                 950                 955                 960
Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile Ser
                965                 970                 975
Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser Glu
            980                 985                 990
Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg Asp
        995                 1000                1005
Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu Glu
    1010                1015                1020
Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys Ala
1025                1030                1035                1040
Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr Gln
                1045                1050                1055
Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly Gln
            1060                1065                1070
Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn Glu
        1075                1080                1085
Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly Ala
    1090                1095                1100
Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu Pro
1105                1110                1115                1120
Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala Ser
                1125                1130                1135
Pro Ala Leu Asn Gln Gly Ser
            1140

<210> 1907
<211> 1304
<212> PRT
<213> Homo sapiens

<400> 1907
Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp
 1               5                  10                  15
Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Gly
            20                  25                  30
Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro Leu
        35                  40                  45
Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg Glu
    50                  55                  60
Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr Ser
65                  70                  75                  80
Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn Thr
                85                  90                  95
Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp
            100                 105                 110
Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser
        115                 120                 125
Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser
    130                 135                 140
Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro
145                 150                 155                 160
Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala
                165                 170                 175
Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser
            180                 185                 190
Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly
        195                 200                 205
Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro
    210                 215                 220
Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn
225                 230                 235                 240
Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val
                245                 250                 255
Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr
            260                 265                 270
Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala
        275                 280                 285
Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe
    290                 295                 300
Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys
305                 310                 315                 320
Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile
                325                 330                 335
Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile
            340                 345                 350
Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu
        355                 360                 365
Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys
    370                 375                 380
Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser
385                 390                 395                 400
Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser
                405                 410                 415
Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys
            420                 425                 430
Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys
        435                 440                 445
Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys
    450                 455                 460
Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser
465                 470                 475                 480
Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp
                485                 490                 495
Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro
            500                 505                 510
His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg
        515                 520                 525
Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr
    530                 535                 540
Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro
545                 550                 555                 560
Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala
                565                 570                 575
Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu
            580                 585                 590
Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys
        595                 600                 605
Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln
    610                 615                 620
Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr
625                 630                 635                 640
Lys Arg Lys Ile Ala Asp Glu Gly Arg Pro Phe Leu Ala Glu Phe Gln
                645                 650                 655
Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys
            660                 665                 670
Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp
        675                 680                 685
Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn
    690                 695                 700
Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr
705                 710                 715                 720
Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg
                725                 730                 735
Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys
            740                 745                 750
Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu
        755                 760                 765
Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His
    770                 775                 780
Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys
785                 790                 795                 800
Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser
                805                 810                 815
Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu
            820                 825                 830
Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val
        835                 840                 845
Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile
    850                 855                 860
Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr
865                 870                 875                 880
Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val
                885                 890                 895
Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln
            900                 905                 910
Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His
        915                 920                 925
Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala
    930                 935                 940
Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile
945                 950                 955                 960
Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile
                965                 970                 975
Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser
            980                 985                 990
Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp
        995                 1000                1005
Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr
    1010                1015                1020
Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr
1025                1030                1035                1040
Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile
                1045                1050                1055
Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln
            1060                1065                1070
Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu
        1075                1080                1085
Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu
    1090                1095                1100
Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr
1105                1110                1115                1120
Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile
                1125                1130                1135
Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser
            1140                1145                1150
Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg
        1155                1160                1165
Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu
    1170                1175                1180
Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys
1185                1190                1195                1200
Ala Leu Arg Lys Ala Arg Leu Gly Met Val Ser Thr Phe Glu Gln Tyr
                1205                1210                1215
Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly
            1220                1225                1230
Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn
        1235                1240                1245
Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly
    1250                1255                1260
Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu
1265                1270                1275                1280
Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala
                1285                1290                1295
Ser Pro Ala Leu Asn Gln Gly Ser
            1300

<210> 1908
<211> 1149
<212> PRT
<213> Homo sapiens

<400> 1908
Leu Pro Asp Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly
 1               5                  10                  15
Phe Ala Phe Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr
            20                  25                  30
Pro Ser Pro Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu
        35                  40                  45
Ser Pro Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr
    50                  55                  60
Pro Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp
65                  70                  75                  80
Tyr Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val
                85                  90                  95
Asn Glu Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val
            100                 105                 110
His Asn Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn
        115                 120                 125
Ser Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly
    130                 135                 140
Val Glu Lys Val Pro Val His Cys Cys Ser Gln Val Glu Gln Pro Asp
145                 150                 155                 160
Ser Thr Ile Trp Leu Lys Trp Lys Asn Ile Glu Thr Ser Thr Cys Asp
                165                 170                 175
Thr Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp
            180                 185                 190
Asn Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys
        195                 200                 205
Cys Asp Ser Glu Ile Leu Tyr Asn Ser His Lys Phe Thr Asn Ala Ser
    210                 215                 220
Lys Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile
225                 230                 235                 240
Phe Cys Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro
                245                 250                 255
Pro Gln Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr
            260                 265                 270
Glu Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu
        275                 280                 285
Gln Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr
    290                 295                 300
Ile Ile Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe
305                 310                 315                 320
Thr Thr Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser
                325                 330                 335
Met Thr Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp
            340                 345                 350
Arg Asn Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn
        355                 360                 365
Thr Leu Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys
    370                 375                 380
Asp Leu Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn
385                 390                 395                 400
Gly Asp Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr
                405                 410                 415
Asn Ser Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr
            420                 425                 430
Ser Ile Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys
        435                 440                 445
Lys Arg Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp
    450                 455                 460
Asp Glu Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu
465                 470                 475                 480
Leu Glu Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu
                485                 490                 495
Ala Glu Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys
            500                 505                 510
Glu Ala Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile
        515                 520                 525
Leu Pro Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp
    530                 535                 540
Ala Gly Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu
545                 550                 555                 560
Pro Arg Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp
                565                 570                 575
Asp Phe Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met
            580                 585                 590
Val Thr Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp
        595                 600                 605
Pro Ser Met Glu Glu Gly Thr Arg Ala Phe Gly Glu Cys Cys Cys Lys
    610                 615                 620
Asp Leu Thr Lys His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu
625                 630                 635                 640
Asn Ile Val Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His
                645                 650                 655
Ile Gln Phe Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His
            660                 665                 670
Leu Leu Leu Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe
        675                 680                 685
Ser Gly Pro Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly
    690                 695                 700
Thr Tyr Ile Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn
705                 710                 715                 720
Lys Val Asp Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys
                725                 730                 735
Leu Met Val Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu
            740                 745                 750
Val Glu Tyr Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu
        755                 760                 765
His Pro Tyr Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro
    770                 775                 780
Ser Pro Leu Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp
785                 790                 795                 800
Arg Thr Gln His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg
                805                 810                 815
Asn Ser Asn Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His
            820                 825                 830
Glu Leu Glu Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser
        835                 840                 845
Asp Asp Asp Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser
    850                 855                 860
Phe Ile Met Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly
865                 870                 875                 880
Pro Leu Lys Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg
                885                 890                 895
Lys Val Lys Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln
            900                 905                 910
Glu Ile Cys Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp
        915                 920                 925
Ile Glu Val Asp Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu
    930                 935                 940
Arg Val Phe Glu Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val
945                 950                 955                 960
Tyr Gln Tyr Gln Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu
                965                 970                 975
Pro Lys Glu Leu Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro
            980                 985                 990
Gln Lys Asn Ser Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu
        995                 1000                1005
Leu Ile His Cys Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala
    1010                1015                1020
Leu Leu Asn Leu Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile
1025                1030                1035                1040
Phe Gln Val Val Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser
                1045                1050                1055
Thr Phe Glu Gln Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr
            1060                1065                1070
Pro Ala Gln Asn Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys
        1075                1080                1085
Ile Glu Phe Asp Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys
    1090                1095                1100
Val Asn Pro Leu Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln
1105                1110                1115                1120
Ala Glu Gly Ser Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser
                1125                1130                1135
Val Asn Gly Pro Ala Ser Pro Ala Leu Asn Gln Gly Ser
            1140                1145

<210> 1909
<211> 1304
<212> PRT
<213> Homo sapiens

<400> 1909
Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp
 1               5                  10                  15
Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Gly
            20                  25                  30
Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro Leu
        35                  40                  45
Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg Glu
    50                  55                  60
Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr Ser
65                  70                  75                  80
Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn Thr
                85                  90                  95
Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp
            100                 105                 110
Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser
        115                 120                 125
Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser
    130                 135                 140
Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro
145                 150                 155                 160
Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala
                165                 170                 175
Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser
            180                 185                 190
Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly
        195                 200                 205
Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro
    210                 215                 220
Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn
225                 230                 235                 240
Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val
                245                 250                 255
Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr
            260                 265                 270
Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala
        275                 280                 285
Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe
    290                 295                 300
Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys
305                 310                 315                 320
Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile
                325                 330                 335
Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile
            340                 345                 350
Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu
        355                 360                 365
Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys
    370                 375                 380
Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser
385                 390                 395                 400
Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser
                405                 410                 415
Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys
            420                 425                 430
Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys
        435                 440                 445
Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys
    450                 455                 460
Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser
465                 470                 475                 480
Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp
                485                 490                 495
Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro
            500                 505                 510
His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg
        515                 520                 525
Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr
    530                 535                 540
Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro
545                 550                 555                 560
Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala
                565                 570                 575
Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu
            580                 585                 590
Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys
        595                 600                 605
Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln
    610                 615                 620
Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr
625                 630                 635                 640
Lys Arg Lys Ile Ala Asp Glu Gly Arg Pro Phe Leu Ala Glu Phe Gln
                645                 650                 655
Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys
            660                 665                 670
Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp
        675                 680                 685
Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn
    690                 695                 700
Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr
705                 710                 715                 720
Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg
                725                 730                 735
Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys
            740                 745                 750
Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu
        755                 760                 765
Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His
    770                 775                 780
Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys
785                 790                 795                 800
Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser
                805                 810                 815
Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu
            820                 825                 830
Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val
        835                 840                 845
Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile
    850                 855                 860
Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr
865                 870                 875                 880
Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val
                885                 890                 895
Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln
            900                 905                 910
Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His
        915                 920                 925
Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala
    930                 935                 940
Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile
945                 950                 955                 960
Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile
                965                 970                 975
Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser
            980                 985                 990
Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp
        995                 1000                1005
Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr
    1010                1015                1020
Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr
1025                1030                1035                1040
Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile
                1045                1050                1055
Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln
            1060                1065                1070
Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu
        1075                1080                1085
Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu
    1090                1095                1100
Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr
1105                1110                1115                1120
Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile
                1125                1130                1135
Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser
            1140                1145                1150
Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg
        1155                1160                1165
Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu
    1170                1175                1180
Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys
1185                1190                1195                1200
Ala Leu Arg Lys Ala Arg Leu Gly Met Val Ser Thr Phe Glu Gln Tyr
                1205                1210                1215
Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly
            1220                1225                1230
Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn
        1235                1240                1245
Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly
    1250                1255                1260
Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu
1265                1270                1275                1280
Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala
                1285                1290                1295
Ser Pro Ala Leu Asn Gln Gly Ser
            1300

<210> 1910
<211> 1304
<212> PRT
<213> Homo sapiens

<400> 1910
Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp
 1               5                  10                  15
Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Gly
            20                  25                  30
Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro Leu
        35                  40                  45
Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg Glu
    50                  55                  60
Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr Ser
65                  70                  75                  80
Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn Thr
                85                  90                  95
Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp
            100                 105                 110
Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser
        115                 120                 125
Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser
    130                 135                 140
Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro
145                 150                 155                 160
Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala
                165                 170                 175
Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser
            180                 185                 190
Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly
        195                 200                 205
Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro
    210                 215                 220
Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn
225                 230                 235                 240
Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val
                245                 250                 255
Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr
            260                 265                 270
Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala
        275                 280                 285
Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe
    290                 295                 300
Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys
305                 310                 315                 320
Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile
                325                 330                 335
Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile
            340                 345                 350
Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu
        355                 360                 365
Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys
    370                 375                 380
Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser
385                 390                 395                 400
Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser
                405                 410                 415
Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys
            420                 425                 430
Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys
        435                 440                 445
Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys
    450                 455                 460
Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser
465                 470                 475                 480
Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp
                485                 490                 495
Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro
            500                 505                 510
His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg
        515                 520                 525
Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr
    530                 535                 540
Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro
545                 550                 555                 560
Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala
                565                 570                 575
Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu
            580                 585                 590
Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys
        595                 600                 605
Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln
    610                 615                 620
Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr
625                 630                 635                 640
Lys Arg Lys Ile Ala Asp Glu Gly Arg Pro Phe Leu Ala Glu Phe Gln
                645                 650                 655
Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys
            660                 665                 670
Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp
        675                 680                 685
Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn
    690                 695                 700
Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr
705                 710                 715                 720
Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg
                725                 730                 735
Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys
            740                 745                 750
Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu
        755                 760                 765
Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His
    770                 775                 780
Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys
785                 790                 795                 800
Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser
                805                 810                 815
Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu
            820                 825                 830
Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val
        835                 840                 845
Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile
    850                 855                 860
Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr
865                 870                 875                 880
Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val
                885                 890                 895
Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln
            900                 905                 910
Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His
        915                 920                 925
Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala
    930                 935                 940
Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile
945                 950                 955                 960
Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile
                965                 970                 975
Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser
            980                 985                 990
Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp
        995                 1000                1005
Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr
    1010                1015                1020
Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr
1025                1030                1035                1040
Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile
                1045                1050                1055
Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln
            1060                1065                1070
Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu
        1075                1080                1085
Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu
    1090                1095                1100
Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr
1105                1110                1115                1120
Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile
                1125                1130                1135
Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser
            1140                1145                1150
Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg
        1155                1160                1165
Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu
    1170                1175                1180
Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys
1185                1190                1195                1200
Ala Leu Arg Lys Ala Arg Leu Gly Met Val Ser Thr Phe Glu Gln Tyr
                1205                1210                1215
Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly
            1220                1225                1230
Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn
        1235                1240                1245
Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly
    1250                1255                1260
Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu
1265                1270                1275                1280
Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala
                1285                1290                1295
Ser Pro Ala Leu Asn Gln Gly Ser
            1300

<210> 1911
<211> 1143
<212> PRT
<213> Homo sapiens

<400> 1911
Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp
 1               5                  10                  15
Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Asp
            20                  25                  30
Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly Ser
        35                  40                  45
Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro Thr
    50                  55                  60
Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn Lys
65                  70                  75                  80
Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val Glu
                85                  90                  95
Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr Glu
            100                 105                 110
Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala Pro
        115                 120                 125
Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe Gln
    130                 135                 140
Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys Leu
145                 150                 155                 160
Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile Thr
                165                 170                 175
Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile Lys
            180                 185                 190
Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu Ile
        195                 200                 205
Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys Thr
    210                 215                 220
Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser Glu
225                 230                 235                 240
Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser Phe
                245                 250                 255
His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys Leu
            260                 265                 270
Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys Pro
        275                 280                 285
Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys Val
    290                 295                 300
Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser Ala
305                 310                 315                 320
Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp Asn
                325                 330                 335
Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro His
            340                 345                 350
Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg Asn
        355                 360                 365
Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr Ser
    370                 375                 380
Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro Gly
385                 390                 395                 400
Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala Leu
                405                 410                 415
Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu Leu
            420                 425                 430
Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys Asn
        435                 440                 445
Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln Leu
    450                 455                 460
Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr Lys
465                 470                 475                 480
Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln Ser
                485                 490                 495
Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys Pro
            500                 505                 510
Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp Tyr
        515                 520                 525
Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn Tyr
    530                 535                 540
Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr Ile
545                 550                 555                 560
Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg Met
                565                 570                 575
Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys Glu
            580                 585                 590
Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu Glu
        595                 600                 605
Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His Lys
    610                 615                 620
Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys Lys
625                 630                 635                 640
Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser Trp
                645                 650                 655
Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu Arg
            660                 665                 670
Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val Val
        675                 680                 685
His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile Asp
    690                 695                 700
Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr Gly
705                 710                 715                 720
Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val Glu
                725                 730                 735
Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln Phe
            740                 745                 750
Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His Asn
        755                 760                 765
Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala Glu
    770                 775                 780
Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile Gly
785                 790                 795                 800
Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile Pro
                805                 810                 815
Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser Lys
            820                 825                 830
Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp Ser
        835                 840                 845
Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr Trp
    850                 855                 860
Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr Ile
865                 870                 875                 880
Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile Val
                885                 890                 895
Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln Tyr
            900                 905                 910
Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu Lys
        915                 920                 925
Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu Arg
    930                 935                 940
His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr Thr
945                 950                 955                 960
Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile Ser
                965                 970                 975
Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser Glu
            980                 985                 990
Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg Asp
        995                 1000                1005
Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu Glu
    1010                1015                1020
Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys Ala
1025                1030                1035                1040
Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr Gln
                1045                1050                1055
Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly Gln
            1060                1065                1070
Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn Glu
        1075                1080                1085
Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly Ala
    1090                1095                1100
Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu Pro
1105                1110                1115                1120
Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala Ser
                1125                1130                1135
Pro Ala Leu Asn Gln Gly Ser
            1140

<210> 1912
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 1912
Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro
 1               5                  10                  15
Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser
            20                  25                  30
Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu
        35                  40                  45
Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu
    50                  55                  60
Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn
65                  70                  75                  80
Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys
                85                  90                  95
Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu
            100                 105                 110
Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr
        115                 120                 125
Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln
    130                 135                 140
Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys
145                 150                 155                 160
Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp
                165                 170                 175
Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile
            180                 185                 190
Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys
        195                 200                 205
Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln
    210                 215                 220
Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys
225                 230                 235                 240
Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn
                245                 250                 255
Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile
            260                 265                 270
Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr
        275                 280                 285
Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr
    290                 295                 300
Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn
305                 310                 315                 320
Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu
                325                 330                 335
Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu
            340                 345                 350
Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp
        355                 360                 365
Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser
    370                 375                 380
Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile
385                 390                 395                 400
Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg
                405                 410                 415
Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu
            420                 425                 430
Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu
        435                 440                 445
Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu
    450                 455                 460
Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala
465                 470                 475                 480
Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro
                485                 490                 495
Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly
            500                 505                 510
Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg
        515                 520                 525
Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe
    530                 535                 540
Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr
545                 550                 555                 560
Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser
                565                 570                 575
Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn
            580                 585                 590
Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val
        595                 600                 605
Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe
    610                 615                 620
Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu
625                 630                 635                 640
Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro
                645                 650                 655
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile
            660                 665                 670
Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp
        675                 680                 685
Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val
    690                 695                 700
Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr
705                 710                 715                 720
Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr
                725                 730                 735
Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu
            740                 745                 750
Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln
        755                 760                 765
His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn
    770                 775                 780
Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu
785                 790                 795                 800
Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp
                805                 810                 815
Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met
            820                 825                 830
Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys
        835                 840                 845
Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys
    850                 855                 860
Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys
865                 870                 875                 880
Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val
                885                 890                 895
Asp Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe
            900                 905                 910
Glu Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr
        915                 920                 925
Gln Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu
    930                 935                 940
Leu Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn
945                 950                 955                 960
Ser Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His
                965                 970                 975
Cys Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn
            980                 985                 990
Leu Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val
        995                 1000                1005
Val Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu
    1010                1015                1020
Gln Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln
1025                1030                1035                1040
Asn Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe
                1045                1050                1055
Asp Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro
            1060                1065                1070
Leu Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly
        1075                1080                1085
Ser Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly
    1090                1095                1100
Pro Ala Ser Pro Ala Leu Asn Gln Gly Ser
1105                1110

<210> 1913
<211> 694
<212> PRT
<213> Homo sapiens

<400> 1913
Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu
 1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu
            20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser
        35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr
    50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys
65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val
                85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln
            100                 105                 110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu
        115                 120                 125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly
    130                 135                 140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys
145                 150                 155                 160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser
                165                 170                 175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu
            180                 185                 190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu
        195                 200                 205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr
    210                 215                 220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly
225                 230                 235                 240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp
                245                 250                 255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe
            260                 265                 270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro
        275                 280                 285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr
    290                 295                 300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln
305                 310                 315                 320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His
                325                 330                 335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr
            340                 345                 350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala
        355                 360                 365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu
    370                 375                 380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp
385                 390                 395                 400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp
                405                 410                 415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys
            420                 425                 430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys
        435                 440                 445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser
    450                 455                 460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn
465                 470                 475                 480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu
                485                 490                 495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val
            500                 505                 510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu
        515                 520                 525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly
    530                 535                 540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn
545                 550                 555                 560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly
                565                 570                 575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala
            580                 585                 590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser
        595                 600                 605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu
    610                 615                 620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys
625                 630                 635                 640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile
                645                 650                 655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile
            660                 665                 670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser
        675                 680                 685
Ile Leu Val His Cys Val
    690

<210> 1914
<211> 681
<212> PRT
<213> Homo sapiens

<400> 1914
Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu Glu
 1               5                  10                  15
Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser Asn
            20                  25                  30
Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr His
        35                  40                  45
Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys Leu
    50                  55                  60
Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val Val
65                  70                  75                  80
Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln Asp
                85                  90                  95
Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu Ala
            100                 105                 110
His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly Ala
        115                 120                 125
Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys Asp
    130                 135                 140
Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser Arg
145                 150                 155                 160
Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu Glu
                165                 170                 175
Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu Val
            180                 185                 190
His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr Cys
        195                 200                 205
Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly Arg
    210                 215                 220
Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp Arg
225                 230                 235                 240
Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe Lys
                245                 250                 255
Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro Gln
            260                 265                 270
Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr Pro
        275                 280                 285
Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln Phe
    290                 295                 300
Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His Leu
305                 310                 315                 320
Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr Val
                325                 330                 335
Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala Tyr
            340                 345                 350
Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu Thr
        355                 360                 365
Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp Leu
    370                 375                 380
Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp Pro
385                 390                 395                 400
Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys Tyr
                405                 410                 415
Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys Met
            420                 425                 430
Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser Lys
        435                 440                 445
Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn Ser
    450                 455                 460
Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu Asn
465                 470                 475                 480
Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val Gln
                485                 490                 495
Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu Thr
            500                 505                 510
Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly Val
        515                 520                 525
Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn Ala
    530                 535                 540
Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly Lys
545                 550                 555                 560
Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala Cys
                565                 570                 575
Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser Gly
            580                 585                 590
Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu Arg
        595                 600                 605
Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys Cys
    610                 615                 620
Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile Asp
625                 630                 635                 640
Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile Val
                645                 650                 655
Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser Ile
            660                 665                 670
Leu Val His Cys Val Thr Ser Lys Cys
        675                 680

<210> 1915
<211> 681
<212> PRT
<213> Homo sapiens

<400> 1915
Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu Glu
 1               5                  10                  15
Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser Asn
            20                  25                  30
Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr His
        35                  40                  45
Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys Leu
    50                  55                  60
Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val Val
65                  70                  75                  80
Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln Asp
                85                  90                  95
Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu Ala
            100                 105                 110
His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly Ala
        115                 120                 125
Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys Asp
    130                 135                 140
Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser Arg
145                 150                 155                 160
Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu Glu
                165                 170                 175
Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu Val
            180                 185                 190
His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr Cys
        195                 200                 205
Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly Arg
    210                 215                 220
Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp Arg
225                 230                 235                 240
Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe Lys
                245                 250                 255
Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro Gln
            260                 265                 270
Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr Pro
        275                 280                 285
Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln Phe
    290                 295                 300
Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His Leu
305                 310                 315                 320
Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr Val
                325                 330                 335
Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala Tyr
            340                 345                 350
Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu Thr
        355                 360                 365
Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp Leu
    370                 375                 380
Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp Pro
385                 390                 395                 400
Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys Tyr
                405                 410                 415
Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys Met
            420                 425                 430
Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser Lys
        435                 440                 445
Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn Ser
    450                 455                 460
Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu Asn
465                 470                 475                 480
Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val Gln
                485                 490                 495
Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu Thr
            500                 505                 510
Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly Val
        515                 520                 525
Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn Ala
    530                 535                 540
Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly Lys
545                 550                 555                 560
Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala Cys
                565                 570                 575
Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser Gly
            580                 585                 590
Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu Arg
        595                 600                 605
Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys Cys
    610                 615                 620
Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile Asp
625                 630                 635                 640
Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile Val
                645                 650                 655
Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser Ile
            660                 665                 670
Leu Val His Cys Val Thr Ser Lys Cys
        675                 680

<210> 1916
<211> 694
<212> PRT
<213> Homo sapiens

<400> 1916
Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu
 1               5                  10                  15
Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu
            20                  25                  30
Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser
        35                  40                  45
Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr
    50                  55                  60
His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys
65                  70                  75                  80
Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val
                85                  90                  95
Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln
            100                 105                 110
Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu
        115                 120                 125
Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly
    130                 135                 140
Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys
145                 150                 155                 160
Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser
                165                 170                 175
Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu
            180                 185                 190
Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu
        195                 200                 205
Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr
    210                 215                 220
Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly
225                 230                 235                 240
Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp
                245                 250                 255
Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe
            260                 265                 270
Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro
        275                 280                 285
Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr
    290                 295                 300
Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln
305                 310                 315                 320
Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His
                325                 330                 335
Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr
            340                 345                 350
Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala
        355                 360                 365
Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu
    370                 375                 380
Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp
385                 390                 395                 400
Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp
                405                 410                 415
Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys
            420                 425                 430
Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys
        435                 440                 445
Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser
    450                 455                 460
Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn
465                 470                 475                 480
Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu
                485                 490                 495
Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val
            500                 505                 510
Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu
        515                 520                 525
Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly
    530                 535                 540
Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn
545                 550                 555                 560
Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly
                565                 570                 575
Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala
            580                 585                 590
Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser
        595                 600                 605
Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu
    610                 615                 620
Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys
625                 630                 635                 640
Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile
                645                 650                 655
Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile
            660                 665                 670
Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser
        675                 680                 685
Ile Leu Val His Cys Val
    690

<210> 1917
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1917
Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro
 1               5                  10                  15
Tyr Ala Ala


<210> 1918
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1918
Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro
 1               5                  10                  15
Tyr Ala Ala


<210> 1919
<211> 141
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(141)
<223> Xaa = Any Amino Acid

<400> 1919
Glu Pro Xaa Asn Pro Ser Glu Lys Asn Ser Pro Ser Thr Gln Tyr Cys
 1               5                  10                  15
Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile Leu Ser Val Met Leu Ile
            20                  25                  30
Phe Ala Phe Phe Gln Glu Leu Val Ile Ala Gly Ile Val Glu Asn Glu
        35                  40                  45
Trp Lys Xaa Xaa Cys Ser Xaa Pro Lys Ser Asn Ile Val Leu Leu Ser
    50                  55                  60
Xaa Glu Glu Lys Lys Glu Gln Thr Ile Glu Ile Lys Glu Glu Val Val
65                  70                  75                  80
Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn Glu Glu Asp Ile Glu
                85                  90                  95
Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu Glu Thr Glu Thr Asn Phe
            100                 105                 110
Xaa Glu Pro Pro Gln Asp Gln Glu Ser Ser Pro Ile Glu Asn Asp Ser
        115                 120                 125
Ser Pro Xaa Val Ile Ser Ser Xaa Phe Xaa Xaa Leu Phe
    130                 135                 140

<210> 1920
<211> 146
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(146)
<223> Xaa = Any Amino Acid

<400> 1920
Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro Tyr Ile Asn
 1               5                  10                  15
Ile Tyr Asn Cys Glu Pro Pro Asn Pro Ser Glu Lys Asn Ser Pro Ser
            20                  25                  30
Thr Gln Tyr Xaa Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile Leu Ser
        35                  40                  45
Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile Xaa Gly Ile
    50                  55                  60
Val Asp Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys Ser Asn Ile
65                  70                  75                  80
Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Xaa Thr Ile Glu Ile Lys
                85                  90                  95
Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn Glu
            100                 105                 110
Glu Xaa Ile Glu Ile Ile Pro Xaa Gln Glu Glu Glu Glu Glu Arg Asn
        115                 120                 125
Xaa Arg Arg Thr Phe Gln Asn Xaa Pro Arg Ser Gly Ile Leu Thr Asn
    130                 135                 140
Arg Lys
145

<210> 1921
<211> 71
<212> PRT
<213> Homo sapiens

<400> 1921
His Ser Ser Pro Val Ser Arg Arg Lys Lys Glu Gln Thr Ile Glu Ile
 1               5                  10                  15
Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn
            20                  25                  30
Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu Glu
        35                  40                  45
Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser Ser Pro
    50                  55                  60
Ile Glu Asn Asp Ser Ser Pro
65                  70

<210> 1922
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1922
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240
Val Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1923
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1923
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240
Val Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1924
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1924
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1925
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1925
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Met
225                 230                 235                 240
Val Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1926
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1926
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1927
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1927
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1928
<211> 417
<212> PRT
<213> Homo sapiens

<400> 1928
Met Gly Arg Arg Arg Ala Pro Glu Leu Tyr Arg Ala Pro Phe Pro Leu
 1               5                  10                  15
Tyr Ala Leu Gln Val Asp Pro Ser Thr Gly Leu Leu Ile Ala Ala Gly
            20                  25                  30
Gly Gly Gly Ala Ala Lys Thr Gly Ile Lys Asn Gly Val His Phe Leu
        35                  40                  45
Gln Leu Glu Leu Ile Asn Gly Arg Leu Ser Ala Ser Leu Leu His Ser
    50                  55                  60
His Asp Thr Glu Thr Arg Ala Thr Met Asn Leu Ala Leu Ala Gly Asp
65                  70                  75                  80
Ile Leu Ala Ala Gly Gln Asp Ala His Cys Gln Leu Leu Arg Phe Gln
                85                  90                  95
Ala His Gln Gln Gln Gly Asn Lys Ala Glu Lys Ala Gly Ser Lys Glu
            100                 105                 110
Gln Gly Pro Arg Gln Arg Lys Gly Ala Ala Pro Ala Glu Lys Lys Cys
        115                 120                 125
Gly Ala Glu Thr Gln His Glu Gly Leu Glu Leu Arg Val Glu Asn Leu
    130                 135                 140
Gln Ala Val Gln Thr Asp Phe Ser Ser Asp Pro Leu Gln Lys Val Val
145                 150                 155                 160
Cys Phe Asn His Asp Asn Thr Leu Leu Ala Thr Gly Gly Thr Asp Gly
                165                 170                 175
Tyr Val Arg Val Trp Lys Val Pro Ser Leu Glu Lys Val Leu Glu Phe
            180                 185                 190
Lys Ala His Glu Gly Glu Ile Glu Asp Leu Ala Leu Gly Pro Asp Gly
        195                 200                 205
Lys Leu Val Thr Val Gly Arg Asp Leu Lys Ala Ser Val Trp Gln Lys
    210                 215                 220
Asp Gln Leu Val Thr Gln Leu His Trp Gln Glu Asn Gly Pro Thr Phe
225                 230                 235                 240
Ser Ser Thr Pro Tyr Arg Tyr Gln Ala Cys Arg Phe Gly Gln Val Pro
                245                 250                 255
Asp Gln Pro Ala Gly Leu Arg Leu Phe Thr Val Gln Ile Pro His Lys
            260                 265                 270
Arg Leu Arg Gln Pro Pro Pro Cys Tyr Leu Thr Ala Trp Asp Gly Ser
        275                 280                 285
Asn Phe Leu Pro Leu Arg Thr Lys Ser Cys Gly His Glu Val Val Ser
    290                 295                 300
Cys Leu Asp Val Ser Glu Ser Gly Thr Phe Leu Gly Leu Gly Thr Val
305                 310                 315                 320
Thr Gly Ser Val Ala Ile Tyr Ile Ala Phe Ser Leu Gln Cys Leu Tyr
                325                 330                 335
Tyr Val Arg Glu Ala His Gly Ile Val Val Thr Asp Val Ala Phe Leu
            340                 345                 350
Pro Glu Lys Gly Arg Gly Pro Glu Leu Leu Gly Ser His Glu Thr Ala
        355                 360                 365
Leu Phe Ser Val Ala Val Asp Ser Arg Cys Gln Leu His Leu Leu Pro
    370                 375                 380
Ser Arg Arg Ser Val Pro Val Trp Leu Leu Leu Leu Leu Cys Val Gly
385                 390                 395                 400
Leu Ile Ile Val Thr Ile Leu Leu Leu Gln Ser Ala Phe Pro Gly Phe
                405                 410                 415
Leu


<210> 1929
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1929
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1930
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1930
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1931
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1931
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1932
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1932
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265

<210> 1933
<211> 190
<212> PRT
<213> Homo sapiens

<400> 1933
Lys Cys Ser Arg Gly Ala Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr
 1               5                  10                  15
Leu Leu Leu Ala Gly Gln Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln
            20                  25                  30
Gln Gly Arg Leu Asp Lys Leu Thr Val Thr Ser Gln Asn Leu Gln Leu
        35                  40                  45
Glu Asn Leu Arg Met Lys Leu Pro Lys Pro Pro Lys Pro Val Ser Lys
    50                  55                  60
Met Arg Met Ala Thr Pro Leu Leu Met Gln Ala Leu Pro Met Gly Ala
65                  70                  75                  80
Leu Pro Gln Gly Pro Met Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr
                85                  90                  95
Glu Asp His Val Met His Leu Leu Gln Asn Ala Asp Pro Leu Lys Val
            100                 105                 110
Tyr Pro Pro Leu Lys Gly Ser Phe Pro Glu Asn Leu Thr His Leu Lys
        115                 120                 125
Asn Thr Met Glu Thr Ile Asp Trp Lys Val Phe Glu Ser Trp Met His
    130                 135                 140
His Trp Leu Leu Phe Glu Met Ser Arg His Ser Leu Glu Gln Lys Pro
145                 150                 155                 160
Thr Asp Ala Pro Pro Lys Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser
                165                 170                 175
Gly Leu Gly Val Thr Lys Gln Asp Leu Gly Pro Val Pro Met
            180                 185                 190

<210> 1934
<211> 232
<212> PRT
<213> Homo sapiens

<400> 1934
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
    210                 215                 220
Gln Asp Leu Gly Pro Val Pro Met
225                 230

<210> 1935
<211> 216
<212> PRT
<213> Homo sapiens

<400> 1935
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
 1               5                  10                  15
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
            20                  25                  30
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
        35                  40                  45
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
    50                  55                  60
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
65                  70                  75                  80
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
                85                  90                  95
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
            100                 105                 110
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
        115                 120                 125
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
    130                 135                 140
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
145                 150                 155                 160
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
                165                 170                 175
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
            180                 185                 190
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
        195                 200                 205
Gln Asp Leu Gly Pro Val Pro Met
    210                 215

<210> 1936
<211> 232
<212> PRT
<213> Homo sapiens

<400> 1936
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
    210                 215                 220
Gln Asp Leu Gly Pro Val Pro Met
225                 230

<210> 1937
<211> 216
<212> PRT
<213> Homo sapiens

<400> 1937
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
 1               5                  10                  15
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
            20                  25                  30
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
        35                  40                  45
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
    50                  55                  60
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
65                  70                  75                  80
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
                85                  90                  95
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
            100                 105                 110
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
        115                 120                 125
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
    130                 135                 140
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
145                 150                 155                 160
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
                165                 170                 175
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
            180                 185                 190
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
        195                 200                 205
Gln Asp Leu Gly Pro Val Pro Met
    210                 215

<210> 1938
<211> 232
<212> PRT
<213> Homo sapiens

<400> 1938
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
    210                 215                 220
Gln Asp Leu Gly Pro Val Pro Met
225                 230

<210> 1939
<211> 216
<212> PRT
<213> Homo sapiens

<400> 1939
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
 1               5                  10                  15
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
            20                  25                  30
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
        35                  40                  45
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
    50                  55                  60
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
65                  70                  75                  80
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
                85                  90                  95
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
            100                 105                 110
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
        115                 120                 125
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
    130                 135                 140
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Leu
145                 150                 155                 160
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
                165                 170                 175
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
            180                 185                 190
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
        195                 200                 205
Gln Asp Leu Gly Pro Val Pro Met
    210                 215

<210> 1940
<211> 296
<212> PRT
<213> Homo sapiens

<400> 1940
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160
Ser Phe Pro Glu Asn Leu Thr His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His
    210                 215                 220
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro
225                 230                 235                 240
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn
                245                 250                 255
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser
            260                 265                 270
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
        275                 280                 285
Gln Asp Leu Gly Pro Val Pro Met
    290                 295

<210> 1941
<211> 232
<212> PRT
<213> Homo sapiens

<400> 1941
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
    210                 215                 220
Gln Asp Leu Gly Pro Val Pro Met
225                 230

<210> 1942
<211> 232
<212> PRT
<213> Homo sapiens

<400> 1942
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
    210                 215                 220
Gln Asp Leu Gly Pro Val Pro Met
225                 230

<210> 1943
<211> 296
<212> PRT
<213> Homo sapiens

<400> 1943
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160
Ser Phe Pro Glu Asn Leu Thr His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His
    210                 215                 220
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro
225                 230                 235                 240
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn
                245                 250                 255
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser
            260                 265                 270
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
        275                 280                 285
Gln Asp Leu Gly Pro Val Pro Met
    290                 295

<210> 1944
<211> 232
<212> PRT
<213> Homo sapiens

<400> 1944
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
    210                 215                 220
Gln Asp Leu Gly Pro Val Pro Met
225                 230

<210> 1945
<211> 166
<212> PRT
<213> Homo sapiens

<400> 1945
Met Asn Pro Pro Ser Gln Asp Trp Asp Thr Thr Gln Ser Leu Lys Gln
 1               5                  10                  15
Leu Glu Glu Arg Ala Ala Arg Asn Val Ser Gln Val Ser Lys Asn Leu
            20                  25                  30
Glu Ser His His Gly Asp Gln Met Ala Gln Lys Ser Gln Ser Thr Gln
        35                  40                  45
Ile Ser Gln Glu Leu Glu Glu Leu Arg Ala Glu Gln Gln Arg Leu Lys
    50                  55                  60
Ser Gln Asp Leu Glu Leu Ser Trp Asn Leu Asn Gly Leu Gln Ala Asp
65                  70                  75                  80
Leu Ser Ser Phe Lys Ser Gln Glu Leu Asn Glu Arg Asn Glu Ala Ser
                85                  90                  95
Asp Leu Leu Glu Arg Leu Arg Glu Glu Val Thr Lys Leu Arg Met Glu
            100                 105                 110
Leu Gln Val Ser Ser Gly Phe Val Cys Asn Thr Cys Pro Glu Lys Trp
        115                 120                 125
Ile Asn Phe Gln Arg Lys Cys Tyr Tyr Phe Gly Lys Gly Thr Lys Gln
    130                 135                 140
Trp Val His Ala Arg Tyr Ala Cys Asp Asp Met Glu Gly Gln Leu Val
145                 150                 155                 160
Ser Ile His Ser Pro Glu
                165

<210> 1946
<211> 167
<212> PRT
<213> Homo sapiens

<400> 1946
Met Glu Glu Gly Gln Tyr Ser Asp Trp Asp Thr Thr Gln Ser Leu Lys
 1               5                  10                  15
Gln Leu Glu Glu Arg Ala Ala Arg Asn Val Ser Gln Val Ser Lys Asn
            20                  25                  30
Leu Glu Ser His His Gly Asp Gln Met Ala Gln Lys Ser Gln Ser Thr
        35                  40                  45
Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg Ala Glu Gln Gln Arg Leu
    50                  55                  60
Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn Leu Asn Gly Leu Gln Ala
65                  70                  75                  80
Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu Asn Glu Arg Asn Glu Ala
                85                  90                  95
Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu Val Thr Lys Leu Arg Met
            100                 105                 110
Glu Leu Gln Val Ser Ser Gly Phe Val Cys Asn Thr Cys Pro Glu Lys
        115                 120                 125
Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr Phe Gly Lys Gly Thr Lys
    130                 135                 140
Gln Trp Val His Ala Arg Tyr Ala Cys Asp Asp Met Glu Gly Gln Leu
145                 150                 155                 160
Val Ser Ile His Ser Pro Glu
                165

<210> 1947
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1947
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1948
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1948
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1949
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1949
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1950
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1950
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1951
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1951
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1952
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1952
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1953
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1953
Lys Ala Asp Phe Pro Thr Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr
 1               5                  10                  15
Ser Asn Ile Arg Arg Ile Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu
            20                  25                  30
Pro


<210> 1954
<211> 488
<212> PRT
<213> Homo sapiens

<400> 1954
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Asp
                245                 250                 255
Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly
            260                 265                 270
Tyr Ser Phe Thr Gly Tyr Tyr Met His Trp Val Lys Gln Ser His Gly
        275                 280                 285
Lys Ser Leu Glu Trp Ile Gly Arg Ile Asn Pro Asn Asn Gly Val Thr
    290                 295                 300
Leu Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys
305                 310                 315                 320
Ser Ser Thr Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp
                325                 330                 335
Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Met Ile Thr Asn Tyr Val
            340                 345                 350
Met Asp Tyr Trp Gly Gln Val Thr Ser Val Thr Val Ser Ser Gly Gly
        355                 360                 365
Gly Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser Ser Ile Val
    370                 375                 380
Met Thr Gln Thr Pro Thr Phe Leu Leu Val Ser Ala Gly Asp Arg Val
385                 390                 395                 400
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp
                405                 410                 415
Tyr Gln Gln Lys Pro Gly Gln Ser Pro Thr Leu Leu Ile Ser Tyr Thr
            420                 425                 430
Ser Ser Arg Tyr Ala Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Tyr
        435                 440                 445
Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Leu Gln Ala Glu Asp Leu
    450                 455                 460
Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asn Ser Pro Pro Thr Phe Gly
465                 470                 475                 480
Gly Gly Thr Lys Leu Glu Ile Lys
                485

<210> 1955
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1955
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1956
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1956
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1957
<211> 208
<212> PRT
<213> Homo sapiens

<400> 1957
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
 1               5                  10                  15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
            20                  25                  30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
        35                  40                  45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
    50                  55                  60
Lys Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65                  70                  75                  80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
                85                  90                  95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
            100                 105                 110
Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
        115                 120                 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Lys Arg
    130                 135                 140
Glu His Leu Ala Glu Val Ile Asn Thr Thr Val Ser Glu Asp Pro Glu
145                 150                 155                 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
                165                 170                 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
            180                 185                 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
        195                 200                 205

<210> 1958
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1958
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1959
<211> 475
<212> PRT
<213> Homo sapiens

<400> 1959
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp His Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro
                245                 250                 255
Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
            260                 265                 270
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
        275                 280                 285
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
    290                 295                 300
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
305                 310                 315                 320
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                325                 330                 335
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
            340                 345                 350
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
        355                 360                 365
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
    370                 375                 380
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
385                 390                 395                 400
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                405                 410                 415
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
            420                 425                 430
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
        435                 440                 445
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
    450                 455                 460
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
465                 470                 475

<210> 1960
<211> 492
<212> PRT
<213> Homo sapiens

<400> 1960
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Gln Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys
                245                 250                 255
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
            260                 265                 270
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        275                 280                 285
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    290                 295                 300
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
305                 310                 315                 320
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
                325                 330                 335
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
            340                 345                 350
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
        355                 360                 365
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    370                 375                 380
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
385                 390                 395                 400
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                405                 410                 415
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            420                 425                 430
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        435                 440                 445
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    450                 455                 460
Gln Lys Ser Leu Ser Leu Ser Ala Gly Lys Pro Thr His Val Asn Val
465                 470                 475                 480
Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr
                485                 490

<210> 1961
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1961
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1962
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1962
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1963
<211> 488
<212> PRT
<213> Homo sapiens

<400> 1963
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Asp
                245                 250                 255
Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly
            260                 265                 270
Tyr Ser Phe Thr Gly Tyr Tyr Met His Trp Val Lys Gln Ser His Gly
        275                 280                 285
Lys Ser Leu Glu Trp Ile Gly Arg Ile Asn Pro Asn Asn Gly Val Thr
    290                 295                 300
Leu Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys
305                 310                 315                 320
Ser Ser Thr Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp
                325                 330                 335
Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Met Ile Thr Asn Tyr Val
            340                 345                 350
Met Asp Tyr Trp Gly Gln Val Thr Ser Val Thr Val Ser Ser Gly Gly
        355                 360                 365
Gly Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser Ser Ile Val
    370                 375                 380
Met Thr Gln Thr Pro Thr Phe Leu Leu Val Ser Ala Gly Asp Arg Val
385                 390                 395                 400
Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp
                405                 410                 415
Tyr Gln Gln Lys Pro Gly Gln Ser Pro Thr Leu Leu Ile Ser Tyr Thr
            420                 425                 430
Ser Ser Arg Tyr Ala Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Tyr
        435                 440                 445
Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Leu Gln Ala Glu Asp Leu
    450                 455                 460
Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asn Ser Pro Pro Thr Phe Gly
465                 470                 475                 480
Gly Gly Thr Lys Leu Glu Ile Lys
                485

<210> 1964
<211> 480
<212> PRT
<213> Homo sapiens

<400> 1964
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Ala Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Lys Arg Ser Pro Gly Leu Gln Glu Pro Lys Ser Cys Asp Lys Thr
                245                 250                 255
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
            260                 265                 270
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
        275                 280                 285
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
    290                 295                 300
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
305                 310                 315                 320
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
                325                 330                 335
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
            340                 345                 350
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
        355                 360                 365
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
    370                 375                 380
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
385                 390                 395                 400
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                405                 410                 415
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
            420                 425                 430
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
        435                 440                 445
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
    450                 455                 460
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
465                 470                 475                 480

<210> 1965
<211> 251
<212> PRT
<213> Homo sapiens

<400> 1965
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Gln His Phe Pro
225                 230                 235                 240
Asp Asn Glu Glu Glu Glu Tyr Met Pro Met Glu
                245                 250

<210> 1966
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1966
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1967
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1967
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1968
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1968
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1969
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1969
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1970
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1970
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 1971
<211> 276
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(276)
<223> Xaa = Any Amino Acid

<400> 1971
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
 1               5                  10                  15
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
            20                  25                  30
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
        35                  40                  45
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
    50                  55                  60
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
65                  70                  75                  80
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
                85                  90                  95
Xaa Xaa Gln Leu Leu Leu Lys Ala Thr Pro Glu Xaa Asn Gly Xaa Ser
            100                 105                 110
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
        115                 120                 125
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
    130                 135                 140
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
145                 150                 155                 160
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
                165                 170                 175
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
            180                 185                 190
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
        195                 200                 205
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
    210                 215                 220
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
225                 230                 235                 240
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
                245                 250                 255
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
            260                 265                 270
Ala Thr Pro Pro
        275

<210> 1972
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1972
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val
    450                 455                 460
Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg
465                 470                 475                 480
Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met
                485                 490                 495
Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1973
<211> 453
<212> PRT
<213> Homo sapiens

<400> 1973
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu
    450

<210> 1974
<211> 680
<212> PRT
<213> Homo sapiens

<400> 1974
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Lys Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
    450                 455                 460
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
465                 470                 475                 480
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                485                 490                 495
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
            500                 505                 510
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        515                 520                 525
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    530                 535                 540
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
545                 550                 555                 560
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                565                 570                 575
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
            580                 585                 590
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        595                 600                 605
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    610                 615                 620
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
625                 630                 635                 640
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
                645                 650                 655
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            660                 665                 670
Ser Leu Ser Leu Ser Pro Gly Lys
        675                 680

<210> 1975
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1975
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1976
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1976
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Cys
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1977
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1977
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Cys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1978
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1978
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1979
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1979
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Cys His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1980
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1980
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Cys Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1981
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1981
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Cys Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1982
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1982
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1983
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1983
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Cys Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1984
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1984
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Cys Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1985
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1985
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Cys Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1986
<211> 453
<212> PRT
<213> Homo sapiens

<400> 1986
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Cys Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg
    450

<210> 1987
<211> 453
<212> PRT
<213> Homo sapiens

<400> 1987
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Cys Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg
    450

<210> 1988
<211> 453
<212> PRT
<213> Homo sapiens

<400> 1988
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg
    450

<210> 1989
<211> 453
<212> PRT
<213> Homo sapiens

<400> 1989
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg
    450

<210> 1990
<211> 454
<212> PRT
<213> Homo sapiens

<400> 1990
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Lys
    450

<210> 1991
<211> 509
<212> PRT
<213> Homo sapiens

<400> 1991
Gln Glu Phe Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala
 1               5                  10                  15
Gly Gly Ser Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu
            20                  25                  30
Lys Ile Ala Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly
        35                  40                  45
Met Gly Trp Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg
    50                  55                  60
Ile Leu Cys Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser
65                  70                  75                  80
Asn Ile Thr Val Tyr Gly Leu Pro Glu Arg Val Glu Leu Glu Leu Ala
                85                  90                  95
Pro Leu Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys
            100                 105                 110
Gln Val Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu
        115                 120                 125
Arg Gly Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala
    130                 135                 140
Glu Val Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn
145                 150                 155                 160
Phe Ser Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu
                165                 170                 175
Phe Glu Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro
            180                 185                 190
Ala Thr Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr
        195                 200                 205
Gln Gly Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu
    210                 215                 220
Ala Gln Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val
225                 230                 235                 240
Thr Tyr Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr
                245                 250                 255
Ala Glu Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly
            260                 265                 270
Asn Gln Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro
        275                 280                 285
Ala Pro Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu
    290                 295                 300
Val Thr Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn
305                 310                 315                 320
Gly Val Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys
                325                 330                 335
Ala Thr Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu
            340                 345                 350
Glu Val Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg
        355                 360                 365
Val Leu Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp
    370                 375                 380
Thr Trp Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly
385                 390                 395                 400
Asn Pro Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu
                405                 410                 415
Pro Ile Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr
            420                 425                 430
Leu Cys Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr
        435                 440                 445
Val Asn Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val
    450                 455                 460
Ala Ala Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr
465                 470                 475                 480
Asn Arg Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys
                485                 490                 495
Gly Thr Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1992
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1992
Gln Glu Phe Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala
 1               5                  10                  15
Gly Gly Ser Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu
            20                  25                  30
Lys Ile Ala Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly
        35                  40                  45
Met Gly Trp Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg
    50                  55                  60
Ile Leu Cys Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser
65                  70                  75                  80
Asn Ile Thr Val Tyr Gly Leu Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Pro Trp Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp
        115                 120                 125
Glu Glu Glu Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val
    130                 135                 140
Thr Ala Thr Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val
                165                 170                 175
Asn Thr Ser Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1993
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1993
Gln Glu Phe Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala
 1               5                  10                  15
Gly Gly Ser Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu
            20                  25                  30
Lys Ile Ala Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly
        35                  40                  45
Met Gly Trp Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg
    50                  55                  60
Ile Leu Cys Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser
65                  70                  75                  80
Asn Ile Thr Val Tyr Gly Leu Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Pro Trp Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp
        115                 120                 125
Glu Glu Glu Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val
    130                 135                 140
Thr Ala Thr Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val
                165                 170                 175
Asn Thr Ser Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Val Thr
            180                 185                 190
Pro Pro Arg Leu Val Ala Pro Arg Phe Leu Glu Val Glu Thr Ser Trp
        195                 200                 205
Pro Val Asp Cys Thr Leu Asp Gly Leu Phe Pro Ala Ser Glu Ala Gln
    210                 215                 220
Val Tyr Leu Ala Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn
225                 230                 235                 240
His Gly Asp Thr Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala Asp
                245                 250                 255
Gln Glu Gly Ala Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu
            260                 265                 270
Arg Arg Glu Ala Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro
        275                 280                 285
Ile Val Asn Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1994
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1994
Asn Ala Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly
 1               5                  10                  15
Gly Ser Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu
            20                  25                  30
Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly
        35                  40                  45
Asn Asn Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln
    50                  55                  60
Pro Met Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr
65                  70                  75                  80
Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu
                85                  90                  95
Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val
            100                 105                 110
Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
        115                 120                 125
Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val
    130                 135                 140
Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser
145                 150                 155                 160
Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu
                165                 170                 175
Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr
            180                 185                 190
Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly
        195                 200                 205
Thr Val Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln
    210                 215                 220
Val His Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr
225                 230                 235                 240
Gly Asn Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu
                245                 250                 255
Asp Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln
            260                 265                 270
Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro
        275                 280                 285
Asn Val Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr
    290                 295                 300
Val Lys Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val
305                 310                 315                 320
Pro Ala Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr
                325                 330                 335
Pro Glu Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val
            340                 345                 350
Ala Gly Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu
        355                 360                 365
Tyr Gly Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp
    370                 375                 380
Pro Glu Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro
385                 390                 395                 400
Leu Pro Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile
                405                 410                 415
Gly Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys
            420                 425                 430
Arg Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn
        435                 440                 445
Val Leu Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala
    450                 455                 460
Ala Val Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg
465                 470                 475                 480
Gln Arg Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr
                485                 490                 495
Pro Met Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1995
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1995
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val
    450                 455                 460
Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg
465                 470                 475                 480
Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met
                485                 490                 495
Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1996
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1996
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val
    450                 455                 460
Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg
465                 470                 475                 480
Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met
                485                 490                 495
Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1997
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1997
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val
    450                 455                 460
Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg
465                 470                 475                 480
Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met
                485                 490                 495
Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1998
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1998
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val
    450                 455                 460
Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg
465                 470                 475                 480
Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met
                485                 490                 495
Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 1999
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1999
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val
    450                 455                 460
Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg
465                 470                 475                 480
Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met
                485                 490                 495
Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 2000
<211> 505
<212> PRT
<213> Homo sapiens

<400> 2000
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val
    450                 455                 460
Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg
465                 470                 475                 480
Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met
                485                 490                 495
Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 2001
<211> 505
<212> PRT
<213> Homo sapiens

<400> 2001
Gln Thr Ser Val Ser Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser
 1               5                  10                  15
Val Leu Val Thr Cys Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly
            20                  25                  30
Ile Glu Thr Pro Leu Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn
        35                  40                  45
Arg Lys Val Tyr Glu Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met
    50                  55                  60
Cys Tyr Ser Asn Cys Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu
65                  70                  75                  80
Thr Val Tyr Trp Thr Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser
                85                  90                  95
Trp Gln Pro Val Gly Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly
            100                 105                 110
Gly Ala Pro Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys
        115                 120                 125
Glu Leu Lys Arg Glu Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr
    130                 135                 140
Thr Val Leu Val Arg Arg Asp His His Gly Ala Asn Phe Ser Cys Arg
145                 150                 155                 160
Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr
                165                 170                 175
Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro
            180                 185                 190
Gln Leu Val Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val
        195                 200                 205
Val Cys Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Ala Gln Val His
    210                 215                 220
Leu Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn
225                 230                 235                 240
Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu
                245                 250                 255
Gly Thr Gln Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln
            260                 265                 270
Glu Thr Leu Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val
        275                 280                 285
Ile Leu Thr Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys
    290                 295                 300
Cys Glu Ala His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala
305                 310                 315                 320
Gln Pro Leu Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu
                325                 330                 335
Asp Asn Gly Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly
            340                 345                 350
Gln Leu Ile His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly
        355                 360                 365
Pro Arg Leu Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu
    370                 375                 380
Asn Ser Gln Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro
385                 390                 395                 400
Glu Leu Lys Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu
                405                 410                 415
Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala
            420                 425                 430
Arg Ser Thr Gln Gly Glu Val Thr Arg Lys Val Thr Val Asn Val Leu
        435                 440                 445
Ser Pro Arg Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val
    450                 455                 460
Ile Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg
465                 470                 475                 480
Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met
                485                 490                 495
Lys Pro Asn Thr Gln Ala Thr Pro Pro
            500                 505

<210> 2002
<211> 276
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(276)
<223> Xaa = Any Amino Acid

<400> 2002
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
 1               5                  10                  15
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
            20                  25                  30
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
        35                  40                  45
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
    50                  55                  60
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
65                  70                  75                  80
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
                85                  90                  95
Xaa Xaa Gln Leu Leu Leu Lys Ala Thr Pro Glu Xaa Asn Gly Xaa Ser
            100                 105                 110
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
        115                 120                 125
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
    130                 135                 140
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
145                 150                 155                 160
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
                165                 170                 175
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
            180                 185                 190
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
        195                 200                 205
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
    210                 215                 220
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
225                 230                 235                 240
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
                245                 250                 255
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
            260                 265                 270
Ala Thr Pro Pro
        275

<210> 2003
<211> 236
<212> PRT
<213> Homo sapiens

<400> 2003
Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val
 1               5                  10                  15
Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala
            20                  25                  30
Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu
        35                  40                  45
Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile
    50                  55                  60
Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys
65                  70                  75                  80
Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr
                85                  90                  95
Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly
            100                 105                 110
Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp
        115                 120                 125
Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys
    130                 135                 140
Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser
145                 150                 155                 160
Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro
                165                 170                 175
Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln
            180                 185                 190
Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala
        195                 200                 205
Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met
    210                 215                 220
Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr
225                 230                 235

<210> 2004
<211> 236
<212> PRT
<213> Homo sapiens

<400> 2004
Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val
 1               5                  10                  15
Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala
            20                  25                  30
Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu
        35                  40                  45
Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile
    50                  55                  60
Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys
65                  70                  75                  80
Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr
                85                  90                  95
Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly
            100                 105                 110
Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp
        115                 120                 125
Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys
    130                 135                 140
Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser
145                 150                 155                 160
Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro
                165                 170                 175
Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln
            180                 185                 190
Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala
        195                 200                 205
Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met
    210                 215                 220
Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr
225                 230                 235

<210> 2005
<211> 262
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(262)
<223> Xaa = Any Amino Acid

<400> 2005
Ser Ser Val Pro Gly Gly Tyr Pro Gly Thr Glu His Ser His Arg Cys
 1               5                  10                  15
Arg Arg Phe Tyr Gln Leu Ala Leu Gly Trp Thr Thr Leu Ala Lys Thr
            20                  25                  30
Ser Trp Leu Glu Asp Xaa Ser Pro Asp Leu Val Pro Arg Gly Ser Gln
        35                  40                  45
Leu Ala Gly Gly Val Ile Leu Gly Val Ala Leu Trp Leu Arg His Asp
    50                  55                  60
Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro Ala
65                  70                  75                  80
Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile Leu Ile Ala Val Gly Ala
                85                  90                  95
Val Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu
            100                 105                 110
Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr Cys Leu Val Ile Leu Phe
        115                 120                 125
Ala Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln
    130                 135                 140
Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala
145                 150                 155                 160
Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val Lys Thr Phe
                165                 170                 175
His Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu Thr Ala Leu Thr
            180                 185                 190
Thr Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile
        195                 200                 205
Ser Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe
    210                 215                 220
Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val
225                 230                 235                 240
Ile Met Ile Phe Glu Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile
                245                 250                 255
Arg Asn Ser Ser Val Tyr
            260

<210> 2006
<211> 236
<212> PRT
<213> Homo sapiens

<400> 2006
Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val
 1               5                  10                  15
Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala
            20                  25                  30
Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu
        35                  40                  45
Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile
    50                  55                  60
Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys
65                  70                  75                  80
Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr
                85                  90                  95
Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly
            100                 105                 110
Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp
        115                 120                 125
Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys
    130                 135                 140
Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser
145                 150                 155                 160
Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro
                165                 170                 175
Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln
            180                 185                 190
Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala
        195                 200                 205
Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met
    210                 215                 220
Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr
225                 230                 235

<210> 2007
<211> 279
<212> PRT
<213> Homo sapiens

<400> 2007
Met Pro Val Cys Ala Pro Val Leu Trp Arg Ala Arg Arg Leu Cys Gly
 1               5                  10                  15
Met Pro Val Cys Ala Pro Val Pro Trp Arg Ala Arg Arg Leu Cys Thr
            20                  25                  30
Arg Ala Val Val Cys Pro Ser Ser Val Pro Phe Ile Ala Gly Gln Gly
        35                  40                  45
Cys Thr His Met Cys Lys Pro Ala Thr Asp Pro Arg Phe Thr Arg Ser
    50                  55                  60
Pro Leu Ala Gly Gly Val Ile Leu Gly Val Ala Leu Trp Leu Arg His
65                  70                  75                  80
Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu Leu Gly Asp Lys Pro
                85                  90                  95
Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile Leu Ile Ala Val Gly
            100                 105                 110
Ala Val Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln
        115                 120                 125
Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr Cys Leu Val Ile Leu
    130                 135                 140
Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp
145                 150                 155                 160
Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln
                165                 170                 175
Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val Lys Thr
            180                 185                 190
Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu Thr Ala Leu
        195                 200                 205
Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile
    210                 215                 220
Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp Asp Leu
225                 230                 235                 240
Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala
                245                 250                 255
Val Ile Met Ile Phe Glu Met Ile Leu Ser Met Val Leu Cys Cys Gly
            260                 265                 270
Ile Arg Asn Ser Ser Val Tyr
        275

<210> 2008
<211> 236
<212> PRT
<213> Homo sapiens

<400> 2008
Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val
 1               5                  10                  15
Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala
            20                  25                  30
Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu
        35                  40                  45
Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile
    50                  55                  60
Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys
65                  70                  75                  80
Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr
                85                  90                  95
Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly
            100                 105                 110
Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp
        115                 120                 125
Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys
    130                 135                 140
Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser
145                 150                 155                 160
Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro
                165                 170                 175
Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln
            180                 185                 190
Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala
        195                 200                 205
Ala Ile Val Val Ala Val Ile His Ile Phe Glu His Ile Leu Ser Met
    210                 215                 220
Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Ile
225                 230                 235

<210> 2009
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2009
Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly Ser Gly Asp Asp Asp
 1               5                  10                  15
Asp Lys Val Pro Gly Met Leu Ser Ser Ser Phe Val Asn Lys Asp Gln
            20                  25                  30
Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala
        35                  40                  45
Val Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val Lys Thr Phe
    50                  55                  60
His Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu Thr Ala Leu Thr
65                  70                  75                  80
Thr Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile
                85                  90                  95
Ser Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe
            100                 105                 110
Ser Gly Lys Leu
        115

<210> 2010
<211> 113
<212> PRT
<213> Homo sapiens

<400> 2010
Leu Val Pro Arg Gly Ser Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile
 1               5                  10                  15
Leu Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr
            20                  25                  30
Asp Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala
        35                  40                  45
Lys Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser
    50                  55                  60
Ser Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys
65                  70                  75                  80
Pro Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His
                85                  90                  95
Gln Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu His His His His His
            100                 105                 110
His


<210> 2011
<211> 236
<212> PRT
<213> Homo sapiens

<400> 2011
Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val
 1               5                  10                  15
Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala
            20                  25                  30
Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu
        35                  40                  45
Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile
    50                  55                  60
Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys
65                  70                  75                  80
Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr
                85                  90                  95
Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly
            100                 105                 110
Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp
        115                 120                 125
Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys
    130                 135                 140
Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser
145                 150                 155                 160
Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro
                165                 170                 175
Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln
            180                 185                 190
Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala
        195                 200                 205
Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met
    210                 215                 220
Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr
225                 230                 235

<210> 2012
<211> 847
<212> PRT
<213> Homo sapiens

<400> 2012
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg
                245                 250                 255
Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro
            260                 265                 270
Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys
        275                 280                 285
Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser
    290                 295                 300
Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser
305                 310                 315                 320
Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val
                325                 330                 335
Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu
            340                 345                 350
Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His
        355                 360                 365
Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro
    370                 375                 380
Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn
385                 390                 395                 400
Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln
                405                 410                 415
Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile
            420                 425                 430
Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn
        435                 440                 445
Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu
    450                 455                 460
Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr
465                 470                 475                 480
Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro
                485                 490                 495
Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys
            500                 505                 510
Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln
        515                 520                 525
Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu
    530                 535                 540
Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser
545                 550                 555                 560
Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser
                565                 570                 575
Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala
            580                 585                 590
Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu
        595                 600                 605
Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val
    610                 615                 620
Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His
625                 630                 635                 640
Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala
                645                 650                 655
Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu
            660                 665                 670
Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val
        675                 680                 685
Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys
    690                 695                 700
Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly
705                 710                 715                 720
Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys
                725                 730                 735
Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr
            740                 745                 750
Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro
        755                 760                 765
Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln
    770                 775                 780
Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His
785                 790                 795                 800
Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu
                805                 810                 815
Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu
            820                 825                 830
Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His
        835                 840                 845

<210> 2013
<211> 670
<212> PRT
<213> Homo sapiens

<400> 2013
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg
                245                 250                 255
Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro
            260                 265                 270
Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro
        275                 280                 285
Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr
    290                 295                 300
Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val
305                 310                 315                 320
Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile
                325                 330                 335
Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys
            340                 345                 350
Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys
        355                 360                 365
Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile
    370                 375                 380
Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile
385                 390                 395                 400
Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro
                405                 410                 415
Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly
            420                 425                 430
Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser
        435                 440                 445
His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser
    450                 455                 460
Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr
465                 470                 475                 480
Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser
                485                 490                 495
Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala
            500                 505                 510
Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly
        515                 520                 525
Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu
    530                 535                 540
Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val
545                 550                 555                 560
Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn
                565                 570                 575
Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu
            580                 585                 590
Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg
        595                 600                 605
Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys
    610                 615                 620
Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp
625                 630                 635                 640
Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg
                645                 650                 655
Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His
            660                 665                 670

<210> 2014
<211> 647
<212> PRT
<213> Homo sapiens

<400> 2014
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg
                245                 250                 255
Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro
            260                 265                 270
Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro
        275                 280                 285
Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr
    290                 295                 300
Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val
305                 310                 315                 320
Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile
                325                 330                 335
Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys
            340                 345                 350
Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys
        355                 360                 365
Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile
    370                 375                 380
Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile
385                 390                 395                 400
Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro
                405                 410                 415
Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly
            420                 425                 430
Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser
        435                 440                 445
His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser
    450                 455                 460
Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr
465                 470                 475                 480
Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser
                485                 490                 495
Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala
            500                 505                 510
Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly
        515                 520                 525
Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu
    530                 535                 540
Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val
545                 550                 555                 560
Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn
                565                 570                 575
Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu
            580                 585                 590
Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg
        595                 600                 605
Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys
    610                 615                 620
Arg Gln Val Gly Thr Met Arg Thr Ser Phe Gln Ile Phe Gln Lys Met
625                 630                 635                 640
Arg Gly Phe Ile Thr Gln Ser
                645

<210> 2015
<211> 662
<212> PRT
<213> Homo sapiens

<400> 2015
Met Glu Ser Lys Thr Glu Lys Trp Met Glu Arg Ile His Leu Asn Val
 1               5                  10                  15
Ser Glu Arg Pro Phe Pro Pro His Ile Gln Leu Pro Pro Glu Ile Gln
            20                  25                  30
Glu Ser Gln Glu Val Thr Leu Thr Cys Leu Leu Asn Phe Ser Cys Tyr
        35                  40                  45
Gly Tyr Pro Ile Gln Leu Gln Trp Leu Leu Glu Gly Val Pro Met Arg
    50                  55                  60
Gln Ala Ala Val Thr Ser Thr Ser Leu Thr Ile Lys Ser Val Phe Thr
65                  70                  75                  80
Arg Ser Glu Leu Lys Phe Ser Pro Gln Trp Ser His His Gly Lys Ile
                85                  90                  95
Val Thr Cys Gln Leu Gln Asp Ala Asp Gly Lys Phe Leu Ser Asn Asp
            100                 105                 110
Thr Val Gln Leu Asn Val Lys His Thr Pro Lys Leu Glu Ile Lys Val
        115                 120                 125
Thr Pro Ser Asp Ala Ile Val Arg Glu Gly Asp Ser Val Thr Met Thr
    130                 135                 140
Cys Glu Val Ser Ser Thr Asn Pro Glu Tyr Thr Thr Val Ser Trp Leu
145                 150                 155                 160
Lys Asp Gly Thr Ser Leu Lys Lys Gln Asn Thr Phe Thr Leu Asn Leu
                165                 170                 175
Arg Glu Val Thr Lys Asp Gln Ser Gly Lys Tyr Cys Cys Gln Val Ser
            180                 185                 190
Asn Asp Val Gly Pro Gly Arg Ser Glu Glu Val Phe Leu Gln Val Gln
        195                 200                 205
Tyr Ala Pro Glu Pro Ser Thr Val Gln Ile Leu His Ser Pro Ala Val
    210                 215                 220
Glu Gly Ser Gln Val Glu Phe Leu Cys Met Ser Leu Ala Asn Pro Leu
225                 230                 235                 240
Pro Thr Asn Tyr Thr Trp Tyr His Asn Gly Lys Glu Met Gln Gly Arg
                245                 250                 255
Thr Glu Glu Lys Val His Ile Pro Lys Ile Leu Pro Trp His Ala Gly
            260                 265                 270
Thr Tyr Ser Cys Val Ala Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly
        275                 280                 285
Pro Gly Ala Glu Leu Asp Val Gln Tyr Pro Pro Lys Lys Val Thr Thr
    290                 295                 300
Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu
305                 310                 315                 320
Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp
                325                 330                 335
Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile
            340                 345                 350
Gln Lys Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Arg Cys Asn
        355                 360                 365
Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala
    370                 375                 380
Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His
385                 390                 395                 400
Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro
                405                 410                 415
Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys
            420                 425                 430
Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser
        435                 440                 445
Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala
    450                 455                 460
Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met
465                 470                 475                 480
Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Arg Cys
                485                 490                 495
Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp
            500                 505                 510
Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro
        515                 520                 525
Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser
    530                 535                 540
Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser
545                 550                 555                 560
Pro Glu Thr Ile Gly Arg Arg Val Ala Val Gly Leu Gly Ser Cys Leu
                565                 570                 575
Ala Ile Leu Ile Leu Ala Ile Cys Gly Leu Lys Leu Gln Arg Arg Asp
            580                 585                 590
Ala Glu Ser Ser Glu Met Gln Arg Pro Pro Arg Thr Cys Asp Asp Thr
        595                 600                 605
Val Thr Tyr Ser Ala Leu His Lys Arg Gln Val Gly Asp Tyr Glu Asn
    610                 615                 620
Val Ile Pro Asp Phe Pro Glu Asp Glu Gly Ile His Tyr Ser Glu Leu
625                 630                 635                 640
Ile Gln Phe Gly Val Gly Glu Arg Pro Gln Ala Gln Glu Asn Val Asp
                645                 650                 655
Tyr Val Ile Leu Lys His
            660

<210> 2016
<211> 847
<212> PRT
<213> Homo sapiens

<400> 2016
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg
                245                 250                 255
Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro
            260                 265                 270
Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys
        275                 280                 285
Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser
    290                 295                 300
Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser
305                 310                 315                 320
Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val
                325                 330                 335
Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu
            340                 345                 350
Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His
        355                 360                 365
Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro
    370                 375                 380
Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn
385                 390                 395                 400
Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln
                405                 410                 415
Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile
            420                 425                 430
Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn
        435                 440                 445
Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu
    450                 455                 460
Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr
465                 470                 475                 480
Thr Ile Ala Cys Ala Arg Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro
                485                 490                 495
Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys
            500                 505                 510
Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln
        515                 520                 525
Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu
    530                 535                 540
Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser
545                 550                 555                 560
Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser
                565                 570                 575
Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala
            580                 585                 590
Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu
        595                 600                 605
Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val
    610                 615                 620
Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro His His
625                 630                 635                 640
Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala
                645                 650                 655
Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu
            660                 665                 670
Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val
        675                 680                 685
Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys
    690                 695                 700
Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly
705                 710                 715                 720
Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys
                725                 730                 735
Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr
            740                 745                 750
Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro
        755                 760                 765
Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln
    770                 775                 780
Arg Pro Pro Arg Thr Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His
785                 790                 795                 800
Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu
                805                 810                 815
Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu
            820                 825                 830
Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His
        835                 840                 845

<210> 2017
<211> 101
<212> PRT
<213> Homo sapiens

<400> 2017
Arg Pro Phe Pro Pro His Ile Gln Leu Pro Pro Glu Ile Glu Glu Ser
 1               5                  10                  15
Gln Glu Val Thr Leu Thr Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr
            20                  25                  30
Pro Ile Gln Leu Gln Trp Leu Leu Glu Gly Val Pro Met Arg Gln Ala
        35                  40                  45
Ala Val Thr Ser Thr Ser Leu Thr Ile Lys Ser Val Phe Thr Arg Ser
    50                  55                  60
Glu Leu Lys Phe Ser Pro Gln Trp Ser His His Gly Lys Ile Val Thr
65                  70                  75                  80
Cys Gln Leu Gln Asp Ala Asp Gly Lys Phe Leu Ser Asn Asp Thr Val
                85                  90                  95
Gln Leu Asn Val Lys
            100

<210> 2018
<211> 101
<212> PRT
<213> Homo sapiens

<400> 2018
Arg Pro Phe Pro Pro His Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser
 1               5                  10                  15
Gln Glu Val Thr Leu Thr Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr
            20                  25                  30
Pro Ile Gln Leu Gln Trp Leu Leu Glu Gly Val Pro Met Arg Gln Ala
        35                  40                  45
Ala Val Thr Ser Thr Ser Leu Thr Ile Lys Ser Val Phe Thr Arg Ser
    50                  55                  60
Lys Leu Lys Phe Ser Pro Gln Trp Ser His His Gly Lys Ile Val Thr
65                  70                  75                  80
Cys Gln Leu Gln Asp Ala Asp Gly Lys Phe Leu Ser Asn Asp Thr Val
                85                  90                  95
Gln Leu Asn Val Lys
            100

<210> 2019
<211> 101
<212> PRT
<213> Homo sapiens

<400> 2019
Arg Pro Phe Pro Pro His Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser
 1               5                  10                  15
Gln Glu Val Thr Leu Thr Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr
            20                  25                  30
Pro Ile Gln Leu Gln Trp Leu Leu Glu Gly Val Pro Met Arg Gln Ala
        35                  40                  45
Ala Val Thr Ser Thr Ser Leu Thr Ile Lys Ser Val Phe Thr Arg Ser
    50                  55                  60
Glu Leu Lys Phe Ser Pro Gln Trp Ser His His Gly Lys Ile Val Thr
65                  70                  75                  80
Cys Gln Leu Gln Asp Ala Asp Gly Lys Phe Leu Ser Asn Asp Thr Val
                85                  90                  95
Gln Leu Asn Val Lys
            100

<210> 2020
<211> 647
<212> PRT
<213> Homo sapiens

<400> 2020
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg
                245                 250                 255
Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro
            260                 265                 270
Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro
        275                 280                 285
Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr
    290                 295                 300
Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val
305                 310                 315                 320
Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile
                325                 330                 335
Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys
            340                 345                 350
Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys
        355                 360                 365
Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile
    370                 375                 380
Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile
385                 390                 395                 400
Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro
                405                 410                 415
Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly
            420                 425                 430
Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser
        435                 440                 445
His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser
    450                 455                 460
Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr
465                 470                 475                 480
Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser
                485                 490                 495
Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala
            500                 505                 510
Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly
        515                 520                 525
Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu
    530                 535                 540
Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val
545                 550                 555                 560
Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn
                565                 570                 575
Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu
            580                 585                 590
Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg
        595                 600                 605
Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys
    610                 615                 620
Arg Gln Val Gly Thr Met Arg Thr Ser Phe Gln Ile Phe Gln Lys Met
625                 630                 635                 640
Arg Gly Phe Ile Thr Gln Ser
                645

<210> 2021
<211> 647
<212> PRT
<213> Homo sapiens

<400> 2021
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg
                245                 250                 255
Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro
            260                 265                 270
Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro
        275                 280                 285
Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr
    290                 295                 300
Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val
305                 310                 315                 320
Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile
                325                 330                 335
Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys
            340                 345                 350
Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys
        355                 360                 365
Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile
    370                 375                 380
Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile
385                 390                 395                 400
Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro
                405                 410                 415
Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly
            420                 425                 430
Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser
        435                 440                 445
His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser
    450                 455                 460
Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr
465                 470                 475                 480
Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser
                485                 490                 495
Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala
            500                 505                 510
Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly
        515                 520                 525
Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu
    530                 535                 540
Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val
545                 550                 555                 560
Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn
                565                 570                 575
Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu
            580                 585                 590
Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg
        595                 600                 605
Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys
    610                 615                 620
Arg Gln Val Gly Thr Met Arg Thr Ser Phe Gln Ile Phe Gln Lys Met
625                 630                 635                 640
Arg Gly Phe Ile Thr Gln Ser
                645

<210> 2022
<211> 647
<212> PRT
<213> Homo sapiens

<400> 2022
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Asn Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Arg Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg
                245                 250                 255
Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro
            260                 265                 270
Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro
        275                 280                 285
Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr
    290                 295                 300
Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val
305                 310                 315                 320
Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile
                325                 330                 335
Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys
            340                 345                 350
Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys
        355                 360                 365
Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile
    370                 375                 380
Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile
385                 390                 395                 400
Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro
                405                 410                 415
Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly
            420                 425                 430
Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser
        435                 440                 445
His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser
    450                 455                 460
Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr
465                 470                 475                 480
Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser
                485                 490                 495
Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala
            500                 505                 510
Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly
        515                 520                 525
Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu
    530                 535                 540
Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val
545                 550                 555                 560
Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn
                565                 570                 575
Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu
            580                 585                 590
Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg
        595                 600                 605
Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys
    610                 615                 620
Arg Gln Val Gly Thr Met Arg Thr Ser Phe Gln Ile Phe Gln Lys Met
625                 630                 635                 640
Arg Gly Phe Ile Thr Gln Ser
                645

<210> 2023
<211> 647
<212> PRT
<213> Homo sapiens

<400> 2023
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg
                245                 250                 255
Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro
            260                 265                 270
Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro
        275                 280                 285
Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr
    290                 295                 300
Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val
305                 310                 315                 320
Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile
                325                 330                 335
Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys
            340                 345                 350
Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys
        355                 360                 365
Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile
    370                 375                 380
Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile
385                 390                 395                 400
Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro
                405                 410                 415
Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly
            420                 425                 430
Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser
        435                 440                 445
His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser
    450                 455                 460
Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr
465                 470                 475                 480
Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser
                485                 490                 495
Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala
            500                 505                 510
Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly
        515                 520                 525
Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu
    530                 535                 540
Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val
545                 550                 555                 560
Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn
                565                 570                 575
Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu
            580                 585                 590
Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg
        595                 600                 605
Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys
    610                 615                 620
Arg Gln Val Gly Thr Met Arg Thr Ser Phe Gln Ile Phe Gln Lys Met
625                 630                 635                 640
Arg Gly Phe Ile Thr Gln Ser
                645

<210> 2024
<211> 647
<212> PRT
<213> Homo sapiens

<400> 2024
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg
                245                 250                 255
Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro
            260                 265                 270
Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro
        275                 280                 285
Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr
    290                 295                 300
Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val
305                 310                 315                 320
Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile
                325                 330                 335
Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys
            340                 345                 350
Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys
        355                 360                 365
Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile
    370                 375                 380
Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile
385                 390                 395                 400
Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro
                405                 410                 415
Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly
            420                 425                 430
Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser
        435                 440                 445
His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser
    450                 455                 460
Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr
465                 470                 475                 480
Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser
                485                 490                 495
Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala
            500                 505                 510
Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly
        515                 520                 525
Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu
    530                 535                 540
Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val
545                 550                 555                 560
Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn
                565                 570                 575
Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu
            580                 585                 590
Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg
        595                 600                 605
Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys
    610                 615                 620
Arg Gln Val Gly Thr Met Arg Thr Ser Phe Gln Ile Phe Gln Lys Met
625                 630                 635                 640
Arg Gly Phe Ile Thr Gln Ser
                645

<210> 2025
<211> 647
<212> PRT
<213> Homo sapiens

<400> 2025
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg
                245                 250                 255
Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro
            260                 265                 270
Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro
        275                 280                 285
Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr
    290                 295                 300
Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val
305                 310                 315                 320
Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile
                325                 330                 335
Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys
            340                 345                 350
Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys
        355                 360                 365
Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile
    370                 375                 380
Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile
385                 390                 395                 400
Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro
                405                 410                 415
Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly
            420                 425                 430
Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser
        435                 440                 445
His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser
    450                 455                 460
Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr
465                 470                 475                 480
Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser
                485                 490                 495
Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala
            500                 505                 510
Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly
        515                 520                 525
Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu
    530                 535                 540
Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val
545                 550                 555                 560
Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn
                565                 570                 575
Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu
            580                 585                 590
Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg
        595                 600                 605
Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys
    610                 615                 620
Arg Gln Val Gly Thr Met Arg Thr Ser Phe Gln Ile Phe Gln Lys Met
625                 630                 635                 640
Arg Gly Phe Ile Thr Gln Ser
                645

<210> 2026
<211> 847
<212> PRT
<213> Homo sapiens

<400> 2026
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg
                245                 250                 255
Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro
            260                 265                 270
Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys
        275                 280                 285
Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser
    290                 295                 300
Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser
305                 310                 315                 320
Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val
                325                 330                 335
Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu
            340                 345                 350
Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His
        355                 360                 365
Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro
    370                 375                 380
Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn
385                 390                 395                 400
Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln
                405                 410                 415
Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile
            420                 425                 430
Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn
        435                 440                 445
Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu
    450                 455                 460
Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr
465                 470                 475                 480
Thr Ile Ala Cys Ala Arg Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro
                485                 490                 495
Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys
            500                 505                 510
Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln
        515                 520                 525
Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu
    530                 535                 540
Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser
545                 550                 555                 560
Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser
                565                 570                 575
Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala
            580                 585                 590
Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu
        595                 600                 605
Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val
    610                 615                 620
Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro His His
625                 630                 635                 640
Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala
                645                 650                 655
Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu
            660                 665                 670
Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val
        675                 680                 685
Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys
    690                 695                 700
Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly
705                 710                 715                 720
Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys
                725                 730                 735
Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr
            740                 745                 750
Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro
        755                 760                 765
Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln
    770                 775                 780
Arg Pro Pro Arg Thr Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His
785                 790                 795                 800
Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu
                805                 810                 815
Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu
            820                 825                 830
Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His
        835                 840                 845

<210> 2027
<211> 847
<212> PRT
<213> Homo sapiens

<400> 2027
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg
                245                 250                 255
Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro
            260                 265                 270
Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys
        275                 280                 285
Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser
    290                 295                 300
Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser
305                 310                 315                 320
Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val
                325                 330                 335
Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu
            340                 345                 350
Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His
        355                 360                 365
Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro
    370                 375                 380
Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn
385                 390                 395                 400
Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln
                405                 410                 415
Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile
            420                 425                 430
Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn
        435                 440                 445
Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu
    450                 455                 460
Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr
465                 470                 475                 480
Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro
                485                 490                 495
Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys
            500                 505                 510
Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln
        515                 520                 525
Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu
    530                 535                 540
Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser
545                 550                 555                 560
Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser
                565                 570                 575
Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala
            580                 585                 590
Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu
        595                 600                 605
Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val
    610                 615                 620
Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His
625                 630                 635                 640
Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala
                645                 650                 655
Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu
            660                 665                 670
Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val
        675                 680                 685
Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys
    690                 695                 700
Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly
705                 710                 715                 720
Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys
                725                 730                 735
Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr
            740                 745                 750
Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro
        755                 760                 765
Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln
    770                 775                 780
Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His
785                 790                 795                 800
Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu
                805                 810                 815
Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu
            820                 825                 830
Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His
        835                 840                 845

<210> 2028
<211> 662
<212> PRT
<213> Homo sapiens

<400> 2028
Met Glu Ser Lys Thr Glu Lys Trp Met Glu Arg Ile His Leu Asn Val
 1               5                  10                  15
Ser Glu Arg Pro Phe Pro Pro His Ile Gln Leu Pro Pro Glu Ile Gln
            20                  25                  30
Glu Ser Gln Glu Val Thr Leu Thr Cys Leu Leu Asn Phe Ser Cys Tyr
        35                  40                  45
Gly Tyr Pro Ile Gln Leu Gln Trp Leu Leu Glu Gly Val Pro Met Arg
    50                  55                  60
Gln Ala Ala Val Thr Ser Thr Ser Leu Thr Ile Lys Ser Val Phe Thr
65                  70                  75                  80
Arg Ser Glu Leu Lys Phe Ser Pro Gln Trp Ser His His Gly Lys Ile
                85                  90                  95
Val Thr Cys Gln Leu Gln Asp Ala Asp Gly Lys Phe Leu Ser Asn Asp
            100                 105                 110
Thr Val Gln Leu Asn Val Lys His Thr Pro Lys Leu Glu Ile Lys Val
        115                 120                 125
Thr Pro Ser Asp Ala Ile Val Arg Glu Gly Asp Ser Val Thr Met Thr
    130                 135                 140
Cys Glu Val Ser Ser Thr Asn Pro Glu Tyr Thr Thr Val Ser Trp Leu
145                 150                 155                 160
Lys Asp Gly Thr Ser Leu Lys Lys Gln Asn Thr Phe Thr Leu Asn Leu
                165                 170                 175
Arg Glu Val Thr Lys Asp Gln Ser Gly Lys Tyr Cys Cys Gln Val Ser
            180                 185                 190
Asn Asp Val Gly Pro Gly Arg Ser Glu Glu Val Phe Leu Gln Val Gln
        195                 200                 205
Tyr Ala Pro Glu Pro Ser Thr Val Gln Ile Leu His Ser Pro Ala Val
    210                 215                 220
Glu Gly Ser Gln Val Glu Phe Leu Cys Met Ser Leu Ala Asn Pro Leu
225                 230                 235                 240
Pro Thr Asn Tyr Thr Trp Tyr His Asn Gly Lys Glu Met Gln Gly Arg
                245                 250                 255
Thr Glu Glu Lys Val His Ile Pro Lys Ile Leu Pro Trp His Ala Gly
            260                 265                 270
Thr Tyr Ser Cys Val Ala Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly
        275                 280                 285
Pro Gly Ala Glu Leu Asp Val Gln Tyr Pro Pro Lys Lys Val Thr Thr
    290                 295                 300
Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu
305                 310                 315                 320
Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp
                325                 330                 335
Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile
            340                 345                 350
Gln Lys Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Arg Cys Asn
        355                 360                 365
Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala
    370                 375                 380
Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His
385                 390                 395                 400
Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro
                405                 410                 415
Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys
            420                 425                 430
Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser
        435                 440                 445
Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala
    450                 455                 460
Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met
465                 470                 475                 480
Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Arg Cys
                485                 490                 495
Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp
            500                 505                 510
Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro
        515                 520                 525
Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser
    530                 535                 540
Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser
545                 550                 555                 560
Pro Glu Thr Ile Gly Arg Arg Val Ala Val Gly Leu Gly Ser Cys Leu
                565                 570                 575
Ala Ile Leu Ile Leu Ala Ile Cys Gly Leu Lys Leu Gln Arg Arg Asp
            580                 585                 590
Ala Glu Ser Ser Glu Met Gln Arg Pro Pro Arg Thr Cys Asp Asp Thr
        595                 600                 605
Val Thr Tyr Ser Ala Leu His Lys Arg Gln Val Gly Asp Tyr Glu Asn
    610                 615                 620
Val Ile Pro Asp Phe Pro Glu Asp Glu Gly Ile His Tyr Ser Glu Leu
625                 630                 635                 640
Ile Gln Phe Gly Val Gly Glu Arg Pro Gln Ala Gln Glu Asn Val Asp
                645                 650                 655
Tyr Val Ile Leu Lys His
            660

<210> 2029
<211> 670
<212> PRT
<213> Homo sapiens

<400> 2029
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu
 1               5                  10                  15
Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu
            20                  25                  30
Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala
        35                  40                  45
Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr
    50                  55                  60
Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr
65                  70                  75                  80
Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly
                85                  90                  95
Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn
            100                 105                 110
Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp
        115                 120                 125
Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His
    130                 135                 140
Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr
145                 150                 155                 160
Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp
                165                 170                 175
Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser
            180                 185                 190
Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro
        195                 200                 205
Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala
    210                 215                 220
Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
225                 230                 235                 240
Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg
                245                 250                 255
Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro
            260                 265                 270
Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro
        275                 280                 285
Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr
    290                 295                 300
Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val
305                 310                 315                 320
Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile
                325                 330                 335
Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys
            340                 345                 350
Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys
        355                 360                 365
Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile
    370                 375                 380
Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile
385                 390                 395                 400
Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro
                405                 410                 415
Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly
            420                 425                 430
Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser
        435                 440                 445
His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser
    450                 455                 460
Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr
465                 470                 475                 480
Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser
                485                 490                 495
Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala
            500                 505                 510
Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly
        515                 520                 525
Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu
    530                 535                 540
Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val
545                 550                 555                 560
Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn
                565                 570                 575
Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu
            580                 585                 590
Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg
        595                 600                 605
Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys
    610                 615                 620
Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp
625                 630                 635                 640
Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg
                645                 650                 655
Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His
            660                 665                 670

<210> 2030
<211> 101
<212> PRT
<213> Homo sapiens

<400> 2030
Arg Pro Phe Pro Pro His Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser
 1               5                  10                  15
Gln Glu Val Thr Leu Thr Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr
            20                  25                  30
Pro Ile Gln Leu Gln Trp Leu Leu Glu Gly Val Pro Met Arg Gln Ala
        35                  40                  45
Ala Val Thr Ser Thr Ser Leu Thr Ile Lys Ser Val Phe Thr Arg Ser
    50                  55                  60
Lys Leu Lys Phe Ser Pro Gln Trp Ser His His Gly Lys Ile Val Thr
65                  70                  75                  80
Cys Gln Leu Gln Asp Ala Asp Gly Lys Phe Leu Ser Asn Asp Thr Val
                85                  90                  95
Gln Leu Asn Val Lys
            100

<210> 2031
<211> 101
<212> PRT
<213> Homo sapiens

<400> 2031
Arg Pro Phe Pro Pro His Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser
 1               5                  10                  15
Gln Glu Val Thr Leu Thr Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr
            20                  25                  30
Pro Ile Gln Leu Gln Trp Leu Leu Glu Gly Val Pro Met Arg Gln Ala
        35                  40                  45
Ala Val Thr Ser Thr Ser Leu Thr Ile Lys Ser Val Phe Thr Arg Ser
    50                  55                  60
Glu Leu Lys Phe Ser Pro Gln Trp Ser His His Gly Lys Ile Val Thr
65                  70                  75                  80
Cys Gln Leu Gln Asp Ala Asp Gly Lys Phe Leu Ser Asn Asp Thr Val
                85                  90                  95
Gln Leu Asn Val Lys
            100

<210> 2032
<211> 241
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(241)
<223> Xaa = Any Amino Acid

<400> 2032
Gly Arg Val Pro Ser Gln Cys Gly Trp Ile Arg Met Arg Ser Arg Ser
 1               5                  10                  15
Cys Arg Glu Asp Gln Lys Pro Gly Met Asp Asp Gln Arg Asp Leu Ile
            20                  25                  30
Ser Asn Asn Glu Gln Leu Ser Met Leu Gly Arg Arg Pro Gly Ala Pro
        35                  40                  45
Glu Ser Lys Cys Ser Arg Gly Cys Pro Leu His Ser Ala Phe Ser Ile
    50                  55                  60
Leu Val Thr Leu Leu Leu Val Val Gln Ala Ile Asn Ala Tyr Phe Leu
65                  70                  75                  80
Tyr His Xaa His Gly Arg Leu Asp Lys Leu Thr Val Thr Pro Gln Asn
                85                  90                  95
Leu Gln Leu Glu Asn Leu Arg Met Lys Leu Pro Lys Pro Pro Lys Pro
            100                 105                 110
Val Ser Lys Met Arg Met Ala Thr Pro Leu Leu Met Gln Ala Leu Pro
        115                 120                 125
Met Gly Ala Leu Pro Gln Gly Pro Met Gln Asn Ala Thr Lys Tyr Gly
    130                 135                 140
Asn Met Thr Glu Asp His Val Met His Leu Leu Gln Asn Ala Asp Pro
145                 150                 155                 160
Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe Pro Glu Asn Leu Arg
                165                 170                 175
His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp Lys Val Phe Glu Ser
            180                 185                 190
Trp Met His His Trp Leu Leu Phe Glu Met Ser Arg His Ser Leu Glu
        195                 200                 205
Gln Lys Pro Thr Asp Ala Pro Pro Lys Glu Ser Leu Glu Leu Glu Asp
    210                 215                 220
Pro Ser Ser Gly Leu Gly Val Thr Lys Gln Asp Leu Gly Pro Val Pro
225                 230                 235                 240
Met


<210> 2033
<211> 184
<212> PRT
<213> Homo sapiens

<400> 2033
Lys Gly Asn Val Asp Leu Val Phe Leu Phe Asp Gly Ser Met Ser Leu
 1               5                  10                  15
Gln Pro Asp Glu Phe Gln Lys Ile Leu Asp Phe Met Lys Asp Val Met
            20                  25                  30
Lys Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala Val Gln Phe Ser
        35                  40                  45
Thr Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr Val Lys Arg Lys
    50                  55                  60
Asp Pro Asp Ala Leu Leu Lys His Val Lys His Met Leu Leu Leu Thr
65                  70                  75                  80
Asn Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu Val Phe Arg Glu
                85                  90                  95
Glu Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu Ile Ile Ile Thr
            100                 105                 110
Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala Ala Lys Asp Ile
        115                 120                 125
Ile Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln Thr Lys Glu Ser
    130                 135                 140
Gln Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala Ser Glu Phe Val
145                 150                 155                 160
Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu Phe Thr Glu Leu
                165                 170                 175
Gln Lys Lys Ile Tyr Val Ile Glu
            180

<210> 2034
<211> 641
<212> PRT
<213> Homo sapiens

<400> 2034
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe
 1               5                  10                  15
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro
            20                  25                  30
Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser
        35                  40                  45
Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys
    50                  55                  60
Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr
65                  70                  75                  80
Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn
                85                  90                  95
Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu
            100                 105                 110
Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr
        115                 120                 125
Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys
    130                 135                 140
Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile
145                 150                 155                 160
Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn
                165                 170                 175
Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu
            180                 185                 190
Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser
        195                 200                 205
Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile
    210                 215                 220
Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg
225                 230                 235                 240
Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg
                245                 250                 255
Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp
            260                 265                 270
Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu
        275                 280                 285
Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala
    290                 295                 300
Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys
305                 310                 315                 320
Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser
                325                 330                 335
Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly
            340                 345                 350
Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val
        355                 360                 365
Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln
    370                 375                 380
Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr
385                 390                 395                 400
Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys
                405                 410                 415
Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala
            420                 425                 430
Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser
        435                 440                 445
Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys
    450                 455                 460
Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr
465                 470                 475                 480
Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe
                485                 490                 495
Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg
            500                 505                 510
Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr
        515                 520                 525
Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser
    530                 535                 540
Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys
545                 550                 555                 560
Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp
                565                 570                 575
Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg
            580                 585                 590
Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met
        595                 600                 605
Glu Glu Gly Thr Arg Ala Phe Gly Glu Cys Cys Cys Lys Asp Leu Thr
    610                 615                 620
Lys His Lys Arg Cys Pro Arg Leu His His Ser Glu Ile Glu His Cys
625                 630                 635                 640
Lys


<210> 2035
<211> 664
<212> PRT
<213> Homo sapiens

<400> 2035
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe
 1               5                  10                  15
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro
            20                  25                  30
Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser
        35                  40                  45
Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys
    50                  55                  60
Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr
65                  70                  75                  80
Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn
                85                  90                  95
Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu
            100                 105                 110
Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr
        115                 120                 125
Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys
    130                 135                 140
Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile
145                 150                 155                 160
Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn
                165                 170                 175
Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu
            180                 185                 190
Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser
        195                 200                 205
Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile
    210                 215                 220
Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg
225                 230                 235                 240
Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg
                245                 250                 255
Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp
            260                 265                 270
Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu
        275                 280                 285
Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala
    290                 295                 300
Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys
305                 310                 315                 320
Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser
                325                 330                 335
Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly
            340                 345                 350
Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val
        355                 360                 365
Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln
    370                 375                 380
Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr
385                 390                 395                 400
Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys
                405                 410                 415
Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala
            420                 425                 430
Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser
        435                 440                 445
Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys
    450                 455                 460
Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr
465                 470                 475                 480
Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe
                485                 490                 495
Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg
            500                 505                 510
Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr
        515                 520                 525
Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser
    530                 535                 540
Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys
545                 550                 555                 560
Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp
                565                 570                 575
Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg
            580                 585                 590
Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met
        595                 600                 605
Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln
    610                 615                 620
His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Lys
625                 630                 635                 640
Lys Lys Lys Lys Ser Asn Trp Lys Arg Gly Asp Ser His Ser Val His
                645                 650                 655
Gln Leu Ala Arg Pro Arg Gly Ala
            660

<210> 2036
<211> 553
<212> PRT
<213> Homo sapiens

<400> 2036
Gln Ser Pro Thr Pro Ser Pro Thr Gly Leu Thr Thr Ala Lys Met Pro
 1               5                  10                  15
Ser Trp Pro Leu Ser Ser Asp Pro Leu Pro Thr His Thr Thr Ala Phe
            20                  25                  30
Ser Pro Ala Ser Thr Phe Glu Arg Glu Asn Asp Phe Ser Glu Thr Thr
        35                  40                  45
Thr Ser Leu Ser Pro Asp Asn Thr Ser Thr Gln Val Ser Pro Asp Ser
    50                  55                  60
Leu Asp Asn Ala Ser Ala Phe Asn Thr Thr Gly Val Ser Ser Val Gln
65                  70                  75                  80
Thr Pro His Leu Pro Thr His Ala Asp Ser Gln Thr Pro Ser Ala Gly
                85                  90                  95
Thr Asp Thr Gln Thr Phe Ser Gly Ser Ala Ala Asx Ala Lys Leu Asn
            100                 105                 110
Pro Thr Pro Gly Ser Asn Ala Ile Ser Asp Val Pro Gly Glu Arg Ser
        115                 120                 125
Thr Ala Ser Thr Phe Pro Thr Asp Pro Val Ser Pro Leu Thr Thr Thr
    130                 135                 140
Leu Ser Leu Ala His His Ser Ser Ala Ala Leu Pro Ala Arg Thr Ser
145                 150                 155                 160
Asn Thr Thr Ile Thr Ala Asn Thr Ser Asp Ala Tyr Leu Asn Ala Ser
                165                 170                 175
Glu Thr Thr Thr Leu Ser Pro Ser Gly Ser Ala Val Ile Ser Thr Thr
            180                 185                 190
Thr Ile Ser Thr Thr Pro Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala
        195                 200                 205
Asn Ile Thr Val Asp Tyr Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr
    210                 215                 220
Ala Lys Leu Asn Val Asn Glu Asn Val Glu Cys Gly Asn Asn Thr Cys
225                 230                 235                 240
Thr Asn Asn Glu Val His Asn Leu Thr Glu Cys Lys Asn Ala Ser Val
                245                 250                 255
Ser Ile Ser His Asn Ser Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu
            260                 265                 270
Asp Val Pro Pro Gly Val Glu Lys Phe Gln Leu His Asp Cys Thr Gln
        275                 280                 285
Val Glu Lys Ala Asp Thr Thr Ile Cys Leu Lys Trp Lys Asn Ile Glu
    290                 295                 300
Thr Phe Thr Cys Asp Thr Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly
305                 310                 315                 320
Asn Met Ile Phe Asp Asn Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro
                325                 330                 335
Glu His Glu Tyr Lys Cys Asp Ser Glu Ile Leu Tyr Asn Asn His Lys
            340                 345                 350
Phe Thr Asn Ala Ser Lys Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly
        355                 360                 365
Glu Pro Gln Ile Ile Phe Cys Arg Ser Glu Ala Ala His Gln Gly Val
    370                 375                 380
Ile Thr Trp Asn Pro Pro Gln Arg Ser Phe His Asn Phe Thr Leu Cys
385                 390                 395                 400
Tyr Ile Lys Glu Thr Glu Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu
                405                 410                 415
Ile Lys Tyr Asp Leu Gln Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu
            420                 425                 430
Ser Leu His Ala Tyr Ile Ile Ala Lys Val Gln Arg Asn Gly Ser Ala
        435                 440                 445
Ala Met Cys His Phe Thr Thr Lys Ser Ala Pro Pro Ser Gln Val Trp
    450                 455                 460
Asn Met Thr Val Ser Met Thr Ser Asp Asn Ser Met His Val Lys Cys
465                 470                 475                 480
Arg Pro Pro Arg Asp Arg Asn Gly Pro His Glu Arg Tyr His Leu Glu
                485                 490                 495
Val Glu Ala Gly Asn Thr Lys Val Arg Asn Glu Ser His Lys Asn Cys
            500                 505                 510
Asp Phe Arg Val Lys Asp Leu Gln Tyr Ser Thr Asp Tyr Thr Phe Lys
        515                 520                 525
Ala Tyr Phe His Asn Gly Asp Tyr Pro Gly Glu Pro Phe Ile Leu His
    530                 535                 540
His Ser Thr Ser Tyr Asn Ser Lys Ala
545                 550

<210> 2037
<211> 139
<212> PRT
<213> Homo sapiens

<400> 2037
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Leu His
65                  70                  75                  80
Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp
                85                  90                  95
Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Thr Gln
            100                 105                 110
Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly
        115                 120                 125
Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser
    130                 135

<210> 2038
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2038
Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val
 1               5                  10                  15
Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu
            20                  25                  30
Cys Lys


<210> 2039
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2039
Leu Cys Leu Val Pro Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr
 1               5                  10                  15
Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn Gly Arg Tyr
            20                  25                  30

<210> 2040
<211> 139
<212> PRT
<213> Homo sapiens

<400> 2040
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Leu His
65                  70                  75                  80
Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp
                85                  90                  95
Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Thr Gln
            100                 105                 110
Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly
        115                 120                 125
Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser
    130                 135

<210> 2041
<211> 524
<212> PRT
<213> Homo sapiens

<400> 2041
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520
