                         SEQUENCE LISTING



<110> Young, Paul

      Horrigan, Stephen

      Weaver, Zoe

      Endress, Gregory



<120>  Cancer-Linked Genes as Targets for Chemotherapy



<130>  689290-79



<150>  US/60/239,294

<151>  2000-10-11



<150>  US/60/239,297

<151>  2000-10-11



<150>  US/60/239,605

<151>  2000-10-11



<150>  US/60/239,802

<151>  2000-10-12



<150>  US/60/239,805

<151>  2000-10-12



<150>  US/60/239,806

<151>  2000-10-12



<150>  US/60/240,622

<151>  2000-10-16



<150>  US/60/241,682

<151>  2000-10-19



<150>  US/60/241,723

<151>  2000-10-19



<150>  US/60/244,932

<151>  2000-10-31



<160>  21    



<170>  PatentIn version 3.0



<210>  1

<211>  1934

<212>  DNA

<213>  Homo sapiens



<400>  1
ctgtcattca tgctttggaa aagtttactg tatatacatt agacattcct gttctttttg     60

gagttagtac tacatcccct gaagaaacat gtgcccaggt gattcgtgaa gctaagagaa    120

cagcaccaag tatagtgtat gttcctcata tccacgtgtg gtgggaaata gttggaccga    180

cacttaaagc cacatttacc acattattac agaatattcc ttcatttgct ccagttttac    240

tacttgcaac ttctgacaaa ccccattccg ctttgccaga agaggtgcaa gaattgttta    300

tccgtgatta tggagagatt tttaatgtcc agttaccgga taaagaagaa cggacaaaat    360

tttttgaaga tttaattcta aaacaagctg ctaagcctcc tatatcaaaa aagaaagcag    420

ttttgcaggc tttggaggta ctcccagtag caccaccacc tgagccaaga tcactgacag    480

cagaagaagt gaaacgacta gaagaacaag aagaagatac atttagagaa ctgaggattt    540

tcttaagaaa tgttacacat aggcttgcta ttgacaagcg attccgagtg tttactaagc    600

ctgttgaccc tgatgaggtt cctgattatg tcactgtaat aaagcaacca atggaccttt    660

catctgtaat cagtaaaatt gatctacaca agtatctgac tgtgaaagac tatttgagag    720

atattgatct aatctgtagt aatgccttag aatacaatcc agatagagat cctggagatc    780

gtcttattag gcatagagcc tgtgctttaa gagatactgc ctatgccata attaaagaag    840

aacttgatga agactttgag cagctctgtg aagaaattca ggaatctaga aagaaaagag    900

gttgtagctc ctccaaatat gccccgtctt actaccatgt gatgccaaag caaaattcca    960

ctcttgttgg tgataaaaga tcagacccag agcagaatga aaagctaaag acaccgagta   1020

ctcctgtggc ttgcagcact cctgctcagt tgaagaggaa aattcgcaaa aagtcaaact   1080

ggtacttagg caccataaaa aagcgaagga agatttcaca ggcaaaggat gatagccaga   1140

atgccataga tcacaaaatt gagagtgata cagaggaaac tcaagacaca agtgtagatc   1200

ataatgagac cggaaacaca ggagagtctt cggtggaaga aaatgaaaaa cagcaaaatg   1260

cctctgaaag caaactggaa ttgagaaata attcaaatac ttgtaatata gagaatgagc   1320

ttgaagactc taggaagact acagcatgta cagaattgag agacaagatt gcttgtaatg   1380

gagatgcttc tagctctcag ataatacata tttctgatga aaatgaagga aaagaaatgt   1440

gtgttctgcg aatgactcga gctagacgtt cccaggtaga acagcagcag ctcatcactg   1500

ttgaaaaggc tttggcaatt ctttctcagc ctacaccctc acttgttgtg gatcatgagc   1560

gattaaaaaa tcttttgaag actgttgtta aaaaaagtca aaactacaac atatttcagt   1620

tggaaaattt gtatgcagta atcagccaat gtatttatcg gcatcgcaag gaccatgata   1680

aaacatcact tattcagaaa atggagcaag aggtagaaaa cttcagttgt tccagatgat   1740

gatgtcatgg tatcgagtat tctttatatt cagttcctat ttaagtcatt tttgtcatgt   1800

ccgcctaatt gatgtagtat gaaaccctgc atctttaagg aaaagattaa aatagtaaaa   1860

taaaagtatt taaactttcc tgatatttat gtacatatta agataaatgt catgtgtaag   1920

ataactgata aata                                                     1934


<210>  2

<211>  362

<212>  PRT

<213>  Homo sapiens



<400>  2

Met Asp Leu Ser Ser Val Ile Ser Lys Ile Asp Leu His Lys Tyr Leu 
1               5                   10                  15      

Thr Val Lys Asp Tyr Leu Arg Asp Ile Asp Leu Ile Cys Ser Asn Ala 
            20                  25                  30          

Leu Glu Tyr Asn Pro Asp Arg Asp Pro Gly Asp Arg Leu Ile Arg His 
        35                  40                  45              

Arg Ala Cys Ala Leu Arg Asp Thr Ala Tyr Ala Ile Ile Lys Glu Glu 
    50                  55                  60                  

Leu Asp Glu Asp Phe Glu Gln Leu Cys Glu Glu Ile Gln Glu Ser Arg 
65                  70                  75                  80  

Lys Lys Arg Gly Cys Ser Ser Ser Lys Tyr Ala Pro Ser Tyr Tyr His 
                85                  90                  95      

Val Met Pro Lys Gln Asn Ser Thr Leu Val Gly Asp Lys Arg Ser Asp 
            100                 105                 110         

Pro Glu Gln Asn Glu Lys Leu Lys Thr Pro Ser Thr Pro Val Ala Cys 
        115                 120                 125             

Ser Thr Pro Ala Gln Leu Lys Arg Lys Ile Arg Lys Lys Ser Asn Trp 
    130                 135                 140                 

Tyr Leu Gly Thr Ile Lys Lys Arg Arg Lys Ile Ser Gln Ala Lys Asp 
145                 150                 155                 160 

Asp Ser Gln Asn Ala Ile Asp His Lys Ile Glu Ser Asp Thr Glu Glu 
                165                 170                 175     

Thr Gln Asp Thr Ser Val Asp His Asn Glu Thr Gly Asn Thr Gly Glu 
            180                 185                 190         

Ser Ser Val Glu Glu Asn Glu Lys Gln Gln Asn Ala Ser Glu Ser Lys 
        195                 200                 205             

Leu Glu Leu Arg Asn Asn Ser Asn Thr Cys Asn Ile Glu Asn Glu Leu 
    210                 215                 220                 

Glu Asp Ser Arg Lys Thr Thr Ala Cys Thr Glu Leu Arg Asp Lys Ile 
225                 230                 235                 240 

Ala Cys Asn Gly Asp Ala Ser Ser Ser Gln Ile Ile His Ile Ser Asp 
                245                 250                 255     

Glu Asn Glu Gly Lys Glu Met Cys Val Leu Arg Met Thr Arg Ala Arg 
            260                 265                 270         

Arg Ser Gln Val Glu Gln Gln Gln Leu Ile Thr Val Glu Lys Ala Leu 
        275                 280                 285             

Ala Ile Leu Ser Gln Pro Thr Pro Ser Leu Val Val Asp His Glu Arg 
    290                 295                 300                 

Leu Lys Asn Leu Leu Lys Thr Val Val Lys Lys Ser Gln Asn Tyr Asn 
305                 310                 315                 320 

Ile Phe Gln Leu Glu Asn Leu Tyr Ala Val Ile Ser Gln Cys Ile Tyr 
                325                 330                 335     

Arg His Arg Lys Asp His Asp Lys Thr Ser Leu Ile Gln Lys Met Glu 
            340                 345                 350         

Gln Glu Val Glu Asn Phe Ser Cys Ser Arg 
        355                 360         

<210>  3

<211>  1274

<212>  DNA

<213>  Homo sapiens



<400>  3
cacgaggcag actgaagatt gtggcttggt attcacaggc aggtttcaga catttagatc     60

tttcttttaa tgactaacac catgcctatc tgtggagaag ctggcaacat gtcacacctg    120

gaaattgttt ttcaacatta atactattat ttggcagtaa tccagattgc ttttgccacc    180

aacctgaaga catatagagg cagaaggaca ggaataattc tatttgtttc ctgttttgaa    240

acttccatct gtaaggctat caaaaggaga tgtgagagag ggtattgagt ctggcctgac    300

aatgcagttc ttaaaccaaa ggtccattat gcttctcctc tctgagaatc ctgacttacc    360

tcaacaacgg agacatggca cagtagccag cttggagact tctcagccaa tgctctgaga    420

tcaagtcgaa gacccaatat acagggtttt gagctcatct tcatcattca tatgaggaaa    480

taagtggtaa aatccttgga aatacaatga gactcatcag aaacatttac atattttgta    540

gtattgttat gacagcagag ggtgatgctc cagagctgcc agaagaaagg gaactgatga    600

ccaactgctc caacatgtct ctaagaaagg ttcccgcaga cttgacccca gccacaacga    660

cactggattt atcctataac ctcctttttc aactccagag ttcagatttt cattctgtct    720

ccaaactgag agttttgatt ctatgccata acagaattca acagctggat ctcaaaacct    780

ttgaattcaa caaggagtta agatatttag atttgtctaa taacagactg aagagtgtaa    840

cttggtattt actggcaggt ctcaggtatt tagatctttc ttttaatgac tttgacacca    900

tgcctatctg tgaggaagct ggcaacatgt cacacctgga aatcctaggt ttgagtgggg    960

caaaaataca aaaatcagat ttccagaaaa ttgctcatct gcatctaaat actgtcttct   1020

taggattcag aactcttcct cattatgaag aaggtagcct gcccatctta aacacaacaa   1080

aactgcacat tgttttacca atggacacaa atttctgggt tcttttgcgt gatggaatca   1140

agacttcaaa aatattagaa atgacaaata tagatggcaa aagccaattt gtaagttatg   1200

aaatgcaacg aaatcttagt ttagaacatg ctaagacatc ggttctattg cttaataaag   1260

ttgatttact ctgg                                                     1274


<210>  4

<211>  256

<212>  PRT

<213>  Homo sapiens



<400>  4

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      

Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          

Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              

Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  

Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  

His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      

Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         

Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             

Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 

Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 

Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     

Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         

Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             

Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 

Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 

His Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     

<210>  5

<211>  814

<212>  DNA

<213>  Homo sapiens



<400>  5
agaatcccgg acagccctgc tccctgcagc caggtgtagt ttcgggagcc actggggcca     60

aagtgagagt ccagcggtct tccagcgctt gggccacggc ggcggccctg ggagcagagg    120

tggagcgacc ccattacgct aaagatgaaa ggctggggtt ggctggccct gcttctgggg    180

gccctgctgg gaaccgcctg ggctcggagg agccaggatc tccactgtgg agcatgcagg    240

gctctggtgg atgaactaga atgggaaatt gcccaggtgg accccaagaa gaccattcag    300

atgggatctt tccggatcaa tccagatggc agccagtcag tggtggaggt gccttatgcc    360

cgctcagagg cccacctcac agagctgctg gaggagatat gtgaccggat gaaggagtat    420

ggggaacaga ttgatccttc cacccatcgc aagaactacg tacgtgtagt gggccggaat    480

ggagaatcca gtgaactgga cctacaaggc atccgaatcg actcagatat tagcggcacc    540

ctcaagtttg cgtgtgagag cattgtggag gaatacgagg atgaactcat tgaattcttt    600

tcccgagagg ctgacaatgt taaagacaaa ctttgcagta agcgaacaga tctttgtgac    660

catgccctgc acatatcgca tgatgagcta tgaaccactg gagcagccca cactggcttg    720

atggatcacc cccaggaggg gaaaatggtg gcaatgcctt ttatatatta tgtttttact    780

gaaattaact gaaaaaatat gaaaccaaaa gtac                                814


<210>  6

<211>  182

<212>  PRT

<213>  Homo sapiens



<400>  6

Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      

Thr Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          

Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              

Lys Thr Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  

Ser Val Val Glu Val Pro Tyr Ala Arg Ser Glu Ala His Leu Thr Glu 
65                  70                  75                  80  

Leu Leu Glu Glu Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile 
                85                  90                  95      

Asp Pro Ser Thr His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn 
            100                 105                 110         

Gly Glu Ser Ser Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp 
        115                 120                 125             

Ile Ser Gly Thr Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr 
    130                 135                 140                 

Glu Asp Glu Leu Ile Glu Phe Phe Ser Arg Glu Ala Asp Asn Val Lys 
145                 150                 155                 160 

Asp Lys Leu Cys Ser Lys Arg Thr Asp Leu Cys Asp His Ala Leu His 
                165                 170                 175     

Ile Ser His Asp Glu Leu 
            180         

<210>  7

<211>  1597

<212>  DNA

<213>  Homo sapiens



<400>  7
gcggccgctg cgccgcaaac tcgtgtggga cgcaccgctc cagccgcccg cgggccagcg     60

caccggtccc ccagcggcag ccgagcccgc ccgcgcgccg ttcgtgccct cgtgaggctg    120

gcatgcagga tggcaggaca gcccggccac atgccccatg gagggagttc caacaacctc    180

tgccacaccc tggggcctgt gcatcctcct gacccacaga ggcatcccaa cacgctgtct    240

tttcgctgct cgctggcgga cttccagatc gaaaagaaga taggccgagg acagttcagc    300

gaggtgtaca aggccacctg cctgctggac aggaagacag tggctctgaa gaaggtgcag    360

atctttgaga tgatggacgc caaggcgagg caggactgtg tcaaggagat cggcctcttg    420

aagcaactga accacccaaa tatcatcaag tatttggact cgtttatcga agacaacgag    480

ctgaacattg tgctggagtt ggctgacgca ggggacctct cgcagatgat caagtacttt    540

aagaagcaga agcggctcat cccggagagg acagtatgga agtactttgt gcagctgtgc    600

agcgccgtgg agcacatgca ttcacgccgg gtgatgcacc gagacatcaa gcctgccaac    660

gtgttcatca cagccacggg cgtcgtgaag ctcggtgacc ttggtctggg ccgcttcttc    720

agctctgaga ccaccgcagc ccactcccta gtggggacgc cctactacat gtcaccggag    780

aggatccatg agaacggcta caacttcaag tccgacatct ggtccttggg ctgtctgctg    840

tacgagatgg cagccctcca gagccccttc tatggagata agatgaatct cttctccctg    900

tgccagaaga tcgagcagtg tgactacccc ccactccccg gggagcacta ctccgagaag    960

ttacgagaac tggtcagcat gtgcatctgc cctgaccccc accagagacc tgacatcgga   1020

tacgtgcacc aggtggccaa gcagatgcac atctggatgt ccagcacctg agcgtggatg   1080

caccgtgcct tatcaaagcc agcaccactt tgccttactt gagtcgtctt ctcttcgagt   1140

ggccacctgg tagcctagaa cagctaagac cacagggttc agcaggttcc ccaaaaggct   1200

gcccagcctt acagcagatg ctgaaggcag agcagctgag ggaggggcgc tggccacatg   1260

tcactgatgg tcagattcca aagtcctttc tttatactgt tgtggacaat ctcagctggg   1320

tcaataaggg caggtggttc agcgagccac ggcagccccc tgtatctgga ttgtaatgtg   1380

aatctttagg gtaattcctc cagtgacctg tcaaggctta tgctaacagg agacttgcag   1440

gagaccgtgt gatttgtgta gtgagccttt gaaaatggtt agtaccgggt tcagtttagt   1500

tcttggtatc ttttcaatca agctgtgtgc ttaatttact ctgttgtaaa gggataaagt   1560

ggaaatcatt tttttccgtg gaaaaaaaaa aaaaaaa                            1597


<210>  8

<211>  306

<212>  PRT

<213>  Homo sapiens



<400>  8

Met Pro His Gly Gly Ser Ser Asn Asn Leu Cys His Thr Leu Gly Pro 
1               5                   10                  15      

Val His Pro Pro Asp Pro Gln Arg His Pro Asn Thr Leu Ser Phe Arg 
            20                  25                  30          

Cys Ser Leu Ala Asp Phe Gln Ile Glu Lys Lys Ile Gly Arg Gly Gln 
        35                  40                  45              

Phe Ser Glu Val Tyr Lys Ala Thr Cys Leu Leu Asp Arg Lys Thr Val 
    50                  55                  60                  

Ala Leu Lys Lys Val Gln Ile Phe Glu Met Met Asp Ala Lys Ala Arg 
65                  70                  75                  80  

Gln Asp Cys Val Lys Glu Ile Gly Leu Leu Lys Gln Leu Asn His Pro 
                85                  90                  95      

Asn Ile Ile Lys Tyr Leu Asp Ser Phe Ile Glu Asp Asn Glu Leu Asn 
            100                 105                 110         

Ile Val Leu Glu Leu Ala Asp Ala Gly Asp Leu Ser Gln Met Ile Lys 
        115                 120                 125             

Tyr Phe Lys Lys Gln Lys Arg Leu Ile Pro Glu Arg Thr Val Trp Lys 
    130                 135                 140                 

Tyr Phe Val Gln Leu Cys Ser Ala Val Glu His Met His Ser Arg Arg 
145                 150                 155                 160 

Val Met His Arg Asp Ile Lys Pro Ala Asn Val Phe Ile Thr Ala Thr 
                165                 170                 175     

Gly Val Val Lys Leu Gly Asp Leu Gly Leu Gly Arg Phe Phe Ser Ser 
            180                 185                 190         

Glu Thr Thr Ala Ala His Ser Leu Val Gly Thr Pro Tyr Tyr Met Ser 
        195                 200                 205             

Pro Glu Arg Ile His Glu Asn Gly Tyr Asn Phe Lys Ser Asp Ile Trp 
    210                 215                 220                 

Ser Leu Gly Cys Leu Leu Tyr Glu Met Ala Ala Leu Gln Ser Pro Phe 
225                 230                 235                 240 

Tyr Gly Asp Lys Met Asn Leu Phe Ser Leu Cys Gln Lys Ile Glu Gln 
                245                 250                 255     

Cys Asp Tyr Pro Pro Leu Pro Gly Glu His Tyr Ser Glu Lys Leu Arg 
            260                 265                 270         

Glu Leu Val Ser Met Cys Ile Cys Pro Asp Pro His Gln Arg Pro Asp 
        275                 280                 285             

Ile Gly Tyr Val His Gln Val Ala Lys Gln Met His Ile Trp Met Ser 
    290                 295                 300                 

Ser Thr 
305     

<210>  9

<211>  6780

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<223>  n=a,t,g or c



<400>  9
gggcggggct gagggcggcg ggggcgggcc gcccgagctg ggagggcggc ggcgccgagg     60

ggaggagagc ggcccatgga cccgcggggc ccggcgcccc agactctgcg ccgtcgggac    120

ggagcccaag atgtcggcct aggccggggc gcgacgacgc ggacggggcg gcgaggaggc    180

gccgctgctg ccggggctcg cagccgccga gcccccgagg gcgcgccctg acggactggc    240

cgagccggcg gtgagaggcc ggcgcgtctg gagcgggccg cgcggcacca tgtcggccaa    300

ggtgcggctc aagaagctgg agcagctgct cctggacggg ccctggcgca acgagagcgc    360

cctgagcgtg gaaacgctgc tcgacgtgct cgtctgcctg tacaccgagt gcagccactc    420

ggccctgcgc cgcgacaagt acgtggccga gttcctcgag tgggctaaac catttacaca    480

gctggtgaaa gaaatgcagc ttcatcgaga agactttgaa ataattaaag taattggaag    540

aggtgctttt ggtgaggttg ctgttgtcaa aatgaagaat actgaacgaa tttatgcaat    600

gaaaatcctc aacaagtggg agatgctgaa aagagcagag accgcgtgct tccgagagga    660

gcgcgatgtg ctggtgaacg gcgactgcca gtggatcacc gcgctgcact acgcctttca    720

ggacgagaac cacctgtact tagtcatgga ttactatgtg ggtggtgatt tactgaccct    780

gctcagcaaa tttgaagaca agcttccgga agatatggcg aggttctaca ttggtgaaat    840

ggtgctggcc attgactcca tccatcagct tcattacgtg cacagagaca ttaaacctga    900

caatgtcctt ttggacgtga atggtcatat ccgcctggct gactttggat catgtttgaa    960

gatgaatgat gatggcactg tgcagtcctc cgtggccgtg ggcacacctg actacatctc   1020

gccggagatc ctgcaggcga tggaggacgg catgggcaaa tacgggcctg agtgtgactg   1080

gtggtctctg ggtgtctgca tgtatgagat gctctatgga gaaacgccgt tttatgcgga   1140

gtcactcgtg gagacctatg ggaagatcat gaaccatgaa gagcgattcc agttcccatc   1200

ccatgtcacg gatgtatctg aagaagcgaa ggacctcatc cagagactga tctgcagtag   1260

agaacgccgg ctggggcaga atggaataga ggatttcaaa aagcatgcgt tttttgaagg   1320

tctaaattgg gaaaatatac gaaacctaga agcaccttat attcctgatg tgagcagtcc   1380

ctctgacaca tccaacttcg acgtggatga cgacgtgctg agaaacacgg aaatattacc   1440

tcctggttct cacacaggct tttctggatt acatttgcca ttcattggtt ttacattcac   1500

aacggaaagc tgtttttctg atcgaggctc tctgaagagc ataatgcagt ccaacacatt   1560

aaccaaagat gaggatgtgc agcgggacct ggagcacagc ctgcagatgg aagcttacga   1620

gaggaggatt cggaggctgg aacaggagaa gctggagctg agcaggaagc tgcaagagtc   1680

cacccagacc gtgcagtccc tccacggctc atctcgggcc ctcagcaatt caaaccgaga   1740

taaagaaatc aaaaagctaa atgaagaaat cgaacgcttg aagaataaaa tagcagattc   1800

aaacaggctg gagcgacagc ttgaggacac agtggcgctt cgccaagagc gtgaggactc   1860

cacgcagcgg ctgcgggggc tggagaagca gcaccgcgtg gtccggcagg agaaggagga   1920

gctgcacaag caactggttg aagcctcaga gcggttgaaa tcccaggcca aggaactcaa   1980

agatgcccat cagcagcgaa agctggccct gcaggagttc tcggagctga acgagcgcat   2040

ggcagagctc cgtgcccaga agcagaaggt gtcccggcag ctgcgagaca aggaggagga   2100

gatggaggtg gccacgcaga aggtggacgc catgcggcag gaaatgcgga gagctgagaa   2160

gctcaggaaa gagctggaag ctcagcttga tgatgctgtt gctgaggcct ccaaggagcg   2220

caagcttcgt gagcacagcg agaacttctg caagcaaatg gaaagcgagc tggaggccct   2280

caaggtgaag caaggaggcc ggggagcggg tgccacctta gagcaccagc aagagatttc   2340

caaaatcaaa tccgagctgg agaagaaagt cttattttat gaagaggaat tggtcagacg   2400

tgaggcctcc catgtgctag aagtgaaaaa tgtgaagaag gaggtgcatg attcagaaag   2460

ccaccagctg gccctgcaga aagaaatctt gatgttaaaa gataagttag aaaagtcaaa   2520

gcgagaacgg cataacgaga tggaggaggc agtaggtaca ataaaagata aatacgaacg   2580

agaaagagcg atgctgtttg atgaaaacaa gaagctaact gctgaaaatg aaaagctctg   2640

ttcctttgtg gataaactca cagctcaaaa tagacagctg gaggatgagc tgcaggatct   2700

ggcagccaag aaggagtcag tggcccactg ggaagctcag attgcggaaa tcattcagtg   2760

ggtcagtgac gagaaagatg cccggggtta ccttcaagct cttgcttcca agatgaccga   2820

agagctcgag gctttgagga gttctagtct ggggtcaaga acactggacc cgctgtggaa   2880

ggtgcgccgc agccagaagc tggacatgtc cgcgcggctg gagctgcagt cggccctgga   2940

ggcggagatc cgggccaagc agcttgtcca ggaggagctc aggaaggtca aggacgccaa   3000

cctcaccttg gaaagcaaac taaaggattc cgaagccaaa aacagagaat tattagaaga   3060

aatggaaatt ttgaagaaaa agatggaaga aaaattcaga gcagatactg ggctcaaact   3120

tccagatttt caggattcca tttttgagta tttcaacact gctcctcttg cacatgacct   3180

gacatttaga accagctcag ctagtgagca agaaacacaa gctccgaagc cagaagcgtc   3240

cccgtcgatg tctgtggctg catcagagca gcaggaggac atggctcggc ccccgcagag   3300

gccatccgct gtgccgttgc ccaccacgca ggccctggtt ctggctggac cgaagccaaa   3360

agctcaccag ttcagcatca agtccttctc cagccctact cagtgcagcc actgcacctc   3420

cctgatggtt gggctgatcc ggcagggcta cgcctgcgag gtgtgttcct ttgcttgcca   3480

cgtgtcctgc aaagacggtg ccccccaggt gtgcccaata cctcccgagc agtccaagag   3540

gcctctgggc gtggacgtgc agcgaggcat cggaacagcc tacaaaggcc atgtcaaggt   3600

cccaaagccc acgggggtga agaagggatg gcagcgcgca tatgcagtcg tctgtgagtg   3660

caagctcttc ctgtatgatc tgcctgaagg aaaatccacc cagcctggtg tcattgcgag   3720

ccaagtcttg gatctcagag atgacgagtt ttccgtgagc tcagtcctgg cctcagatgt   3780

cattcatgct acacgccgag atattccatg tatattcagg gtgacggcct ctctcttagg   3840

tgcaccttct aagaccagct cgctgctcat tctgacagaa aatgagaatg aaaagaggaa   3900

gtgggttggg attctagaag gactccagtc catccttcat aaaaaccggc tgaggaatca   3960

ggtcgtgcat gttcccttgg aagcctacga cagctcgctg cctctcatca aggccatcct   4020

gacagctgcc atcgtggatg cagacaggat tgcagtcggc ctagaagaag ggctctatgt   4080

catagaggtc acccgagatg tgatcgtccg tgccgctgac tgtaagaagg tacaccagat   4140

cgagcttgct cccagggaga agatcgtaat cctcctctgt ggccggaacc accatgtgca   4200

cctctatccg tggtcgtccc ttgatggagc ggaaggcagc tttgacatca agcttccgga   4260

aaccaaaggc tgccagctca tggccacggc cacactcaag aggaactctg gcacctgcct   4320

gtttgtggcc gtgaaacggc tgatcctttg ctatgagatc cagagaacga agccattcca   4380

cagaaagttc aatgagattg tggctcccgg cagcgtgcag tgcctggcgg tgctcaggga   4440

caggctctgt gtgggctacc cttctgggtt ctgcctgctg agcatccagg gggacgggca   4500

gcctctaaac ctggtaaatc ccaatgaccc ctcgcttgcg ttcctctcac aacagtcttt   4560

tgatgccctt tgtgctgtgg agctcgaaag cgaggagtac ctgctttgct tcagccacat   4620

gggactgtac gtggacccgc aaggccggag ggcacgcgcg caggagctca tgtggcctgc   4680

ggctcctgtc gcctgtagtt gcagccccac ccacgtcacg gtgtacagcg agtatggcgt   4740

ggacgtcttt gatgtgcgca ccatggagtg ggtgcagacc atcggcctgc ggaggataag   4800

gcccctgaac tctgaaggca ccctcaacct cctcaactgc gagcctccac gcttgatcta   4860

cttcaagagc aagttctcgg gagcggttct caacgtgccg gacacctccg acaacagcaa   4920

gaagcagatg ctgcgcacca ggagcaaaag gcggttcgtc ttcaaggtcc cagaggaaga   4980

gagactgcag cagaggcgag agatgcttag agacccagaa ttgagatcca aaatgatatc   5040

caacccaacc aacttcaacc acgtggccca catgggccca ggcgacggca tgcaggtgct   5100

catggacctg cctctgagtg ctgtgccccc ctcccaggag gaaaggccgg gccccgctcc   5160

caccaacctg gctcgccagc ctccatccag gaacaagccc tacatctcgt ggccctcatc   5220

aggtggatcg gagcctagcg tgactgtgcc tctgagaagt atgtctgatc cagaccagga   5280

ctttgacaaa gagcctgatt cggactccac caaacactca actccatcga atagctccaa   5340

ccccagcggc ccaccgagcc ccaactcccc ccacaggagc cagctccccc tcgaaggcct   5400

ggagcagccg gcctgtgaca cctgaagccg ccagctcgcc acaggggcca gggagctgga   5460

gatggcctcc agcgtcagtg ccaagactga gcgggccctc cagtgttgtc caaggaaatg   5520

tagaatcact ttgtagatat ggagatgaag aagacaaatc tttattataa tattgatcag   5580

ttttatgccg cattgttcgt ggcagtagac cacatctgtt cgtctgcaca gctgtgaggc   5640

gatgctgttc catctgcaca tgaaggaccc ccatacagcc tgtctcccac ccctgacaac   5700

ccgagagggc atatggggcc ctgccaacac cacttcctca gcagaaaccc gtcatgacgc   5760

ggctgcttcg gaagcagaca tctggggaca cagcctcagt acccagtctt ttccctagtt   5820

cctgaaactt tcctaggacc ttaagagaat agtaggaggt cctatagcat tcccagtgtc   5880

actagaattt tgaagacagg aaagtggagg ttagtctgtg gccttttttt catttagcca   5940

ttgcacagtc agctgcagaa gtcctgctga ccacctagtc atggacaaag gcccaggacc   6000

agtgacaccc tgcgtccctg tgtgcgttaa gttcattctg ggtcgcagcc atgaagtgtc   6060

accagtatct actactgtga agtcagctgt gctgttttcc attcgcttcc acggcttctg   6120

cctcctgcca taaaaccagc gagtgtcgtg gtgcaggcag gccctgtggc ctgctgggct   6180

gagggaagtc agagccccag ggcgccacga agcagccact gggatacccc accccgcccc   6240

gccnnccccc ccccccccnc cagtcnagnc ccgaaatgga gcccccgtga ttagtagccc   6300

gtatgatcac gtagacccac ccaacacact cctgcacact ggccccggcc cacggcacag   6360

caatcccctg cgcgtggatt tcacctcacc ctttgtacca gatgttgagt gaccagctct   6420

gtggccctgt gtcgtcagag gcttgtgatt aactgtggcg gcagacacag cttgtccaca   6480

gcttgggcca ggcttcccct gtcctcccac cggtcggctg cttggcaagg ctgttcagga   6540

cgtgcacttc cccaagtcgg cactgagtgg cccagcacca cctagccctg ccaccccact   6600

gccctcctgg gccttctgct ggatgggcac ctggggggtt ctggtttttt acttttttaa   6660

tgtaagtctc agtctttgta attaattatt gaattgtgag aacatttttg aacaatttac   6720

ctgtcaataa agcagaagac ggcagtttta aagttaaaaa aaaaaaaaaa aaaaaaaaaa   6780


<210>  10

<211>  1711

<212>  PRT

<213>  Homo sapiens



<400>  10

Met Ser Ala Lys Val Arg Leu Lys Lys Leu Glu Gln Leu Leu Leu Asp 
1               5                   10                  15      

Gly Pro Trp Arg Asn Glu Ser Ala Leu Ser Val Glu Thr Leu Leu Asp 
            20                  25                  30          

Val Leu Val Cys Leu Tyr Thr Glu Cys Ser His Ser Ala Leu Arg Arg 
        35                  40                  45              

Asp Lys Tyr Val Ala Glu Phe Leu Glu Trp Ala Lys Pro Phe Thr Gln 
    50                  55                  60                  

Leu Val Lys Glu Met Gln Leu His Arg Glu Asp Phe Glu Ile Ile Lys 
65                  70                  75                  80  

Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Met Lys 
                85                  90                  95      

Asn Thr Glu Arg Ile Tyr Ala Met Lys Ile Leu Asn Lys Trp Glu Met 
            100                 105                 110         

Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val Leu 
        115                 120                 125             

Val Asn Gly Asp Cys Gln Trp Ile Thr Ala Leu His Tyr Ala Phe Gln 
    130                 135                 140                 

Asp Glu Asn His Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly Asp 
145                 150                 155                 160 

Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Lys Leu Pro Glu Asp Met 
                165                 170                 175     

Ala Arg Phe Tyr Ile Gly Glu Met Val Leu Ala Ile Asp Ser Ile His 
            180                 185                 190         

Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Val Leu Leu 
        195                 200                 205             

Asp Val Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu Lys 
    210                 215                 220                 

Met Asn Asp Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr Pro 
225                 230                 235                 240 

Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Met Gly 
                245                 250                 255     

Lys Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met Tyr 
            260                 265                 270         

Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val Glu 
        275                 280                 285             

Thr Tyr Gly Lys Ile Met Asn His Glu Glu Arg Phe Gln Phe Pro Ser 
    290                 295                 300                 

His Val Thr Asp Val Ser Glu Glu Ala Lys Asp Leu Ile Gln Arg Leu 
305                 310                 315                 320 

Ile Cys Ser Arg Glu Arg Arg Leu Gly Gln Asn Gly Ile Glu Asp Phe 
                325                 330                 335     

Lys Lys His Ala Phe Phe Glu Gly Leu Asn Trp Glu Asn Ile Arg Asn 
            340                 345                 350         

Leu Glu Ala Pro Tyr Ile Pro Asp Val Ser Ser Pro Ser Asp Thr Ser 
        355                 360                 365             

Asn Phe Asp Val Asp Asp Asp Val Leu Arg Asn Thr Glu Ile Leu Pro 
    370                 375                 380                 

Pro Gly Ser His Thr Gly Phe Ser Gly Leu His Leu Pro Phe Ile Gly 
385                 390                 395                 400 

Phe Thr Phe Thr Thr Glu Ser Cys Phe Ser Asp Arg Gly Ser Leu Lys 
                405                 410                 415     

Ser Ile Met Gln Ser Asn Thr Leu Thr Lys Asp Glu Asp Val Gln Arg 
            420                 425                 430         

Asp Leu Glu His Ser Leu Gln Met Glu Ala Tyr Glu Arg Arg Ile Arg 
        435                 440                 445             

Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu Ser 
    450                 455                 460                 

Thr Gln Thr Val Gln Ser Leu His Gly Ser Ser Arg Ala Leu Ser Asn 
465                 470                 475                 480 

Ser Asn Arg Asp Lys Glu Ile Lys Lys Leu Asn Glu Glu Ile Glu Arg 
                485                 490                 495     

Leu Lys Asn Lys Ile Ala Asp Ser Asn Arg Leu Glu Arg Gln Leu Glu 
            500                 505                 510         

Asp Thr Val Ala Leu Arg Gln Glu Arg Glu Asp Ser Thr Gln Arg Leu 
        515                 520                 525             

Arg Gly Leu Glu Lys Gln His Arg Val Val Arg Gln Glu Lys Glu Glu 
    530                 535                 540                 

Leu His Lys Gln Leu Val Glu Ala Ser Glu Arg Leu Lys Ser Gln Ala 
545                 550                 555                 560 

Lys Glu Leu Lys Asp Ala His Gln Gln Arg Lys Leu Ala Leu Gln Glu 
                565                 570                 575     

Phe Ser Glu Leu Asn Glu Arg Met Ala Glu Leu Arg Ala Gln Lys Gln 
            580                 585                 590         

Lys Val Ser Arg Gln Leu Arg Asp Lys Glu Glu Glu Met Glu Val Ala 
        595                 600                 605             

Thr Gln Lys Val Asp Ala Met Arg Gln Glu Met Arg Arg Ala Glu Lys 
    610                 615                 620                 

Leu Arg Lys Glu Leu Glu Ala Gln Leu Asp Asp Ala Val Ala Glu Ala 
625                 630                 635                 640 

Ser Lys Glu Arg Lys Leu Arg Glu His Ser Glu Asn Phe Cys Lys Gln 
                645                 650                 655     

Met Glu Ser Glu Leu Glu Ala Leu Lys Val Lys Gln Gly Gly Arg Gly 
            660                 665                 670         

Ala Gly Ala Thr Leu Glu His Gln Gln Glu Ile Ser Lys Ile Lys Ser 
        675                 680                 685             

Glu Leu Glu Lys Lys Val Leu Phe Tyr Glu Glu Glu Leu Val Arg Arg 
    690                 695                 700                 

Glu Ala Ser His Val Leu Glu Val Lys Asn Val Lys Lys Glu Val His 
705                 710                 715                 720 

Asp Ser Glu Ser His Gln Leu Ala Leu Gln Lys Glu Ile Leu Met Leu 
                725                 730                 735     

Lys Asp Lys Leu Glu Lys Ser Lys Arg Glu Arg His Asn Glu Met Glu 
            740                 745                 750         

Glu Ala Val Gly Thr Ile Lys Asp Lys Tyr Glu Arg Glu Arg Ala Met 
        755                 760                 765             

Leu Phe Asp Glu Asn Lys Lys Leu Thr Ala Glu Asn Glu Lys Leu Cys 
    770                 775                 780                 

Ser Phe Val Asp Lys Leu Thr Ala Gln Asn Arg Gln Leu Glu Asp Glu 
785                 790                 795                 800 

Leu Gln Asp Leu Ala Ala Lys Lys Glu Ser Val Ala His Trp Glu Ala 
                805                 810                 815     

Gln Ile Ala Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp Ala Arg 
            820                 825                 830         

Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu Leu Glu Ala 
        835                 840                 845             

Leu Arg Ser Ser Ser Leu Gly Ser Arg Thr Leu Asp Pro Leu Trp Lys 
    850                 855                 860                 

Val Arg Arg Ser Gln Lys Leu Asp Met Ser Ala Arg Leu Glu Leu Gln 
865                 870                 875                 880 

Ser Ala Leu Glu Ala Glu Ile Arg Ala Lys Gln Leu Val Gln Glu Glu 
                885                 890                 895     

Leu Arg Lys Val Lys Asp Ala Asn Leu Thr Leu Glu Ser Lys Leu Lys 
            900                 905                 910         

Asp Ser Glu Ala Lys Asn Arg Glu Leu Leu Glu Glu Met Glu Ile Leu 
        915                 920                 925             

Lys Lys Lys Met Glu Glu Lys Phe Arg Ala Asp Thr Gly Leu Lys Leu 
    930                 935                 940                 

Pro Asp Phe Gln Asp Ser Ile Phe Glu Tyr Phe Asn Thr Ala Pro Leu 
945                 950                 955                 960 

Ala His Asp Leu Thr Phe Arg Thr Ser Ser Ala Ser Glu Gln Glu Thr 
                965                 970                 975     

Gln Ala Pro Lys Pro Glu Ala Ser Pro Ser Met Ser Val Ala Ala Ser 
            980                 985                 990         

Glu Gln Gln Glu Asp Met Ala Arg  Pro Pro Gln Arg Pro  Ser Ala Val 
        995                 1000                 1005             

Pro Leu  Pro Thr Thr Gln Ala  Leu Val Leu Ala Gly  Pro Lys Pro 
    1010                 1015                 1020             

Lys Ala  His Gln Phe Ser Ile  Lys Ser Phe Ser Ser  Pro Thr Gln 
    1025                 1030                 1035             

Cys Ser  His Cys Thr Ser Leu  Met Val Gly Leu Ile  Arg Gln Gly 
    1040                 1045                 1050             

Tyr Ala  Cys Glu Val Cys Ser  Phe Ala Cys His Val  Ser Cys Lys 
    1055                 1060                 1065             

Asp Gly  Ala Pro Gln Val Cys  Pro Ile Pro Pro Glu  Gln Ser Lys 
    1070                 1075                 1080             

Arg Pro  Leu Gly Val Asp Val  Gln Arg Gly Ile Gly  Thr Ala Tyr 
    1085                 1090                 1095             

Lys Gly  His Val Lys Val Pro  Lys Pro Thr Gly Val  Lys Lys Gly 
    1100                 1105                 1110             

Trp Gln  Arg Ala Tyr Ala Val  Val Cys Glu Cys Lys  Leu Phe Leu 
    1115                 1120                 1125             

Tyr Asp  Leu Pro Glu Gly Lys  Ser Thr Gln Pro Gly  Val Ile Ala 
    1130                 1135                 1140             

Ser Gln  Val Leu Asp Leu Arg  Asp Asp Glu Phe Ser  Val Ser Ser 
    1145                 1150                 1155             

Val Leu  Ala Ser Asp Val Ile  His Ala Thr Arg Arg  Asp Ile Pro 
    1160                 1165                 1170             

Cys Ile  Phe Arg Val Thr Ala  Ser Leu Leu Gly Ala  Pro Ser Lys 
    1175                 1180                 1185             

Thr Ser  Ser Leu Leu Ile Leu  Thr Glu Asn Glu Asn  Glu Lys Arg 
    1190                 1195                 1200             

Lys Trp  Val Gly Ile Leu Glu  Gly Leu Gln Ser Ile  Leu His Lys 
    1205                 1210                 1215             

Asn Arg  Leu Arg Asn Gln Val  Val His Val Pro Leu  Glu Ala Tyr 
    1220                 1225                 1230             

Asp Ser  Ser Leu Pro Leu Ile  Lys Ala Ile Leu Thr  Ala Ala Ile 
    1235                 1240                 1245             

Val Asp  Ala Asp Arg Ile Ala  Val Gly Leu Glu Glu  Gly Leu Tyr 
    1250                 1255                 1260             

Val Ile  Glu Val Thr Arg Asp  Val Ile Val Arg Ala  Ala Asp Cys 
    1265                 1270                 1275             

Lys Lys  Val His Gln Ile Glu  Leu Ala Pro Arg Glu  Lys Ile Val 
    1280                 1285                 1290             

Ile Leu  Leu Cys Gly Arg Asn  His His Val His Leu  Tyr Pro Trp 
    1295                 1300                 1305             

Ser Ser  Leu Asp Gly Ala Glu  Gly Ser Phe Asp Ile  Lys Leu Pro 
    1310                 1315                 1320             

Glu Thr  Lys Gly Cys Gln Leu  Met Ala Thr Ala Thr  Leu Lys Arg 
    1325                 1330                 1335             

Asn Ser  Gly Thr Cys Leu Phe  Val Ala Val Lys Arg  Leu Ile Leu 
    1340                 1345                 1350             

Cys Tyr  Glu Ile Gln Arg Thr  Lys Pro Phe His Arg  Lys Phe Asn 
    1355                 1360                 1365             

Glu Ile  Val Ala Pro Gly Ser  Val Gln Cys Leu Ala  Val Leu Arg 
    1370                 1375                 1380             

Asp Arg  Leu Cys Val Gly Tyr  Pro Ser Gly Phe Cys  Leu Leu Ser 
    1385                 1390                 1395             

Ile Gln  Gly Asp Gly Gln Pro  Leu Asn Leu Val Asn  Pro Asn Asp 
    1400                 1405                 1410             

Pro Ser  Leu Ala Phe Leu Ser  Gln Gln Ser Phe Asp  Ala Leu Cys 
    1415                 1420                 1425             

Ala Val  Glu Leu Glu Ser Glu  Glu Tyr Leu Leu Cys  Phe Ser His 
    1430                 1435                 1440             

Met Gly  Leu Tyr Val Asp Pro  Gln Gly Arg Arg Ala  Arg Ala Gln 
    1445                 1450                 1455             

Glu Leu  Met Trp Pro Ala Ala  Pro Val Ala Cys Ser  Cys Ser Pro 
    1460                 1465                 1470             

Thr His  Val Thr Val Tyr Ser  Glu Tyr Gly Val Asp  Val Phe Asp 
    1475                 1480                 1485             

Val Arg  Thr Met Glu Trp Val  Gln Thr Ile Gly Leu  Arg Arg Ile 
    1490                 1495                 1500             

Arg Pro  Leu Asn Ser Glu Gly  Thr Leu Asn Leu Leu  Asn Cys Glu 
    1505                 1510                 1515             

Pro Pro  Arg Leu Ile Tyr Phe  Lys Ser Lys Phe Ser  Gly Ala Val 
    1520                 1525                 1530             

Leu Asn  Val Pro Asp Thr Ser  Asp Asn Ser Lys Lys  Gln Met Leu 
    1535                 1540                 1545             

Arg Thr  Arg Ser Lys Arg Arg  Phe Val Phe Lys Val  Pro Glu Glu 
    1550                 1555                 1560             

Glu Arg  Leu Gln Gln Arg Arg  Glu Met Leu Arg Asp  Pro Glu Leu 
    1565                 1570                 1575             

Arg Ser  Lys Met Ile Ser Asn  Pro Thr Asn Phe Asn  His Val Ala 
    1580                 1585                 1590             

His Met  Gly Pro Gly Asp Gly  Met Gln Val Leu Met  Asp Leu Pro 
    1595                 1600                 1605             

Leu Ser  Ala Val Pro Pro Ser  Gln Glu Glu Arg Pro  Gly Pro Ala 
    1610                 1615                 1620             

Pro Thr  Asn Leu Ala Arg Gln  Pro Pro Ser Arg Asn  Lys Pro Tyr 
    1625                 1630                 1635             

Ile Ser  Trp Pro Ser Ser Gly  Gly Ser Glu Pro Ser  Val Thr Val 
    1640                 1645                 1650             

Pro Leu  Arg Ser Met Ser Asp  Pro Asp Gln Asp Phe  Asp Lys Glu 
    1655                 1660                 1665             

Pro Asp  Ser Asp Ser Thr Lys  His Ser Thr Pro Ser  Asn Ser Ser 
    1670                 1675                 1680             

Asn Pro  Ser Gly Pro Pro Ser  Pro Asn Ser Pro His  Arg Ser Gln 
    1685                 1690                 1695             

Leu Pro  Leu Glu Gly Leu Glu  Gln Pro Ala Cys Asp  Thr 
    1700                 1705                 1710     

<210>  11

<211>  2287

<212>  DNA

<213>  Homo sapiens



<400>  11
ggctgaggca gtggctcctt gcacagcagc tgcacgcgcc gtggctccgg atcttcttcg     60

tctttgcagc gtagcccgag tcggtcagcg ccagaggacc tcagcagcca tgtcgaagcc    120

ccatagtgaa gccgggactg ccttcattca gacccagcag ctgcacgcag ccatggctga    180

cacattcctg gagcacatgt gccgcctgga cattgattca ccacccatca cagcccggaa    240

cactggcatc atctgtacca ttggcccagc ttcccgatca gtggagacgt tgaaggagat    300

gattaagtct ggaatgaatg tggctcgtct gaacttctct catggaactc atgagtacca    360

tgcggagacc atcaagaatg tgcgcacagc cacggaaagc tttgcttctg accccatcct    420

ctaccggccc gttgctgtgg ctctagacac taaaggacct gagatccgaa ctgggctcat    480

caagggcagc ggcactgcag aggtggagct gaagaaggga gccactctca aaatcacgct    540

ggataacgcc tacatggaaa agtgtgacga gaacatcctg tggctggact acaagaacat    600

ctgcaaggtg gtggaagtgg gcagcaagat ctacgtggat gatgggctta tttctctcca    660

ggtgaagcag aaaggtgccg acttcctggt gacggaggtg gaaaatggtg gctccttggg    720

cagcaagaag ggtgtgaacc ttcctggggc tgctgtggac ttgcctgctg tgtcggagaa    780

ggacatccag gatctgaagt ttggggtcga gcaggatgtt gatatggtgt ttgcgtcatt    840

catccgcaag gcatctgatg tccatgaagt taggaaggtc ctgggagaga agggaaagaa    900

catcaagatt atcagcaaaa tcgagaatca tgagggggtt cggaggtttg atgaaatcct    960

ggaggccagt gatgggatca tggtggctcg tggtgatcta ggcattgaga ttcctgcaga   1020

gaaggtcttc cttgctcaga agatgatgat tggacggtgc aaccgagctg ggaagcctgt   1080

catctgtgct actcagatgc tggagagcat gatcaagaag ccccgcccca ctcgggctga   1140

aggcagtgat gtggccaatg cagtcctgga tggagccgac tgcatcatgc tgtctggaga   1200

aacagccaaa ggggactatc ctctggaggc tgtgcgcatg cagaacctga ttgcccgtga   1260

ggcagaggct gccatctacc acttgcaatt atttgaggaa ctccgccgcc tggcgcccat   1320

taccagcgac cccacagaag ccaccgccgt gggtgccgtg gaggcctcct tcaagtgctg   1380

cagtggggcc ataatcgtcc tcaccaagtc tggcaggtct gctcaccagg tggccagata   1440

ccgcccacgt gcccccatca ttgctgtgac ccggaatccc cagacagctc gtcaggccca   1500

cctgtaccgt ggcatcttcc ctgtgctgtg caaggaccca gtccaggagg cctgggctga   1560

ggacgtggac ctccgggtga actttgccat gaatgttggc aaggcccgag gcttcttcaa   1620

gaagggagat gtggtcattg tgctgaccgg atggcgccct ggctccggct tcaccaacac   1680

catgcgtgtt gttcctgtgc cgtgatggac cccagagccc ctcctccagc ccctgtccca   1740

cccccttccc ccagcccatc cattaggcca gcaacgcttg tagaactcac tctgggctgt   1800

aacgtggcac tggtaggttg ggacaccagg gaagaagatc aacgcctcac tgaaacatgg   1860

ctgtgtttgc agcctgctct agtgggacag cccagagcct ggctgcccca tcatgtggcc   1920

ccacccaatc aagggaagaa ggaggaatgc tggactggag gcccctggag ccagatggca   1980

agagggtgac agcttccttt cctgtgtgta ctctgtccag ttcctttaga aaaaatggat   2040

gcccagagga ctcccaaccc tggcttgggg tcaagaaaca gccagcaaga gttaggggcc   2100

ttagggcact gggctgttgt tccattgaag ccgactctgg ccctggccct tacttgcttc   2160

tctagctctc taggcctctc cagtttgcac ctgtccccac cctccactca gctgtcctgc   2220

agcaaacact ccaccctcca ccttccattt tcccccacta ctgcagcacc tccaggcctg   2280

ttgccgc                                                             2287


<210>  12

<211>  531

<212>  PRT

<213>  Homo sapiens



<400>  12

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      

Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          

Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              

Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  

Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  

His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      

Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         

Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             

Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 

Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 

Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     

Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         

Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             

Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 

Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 

Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     

Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         

Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             

Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 

Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 

Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     

Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         

Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             

Asp Tyr Pro Leu Glu Ala Val Arg Met Gln Asn Leu Ile Ala Arg Glu 
    370                 375                 380                 

Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 
385                 390                 395                 400 

Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
                405                 410                 415     

Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 
            420                 425                 430         

Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             

Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 

Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 

Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     

Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         

Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             

Pro Val Pro 
    530     

<210>  13

<211>  4364

<212>  DNA

<213>  Homo sapiens



<400>  13
cattagatct ttacatgaaa gtaaaattta taagatttct agaaagtcaa aagatgataa     60

ctatttctta ggatactaaa agcactcaca ttatagaaaa aaaatcagtt aactatactc    120

cacaaacatt aaaggctccc tataaaaaaa catttttaat aggcaagcca cagaaagggc    180

aaatattaat agtttgcaat acatatgtat gaaaaggaat tgaatctaga atatttaaca    240

aagctttaca actcaaaaaa tacaaagaaa atatttttct tccaattggc aaattactta    300

aacagaacct tcacaaaaga agataagaat gtttaataaa catttgaagc cataataatg    360

acatcattag ccatgatgga aatgcaaatt taagtaccac ttcacatcca caagaaaaag    420

ataaaaataa aaggactgag ctcaccaaac attggtgagg atgtggtaat actgaaattc    480

ttgtaccgtg ctcctgaggg tataacatat tacaggattt ttttgaaaac tagtggttcc    540

ttataaactt aatgccctgg caacctcaca cctatttact taagaatgaa agggccccgc    600

cctcctccct cctcgctcgc gggccgggcc cggcatggtg cggcgtcgcc gccgatggcg    660

ctgaggcgga gcatggggcg gccggggctc ccgccgctgc cgctgccgcc gccaccgcgg    720

ctcgggctgc tgctggcgga gtccgccgcc gcaggtctga agctcatggg agccccggtg    780

aagctgacag tgtctcaggg gcagccggtg aagctcaact gcagtgtgga ggggatggag    840

gagcctgaca tccagtgggt gaaggatggg gctgtggtcc agaacttgga ccagttgtac    900

atcccagtca gcgagcagca ctggatcggc ttcctcagcc tgaagtcagt ggagcgctct    960

gacgccggcc ggtactggtg ccaggtggag gatgggggtg aaaccgagat ctcccagcca   1020

gtgtggctca cggtagaagg tgtgccattt ttcacagtgg agccaaaaga tctggcagtg   1080

ccacccaatg cccctttcca actgtcttgt gaggctgtgg gtccccctga acctgttacc   1140

attgtctggt ggagaggaac tacgaagatc gggggacccg ctccctctcc atctgtttta   1200

aatgtaacag gggtgaccca gagcaccatg ttttcctgtg aagctcacaa cctaaaaggc   1260

ctggcctctt ctcgcacagc cactgttcac cttcaagcac tgcctgcagc ccccttcaac   1320

atcaccgtga caaagctttc cagcagcaac gctagtgtgg cctggatgcc aggtgctgat   1380

ggccgagctc tgctacagtc ctgtacagtt caggtgacac aggccccagg aggctgggaa   1440

gtcctggctg ttgtggtccc tgtgcccccc tttacctgcc tgctccggga cctggtgcct   1500

gccaccaact acagcctcag ggtgcgctgt gccaatgcct tggggccctc tccctatgct   1560

gactgggtgc cctttcagac caagggtcta gccccagcca gcgctcccca aaacctccat   1620

gccatccgca cagattcagg cctcatcttg gagtgggaag aagtgatccc cgaggcccct   1680

ttggaaggcc ccctgggacc ctacaaactg tcctgggttc aagacaatgg aacccaggat   1740

gagctgacag tggaggggac cagggccaat ttgacaggct gggatcccca aaaggacctg   1800

atcgtacgtg tgtgcgtctc caatgcagtt ggctgtggac cctggagtca gccactggtg   1860

gtctcttctc atgaccgtgc aggccagcag ggccctcctc acagccgcac atcctgggta   1920

cctgtggtcc ttggtgtgct aacggccctg gtgacggctg ctgccctggc cctcatcctg   1980

cttcgaaaga gacggaaaga gacgcggttt gggcaagcct ttgacagtgt catggcccgg   2040

ggagagccag ccgttcactt ccgggcagcc cggtccttca atcgagaaag gcccgagcgc   2100

atcgaggcca cattggacag cttgggcatc agcgatgaac taaaggaaaa actggaggat   2160

gtgctcatcc cagagcagca gttcaccctg ggccggatgt tgggcaaagg agagtttggt   2220

tcagtgcggg aggcccagct gaagcaagag gatggctcct ttgtgaaagt ggctgtgaag   2280

atgctgaaag ctgacatcat tgcctcaagc gacattgaag agttcctcag ggaagcagct   2340

tgcatgaagg agtttgacca tccacacgtg gccaaacttg ttggggtaag cctccggagc   2400

agggctaaag gccgtctccc catccccatg gtcatcttgc ccttcatgaa gcatggggac   2460

ctgcatgcct tcctgctcgc ctcccggatt ggggagaacc cctttaacct acccctccag   2520

accctgatcc ggttcatggt ggacattgcc tgcggcatgg agtacctgag ctctcggaac   2580

ttcatccacc gagacctggc tgctcggaat tgcatgctgg cagaggacat gacagtgtgt   2640

gtggctgact tcggactctc ccggaagatc tacagtgggg actactatcg tcaaggctgt   2700

gcctccaaac tgcctgtcaa gtggctggcc ctggagagcc tggccgacaa cctgtatact   2760

gtgcagagtg acgtgtgggc gttcggggtg accatgtggg agatcatgac acgtgggcag   2820

acgccatatg ctggcatcga aaacgctgag atttacaact acctcattgg cgggaaccgc   2880

ctgaaacagc ctccggagtg tatggaggac gtgtatgatc tcatgtacca gtgctggagt   2940

gctgacccca agcagcgccc gagctttact tgtctgcgaa tggaactgga gaacatcttg   3000

ggccagctgt ctgtgctatc tgccagccag gaccccttat acatcaacat cgagagagct   3060

gaggagccca ctgtgggagg cagcctggag ctacctggca gggatcagcc ctacagtggg   3120

gctggggatg gcagtggcat gggggcagtg ggtggcactc ccagtgactg tcggtacata   3180

ctcacccccg gagggctggc tgagcagcca gggcaggcag agcaccagcc agagagtccc   3240

ctcaatgaga cacagaggct tttgctgctg cagcaagggc tactgccaca cagtagctgt   3300

tagcccacag gcagagggca tcggggccat ttggccggct ctggtggcca ctgagctggc   3360

tgactaagcc ccgtctgacc ccagcccaga cagcaaggtg tggaggctcc tgtggtagtc   3420

ctcccaagct gtgctgggaa gcccggactg accaaatcac ccaatcccag ttcttcctgc   3480

aaccactctg tggccagcct ggcatcagtt taggccttgg cttgatggaa gtgggccagt   3540

cctggttgtc tgaacccagg cagctggcag gagtggggtg gttatgtttc catggttacc   3600

atgggtgtgg atggcagtgt ggggagggca ggtccagctc tgtgggccct accctcctgc   3660

tgagctgccc ctgctgctta agtgcatgca ttgagctgcc tccagcctgg tggcccagct   3720

attaccacac ttggggttta aatatccagg tgtgcccctc caagtcagaa agagatgtcc   3780

ttgtaatatt cccttttagg tgagggttgg taaggggttg gtatctcagg tctgaatctt   3840

caccatcttt ctgattccgc accctgccta cgccaggaga agttgagggg agcatgcttc   3900

cctgcagctg accgggtcac acaaaggcat gctggagtac ccagcctatc aggtgcccct   3960

cttccaaagg cagcgtgccg agccagcaag aggaaggggt gctgtgaggc ttgcccagga   4020

gcaagtgagg ccggagagga gttcaggaac ccttctccat acccacaatc tgagcacgct   4080

accaaatctc aaaatatcct aagactaaca aaggcagctg tgtctgagcc caacccttct   4140

aaacggtgac ctttagtgcc aacttcccct ctaactggac agcctcttct gtcccaagtc   4200

tccagagaga aatcaggcct gatgaggggg aattcctgga acctggaccc cagccttggt   4260

gggggagcct ctggaatgca tggggcgggt cctagctgtt agggacattt ccaagctgtt   4320

agttgctgtt taaaatagaa ataaaattga agactaaaga ccta                    4364


<210>  14

<211>  882

<212>  PRT

<213>  Homo sapiens



<400>  14

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 
1               5                   10                  15      

Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Glu Ser Ala Ala 
            20                  25                  30          

Ala Gly Leu Lys Leu Met Gly Ala Pro Val Lys Leu Thr Val Ser Gln 
        35                  40                  45              

Gly Gln Pro Val Lys Leu Asn Cys Ser Val Glu Gly Met Glu Glu Pro 
    50                  55                  60                  

Asp Ile Gln Trp Val Lys Asp Gly Ala Val Val Gln Asn Leu Asp Gln 
65                  70                  75                  80  

Leu Tyr Ile Pro Val Ser Glu Gln His Trp Ile Gly Phe Leu Ser Leu 
                85                  90                  95      

Lys Ser Val Glu Arg Ser Asp Ala Gly Arg Tyr Trp Cys Gln Val Glu 
            100                 105                 110         

Asp Gly Gly Glu Thr Glu Ile Ser Gln Pro Val Trp Leu Thr Val Glu 
        115                 120                 125             

Gly Val Pro Phe Phe Thr Val Glu Pro Lys Asp Leu Ala Val Pro Pro 
    130                 135                 140                 

Asn Ala Pro Phe Gln Leu Ser Cys Glu Ala Val Gly Pro Pro Glu Pro 
145                 150                 155                 160 

Val Thr Ile Val Trp Trp Arg Gly Thr Thr Lys Ile Gly Gly Pro Ala 
                165                 170                 175     

Pro Ser Pro Ser Val Leu Asn Val Thr Gly Val Thr Gln Ser Thr Met 
            180                 185                 190         

Phe Ser Cys Glu Ala His Asn Leu Lys Gly Leu Ala Ser Ser Arg Thr 
        195                 200                 205             

Ala Thr Val His Leu Gln Ala Leu Pro Ala Ala Pro Phe Asn Ile Thr 
    210                 215                 220                 

Val Thr Lys Leu Ser Ser Ser Asn Ala Ser Val Ala Trp Met Pro Gly 
225                 230                 235                 240 

Ala Asp Gly Arg Ala Leu Leu Gln Ser Cys Thr Val Gln Val Thr Gln 
                245                 250                 255     

Ala Pro Gly Gly Trp Glu Val Leu Ala Val Val Val Pro Val Pro Pro 
            260                 265                 270         

Phe Thr Cys Leu Leu Arg Asp Leu Val Pro Ala Thr Asn Tyr Ser Leu 
        275                 280                 285             

Arg Val Arg Cys Ala Asn Ala Leu Gly Pro Ser Pro Tyr Ala Asp Trp 
    290                 295                 300                 

Val Pro Phe Gln Thr Lys Gly Leu Ala Pro Ala Ser Ala Pro Gln Asn 
305                 310                 315                 320 

Leu His Ala Ile Arg Thr Asp Ser Gly Leu Ile Leu Glu Trp Glu Glu 
                325                 330                 335     

Val Ile Pro Glu Ala Pro Leu Glu Gly Pro Leu Gly Pro Tyr Lys Leu 
            340                 345                 350         

Ser Trp Val Gln Asp Asn Gly Thr Gln Asp Glu Leu Thr Val Glu Gly 
        355                 360                 365             

Thr Arg Ala Asn Leu Thr Gly Trp Asp Pro Gln Lys Asp Leu Ile Val 
    370                 375                 380                 

Arg Val Cys Val Ser Asn Ala Val Gly Cys Gly Pro Trp Ser Gln Pro 
385                 390                 395                 400 

Leu Val Val Ser Ser His Asp Arg Ala Gly Gln Gln Gly Pro Pro His 
                405                 410                 415     

Ser Arg Thr Ser Trp Val Pro Val Val Leu Gly Val Leu Thr Ala Leu 
            420                 425                 430         

Val Thr Ala Ala Ala Leu Ala Leu Ile Leu Leu Arg Lys Arg Arg Lys 
        435                 440                 445             

Glu Thr Arg Phe Gly Gln Ala Phe Asp Ser Val Met Ala Arg Gly Glu 
    450                 455                 460                 

Pro Ala Val His Phe Arg Ala Ala Arg Ser Phe Asn Arg Glu Arg Pro 
465                 470                 475                 480 

Glu Arg Ile Glu Ala Thr Leu Asp Ser Leu Gly Ile Ser Asp Glu Leu 
                485                 490                 495     

Lys Glu Lys Leu Glu Asp Val Leu Ile Pro Glu Gln Gln Phe Thr Leu 
            500                 505                 510         

Gly Arg Met Leu Gly Lys Gly Glu Phe Gly Ser Val Arg Glu Ala Gln 
        515                 520                 525             

Leu Lys Gln Glu Asp Gly Ser Phe Val Lys Val Ala Val Lys Met Leu 
    530                 535                 540                 

Lys Ala Asp Ile Ile Ala Ser Ser Asp Ile Glu Glu Phe Leu Arg Glu 
545                 550                 555                 560 

Ala Ala Cys Met Lys Glu Phe Asp His Pro His Val Ala Lys Leu Val 
                565                 570                 575     

Gly Val Ser Leu Arg Ser Arg Ala Lys Gly Arg Leu Pro Ile Pro Met 
            580                 585                 590         

Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ala Phe Leu Leu 
        595                 600                 605             

Ala Ser Arg Ile Gly Glu Asn Pro Phe Asn Leu Pro Leu Gln Thr Leu 
    610                 615                 620                 

Ile Arg Phe Met Val Asp Ile Ala Cys Gly Met Glu Tyr Leu Ser Ser 
625                 630                 635                 640 

Arg Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Ala 
                645                 650                 655     

Glu Asp Met Thr Val Cys Val Ala Asp Phe Gly Leu Ser Arg Lys Ile 
            660                 665                 670         

Tyr Ser Gly Asp Tyr Tyr Arg Gln Gly Cys Ala Ser Lys Leu Pro Val 
        675                 680                 685             

Lys Trp Leu Ala Leu Glu Ser Leu Ala Asp Asn Leu Tyr Thr Val Gln 
    690                 695                 700                 

Ser Asp Val Trp Ala Phe Gly Val Thr Met Trp Glu Ile Met Thr Arg 
705                 710                 715                 720 

Gly Gln Thr Pro Tyr Ala Gly Ile Glu Asn Ala Glu Ile Tyr Asn Tyr 
                725                 730                 735     

Leu Ile Gly Gly Asn Arg Leu Lys Gln Pro Pro Glu Cys Met Glu Asp 
            740                 745                 750         

Val Tyr Asp Leu Met Tyr Gln Cys Trp Ser Ala Asp Pro Lys Gln Arg 
        755                 760                 765             

Pro Ser Phe Thr Cys Leu Arg Met Glu Leu Glu Asn Ile Leu Gly Gln 
    770                 775                 780                 

Leu Ser Val Leu Ser Ala Ser Gln Asp Pro Leu Tyr Ile Asn Ile Glu 
785                 790                 795                 800 

Arg Ala Glu Glu Pro Thr Val Gly Gly Ser Leu Glu Leu Pro Gly Arg 
                805                 810                 815     

Asp Gln Pro Tyr Ser Gly Ala Gly Asp Gly Ser Gly Met Gly Ala Val 
            820                 825                 830         

Gly Gly Thr Pro Ser Asp Cys Arg Tyr Ile Leu Thr Pro Gly Gly Leu 
        835                 840                 845             

Ala Glu Gln Pro Gly Gln Ala Glu His Gln Pro Glu Ser Pro Leu Asn 
    850                 855                 860                 

Glu Thr Gln Arg Leu Leu Leu Leu Gln Gln Gly Leu Leu Pro His Ser 
865                 870                 875                 880 

Ser Cys 
        

<210>  15

<211>  1457

<212>  DNA

<213>  Homo sapiens



<400>  15
ggccgcttcg ggtttccgga ggggccggag ggcgggcgag ggcgtcacgt gcgcgccgcc     60

cgcgggccgg ttggtccccg ggcgggggag gggccgtgcg cagcctgggt cggggtcggg    120

ccggggtcgg cacctgggac atccctgagg gaagggccgg gagcgggagc gccccagcgg    180

ccggcgggcg ggcgggcgag cggacgagcg gcgcggagcc ggcccgaggc gcgcgccgag    240

ggagccccgt ccccggtcgt gggggcaccg cccgcaggct ctgcggggtg ggcagctccc    300

gggcctgcca tgagctctcc gccgcccgcc cgcagtggct tttaccgcca ggaggtgacc    360

aagacggcct gggaggtgcg cgccgtgtac cgggacctgc agcccgtggg ctcgggcgcc    420

tacggcgcgg tgtgctcggc cgtggacggc cgcaccggcg ctaaggtggc catcaagaag    480

ctgtatcggc ccttccagtc cgagctgttc gccaagcgcg cctaccgcga gctgcgcctg    540

ctcaagcaca tgcgccacga gaacgtgatc gggctgctgg acgtattcac tcctgatgag    600

accctggatg acttcacgga cttttacctg gtgatgccgt tcatgggcac cgacctgggc    660

aagctcatga aacatgagaa gctaggcgag gaccggatcc agttcctcgt gtaccagatg    720

ctgaaggggc tgaggtatat ccacgctgcc ggcatcatcc acagagacct gaagcccggc    780

aacctggctg tgaacgaaga ctgtgagctg aagatcctgg acttcggcct ggccaggcag    840

gcagacagtg agatgactgg gtacgtggtg acccggtggt accgggctcc cgaggtcatc    900

ttgaattgga tgcgctacac gcagacggtg gacatctggt ccgtgggctg catcatggcg    960

gagatgatca caggcaagac gctgttcaag ggcagcgacc acctggacca gctgaaggag   1020

atcatgaagg tgacggggac gcctccggct gagtttgtgc agcggctgca gagcgatgag   1080

gccaagaaca acatgaaggg cctccccgaa ttggagaaga aggattttgc ctctatcctg   1140

accaatgcaa gccctctggc tgtgaacctc ctggagaaga tgctggtgct ggacgcggag   1200

cagcgggtga cggcaggcga ggcgctggcc catccctact tcgagtccct gcacgacacg   1260

gaagatgagc cccaggtcca gaagtatgat gactcctttg acgacgttga ccgcacactg   1320

gatgaatgga agcgtgttac ttacaaagag gtgctcagct tcaagcctcc ccggcagctg   1380

ggggccaggg tctccaagga gacgcctctg tgaagatctc tgggctccgg ggtggcagtg   1440

aggaccacct tcacctt                                                  1457


<210>  16

<211>  367

<212>  PRT

<213>  Homo sapiens



<400>  16

Met Ser Ser Pro Pro Pro Ala Arg Ser Gly Phe Tyr Arg Gln Glu Val 
1               5                   10                  15      

Thr Lys Thr Ala Trp Glu Val Arg Ala Val Tyr Arg Asp Leu Gln Pro 
            20                  25                  30          

Val Gly Ser Gly Ala Tyr Gly Ala Val Cys Ser Ala Val Asp Gly Arg 
        35                  40                  45              

Thr Gly Ala Lys Val Ala Ile Lys Lys Leu Tyr Arg Pro Phe Gln Ser 
    50                  55                  60                  

Glu Leu Phe Ala Lys Arg Ala Tyr Arg Glu Leu Arg Leu Leu Lys His 
65                  70                  75                  80  

Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 
                85                  90                  95      

Glu Thr Leu Asp Asp Phe Thr Asp Phe Tyr Leu Val Met Pro Phe Met 
            100                 105                 110         

Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 
        115                 120                 125             

Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Tyr Ile 
    130                 135                 140                 

His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn Leu Ala 
145                 150                 155                 160 

Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 
                165                 170                 175     

Gln Ala Asp Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg 
            180                 185                 190         

Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr Val Asp 
        195                 200                 205             

Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly Lys Thr 
    210                 215                 220                 

Leu Phe Lys Gly Ser Asp His Leu Asp Gln Leu Lys Glu Ile Met Lys 
225                 230                 235                 240 

Val Thr Gly Thr Pro Pro Ala Glu Phe Val Gln Arg Leu Gln Ser Asp 
                245                 250                 255     

Glu Ala Lys Asn Asn Met Lys Gly Leu Pro Glu Leu Glu Lys Lys Asp 
            260                 265                 270         

Phe Ala Ser Ile Leu Thr Asn Ala Ser Pro Leu Ala Val Asn Leu Leu 
        275                 280                 285             

Glu Lys Met Leu Val Leu Asp Ala Glu Gln Arg Val Thr Ala Gly Glu 
    290                 295                 300                 

Ala Leu Ala His Pro Tyr Phe Glu Ser Leu His Asp Thr Glu Asp Glu 
305                 310                 315                 320 

Pro Gln Val Gln Lys Tyr Asp Asp Ser Phe Asp Asp Val Asp Arg Thr 
                325                 330                 335     

Leu Asp Glu Trp Lys Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys 
            340                 345                 350         

Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
        355                 360                 365         

<210>  17

<211>  5243

<212>  DNA

<213>  Homo sapiens



<400>  17
cttttcttgc aggacatgtt ctctggatgt cagctgagtc attaaagtaa ctctgcatgt     60

cagtagacag accttggtag aaccacaagg ctcccagaga cacccatctc tcctcatttt    120

tttggtgtgt gtgtcttcac cgaacattca aaactgtttc tccaaagcgt tttgcaaaaa    180

ctcagactgt tttccaaagc agaagcactg gagtccccag cagaagcgat gggcagtgtg    240

cgaaccaacc gctacagcat cgtctcttca gaagaagacg gtatgaagtt ggccaccatg    300

gcagttgcaa atggctttgg gaacgggaag agtaaagtcc acacccgaca acagtgcagg    360

agccgctttg tgaagaaaga tggccactgt aatgttcagt tcatcaatgt gggtgagaag    420

gggcaacggt acctcgcaga catcttcacc acgtgtgtgg acattcgctg gcggtggatg    480

ctggttatct tctgcctggc tttcgtcctg tcatggctgt tttttggctg tgtgttttgg    540

ttgatagctc tgctccatgg ggacctggat gcatccaaag agggcaaagc ttgtgtgtcc    600

gaggtcaaca gcttcacggc tgccttcctc ttctccattg agacccagac aaccataggc    660

tatggtttca gatgtgtcac ggatgaatgc ccaattgctg ttttcatggt ggtgttccag    720

tcaatcgtgg gctgcatcat cgatgctttc atcattggcg cagtcatggc caagatggca    780

aagccaaaga agagaaacga gactcttgtc ttcagtcaca atgccgtgat tgccatgaga    840

gacggcaagc tgtgtttgat gtggcgagtg ggcaatcttc ggaaaagcca cttggtggaa    900

gctcatgttc gagcacagct cctcaaatcc agaattactt ctgaagggga gtatatccct    960

ctggatcaaa tagacatcaa tgttgggttt gacagtggaa tcgatcgtat atttctggtg   1020

tccccaatca ctatagtcca tgaaatagat gaagacagtc ctttatatga tttgagtaaa   1080

caggacattg acaacgcaga ctttgaaatc gtggtcatac tggaaggcat ggtggaagcc   1140

actgccatga cgacacagtg ccgtagctct tatctagcaa atgaaatcct gtggggccac   1200

cgctatgagc ctgtgctctt tgaagagaag cactactaca aagtggacta ttccaggttc   1260

cacaaaactt acgaagtccc caacactccc ctttgtagtg ccagagactt agcagaaaag   1320

aaatatatcc tctcaaatgc aaattcattt tgctatgaaa atgaagttgc cctcacaagc   1380

aaagaggaag acgacagtga aaatggagtt ccagaaagca ctagtacgga cacgccccct   1440

gacatagacc ttcacaacca ggcaagtgta cctctagagc ccaggccctt acggcgagag   1500

tcggagatat gactgactga ttccttctct ggaatagtta ctttacaaca cggtctgttg   1560

gtcagaggcc caaaacagtt atacagatga cggtactggt caagatgggt caagcaagcg   1620

gccacaaggg actgaggcaa gcacaatggt ttcaaagaaa gactgtaagc tccatgatta   1680

gcataaagca ctaaccatgt ctccatgtga cccgatggca catagatgtt gtagaataag   1740

ttatgggttt ttatgttttg ttttgtgttt ttccaaaact tgaacttgca ggcaagcctt   1800

ggttgggtat ttgatttatc cagaatgctt ctctttaggg aacaaggatg tttttaatgg   1860

cataacaaag gcaagactct gccttaattt ttgaaaagct gctaactaca tgaacacaaa   1920

tgtgtatttt tgttgcagtg tagttttcct tttgtgtaat tttaaagtca gtgttgaatt   1980

ttattgaaag ctcatgatgc gcttcaaagt ggcaagtatt tggctattaa ctgccaaaac   2040

aagagcctga ttttttgagg ccagtaattc gtttgctaga attgattttt tttctctctc   2100

tctttgttac ataagggcat tatgtaacac tagccgaatg gtagcctctg ggttgttgtt   2160

tttttctttt cctccatgat gttaatgggt tatctcaaat tttaagttaa actacctaaa   2220

ataaatacca aagataatgc atatttttgc acagtggagc ttacacttaa aagaaaacaa   2280

agccccatgg gctgccttga aatcaagaga caataacttt gaacctcagc aagaccttga   2340

accgccggtt cattttgcac cttattcaga aaatagagca tcatactcac cgagtctagt   2400

cagtgtagtg cttttaaaaa ttttgtcctt tcatgtaact tttttatttt aagaggaaga   2460

agaagaaagg ggcacacaca cacaataccg acgtctatcc tttcctgcta ggcagtgctg   2520

gccaggctca tgtgtagtgt gcgagatggt gatgtactct tatatttttc tgggcttttc   2580

cttttgcaca ttccaaaatt catttcataa gacaagatct tcataggacc tccttggcat   2640

cctggcattc tcaaaactga gccatccagc atgaaagata aatgggttta aacccttgct   2700

gctgaattta ttgcctggac tgtcaggaca tcaccagccc accttcacct tagggaagat   2760

gccacacctg gcctccacac ttgctcttct gatcagtctg tctggattga gtcctacagt   2820

gtcagatagg gcggcaaatg ccaaagcagg gaaacaggga ggtgtggaca agccagtttg   2880

atgcagcact tcagatcaag tgcttaggaa ggagaggaaa cttgcctttt ttatggcaga   2940

ggatagtaat gaaaatgtct cagtatttta gggtcaatga gagccataaa aatataacat   3000

aatcacaagt aaaggagata atggtctaaa acagctattt cccttttctg tgtgcatact   3060

tatgactgaa tgtgagctaa gcattttctc ctgtggagcc ctagagcagg ttactaagga   3120

aggacacatt gttttccaga agcctcccct gcctggctga ctgccttgct agaaacataa   3180

tttttttttt ctcactgaag ctcaataatg gaactctttt tttttttttt tttaatttaa   3240

agttccctat ttgtgaattc tgggattact gacttttctt tttaattgga gtctcaaaat   3300

caactctctt atggtattat atctctgtat gccattaaaa aacagcttgt tctagaatca   3360

tgtattttgt aaactgatgt ttgtgatggt ctctggttct tgaacagcca tatctgaatg   3420

ccgtgcctgc aaaactatga caatttttgc tgttttcagc cttcagattt gatggcttgg   3480

gaaactgagg tgttattttc aatgaaacaa agaaagagat gttaagcaag tggttgtttt   3540

agatccaaat gtaaaggcag gtttgggaag gtgtttaaag agttggagga attggggatt   3600

gagttgtaaa gaaaacttac agaagaggca acaatttggt tcttgacagt gagaggatat   3660

tgagggcttc agctgctgct attatgatgt tttgcaaagg aaaataatca aaccaaagag   3720

tattcagtga tatgtaaatt aaatgaagat acagtggaga atgggggtga ccacaaaaga   3780

ggctccccct aaacacacag tgctgccact taaaaagact tgagaaattt gaaagggggt   3840

gggtatgggg ggggcaagaa agagggaggg aaatctttca acttatttct gaaaaagaga   3900

aaaaaatata aaatttctgg tgcacaggtt tgttttttca agaaaatttt gcagaagcta   3960

tgtttttaaa gtgtacattt tataaagttt atcagatatt ttcatattta aagccaaatg   4020

taaatagagg tctgtaaaga aaaataattg ccatagaaag tataatttca gtgcagtaat   4080

ttctgagagc tagtacctat atgctaccgg ttagcatggt tttagcaaat atataccagc   4140

cttataaggt tcgtattgct atgttcttct gttatttatt tcagcatgga ctgttcattt   4200

gaaacctttt tctagttatt agcgttttaa cagttacaag ctttaaatgg caattttttt   4260

tttttttttt tttttttttt tttttttgtc aagagccaag acacaggtaa tgcacgacat   4320

tgattgctgc attttacctt caaaatattt gtccttattg actgggtctc cttaattaat   4380

gtacacatgt cattagaatg cagacggagg ggactcacca tgaatatctg gggttgattc   4440

ccagatgtgt gttgcttctc tattgcaagc agattccctg ttggatttac ttcggattta   4500

ttccctttta aagaattttt gcccatatct ggaagggcac tatatttttg ggaggagcca   4560

tagattcctg gttatcctat ttttaaacaa aatgtagaca aagtgaactc tattttgatt   4620

attgagaaag gagtagtttt ctatccctct aagagtatac ttgaatcaga cattttaagg   4680

atgtcactat ggcactgttg tcatttccaa attcctagaa aagtttgttt tactttgttt   4740

ttattctgtt aatgcattct ttcttctctt tacttccttt cttaccagta cactcctatc   4800

tcaactctgt ttatttgatg agttctgtcc cgtaaatcat atttccctta caattaataa   4860

atgtcacttc atattttata ataaaccact cagtaaaagc aaaagcttgt cctgagaagt   4920

agagtgagtt ctttttcact ctgtgtctaa taatgttaag gtgggaaaaa aaaaagtgtg   4980

gcatagctac ctgcccatcc ccaaccctca gcaaagtaga atctcttttc tggtaatttt   5040

gggtttccgc tctgggctct ggcaagttga acaatcctag ccattgacaa tcgtgatagt   5100

tattattttc ccatttgctg tctttttgta tctaaagtct tcctattgta ctgcacaaac   5160

catggattgt acatattttt atatattatg tcttatttta ttatttctaa ataaaaaaat   5220

taaaaattga aaacaaattc ttg                                           5243


<210>  18

<211>  427

<212>  PRT

<213>  Homo sapiens



<400>  18

Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu 
1               5                   10                  15      

Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn 
            20                  25                  30          

Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val 
        35                  40                  45              

Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys 
    50                  55                  60                  

Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg 
65                  70                  75                  80  

Trp Arg Trp Met Leu Val Ile Phe Cys Leu Ala Phe Val Leu Ser Trp 
                85                  90                  95      

Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp 
            100                 105                 110         

Leu Asp Ala Ser Lys Glu Gly Lys Ala Cys Val Ser Glu Val Asn Ser 
        115                 120                 125             

Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly 
    130                 135                 140                 

Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met 
145                 150                 155                 160 

Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile 
                165                 170                 175     

Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr 
            180                 185                 190         

Leu Val Phe Ser His Asn Ala Val Ile Ala Met Arg Asp Gly Lys Leu 
        195                 200                 205             

Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu 
    210                 215                 220                 

Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly 
225                 230                 235                 240 

Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Gly Phe Asp Ser 
                245                 250                 255     

Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu 
            260                 265                 270         

Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Ile Asp 
        275                 280                 285             

Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala 
    290                 295                 300                 

Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile 
305                 310                 315                 320 

Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys His Tyr 
                325                 330                 335     

Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn 
            340                 345                 350         

Thr Pro Leu Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu 
        355                 360                 365             

Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser 
    370                 375                 380                 

Lys Glu Glu Asp Asp Ser Glu Asn Gly Val Pro Glu Ser Thr Ser Thr 
385                 390                 395                 400 

Asp Thr Pro Pro Asp Ile Asp Leu His Asn Gln Ala Ser Val Pro Leu 
                405                 410                 415     

Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile 
            420                 425         

<210>  19

<211>  1050

<212>  DNA

<213>  Homo sapiens



<400>  19
tttatatttt ttcagtgtcc atatttcaaa aatttattta tctcaaactg tgcataatgg     60

agtaaaaact taagttgaaa atgtacctgt tataaggatg atattagttc aaatatatac    120

atggattctc ggcagactga ttcaaataat acagagccga atcttttaaa atacaactac    180

ggaaaataaa ggggggaaaa ccttaaaata tcacaataaa tttacagaaa tattacaaac    240

cataagaaaa tatttcaaac acagtaattt catggttttt tttatctgaa caaaatggaa    300

agttgggatc gaacaaaagc tattataaat taccaacggt gtcaacctgc atggccattt    360

ttgcttttaa cagtaagtta taaaatttag tacagtctaa aacttttgcc ctttttaaac    420

aagaccacag agatggttcg ccagtactta ttctaatttt ttccttttgt acaattttta    480

aacaattaaa atgtccaaat ttgaataatt ttcttctttt cacgtttgca actgtcctaa    540

atttcagctg cagaatcaaa attcagcaag aagcctctcc ttgaaaaata ttggcaaatt    600

ctcagcttat aaacaatgga cattttgatt gccatgttta tctcgataaa tactgtacaa    660

aagttgcttg caaatattaa aacatttttt tcgtcgcttg gagactagct ctaaatatta    720

ttggtaaaga cttttgcaaa cttcctgcaa agctcctacc gtaccactag aacttttaaa    780

aagtttttcg tagctttctt tcctccagat ctatacaagg tccattcccc cgccctcccc    840

accctcccca ggttttctct gtacaaaaat agtcccccaa aaagaagtcc aggatctctc    900

tcataaaagt tttcttgtcg gcatcgcggt ttttgcgtga gtgtggatgg gattggtgtt    960

ctcttttgca gctgtcattt gctgtgggtg atgggatttt tttttttcct ttttcttttt   1020

gagcgtaccg ggttttctcc atgctgtttc                                    1050


<210>  20

<211>  88

<212>  PRT

<213>  Homo sapiens



<400>  20

Met Glu Lys Thr Arg Tyr Ala Gln Lys Glu Lys Gly Lys Lys Lys Ile 
1               5                   10                  15      

Pro Ser Pro Thr Ala Asn Asp Ser Cys Lys Arg Glu His Gln Ser His 
            20                  25                  30          

Pro His Ser Arg Lys Asn Arg Asp Ala Asp Lys Lys Thr Phe Met Arg 
        35                  40                  45              

Glu Ile Leu Asp Phe Phe Leu Gly Asp Tyr Phe Cys Thr Glu Lys Thr 
    50                  55                  60                  

Trp Gly Gly Trp Gly Gly Arg Gly Asn Gly Pro Cys Ile Asp Leu Glu 
65                  70                  75                  80  

Glu Arg Lys Leu Arg Lys Thr Phe 
                85              

<210>  21

<211>  881

<212>  DNA

<213>  Homo sapiens



<400>  21
tttttttttt ttgtcaagag ccaagacaca ggtaatgcac gacattgatt gctgcatttt     60

accttcaaaa tatttgtcct tattgactgg gtctccttaa ttaatgtaca catgtcatta    120

gaatgcagac ggaggggact caccatgaat attctgggtt gattcccaga tgtgtgttgc    180

ttctctattg caagcagatt ccctgttgga tttacttcgg atttattccc ttttaaagaa    240

tttttgccca tatctggaag ggcactatat ttttgggagg agccatagat tcctggttat    300

cctattttta aacaaaatgt agacaaagtg aactctattt tgattattga gaaaggagta    360

gttttctatc cctctaagag tatacttgaa tcagacattt taaggatgtc actatggcac    420

tgttgtcatt tccaaattcc tagaaaagtt tgttttactt tgtttttatt ctgttaatgc    480

attctttctt ctctttactt cctttcttac cagtacactc ctatctcaac tctgtttatt    540

tgatgagttc tgtcccgtaa atcatatttc ccttacaatt aataaatgtc acttcatatt    600

ttataataaa ccactcagta aaagcaaaag cttgtcctga gaagtactct gtgtctaata    660

atgttaaggg catagctacc tgcccatccc caaccctcag caaagtagaa tctcttttct    720

ggtaattttg ggtttccgct ctgggctctg gcaagttgaa caatcctagc cattgacaat    780

cgtgatagtt attattttcc catttgctgt ctttttgtat ctaaagtctt cctattgtac    840

tgcacaaacc atggattgta catattttta tatattatgt c                        881


